WO2016084462A1 - 自動分析装置 - Google Patents
自動分析装置 Download PDFInfo
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- WO2016084462A1 WO2016084462A1 PCT/JP2015/076601 JP2015076601W WO2016084462A1 WO 2016084462 A1 WO2016084462 A1 WO 2016084462A1 JP 2015076601 W JP2015076601 W JP 2015076601W WO 2016084462 A1 WO2016084462 A1 WO 2016084462A1
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- sample
- automatic analyzer
- rack
- analysis
- container
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00792—Type of components bearing the codes, other than sample carriers
- G01N2035/00801—Holders for sample carriers, e.g. trays, caroussel, racks
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00821—Identification of carriers, materials or components in automatic analysers nature of coded information
- G01N2035/00831—Identification of carriers, materials or components in automatic analysers nature of coded information identification of the sample, e.g. patient identity, place of sampling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00821—Identification of carriers, materials or components in automatic analysers nature of coded information
- G01N2035/00851—Identification of carriers, materials or components in automatic analysers nature of coded information process control parameters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
Definitions
- the present invention relates to an automatic analyzer for analyzing the amount of components contained in a specimen such as blood and urine, and more particularly to an automatic analyzer capable of measuring biochemical test items and blood coagulation test items.
- an analyzer that analyzes the amount of components contained in a sample, it measures the amount of transmitted or scattered light of single or multiple wavelengths obtained by irradiating light from a light source to a reaction mixture in which the sample and reagent are mixed.
- An automatic analyzer that calculates the amount of a component from the relationship between the amount of light and the concentration is known.
- Patent Document 1 a sample to be measured is put in a container such as a cup or a blood collection tube, and a plurality of these containers are simultaneously mounted on a sample mounting portion (hereinafter referred to as a rack), and this rack is placed on a sampler, and each sample is previously stored.
- An automatic analyzer is disclosed in which a sample is dispensed from a rack into a reaction tube according to registered measurement items, and analysis is performed according to each measurement item.
- a circular sampler can be equipped with several circular racks on which about 30 to 100 containers can be installed.
- a box-type rack on which 5 to 10 containers can be installed can be mounted in units of 10 racks using a tray.
- the circular sampler is configured so that the circular rack can be attached and detached.
- These replaceable circular racks are managed by numbers 1 to 9, and the numbers are attached as bar code seals.
- a technique for optically reading code information by a rack information detection unit and identifying individual racks by a control unit is also described.
- an object of the present invention is to provide an automatic analyzer that can efficiently perform a plurality of analyzes while reducing the footprint and cost of the device.
- the apparatus includes a container for storing a sample, one rack for placing a plurality of the containers, and a control unit, and the control unit is configured with respect to the one rack. Creating a plurality of registration patterns that associate the information on the position where the container is installed and the information on the sample contained in the container, storing the plurality of registration patterns created, and storing the plurality of registrations An automatic analyzer characterized by applying one selected registration pattern among the patterns to the one rack and analyzing the sample, and an analysis method using the apparatus are provided.
- an automatic analyzer capable of efficiently performing a plurality of analyzes while reducing the footprint and cost of the device, and an analysis method using the device.
- 5 is a flowchart showing basic operations from creation to analysis of a sample rack registration pattern in the automatic analyzer according to the present embodiment (first embodiment). It is a flowchart which shows in detail the basic operation
- FIG. 1 is a diagram schematically showing a basic configuration of an automatic analyzer according to the present embodiment.
- an automatic analyzer 100 mainly includes a sample dispensing probe (sample dispensing mechanism) 101, a sample rack 102, a reagent dispensing probe (reagent dispensing mechanism) 106, a reagent rack 107, a reaction container stock unit 111, The reaction container carrying / conveying mechanism 112, the detection unit 113, the reaction container discarding unit 117, the operation unit 118, the storage unit 119, and the control unit 120 are included.
- the sample dispensing probe 101 is accommodated in a sample (sample) accommodated in a sample container (sample container) 103 disposed in a sample rack 102 that rotates clockwise and counterclockwise, or in a quality control sample container (not shown).
- the quality control sample is sucked and discharged to the reaction vessel 104.
- the sample dispensing probe 101 is connected to the sample syringe pump 105, and is controlled by a computer that is the control unit 120 to execute sample aspirating and discharging operations.
- the reagent dispensing probe 106 aspirates the reagent contained in the reagent container 108 arranged in the reagent rack 107 and discharges it to the reaction container 104 containing the specimen.
- the mixed solution of the sample (including the diluted solution of the sample) and the reagent is referred to as a reaction solution.
- the reagent dispensing probe 106 is connected to the reagent syringe pump 110, and is controlled by a computer that is the control unit 120 to execute reagent aspirating and discharging operations.
- a reagent temperature raising mechanism 109 can be incorporated in the reagent dispensing probe 106.
- the control unit 120 controls the reagent temperature raising mechanism 109, the temperature of the reagent sucked by the reagent dispensing probe 106 is raised and adjusted to an appropriate temperature (predetermined temperature).
- the reaction container transport mechanism 112 transports and installs the reaction container 104.
- the reaction container conveyance mechanism 112 conveys and installs the reaction container 104 from the reaction container stock unit 111 to the reaction container installation unit 114 of the detection unit 113 by holding the reaction container 104 and rotating in the horizontal direction.
- the detection unit 113 includes one or more reaction container installation parts 114 (in this embodiment, one case is shown as an example) for placing the reaction container 104, and the reaction container installation part The light intensity of the reaction vessel 104 inserted into 114 is measured.
- the case where one detection unit 113 is arranged is shown, but the present invention is not limited to this, and a plurality of detection units 113 may be provided.
- the light source 115 of the detection unit 113 irradiates the reaction vessel 104 with light.
- the light emitted from the light source 115 is attenuated and transmitted by the reaction solution accommodated in the reaction vessel 104 or scattered.
- the detection unit (light sensor) 116 includes a photodiode or the like.
- the detection unit 116 receives transmitted light attenuated and transmitted by the reaction solution in the reaction vessel 104 or scattered scattered light, and performs light / current conversion, thereby converting a photometric signal indicating the received light intensity into A / A.
- the data is output to the D converter 121.
- a measurement signal of transmitted light or scattered light A / D converted by the A / D converter 121 is input to the control unit 120 via the interface 122.
