WO2016152279A1 - 粒子線照射システム - Google Patents

粒子線照射システム Download PDF

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Publication number
WO2016152279A1
WO2016152279A1 PCT/JP2016/053601 JP2016053601W WO2016152279A1 WO 2016152279 A1 WO2016152279 A1 WO 2016152279A1 JP 2016053601 W JP2016053601 W JP 2016053601W WO 2016152279 A1 WO2016152279 A1 WO 2016152279A1
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WIPO (PCT)
Prior art keywords
excitation current
irradiation
steering
control device
trajectory
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PCT/JP2016/053601
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English (en)
French (fr)
Japanese (ja)
Inventor
聡 遠竹
真澄 梅澤
広明 櫻畠
知久 今川
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株式会社日立製作所
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Publication of WO2016152279A1 publication Critical patent/WO2016152279A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present invention relates to a particle beam irradiation system, and more particularly to a particle beam irradiation system suitable for application to cancer treatment.
  • the particle beam irradiation system is roughly classified into a particle beam irradiation system having a synchrotron as an accelerator (for example, see Japanese Patent Application Laid-Open No. 2004-358237) and a particle beam irradiation system having a cyclotron as an accelerator (for example, Japanese Patent Application Laid-Open No. 2011-2011). No. 92424 is known).
  • a particle beam irradiation system having a synchrotron includes an ion source, a linear accelerator, a synchrotron, a high energy beam transport system (hereinafter referred to as a HEBT system), a gantry beam transport system (hereinafter referred to as a GABT system), a rotating gantry, and an irradiation device.
  • a HEBT system high energy beam transport system
  • GABT system gantry beam transport system
  • a rotating gantry a rotating gantry
  • an irradiation device Prepare.
  • a proton ion beam (or carbon ion beam) accelerated to a set energy by a synchrotron via a linear accelerator is emitted to the HEBT system, and reaches an irradiation device attached to the rotating gantry via the GABT system.
  • a proton ion beam (hereinafter referred to as “ion beam”) is irradiated from the irradiation device to a cancerous part of
  • the particle beam irradiation system having a cyclotron includes an ion source, a cyclotron, a HEBT system, a GABT system, a rotating gantry, and an irradiation device.
  • the HEBT system, the GABT system, the rotating gantry and the irradiation device in the particle beam irradiation system having a cyclotron are substantially the same as those structures in the particle beam irradiation system having a synchrotron.
  • the ion beam accelerated and emitted by the cyclotron is irradiated to the affected part from the irradiation device through the HEBT system and the GABT system.
  • a scatterer method and a beam scanning method as main irradiation methods of an ion beam to an affected part of cancer.
  • Each of the scatterer method and the beam scanning method is applied to a particle beam irradiation system having a synchrotron and a particle beam irradiation system having a cyclotron.
  • the ion beam is expanded in the direction perpendicular to the central axis of the irradiation device using a scatterer installed in the irradiation device, and the affected portion is irradiated with an ion beam cut out according to the cross-sectional shape of the affected portion by a collimator.
  • an ion beam is scanned in a direction perpendicular to the central axis of the irradiation apparatus in accordance with the shape of the affected area by a scanning electromagnet installed in the irradiation apparatus, and the affected area is irradiated with this ion beam.
  • JP-A-10-118204 examples include JP-A-2004-358237, and JP-A-2011-177374.
  • JP-A-10-118204 discloses a plurality of irradiation positions in a layer by scanning a thin ion beam in a direction perpendicular to the irradiation direction with respect to each layer of a cancer affected part divided into a plurality in the irradiation direction of the ion beam.
  • JP-A-10-118204 examples include JP-A-10-118204, JP-A-2004-358237, and JP-A-2011-177374.
  • These publications disclose a plurality of irradiation positions in a layer by scanning a thin ion beam in a direction perpendicular to the irradiation direction with respect to each layer of a cancer affected part divided into a plurality in the irradiation direction of the ion beam.
  • the movement of the ion beam to the next irradiation position in the layer is performed by controlling a scanning electromagnet that changes the position of the ion beam by a scanning control device.
  • the ion beam is moved from the deep layer to the shallow layer (or from the shallow layer to the deep layer) by changing the energy of the ion beam with an accelerator or a degrader. As the energy of the ion beam increases, the Bragg peak of the ion beam reaches a deeper position in the human body.
  • the ion beam emitted from the accelerator to the HEBT system passes through the central axis of the irradiation device in order to accurately irradiate the affected part with the ion beam.
  • the steering electromagnet controller adjusts the excitation current supplied to the steering electromagnet provided in the HEBT system based on the beam position measured by the beam position monitor provided in the HEBT system. Further, the excitation current supplied to the steering electromagnet provided in the GABT system is adjusted based on the beam position detection signal of the beam position monitor provided in the irradiation device. By controlling the excitation current to the HEBT steering electromagnet, the beam trajectory in the HEBT system can be adjusted to the set position (for example, the center position) of the entrance of the GABT system rotated by the rotating gantry.
  • the beam trajectory in the GABT system is adjusted so that the ion beam passes through the central axis of the irradiation device by controlling the excitation current to the GABT steering electromagnet by the steering electromagnet controller.
  • the beam trajectory is adjusted for each predetermined rotation angle of the rotating gantry.
  • Japanese Patent Application Laid-Open No. 2011-5096 describes beam trajectory adjustment performed after treatment of an affected area using an ion beam emitted from an accelerator is started. After the treatment of the affected area by the ion beam is started, the installation state of each device of the particle beam therapy system gradually changes and the beam trajectory also gradually changes due to the change of the building where the particle beam therapy system is installed. In order to correct such a change in the beam trajectory after the start of treatment, the GABT system is provided based on the beam position measured by the beam position monitor provided in the irradiation apparatus before irradiation of the ion beam to the patient. The excitation current of each steering electromagnet is corrected.
  • the beam trajectory is adjusted after the treatment using the ion beam is started.
  • the beam trajectory is adjusted by adjusting the excitation current of the GABT steering electromagnet based on the beam position measured by the beam position monitor provided in the irradiation apparatus.
  • Adjustment of the beam trajectory of the particle beam irradiation system after the start of treatment is desired to be performed in a short time in order to avoid a long period during which the irradiation of the ion beam to the affected area by the particle beam irradiation system is stopped. .
  • An object of the present invention is to provide a particle beam irradiation system that can shorten the time required for beam trajectory adjustment after the start of treatment.
  • a first beam transport system having a first steering electromagnet and a second steering electromagnet disposed along the first beam path through which the ion beam is emitted from the accelerator; and With rotating gantry, A second beam transport system attached to the rotating gantry and having a second beam path communicated with the first beam path and a third steering electromagnet and a fourth steering electromagnet disposed along the second beam path; An irradiation device attached to the rotating gantry and connected to the second beam path; First and second beam position measuring devices spaced apart from each other along the first beam path downstream of the first and second steering electromagnets; A third and a fourth beam position measuring device, which are spaced apart from each other in the irradiation device; And an excitation current calculation device for calculating a first excitation current for the first steering electromagnet and a second excitation current for the second steering electromagnet based on each beam position measured by the third and fourth beam position measuring devices.
  • the time required for adjusting the beam trajectory after the start of treatment can be shortened.
  • FIG. 2 is an enlarged vertical sectional view of the rotating gantry shown in FIG. 1.
  • FIG. 3 is a view taken in the direction of arrows III-III in FIG. 2.
  • FIG. 2 is a detailed configuration diagram of an accelerator / beam transport system control device, a gantry control device, and a scanning control device included in the control system shown in FIG. 1.
  • FIG. 2 is a detailed configuration diagram of a central control device included in the control system shown in FIG. 1.
  • 2 is a flowchart showing a part of a procedure for beam trajectory adjustment performed during a trial run in the particle beam irradiation system shown in FIG. 1.
  • FIG. 2 is a flowchart showing the remaining part of a procedure for beam trajectory adjustment performed during a trial run in the particle beam irradiation system shown in FIG. 1.
  • FIG. It is a flowchart which shows the procedure of the beam trajectory adjustment implemented after the treatment start in the particle beam irradiation system shown by FIG.
  • It is an example of the data obtained by the beam trajectory adjustment performed during the trial operation period of the particle beam irradiation system, and is an explanatory diagram showing the excitation current of the steering electromagnet for each angle of the rotating gantry.
  • It is explanatory drawing which is an example of the data obtained by the beam trajectory adjustment implemented in the period of trial operation, and shows the beam position in the position of the beam position monitor of the irradiation apparatus with respect to each energy.
  • FIG. 15 is a detailed configuration diagram of an accelerator / beam transport system control device, a gantry control device, and a scanning control device included in the control system shown in FIG. 14.
  • FIG. 15 is a detailed configuration diagram of a central control device included in the control system shown in FIG. 14.
  • FIG. 15 is a flowchart showing the remaining part corresponding to FIG.
  • FIG. 20 is a detailed configuration diagram of an accelerator / beam transport system control device, a gantry control device, and a scanning control device included in the control system shown in FIG. 19.
  • FIG. 20 is a flowchart showing a part of a procedure for beam trajectory adjustment performed during a trial run in the particle beam irradiation system shown in FIG. 19.
  • FIG. 20 It is a flowchart which shows the procedure of the beam trajectory adjustment implemented after the treatment start in the particle beam irradiation system shown by FIG.
  • the particle beam irradiation system includes a beam path 16 of the HEBT system 15 and a beam path 21 of the GABT system 20 connected to an accelerator (for example, one of a synchrotron accelerator and a cycletron accelerator). And an irradiation device 29 connected to the beam path 21.
  • the GABT system 20 and the irradiation device 29 are installed in a rotating gantry (not shown). Steering electromagnets HH 1 and HH 2 and beam position monitors HP 1 and HP 2 are arranged along the beam path 16.
  • Reference numeral 35 denotes a joint portion between the HEBT system 15 and the GABT system 20.
  • the inventors realize a particle beam irradiation system capable of accurately adjusting the beam trajectory even when the ion beam is deviated from the central axis of the irradiation device after the treatment of the affected area by the particle beam irradiation system is started.
  • Various studies were conducted for this purpose.
  • the inventors found that the cause of the ion beam deviating from the central axis in a plane perpendicular to the central axis of the irradiation device 29 after the start of treatment of the patient after the completion of the building where the particle beam irradiation system is installed. It has been found that the beam path 16 of the HEBT system 15 is deformed due to distortion due to passage of time. The deformation of the beam path 16 of this HEBT system is not visible and is actually very slight.
  • the rotating gantry itself has high rigidity and its support structure is strong, the inventors are hardly affected by the above-described distortion of the building, and the GABT system 20 and the irradiation device 29 attached to the rotating gantry have the above-mentioned. It has also been newly found that no deformation based on the distortion or the like occurs. Since the GABT system 20 and the irradiation device 29 are not deformed due to the distortion of the building or the like, the inventors, when the beam path 16 of the HEBT system 15 is deformed due to the distortion or the like of the building, the HEBT system 15 at the joint portion 35.
