WO2023059053A1 - Composition pour prévenir ou soulager la perte de cheveux, comprenant un extrait de sétaire d'italie glutineux samda - Google Patents

Composition pour prévenir ou soulager la perte de cheveux, comprenant un extrait de sétaire d'italie glutineux samda Download PDF

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Publication number
WO2023059053A1
WO2023059053A1 PCT/KR2022/014966 KR2022014966W WO2023059053A1 WO 2023059053 A1 WO2023059053 A1 WO 2023059053A1 KR 2022014966 W KR2022014966 W KR 2022014966W WO 2023059053 A1 WO2023059053 A1 WO 2023059053A1
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WO
WIPO (PCT)
Prior art keywords
extract
samda
perilla
hair loss
dermal papilla
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PCT/KR2022/014966
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English (en)
Korean (ko)
Inventor
강희경
강정일
최윤경
오태헌
이혜자
염현숙
Original Assignee
제주대학교 산학협력단
대봉엘에스 주식회사
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Publication of WO2023059053A1 publication Critical patent/WO2023059053A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a composition for preventing or improving hair loss containing an extract of cedar algae. Specifically, the present invention relates to a cosmetic composition for preventing or improving hair loss by increasing the proliferation of dermal papilla cells, comprising a Samda perilla extract as an active ingredient.
  • Dermal papilla cells are key cells responsible for the development and growth of hair, and are located at the bottom of the hair root, which is the root of the hair subcutaneously. In fact, when dermal papilla cells are collected from the scalp, cultured, and transplanted, new hair grows. However, there are several difficulties in using dermal papilla cells as a hair loss treatment. First, it is difficult to separate from the scalp, the culture conditions are difficult, and it is difficult to culture a sufficient amount of cells. In addition, when cultured a lot, there is a limit in that the hair regeneration ability is significantly lowered.
  • Finasteride and dutasteride are 5 ⁇ -reductase inhibitors that inhibit the conversion of testosterone to 5 ⁇ -dihydrotestosterone (DHT).
  • DHT 5 ⁇ -dihydrotestosterone
  • Samdachajo is a native Jeju region, and is a kind of grain of millet ( Setaria italica ).
  • Korean Patent Registration No. 10-2150927 discloses the anti-inflammatory effect, skin moisturizing effect, skin barrier strengthening effect, and atopy improving effect of the mixed extract of Samda algae, the effect of improving hair loss of the Samda alga extract is not disclosed at all.
  • the inventors of the present invention completed the present invention by discovering that the Samda perilla extract has an effect of proliferating dermal papilla cells in the process of researching a substance having excellent preventive and therapeutic effects on hair loss with few side effects.
  • Patent Document 1 Korean Patent Registration No. 10-2150927
  • An object of the present invention is to provide a cosmetic composition for preventing or improving hair loss containing an extract of cedar algae.
  • the present invention provides a cosmetic composition for preventing or improving hair loss containing an extract of cedar algae.
  • the Samdachajo extract may be extracted with a solvent selected from the group consisting of water, C1 to C6 alcohol, ethyl acetate, hexane, chloroform, and mixed solvents thereof, but is not limited thereto.
  • the Samda perilla extract of the present invention may be a 0.01% to 90% ethanol extract or a butanol extract, more preferably, the Samda perilla extract of the present invention may be a 60% to 80% ethanol extract or a butanol extract, and most preferably The extract of Samdachajo of the present invention may be a 70% ethanol extract or a butanol extract.
  • the samda perilla extract of the present invention can prevent or improve hair loss by increasing the proliferation of dermal papilla cells.
  • composition containing the extract of Samdacha algae of the present invention as an active ingredient promotes the proliferation of dermal papilla cells to induce the growth phase of hair, while having few side effects, so it can be effectively used to improve hair growth or hair loss.
  • Figure 1 shows the results of measuring the proliferation effect of dermal papilla cells for 70% ethanol extract of Samda perilla.
  • Figure 2 shows the results of measuring the proliferation effect of dermal papilla cells for the hexane extract of Samdachajo.
  • Figure 3 shows the results of measuring the proliferation effect of dermal papilla cells for the ethyl acetate extract of Samda perilla.
  • Figure 4 shows the results of measuring the proliferation effect of dermal papilla cells for the chloroform extract of Samda perilla.
  • Figure 5 shows the results of measuring the proliferation effect of dermal papilla cells for the butanol extract of Samda perilla.
  • Figure 6 shows the results of measuring the proliferation effect of dermal papilla cells on the hot water extract of Samdachajo.
  • Figure 7 shows the results of measuring the proliferation effect of dermal papilla cells for the perilla 70% ethanol extract.
  • Figure 8 shows the results of measuring the proliferation effect of dermal papilla cells on the perilla hot water extract.
  • the present invention relates to a cosmetic composition for preventing or improving hair loss containing an extract of samda perilla.
  • Air loss refers to a condition in which there is no hair in an area where hair should normally exist, regardless of the cause, and includes circular alopecia, hereditary androgenetic alopecia, telogen effluvium, traumatic alopecia, hair growth, pressure alopecia, It may be anagen hair loss, pityroid hair loss, syphilitic hair loss, seborrheic hair loss, symptomatic hair loss, scarring hair loss or congenital hair loss, but is not limited thereto.
  • Samdachal ( Setaria italica Beauv.) of the present invention is a kind of millet, which is a grain, and is a native perilla native to the Jeju region, and the breed name is Samdachal (see National Seed Resources).
  • Samda tea which is harvested from Jeju Island, but is not limited thereto.
  • the ginseng extract of the present invention promotes the proliferation of dermal papilla cells and induces the growth phase of hair, thereby exhibiting an effect of preventing or improving hair loss.
  • Prevention of the present invention refers to any action that suppresses or delays the onset of hair loss by administration of the composition according to the present invention, and “improvement” is related to the condition treated by administration of the composition containing the extract of the present invention. Any action that at least reduces the severity of a parameter, eg a symptom.
  • the "extract" of the present invention can be obtained using a conventional extraction solvent known in the art.
  • a polar solvent or a non-polar solvent may be used as the extraction solvent.
  • Polar solvents include water, C1 to C6 alcohols (eg, methanol, ethanol, propanol, butanol, n-propanol, iso-propanol and n-butanol, etc.), acetic acid, or mixtures of the above polar solvents.
  • Non-polar solvents include acetone, acetonitrile, ethyl acetate, methyl acetate, butyl acetate, fluoroalkanes, hexane, ether, chloroform, dichloromethane or mixtures of the above non-polar solvents.
  • the extract may be extracted with a solvent selected from the group consisting of water, C1 to C6 alcohol, acetic acid, and a mixed solvent thereof.
  • a solvent selected from the group consisting of water, C1 to C6 alcohol, acetic acid, and a mixed solvent thereof.
  • it is 0.01% to 90% ethanol extract or butanol extract, more preferably 60% to 80% ethanol extract or butanol extract, and most preferably 70% ethanol extract or butanol extract.
  • the extract of the present invention may be extracted through hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, or a conventional extraction method known in the art.
  • extract used in the present invention means what is commonly used as a crude extract in the art, but also includes a fraction obtained by additional fractionation of the extract in a broad sense. That is, the extract includes not only those obtained using the above-described solvent, but also those obtained by additionally applying a purification process thereto. For example, a fraction obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatographs (designed for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through the purification method are also included in the crude drug extract of the present invention.
  • the cosmetic composition of the present invention is a solution, gel, solid or kneaded anhydrous product, emulsion obtained by dispersing an oil phase in an aqueous phase, suspension, microemulsion, microcapsule, microgranule or ionic (liposome), nonionic vesicle dispersant.
  • emulsion obtained by dispersing an oil phase in an aqueous phase, suspension, microemulsion, microcapsule, microgranule or ionic (liposome), nonionic vesicle dispersant.
  • it can be prepared in the form of a foam (foam) or the form of an aerosol composition further containing a compressed propellant.
  • the cosmetic composition may include a fatty substance, an organic solvent, a solubilizing agent, a thickening agent and a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, ionic or nonionic Cosmetics such as emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blocking agents, humectants, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredient commonly used in cosmetics It may contain adjuvants commonly used in the field.
  • the cosmetic composition of the present invention may be, for example, a hair cosmetic.
  • the cosmetic composition for hair may be prepared in any one formulation selected from the group consisting of hair shampoo, hair lotion, hair conditioner, hair treatment, hair tonic, hair essence, hair serum, scalp treatment, and hair nutrient lotion. It is not particularly limited in making it.
  • other ingredients in addition to the above essential ingredients in each formulation may be appropriately selected depending on the type of external preparation or purpose of use.
  • Samda-chajo 70% ethanol extract Samda-chajo hot water extract, Samda-chajo hexane extract, Samda-chajo ethyl acetate extract, Samda-chajo chloroform extract, Samda-chajo butanol extract, Samda-chajo 70% ethanol extract, and Samda-chajo hot-water extract were prepared.
  • Proliferation of rat vibrissa immortalized dermal papilla cells immortalized from dermal papilla cells isolated from rat whiskers was measured using the MTT assay.
  • Dermal papilla cells (1.0 ⁇ 10 4 cells/mL) were turbid in DMEM medium containing 1% FBS, placed in a 96 well plate, and cultured for 24 hours.
  • Samdachajo 70% ethanol extract was treated at concentrations of 1, 10 and 25 ⁇ g/mL.
  • minoxidil Sigma, MO, USA
  • 10 ⁇ M concentration 10 ⁇ M concentration.
  • WST dye Daeil Lab Service, Seoul, Korea
  • Absorbance was measured at 450 nm using a VERSAmax microplate reader (Molecular Devices, CA, USA). The average absorbance value for the sample group was obtained, and the degree of proliferation was investigated in comparison with the absorbance value of the control group, and is shown in Table 1 and FIG. 1 below.
  • the 70% ethanol extract of Samdachajo has a dermal papilla cell proliferation effect.
  • the hexane extract of Samdachajo has the dermal papilla cell proliferation effect.
  • the ethyl acetate extract of Samdachajo has an effect on dermal papilla cell proliferation.
  • the chloroform extract of Samda perilla has the dermal papilla cell proliferation effect.
  • the butanol extract of Samdachajo has the dermal papilla cell proliferation effect.
  • Example 3 In the same manner as in Example 3, an experiment was performed on the dermal papilla cell proliferation effect of the hot water extract of Samdacha algae, and the results are shown in Table 6 and FIG. 6 below.
  • control group 100.0 minoxidil (positive control) 10 ⁇ M 109.1
  • Perilla hot water extract 1 ⁇ g/mL 99.4 ⁇ 3.5
  • Perilla hot water extract 10 ⁇ g/mL 101.4 ⁇ 4.4
  • Perilla hot water extract 25 ⁇ g/mL 101.3 ⁇ 5.5

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention se rapporte à une composition pour prévenir ou soulager la perte de cheveux, la composition comprenant un extrait de sétaire d'Italie glutineux Samda. Plus particulièrement, la présente invention se rapporte à une composition cosmétique pour prévenir ou soulager la perte de cheveux par augmentation de la prolifération de cellules de papille dermique, la composition comprenant un extrait de sétaire d'Italie glutineux Samda en tant que principe actif.
PCT/KR2022/014966 2021-10-08 2022-10-05 Composition pour prévenir ou soulager la perte de cheveux, comprenant un extrait de sétaire d'italie glutineux samda WO2023059053A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2021-0134094 2021-10-08
KR1020210134094A KR102622831B1 (ko) 2021-10-08 2021-10-08 삼다차조 추출물을 포함하는 탈모의 예방 또는 개선을 위한 조성물

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WO2023059053A1 true WO2023059053A1 (fr) 2023-04-13

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520588A (ja) * 2004-11-18 2008-06-19 ビオファーマコペ デジン アンテルナショナル インク． 植物抽出物およびその皮膚科使用法
KR20190037777A (ko) * 2017-09-29 2019-04-08 유씨엘 주식회사 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물
KR20200091361A (ko) * 2019-01-22 2020-07-30 이동완 오이, 가지 및 달팽이의 혼합 추출물을 유효성분으로 포함하는 탈모 방지 또는 발모 촉진용 조성물
KR20210012169A (ko) * 2019-07-24 2021-02-03 주식회사 바이오원코리아 식물 생약재를 포함하는 탈모 예방 및 발모용 식품 조성물 및 그 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3830960B1 (ja) * 2005-08-12 2006-10-11 建仁 河乃 育毛物質
KR102150927B1 (ko) * 2018-12-31 2020-09-02 대봉엘에스 주식회사 조릿대 추출물 및 우레아를 포함하는 화장료 및 약학적 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520588A (ja) * 2004-11-18 2008-06-19 ビオファーマコペ デジン アンテルナショナル インク． 植物抽出物およびその皮膚科使用法
KR20190037777A (ko) * 2017-09-29 2019-04-08 유씨엘 주식회사 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물
KR20200091361A (ko) * 2019-01-22 2020-07-30 이동완 오이, 가지 및 달팽이의 혼합 추출물을 유효성분으로 포함하는 탈모 방지 또는 발모 촉진용 조성물
KR20210012169A (ko) * 2019-07-24 2021-02-03 주식회사 바이오원코리아 식물 생약재를 포함하는 탈모 예방 및 발모용 식품 조성물 및 그 제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LAONWHOJE: "Laon's Grains - Glutinous Millet's Types and Benefits", NAVER BLOG, KR, KR, pages 1 - 2, XP009546265, Retrieved from the Internet <URL:https://blog.naver.com/laonwhoje/222291307403> [retrieved on 20230809] *

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KR20230050829A (ko) 2023-04-17

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