- the operation of the detection unit 113 is controlled by a computer that is the control unit 120.
- the reaction container transport mechanism 112 holds the reaction container 104 for which measurement has been completed, transports it to the reaction container disposal unit 117, and discards it.
- the analysis items of the sample analyzed by the automatic analyzer 100 are input from the operation unit 118 to the control unit 120 via the operation screen displayed on the keyboard 118b or the display unit 118c as input means.
- a GUI Graphic User Interface
- inputs an analysis item by operating the analysis item displayed on the display unit 118c with a pointer or the like using the mouse 118a may be used.
- the control unit 120 mainly includes an overall control unit 120a, a measurement control unit 120b, and the like.
- the overall control unit 120a controls operations of the automatic analyzer 100 such as the above-described dispensing of samples and reagents, transfer of the reaction vessel 104, and disposal of the reaction vessel 104.
- the measurement control unit 120b calculates the measurement value of the light intensity that changes with time according to the degree of the mixing reaction between the sample and the reagent, and based on the calibration value acquired in advance, the concentration of the analyte or the reaction time (In the blood coagulation field, this refers to the clotting time, etc.). Moreover, based on the comparison result with a predetermined determination threshold value, it is also possible to determine the quality by determining the concentration and reaction time of the analyte contained in the sample.
- the calculated concentration or reaction time is output to the display unit 118c and stored in the storage unit 119.
- the concentration or reaction time as the calculation result may be printed out to the printer 123 via the interface 122.
- FIG. 2 is a diagram schematically showing a basic configuration of the sample rack 102 according to the present embodiment.
- FIG. 2 the installation positions for installing the sample containers 103 are numbered sequentially from position 1 as position information, and the installation position 1 (10), the installation position 2 (11), and the installation position 3 (12) are indicated. It is shown as a representative position.
- This figure shows a configuration in which the sample rack 102 has 20 installation positions on both the inner periphery and the outer periphery.
- FIG. 11 is a flowchart showing basic operations from creation to analysis of a sample rack registration pattern in the automatic analyzer according to the present embodiment.
- the registered pattern refers to information in which information related to the installation position of the sample container 103 in the sample rack 102 is associated with information related to the sample stored in the sample container 103 and the like.
- a registration pattern and detailed items are created for the sample rack 102 (S1101).
- the detailed item means, for example, an individual item in each process executed in the analysis such as QC or calibration.
- QC processing is classified in more detail according to its contents, such as QC-A, QC-B,.
- either the registration pattern or the detailed item may be created first, and can be applied to change according to the analysis and various situations.
- a plurality of registered patterns can be created such as registered patterns 1, 2, 3,.
- a method of creating a plurality of registered patterns and selecting them according to the analysis will be described, but it is also possible to create only a single registered pattern.
- step 1102 the detailed items created in step 1101 are assigned so as to be associated with each installation position determined by the registration pattern (S1102).
- step 1103 a registration pattern to be used for analysis is selected from the registration patterns to which detailed items are assigned in step 1102 (S1103).
- step 1104 the requested analysis content is captured or input (S1104).
- the contents of analysis include biochemical analysis and blood coagulation test.
- step 1105 necessary consumables such as specimens, samples, and various containers are installed in the automatic analyzer based on the analysis content captured or input in step 1104 (S1105).
- the installation may be performed by the operator by causing the control unit 120 to display an instruction to the operator on the display unit 118c, or the apparatus may be automatically performed by a sample container moving mechanism or the like. .
- FIG. 12 is a flowchart showing in more detail the basic operation of the automatic analyzer according to the present embodiment.
- Each operation shown in FIG. 11 will be described in detail with reference to FIG.
- the symbols A to G attached to the respective operations shown in FIG. 11 correspond to the symbols a to g shown in the drawing, respectively.
- the operation indicated by the symbol A in FIG. 11 includes the symbols a1 to a3 in FIG. 12 in more detail.
- step 1201 the number of the registered pattern to be created is selected (S1201). For example, when it is necessary to create six registration patterns, it is selected which of the numbers 1 to 6 is to be created.
- the sections are classified (S1202).
- the section refers to an area from a start number position to an end number position where, for example, a quality control sample, a calibrator, and various types of samples are arranged at a plurality of installation positions in the sample rack.
- step 1203 it is determined whether or not all necessary registration patterns have been created (S1203). If not, the processes in and after step 1201 are executed for the remaining registration patterns. On the other hand, if all necessary registration patterns have been created, the process advances to step 1206 together with the completion of steps 1204 and 1205.
- step 1204 the detailed items described above are created (S1204).
- step 1205 all the detailed items are created, and it is determined whether registration in the list is completed (S1205). If not completed, the remaining detailed items are also created in step 1204. . On the other hand, if registration in the list has been completed, the process proceeds to step 1206.
- step 1206 starts.
- a registration pattern to which the created detailed item is to be assigned is selected (S1206). For example, when six registration patterns are created, it is selected which of the registration patterns of numbers 1 to 6 is to be assigned detailed items.
- step 1207 the section classified in step 1202 corresponding to the target type of sample or the like is selected (S1207), and in step 1208, detailed items are assigned to the selected section in units of installation positions. (S1208).
- step 1209 it is determined whether or not all necessary assignments have been completed (S1209). If not, step 1207 is executed again.
- step 1206 If all the necessary assignments have been completed for the registered pattern selected in step 1206, it is determined whether or not all necessary registration patterns have been assigned (S1210). If not completed, the process returns to step 1203, and the remaining registered patterns that need to be allocated are selected and the same processing is performed.
- step 1211 the analysis content is requested in step 1211 (S1211).
- step 1212 the necessary registration pattern corresponding to the analysis content is obtained. It is determined whether it is selected (S1212).
- the necessary registration pattern is selected, the analysis content requested in step 1213 is taken in or input (S1213).
- the registration pattern is changed to a necessary one in step 1214 (S1214), and the requested analysis content is taken in or input in step 1215 (S1215).
- step 1216 Thereafter, the operator is instructed to install a sample or the like according to the analysis content requested in step 1216, or is automatically installed as described above (S1216).
- the analysis is executed in step 1217.
- step 1218 the analysis result obtained in step 1218 is output (S1218).
