WO2023059047A1 - Composition pour la prévention ou le traitement de la chute des cheveux, comprenant un extrait de samdachal-jo (millet glutineux de jeju) - Google Patents

Composition pour la prévention ou le traitement de la chute des cheveux, comprenant un extrait de samdachal-jo (millet glutineux de jeju) Download PDF

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Publication number
WO2023059047A1
WO2023059047A1 PCT/KR2022/014951 KR2022014951W WO2023059047A1 WO 2023059047 A1 WO2023059047 A1 WO 2023059047A1 KR 2022014951 W KR2022014951 W KR 2022014951W WO 2023059047 A1 WO2023059047 A1 WO 2023059047A1
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WO
WIPO (PCT)
Prior art keywords
extract
hair loss
perilla
samda
dermal papilla
Prior art date
Application number
PCT/KR2022/014951
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English (en)
Korean (ko)
Inventor
강희경
강정일
최윤경
Original Assignee
제주대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from KR1020210134050A external-priority patent/KR102684917B1/ko
Application filed by 제주대학교 산학협력단 filed Critical 제주대학교 산학협력단
Publication of WO2023059047A1 publication Critical patent/WO2023059047A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat

Definitions

  • the present invention relates to a composition for preventing, treating, or improving hair loss comprising an extract of cedar algae.
  • the present invention relates to a pharmaceutical composition or a food composition for preventing, treating, or improving hair loss by increasing the proliferation of dermal papilla cells, comprising an extract of Samdacha algae as an active ingredient.
  • Dermal papilla cells are key cells responsible for the development and growth of hair, and are located at the bottom of the hair root, which is the root of the hair subcutaneously. In fact, when dermal papilla cells are collected from the scalp, cultured, and transplanted, new hair grows. However, there are several difficulties in using dermal papilla cells as a hair loss treatment. First, it is difficult to separate from the scalp, the culture conditions are difficult, and it is difficult to culture a sufficient amount of cells. In addition, when cultured a lot, there is a limit in that the hair regeneration ability is significantly lowered.
  • Finasteride and dutasteride are 5 ⁇ -reductase inhibitors that inhibit the conversion of testosterone to 5 ⁇ -dihydrotestosterone (DHT).
  • DHT 5 ⁇ -dihydrotestosterone
  • Samdachajo is a native Jeju region, and is a kind of grain of millet ( Setaria italica ).
  • Korean Patent Registration No. 10-2150927 discloses the anti-inflammatory effect, skin moisturizing effect, skin barrier strengthening effect, and atopy improving effect of the mixed extract of Samda algae, the effect of improving hair loss of the Samda alga extract is not disclosed at all.
  • the inventors of the present invention completed the present invention by discovering that the Samda perilla extract has an effect of proliferating dermal papilla cells in the process of researching a substance having excellent preventive and therapeutic effects on hair loss with few side effects.
  • Patent Document 1 Korean Patent Registration No. 10-2150927
  • An object of the present invention is to provide a pharmaceutical composition for the prevention or treatment of hair loss containing an extract of cedar algae.
  • an object of the present invention is to provide a food composition for the prevention or improvement of hair loss containing the extract of cedar algae.
  • the present invention provides a pharmaceutical composition for the prevention or treatment of hair loss containing the extract of cedar algae.
  • the present invention provides a food composition for the prevention or improvement of hair loss containing the extract of Samdachajo.
  • the Samdachajo extract may be extracted with a solvent selected from the group consisting of water, C1 to C6 alcohol, ethyl acetate, hexane, chloroform, and mixed solvents thereof, but is not limited thereto.
  • the Samda perilla extract of the present invention may be 0.01% to 90% ethanol extract or butanol extract, more preferably, the Samda perilla extract of the present invention may be 60% to 80% ethanol extract or butanol extract, and most preferably Preferably, the extract of Samdachajo of the present invention may be a 70% ethanol extract or a butanol extract.
  • the extract of Samdachajo of the present invention can prevent, treat, or improve hair loss by increasing the proliferation of dermal papilla cells.
  • composition containing the extract of Samdacha algae of the present invention as an active ingredient promotes the proliferation of dermal papilla cells to induce the growth phase of hair, while having few side effects, so it can be effectively used to improve hair growth or hair loss.
  • Figure 1 shows the results of measuring the proliferation effect of dermal papilla cells for 70% ethanol extract of Samda perilla.
  • Figure 2 shows the results of measuring the proliferation effect of dermal papilla cells for the hexane extract of Samdachajo.
  • Figure 3 shows the results of measuring the proliferation effect of dermal papilla cells for the ethyl acetate extract of Samda perilla.
  • Figure 4 shows the results of measuring the proliferation effect of dermal papilla cells for the chloroform extract of Samda perilla.
  • Figure 5 shows the results of measuring the proliferation effect of dermal papilla cells for the butanol extract of Samda perilla.
  • Figure 6 shows the results of measuring the proliferation effect of dermal papilla cells on the hot water extract of Samdachajo.
  • Figure 7 shows the results of measuring the proliferation effect of dermal papilla cells for the perilla 70% ethanol extract.
  • Figure 8 shows the results of measuring the proliferation effect of dermal papilla cells on the perilla hot water extract.
  • the present invention relates to a pharmaceutical composition for the prevention or treatment of hair loss comprising an extract of cedar algae.
  • Air loss refers to a condition in which there is no hair in an area where hair should normally exist, regardless of the cause, and includes circular alopecia, hereditary androgenetic alopecia, telogen effluvium, traumatic alopecia, hair growth, pressure alopecia, It may be anagen hair loss, pityroid hair loss, syphilitic hair loss, seborrheic hair loss, symptomatic hair loss, scarring hair loss or congenital hair loss, but is not limited thereto.
  • Samda chajo Setaria italica Beauv.
  • Samda tea which is harvested from Jeju Island, but is not limited thereto.
  • the ginseng extract of the present invention can exhibit the effect of preventing or treating hair loss by promoting the proliferation of dermal papilla cells and inducing the growth phase of hair.
  • Treatment of the present invention is to improve the symptoms of hair loss by delaying or stopping the progress of hair loss by administering the composition of the present invention, or beneficially changing the symptoms of hair loss, such as promoting hair growth and hair growth, such as lengthening or increasing the number of hairs. means all actions
  • Prevention of the present invention refers to any action that suppresses or delays the onset of hair loss by administration of the composition according to the present invention, and “improvement” is related to the condition treated by administration of the composition containing the extract of the present invention. Any action that at least reduces the severity of a parameter, eg a symptom.
