WO2016127463A1 - 一种保肝排毒降脂降糖药物及其应用 - Google Patents

一种保肝排毒降脂降糖药物及其应用 Download PDF

Info

Publication number
WO2016127463A1
WO2016127463A1 PCT/CN2015/073924 CN2015073924W WO2016127463A1 WO 2016127463 A1 WO2016127463 A1 WO 2016127463A1 CN 2015073924 W CN2015073924 W CN 2015073924W WO 2016127463 A1 WO2016127463 A1 WO 2016127463A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
liver
protecting
lowering
detoxifying
Prior art date
Application number
PCT/CN2015/073924
Other languages
English (en)
French (fr)
Inventor
赵浚宏
Original Assignee
赵浚宏
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 赵浚宏 filed Critical 赵浚宏
Priority to EP15722345.4A priority Critical patent/EP3078382A1/en
Publication of WO2016127463A1 publication Critical patent/WO2016127463A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Definitions

  • Hepatitis is inflammation of the liver. Many complications occur due to abnormal hematopoietic function, which seriously endangers the health of the people. Due to the variety of hepatitis, the cause of the disease is complicated. If it is not treated in time or the treatment effect is not good, the condition will gradually change. This shows that protecting the liver is still important. According to incomplete statistics, there are more than 100 million people infected with hepatitis B virus in China and 20 million patients with chronic hepatitis B. It is a veritable "hepatitis B big country”. More than 80% of the serious diseases such as liver cirrhosis and liver cancer in China are developed from hepatitis B.
  • the object of the present invention is to provide a liver-protecting, detoxifying, lipid-lowering and hypoglycemic agent and an application thereof, which can realize the rehabilitation of liver disease in the first and middle stages, lowering blood fat, lowering blood sugar, slimming and body shaping, and moistening the intestines.
  • the invention relates to a liver-protecting and detoxifying lipid-lowering and hypoglycemic agent, which comprises 10 to 35 parts of melon root, 5 to 20 parts of Sophora flavescens, 15 to 40 parts of tartary buckwheat, 5 to 25 parts of yam, 10 to 40 parts by weight.
  • liver-protecting, detoxifying, lipid-lowering and hypoglycemic drugs of the invention can be prepared by the traditional Chinese medicine processing method and the existing preparation process.
  • liver-protecting and detoxifying lipid-lowering and hypoglycemic medicament of the invention for preparing medicine for treating liver diseases.
  • the invention relates to the application of the liver-protecting and detoxifying lipid-lowering and hypoglycemic drugs for preparing medicines for treating blood lipids.
  • the invention relates to the application of the liver-protecting and detoxifying lipid-lowering and hypoglycemic drugs for preparing medicines for treating diabetes.
  • Soil melon root bitter, cold. Return to the liver, spleen, stomach.
  • the root of the melon is rich in fatty acids, including hawthorn, amino acids, carotene, and choline.
  • Pueraria cool, sweet, spicy. Indications of typhoid fever, headache (strong neck stiffness), annoying heat and thirst, diarrhea, measles impervious, high blood pressure, angina pectoris, deafness and other symptoms.
  • Pollen containing a large amount of nutrients and physiologically active substances such as starch, glucose, fructose, vitamins Biotin and enzymes. It can regulate the nervous system, promote sleep, enhance physical fitness; improve gastrointestinal function, promote digestion, enhance appetite, prevent habitual constipation; protect liver and protect liver, prevent anemia, diabetes, etc.; regulate endocrine and improve body function.
  • liver-protecting, detoxifying, lipid-lowering and hypoglycemic drugs of the invention the compatibility is reasonable, the dosage is within a reasonable range, and the toxicity is not.
  • the liver-protecting, detoxifying, lipid-lowering and hypoglycemic medicament of the invention utilizes the pharmacological effects of the soil melon root and the ginseng root to achieve the functions of clearing the liver and gallbladder, dampness and yellowing and treating chronic hepatitis; cooperating with the bitter and spleen qi and qi In addition to the wind, the spleen, appetizer, tonic, and the spleen of the yew root, hangover, toxic alcohol, pollen, thirst, clear yellow biliary.
  • the medicine of the invention has the functions of protecting liver, detoxifying, reducing fat and lowering blood sugar, and realizes the following functions: liver dysfunction, fatty liver, alcoholic liver, liver cirrhosis, hepatitis, liver ascites, and can also be used for constipation, has special curative effect, and constipation is continuously taken. Fifteen days can be cured. It can also be used for the treatment of toothache, and the special effect can be quickly relieved within a few hours; within three days, the loosening of the teeth will naturally restore and stabilize. It is used to lower blood sugar and urine sugar, and it can stop the injection of insulin within a few days. As long as the complications are cut off, most people can recover within 3-4 months.