- FIG. 13 shows a modification of the flowchart shown in FIG. Steps 1301 to 1311 and steps 1317 to 1318 are the same as steps 1201 to 1211 and steps 1217 to 1218 shown in FIG.
- step 1312 the operator is instructed to install a sample or the like according to the analysis content requested in step 1311 (S1312).
- step 1313 it is next determined in step 1313 whether or not a necessary registration pattern has been selected (S1313). If selected, the analysis content requested in step 1314 is captured or input. (S1314). On the other hand, if it is not selected, the registration pattern is changed to a necessary one in step 1315 (S1315), and the requested analysis content is taken in or input in step 1316 (S1316).
- FIGS. 12 and 13 are diagrams schematically showing the display unit 118c according to the present embodiment.
- FIG. 3A is a diagram for explaining creation of a registered pattern on the display unit according to the present embodiment.
- 3A shows an example in which the display unit 118c selects and displays five types of registered patterns of sample information from registered pattern 1 to registered pattern 5 on the registered pattern display unit 301.
- FIG. As the sample information, at least the number of the installation position of the sample rack 102 and the type of the sample assigned thereto are registered, and these are displayed on the sample information display unit 302.
- the installation positions of the sample rack 102 are provided from No. 1 to No. 110, the installation positions of the quality control sample, the calibrator, various samples, and the cleaning liquid are divided by the installation position start number and end number. And register.
- the registered pattern display unit 301 and the sample information display unit 302 that displays information such as the sample related to the selected registered pattern can always be displayed during the analysis operation.
- FIG. 3B is a diagram for explaining another example of creating a registration pattern on the display unit according to the present embodiment.
- the apparatus inputs the registration number of specimens such as quality control samples and calibrators in the specimen information display unit 302 so that the apparatus The start number and the end number can be automatically assigned according to the order.
- a registration pattern suitable for a situation where calibration of analysis performance is mainly performed in a series of inspection work cycles is shown, and the identification name of the first registration pattern is used. It is registered under the name “Calibration 1” in a certain “Registration Pattern 1”.
- the identification name of the registered pattern is displayed on the identification name display unit 308. Instead of the identification name of the registered pattern, an identification number such as “1” or “2” may be used.
- the registered pattern and identification name can be arbitrarily created, deleted, determined, and selected by the operator.
- quality control samples can be installed at installation positions No. 1 to 20, and calibrators can be installed at installation positions No. 21 to 80.
- Samples are general samples, re-examination samples for which the effectiveness of re-examination is recognized for some reason as a result of the first inspection, and emergency tests are required.
- both the general sample and the retest sample can be installed in the same section of the installation positions Nos. 81 to 90.
- specimens such as factor-deficient plasma and coagulation dilution used for blood coagulation tests can be installed at installation positions No. 91 to 97.
- a cleaning solution used for cleaning the sample dispensing probe can be installed at installation positions No. 98 to 100.
- the detailed information is registered in each classification.
- the quality control sample installation positions Nos. 1 to 20 the quality control sample types are assigned to Nos. 1, 2, 3 to 20 and the identification information of the quality control sample is registered at each position. can do.
- the assignment of the calibrator type and the identification information can be registered for each installation position.
- identification information such as a sample number associated with analysis information such as patient information and analysis items is input. Can do.
- the detailed item display unit 303 can set and display more detailed items as described above for the large classification.
- FIG. 3C is a diagram illustrating assignment of detailed items on the display unit according to the present embodiment.
- a quality control sample (displayed as a control or QC in the figure) is registered in advance in a list shown in the registration list display section 304 shown on the left side in the figure, and prepared in a table format on the right side in the figure.
- the target for which the detailed item is to be set can be selected by the detailed item setting target display unit 307.
- the operator registers detailed identification information in order to place a sample etc. at a position that does not match the set section, and the device according to the identification information Asks the operator whether the parcel can be modified and can automatically change the parcel if they agree.
- the installation position between the newly registered installation position and the already registered section is also of the same type. Can be re-registered at once. For example, when the installation position of the quality control sample is No. 1 to 10 and the installation position of the calibrator is partitioned into No. 11 to 20, a new calibration letter is registered at the No. 5 installation position.
- the section is updated to a calibrator that is a matching section, or between No. 11 that is the currently registered section. Nos. 6, 7, 8, 9, and 10 that follow are updated to the calibrator section.
- the individual detailed identification information capable of storing the detailed information is secured in a common storage area, and can be freely registered and deleted by calling each registration pattern freely. Individual data that is deleted from the settings and screen when the section is changed on the registration pattern can be called from the common area and registered by calling it at another setting position or another registration pattern. .
- the device determines necessary samples according to this detailed information and automatically inputs classifications such as calibrators and general samples.
- the individual calibration results and quality control results are linked to the number and name of the detailed information, and when the selection is made using the mouse 118a, a transition is made to another display screen (not shown), and the operator results. Can be confirmed.
- Urgent specimens need to be preferentially analyzed regardless of when they are brought into the laboratory. This is because the operator always ensures a fixed position regardless of the registered pattern of the specimen rack 102. Can easily grasp the installation position and reliably install the specimen container 103 for the emergency specimen.
- a shortcut button (not shown, hereinafter referred to as a STAT button) for analyzing this urgent sample can be provided on the apparatus.
- STAT button for analyzing this urgent sample.
- the analysis can be continued for the sample that has already been dispensed.
- the installation positions No. 101 to 110 to which the emergency sample is assigned on the sample rack 102 move to the front of the apparatus, and the operator can install the emergency sample. Subsequently, when the operator instructs the apparatus to start analysis, the apparatus preferentially analyzes the installed emergency sample and outputs the result.
- the specimen information may be automatically input to the automatic analyzer through identification information such as a barcode attached to the specimen container 103 and an identification information reading apparatus such as an optical barcode reader.
- identification information such as a barcode attached to the specimen container 103 and an identification information reading apparatus such as an optical barcode reader.
- a description can be added to the display unit 118c via the mouse 118a and the keyboard 118b.
- FIG. 4 is a diagram for explaining still another example of creating a registration pattern or the like on the display unit according to the present embodiment.
- the application button 406 displayed on the screen displayed on the display unit 118c is selected by the input unit such as the mouse 118a, the corresponding registration pattern is applied to the apparatus.
