WO2017005090A1 - 微纳米级医用吸附树脂粉料 - Google Patents

微纳米级医用吸附树脂粉料 Download PDF

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WO2017005090A1
WO2017005090A1 PCT/CN2016/086677 CN2016086677W WO2017005090A1 WO 2017005090 A1 WO2017005090 A1 WO 2017005090A1 CN 2016086677 W CN2016086677 W CN 2016086677W WO 2017005090 A1 WO2017005090 A1 WO 2017005090A1
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micro
nano
resin powder
adsorption resin
powder according
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PCT/CN2016/086677
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English (en)
French (fr)
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于杰
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于杰
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Priority claimed from CN201510399777.4A external-priority patent/CN106334242A/zh
Priority claimed from CN201510441375.6A external-priority patent/CN106362158A/zh
Priority claimed from CN201510510311.7A external-priority patent/CN106467984A/zh
Priority claimed from CN201610028904.4A external-priority patent/CN106974819A/zh
Priority claimed from CN201610047350.2A external-priority patent/CN106994336A/zh
Application filed by 于杰 filed Critical 于杰
Priority to EP16820741.3A priority Critical patent/EP3321296A4/en
Priority to JP2018520008A priority patent/JP2018522943A/ja
Priority to US15/736,792 priority patent/US20180185492A1/en
Publication of WO2017005090A1 publication Critical patent/WO2017005090A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0225—Compounds of Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt
    • B01J20/0229—Compounds of Fe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
    • C08F212/02—Monomers containing only one unsaturated aliphatic radical
    • C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
    • C08F212/06—Hydrocarbons
    • C08F212/08—Styrene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
    • C08F212/34—Monomers containing two or more unsaturated aliphatic radicals
    • C08F212/36—Divinylbenzene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F218/02—Esters of monocarboxylic acids
    • C08F218/04—Vinyl esters
    • C08F218/08—Vinyl acetate

Definitions

  • the material form of the macroporous adsorption resin is a conventional granular form, which is used as an adsorbent for filling a blood perfusion device in blood purification therapy, and the particle size is applicable to a range of 80 mesh (178 um).
  • the particle size is applicable to a range of 80 mesh (178 um).
  • the object of the present invention is to propose a technical solution of a micro-nano-sized particle size medical adsorption resin material, and a technical solution for the use of the material.
  • the content of the invention is: a micro-nano-grade medical adsorption resin powder characterized by being a high-molecular polymer composed of carbon, hydrogen and oxygen element ions; the molecular structure comprises a benzene ring and a hydroxyl group, and the polymer comprises at least two One or more molecules; the overall particle size is in the range of 0.01-50 um, preferably in the range of 0.01-1.5 um (10-1500 nm).
  • the high molecular polymer is vinyl acetate and a divinylbenzene polymer.
  • Embodiment 2 The high molecular polymer is styrene and divinylbenzene polymer.
  • Embodiment 3 Linking a sugar molecular chain to a bond of a polymer carbon skeleton and/or a branch to form a glycosylated polymer.
  • Embodiment 4 embedding a transition element metal ion on a polymer carbon skeleton; the metal element is an iron element.
  • micro-nano medical adsorption resin powder of the present invention examples include:
  • Embodiment 5 The powder is directly used as a coating agent for skin or body tissues or living organs or surfaces of living organs.
  • Example 6 The powder is used as a carrier or a life-interesting substance, including a carrier for stem cells.
  • Embodiment 7 The powder is used as a medical molding material, including: a hollow fiber, or a silica gel transfusion, an infusion tube, or a dialysis membrane, or a filler for a medical coating, or an excipient that is integrated with the surface thereof.
  • a medical molding material including: a hollow fiber, or a silica gel transfusion, an infusion tube, or a dialysis membrane, or a filler for a medical coating, or an excipient that is integrated with the surface thereof.
  • Example 8 The powder is used as a solute, and is prepared as a solution by injection or physiological saline or ethanol solution of different purity, including fruit wine.
  • a powder is added to a forming material to form a paste, or a pill, or a grease.
  • the powder of the present invention is added to the molding material, or the shaping material, or the highest proportion of the solution is limited to the powder which can be added at most, and there is no certain limit to the minimum ratio.
  • the amount of powder added determines the extent of the effect without affecting the molding material, or the shaping material, or the conditions under which the solution is used.
  • micro-nano effect and quantum effect of the material of the invention are as follows: in the micro-nano-material interface micro-environment, the adsorption resin micro-nano particles can penetrate the skin, muscle tissue and cell membrane, and are actively and affinity-driven under the equilibrium potential. The adsorption of the adsorbent causes the adsorbed substances, including the active cells, the intracellular genetic material DNA ⁇ RNA, and the apoptotic macromolecules to be resolved and collapsed, and the fragments are affinity-adsorbed into the metabolic system and excreted.
  • the animal model test proves that the micro-nano resin powder is coated on the outer wall of the blood vessel, so that the fatty substances accumulated on the inner wall of the blood vessel can be analyzed as a "smoke" and flow with the blood; the cancerous tissue instantaneously collapses into a "smoke” Take away the blood.
  • Volunteers are liver cancer patients who have reached the state of clinical liver necrosis (received a death notice). The liver was exposed by surgery, and the micro-nano resin powder was directly applied to the outside of the liver, that is, it quickly infiltrated into the liver tissue, and the liver tissue began to restore blood color; cancerous tissue tissue fragments were observed in the blood drawn from the hepatic vein.
  • the polymer molecule of the medical adsorption resin powder of the invention is a chemical synthetic product, has chemical stability, does not participate in biochemical reaction, and has no side effects in clinical use.
  • Various use examples of the present invention are different use forms of the resin powder of the present invention, which are respectively suitable for skin coating, oral administration, injection dosage form and the like.
  • the outstanding substantive features of the present invention are the micro-nano effect and quantum effect of the medical adsorption resin.
  • a significant advancement of the present invention is the development of new fields of application for medical adsorption resins.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