  • the liver-protecting and detoxifying lipid-lowering and hypoglycemic agent of the first embodiment comprises, by weight, 15 parts of soil melon root, 15 parts of Sophora flavescens, 30 parts of tartary buckwheat, 15 parts of yam, 10 parts of pueraria, and 20 parts of pollen.
  • the liver-protecting and detoxifying lipid-lowering and hypoglycemic agent of the present invention of Example 1 is a capsule preparation, which can be prepared by the preparation method of the existing capsule preparation. Specifically, it can be carried out according to the following preparation method: each raw material is weighed according to the above-mentioned weight parts, separately extracted by alcohol, then ground into a powder form, and mixed to obtain a raw material mixture; and then a conventional raw material auxiliary or auxiliary ingredient is added to the raw material mixture. The drug mixture is obtained; and the drug mixture is then filled in a capsule.
  • liver-protecting, detoxifying, lipid-lowering and hypoglycemic drugs of the first embodiment in the preparation of a medicament for treating liver diseases.
  • the dosage is: 1 or 2 times a day, 1 capsule each time.
  • a liver-protecting, detoxifying, lipid-lowering and hypoglycemic agent according to the second embodiment comprises, by weight, 15 parts of soil melon root, 20 parts of Sophora flavescens, 30 parts of tartary buckwheat, 15 parts of yam, 10 parts of pueraria, and 20 parts of pollen.
  • a prepared tablet of the raw material comprises, by weight, 15 parts of soil melon root, 20 parts of Sophora flavescens, 30 parts of tartary buckwheat, 15 parts of yam, 10 parts of pueraria, and 20 parts of pollen.
  • the preparation method of the tablet preparation of the second embodiment is as follows: the raw materials are weighed according to the above weight parts, and the respective alcohols are respectively After being pulverized, it is ground into a powder and mixed to obtain a raw material mixture; and a medicinal conventional auxiliary or auxiliary component is added to the raw material mixture to obtain a drug mixture; and then the drug mixture is prepared according to a conventional tablet extrusion molding process. can.
  • Each tablet weighed 1 g and the effective amount (i.e., the amount of the raw material mixture) contained in each tablet was 0.35 g.
  • liver-protecting and detoxifying lipid-lowering and hypoglycemic drugs of the second embodiment in the preparation of a medicament for treating urine protein.
  • a liver-protecting, detoxifying, lipid-lowering and hypoglycemic agent according to the third embodiment comprises, by weight, 10 parts of soil melon root, 10 parts of Sophora flavescens, 20 parts of tartary buckwheat, 10 parts of yam, 40 parts of pueraria, and 10 parts of pollen.
  • the preparation method of the liver-protecting and detoxifying lipid-lowering and hypoglycemic agent of the third embodiment can be carried out by following the method described in Example 2, and then the drug mixture can be prepared according to the molding process of a conventional granule.
  • the weight of each granule preparation was controlled to be 5 g, and the effective amount (i.e., the amount of the raw material mixture) contained in each granule preparation was 0.5 g.
  • liver-protecting, detoxifying, lipid-lowering and hypoglycemic drugs of the third embodiment in the preparation of a medicament for treating diabetes.
  • the liver-protecting and detoxifying lipid-lowering and hypoglycemic agent of the fourth embodiment comprises, by weight, 10 parts of soil melon root powder, 5 parts of matrine, 30 parts of tartary buckwheat, 25 parts of yam, 10 parts of pueraria, and 25 parts of pollen. A decoction prepared from raw materials.
  • the preparation method is as follows: the raw materials are weighed according to the above-mentioned weight parts, extracted with water or organic solvent, and the obtained active ingredients are mixed, and then added to the medicinal conventional auxiliary materials or auxiliary ingredients (for example, honey) to obtain a decoction drug. It is controlled to contain 0.5 g of an effective pharmaceutical ingredient per 20 g of the decoction drug.
  • liver-protecting and detoxifying lipid-lowering and hypoglycemic drugs of the fourth embodiment in the preparation of a medicament for treating constipation.
  • the liver-protecting and detoxifying lipid-lowering and hypoglycemic agent of the embodiment 5 is composed of 10 parts of soil melon root, 5 parts of matrine, 40 parts of bitter, 5 parts of yam, 10 parts of pueraria and 30 parts of pollen by weight. Prepared powder.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