- a hardware switch corresponding to a registered pattern of a sample or the like can be provided as an independent button for numbers 1 to 5 on the apparatus (not shown). According to this, the operator can apply a desired registration pattern to the apparatus via the input unit such as the keyboard 118b or the mouse 118c of the operation unit 118, and the desired registration pattern is linked as another means. The registered pattern can be applied to the apparatus by depressing the hardware switch.
- a device display unit that displays all or one of the name, identification number, description, and content of the registered pattern can be provided instead of the indicator lamp indicating the applied registered pattern (not shown).
- the apparatus instructs the operator to set the sample or the like by displaying on the display unit 118c.
- the operator installs a sample or the like at the installation position of the sample container 103 in the sample rack 102 according to the contents of the applied registration pattern.
- the device can be automatically installed as described above.
- the operator gives an instruction to start analysis to the automatic analyzer via the operation unit 118.
- the automatic analyzer performs a positioning operation such as rotation of the sample rack 102 and stops so that the sample container 103 containing the sample scheduled in advance is positioned at the sample aspirating position of the sample dispensing probe 101. Let Thereafter, the automatic analyzer sequentially performs aspiration of the specimen and the subsequent analysis operation.
- the timing when the operator can apply the registration pattern to the device will be explained.
- Automatic analyzers can be broadly classified into three device states.
- the first state is an analysis standby state, which is a step for the operator to make preparations before starting the analysis. This is a step in which registration and installation of samples and reagents used for analysis, registration of analysis requests, replenishment of consumables for the apparatus, and the like are completed. Both confirmation, change, and application of the registration pattern of the sample rack 102 are possible.
- this state it can be said that the operator can easily recognize the state of the apparatus more easily because it is easy to obtain a match between the specimen and the like installed in the apparatus and the information such as the sample registered in the apparatus.
- the second state is an analysis operation state.
- the apparatus processes the requested analysis according to the schedule.
- the installed samples and the like are processed sequentially or in batches, and after the analysis time required for the requested analysis item has elapsed, the results are output to the display unit 118c sequentially from the sample or the like from which the analysis results were obtained. .
- FIG. 6 is a diagram for explaining application / input / confirmation of a registered pattern on the display unit according to the present embodiment.
- the status display section 609 of the display section 118c in the “status” frame, “analyzing” that is the current apparatus status and the identification name of the registered pattern that is used for the analysis that is in the middle of this processing are displayed.
- Registration pattern 2 "is displayed.
- the registered pattern “registered pattern 2” linked to the “under analysis” state is selected by selecting the tab of the marker name with the mouse 118a. Restrictions are set so that they can be confirmed but cannot be changed.
- “registration pattern 1”, “registration pattern 3”, “registration pattern 4”, and “registration pattern 5” exemplified as other identification names select the tab of the label name with the mouse 118a, so that the registered contents are displayed. It can be confirmed and changed.
- the operator does not misidentify the registration pattern applied in the current analysis and the registration pattern scheduled to be applied in the next analysis, and even if the device is in analysis operation, It is possible to input and set a registration pattern to be applied in step 1, and to use the apparatus efficiently.
- a link is set on the screen so that the screen for confirming and setting the registered pattern can be easily transitioned to a screen showing the analysis result and a screen showing the device status.
- the analysis result display button 610 of the display unit 118c is selected with the mouse 118a, the obtained analysis result and the state of the apparatus are displayed.
- a link is set so that the transition can be made easily.
- a schedule function can be provided to handle a wider variety of samples.
- FIG. 7 is a diagram for explaining switching, application / input / confirmation, and the like of a plurality of registered patterns on the display unit according to the present embodiment.
- the status display section 709 of the display section 118c in the “status” frame, “analyzing” that is the current apparatus status and the identification name of the registered pattern used for the analysis that is in the middle of this processing are displayed.
- a registered pattern 2 ”and a number“ 1 ”which is a schedule order in a schedule display section 711 described later are displayed.
- the schedule display section 711 the schedule of the registered pattern is shown, and the processing order and the rack number corresponding to this order are displayed.
- the operator can display the contents of the registered pattern by selecting display of the schedule number or the sign name with the mouse 118a in order to confirm the contents of the scheduled registered pattern.
- registered patterns required to analyze them are searched and inquired for each analysis item, and the registered pattern in which the corresponding specimen is set and its installation position are linked, and the schedule is It is determined.
- the scheduled order may be determined manually by the operator or automatically by the device.
- a transfer mechanism for automatically installing the sample container 103 on the sample rack 102 can be provided.
- the analysis result display button 710 when the analysis result display button 710 is selected with the mouse 118a, the obtained analysis result and the state of the apparatus can be displayed, and it is also easy to return to the original screen. .
- the following structure can be applied as a means for the operator to recognize the state of the device and the applied registration pattern in an easy-to-understand manner. Even if the color tone of the screen is changed to clearly indicate whether the registered pattern displayed on the display unit 118c is a registered pattern being analyzed or a registered pattern to be applied in the subsequent analysis. Good. Further, the screen may be divided into left and right, top and bottom, etc., the registered pattern being analyzed may be displayed on the left or upper side, and the registered pattern to be applied in the subsequent analysis may be displayed on the right or lower side. It is clear that the above-described structure is not necessarily mounted at the same time, and the effect can be obtained by appropriately selecting and combining them. As a result, continuous analysis of a large number and many types of specimens can be performed.
- the third state is a return operation state to the standby state.
- the apparatus finishes the requested analysis, and the analysis results are sequentially output.
- the apparatus state is initialized such as cleaning or disposal of the reaction vessel 104 and returning to the standby position of each machine. Yes.
- the sample container 103 can be newly installed in the apparatus, and a new analysis request can be made. Therefore, it is possible to confirm, change, and apply the registered contents.
- the analysis result is in the middle of output, it is possible to restrict the change of the contents of the corresponding registered pattern and the application of a registered pattern different from this.
- the operator can instruct the apparatus to start analysis after placing the sample or the like in the sample rack 102 and registering the analysis request item.
- FIG. 15 is a diagram for explaining confirmation of a registration pattern on the display unit according to the present embodiment.
- a registration pattern information display section is displayed on a screen for displaying a start button 1509 for instructing the analysis start so that the operator can finally confirm the analysis request item and the applied registration pattern at the start of the analysis.
- a registration pattern (shown as a rack number in the figure), registration contents at each installation position, and detailed information are displayed.