微纳米级医用吸附树脂粉料，其特征在于：是由碳、氢、氧元素离子组成的高分子聚合物。

Description

微纳米级医用吸附树脂粉料
所属技术领域：医用材料
背景技术：在此前医用大孔吸附树脂的材料形态都是常规的颗粒状，其在血液净化疗法中用做血液灌流器内充填的吸附剂，粒径适用范围为80目(178um)。没有微纳米级粒径医用树脂的文献报道。
发明内容：
本发明的目的是提出微纳米级粒径医用吸附树脂材料技术方案，以及该种材料的用途技术方案。
本发明的内容是：微纳米级医用吸附树脂粉料，其特征在于：是由碳、氢、氧元素离子组成的高分子聚合物；分子结构中包含有苯环和羟基，聚合物包含至少两个或以上的分子；其整体粒径在在0.01-50um范围内，以0.01-1.5um(10-1500nm)范围为佳。
本发明的实施例：
实施例之一：所述的高分子聚合物是醋酸乙烯酯与二乙烯苯聚合物。
实施例之二：所述的高分子聚合物是苯乙烯与二乙烯苯聚合物。
实施例之三：在聚合物碳骨架和/或支链的键位上链接糖分子链，成为糖基化聚合物。
实施例之四：在聚合物碳骨架上嵌入过渡元素金属离子；所述的金属元素是铁元素。
本发明微纳米级医用吸附树脂粉料的用途的实施例：
实施例之五：将粉料直接作为皮肤或者机体组织或者活体脏器或者活体器官表面的涂覆剂。
实施例之六：将粉料作为携带药物或者生命干预物质，包括干细胞的载体。
实施例之七：将粉料作为医用成型材料，包括：中空纤维，或者硅胶输血、输液管，或者透析膜，或者医用覆膜的填充剂，或者与其表面结为一体的赋型剂。
实施例之八：将粉料作为溶质，以注射液或者生理盐水或者不同纯度的乙醇溶液、包括果酒为溶剂配制成溶液。
实施例之九：将粉料加入赋型材料中制成膏剂，或者丸剂，或者油脂剂。
在上述用途实施例七到九中，本发明粉料加入成型材料，或者赋型材料，或者溶液中最高比例以最多可以加入的粉料为限，对最低比例没有确定的限制。在不影响成型材料，或者赋型材料，或者溶液使用的条件下，加入粉料的量决定其作用大小。
本发明材料的微纳米效应和量子效应表现在：在微纳米级物质界面微环境下，吸附树脂微微纳米颗粒可以穿透皮肤、肌肉组织和细胞膜，在平衡势驱动下主动与具有亲和性的吸附质碰撞，使吸附质物质，包括：活性细胞、胞内遗传物质DNA\RNA、和凋亡的生命物质大分子发生解析、崩溃，碎片被亲和性吸附进入代谢系统排出体外。动物模型试验证明，血管壁外涂覆微纳米树脂粉料，可以使血管内壁上堆积的脂肪类物质解析“一股烟”似的随血液流去；癌变组织瞬时崩溃成“一股烟”被血液带走。志愿者是已经到临床肝坏死状态(接到死亡通知书)的肝癌患者。手术将肝脏裸露，使用微纳米树脂粉料直接涂覆在肝脏外部，即很快渗入肝组织，肝组织随即开始恢复血色；在肝静脉处引出的血液中观察到癌变细胞组织碎片分子。待肝脏恢复血色，引出的血液颜色恢复正常时缝合腹腔，手术全程四个小时。术后三天志愿者饮食恢复正常，一周后出院。在此例约一年之前，曾经有过肝移植手术，因供体坏死而在不得已情况下，将患者已经切除的坏肝放入微纳米树脂粉料的生理盐水溶液中浸泡，坏死组织使溶液变成黑色，同时离体的肝恢复血色被再次接入体内。患者术后没有不良反应，很快出院。此外，笔者与同事做志愿者多次试用。效果是：口服可以调血糖，皮肤涂覆可以美白，可以消除皮下积液，可以快速愈合伤口等等。
本发明医用吸附树脂粉料的聚合物分子是化工合成产品，具有化学稳定性，不参加生物化学反应，临床使用没有副作用。
本发明的各种用途实施例是本发明树脂粉料的不同使用形式，分别适用于皮肤涂覆、口服、注射剂型等等。
本发明具有突出的实质性特点是体现了医用吸附树脂的微纳米效应和量子效应。
本发明的显著进步在于开辟了医用吸附树脂新的应用领域。

Claims (11)

  1. 微纳米级医用吸附树脂粉料，其特征在于：是由碳、氢、氧元素离子组成的高分子聚合物；分子结构中包含有苯环和羟基，聚合物包含至少两个或以上的分子；其整体粒径在0.01-50微米(um)范围内，以0.01-1.5微米(10-1500nm)范围为佳。
  2. 如权利要求1所述的微纳米级医用吸附树脂粉料，其特征在于：所述的高分子聚合物是醋酸乙烯酯与二乙烯苯聚合物。
  3. 如权利要求1所述的微纳米级医用吸附树脂粉料，其特征在于：所述的高分子聚合物是苯乙烯与二乙烯苯聚合物。
  4. 如权利要求2或3所述的微纳米级医用吸附树脂粉料，其特征在于：在其碳骨架和/或支链的键位上链接糖分子链，成为糖基化聚合物。
  5. 如权利要求2或3所述的微纳米级医用吸附树脂粉料，其特征在于：在其碳骨架上嵌入过渡元素金属离子。
  6. 如权利要求2或3所述的微纳米级医用吸附树脂粉料，其特征在于：在其碳骨架上嵌入过渡元素金属离子；所述的金属元素是铁元素。
  7. 如权利要求1或2或3或4或5或6中的任一项所述的微纳米级医用吸附树脂粉料的用途，其特征在于：将粉料作为皮肤或者机体组织或者活体脏器或者活体器官表面的涂覆剂。
  8. 如权利要求1或2或3或4或5或6中的任一项所述的微纳米级医用吸附树脂粉料的用途，其特征在于：将粉料作为携带药物或者生命干预物质，包括干细胞的载体。
  9. 如权利要求1或2或3或4或5或6中的任一项所述的微纳米级医用吸附树脂粉料的用途，其特征在于：将粉料作为医用成型材料，包括：中空纤维，或者硅胶输血、输液管，或者透析膜，或者医用覆膜的填充剂，或者与其表面结为一体的赋型剂。
  10. 如权利要求1或2或3或4或5或6中的任一项所述的微纳米级医用吸附树脂粉料的用途，其特征在于：将粉料作为溶质，以注射液或者生理盐水或者不同纯度的乙醇溶液、包括果酒为溶剂配制成溶液。
  11. 如权利要求1或2或3或4或5或6中的任一项所述的微纳米级医用吸附树脂粉料的用途，其特征在于：将粉料加入赋型材料中制成膏剂，或者丸剂，或者油脂剂。
PCT/CN2016/086677 2015-07-09 2016-06-22 微纳米级医用吸附树脂粉料 WO2017005090A1 (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP16820741.3A EP3321296A4 (en) 2015-07-09 2016-06-22 Micro-nano medical adsorbent resin powder material
JP2018520008A JP2018522943A (ja) 2015-07-09 2016-06-22 マイクロナノ医療用吸着樹脂粉末
US15/736,792 US20180185492A1 (en) 2015-07-09 2016-06-22 Micro-nano medical adsorbent resin powder material

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
CN201510399777.4 2015-07-09
CN201510399777.4A CN106334242A (zh) 2015-07-09 2015-07-09 医用雾化器
CN201510441375.6 2015-07-25
CN201510441375.6A CN106362158A (zh) 2015-07-25 2015-07-25 增效药物
CN201510510311.7A CN106467984A (zh) 2015-08-19 2015-08-19 制做防护装具的化学纤维
CN201510510251.9 2015-08-19
CN201510510311.7 2015-08-19
CN201510510251 2015-08-19
CN201610028904.4A CN106974819A (zh) 2016-01-16 2016-01-16 微纳米级粒径的浴粉粉浴器
CN201610028904.4 2016-01-16
CN201610047350.2 2016-01-25
CN201610047350.2A CN106994336A (zh) 2016-01-25 2016-01-25 适用于精准血液净化疗法的医用吸附树脂
CN201610109578.X 2016-02-27
CN201610109578 2016-02-27

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Citations (11)

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