一种保肝排毒降脂降糖药物及其应用,该药物是由包括土瓜根10-35份、苦参5-20份、苦荞15-30份、山药15-25份、葛根10-35份、和花粉10-25份的原料制成的,所述药物可治疗肝病、血脂高和糖尿病。

Description

一种保肝排毒降脂降糖药物及其应用 技术领域
本发明涉及中药组合物技术领域,具体涉及一种保肝排毒降脂降糖药物及其应用。
背景技术
肝炎是肝脏的炎症,由于造血功能不正常而产生很多并发症,严重危害人民的身体健康。由于肝炎的种类繁多,致病的病因复杂,如未及时治疗或者治疗效果不佳,使病情会逐渐变化。由此可见,保护肝脏犹为重要。据不完全统计,我国现有乙肝病毒感染者1亿多人,有慢性乙肝病人2000万人,是名副其实的“乙肝大国”。我国现有的肝硬化、肝癌等严重疾病,80%以上都是由乙肝发展而来的。可见,如果研究证实了该药物的有效性,发展前景相当可观。目前,医学上对肝炎的治疗,尤其是乙肝的治疗,主要采用的是抗病毒治疗,由于抗病毒治疗有其明确的适应症及禁忌症,以及受经济条件等方面原因的影响,目前能够接收正规抗病毒治疗的患者还比较有限,所以大多数患者只能通过抗炎保肝来阻止疾病的进一步发展。
此外,血脂高、糖尿病等慢性病均成为威胁人们身体健康甚至生命的疾病,患病者大多需要吃药物来维持,但是由于该类药物的成本一般较高,给患病者带来很大的经济压力。
因此,亟待研发出一种适用性强、成本相对合理的治疗肝炎、血脂高、糖尿病等慢性病方面的药物。
发明内容
针对现有技术的上述缺陷和问题,本发明的目的是提供一种保肝排毒降脂降糖药物及其应用,能够实现康复肝病初、中期疾病,降血脂,降血糖,减肥塑身,润肠通便,利两便(大便和小便)的功能,且药物药源丰富,制备工艺简单。解决目前治疗肝炎、血脂高、糖尿病的药物价格高,而且疗效不佳的技术问题。
为了达到上述目的,本发明提供如下技术方案:
一种保肝排毒降脂降糖药物,按重量份,是由包括10~35份土瓜根、5~20份苦参、15~40份苦荞、5~25份山药、10~40份葛根和10~30份花粉的原料制备而成的制剂。
进一步地,按重量份,是由包括10~20份土瓜根、5~15份苦参、20~30份苦荞、15~20份山药、10~30份葛根和15~20份花粉的原料制备而成的制剂。
进一步地,按重量份,是由包括15份土瓜根、15份苦参、30份苦荞、15份山药、10份葛根和20份花粉的原料制备而成的制剂。
进一步地,按重量份,是由包括15份土瓜根、20份苦参、30份苦荞、15份山药、10份葛根和20份花粉的原料制备而成的制剂。
进一步地,按重量份,是由包括10份土瓜根、10份苦参、20份苦荞、15份山药、30份葛根和25份花粉的原料制备而成的制剂。
进一步地,按重量份,是由包括10份土瓜根、5份苦参、30份苦荞、25份山药、10份葛根和25份花粉的原料制备而成的制剂。
进一步地,所述制剂的剂型为医学上常用的口服制剂剂型。如,片剂、胶 囊剂、冲剂、颗粒剂或者散剂等。
本发明的保肝排毒降脂降糖药物采用传统的中药炮制方法和现有制备工艺制备即可。
本发明的保肝排毒降脂降糖药物用于制备治疗肝病药物中的应用。
本发明的保肝排毒降脂降糖药物用于制备治疗血脂高药物中的应用。
本发明的保肝排毒降脂降糖药物用于制备治疗糖尿病药物中的应用。
本发明的保肝排毒降脂降糖药物的配方的原理是:
土瓜根,苦、寒。归肝、脾、胃经。土瓜根含丰富脂肪酸,含山柰甙、氨基酸、胡萝卜素、胆碱等。可败毒抗癌、泻热祛淤、消肿止痛,痈疮肿毒。
苦参,味苦,性寒。肝;肾;大肠;小肠经;膀胱;心经;膀胱经。善降泄;具有清热燥湿利水退黄,祛风杀虫的功效。具有抗肿瘤作用,升白细胞作用,对心血管系统的作用,平喘祛痰作用,安定作用,抗过敏作用,免疫抑制作用等。