- the display method of the start button 1509 and the registered pattern information display unit 1510 can be displayed all on the same screen, or can be switched sequentially. Further, as shown in FIG. 15, it can be visualized by color coding or the like so that the classification of each section of the registered pattern can be easily confirmed.
- the automatic analysis apparatus can be added with a function for automating the registration pattern setting by a timer or by using an operation as a trigger when the apparatus is turned on.
- the types of specimens used are expected to vary depending on the date, day of the week, and season. For example, when a sample to be used on each day of the week is approximately fixed, a function of automatically selecting and setting a registered pattern of the sample rack 102 corresponding to the content depending on the day of the week when the apparatus is turned on By providing this, more efficient operation can be achieved. For example, in the morning of Monday, when the status of devices, specimens, reagents, etc. is often checked, a registration pattern with an increased number of calibrator installation positions is created in advance in order to perform many calibrations. Can be applied. A large number of general specimens are brought in.
- a registration pattern in which the installation positions of general specimens are increased is created in advance, and this can be automatically applied.
- a registered pattern with an increased number of installation positions of the quality control sample must be created in advance and applied automatically. Can do.
- a registration pattern in which the installation positions of the calibrator and the quality control sample are increased is created in advance, and this can be automatically applied. According to this, it is possible to save time for setting the apparatus.
- a plurality of sample racks 102 can be provided.
- a registration pattern can be input, confirmed, and applied for each sample rack 102. By doing so, it is possible to analyze a larger number of samples.
- an automatic analyzer that creates a registered pattern in which analysis methods such as biochemical analysis and blood coagulation analysis are used alone or mixed is described.
- an example of an automatic analyzer that uses a registered pattern in which the positions of specimens and the like are divided for a plurality of analysis methods such as biochemistry and blood coagulation will be described.
- FIG. 5 is a diagram for explaining creation of a registration pattern on the display unit according to the present embodiment.
- the identification information display unit 508 is registered by assigning the name “routine 2 (biochemistry / coagulation)” to “registration pattern 3” which is the identification name of the third registration pattern in the registration pattern display unit 501. is doing.
- grouping by analytical techniques biological and coagulation in this example is added here.
- Specimens necessary for biochemical analysis are registered at installation positions 1 to 50, and specimens necessary for blood coagulation analysis are registered at installation positions 56 to 97.
- the operator by separating the installation location for each analysis technique, it is possible for the operator to easily identify the installation position and the specimen related to the analysis technique. For example, in the case where there are 55 places on the inner circumference side and 55 places on the outer circumference side, respectively, for a total of 110 places in the specimen rack 102, the outer circumference corresponding to the installation positions 1 to 55 is biochemical.
- the occurrence frequency and quantity of specimens may differ, but according to the present invention, analysis by a plurality of analysis methods is continued without stopping the apparatus. -It can start and end, and can be used efficiently.
- an automatic analyzer capable of automatically assigning consecutive position numbers for each classification of specimens or the like when creating a registered pattern will be described.
- FIG. 8 is a diagram for explaining creation of a registered pattern on the display unit according to the present embodiment.
- the display unit 118 c displays the sample rack 102 in the sample disk information display unit 810, a solid line or a dotted line frame that displays the installation position of the sample on the sample rack 102, and the type of sample or the like indicated by the frame. is doing.
- the registration pattern shown in FIG. 8 has the same contents as the registration pattern described above with reference to FIG. 5, and the installation position is divided between biochemical analysis and blood coagulation analysis.
- Each frame to which the type of specimen is assigned can be set one by one.
- the registration pattern of the sample rack 102 can be input, and this registration pattern is set for each of the label names “registration pattern 1” and “registration pattern 2” and applied with the mouse 118a
- a desired registration pattern can be applied to the apparatus. According to this, it is possible to automatically assign consecutive position numbers for each classification of specimens, etc., and for example, mixing such as a calibrator interrupting between position numbers of different classifications, for example, general specimens. It is possible to prevent the erroneous operation by the operator.
- an example of a sample rack provided with an indicator lamp will be described.
- FIG. 9 is a diagram showing a basic configuration of the sample rack according to the present embodiment.
- FIG. 6 is a view in which indicator lamps 21 corresponding to the respective installation positions of the sample containers 103 of the sample rack 102 are provided outside the sample rack 102.
- the indicator lamp 21 corresponding to the outer periphery of the sample rack 102 and the indicator lamp 22 corresponding to the inner periphery are provided, and the position where the name number of the position of the sample rack and the name number of the indicator lamp 21 correspond to each other is provided.
- the origin position of the rotation operation of the sample rack 102 is set.
- the color of the indicator lamp 21 and the type of the sample registered at each installation position can be indicated by the lighting method such as lighting, extinguishing, and blinking. Even if the sample rack 102 is not at the origin position, the display lamp 21 corresponding to the installation position of the sample rack 102 can be turned on at an arbitrary position where the sample rack 102 is stopped to indicate the registered contents. According to this, the operator can know the type of the sample applied on the display unit 118c, and can check on the apparatus, and can prevent the installation of the sample different from the registered content. it can.
- a sheet for displaying the contents of the registered pattern may be installed at the center of the sample rack 102 (not shown).
- a different sheet is prepared for each registered pattern, and the operator installs a sheet corresponding to the set registered pattern, thereby reducing the risk of erroneous placement of the specimen or the like.
- Not only registered patterns but also detailed items can be recorded and displayed on the sheet as necessary, so that the apparatus can be operated more efficiently.
- FIG. 10 is a diagram showing a basic configuration of the sample rack according to the present embodiment.
- Identification members 1001a to 1001f having identification information for determining sections are installed at the respective installation positions of the sample containers 103 of the sample rack 102.
- the operator installs identification members 1001a to 100f having identification information indicating the start positions of the sections for the types of samples and the like on the sample rack 102,
- An instruction to start the determining operation is transmitted to the control unit 120 and displayed on the display unit 118c.
- the sample rack 102 rotates, and the identification information of the identification members 1001a to 1001f installed on the outer circumference and the inner circumference is read by the barcode reader 124 installed at the reading position on the inner circumference and the outer circumference, and the identification member 1001a is read.
- the identification information of .about.f and the information on the installed position are linked and stored in the storage unit 119 (see FIG. 1).
- the sample rack 102 can rotate without stopping if it is a passing speed at which the identification information can be read, and if necessary, at a position where the barcode reader reads the identification information. , You may pause.
- the identification member 1001a at the position of the installation position No. 1 indicates the start position of the section of the quality control sample
- the identification member 1001b at the position of the installation position No. 3 has the section of the calibrator. Indicates the start position.
- the identification members 1001c to 1001e installed at the installation positions Nos. 10, 21, and 30 are similarly indicated as the start positions of the corresponding sections.
- the barcode reader 124 may be used in common for reading sample information.
- the obtained identification information and information regarding the installation position are calculated by the control unit 120 and registered as a new division registration pattern. At this time, the registered pattern number can also be input.
- the registered pattern is displayed on the display unit 118c, and the operator can confirm the contents.
- the control unit 120 controls correctly based on the record information in which the identification member for identification is installed at the installation position so that the dispensing operation is not performed by the sample dispensing probe 101 by mistake. .
- the dedicated identification member 1002 having identification information is installed.
- An identification member installation position 125 can be provided. It is also possible to attach an adapter printed with identification information, which is configured to have a shape that does not hinder the installation of the test tube by utilizing the structure of the installation position of the test tube.
- FIG. 10 only the identification member installation position 125 corresponding to the installation position No. 1 is illustrated and the others are omitted, but can be provided corresponding to each installation position.
- the operator can arrange the identification member at the identification member installation position 125, create a registered pattern partitioned as intended, and can also be used as a mark when installing a specimen or the like.
- the registered pattern registered or applied to the device is displayed on the screen of the display unit 118c, and the operator can easily confirm the content through the screen.
- the apparatus reads the signs of the identification members 1001a to 100f installed in the sample rack 102, and issues a warning to the operator if there is a difference between the sections. .
- the operator either corrects the section through the screen, corrects the installation position of the marker component of the sample rack 102, or corrects both so that the contents match. I do. (Sixth embodiment)
- the unit that can register a partition is set for every sample rack 102.
- a single sample rack 102 is divided into smaller areas, and the registration pattern is divided into each area. A case where the section registration can be performed will be described.
- This area can be freely set by the operator. For example, consider a case where independent areas are set on the inner and outer circumferences of the sample rack 102.
- the operator selects and registers a calibrator, a quality control sample, a general sample, and the like on each of the inner circumference and the outer circumference to create a registration pattern.
- the number of analyzes is relatively small, or there are many opportunities to perform various types of analysis so that a part of the sample rack 102 can be sufficiently processed by being assigned to a general sample. Therefore, when there are many opportunities to use many kinds of calibrators, the inner circumference is assigned to the calibrator, and the operator can assign the outer circumference to the general specimen and the quality control sample, which is effective.
- the operator switches the registered pattern of the sample rack 102, if there is a sample or the like still installed in the sample rack 102, the operator is installed so as to match the registered pattern before the sample is switched. There may be a case where there is a problem that it is not clear whether there is any, or conversely, whether it is installed so as to match the registered pattern after switching.
- the present embodiment corresponds to such a case.
- FIG. 14 is a flowchart showing an operation for detecting an error when switching registered patterns in the automatic analyzer according to the present embodiment.
- step 1401 the previous analysis result is output (S1401).
- a new analysis content is requested in step 1402 (S1402), and it is determined in step 1403 whether a necessary registration pattern is selected for the requested analysis content (S1403).
- the registration pattern can be selected by the operator via the operation unit 118 as described above.
- step 1404 it is determined in step 1404 whether to check whether there is a sample on the rack or not (S1404). When confirming, it progresses to the process after step 1406 mentioned later. If the confirmation is unnecessary, the process proceeds to step 1411, and the requested analysis content is captured or input (S1411).
- step 1405 the registration pattern is changed in step 1405 (S1405), and the presence or absence of a sample on the rack is confirmed in step 1406 (S1406).
- the sample rack 102 is rotated, and the presence or absence of a sample in the sample rack 102 is determined by a detector (not shown) with respect to the installation positions on the inner periphery and outer periphery along the rotation direction. Done.
- the detector instead of the detector or by reading the identification information with the barcode reader 124 installed together with the detector, not only the presence / absence of the sample etc. but also the match with the registered pattern may be discriminated. .
- step 1408 determines whether the installed sample or the like is an analysis target (S1408). This determination is made by confirming whether the installed sample or the like matches the registered pattern before switching, or matches the registered pattern selected after switching.
- step 1411 the analysis content requested in step 1411 is taken in or input (S1411). In this case, it is assumed that the installed specimen or the like is intended for reexamination.
- the operator is alerted in step 1409 (S1409).
- various methods are included in alerting, for example, there is a method of displaying the fact on the screen on the display unit 118c and indicating that the sample is at risk of causing an analysis error.
- step 1407 if the installation of a sample or the like is confirmed in step 1407, it is possible to alert the operator first before proceeding to step 1408. In this case, the operator can check the specimen or the like more carefully.
- sample racks 102 are desirably installed at all times, such as a cleaning solution and a sample dilution solution, and thus the device prevents unnecessary alerts from being made in this way. be able to.
- step 1409 the operator is alerted in step 1409, and the operator confirms the specimen and the like, and if the remaining specimen is unintentionally left, the instruction is given in step 1410 to take it out. (S1410). By doing so, it is possible to match the sample or the like installed in the rack with the contents of the analysis request.
- step 1409 can be omitted, and the apparatus can automatically perform an operation of taking out a specimen or the like.
- step 1412 based on the analysis content (necessary sample and the like and the corresponding installation position) captured or input in step 1411, the sample and the like are installed at a corresponding position on the rack (S1412). After installation, analysis is performed in step 1413 (S1413), and the analysis result obtained in step 1414 is output (1414).
- the detector for detecting the presence or absence of the sample on the reagent rack 102 or the reading of the identification information by the barcode reader 124 only checks the installation position used in the new analysis. Confirmation time can be shortened. Further, it is possible to save time and time required for the operator to take out the specimen remaining at other installation positions. That is, the analysis throughput can be improved.
- the timing for starting the operation for checking the presence or absence of the sample in step 1407 can be performed at a timing other than immediately after the registration pattern change in step 1405. For example, if the operator has instructed to resume analysis through the operation unit 118 and is a stage before the apparatus resumes the analysis operation, an operation sequence for confirming the presence / absence of the operation is set at another timing. can do.