  • the inventors As a result of examination in consideration of the above newly found knowledge, the inventors, as described below, have started the treatment of the patient with ion beam irradiation, and then the beam of the HEBT system 15 due to distortion of the building or the like. It has been found that a particle beam irradiation system capable of accurately adjusting the beam trajectory can be realized even when the path 16 is deformed. In addition, since the beam trajectory is adjusted after the start of treatment, it is desired to shorten the time required for the beam trajectory adjustment. In order to realize such a particle beam irradiation system, in the adjustment of the beam trajectory after the start of treatment, the beam position measured by the beam position monitor of the irradiation apparatus is used. Instead of adjusting the excitation current (excitation amount) supplied to the GABT steering electromagnet as described, the excitation current supplied to the HEBT steering electromagnet may be adjusted.
  • the steering electromagnets HH1 and HH2 each have a pair of steering electromagnets as described in Japanese Patent No. 4299269.
  • the steering electromagnet HH1 is, as a pair of steering electromagnets, an X direction steering electromagnet that adjusts the position of the ion beam in the horizontal direction (X direction) in a plane perpendicular to the beam path 16, and an orthogonal to the horizontal direction in the vertical plane.
  • a Y-direction steering electromagnet that adjusts the position of the ion beam in the direction of movement (Y-direction).
  • the steering electromagnet HH2 includes a pair of steering electromagnets, an X-direction steering electromagnet and a Y-direction steering electromagnet.
  • each of the beam position monitors HP1 and HP2 is a pair of beam position monitors, an X-direction beam position monitor that measures the position of the ion beam in the X direction, and an ion in the Y direction. It has a Y-direction beam position monitor that measures the position of the beam.
  • the beam trajectory adjustment for the HEBT system and GABT system joint 35 is carried out during the trial operation period of the particle beam irradiation system after the installation of the particle beam irradiation system, and further the beam trajectory adjustment in the GABT system is performed. Is done.
  • an ion beam is emitted from the accelerator to the beam path 16.
  • the beam position in each of the X direction and Y direction of the ion beam emitted to the beam path 16 is measured by each of the beam position monitors HP1 and HP2 with the rotating gantry rotated to any arbitrary rotation angle.
  • the passing position of the ion beam at the entrance of the beam path 21 in the joint portion 35 is obtained.
  • the ion beam passage position at the entrance of the beam path 21 is deviated from the set position at the entrance of the beam path 21, this deviation is compensated for and the ion beam passage position at the entrance of the beam path 21 is set to the set position (
  • the respective excitation currents of the X-direction steering electromagnet and the Y-direction steering electromagnet included in each of the steering electromagnets HH1 and HH2 that match the central position of the entrance of the beam path 21 are calculated.
  • the above-described excitation current calculated for each of these steering electromagnets is a value at the aforementioned arbitrary rotation angle of the rotating gantry.
  • the adjustment of the beam trajectory with respect to the joint portion 35 is performed for each set energy of the ion beam, and the X of each of the steering electromagnets HH1 and HH2 is set for each set energy at an arbitrary certain rotation angle described above.
  • Each excitation current supplied to the direction steering electromagnet and the Y direction steering electromagnet is calculated. In this way, the adjustment of the beam trajectory with respect to the HEBT system and GABT system joint 35 is completed.
  • steering electromagnets GH1 and GH2 are arranged along the beam path 21 of the GABT system 20, and beam position monitors PRM and SPM are arranged. Is installed in the irradiation device 29.
  • Each of the steering electromagnets GH1 and GH2 also has a pair of steering electromagnets.
  • the steering electromagnet GH1 is a pair of steering electromagnets, an X direction steering electromagnet that adjusts the position of the ion beam in the horizontal direction (X direction) in a plane perpendicular to the beam path 21, and a horizontal direction in the vertical plane.
  • a Y-direction steering electromagnet that adjusts the position of the ion beam in the orthogonal direction (Y direction) is provided.
  • the steering electromagnet GH2 includes a pair of steering electromagnets, an X-direction steering electromagnet and a Y-direction steering electromagnet.
  • Each of the X direction in the plane perpendicular to the beam path 21 and the Y direction orthogonal to the X direction is a direction when the rotation angle of the rotating gantry is 0 °.
  • Each of the beam position monitors PRM and SPM is also a pair of beam position monitors, as described in Japanese Patent No. 4299269, and an X direction beam position monitor and a Y direction that measure the position of the ion beam in the X direction. And a Y-direction beam position monitor for measuring the position of the ion beam.
  • the X direction and the Y direction in the irradiation device 29 are directions in a plane perpendicular to the central axis of the irradiation device 29.
  • the X direction in the irradiation device 29 corresponds to the horizontal direction (X direction) in each plane perpendicular to the beam paths 16 and 21 described above
  • the Y direction in the irradiation device 29 corresponds to the beam path described above. This corresponds to the direction (Y direction) orthogonal to the horizontal direction in each plane perpendicular to 16 and 21.
  • the ion beam emitted from the accelerator reaches the irradiation device 29 through the beam paths 16 and 21.
  • Each of the beam position monitors PRM and SPM attached to the irradiation device 29 measures the beam position in each of the X direction and the Y direction of the ion beam at each position where the beam position monitors PRM and SPM are arranged. Based on these measured beam positions, the respective gradients of the beam trajectories in the X direction and Y direction in the irradiation device 29 are obtained in the same manner as the beam trajectory adjustment for the joint portion 35 described above.
  • the respective gradients of the beam trajectories in the X direction and the Y direction are not 0, and the displacement from the central axis of the irradiation device 29 in the X direction and the Y direction is 0 at each position where the beam position monitors PRM and SPM are respectively arranged. Otherwise, the respective excitation currents of the X-direction steering electromagnet and the Y-direction steering electromagnet included in each of the steering electromagnets GH1 and GH2 are calculated so that each gradient and each displacement become 0, respectively.
  • the beam trajectory adjustment in the GABT system is performed for each set rotation angle of the rotating gantry for each set energy of the ion beam, and the steering electromagnet for each set rotation angle for each set energy.
  • Each excitation current supplied to the X direction steering electromagnet and the Y direction steering electromagnet of GH1 and GH2 is calculated. In this way, adjustment of the beam trajectory in the GABT system is completed.
  • the respective excitation currents of the X-direction steering electromagnet and the Y-direction steering electromagnet of the steering electromagnets HH1 and HH2 at the reference rotation angle are performed.
  • Steering electromagnets GH1 and GH2 for each X-direction steering for each beam position in the X-direction and Y-direction at the respective positions of the beam position monitors PRM and SPM at the reference rotation angle and for each set rotation angle of the rotating gantry Information of each excitation current of the electromagnet and the Y-direction steering electromagnet is stored in the above-described storage device as a rotation angle table for each set energy of the ion beam.
  • the ion beam is irradiated onto the affected area of the patient using the particle beam irradiation system, and the affected area is treated.
  • the beam trajectory is adjusted in the particle beam irradiation system in order to compensate for the deviation of the ion beam from the central axis of the irradiation device 29.
  • the ion beam emitted from the accelerator reaches the irradiation device 29 through the beam paths 16 and 21, and the position of the ion beam in the irradiation device 29 is measured by the beam position monitors PRM and SPM, respectively. Is done.
  • the rotating gantry is rotated to any one of the aforementioned rotation angles.
  • the respective gradients of the beam trajectories in the X direction and the Y direction in the irradiation device 29 obtained based on the respective beam positions measured by these beam position monitors are not 0, and the beam position monitors PRM and SPM respectively.
  • Adjustment of the beam trajectory after the start of treatment is performed for each set energy of the ion beam, and the X direction steering electromagnet and the Y direction steering electromagnet of the steering electromagnets HH1 and HH2 for each energy set at the reference rotation angle. Each excitation current supplied to is calculated. In this way, adjustment of the beam trajectory after the start of treatment is completed.
  • a particle beam irradiation system according to a first embodiment which is a preferred embodiment of the present invention will be described below with reference to FIGS.
  • the particle beam irradiation system 1 of the present embodiment is placed in a building (not shown) and installed on the floor of the building.
  • the particle beam irradiation system 1 includes an ion beam generator 2, a high energy beam transport system (HEBT system) 15, a gantry beam transport system (GABT system) 20, a rotating gantry 26, an irradiation apparatus 29, and A control system 59 is provided.
  • a proton ion beam is used as an ion beam irradiated to a cancer affected part (beam irradiation target).
  • a carbon ion beam may be used instead of the proton ion beam.
  • the ion beam generator 2 includes an ion source (not shown), a linear accelerator 14 which is a pre-stage accelerator, and a synchrotron accelerator 3.
  • the synchrotron accelerator 13 includes an annular beam duct 4 that constitutes an orbit of the ion beam, an injector 5, a high-frequency acceleration cavity (high-frequency accelerator) 8 that applies a high-frequency voltage to the ion beam, a plurality of deflection electromagnets 6, a plurality The quadrupole electromagnet 7, the high frequency application device 9 for emission, and the septum electromagnet 13 for emission.
  • the injector 5 connected to the beam duct 4 is connected to the linear accelerator 14 by a vacuum duct.
  • An ion source is also connected to the linear accelerator 14.
  • the high-frequency applying device 9 includes an output high-frequency electrode 10, a high-frequency power source 11, and an open / close switch 12.
  • the emission high-frequency electrode 10 is attached to the annular beam duct 4 and is connected to a high-frequency power source 11 via an open / close switch 12.
  • Each deflection electromagnet 6, each quadrupole electromagnet 7, the high-frequency acceleration cavity 8, and the septum electromagnet 13 are disposed along the beam duct 4 as shown in FIG. 1.
  • each deflection electromagnet 6, each quadrupole electromagnet 7, and septum electromagnet 13 are connected to separate power sources 55.
  • the high frequency acceleration cavity 8 is connected to the high frequency power supply device 57.
  • the HEBT system (first beam transport system) 15 has a beam path (beam duct) 16 connected to the septum electromagnet 13 of the synchrotron accelerator 13, and from the synchrotron accelerator 3 along the beam path 16.
  • a plurality of quadrupole electromagnets 18, a deflection electromagnet 17, a plurality of quadrupole electromagnets 19, a steering electromagnet HH1 (first steering electromagnet), a steering electromagnet HH2 (second steering electromagnet), a beam position monitor HP1 (first) 1 beam position measuring device) and a beam position monitor HP2 (second beam position measuring device) are arranged.
  • the quadrupole electromagnet 19 is also disposed between the steering electromagnet HH1 and the steering electromagnet HH2.
  • the steering electromagnets HH1 and HH2 include an X-direction steering electromagnet and a Y-direction steering electromagnet, respectively.
  • the deflection electromagnet 17 and the quadrupole electromagnets 18 and 19 are connected to separate power sources 56 as shown in FIG. 4A.
  • the steering electromagnet HH1 is connected to the power source 58A
  • the steering electromagnet HH2 is connected to the power source 58B.
  • Each of the beam position monitors HP1 and HP2 is disposed closer to the mating portion 35 side of the HEBT system 15 and the GABT 20 system than the steering electromagnet HH2.
  • the GABT system (second beam transport system) 20 has a beam path (beam duct) 21, and along the beam path 21, a deflecting electromagnet 22 and a plurality of electromagnets 22 from the synchrotron accelerator 3 toward the irradiation device 29.
  • a 4-pole electromagnet 25, a steering electromagnet GH1 (third steering electromagnet), a steering electromagnet GH2 (fourth steering electromagnet), and deflection electromagnets 23 and 24 are arranged.
  • the quadrupole electromagnet 25 is also disposed between the steering electromagnet HH1 and the steering electromagnet HH2.
  • the steering electromagnets GH1 and GH2 also have an X-direction steering electromagnet and a Y-direction steering electromagnet, respectively.