苦荞,据《本草纲目》记载,苦荞味苦,性平寒,能实肠胃,益气力,续精神,利耳目,炼五脏渣秽;在《千金要方》、《中药大辞典》及相关文献中对苦荞都有记载:可安神、活气血、降气宽肠、清热肿风痛、祛积化滞、清肠、润肠、通便、止咳、平喘、抗炎、抗过敏、强心、减肥、美容等功效。其为药食两用作物。
山药,味甘,性平。归脾、肺、肾经。补脾养胃,生津益肺,补肾涩精。
葛根,性凉,味甘、辛。主治伤寒温热、头痛项强(颈僵)、烦热消渴、泄泻、麻疹不透、高血压、心绞痛、耳聋等症。
花粉,含有大量的营养物质和生理活性物质,如淀粉、葡萄糖、果糖、维 生素和酶等。能够调节神经系统,促进睡眠,增强体质;改善肠胃功能,促进消化,增强食欲,防治习惯性便秘;保肝护肝,防治贫血、糖尿病等;调节内分泌,改善机体功能等。
本发明的保肝排毒降脂降糖药物中的配方中,配伍合理,使用量均在合理范围内,无毒性。本发明的保肝排毒降脂降糖药物利用土瓜根和苦参的药性药效,达到清肝利胆,燥湿退黄和治疗慢性肝炎的作用;配合以苦荞的健脾理气、祛风除痰,山药的健脾、开胃、补虚,以及葛根的清虚热、解酒毒,花粉的消渴、清黄胆。使得本发明的药物具有保肝排毒降脂降糖作用,实现如下功能:排肝毒、脂肪肝、酒精肝、肝硬化、肝炎、肝腹水,还可用于便秘,有特殊疗效,便秘者连续服用十五天可以根治。还可以用于牙痛的治疗,特效性在几个小时内能快速缓解;三日内达松动牙齿自然复位稳固康复。用于降血糖、尿糖,在几天内达到停用注射胰岛素,截止并发症,多数人在3-4个月内能达到康复。
本发明的保肝排毒降脂降糖药物的药物药源丰富,制剂制备采用现有常规工艺,技术操作简单,生产投资不大,具有较强的推广及应用价值,市场前景良好,发展空间巨大。
具体实施方式
下面将结合本发明的实施例,对本发明的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
本实施例1的一种保肝排毒降脂降糖药物,按重量份,是由包括15份土瓜根、15份苦参、30份苦荞、15份山药、10份葛根和20份花粉的原料制备而成的胶囊制剂。
实施例1的本发明的保肝排毒降脂降糖药物为胶囊制剂,采用现有的胶囊制剂的制备方法制备即可。具体地,可以按如下制备方法进行:按上述重量份称取各原料,分别醇提后再研磨成粉状,混合,得原料混合物;再向原料混合物中加入医药上常规用辅料或者辅助性成份,得药物混合物;再将药物混合物进行胶囊灌装即可。
将本实施例的保肝排毒降脂降糖药物灌装的胶囊采用0号胶囊,控制每个胶囊内的有效药量(即原料混合物的量)为0.38g。
本实施例1的保肝排毒降脂降糖药物在制备治疗肝病药物中的应用。
以下通过临床应用进一步证明本发明的药物在制备治疗肝病药物中的应用的有益效果。
服用量为:每日服用1~2次,每次1粒。
秦某,男,38岁,乙肝患者谷丙转氨酶服药前456,服药后16;谷草转氨酶服药前257,服药后26;服药期60天,检查结果显示肝功能恢复正常。
谢某,男,45岁,脂肪肝,酒精肝;连续服用本发明药物60天后均康复。
实施例2
本实施例2的一种保肝排毒降脂降糖药物,按重量份,是由包括15份土瓜根、20份苦参、30份苦荞、15份山药、10份葛根和20份花粉的原料制备而成的片剂。
本实施例2的片剂制剂的制备方法如下:按上述重量份称取各原料,分别醇 提后再研磨成粉状,混合,得原料混合物;再向原料混合物中加入医药上常规用辅料或者辅助性成份,得药物混合物;然后再将药物混合物按照常规片剂挤压成型制备工艺制备即可。每个片剂的重量为1g,每个片剂中含有的有效药量(即原料混合物的量)为0.35g。