- Various modes can be set in accordance with the operator's preference and the configuration of the operation unit 118 that it is considered inefficient to remove the specimen or the like left before the registration pattern is changed.
- the above-described apparatus configuration capable of setting an area obtained by dividing the sample rack 102 can be combined with an apparatus configuration for detecting a sample or the like remaining in the sample rack 102 when the registered pattern is switched.
- Samples are uniformly installed in the sample rack 102, the analysis is performed, and before the analysis is completed, that is, according to the analysis request, before all the samples are aspirated and collected by the sample dispensing probe 101, a new interruption is performed. Assume that a sample that needs to be analyzed is brought in. Furthermore, it is assumed that the sample or the like is a calibrator that is not in the current registered pattern, and the operator first completes the analysis of the calibrator generated by the interruption, and then completes the analysis while being installed in the sample rack 102.
- the sample rack 102 divides the area into an inner periphery and an outer periphery, and the registered pattern before switching is configured with a general sample as the center.
- the analysis of a sample or the like installed in advance is started from the inner periphery, and the collection of the sample is stopped in the middle of the outer periphery.
- the interrupt calibrator after removing the sample and the like that have been left in the inner periphery, only the registered pattern on the inner periphery is changed to a registered pattern corresponding to this calibrator. In this way, there is no need to change the outer peripheral registration pattern.
- the apparatus can be operated more efficiently.
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Abstract
Description
(第1の実施の形態)
〈装置の基本構成〉
本実施の形態では、複合型の自動分析装置(以下、単に自動分析装置、または装置と称することがある)の一例として、血液や尿等の生体試料(以下、単に試料と称する)および試薬を混合してから生化学分野の分析項目を処理し、また、血液凝固分野の分析項目を処理することができる装置を例にとって説明する。
図2は、本実施の形態に係る検体ラック102の基本構成を概略的に示す図である。
〈動作フローについて〉
図11~13を用いて、本実施の形態に係る基本的な動作フローについて説明する。
例えば、6つの登録パターンを作成した場合、番号1~6のうちいずれの番号の登録パターンについて、詳細項目を割り当てるのかを選択する。
〈表示画面について〉
図3乃至5は、本実施の形態に係る表示部118cを概略的に示す図である。図3Aは、本実施の形態に係る表示部上における登録パターンの作成等を説明する図である。図3Aでは、表示部118cは、登録パターン表示部301にて、登録パターン1から登録パターン5までの、5通りの検体情報の登録パターンを選択して表示する例を示す。検体情報として、少なくとも検体ラック102の設置位置の番号と、そこに割り当てられた検体等の種類が登録され、これらは検体情報表示部302に表示されている。例えば、検体ラック102の設置位置がNo.1~110まで提供される場合には、精度管理試料やキャ
リブレーター、各種の検体や、洗浄液の設置位置を、設置位置の開始番号と終了番号とで区画を区切り、登録する。ここで、登録パターン表示部301や、選択された登録パターンに関する検体等の情報を表示する検体情報表示部302は、分析動作中も常に表示することができる。
上述の例の他に、区画の登録方法として、図3Bに示すように、検体情報表示部302において精度管理試料やキャリブレーター等といった検体等の登録数をオペレーターが入力することで、装置は登録数に応じてそれらの開始番号及び終了番号順序よく自動的に割り振ることもできる。
。緊急検体は検査室に持ち込まれるタイミングによらず、優先的に分析されることが必要であり、これは検体ラック102の登録パターンによらず常に一に定められた位置を確保することで、オペレーターは容易に設置位置を把握し、緊急検体の検体容器103を確実に設置することができる。
(第2の実施の形態)
第1の実施の形態では、生化学分析や血液凝固分析等の分析手法が単独で、もしくは混在した登録パターンを作成する自動分析装置の例について説明した。
(第3の実施の形態)
本実施の形態では、登録パターンの作成において、検体等の分類ごとに連続した位置番号を自動的に割り当てることができる自動分析装置について説明する。
(第4の実施の形態)
本実施の形態では、表示灯を備えた検体ラックの例について説明する。
(第5の実施の形態)
本実施の形態では、識別部材を備えた検体ラックの例について説明する。
(第6の実施の形態)
上述の実施の形態では、区画の登録ができる単位を全検体ラック102ごととしたが、本変形例では、単一の検体ラック102をより小さい領域に分割し、そのそれぞれの領域において、登録パターンとして区画登録することができる場合について説明する。
(第7の実施の形態)
本実施の形態では、複数の分析を実行する場合における登録パターンの切り替え時に、エラーを検知する機能(以下、単にエラー検知機能と称することがある)を備えた自動分析装置の例について説明する。
21、22・・・表示灯
100・・・自動分析装置
101・・・検体分注プローブ(試料分注機構)
102・・・検体ラック
103・・・検体容器(試料容器)
104・・・反応容器
105・・・検体用シリンジポンプ
106・・・試薬分注プローブ(試薬分注機構)
107・・・試薬ラック
108・・・試薬容器
109・・・試薬昇温機構
110・・・試薬用シリンジポンプ
111・・・反応容器ストック部
112・・・反応容器搬送機構
113・・・検出ユニット
114・・・反応容器設置部
115・・・光源
116・・・検出部(光センサ)
117・・・反応容器廃棄部
118・・・操作部
118a・・・マウス
118b・・・キーボード
118c・・・表示部
119・・・記憶部
120・・・制御部
120a・・・全体制御部
120b・・・測定制御部
121・・・A/D変換器
122・・・インタフェース
123・・・プリンタ
124・・・バーコードリーダー
125・・・識別部材設置位置
301、401、501、601、701、801、1501・・・登録パターン表示部302、402、502、602、702・・・検体情報表示部
303、403、503、603、703・・・詳細項目表示部
304・・・登録リスト表示部
305・・・設置位置割り当て表示部
306、406、506、606、706、806・・・適用ボタン
307・・・詳細項目設定対象表示部
308、408、508、608、708・・・識別名称表示部
609、709、809・・・ステータス表示部
610、710、810・・・分析結果表示部
1001・・・識別部材
1509・・・(分析)スタートボタン
1510・・・登録パターン情報表示部
Claims (27)
- 試料を分析する自動分析装置であって、
試料を収容する容器と、
前記容器を複数載置する一のラックと、
制御部と、を備え、
前記制御部は、
前記一のラックに対して、前記容器が設置される位置の情報と、前記容器に収容される試料の情報と、を関連付けた登録パターンを複数作成し、
当該複数作成された登録パターンを記憶し、
当該記憶された複数の登録パターンのうち、選択された一の登録パターンを前記一のラックに適用し、前記試料を分析することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記制御部は、
当該記憶された複数の登録パターンのうち、選択された一の登録パターンに基づいて、前記一のラックにおける設置位置への前記試料の載置を指示することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記試料の分析に関する情報を表示する表示部を有し、
前記制御部は、
当該一のラックに適用された登録パターンの内容と、当該試料の分析の開始を指示する指示部とを併せて前記表示部に表示することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記試料の分析に関する情報を表示する表示部を有し、
前記制御部は、
前記一のラックに適用する登録パターンを選択する選択部、または、当該選択された登録パターンの情報を、前記表示部に常に表示することを特徴とする自動分析表示。 - 請求項1に記載された自動分析装置であって、
前記制御部は、
前記試料を分析する手法の種類に基づいて、前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項5に記載された自動分析装置であって、
前記制御部は、
前記試料を分析する手法の種類ごとに、前記一のラックにおける設置位置に前記容器が連続して載置されるように、前記登録パターンを作成することを特徴とする自動分析装置
。 - 請求項6に記載された自動分析装置であって、
前記試料を分析する手法には、生化学分析と、血液凝固分析とを含むことを特徴とする自動分析装置。 - 請求項5に記載された自動分析装置であって、
前記一のラックは、それぞれに前記容器を載置できる外周部と、内周部と、から構成され、
前記制御部は、
前記試料を分析する手法の種類ごとに、それぞれ前記一のラックにおける外周部または内周部のいずれかの設置位置に前記容器が載置されるように、前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記容器が設置される位置の情報は、前記容器が設置される開始位置から、終了位置までの複数の設置位置を有する区画を含み、
前記制御部は、前記区画のそれぞれに対して、前記容器に収容される試料の情報が重複して関連付けられないように、前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項9に記載された自動分析装置であって、
前記制御部は、
当該区画における、開始位置から、終了位置までの複数の設置位置に、連続して前記容器が載置されるように、前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項9に記載された自動分析装置であって、
前記制御部は、
当該区画における前記容器の設置数に関する情報に基づいて、
前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項9に記載された自動分析装置であって、
前記制御部は、
当該区画における開始位置と、前記容器の設置数に関する情報に基づいて、
前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記容器が設置される位置の情報は、前記容器が設置される開始位置から、終了位置までの複数の設置位置を有する区画を含み、
前記制御部は、
前記区画を複数決定し、当該決定された区画に含まれるそれぞれの設置位置ごとに、前記試料の詳細情報を割り当てることを特徴とする自動分析装置。 - 請求項13に記載された自動分析装置であって、
前記制御部は、
前記試料の詳細な情報が入力されたときには、対応する区画を前記一のラックに適用することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記制御部は、
当該作成された複数の登録パターンを、前記一のラックに適用する順序をスケジューリングすることを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記試料の分析に関する情報を表示する表示部を有し、
前記制御部は、
前記ラックの構成を模式的に示す模式図を前記表示部に表示し、当該ラックの模式図において、色彩、記号等により、前記ラックにおける設置位置の情報を識別することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記試料の分析に関する情報を表示する表示部を有し、
前記制御部は、
前記ラックの構成を模式的に示す模式図を前記表示部に表示し、当該ラックの模式図上において、前記ラックにおける設置位置の開始位置から、終了位置までの区画を決定することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記制御部は、
前記一のラックにおいて、緊急の分析を要する緊急試料を収容する容器の設置位置が、当該複数の登録パターンにおいて固有となるように、前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記容器は、前記試料のほかに洗浄液、分析の前処理液を収容可能であって、
前記制御部は、
前記一のラックにおいて、
少なくとも、前記洗浄液または前記前処理液を収容する容器の設置位置が、当該複数の登録パターンにおいて固有となるように、前記登録パターンを作成することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記容器が設置される位置の情報は、前記容器が設置される開始位置から、終了位置までの複数の設置位置を有する区画を含み、
前記一のラックには、前記区画を識別するための情報を有する識別部材と、当該識別部材が有する情報を読み取る検出部と、を有し、
前記制御部は、
当該検出部が読み取った情報と、前記識別部材が配置された位置との対応に基づいて、
前記区画の決定、または前記試料の詳細な情報の前記区画への割り当てがなされた登録パターンを生成することを特徴とする自動分析装置。 - 請求項20に記載された自動分析装置であって、
前記識別部材の設置位置を、前記容器の設置位置とは別の位置であって、かつ、前記容器の設置位置と対応するように配置することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記制御部は、
前記一のラックにおける複数の設置位置を有する所定の領域ごとに、対応する登録パターンを作成することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記制御部は、
当該記憶された複数の登録パターンのうち、少なくともいずれかの登録パターンが変更されたときに、前記一のラックに設置されている容器の有無を確認することを特徴とする自動分析装置。 - 請求項23に記載された自動分析装置であって、
前記制御部は、
当該確認の結果、前記一のラックに設置されている容器がある場合には、前記表示部に警告を表示することを特徴とする自動分析装置。 - 請求項23に記載された自動分析装置であって、
前記制御部は、前記一のラックにおける設置位置のうち、当該確認を選択的に行う特定の設置位置を設定することを特徴とする自動分析装置。 - 請求項1に記載された自動分析装置であって、
前記試料は、少なくとも因子欠乏血漿を有することを特徴とする自動分析装置。 - 試料を収容する容器と、
前記容器を複数載置する一のラックと、
制御部と、を備え、試料を分析する自動分析装置における分析方法において、
前記制御部は、
前記一のラックに対して、前記容器が設置される位置の情報と、前記容器に収容される試料の情報と、を関連付けた登録パターンを複数作成し、
当該複数作成された登録パターンを記憶し、
当該記憶された複数の登録パターンのうち、選択された一の登録パターンを前記一のラックに適用し、前記試料を分析することを特徴とする分析方法。
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