  • the beam path 21 is installed in the rotating gantry 26.
  • the deflecting electromagnets 22 to 25, the plurality of quadrupole electromagnets 25, and the steering electromagnets GH1 and GH2 are also installed in the rotating gantry 26.
  • the beam path 21 is connected to the beam path 16 at the joint 35. Since the beam path 21 is rotated by the rotating gantry 26, the beam path 21 is not directly connected to the beam path 16.
  • the deflection electromagnets 22-24 and the quadrupole electromagnet 25 are connected to separate power sources 56 as shown in FIG. 4A.
  • the steering electromagnet GH1 is connected to the power source 58C
  • the steering electromagnet GH2 is connected to the power source 58D.
  • the irradiation device 29 includes two scanning magnets (ion beam scanning devices) 30 and 31, beam position monitors PRM and SPM, and a dose monitor 32.
  • the irradiation device 29 is attached to the rotating gantry 26 and is arranged downstream of the deflection electromagnet 24.
  • the scanning electromagnets 30 and 31, the beam position monitor PRM (third beam position measuring device), the beam position monitor SPM (fourth beam position measuring device), and the dose monitor 32 are arranged in this order in the casing (not shown) of the irradiation device 29. It is arranged along the central axis of the irradiation device 29 from the deflection electromagnet 24 toward the exit of the irradiation device 29.
  • the scanning electromagnet 30 deflects the ion beam in a plane perpendicular to the central axis of the irradiation device 29 and scans in the X direction, and the scanning electromagnet 31 deflects the ion beam in the plane and in the Y direction orthogonal to the X direction. Scan.
  • the treatment table 33 on which the patient 34 lies is disposed so as to face the irradiation device 29.
  • the control system 59 includes a central controller 60, an accelerator / transport system controller 64, a gantry controller 73, a scanning controller 76, and a database 81 (see FIG. 1).
  • the central controller 60 has a central processing unit (CPU) 61 and a memory 62 connected to the CPU 61.
  • the CPU 61 includes an irradiation control device 93, a beam trajectory adjusting device 94 (second beam trajectory adjusting device), and a beam trajectory adjusting device 98 (first beam trajectory adjusting device) (see FIG. 1).
  • the accelerator / transport system control device 64, the gantry control device 73, and the scanning control device 76 are connected to the irradiation control device 93, the beam trajectory adjustment device 94, and the beam trajectory adjustment device 98 of the CPU 61, respectively.
  • the database 81 is connected to the irradiation control device 93.
  • the particle beam irradiation system 1 includes a treatment planning device 82, and the treatment planning device 82 is connected to a database 81.
  • the beam trajectory adjusting device 94 includes a trajectory adjusting control device 95 (second trajectory adjusting control device), an excitation current calculating device 63 (second exciting current calculating device), and a table creating device 96.
  • the beam trajectory adjusting device 97 includes a trajectory adjusting control device 98 (first trajectory adjusting control device), an exciting current calculating device 70 (first exciting current calculating device), and an exciting current updating device 99.
  • the irradiation control device 93, the trajectory adjustment control devices 95 and 98, the excitation current calculation devices 63 and 70, the table creation device 96 and the excitation current update device 99 are connected to the memory 62.
  • the input device 100 is connected to the irradiation control device 93 and the trajectory adjustment control devices 95 and 98 (see FIG. 4B).
  • the beam trajectory adjustment device 94 adjusts the beam trajectory during the trial run after the particle beam irradiation system 1 is installed.
  • the beam trajectory adjustment device 97 adjusts the beam trajectory after the treatment of the affected area by the particle beam irradiation system 1 is started.
  • the irradiation control device 93 performs control to irradiate the affected part which is a beam irradiation target at the time of treatment with an ion beam.
  • the accelerator / transportation system control device 64 includes an electromagnet control device 65, a high frequency voltage control device 66, an emission control device 67, a beam position input device 68, a steering electromagnet control device 69, an energy determination device 71, and a memory. 72.
  • the gantry control device 73 includes a rotation control device 74, a rotation angle determination device 75, and a rotation angle setting device 52, as shown in FIG. 4A.
  • the scanning control device 76 includes an irradiation position control device 77, a dose determination device 78, a layer determination device 79, and a memory 80, as shown in FIG. 4A.
  • the irradiation control device 93 includes an electromagnet control device 65, a high-frequency voltage control device 66, an emission control device 67, a steering electromagnet control device 69, a memory 72, a rotation control device 74, an irradiation position control device 77, a dose determination device 78, and a layer determination device. 79 and the memory 80, respectively.
  • the trajectory adjustment control device 95 includes an electromagnet control device 65, a high frequency voltage control device 66, an emission control device 67, a beam position input device 68, a steering electromagnet control device 69, an energy determination device 71, a memory 72, a rotation control device 74, and a rotation angle.
  • the determination device 75 and the rotation angle setting device 52 are connected to each other.
  • the trajectory adjustment control device 98 includes an electromagnet control device 65, a high frequency voltage control device 66, an emission control device 67, a beam position input device 68, a steering electromagnet control device 69, an energy determination device 71, a memory 72, and a rotation control device 74, respectively. Connected.
  • the beam position input device 68 is connected to beam position monitors HP1, HP2, PRM and SPM.
  • An angle detector 28 (see FIG. 2) is connected to the rotation angle determination device 75.
  • An irradiation position control device 77 is connected to the electromagnet control device 65, the high frequency voltage control device 66, the emission control device 67, and the steering electromagnet control device 69.
  • a dose determination device 78 is connected to the emission control device 67.
  • a dose monitor 32 is connected to the dose determination device 78.
  • the rotating gantry 26 will be described with reference to FIGS.
  • the rotating gantry 26 is rotatable in a range of 360 ° and includes a cylindrical rotating drum 36 having a ring-shaped front ring 37 and a rear ring 38.
  • the front ring 37 is supported by a support device 39A installed on the floor surface 43 of the building, and the rear ring 38 is supported by a support device 39B installed on the floor surface 43 thereof.
  • the support device 39A includes a roll support member 40 and a plurality of support rollers 41A.
  • the plurality of support rollers 41 ⁇ / b> A are rotatably attached to the roll support member 40.
  • the front ring 37 is supported by these support rollers 41A.
  • the support device 39B also includes a roll support member 40 (not shown) and a plurality of support rollers 41B.
  • the plurality of support rollers 41 ⁇ / b> B are rotatably attached to the roll support member 40.
  • the rear ring 38 is supported by these support rollers 41B.
  • a rotating device (for example, a motor) 42 that rotates the rotating gantry 26 is coupled to the rotating shaft of one of the support rollers 41B that supports the rear ring 38.
  • An angle detector 28 that measures the rotation angle of the rotating gantry 26 is connected to the rotating shaft of one of the support rollers 41A that supports the front ring 37. In FIG. 1, the angle detector 28 is shown in contact with the beam path 21, but this schematically shows the arrangement of the angle detector 28.
  • a treatment room 45 supported by a plurality of support members 48 attached to the inner surface of the rotary drum 36 is provided in the rotary drum 36.
  • the front ring 37 side of the treatment room 45 is open, and the rear ring 38 side of the treatment room 45 is sealed by a partition wall 47.
  • the irradiation device 29 is attached to the rotating drum 36 and extends toward the center of the rotating drum 36, and reaches the treatment cage 49 in the treatment room 45.
  • the beam path 21 of the GABT system 20 connected to the irradiation device 29 extends toward the rear ring 38, and the HEBT system 15 is located at the mating portion 35 located outside the rotating gantry 26.
  • the center line 27 (see FIGS. 1 and 2) of the rotating gantry 26 is the rotating center of the rotating gantry 26 and passes through the center of the entrance of the beam path 21 at the joint portion 35.
  • the treatment table 33 is installed on the bed 50 and the three-way drive mechanism 53 and the three-way drive mechanism 53 installed in the treatment table mounting region 44 that is higher than the floor surface 43.
  • the rotary drive mechanism 54 has a bed 50 attached to the rotary drive mechanism 54.
  • the beam trajectory adjustment method in the particle beam irradiation system 1 of the present embodiment will be described with reference to FIGS.
  • a beam trajectory adjustment method in a trial operation period after the installation of the particle beam irradiation system 1 is completed will be described with reference to FIGS. 5 and 6.
  • a first beam trajectory adjustment program showing a procedure including steps S1 and S3 to S24 shown in FIGS. 5 and 6 is stored in the memory 62.
  • the memory 62 also has a second beam trajectory adjustment program showing a procedure including steps S23, S4, S5, S27, S7, S8, S16, S10, S28, S29 and S30 shown in FIG. It is remembered.
  • the trajectory adjustment control device 95 stores the beam trajectory in the trial run period stored in the memory 62.
  • the first beam trajectory adjustment program for performing the adjustment is selected, and the control devices included in the accelerator / transportation system control device 64 and the gantry control device 73 are controlled based on the procedure of the first beam trajectory adjustment program.
  • the command information is output, and the beam trajectory adjustment during the test run is performed as follows.
  • step S1 The accelerator / transport system controller 64 that has received control command information from the trajectory adjustment controller 95 activates the ion source and the linear accelerator 14. Ions (for example, protons) generated in the ion source enter the linear accelerator 14 and are accelerated. A proton ion beam (hereinafter simply referred to as an ion beam) emitted from the linear accelerator 14 is incident on the annular beam duct 4 of the synchrotron accelerator 3 through the injector 5. The ion beam circulates in the beam duct 4.
  • an ion beam (hereinafter simply referred to as an ion beam) emitted from the linear accelerator 14 is incident on the annular beam duct 4 of the synchrotron accelerator 3 through the injector 5. The ion beam circulates in the beam duct 4.
  • the ion beam energy is set (step S2).
  • the operator enters the input device 10 From 0, for example, a maximum of 250 MeV is input as the energy of the ion beam emitted from the synchrotron accelerator 3.
  • This energy “250 MeV” is input to the trajectory adjustment control device 95 and set as the energy of the ion beam in the trajectory adjustment control device 95.
  • the rotation control device 74 that has received the control command information from the trajectory adjustment control device 95 drives the rotation device 42 to an arbitrary certain rotation angle (for example, 270 °) for adjusting the beam trajectory with respect to the joint portion 35.
  • the rotating gantry 26 is rotated, and the rotating gantry 26 is held at this angle. Any given rotation angle is one rotation angle within the rotation range 0 ° to 360 ° of the rotating gantry 26, and may be, for example, 0 ° or 10 °.
  • the rotation angle determination device 75 confirms that the rotation gantry 26 has rotated to 270 ° based on the angle measured by the angle detector 28.
  • the excitation current supplied to the electromagnet of the accelerator is controlled based on the set energy of the ion beam (step S4).
  • the electromagnet controller 65 to which the control command information is input from the trajectory adjustment controller 95 is supplied to each of the deflection electromagnet 6, the quadrupole electromagnet 6, and the septum electromagnet 13 arranged along the beam duct 4 by controlling the power supply 55.
  • the excitation current is adjusted to the excitation current corresponding to the ion beam energy (250 MeV) set in step S2.
  • the excitation current supplied to the electromagnet of the beam transport system is controlled based on the set energy of the ion beam (step S5).
  • the electromagnet controller 65 to which the control command information is input from the trajectory adjustment controller 95 controls the power supply 56 and is supplied to each of the deflecting electromagnet 17 and the quadrupole electromagnets 18 and 19 arranged along the beam path 16.
  • the excitation current and the excitation current supplied to each of the deflection electromagnets 22 to 24 and the quadrupole electromagnet 25 arranged along the beam path 21 are the excitation currents corresponding to the ion beam energy (250 MeV) set in step S2. Adjust to.
  • the exciting current supplied to the steering electromagnet is controlled (step S6).
  • the steering electromagnet controller 69 that has received the control command information from the trajectory adjustment controller 95 controls each of the power supplies 58A to 58D, and the excitation current is applied to the steering electromagnets HH1, HH2, GH1, and GH2, respectively, in the X direction steering electromagnet and the Y direction. Supply to the steering electromagnet.
  • the high-frequency voltage supplied to the high-frequency acceleration cavity is controlled based on the set energy of the ion beam (step S7).
  • the high-frequency voltage control device 66 that has received control command information from the trajectory adjustment control device 95 controls the high-frequency power supply device 57 to adjust the high-frequency voltage applied to the high-frequency accelerating cavity 8 and circulate in the beam duct 4. Is accelerated to 250 MeV, which is the set energy.
  • the ion beam is emitted from the accelerator (step S8).
  • the emission control device 67 that has received control command information from the trajectory adjustment control device 95 closes the open / close switch 12. For this reason, a high-frequency voltage from the high-frequency power source 11 is applied from the extraction high-frequency electrode 10 to the ion beam circulating in the beam duct 4.
  • the circulating ion beam is emitted from the synchrotron accelerator 3 to the beam path 16 through the septum electromagnet 13 by applying a high frequency voltage.
  • the extracted ion beam reaches the irradiation device 29 through the beam paths 15 and 21.
  • the beam position is measured with a HEBT beam position monitor (step S9).
  • Each of the beam position monitors HP1 and HP2 arranged in the beam path 16 measures the beam position in each of the X direction and the Y direction of the ion beam passing through the beam path 16.
  • the beam position input device 68 that has received the control command information from the trajectory adjustment control device 95 inputs the respective beam positions in the X and Y directions measured by the beam position monitors HP1 and HP2, respectively. The position is stored in the memory 72.
  • the extraction of the ion beam from the accelerator is stopped (step S10).
  • the emission control device 67 that has received the control command information from the trajectory adjustment control device 95 opens the open / close switch 12. For this reason, the application of the high-frequency voltage from the high-frequency power source 11 to the extraction high-frequency electrode 10 is stopped, and the extraction of the ion beam from the synchrotron accelerator 3 to the beam path 16 is stopped.
  • the excitation current of the HEBT steering electromagnet is calculated (step S11).
  • the excitation current calculation device 63 that has received control command information from the trajectory adjustment control device 95 uses the respective beam positions (stored in the memory 72) in the X direction and Y direction measured by the beam position monitors HP1 and HP2, respectively.
  • Each step of steps S20 to S70 (see paragraphs 0086 to 0089 and FIG. 4) described in Japanese Patent No. 4299269 is performed, and the X direction of each of the steering electromagnets HH1 and HH2 in which the displacement is 0 and the gradient is 0
  • the kick amounts of the steering electromagnet and the Y-direction steering electromagnet are obtained.
  • the respective excitation currents for obtaining the respective kick amounts of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets HH1 and HH2 are the respective X-direction steering electromagnets and Y-direction steering electromagnets of the steering electromagnets HH1 and HH2. Excitation current.
  • the calculated excitation currents are stored in the memory 72 in association with the ion beam energy (250 MeV) and the steering electromagnet.
  • Each excitation current of the HEBT type steering electromagnet is stored in the memory (step S12).
  • the excitation current calculation device 63 obtains the information of the excitation current for each 250 MeV of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets HH1 and HH2 calculated in step S11, and the energy and each of the steering electromagnets. And stored in the memory 62 of the central controller 60 from the memory 72.
  • the rotating gantry 26 is rotated by a predetermined angle (for example, 1 °) in the range of 0 ° to 360 °.
  • the rotation control device 74 that has received control command information from the trajectory adjustment control device 95 drives the rotation device 42 to rotate the rotation gantry 26 to a new set rotation angle, for example, 0 °. That the rotating gantry 26 has been rotated to 0 ° is confirmed by a rotation angle determination device 75 that inputs an angle measured by the angle detector 28.
  • the excitation current supplied to the steering electromagnet is controlled (step S14).
  • the steering electromagnet controller 69 that has received the control command information from the track adjustment controller 95 calculates the X-direction steering electromagnet and the Y-direction steering electromagnet of the steering electromagnets HH1 and HH2 calculated in step S10 and stored in the memory 72, respectively.
  • Each of the power supplies 58A and 58B is controlled so that the excitation current for each 250 MeV is supplied to these steering electromagnets.
  • the respective excitation currents having the current values calculated in step S10 are supplied to the respective X-direction steering electromagnets and Y-direction steering electromagnets of the steering electromagnets HH1 and HH2.
  • the exciting current is supplied to each of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets GH1 and GH2 by the control of the power sources 58C and 58D by the steering electromagnet controller 69.
  • Step S15 is performed in the same manner as Step S8, and the ion beam emitted from the synchrotron accelerator 3 to the beam path 16 reaches the irradiation device 29 through the beam path 21. Since the respective excitation currents supplied to the X direction steering magnets and the Y direction steering magnets of the steering electromagnets HH1 and HH2 are controlled as in step 14, the ion beam passing through the beam path 16 is incident on the entrance of the beam path 21. Passes the center position that is the set position.
  • the beam position is measured by the beam position monitor of the irradiation device (step S16).
  • Each of the beam position monitors PRM and SRM attached to the irradiation device 29 measures the respective beam positions in the X direction and the Y direction of the ion beam passing along the central axis of the irradiation device 29.
  • the beam position input device 68 that has received the control command information from the trajectory adjustment control device 95 inputs the respective beam positions in the X direction and the Y direction measured by the beam position monitors PRM and SPM, respectively.
  • the beam position is stored in the memory 72.
  • Step S17 is performed in the same manner as Step S10, and the extraction of the ion beam from the synchrotron accelerator 3 to the beam path 16 is stopped.
  • An excitation current of the GABT steering electromagnet is calculated (step S18).
  • the excitation current calculation device 63 that receives the control command information from the trajectory adjustment control device 95 uses the respective beam positions (stored in the memory 72) in the X direction and Y direction measured by the beam position monitors PRM and SPM, respectively.
  • the steps S110 to S160 (see paragraphs 0093 to 0096 and FIG. 4) described in Japanese Patent No. 4299269 are performed, and the displacement of the beam position from the central axis of the irradiation device 29 is 0, and the gradient is 0.
  • the respective kick amounts of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets GH1 and GH2 are obtained.
  • the respective excitation currents for obtaining the respective kick amounts of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets GH1 and GH2, respectively, are the respective X-direction steering electromagnets and Y-direction steering electromagnets of the steering electromagnets GH1 and GH2.
  • These calculated excitation currents are stored in the memory 72 in association with the energy of the ion beam (for example, 250 MeV), the rotation angle of the rotating gantry 26 (for example, 0 °), and the steering electromagnet.
  • Each excitation current of the GABT steering electromagnet is stored in the memory (step S19).
  • the excitation current calculation device 63 obtains information on the excitation current for each 250 MeV of the X direction steering electromagnets and the Y direction steering electromagnets of the steering electromagnets GH1 and GH2 calculated in step S18, and the rotation angle of the rotating gantry 26 and those.
  • step S20 It is determined whether the adjustment of the beam trajectory in the GABT system has been completed over the entire range of the rotation angle of the rotating gantry (step S20).
  • the rotation angle determination device 75 that has received the control command information from the trajectory adjustment control device 95 determines whether the adjustment of the beam trajectory in the GABT system 20 has been completed over the entire range of the rotation angle of the rotating gantry 26. Since the adjustment of the beam trajectory at the rotation angle of 0 ° is completed, the determination in step S20 is “No”. In this embodiment, 0 ° to 360 ° is set as the entire range of the rotation angle of the rotating gantry 26, and the entire range of the rotation angle is stored in the memory 62. In addition, in a rotating gantry capable of rotating in the range of 180 °, the entire range of rotation angles is 0 ° to 180 °.
  • a new rotation angle is set (step S21).
  • the rotation angle setting device 52 sets a rotation angle of 0.5 ° as a new rotation angle.
  • the rotation control device 74 drives the rotating device 42 and rotates the rotating gantry 26 to a new set rotation angle (for example, 0.5 °) as in step S3.
  • steps S14 to S20 are performed.
  • steps S21 and S13 to S20 are repeated while increasing the set rotation angle by 0.5 ° until the rotation angle of the rotating gantry 26 reaches 360 °. To be implemented.
  • the determination in step S20 is “Yes”.
  • step S20 When the determination in step S20 is “Yes”, the set rotation angle (for example, 0.360 °) in the entire range (0 ° to 360 °) of the rotation angle of the rotating gantry 26 at one set energy (for example, 250 MeV). The adjustment of the beam trajectory in the GABT system 20 every 5 ° is completed.
  • a rotation angle table is created (step S22).
  • the table creating device 96 determines the excitation currents GH1 X , GH1 Y , and GH2 for each rotation angle of the rotating gantry 26 obtained in step S18 stored in the memory 62.
  • a rotation angle table for 250 MeV is created using X and GH2 Y.
  • An example of the rotation angle table for 220 MeV is shown in FIG.
  • the rotation angle table created for 250 MeV is the excitation current of the X-direction steering electromagnet and the Y-direction steering electromagnet of the steering electromagnet GH1 every 0.5 ° within the rotation angle range of 0 ° to 360 ° of the rotating gantry 26.
  • the excitation currents GH2 X and GH2 Y of the X direction steering electromagnet and the Y direction steering electromagnet of GH1 X and GH1 Y and the steering electromagnet GH2 are included.
  • the reference rotation angle is, for example, 270 ° for a rotating gantry rotatable in a range of 360 °, and 90 ° for a rotating gantry rotatable in a range of 180 °.
  • the rotation control device 74 that has received the control command information from the trajectory adjustment control device 95 drives the rotation device 42 to move the rotating gantry 26 to a reference rotation angle, for example, 270 °, for adjusting the beam trajectory with respect to the joint portion 35. Rotating, the rotating gantry 26 is held at this angle.
  • step S15 is performed after the process of step S23 is completed.
  • an ion beam is emitted from the synchrotron accelerator 3, as in step S8. This ion beam reaches the irradiation device 29.
  • the beam position is measured by the beam position monitor of the irradiation apparatus (step S24). With the rotating gantry 26 rotated to 270 °, each of the beam position monitors PRM and SRM is respectively in the X direction and Y direction of the ion beam passing along the central axis of the irradiation device 29, as in step S16. Measure the beam position.
  • the beam position input device 68 to which the control command information is input from the trajectory adjustment control device 95 receives the beam positions PRM X , PRM Y , SPM X in the X direction and Y direction measured by the beam position monitors PRM and SPM, respectively. and enter the SPM Y, it stores these beam position in the memory 72.
  • the beam positions PRM X , PRM Y , SPM X and SPM Y are stored in the memory 62 from the memory 72.
  • the beam positions PRM X , PRM Y , SPM X and SPM Y measured in step S24 are set to a rotation angle of 270 ° (reference rotation angle) included in the rotation angle table of 250 MeV as target beam positions for beam trajectory adjustment.
  • it is stored in the memory 62 (see FIG. 8).
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y of the steering electromagnet HH1 and the Y-direction steering electromagnet at 250 MeV obtained in step S11 are also stored in the memory 62 together with the rotation angle table of 250 MeV. Stored (see FIG. 8).
  • step S17 is performed.
  • step S17 extraction of the ion beam from the synchrotron accelerator 3 to the beam path 16 is stopped as in step S10.
  • step S2 the operator inputs from the input device 100, as the energy of the ion beam emitted from the synchrotron accelerator 3, 1 MeV smaller than 250 MeV, for example, the maximum 249 MeV.
  • step S ⁇ b> 2 249 MeV input from the input device 100 is set as new energy of the ion beam in the trajectory adjustment control device 95.
  • each step of Steps S3 to S12 (adjustment of the beam trajectory for the mating portion 35 of the HEBT system 15 and the GABT system 20) is performed as described above, and Step S13 is performed.
  • Steps S21 to S21 (adjustment of the beam trajectory in the GABT system 20) are performed as described above until the determination in step S20 becomes “Yes”.
  • Steps S13 to S21 are repeated until the determination in step S20 becomes “Yes”, thereby targeting 249 MeV every 0.5 ° within a rotation angle range of 0 ° to 360 ° of the rotating gantry 26.
  • the excitation current GH1 X and GH1 Y and the excitation current GH2 X and GH2 Y in the X direction steering magnet and the Y direction steering magnets steering electromagnet GH2 in the X direction steering magnet and the Y direction steering magnets steering electromagnet GH1 is calculated.
  • step S22 creation of the rotation angle table
  • step S23 rotation of the rotating gantry to the reference rotation angle
  • step S15 extraction of the ion beam
  • step S24 measurement of the beam position in the irradiation apparatus
  • step S17 stop of ion beam extraction
  • step S22 a rotation angle table for 249 MeV is created.
  • the beam positions PRM X , PRM Y , SPM X and SPM Y measured in step S24 in the irradiation device 29 are included in a rotation angle table of 249 MeV as target beam positions for beam trajectory adjustment.
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y at 249 MeV obtained in step S11 are also stored in the memory 62 together with the rotation angle table of 249 MeV.
  • step S2 energy of each ion beam reduced from 248 MeV to 150 MeV every 1 MeV is input from the input device 100 to set the energy of each ion beam, while decreasing by 1 MeV in the range of 248 MeV to 150 MeV.
  • Steps S3 to S12, Steps S13 to S21, Steps S22, S23, Step S15, Step S24, and Step S17 are repeatedly performed.
  • the rotation table information created for each energy includes excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y at the corresponding energy, and PRM X , PRM Y , which are target beam positions for beam trajectory adjustment. It is stored in the memory 62 in association with SPM X and SPM Y.
  • the excitation currents GH1 X and GH1 Y of the X direction steering electromagnet and the Y direction steering electromagnet of the steering electromagnet GH1 every 0.5 ° within the rotation angle 0 ° to 360 ° of the rotating gantry 26 shown in FIG.
  • the rotation angle table including the excitation currents GH2 X and GH2 Y of the X direction steering electromagnet and the Y direction steering electromagnet of the steering electromagnet GH2 is a rotation angle table when the energy is 220 MeV.
  • FIG. 8 also shows excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y when the energy is 220 MeV, and target beam positions PRM X , PRM Y , SPM X and SPM Y for beam trajectory adjustment. It is shown.
  • FIG. 9 shows the beam positions PRM X , PRM Y , SPM X and SPM Y for each set energy measured in step 16 when the rotation angle of the rotating gantry 26 is 270 °.
  • the ion beam is irradiated to the affected part of the patient 34 lying on the bed 50 of the treatment table 33 using the particle beam irradiation system 1 in which the beam trajectory is adjusted, and the affected part is treated. Done. Details of this treatment will be described later.
  • the beam trajectory of the particle beam irradiation system 1 is deformed by deformation of the beam path 16 of the HEBT system 15 due to distortion of the building or the like. Changes, and there is a possibility that irradiation of the affected part of the ion beam cannot be performed with high accuracy. For this reason, the beam trajectory of the particle beam irradiation system 1 is periodically adjusted while the particle beam irradiation system 1 is stopped. This beam trajectory adjustment will be described with reference to FIG.
  • the trajectory adjustment control device 98 When the operator inputs the second trajectory adjustment start signal from the input device 100 to the trajectory adjustment control device 98 of the beam trajectory adjustment device 97, the trajectory adjustment control device 98 is stored in the memory 62 and the beam trajectory after the start of treatment.
  • the second beam trajectory adjustment program for performing the adjustment is selected, and control command information is sent to each of the accelerator / transportation system control device 64 and the gantry control device 73 based on the procedure of the second beam trajectory adjustment program (see FIG. 7). Output to each control device included in the. For this reason, adjustment of the beam trajectory after the start of treatment is performed as follows.
  • step S1 activation of the ion source and the linear accelerator 14
  • step S23, S2, S4 and S5 shown in FIG. 7 are performed.
  • step S23 the rotating gantry 26 is rotated to the reference rotation angle of 270 ° by the rotation control device 74 that has received the control command information, as in step 23 shown in FIG. Thereafter, the rotating gantry 26 is held at the reference rotation angle of 270 °.
  • step S2 the energy (250 MeV) of the ion beam input by the operator from the input device 100 is set in the same manner as the beam trajectory adjustment during the trial operation described above.
  • Steps S4 and S5 are performed in steps S4 and S5 in the adjustment of the beam trajectory with respect to the joint portion 35 (FIG. 5) under the control of the electromagnet controller 65 that receives control command information from the trajectory adjustment controller 98. (See reference).
  • the exciting current supplied to the steering electromagnet is controlled (step S27).
  • the steering electromagnet controller 69 that has received the control command information from the trajectory adjustment control device 98 receives the respective excitation currents of the X-direction steering electromagnet and the Y-direction steering electromagnet of the steering electromagnets HH1 and HH2 for 250 MeV stored in the memory 62.
  • the excitation currents are adjusted to HH1 X , HH1 Y , HH2 X and HH2 Y.
  • the steering electromagnet control device 69 uses the respective excitation currents of the X direction steering electromagnets and the Y direction steering electromagnets of the steering electromagnets GH1 and GH2 at the rotation angle 270 ° of the rotation angle table of 250 MeV stored in the memory 62.
  • the exciting currents GH1 X , GH1 Y , GH2 X and GH2 Y are adjusted.
  • steps S7 and S8 are sequentially performed under the control of the high-frequency voltage controller 66 and the emission controller 67 that have received control command information from the trajectory adjustment controller 98.
  • a 250 MeV ion beam is emitted from the synchrotron accelerator 3 to the beam path 16, and this ion beam reaches the irradiation device 29 through the beam path 21.
  • the beam position is measured by the beam position monitor of the irradiation apparatus (step S16). Similar to step S16 that is implemented by adjusting the beam trajectory in the period of test operation, the beam position input device 68, measured by the respective beam position monitor PRM and SPM, each beam position PRM X in the X and Y directions , PRM Y , SPM X, and SPM Y are input, and the input beam positions are stored in the memory 72. Thereafter, step S10 is performed, and extraction of the ion beam from the synchrotron accelerator 3 to the beam path 16 is stopped.
  • the exciting current of the HEBT steering electromagnet is calculated (step S28).
  • the excitation current calculation device 70 that has received the control command information from the trajectory adjustment control device 98 is for 250 MeV in which the beam positions in the X direction and Y direction measured by the beam position monitors PRM and SPM, respectively, are stored in the memory 62.
  • the respective kick amounts of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets HH1 and HH2 are obtained so that the target beam position for beam trajectory adjustment is obtained.
  • the respective excitation currents for obtaining the respective kick amounts of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets HH1 and HH2 are the respective X-direction steering electromagnets and Y-direction steering electromagnets of the steering electromagnets HH1 and HH2.
  • the obtained excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are stored in the memory 62 in association with the energy and the steering electromagnet.
  • the calculation of the excitation current of each HEBT system steering electromagnet in step S28 is performed in the same manner as in step S18 using the beam positions measured by the beam position monitors PRM and SPM.
  • the respective excitation currents of the steering electromagnets HH1 and HH2 are updated (step S29).
  • the exciting current updating device 99 calculates each information of the exciting currents HH1 X , HH1 Y , HH2 X and HH2 Y with respect to 250 MeV of the X direction steering electromagnets and the Y direction steering electromagnets of the steering electromagnets HH1 and HH2 calculated in step S28. Is used to update the respective excitation currents of the steering electromagnets HH1 and HH2 with respect to 250 MeV stored in the memory 62. At this time, the rotation angle table information for each energy and the target beam position for beam trajectory adjustment stored in the memory 62 are not updated.
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y stored in the memory 62, the excitation currents GH1 X , GH1 Y , GH2 X and GH2 Y for each rotation angle of the rotating gantry 26, and Of the target beam positions PRM X , PRM Y , SPM X and SPM Y , only the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are updated.
  • step S2 the energy of each ion beam reduced from 249 MeV to 150 MeV every 1 MeV is input from the input device 100 and the energy of each ion beam is set, while decreasing by 1 MeV in the range of 249 MeV to 150 MeV.
  • Steps S4, S5, S27, S7, S8, S16, S10, S28 and S29 are repeatedly performed.
  • step S29 for 150 MeV the adjustment of the beam trajectory of the particle beam irradiation system 1 performed after the cancer treatment is started is completed.
  • the beam trajectory adjustment of the particle beam irradiation system 1 performed after the above-described cancer treatment is started is periodically performed as described above, and the beam position monitors PRM and SRM in step S16. This is performed even when the beam positions measured by the above are not deviated from the target beam position for beam trajectory adjustment.
  • a program showing a procedure including steps S1, S31 to S38, S7, S39, S9, S40 and S41 shown in FIG. 10 relating to the ion beam irradiation method is stored in the memory 62.
  • the irradiation control device 93 includes control command information in each of the accelerator / transportation system control device 64 and the gantry control device 73 based on this procedure. Output to each control device. For this reason, the treatment of the affected part using an ion beam is performed as follows.
  • Treatment plan data for each patient 34 who treats an affected area of cancer by irradiating an ion beam is created using the treatment planning device 82 before treatment.
  • This treatment plan data includes the patient identification number, the number of layers in the affected area divided in the depth direction from the patient's body surface, the energy of the ion beam irradiated for each layer, the irradiation direction of the ion beam, and the ions in each layer Data such as the irradiation position of the beam and the irradiation amount of the ion beam for each irradiation position in each layer are included and stored in the database 81.
  • the irradiation control device 93 reads the treatment plan data relating to the patient 34 to be treated from the database 81 using the input patient identification information and stores it in the memory 62.
  • the bed 50 of the treatment table 33 on which the patient 34 lies is moved, and the affected part of the patient 34 that is a beam irradiation target is positioned on the extension line of the central axis of the irradiation device 29.
  • the ion source and the linear accelerator are activated (step S1), and ions (for example, protons (or carbon ions)) generated in the ion source are incident on the linear accelerator 14, accelerated, and emitted from the linear accelerator 14.
  • ions for example, protons (or carbon ions)
  • the light enters the annular beam duct 4 of the synchrotron accelerator 3.
  • the central axis of the irradiation device is set to the ion beam irradiation direction (step S31).
  • the rotation control device 71 that has received the control command information from the irradiation control device 93 drives the rotation device 42 to rotate the rotating gantry 26, and reads the central axis of the irradiation device 29 from the memory 62, and treatment plan data for the patient 34. It is made to correspond to the irradiation direction of the ion beam.
  • One layer for ion beam irradiation is set (step S32).
  • the irradiation position control device 77 that has received control command information from the irradiation control device 93 sets one layer for irradiating the ion beam in the affected area.
  • the layer existing at the deepest position is set based on the information of a plurality of layers obtained by dividing the affected area, which is stored in the memory 62.
  • the irradiation position control device 77 retrieves energy information (for example, 220 MeV) of the ion beam irradiated to the set layer from the treatment plan data stored in the memory 62, and this energy information is retrieved from the electromagnet control device 65, Output to the steering electromagnet controller 69 and the high-frequency voltage controller 66.
  • energy information for example, 220 MeV
  • the exciting current supplied to the electromagnet of the accelerator is controlled (step S33).
  • the electromagnet control device 65 that has received control command information from the irradiation control device 93 controls the power supply 55 so that the excitation current supplied to each of the deflection electromagnet 6, the quadrupole electromagnet 6 and the septum electromagnet 13 is the excitation current corresponding to 220 MeV. Adjust to.
  • the excitation current supplied to the electromagnet of the beam transport system is controlled (step S34).
  • the electromagnet controller 65 that has received the control command information from the irradiation controller 93 controls the power supply 56, and the excitation current supplied to the respective deflection electromagnets and quadrupole electromagnets of the HEBT system 15 and the GABT system 20 corresponds to 220 MeV. Adjust the excitation current to
  • the exciting current supplied to the steering electromagnets HH1 and HH2 is controlled (step S35).
  • the steering electromagnet controller 69 that receives the control command information from the irradiation controller 93 controls the power supplies 58A and 58B, and supplies the X-direction steering electromagnet and the Y-direction steering electromagnet of the steering electromagnets HH1 and HH2, respectively.
  • the excitation current is adjusted to the updated excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y corresponding to 220 MeV stored in the memory 62.
  • the exciting current supplied to the steering electromagnets GH1 and GH2 is controlled (step S36).
  • the steering electromagnet controller 69 further controls each of the power supplies 58C and 58D, and supplies each excitation current supplied to the X-direction steering electromagnet and Y-direction steering electromagnet of the steering electromagnets GH1 and GH2 to a rotation angle table of 220 MeV.
  • a rotation angle table of 220 MeV are adjusted to the excitation currents GH1 X , GH1 Y , GH2 X, and GH2 Y included in.
  • the high frequency voltage supplied to the high frequency acceleration cavity is controlled (step S37).
  • the high-frequency voltage control device 66 that has received control command information from the irradiation control device 93 controls the high-frequency power supply device 57 based on 220 MeV to adjust the high-frequency voltage applied to the high-frequency acceleration cavity 8 and circulates in the beam duct 4. Accelerate the ion beam to 220 MeV.
  • the scanning electromagnet is controlled to set the irradiation position of the ion beam within the set layer (step S38).
  • the irradiation position control device 77 that has received the control command information from the irradiation control device 93 controls the excitation current supplied to each of the scanning electromagnets 30 and 31 based on the information on the irradiation position in the set layer, and the ions A deflection magnetic field is generated in each of the scanning electromagnets 30 and 31 so as to irradiate the target irradiation position with the beam.
  • the deflection magnetic field generated by the scanning electromagnet 30 aligns the ion beam irradiation position with the target irradiation position in the X direction, and the deflection magnetic field generated by the scanning electromagnet 31 sets the ion beam irradiation position as the target irradiation position in the Y direction. Match.
  • step S7 the irradiation position control device 77 sets the ion beam irradiation position, and then outputs an ion beam irradiation start signal to the extraction control device 67.
  • the extraction control device 67 closes the open / close switch 12, an ion beam is emitted from the synchrotron accelerator 3 to the beam path 16.
  • step S39 It is determined whether the irradiation dose at the irradiation position matches the target dose (step S39).
  • the irradiation dose to the target irradiation position is measured by the dose monitor 32.
  • the dose determination device 78 that has input the measured irradiation dose from the dose monitor 32 determines whether the measured irradiation dose has reached the target irradiation dose. When the measured irradiation dose does not match the target irradiation dose, the determination in step S37 is “No”, the measured irradiation dose matches the target irradiation dose, and the determination in step S37 is “Yes”. Each process of step S7 and step S37 is repeatedly performed until it becomes. When the determination in step S ⁇ b> 37 is “Yes”, the dose determination device 78 outputs a beam extraction stop signal to the extraction control device 67.
  • step S9 since the extraction control device 67 that has input the beam extraction stop signal opens the open / close switch 12, the extraction of the ion beam from the synchrotron accelerator 3 is stopped.
  • step S40 It is determined whether the irradiation of the ion beam into the set layer is completed (step S40).
  • the layer determination device 79 that has received the control command information from the irradiation control device 93 determines whether the irradiation of the ion beam into the set layer is completed.
  • step S38 determines whether the irradiation of the ion beam into the set layer is completed.
  • step S41 it is determined whether ion beam irradiation has been completed on all layers.
  • the layer determination device 79 determines whether the irradiation of the ion beam to all the layers has been completed. Since there remains a layer that has not been irradiated with the ion beam, the determination in step S41 is “No”, and steps S32 to S38, S7, S39, S9, S40, and S41 are sequentially executed again. Is done. At this time, in step S32, the layer at the second deepest position is set. The energy required for the ion beam applied to this layer is 219 MeV.
  • step S35 the excitation current supplied to each of the X-direction steering electromagnets and the Y-direction steering electromagnets of the steering electromagnets HH1 and HH2 is updated in step S29 for 219 MeV by the control of the steering electromagnet controller 69.
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are adjusted.
  • step S36 the exciting current supplied to each of the respective X-direction steering magnet and the Y direction steering magnets steering electromagnet GH1 and GH2 are exciting current is included in the rotation angle table 219MeV GH1 X, GH1 Y, GH2 X and it is adjusted to GH2 Y.
  • step S41 Since the determination in step S41 performed again is “No”, the energy of the ion beam is changed for each layer toward the shallowest layer until the determination in step S41 for the shallowest layer of the affected part becomes “Yes”. Steps S32 to S38, S7, S39, S9, S40 and S41 are repeatedly performed while decreasing by 1 MeV. When the determination in step S40 is “Yes”, the treatment of the affected area using the ion beam ends.
  • each beam position in the irradiation device 29 is measured by the beam position monitor PRM and SPM arranged in the irradiation device 29 that is not affected by the distortion of the building due to secular change, and these measured values are measured.
  • Excitation currents HH1 X , HH1 Y , HH2 of the X-direction steering electromagnets and Y-direction steering electromagnets of the steering electromagnets HH1 and HH2 positioned upstream of the joint portion 35 of the HEBT system 15 and the GABT system 20 using the beam position.
  • X and HH2 Y are calculated respectively. For this reason, the time required to adjust the beam trajectory after the start of treatment can be shortened.
  • the rotation position of the rotating gantry 26 is held at the reference rotation angle which is one rotation angle, and the beam position monitor PRM and SPM are used to adjust the inside of the irradiation device 29. Since each of the beam positions is measured and the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are calculated, the time required for adjusting the beam trajectory can be further shortened.
  • the particle beam therapy system 1 that includes the scanning electromagnets 30 and 31 and can scan the ion beam according to the shape of the affected area, ions are applied to each layer of the affected area divided into a plurality in the ion beam irradiation direction.
  • ions are applied to each layer of the affected area divided into a plurality in the ion beam irradiation direction.
  • beam trajectory adjustment after treatment must also be performed for each energy.
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are calculated using the beam positions measured by the beam position monitors PRM and SPM, the rotation angle of the rotary gantry 26 is not changed.
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y may be calculated for each energy of the ion beam, the time required for adjusting the beam trajectory after the start of treatment can be significantly shortened.
  • the X of each of the steering electromagnets GH1 and GH2 attached to the rotating gantry 26 by the method described in paragraphs 0093 to 0096 of Japanese Patent No. 4299269.
  • the rotating gantry 26 is rotated by a predetermined angle, and each beam position measured by the beam position monitor PRM and SPM is used for each predetermined angle. Therefore, their excitation current must be calculated.
  • the excitation currents HH1 X , HH1 Y , and HH2 of the steering electromagnets HH1 and HH2 that are located upstream of the joint portion 35 are used by using the beam positions measured by the beam position monitors PRM and SPM. Since X and HH2 Y are calculated, there is no need to rotate the rotating gantry 26 at a predetermined angle and calculate these excitation currents for each predetermined angle.
  • the excitation currents HH1 X and HH1 Y calculated in the adjustment of the beam trajectory after the start of the treatment are used.
  • HH2 X and HH2 Y by the steering electromagnet controller 69 of the accelerator / transport system controller 64, the X direction steering electromagnet of the steering electromagnet HH1, the Y direction steering electromagnet, and the X direction steering electromagnet of the steering electromagnet HH2 and
  • the excitation current supplied to each of the Y direction steering electromagnets is controlled.
  • the beam path 16 of the HEBT system 15 is deformed due to distortion of the building or the like, and the position of the center of the exit of the HEBT system 15 and the center of the entrance of the GABT system 20 (center of the entrance of the beam path 21) in the joint portion 35.
  • the ion beam emitted from the synchrotron accelerator 3 to the beam path 16 passes through the center of the entrance of the beam path 21 and corresponds to the energy of the emitted ion beam in the irradiation device 29.
  • the target beam positions PRM X , PRM Y , SPM X and SPM Y to be passed are passed.
  • the ion beam to the affected part is obtained. Can be accurately performed.
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y calculated in step S28 are updated according to the energy of the ion beam and stored in the memory 62. For this reason, the calculated excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are used in the treatment of the affected area by ion beam irradiation in a certain period after the beam trajectory is adjusted after the start of treatment.
  • the excitation current supplied to each of the steering electromagnets HH1 and HH2 can be controlled.
  • the excitation currents GH1 X , GH1 Y which are created during the adjustment of the beam trajectory performed during the trial operation of the particle beam irradiation system 1 and are stored in the memory 62 and included in the rotation angle table information for each energy, GH2 X and GH2 Y are used to adjust the respective excitation currents of the X direction steering electromagnets and the Y direction steering electromagnets of the steering electromagnets GH1 and GH2 attached to the rotating gantry 26 when the beam trajectory is adjusted after the start of treatment. can do.
  • the respective excitation currents of the steering electromagnets GH1 and GH2 are calculated for each set angle of the rotating gantry 26, and in order to calculate these, the setting of the rotating gantry 26 is performed. It becomes unnecessary to measure each beam position in the irradiation device 29 for each angle by the beam position monitor PRM and SPM, and the adjustment of the beam trajectory after the start of treatment is greatly simplified. Can be significantly shortened.
  • the excitation currents GH1 X , GH1 Y , GH2 X, and GH2 Y included in the rotation angle table information for each energy stored in the memory 62 are used when steering the affected area using the particle beam irradiation system 1. It can also be used to adjust the respective excitation currents of the electromagnets GH1 and GH2.
  • the excitation currents GH1 X , GH1 Y , GH2 X and GH2 Y included in the rotation angle table information for each energy stored in the memory 62 are stored.
  • the target beam position PRM X which is associated with the rotational angle table information for each energy stored in the memory 62 using the PRM Y, SPM X and SPM Y, corresponding to each energy, steering magnets HH1 and HH2 Since the respective excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are calculated, the beam trajectory can be adjusted with high accuracy after the start of treatment.
  • the particle beam irradiation system 1A of the present embodiment has a configuration in which the control system 59 of the particle beam irradiation system 1 of the first embodiment is replaced with a control system 59A.
  • Other configurations of the particle beam irradiation system 1A are the same as those of the particle beam irradiation system 1 of the first embodiment.
  • the control system 59A includes a central control device 60A having a CPU 61A and a memory 62, and an accelerator / transportation system control device 64A.
  • the configuration other than the central control device 60A and the accelerator / transportation system control device 64A is the same as that of the control system 59. is there.
  • the CPU 61A has a configuration in which the beam trajectory adjusting device 94 is replaced with the beam trajectory adjusting device 94A and the beam trajectory adjusting device 97 is replaced with the beam trajectory adjusting device 97A.
  • the beam trajectory adjustment device 94A has a configuration in which the trajectory adjustment control device 95 is replaced with the trajectory adjustment control device 95A in the beam trajectory adjustment device 94.
  • the beam trajectory adjustment device 97A uses the trajectory adjustment control device 98 in the trajectory adjustment control device 98.
  • the adjustment control device 98A is replaced (see FIG. 16).
  • the other configuration of the CPU 61A is the same as the CPU 61
  • the other configuration of the beam trajectory adjusting device 94A is the same as the beam trajectory adjusting device 94
  • the other configuration of the beam trajectory adjusting device 97A is the same as the beam trajectory adjusting device 97. is there.
  • the accelerator / transportation system control device 64A has a configuration in which an energy setting device 51 is added to the accelerator / transportation system control device 64 used in the first embodiment.
  • Other configurations of the accelerator / transport system controller 64A are the same as those of the accelerator / transport system controller 64.
  • the energy setting device 51 is connected to the trajectory adjustment control devices 95A and 97A, respectively.
  • a beam trajectory adjustment method in the particle beam irradiation system 1A of the present embodiment will be described with reference to FIGS.
  • a beam trajectory adjustment method in a trial operation period after the installation of the particle beam irradiation system 1A is completed will be described with reference to FIGS.
  • a third beam trajectory adjustment program showing a procedure including steps S1 to S26 shown in FIGS. 5 and 17 is stored in the memory 62.
  • the procedure executed by the track adjustment control device 95A is a procedure in which steps S25 and S26 are added to steps S1 to S24 shown in FIGS. 5 and 6 executed by the track adjustment control device 95 in the first embodiment.
  • the memory 62 includes a fourth beam showing a procedure including steps S23, S2, S4, S5, S27, S7, S8, S16, S25, S26, S10, S28 and S29 shown in FIG.
  • An orbit adjustment program is also stored.
  • the trajectory adjustment control device 95A stores the beam trajectory in the trial run period stored in the memory 62.
  • the third beam trajectory adjustment program for performing the adjustment is selected, and control command information is transmitted to each control included in each of the accelerator / transportation system control device 64A and the gantry control device 73 based on the procedure of the third beam trajectory adjustment program. Output to the device. For this reason, adjustment of the beam trajectory during the trial run is performed as follows.
  • step S2 ion beam energy setting
  • step S3 the synchrotron is operated by the energy setting device 51 to which control command information is input from the trajectory adjustment control device 95.
  • the energy of the ion beam emitted from the accelerator 3 is automatically set to a maximum of 250 MeV, for example.
  • step S3 the rotating gantry 26 is rotated to an arbitrary certain rotation angle (for example, 270 °).
  • the beam trajectory is adjusted in the GABT system during the trial run. This adjustment of the beam trajectory is performed by steps S13 to S17, S20, S21, S18, S19 and S22 to S25 (see FIG. 17).
  • step S13 rotation of the rotating gantry 26
  • step S14 excitation of the steering electromagnet
  • step S15 extraction of the ion beam
  • step S16 input of the beam position measured by the beam position monitors PRM and SPM
  • step S17 Ion beam extraction stop
  • step S13 the rotating gantry 26 is rotated so that the rotation angle becomes, for example, 0 °.
  • step S18 and S19 are implemented similarly to Example 1, and next, the process of step S20 (determination of a rotation angle) is implemented.
  • step S18 excitation currents GH1 X , GH1 Y , GH2 X and GH2 Y at an energy of 250 MeV and a rotation angle of 0 ° are obtained.
  • step S21 (setting of a new rotation angle) by the rotation angle setting device 52 is performed, and this new rotation angle is 0.5 °.
  • Set to Steps S13 to S20 are performed at the set new rotation angle.
  • the steps in steps S21 and S13 to S20 are performed in steps S21 and S13 at a new rotation angle of 360 ° while increasing the new rotation angle by 0.5 °. The process is repeated until the determination in S20 becomes “Yes”.
  • step S22 incrementation of the rotation angle table by the table creation device 96 is performed in the same manner as in the first embodiment, and information on the created rotation angle table for 250 MeV is stored in the memory 62. Stored in
  • step S22 After step S22 is completed, the steps S23, S15, S24 and S17 are performed in this order as in the first embodiment.
  • step S17 it is determined whether the adjustment of the beam trajectory has been completed over the entire energy range of the ion beam (step S25).
  • the energy determination device 71 that has received the control command information from the trajectory adjustment control device 95 determines whether the beam trajectory adjustment has been completed in the entire energy range of the ion beam. Since the steps S3 to S24 are completed for 250 MeV, the determination in step S25 is “No”. In the present embodiment, 150 MeV to 250 MeV is set as the entire energy range of the ion beam, and this energy range is stored in the memory 62.
  • New energy is set (step S26).
  • the energy setting device 51 sets 249 MeV as new energy.
  • Steps S13 to S21 are repeated until each step of Steps S3 to S12 and Step S20 are determined to be “Yes” while decreasing by 1 MeV within a range of 249 MeV to 150 MeV until the determination of Step S25 is “Yes”.
  • Each process of step S22, S23, S15, S24, S17, S25, and S26 after the determination of step S20 and “Yes” is repeated.
  • step S25 for 150 MeV the beam trajectory adjustment within the installation period in the particle beam irradiation system 1A of the present embodiment is completed.
  • the information of each rotation angle table created for each 1 MeV within the range of 150 MeV to 250 MeV is stored in the memory 62 with the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y at the corresponding energy, and the beam. They are stored in association with PRM X , PRM Y , SPM X, and SPM Y , which are target beam positions for orbit adjustment.
  • cancer treatment by the particle beam irradiation system 1A is started.
  • the adjustment of the beam trajectory performed when a certain period has elapsed since the start of the cancer treatment will be described with reference to FIG.
  • This beam trajectory adjustment is periodically performed as in the first embodiment.
  • the procedure of the fourth beam trajectory adjustment program shown in FIG. 18 executed by the trajectory adjustment control device 98A is the same as the procedure shown in FIG. S26 is added, and steps S10, S28, and S29 are performed when the determination in step S25 is “Yes”.
  • the trajectory adjustment control device 98A When the operator inputs the second trajectory adjustment start signal from the input device 100 to the trajectory adjustment control device 98A of the beam trajectory adjustment device 97A, the trajectory adjustment control device 98A stores the beam trajectory after the start of treatment stored in the memory 62.
  • the fourth beam trajectory adjustment program for performing the adjustment is selected, and control command information is sent to each of the accelerator / transportation system control device 64A and the gantry control device 73 based on the procedure of the fourth beam trajectory adjustment program (see FIG. 18). Output to each control device included in the.
  • steps S4, S5, S27, S7, S8, S16, S25 and S26 are repeated until the beam trajectory adjustment after the start of treatment is “Yes” in step S25, and the determination in step S25 is “ This is performed by carrying out the steps S10, S28, and S29 after “Yes”.
  • step S23 as described above, the rotating gantry 26 is rotated to the reference rotation angle of 270 ° by the rotation control device 74 that has received the control command information.
  • step S2 the energy of the ion beam is automatically set to 250 MeV by the energy setting device 51. While maintaining the state in which the rotating gantry 26 is rotated at 270 °, the above steps S4, S5, S27, S7, S8, S16, S25 and S26 are repeated until the determination in step S25 becomes “Yes”. Furthermore, each process of step S10, S28, and S29 after the determination of step S25 becomes “Yes” is implemented.
  • steps S4, S5, S27, S7, S8, and S16 are performed in this order, and then step 25 (energy determination) is performed.
  • step 26 setting of new energy
  • step 26 setting of new energy
  • step 26 is performed by the energy setting device 51 and 249 MeV is set as new energy. While decreasing this energy by 1 MeV within the range of 249 MeV to 150 MeV, the steps S4, S5, S27, S7, S8, S16, S25 and S26 are repeated until the determination in step S25 becomes “Yes”. It is.
  • step S25 the extraction of the ion beam is stopped (step S10), and in step S28, the excitation current HH1 X supplied to each of the steering electromagnets HH1 and HH2 by the excitation current calculator 70.
  • HH1 Y , HH2 X and HH2 Y are calculated for each 1 MeV within the range of 150 MeV to 250 MeV, as in the first embodiment.
  • step S29 excitation current update
  • the excitation current supplied to each of the steering electromagnets HH1 and HH2 calculated by the excitation current update device 99 for each 1 MeV in step S28 is used in the same manner as in the first embodiment.
  • the excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y for each energy stored in the memory 62 are updated.
  • This example can obtain each effect produced in Example 1.
  • each excitation current supplied to each of the steering electromagnets GH1 and GH2 for each energy is further shortened than the time required for adjusting the beam trajectory after the start of treatment in the first embodiment.
  • Example 3 A particle beam irradiation system of Example 3 which is another preferred embodiment of the present invention will be described below with reference to FIGS. 19 and 20.
  • Each of the particle beam irradiation systems 1 and 1A of the first and second embodiments uses the ion beam generator 2 including the synchrotron accelerator 3 as an ion beam generator, but the particle beam irradiation system 1B of the present embodiment uses an ion beam generator.
  • An ion beam generator 2A including a cyclotron accelerator 84 is used as the apparatus.
  • the particle beam irradiation system 1B includes an ion beam generator 2A, a HEBT system 15, a GABT system 20, a rotating gantry 26, an irradiation apparatus 29, and a control system 59B.
  • the configurations of the HEBT system 15, the GABT system 20, the rotating gantry 26, and the irradiation device 29 are the same as those in the particle beam irradiation system 1 of the first embodiment.
  • the ion beam generator 2A and the control system 59B different from the particle beam irradiation system 1 will be mainly described.
  • the ion beam generator 2A includes an ion source 83 and a cyclotron accelerator 84.
  • the cyclotron accelerator 84 includes a circular vacuum vessel 92, deflecting electromagnets 85A and 85B, a high-frequency accelerator 86, and an emission septum electromagnet 87.
  • the vacuum duct 46 connected to the ion source 83 extends to the center position of the vacuum vessel 92 and is connected to the vacuum vessel 92.
  • An incident electrode 91 that is curved in the horizontal plane is disposed in the vacuum container 92 near the open end of the vacuum duct 46.
  • the deflecting electromagnets 85A and 85B each have a semicircular shape, are arranged so that the straight portions face each other, and cover the upper and lower surfaces of the vacuum vessel 92.
  • a septum electromagnet 87 provided at the ion beam exit of the vacuum vessel 92 is connected to the beam path 16 of the HEBT system 15.
  • a degrader 88 having a plurality of metal plates is attached to the beam path 16 between the septum electromagnet 87 and the quadrupole electromagnet 18.
  • the degrader 88 has a function of adjusting the energy of the ion beam emitted from the cyclotron accelerator 84, and includes a plurality of metal plates (not shown) having different thicknesses. These metal plates are movable in a direction perpendicular to the beam path 16.
  • the attenuation of energy of the ion beam passing through the beam path 16 is controlled.
  • the energy of the ion beam irradiated to the affected part of the patient 34 can be changed, and each layer existing in the depth direction of the affected part can be irradiated with the ion beam.
  • the control system 59B includes a central controller 60, an accelerator / transport system controller 64B, a gantry controller 73, a scanning controller 76, and a database 81 (see FIG. 19).
  • the central control device 60 includes a CPU 61 including an irradiation control device 93, a beam trajectory adjusting device 94 and a beam trajectory adjusting device 98, and a memory 62 connected to the CPU 61.
  • the CPU 61 specifically has the configuration shown in FIG. 4B described in the first embodiment.
  • the gantry control device 73 and the scan control device 76 included in the control system 59B used in the particle beam irradiation system 1B are the gantry control device 73 and the scan control included in the control system 59 used in the particle beam irradiation system 1 of the first embodiment. It has the same configuration as the device 76.
  • the accelerator / transport system controller 64B included in the control system 59B has a configuration in which the high-frequency voltage controller 66 is replaced with a degrader controller 89 in the accelerator / transport system controller 64 included in the control system 59 used in the first embodiment. Have. Other configurations of the accelerator / transport system controller 64B are the same as those of the accelerator / transport system controller 64.
  • the irradiation control device 93 includes an electromagnet control device 65, an emission control device 67, a steering electromagnet control device 69, a memory 72, a degrader control device 89, a rotation control device 74, an irradiation position control device 77, a dose determination device 78, and a layer determination device 79. And the memory 80, respectively.
  • the trajectory adjustment control device 95 includes an electromagnet control device 65, an extraction control device 67, a beam position input device 68, a steering electromagnet control device 69, an energy determination device 71, a memory 72, a degrader control device 89, a rotation control device 74, and a rotation angle determination.
  • the device 75 and the rotation angle setting device 52 are respectively connected.
  • the trajectory adjustment control device 98 includes an electromagnet control device 65, an extraction control device 67, a beam position input device 68, a steering electromagnet control device 69, an energy determination device 71, a memory 72, a degrader control device 89, and a rotation control device 74, respectively. Connected. An irradiation position control device 77 is connected to the electromagnet control device 65, the emission control device 67, the steering electromagnet control device 69, and the degrader control device 89. The input device 100 is connected to the irradiation control device 93, the trajectory adjustment control device 95, and the trajectory adjustment control device 98 as in the first embodiment.
  • a beam trajectory adjustment method in the particle beam irradiation system 1B of the present embodiment will be described with reference to FIGS. 21, 6, and 22.
  • FIG. First a beam trajectory adjustment method in a trial operation period after the installation of the particle beam irradiation system 1B is completed will be described with reference to FIGS.
  • a fifth beam trajectory adjustment program showing a procedure including steps S1, S3, S4A, S5, S6, S43 and S8 to S24 shown in FIGS. 21 and 6 is stored in the memory 62. Further, the memory 62 also stores a sixth beam trajectory adjustment program showing a procedure including steps S23, S4A, S5, S27, S43, S8, S16, S10, S28 and S29 shown in FIG. ing.
  • the trajectory adjustment control device 95 When the operator inputs the first trajectory adjustment start signal from the input device 100 to the trajectory adjustment control device 95, the trajectory adjustment control device 95 performs the adjustment of the beam trajectory during the trial run, which is stored in the memory 62. A five-beam trajectory adjustment program is selected, and control command information is output to each control device included in each of the accelerator / transportation system control device 64A and the gantry control device 73 based on the procedure of the fifth beam trajectory adjustment program. For this reason, adjustment of the beam trajectory during the trial run is performed as follows.
  • step S1 the accelerator / transport system controller 64B starts the ion source and the linear accelerator.
  • step S2 the energy (for example, maximum 250 MeV) of the ion beam input from the input device 100 by the operator is set.
  • step S3 the rotating gantry 26 is rotated to an arbitrary certain rotation angle (for example, 270 °).
  • the electromagnet controller 65 that receives the control command information from the trajectory adjustment controller 95 controls the power supply 55A (see FIG. 20) and adjusts the excitation current supplied to the deflection electromagnets 85A and 85B and the septum electromagnet 87 of the cyclotron accelerator 84. (Step S4A).
  • step S5 excitation of deflection electromagnets and quadrupole electromagnets of HEBT system 15 and GABT system 20
  • step S6 excitation of steering electromagnets HH1, HH2, GH1, and GH2
  • the degrader is controlled based on the set energy (step S43).
  • the degrader control device 89 that has received the control command information from the trajectory adjustment control device 95 controls the drive device 90 to reduce the ion beam energy to a set energy (for example, 250 MeV). Are moved across the beam path 16.
  • steps S8 to S12 are performed.
  • the ion beam is extracted by the extraction controller 67 in step S8 by applying a voltage to the incident electrode 91 under the control of the extraction controller 67.
  • a voltage is applied to the incident electrode 91
  • the ions incident from the ion source 83 through the beam duct 46 into the vacuum container 92 are bent into the horizontal plane in the vacuum container 92 by the incident electrode 91 to which the voltage is applied, It is accelerated by a high frequency accelerator 86.
  • the extraction stop of the ion beam by the extraction control device 67 in step S10 is performed by stopping the application of the voltage to the incident electrode 91 under the control of the extraction control device 67.
  • Adjustment of the beam trajectory in the GABT system 20 within the trial operation period in the particle beam irradiation system 1B is repeated in the same manner as in the first embodiment until each step in steps S13 to S21 is “Yes” in step S20. Furthermore, when the determination in step S20 is “Yes”, the steps S22, S23, S15, S24, and S17 are performed in this order. As a result, adjustment of the beam trajectory in the GABT system 20 with respect to 250 MeV is completed, and rotation angle table information at 250 MeV is created.
  • rotation angle table information of 250 MeV, excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y and target beam positions PRM X , PRM Y , SPM X and SPM Y for beam trajectory adjustment at 250 MeV are associated with each other. And stored in the memory 62.
  • Step S2 the energy of the ion beam is input from the input device 100 in step S2 while decreasing by 1 MeV within a range of 249 MeV to 150 MeV, and steps S3, S4A, S5, S6, S43 and S8 to S24 are performed for each 1 MeV energy.
  • Steps S13 to S21 which are repeated until Step S20 becomes “Yes”, and Steps S22, S23, S15, S24 and S17 after Step S20 becomes “Yes” are repeated. To be implemented. Then, rotation angle table information is created for each energy.
  • rotation angle table information For each energy, rotation angle table information, excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y and target beam positions PRM X , PRM Y for beam trajectory adjustment, SPM X and SPM Y are stored in the memory 62 in association with each other.
  • Adjustment of the beam trajectory performed after the treatment of the affected area by irradiation of the ion beam to the affected area using the particle beam irradiation system 1B is described with reference to FIG.
  • the trajectory adjustment control device 97 performs the adjustment of the beam trajectory after the start of treatment stored in the memory 62.
  • Each of the control devices included in the accelerator / transport system control device 64B and the gantry control device 73 is selected based on the procedure of the sixth beam trajectory adjustment program (see FIG. 22). Etc. For this reason, the beam trajectory adjustment performed after the treatment is started by the particle beam irradiation system 1B is performed as follows.
  • the procedure shown in FIG. 22 performs the adjustment of the beam trajectory performed after the start of treatment by the particle beam irradiation system 1 of the first embodiment.
  • the steps S4 and S7 are performed.
  • the procedure is replaced with the steps S4A and S43.
  • step S1 activation of the ion source and the linear accelerator 14
  • steps S23 and S2 performed in the beam trajectory adjustment performed after the treatment is started in the first embodiment are sequentially performed.
  • the rotation angle of the rotating gantry 26 is maintained at a reference rotation angle (for example, 270 °) and the energy of the ion beam is maintained at 250 MeV
  • the aforementioned step 4A is performed, and steps S5 and S27 are performed in the first embodiment. It is carried out in the same way.
  • Step S43 control of the degrader described above is performed, and further, steps S8, S16, S10, S28, and S29 are performed.
  • Step S8 is performed by applying a voltage to the incident electrode 91
  • step S10 is performed by stopping the voltage application to the incident electrode 91.
  • Steps S16, S28, and S29 are performed in the same manner as in the first embodiment.
  • the energy of the ion beam is decreased by 1 MeV within a range of 249 MeV to 150 MeV, and the input device 100 in step S2.
  • the steps S4A, S5, S27, S43, S8, S16, S10, S28, and S29 are repeated for each 1 MeV energy.
  • excitation currents HH1 X , HH1 Y , HH2 X and HH2 Y are calculated with respect to the energy for each 1 MeV within the range of 250 MeV to 150 MeV, and stored in the memory 62 using these calculated excitation currents.
  • the exciting currents HH1 X , HH1 Y , HH2 X and HH2 Y are updated.
  • each effect produced in the first embodiment can be obtained.
  • Adjustment of the beam trajectory performed after the start of treatment in the particle beam irradiation system 1B is performed in FIG. 18 performed by adjusting the beam trajectory after the start of treatment in the particle beam irradiation system 1A, instead of the procedure shown in FIG.
  • the indicated procedure may be used.
  • Steps S4 and S7 shown in FIG. 18 become Steps S4A and S43 described above, and Steps 8 and S10 shown in FIG. 18 apply voltage to the incident electrode 91 by the emission control device 67. This is implemented by turning ON / OFF the.
  • Beam trajectory adjustment device 95, 95A, 98, 98A ... Trajectory adjustment control device, 96 ... Table preparation device, 99 ... Excitation current update device, HH1, HH2, GH1, GH2 ... Steering electromagnet, HP1, HP2, PRM, SPM ... Beam position monitor

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JP2024033101A (ja) * 2022-08-30 2024-03-13 株式会社東芝 放射線計測器支持装置、放射線計測装置および放射線計測方法

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JP2003282300A (ja) * 2002-03-26 2003-10-03 Hitachi Ltd 粒子線治療システム
JP4299269B2 (ja) * 2005-06-06 2009-07-22 株式会社日立製作所 粒子線治療システム
JP2011005096A (ja) * 2009-06-29 2011-01-13 Hitachi Ltd 粒子線照射制御装置

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JP4299269B2 (ja) * 2005-06-06 2009-07-22 株式会社日立製作所 粒子線治療システム
JP2011005096A (ja) * 2009-06-29 2011-01-13 Hitachi Ltd 粒子線照射制御装置

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* Cited by examiner, † Cited by third party
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WO2018207244A1 (ja) * 2017-05-09 2018-11-15 株式会社日立製作所 粒子線治療装置
TWI652090B (zh) 2017-05-09 2019-03-01 日商日立製作所股份有限公司 粒子線治療裝置

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