本实施例2的保肝排毒降脂降糖药物在制备治疗尿蛋白药物中的应用。
以下通过临床应用进一步证明本发明的药物在制备治疗蛋白尿药物中的应用的有益效果。
服用方式:每天1~2次,每次一片(即1g)本实施例2的片剂药物。
龙某,男,15岁,患尿蛋白,服本药物前蛋白浓度pro=533.6,尿微量白蛋白,MAL361,服用本药物十天,复查各项指标恢复正常,停药后五个月复查,各项指标仍然正常。
实施例3
本实施例3的一种保肝排毒降脂降糖药物,按重量份,是由包括10份土瓜根、10份苦参、20份苦荞、10份山药、40份葛根和10份花粉的原料制备而成的颗粒制剂。
本实施例3的保肝排毒降脂降糖药物的制备方法按照实施例2中记载的方法得到药物混合物后,然后将药物混合物按照常规颗粒剂的成型工艺制备即可。控制每粒颗粒制剂的重量为5g,每粒颗粒制剂中含有的有效药量(即原料混合物的量)为0.5g。
本实施例3的保肝排毒降脂降糖药物在制备治疗糖尿病药物中的应用。
以下通过临床应用进一步证明本发明的药物在制备治疗糖尿病药物中的应用的有益效果。服用方式:每天1-2次,每次1粒(即5g)本实施例3的颗粒 制剂药物,服用60天。
刘某,男,44岁,患糖尿病5年,且流泪;脚软;头晕。服用本实施例药物五天后停用其它降糖药物,并继续连续服用本实施例药物十天后,并发症流泪、脚软、头晕明显减轻,继续连续服用2个月,空腹血糖在6.5-6.8之间。
杜某,男,76岁,患糖尿病,空腹血糖12.9,并伴有痛风,右腿痛麻,服用本实施例的药物三天后停止注射胰岛素,并继续连续服用本实施例药物十天后,并发症痛风未发,腿痛麻症状消失,连续服用30天,停用十日后,空腹检查,血糖7.6。
上述本发明的实施例1至实施例3中记载的“醇提”采用现有工艺即可。
实施例4
本实施例4的保肝排毒降脂降糖药物,按重量份,是由包括10份土瓜根粉、5份苦参、30份苦荞、25份山药、10份葛根和25份花粉的原料制备而成的汤剂。
制备方法如下:按上述重量份称取各原料,加水或者有机溶剂提取,提取所得的活性成分混合,再加入医药上常规用辅料或者辅助性成份(如,蜂蜜)即得汤剂药物。控制每20g汤剂药物中含有0.5g的有效药物成分。
本实施例4的保肝排毒降脂降糖药物在制备治疗便秘药物中的应用。
以下通过临床应用进一步证明本发明的药物在制备治疗便秘药物中的应用的有益效果。
服用方式:每天1-2次,每次20g本实施例4的汤剂药物,服用10天。
陈某,女,58岁,大便5天一次,还要靠化合物排便,服用本药物后次日排便2次,连续十五天,便秘症状消失,停药后保持了每天排便一次,睡眠质 量明显提高。
实施例5
本实施例5的保肝排毒降脂降糖药物,按重量成份,是由包括10份土瓜根,5份苦参,40份苦乔,5份山药,10份葛根和30份花粉的原料制备而成的散剂。
制备方法如下,按上述重量份称取各原料,分别研磨成粉状,混合后,将混合的原料混合物加工分为每小袋2g,即可。各原料采用块状或者颗粒状的原料即可。
以下通过临床应用进一步证明本发明的药物在制备治疗高血脂、塑身减肥的应用效果。服用方式,每天1-2次,每次一小袋(2g),服用期40天。
方某,男,45岁,身高160M,体重82.5KG,服用本药物40天后,体重67KG,且精力充沛,体力无损。血脂、血压体检正常。
本发明的保肝排毒降脂降糖药物除了上述的口服剂型外,还可以制备成丸剂及口服液等制剂。均采用传统的中药炮制方法制备即可。
本发明的关键在于该药物的配方计量恰当,才使得药物起到了特殊的功能药效作用。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应所述以权利要求的保护范围为准。