  • the "extract" of the present invention can be obtained using a conventional extraction solvent known in the art.
  • a polar solvent or a non-polar solvent may be used as the extraction solvent.
  • Polar solvents include water, C1 to C6 alcohols (eg, methanol, ethanol, propanol, butanol, n-propanol, iso-propanol and n-butanol, etc.), acetic acid, or mixtures of the above polar solvents.
  • Non-polar solvents include acetone, acetonitrile, ethyl acetate, methyl acetate, butyl acetate, fluoroalkanes, hexane, ether, chloroform, dichloromethane or mixtures of the above non-polar solvents.
  • the extract may be extracted with a solvent selected from the group consisting of water, C1 to C6 alcohol, acetic acid, and a mixed solvent thereof.
  • a solvent selected from the group consisting of water, C1 to C6 alcohol, acetic acid, and a mixed solvent thereof.
  • it is 0.01% to 90% ethanol extract or butanol extract, more preferably 60% to 80% ethanol extract or butanol extract, and most preferably 70% ethanol extract or butanol extract.
  • the extract of the present invention may be extracted through hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, or a conventional extraction method known in the art.
  • extract used in the present invention means what is commonly used as a crude extract in the art, but also includes a fraction obtained by additional fractionation of the extract in a broad sense. That is, the extract includes not only those obtained using the above-described solvent, but also those obtained by additionally applying a purification process thereto. For example, a fraction obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatographs (designed for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through the purification method are also included in the crude drug extract of the present invention.
  • the pharmaceutical composition of the present invention can be parenterally administered or orally administered according to the desired method, and the dosage depends on the patient's weight, age, sex, health condition, diet, administration time, administration method, excretion rate, and severity of the disease. Its range is diverse.
  • the therapeutically effective amount of the composition may vary depending on the administration method, the target site, and the condition of the patient, and when used in the human body, the dosage should be determined in an appropriate amount in consideration of safety and efficiency.
  • the present invention relates to a food composition for preventing or improving hair loss comprising a samdachajo composition.
  • the food composition may be a health functional food, dairy product, fermented product or food additive.
  • the “health functional food” refers to food manufactured and processed using raw materials or ingredients having useful functionalities for the human body, and “functional” refers to health uses such as adjusting nutrients for the structure and function of the human body or physiological actions, etc. It means to take it for the purpose of obtaining a beneficial effect on it.
  • the food composition is various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants and enhancers (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and It may further include salts thereof, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohol, carbonation agents used in carbonated beverages, and the like.
  • the food composition includes a form such as a pill, powder, granule, precipitate, tablet, capsule, liquid, paste, gel, or jelly, and the food to which the composition can be added includes, for example, There are various types of foods, such as beverages, chewing gum, tea, vitamin complexes, health supplements, and the like.
  • the formulation of the food composition is not particularly limited, but may be formulated into, for example, tablets, granules, powders, liquids such as drinks, caramels, gels, bars, and the like.
  • the food composition of each formulation can be formulated without difficulty by a person skilled in the art according to the formulation or purpose of use by selecting and blending ingredients commonly used in the field in addition to the active ingredient.
  • Samda-chajo 70% ethanol extract Samda-chajo hot water extract, Samda-chajo hexane extract, Samda-chajo ethyl acetate extract, Samda-chajo chloroform extract, Samda-chajo butanol extract, Samda-chajo 70% ethanol extract, and Samda-chajo hot-water extract were prepared.
  • Proliferation of rat vibrissa immortalized dermal papilla cells immortalized from dermal papilla cells isolated from rat whiskers was measured using the MTT assay.
  • Dermal papilla cells (1.0 ⁇ 10 4 cells/mL) were turbid in DMEM medium containing 1% FBS, placed in a 96 well plate, and cultured for 24 hours.
  • Samdachajo 70% ethanol extract was treated at concentrations of 1, 10 and 25 ⁇ g/mL.
  • minoxidil Sigma, MO, USA
  • 10 ⁇ M concentration 10 ⁇ M concentration.
  • WST dye Daeil Lab Service, Seoul, Korea
  • Absorbance was measured at 450 nm using a VERSAmax microplate reader (Molecular Devices, CA, USA). The average absorbance value for the sample group was obtained, and the degree of proliferation was investigated in comparison with the absorbance value of the control group, and is shown in Table 1 and FIG. 1 below.
  • the 70% ethanol extract of Samdachajo has a dermal papilla cell proliferation effect.
  • control group - 100.0 minoxidil (positive control) 10 ⁇ M 109.1 Samda tea hexane extract 1 ⁇ g/mL 100.3 ⁇ 6.1
  • the hexane extract of Samdachajo has the dermal papilla cell proliferation effect.
  • Example 3 In the same manner as in Example 3, an experiment was performed on the dermal papilla cell proliferation effect of the extract of Samda perilla ethyl acetate, and the results are shown in Table 3 and FIG. 3 below.
  • the ethyl acetate extract of Samdachajo has a dermal papilla cell proliferation effect.
  • the chloroform extract of Samda perilla has the dermal papilla cell proliferation effect.
  • the butanol extract of Samdachajo has the dermal papilla cell proliferation effect.
  • Example 3 In the same manner as in Example 3, an experiment was performed on the dermal papilla cell proliferation effect of the hot water extract of Samdacha algae, and the results are shown in Table 6 and FIG. 6 below.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une composition pour prévenir, traiter ou atténuer une perte de cheveux, comprenant un extrait de Samdachal-jo (millet glutineux de Jeju). En particulier, la présente invention concerne une composition pharmaceutique ou une composition alimentaire pour prévenir, traiter ou atténuer la perte de cheveux par l'augmentation de la prolifération de cellules de papille dermique, la composition comprenant un extrait de Samdachal-jo en tant que principe actif.
PCT/KR2022/014951 2021-10-08 2022-10-05 Composition pour la prévention ou le traitement de la chute des cheveux, comprenant un extrait de samdachal-jo (millet glutineux de jeju) WO2023059047A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2021-0134050 2021-10-08
KR1020210134050A KR102684917B1 (ko) 2021-10-08 삼다차조 추출물을 포함하는 탈모의 예방 또는 치료를 위한 조성물

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WO2023059047A1 true WO2023059047A1 (fr) 2023-04-13

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520588A (ja) * 2004-11-18 2008-06-19 ビオファーマコペ デジン アンテルナショナル インク． 植物抽出物およびその皮膚科使用法
KR20190037777A (ko) * 2017-09-29 2019-04-08 유씨엘 주식회사 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물
KR20200091361A (ko) * 2019-01-22 2020-07-30 이동완 오이, 가지 및 달팽이의 혼합 추출물을 유효성분으로 포함하는 탈모 방지 또는 발모 촉진용 조성물
KR20210012169A (ko) * 2019-07-24 2021-02-03 주식회사 바이오원코리아 식물 생약재를 포함하는 탈모 예방 및 발모용 식품 조성물 및 그 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520588A (ja) * 2004-11-18 2008-06-19 ビオファーマコペ デジン アンテルナショナル インク． 植物抽出物およびその皮膚科使用法
KR20190037777A (ko) * 2017-09-29 2019-04-08 유씨엘 주식회사 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물
KR20200091361A (ko) * 2019-01-22 2020-07-30 이동완 오이, 가지 및 달팽이의 혼합 추출물을 유효성분으로 포함하는 탈모 방지 또는 발모 촉진용 조성물
KR20210012169A (ko) * 2019-07-24 2021-02-03 주식회사 바이오원코리아 식물 생약재를 포함하는 탈모 예방 및 발모용 식품 조성물 및 그 제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAON: "The Grains of Raon - Types and Effects of Setaria italica Beauv. 라온의 곡류 – 차조의 종류 및 효능", NAVER BLOG, 29 March 2021 (2021-03-29), Retrieved from the Internet <URL:https://blog.naver.com/laonwhoje/222291307403> *

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