Claims (10)

  1. 一种保肝排毒降脂降糖药物,其特征在于:按重量份,是由包括10~35份土瓜根、5~20份苦参、15~40份苦荞、5~25份山药、10~40份葛根和10~30份花粉的原料制备而成的制剂。
  2. 根据权利要求1所述的一种保肝排毒降脂降糖药物,其特征在于:按重量份,是由包括10~20份土瓜根、5~15份苦参、20~30份苦荞、15~20份山药、10~30份葛根和15~20份花粉的原料制备而成的制剂。
  3. 根据权利要求1所述的一种保肝排毒降脂降糖药物,其特征在于:按重量份,是由包括15份土瓜根、15份苦参、30份苦荞、15份山药、10份葛根和20份花粉的原料制备而成的制剂。
  4. 根据权利要求1所述的一种保肝排毒降脂降糖药物,其特征在于:按重量份,是由包括15份土瓜根、20份苦参、30份苦荞、15份山药、10份葛根和20份花粉的原料制备而成的制剂。
  5. 根据权利要求1所述的一种保肝排毒降脂降糖药物,其特征在于:按重量份,是由包括10份土瓜根、10份苦参、20份苦荞、10份山药、40份葛根和10份花粉的原料制备而成的制剂。
  6. 根据权利要求1所述的一种保肝排毒降脂降糖药物,其特征在于:按重量份,是由包括10份土瓜根、5份苦参、30份苦荞、25份山药、10份葛根和25份花粉的原料制备而成的制剂。
  7. 根据权利要求1至6之一所述的一种保肝排毒降脂降糖药物,其特征在于:所述制剂的剂型为医学上常用的口服制剂剂型。
  8. 如权利要求1至6之一所述的一种保肝排毒降脂降糖药物用于制备治疗肝病药物中的应用。
  9. 如权利要求1至6之一所述的一种保肝排毒降脂降糖药物用于制备治疗血脂高药物中的应用。
  10. 如权利要求1至6之一所述的一种保肝排毒降脂降糖药物用于制备治疗糖尿病药物中的应用。
PCT/CN2015/073924 2015-02-12 2015-03-10 一种保肝排毒降脂降糖药物及其应用 WO2016127463A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15722345.4A EP3078382A1 (en) 2015-02-12 2015-03-10 Medicine for protecting the liver, removing toxins, reducing blood lipids and reducing blood sugar and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510075612.1A CN104623201B (zh) 2015-02-12 2015-02-12 一种保肝排毒降脂降糖药物及其应用
CN201510075612.1 2015-02-12

Publications (1)

Publication Number Publication Date
WO2016127463A1 true WO2016127463A1 (zh) 2016-08-18

Family

ID=53202763

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/073924 WO2016127463A1 (zh) 2015-02-12 2015-03-10 一种保肝排毒降脂降糖药物及其应用

Country Status (3)

Country Link
EP (1) EP3078382A1 (zh)
CN (1) CN104623201B (zh)
WO (1) WO2016127463A1 (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108686029A (zh) * 2018-08-20 2018-10-23 璐句寒 一种外用中药擦剂及其制备方法和应用
KR20200071492A (ko) 2018-12-11 2020-06-19 안동대학교 산학협력단 도토리 화분 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
KR20200071490A (ko) 2018-12-11 2020-06-19 안동대학교 산학협력단 다래 화분 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
KR20200097495A (ko) 2019-02-08 2020-08-19 재단법인 경북바이오산업연구원 송화분 에탄올 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105495608B (zh) * 2015-11-30 2018-06-19 河北康平健康产业有限责任公司 一种强化的食品添加剂及其制备方法
CN108785489A (zh) * 2018-08-30 2018-11-13 中国人民解放军火箭军总医院 一种预防和治疗电离辐射的药物组合物
CN112717115A (zh) * 2021-02-03 2021-04-30 杭州世子合德生物科技有限公司 一种中草药药剂及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264255A (zh) * 2008-04-25 2008-09-17 姜爱军 治疗糖尿病的中药组合物及其制备方法
CN101700341A (zh) * 2009-11-25 2010-05-05 江门市永才进出口有限公司 一种养肾护肝、排毒养颜生物组合物及其口服液的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1101238A (zh) * 1993-10-07 1995-04-12 西北师范大学应用科技研究所 苦荞系列保健食品-绿粒宝
CN1522583A (zh) * 2003-09-08 2004-08-25 太原市福乐清生物科技开发有限公司 苦荞茶
CN102396704A (zh) * 2010-09-13 2012-04-04 王卫华 一种高蛋白葛根降糖食品
CN102836408A (zh) * 2012-09-13 2012-12-26 赵淩宏 苦乔排毒粉及其制备方法
KR101651082B1 (ko) * 2012-12-31 2016-08-26 재단법인 전남생물산업진흥원 갈근엑스 발효물을 함유한 간손상 보호용 조성물
CN104225164A (zh) * 2014-10-09 2014-12-24 刘文正 一种治疗糖尿病的中药组合物及其制备方法与应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264255A (zh) * 2008-04-25 2008-09-17 姜爱军 治疗糖尿病的中药组合物及其制备方法
CN101700341A (zh) * 2009-11-25 2010-05-05 江门市永才进出口有限公司 一种养肾护肝、排毒养颜生物组合物及其口服液的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3078382A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108686029A (zh) * 2018-08-20 2018-10-23 璐句寒 一种外用中药擦剂及其制备方法和应用
KR20200071492A (ko) 2018-12-11 2020-06-19 안동대학교 산학협력단 도토리 화분 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
KR20200071490A (ko) 2018-12-11 2020-06-19 안동대학교 산학협력단 다래 화분 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
KR20200097495A (ko) 2019-02-08 2020-08-19 재단법인 경북바이오산업연구원 송화분 에탄올 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품

Also Published As

Publication number Publication date
CN104623201A (zh) 2015-05-20
EP3078382A4 (en) 2016-10-12
EP3078382A1 (en) 2016-10-12
CN104623201B (zh) 2018-09-25

Similar Documents

Publication Publication Date Title
WO2016127463A1 (zh) 一种保肝排毒降脂降糖药物及其应用
CN101933991B (zh) 一种镇痛抗炎药物及其制备方法
CN1530112A (zh) 一种抗肝纤维化的药物及其制备方法
CN1840166A (zh) 温胆汤现代中药口服制剂及其生产方法
CN110840966A (zh) 一种用于解酒的组合物及包含其的咀嚼片
CN105663966A (zh) 一种用于减肥瘦身、降脂的组合物
CN105999195B (zh) 一种参枝苓制剂的制备方法
CN108635551A (zh) 醒酒护肝中药组合物、制剂及制备方法和应用
CN107569528A (zh) 一种治疗肝炎的药物组合物、药物制剂及应用和制备方法
CN113577236A (zh) 一种用于保肝护胃醒酒的中药组合物、制剂及其制备方法
CN113058013A (zh) 一种中药组合物及其制备方法和应用
CN104510857B (zh) 一种用于降脂的中药有效部位组合物及其制剂
CN1686397A (zh) 具有益肝功能的保健食品
CN108704080B (zh) 一种治疗肾阴虚型抑郁症的药物及其制备方法
CN102225082A (zh) 一种防治糖尿病及其并发症的药物和其制备方法
CN106237205A (zh) 一种治疗哮喘的药物及其制备方法
KR20080005592A (ko) 급성 및 만성 기관지염의 치료용 약제의 제조에 있어서곤약 및 그 추출물의 용도
CN101352488B (zh) 一种用于湿热型黄疸性肝炎的药物组合物及其制备方法
CN101491581A (zh) 一种具有降血糖功能的组合物及其制备方法
CN112843209A (zh) 一种治疗慢性头晕的中药组合物及其应用
CN104473957B (zh) 一种用于降脂的中药单体组合物及其制剂
CN116637153A (zh) 一种具有抗慢性肾衰作用的中药组合物及其制备方法和应用
CN112717013A (zh) 柑橘幼果在制备改善胃肠道功能的药物中的用途
CN116391868A (zh) 一种养肝护肝药食同源组合物
CN1559503A (zh) 芒果止咳胶囊和长效胶囊的制备方法

Legal Events

Date Code Title Description
REEP Request for entry into the european phase

Ref document number: 2015722345

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2015722345

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15722345

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE