WO2016047499A1 - Fil-guide - Google Patents

Fil-guide Download PDF

Info

Publication number
WO2016047499A1
WO2016047499A1 PCT/JP2015/076135 JP2015076135W WO2016047499A1 WO 2016047499 A1 WO2016047499 A1 WO 2016047499A1 JP 2015076135 W JP2015076135 W JP 2015076135W WO 2016047499 A1 WO2016047499 A1 WO 2016047499A1
Authority
WO
WIPO (PCT)
Prior art keywords
guide wire
central axis
recess
reshape
shape
Prior art date
Application number
PCT/JP2015/076135
Other languages
English (en)
Japanese (ja)
Inventor
大 秋友
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Publication of WO2016047499A1 publication Critical patent/WO2016047499A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09058—Basic structures of guide wires
    • A61M2025/09083—Basic structures of guide wires having a coil around a core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/0915—Guide wires having features for changing the stiffness
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09175—Guide wires having specific characteristics at the distal tip

Definitions

  • the present invention relates to a guide wire.
  • Guidewires can be used to treat difficult-to-surgical sites, such as PTCA (Percutaneous Transluminal Coronary Angioplasty), or for treatment that is minimally invasive to the human body, Used to guide catheters used for examinations such as angiography.
  • PTCA Percutaneous Transluminal Coronary Angioplasty
  • a guide wire used for PTCA surgery is inserted to the vicinity of the target vascular stenosis portion together with the balloon catheter with the tip of the guide wire protruding from the tip of the balloon catheter. Guide to near.
  • the blood vessel is intricately curved, and the guide wire used to insert the balloon catheter into the blood vessel has moderate flexibility and resilience to bending, and pushability to transmit the proximal end operation to the distal end.
  • torque transmission properties collectively referred to as “operability”
  • tensile strength tensile strength
  • kink resistance bending resistance
  • the like are required as a structure for obtaining moderate flexibility and resilience.
  • Some use super-elastic wires such as Ni-Ti (for example, see Patent Document 1). It is also known that a reinforcing material is separately provided at the tip of the core material in order to improve torque transmission.
  • the guide wire when used in PTCA surgery, the guide wire has been made to reduce the pushability by thinning the tip of the core material so as to avoid the penetration of the blood vessel wall and be used as safely as possible. In order to maintain sufficient tensile strength to avoid breakage, the cross-sectional area should not be reduced excessively.
  • the tip of the core material may be shaped. In order to facilitate this shaping, it is known to press the tip of the core material into a flat plate shape. This reduces the pushability of the tip and improves safety.
  • torque transmission performance is remarkably lowered, and when the reinforcing material is provided separately, torque transmission is improved, but it is difficult to perform such shaping.
  • An object of the present invention is to provide a guide wire that can be easily shaped at the distal end portion of the guide wire and is excellent in torque transmission to the distal end portion.
  • a guide wire comprising a core wire having a long shape and a thin tip portion,
  • the guide wire has a rod shape that is not a flat shape, and has a plurality of recesses formed on an outer peripheral portion thereof and disposed along a central axis direction of the core wire.
  • the plurality of recesses include a first recess on the near side of the center axis and a second recess on the back side of the center axis in a side view of the guide wire.
  • each of the recesses is a groove along a circumferential direction of the outer peripheral portion.
  • the sizes of the recesses are the same.
  • torque can be reliably transmitted to the distal end portion of the guide wire by forming the tip portion of the rod shape which is not a flat shape, that is, excellent torque transmission.
  • the bending direction at the distal end portion of the guide wire becomes only one direction, and shaping is performed. Becomes easy.
  • the area decrease in each cross section can be suppressed, so the decrease in tensile strength is reduced.
  • FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the guide wire of the present invention.
  • FIG. 2 is a view of the core wire (reshaping portion) provided in the guide wire shown in FIG. 1 as viewed from the direction of arrow A in the drawing.
  • FIG. 3 is a perspective view of a core wire (reshaping portion) provided in the guide wire shown in FIG. 4 is a cross-sectional view taken along line BB in FIG.
  • FIG. 5 is a cross-sectional view taken along the line CC in FIG.
  • FIG. 6 is a cross-sectional view of the reshape portion of the core wire provided in the guide wire (second embodiment) of the present invention.
  • FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the guide wire of the present invention.
  • FIG. 2 is a view of the core wire (reshaping portion) provided in the guide wire shown in FIG. 1 as viewed from the direction of arrow A in the drawing.
  • FIG. 3
  • FIG. 7 is a cross-sectional view of the reshape part of the core wire provided in the guide wire (second embodiment) of the present invention.
  • FIG. 8 is a plan view of the reshape portion of the core wire provided in the guide wire (third embodiment) of the present invention.
  • FIG. 9 is a plan view of the reshape portion of the core wire provided in the guide wire (fourth embodiment) of the present invention.
  • FIG. 10 is a plan view of the reshape part of the core wire provided in the guide wire (fifth embodiment) of the present invention.
  • FIG. 11 is a plan view of a reshape portion of a core wire included in the guide wire (sixth embodiment) of the present invention.
  • FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the guide wire of the present invention.
  • FIG. 2 is a view of the core wire (reshaping portion) provided in the guide wire shown in FIG. 1 as viewed from the direction of arrow A in the drawing.
  • FIG. 3 is a perspective view of a core wire (reshaping portion) provided in the guide wire shown in FIG. 4 is a cross-sectional view taken along line BB in FIG.
  • FIG. 5 is a cross-sectional view taken along the line CC in FIG.
  • the right side in FIGS. 1 to 3 (same as in FIGS.
  • FIGS. 8 to 11 is referred to as “base end”, and the left side is referred to as “tip”. Also, in FIGS. 1 to 3 (the same applies to FIGS. 8 to 11), for the sake of easy understanding, the length direction of the guide wire is shortened and the thickness direction of the guide wire is exaggerated and schematically illustrated. The ratio between the length direction and the thickness direction is very different from the actual one.
  • a guide wire 1 shown in FIG. 1 is a guide wire for a catheter that is used by being inserted into the lumen of a catheter (including an endoscope) by PTCA, for example.
  • the total length of the guide wire 1 is not particularly limited, but is preferably about 200 to 5000 mm.
  • the guide wire 1 includes a core wire (wire body) 2 composed of a single long wire, and a spiral coil 5 installed at the tip end portion (tip end portion) of the core wire 2. ing.
  • the core wire 2 includes a reshape portion 3 located on the distal end side and a main body portion 4 located on the proximal end side of the reshape portion 3.
  • the reshape portion 3 is a portion that is located at the tip of the core wire 2 and can be reshaped (shaped) with a small diameter.
  • the reshape portion 3 is bent or curved in the arrow direction in FIG. 1 so as to be deformed into a desired shape.
  • a doctor or the like previously sets the distal end of the guide wire to a desired shape. In this way, bending the tip of the guide wire into a desired shape is called reshaping.
  • the reshape part 3 reshape can be performed easily and reliably, and the operativity at the time of inserting the guide wire 1 in a biological body improves markedly.
  • tip part may be attached
  • the main body 4 is a thicker and longer part than the reshape part 3.
  • the main body portion 4 has a tapered portion 41 having a tapered shape in which the outer diameter gradually increases in the proximal direction, and a constant outer diameter portion 42 having a constant outer diameter.
  • the rigidity (bending rigidity, torsional rigidity) of the core wire 2 can be gradually reduced toward the distal end.
  • the guide wire 1 can obtain a good stenosis portion passing through and flexibility at the distal end portion, improve followability to a blood vessel and the like, and can be prevented from being bent.
  • the taper angle (decrease rate of the outer diameter) of the taper portion 41 may be constant along the longitudinal direction of the core wire 2 or may have a portion that varies along the longitudinal direction. For example, a portion where a relatively large taper angle and a relatively small portion are alternately formed a plurality of times may be used.
  • the outer diameter constant portion 42 has the same outer diameter as the maximum outer diameter of the tapered portion 41, and is a portion having relatively high rigidity. Thereby, the pushing property to the front-end
  • the base end surface 421 of the constant outer diameter portion 42 is preferably rounded.
  • a coil 5 is disposed on the outer periphery of the reshape portion 3 of the core wire 2 so as to cover the reshape portion 3.
  • the coil 5 reduces the contact area of the surface of the core wire 2 with the inner wall of the catheter or the surface of the living body, thereby reducing sliding resistance, and as a result, the operability of the guide wire 1 is further improved.
  • the reshape portion 3 is inserted through the central portion inside the coil 5, and the reshape portion 3 is not in contact with the inner surface of the coil 5. As a result, a gap 11 is formed between the coil 5 and the reshapable portion 3, and the pushability with respect to the blood vessel wall can be lowered.
  • the coil 5 is formed by winding a wire 51 in a spiral shape along the circumferential direction of the reshapable portion 3.
  • one strand 51 may be spirally wound, or a plurality of strands 51 may be spirally wound.
  • the adjacent strands 51 of the coil 5 are in contact with each other and are in a so-called densely wound state. These strands 51 generate a force (compression force) that pushes them in the axial direction of the core wire 2 in a natural state where no external force is applied.
  • the guide wire 1 is not limited to this, and there may be a so-called sparsely wound portion where the adjacent strands 51 of the coil 5 are separated from each other.
  • the constituent material of the strand 51 is not particularly limited, and may be either a metal material or a resin material.
  • the metal material include X-ray opaque materials such as stainless steel, noble metals such as Au and Pt, and alloys containing the noble metals (for example, Pt—Ni alloys).
  • X-ray opaque materials such as stainless steel, noble metals such as Au and Pt, and alloys containing the noble metals (for example, Pt—Ni alloys).
  • X-ray opaque material When an X-ray opaque material is used, X-ray contrast properties are obtained at the distal end portion of the guide wire 1, and it can be inserted into the living body while confirming the position of the distal end portion under X-ray fluoroscopy.
  • the coil 5 may be a combination of two or more materials.
  • the strand 51 on the distal end side of the coil 5 can be made of an X-ray opaque material such as the Pt—Ni alloy, and the strand 51 on the proximal end side of the coil 5 can be made of stainless steel.
  • the part located on the distal end side of the coil 5 particularly, the part including the reshapable portion 3 can be emphasized more than the part located closer to the proximal end ( Therefore, the position of the most distal portion (the portion where the reshape portion 3 exists) of the guide wire 1 can be visually recognized more clearly.
  • the wire diameter of the strand 51 of the coil 5 may be the same over the entire length of the coil 5, but the wire diameter of the strand 51 may be different between the distal end side and the proximal end side of the coil 5.
  • the wire diameter of the strand 51 may be smaller (or larger) on the distal end side of the coil 5 than on the proximal end side.
  • the outer diameter of the coil 5 may be the same over the entire length of the coil 5, but the outer diameter of the coil 5 may be different between the distal end side and the proximal end side of the coil 5.
  • the outer diameter of the coil 5 may be smaller on the distal end side of the coil 5 than on the proximal end side.
  • the coil 5 is fixed to the core wire 2 at two locations. That is, the distal end portion of the coil 5 is fixed to the distal end of the reshapable portion 3 via a fixing material (fixing portion) 52, and the proximal end portion of the coil 5 is located in the middle of the tapered portion 41 via the fixing material (fixing portion) 53. It is fixed.
  • the coil 5 can be securely fixed to the core wire 2 while preventing the tip portion of the guide wire 1 (the portion where the coil 5 is present) from being impaired. it can.
  • the reshape portion 3 can be securely fixed to the coil 5, and the shape of the shaped reshape portion 3 can be secured. Can be held properly.
  • Each of the fixing materials 52 and 53 is preferably made of solder (brazing material).
  • the fixing materials 52 and 53 may be adhesives.
  • the method for fixing the coil 5 to the core wire 2 is not limited to the above-described fixing material, and for example, welding may be used.
  • the distal end surface 521 of the fixing material 52 is preferably rounded.
  • a resin coating layer 6 that covers the whole (or a part) of the core wire 2 is provided on the proximal end side of the fixing material 53 of the core wire 2.
  • the resin coating layer 6 can be formed for various purposes. As an example, the operability of the guide wire 1 is reduced by reducing the friction (sliding resistance) of the guide wire 1 and improving the slidability. May be improved.
  • the resin coating layer 6 is preferably made of a material that can reduce friction as described below.
  • the frictional resistance (sliding resistance) with the inner wall of the catheter used together with the guide wire 1 is reduced, the slidability is improved, and the operability of the guide wire 1 in the catheter becomes better.
  • the guide wire 1 can be reliably prevented from being kinked (bent) or twisted when the guide wire 1 is moved and / or rotated in the catheter.
  • materials that can reduce such friction include polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polyesters (PET, PBT, etc.), polyamides, polyimides, polyurethanes, polystyrenes, polycarbonates, silicone resins, fluorine resins ( PTFE, ETFE, etc.) or a composite material thereof.
  • polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polyesters (PET, PBT, etc.), polyamides, polyimides, polyurethanes, polystyrenes, polycarbonates, silicone resins, fluorine resins ( PTFE, ETFE, etc.) or a composite material thereof.
  • the resin coating layer 6 may be a single layer or a laminate of two or more layers (for example, an inner layer made of a material that is more flexible than an outer layer).
  • the reshape portion 3 is disposed at the most distal end portion of the core wire 2, and the reshape portion 3 is formed integrally with the main body portion 4.
  • manufacture of the core wire 2 (guide wire 1) becomes easy.
  • the constituent material of the core wire 2 is not particularly limited.
  • stainless steel for example, SUS304, SUS303, SUS316, SUS316L, SUS316J1, SUS316J1L, SUS405, SUS430, SUS434, SUS444, SUS429, SUS430F, SUS302, and all other types of SUS.
  • Various metal materials such as piano wire can be used, and among these, stainless steel is preferable.
  • a superelastic alloy exhibiting superelasticity in vivo can be used as a constituent material of the core wire 2.
  • Superelastic alloys include any shape of stress-strain curve caused by tension, including those where the transformation point of As, Af, Ms, Mf, etc. can be measured remarkably, and those that cannot be deformed. However, everything that returns to its original shape by removing stress is included.
  • the preferred composition of the superelastic alloy is a Ni—Ti alloy such as a Ni—Ti alloy of 49 to 52 atomic% Ni, a Cu—Zn alloy of 38.5 to 41.5 wt% Zn, 1 to 10 wt% X Cu—Zn—X alloy (X is at least one of Be, Si, Sn, Al, and Ga), Ni-Al alloy of 36 to 38 atomic% Al, and the like. Of these, the Ni—Ti alloy is particularly preferable.
  • heat treatment is performed on the portion of the core wire 2 that is to be the reshaped portion 3.
  • the physical property in the said part changes, ie, superelasticity reduces or lose
  • the portion may be cold worked.
  • a superelastic alloy typified by a Ni—Ti alloy is excellent in adhesion to the resin coating layer 6.
  • the reshapable portion 3 is not flat, that is, in the present embodiment, there are a plurality of circular cross-sectional portions 31 (14 in the configuration shown in FIG. 1) having a circular cross-sectional shape. However, it is a rod-shaped part. These circular cross-sections 31 are intermittently arranged along the central axis O 2 of the core wire 2. And in the outer peripheral part between adjacent circular cross-section parts 31, the 1st recessed part (1st defect
  • first recesses 32 and the second recesses 33 are alternately arranged so as not to overlap in the side view of the guide wire 1 (hereinafter, this arrangement relationship is referred to as “alternate arrangement”. Say). Therefore, as shown in FIG. 2, the first recess 32 is located on the front side (the front side of the drawing) from the center axis O 2 and the second recess 33 is the center axis O 2 as viewed from the side of the guide wire 1. It will be in the state located in the back side (paper surface back side).
  • the reshape portion 3 has a flat shape, that is, a flat plate shape (ribbon shape), and the thickness thereof is smaller than the outer diameter (maximum outer diameter) ⁇ d 31 of the circular cross section 31. .
  • the reshapable portion 3 can be easily bent and reshapable, but the torque transmission at the reshapable portion 3 may be significantly reduced. Therefore, for example, even if a torque is applied to the guide wire from the proximal end side so that the distal end portion of the guide wire passes through a stenosis portion (lesioned portion) in the blood vessel, the distal end portion does not rotate 1: 1. As a result, it may be difficult to pass through the constriction.
  • a minute force applied to the distal end portion of the guide wire 1 by the narrowed portion is not transmitted to the proximal end portion of the guide wire 1 and it becomes difficult to obtain information such as the hardness of the narrowed portion.
  • reshapable portion 3 is not a flat shape, and is intended to round sectional portions 31 is intermittently disposed along the central axis O 2.
  • the reshapable portion 3 as a whole becomes so-called firm, that is, the torsional rigidity is increased and the torque transmission is improved.
  • non-circular cross-sectional portion 34 the cross-sectional shape of the portion of the reshapable portion 3 where the first concave portion 32 and the second concave portion 33 are formed.
  • the shape is such that part of the circle is missing. Therefore, the width in the pressing direction of the non-circular cross section 34 is smaller than the thickness of the circular cross section 31.
  • each non-circular cross-sectional portion 34 can be preferentially deformed over each circular cross-sectional portion 31, and thus the shape of the reshaped portion 3.
  • the attachment can be easily and reliably performed in one direction along the non-circular cross section 34, and the shape is maintained.
  • the guide wire 1 can be easily shaped at the tip, that is, the reshape portion 3, and has excellent torque transmission to the reshape portion 3.
  • the first recesses 32 and the second recesses 33 are arranged alternately. Thereby, since the circular cross-sectional part 31 remains reliably (formed) between the 1st recessed part 32 and the 2nd recessed part 33, the fall of torque performance can be suppressed.
  • the alternating arrangement can prevent the thickness of the reshapable portion 3 from becoming extremely thin, thereby preventing a decrease in tensile strength and shape maintainability.
  • each recess has the same size.
  • the maximum depth u of each recess is preferably 1% or more and 50% or less of the outer diameter ⁇ d 31 (maximum outer diameter of the outer peripheral portion of the reshapable part 3) of the circular cross-section 31, preferably 5% or more. More preferably, it is 20% or less.
  • the width w of each recess is preferably 1% or more and 200% or less, and 50% or more and 100% or less of the outer diameter ⁇ d 31 of the circular cross-section 31 (the maximum outer diameter of the outer peripheral portion of the reshapable part 3). More preferably. Due to such a magnitude relationship, for example, the ease of bending is the same when the reshapable portion is bent upward in FIG. 1 and when the reshapable portion is bent downward, thereby improving operability during reshaping.
  • the bottom 321 of the first recess 32 is rounded in an arc shape
  • the bottom 331 of the second recess 33 is also rounded in an arc shape.
  • Second Embodiment 6 and 7 are cross-sectional views of the reshape portion of the core wire provided in the guide wire (second embodiment) of the present invention (the positions of the cross-section in FIG. 6 and the cross-section in FIG. 7 are respectively , Different in the longitudinal direction of the reshapable part).
  • the first recess 32 and the second recess 33 are each configured by a groove along the circumferential direction of the outer peripheral portion of the reshapable portion 3.
  • the length L 1 of each groove 10% or more of the total circumference L 2 of the outer peripheral portion of the reshapable portion 3, but preferably not more than 75%, 15% or more, more preferably 60% or less.
  • the formation of the first concave portion 32 and the second concave portion 33 having such a shape can prevent the torque transmission at the reshape portion 3 from being lowered.
  • FIG. 8 is a plan view of the reshape portion of the core wire provided in the guide wire (third embodiment) of the present invention.
  • a first recess 32 intervals adjacent to the central axis O 2 direction, it varies along the central axis O 2. That is, in this embodiment, the first recess 32 the distance between the centers of adjacent to the center axis O 2 direction (pitch) p 32 are gradually decreased along the distal direction.
  • the interval between the second recess 33 adjacent to the central axis O 2 direction varies along the central axis O 2. That is, in this embodiment, distance between centers of the second recess 33 adjacent to the central axis O 2 direction (pitch) p 33 also gradually decreases along the distal direction.
  • the rigidity (bending rigidity) of the reshape part 3 as a whole can be gradually reduced in the distal direction. Therefore, in the reshape part 3, the distal end portion is the proximal end portion. It becomes easier to bend than.
  • This configuration is effective when the reshapable portion 3 is changing in bendability, that is, when it is desired to gradually increase or decrease the size (strength).
  • FIG. 9 is a plan view of the reshape portion of the core wire provided in the guide wire (fourth embodiment) of the present invention.
  • the first recess 32 intervals adjacent to the central axis O 2 direction, it varies along the central axis O 2. That is, in the present embodiment, the center-to-center distance (pitch) p 32 between the first recesses 32 adjacent in the direction of the central axis O 2 gradually decreases toward the base end direction.
  • the interval between the second recess 33 adjacent to the central axis O 2 direction varies along the central axis O 2. That is, in this embodiment, distance between centers of the second recess 33 adjacent to the central axis O 2 direction (pitch) p 33 also gradually decreases along the proximal direction.
  • the rigidity (bending rigidity) of the reshape part 3 as a whole can be gradually decreased in the proximal direction. Therefore, in the reshape part 3, the proximal side part is the distal side part. It becomes easier to bend than the part.
  • This configuration is effective when the reshapable portion 3 is changing in bendability, that is, when it is desired to gradually increase or decrease the size (strength).
  • FIG. 10 is a plan view of the reshape part of the core wire provided in the guide wire (fifth embodiment) of the present invention.
  • each first recess 32 and the second recess 33 is omitted.
  • the size of each first recess 32 is changed in accordance along the central axis O 2. That is, in the present embodiment, the width w of each first recess 32 gradually increases toward the proximal direction.
  • the maximum depth u of each first recess 32 is the same, but the curvature R of the bottom 321 is different, that is, gradually decreases toward the proximal direction.
  • the rigidity (bending rigidity) of the reshape part 3 as a whole can be gradually decreased in the proximal direction. Therefore, in the reshape part 3, the proximal side part is the distal side part. It becomes easier to bend than the part.
  • This configuration is effective when the reshapable portion 3 is changing in bendability, that is, when it is desired to gradually increase or decrease the size (strength).
  • FIG. 11 is a plan view of a reshape portion of a core wire included in the guide wire (sixth embodiment) of the present invention.
  • each first recess 32 and the second recess 33 is omitted.
  • the size of each first recess 32 is changed in accordance along the central axis O 2. That is, in the present embodiment, the width w of each first recess 32 gradually increases toward the distal end.
  • the maximum depth u of each first recess 32 is the same, but the curvature R of the bottom 321 is different, that is, gradually decreases toward the tip.
  • the rigidity (bending rigidity) of the reshape part 3 as a whole can be gradually reduced in the distal direction. Therefore, in the reshape part 3, the distal end portion is the proximal end portion. It becomes easier to bend than.
  • This configuration is effective when the reshapable portion 3 is changing in bendability, that is, when it is desired to gradually increase or decrease the size (strength).
  • each part which comprises a guide wire is a thing of arbitrary structures which can exhibit the same function. Can be substituted. Moreover, arbitrary components may be added.
  • the guide wire of the present invention may be a combination of any two or more configurations (features) of the above embodiments.
  • the guide wire of the present invention is a guide wire having a long shape and a core wire having a thin tip portion, and the tip portion is formed in a rod shape that is not a flat shape, and is formed on the outer peripheral portion of the guide wire. It has a plurality of recesses arranged along the central axis direction. Therefore, it is easy to shape the tip of the guide wire, and the torque transmission to the tip is excellent.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne un fil-guide qui a une forme allongée et comprend un noyau ayant une section de pointe de petit diamètre. Dans ce fil-guide, la section de pointe est une forme de tige qui n'est pas plate et a de multiples sections renfoncées qui sont formées sur sa section circonférentielle externe et qui sont positionnées selon la direction d'axe central du noyau. Dans des emplacements éloignés des zones dans lesquelles les sections renfoncées sont formées, la forme transversale de la section de pointe est circulaire. En outre, les multiples sections renfoncées comprennent, dans une vue latérale de fil-guide, des premières sections renfoncées qui sont sur le côté proche de l'axe central, et des secondes sections renfoncées qui sont sur le côté éloigné de l'axe central, et à la fois les premières sections renfoncées et les secondes sections renfoncées sont positionnées à différents emplacements dans la direction d'axe central.
PCT/JP2015/076135 2014-09-26 2015-09-15 Fil-guide WO2016047499A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014-196932 2014-09-26
JP2014196932 2014-09-26

Publications (1)

Publication Number Publication Date
WO2016047499A1 true WO2016047499A1 (fr) 2016-03-31

Family

ID=55581026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/076135 WO2016047499A1 (fr) 2014-09-26 2015-09-15 Fil-guide

Country Status (1)

Country Link
WO (1) WO2016047499A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9950137B2 (en) 2009-04-03 2018-04-24 Scientia Vascular, Llc Micro-fabricated guidewire devices formed with hybrid materials
US10232141B2 (en) 2008-12-08 2019-03-19 Scientia Vascular, Llc Micro-cutting systems for forming cuts in products
US10363389B2 (en) 2009-04-03 2019-07-30 Scientia Vascular, Llc Micro-fabricated guidewire devices having varying diameters
US10821268B2 (en) 2016-09-14 2020-11-03 Scientia Vascular, Llc Integrated coil vascular devices
US10953203B2 (en) 2016-07-18 2021-03-23 Scientia Vascular, Llc Guidewire devices having shapeable polymer tips
CN112587782A (zh) * 2020-12-07 2021-04-02 上海璞慧医疗器械有限公司 一种医用导丝
US11052228B2 (en) 2016-07-18 2021-07-06 Scientia Vascular, Llc Guidewire devices having shapeable tips and bypass cuts
US11305095B2 (en) 2018-02-22 2022-04-19 Scientia Vascular, Llc Microfabricated catheter having an intermediate preferred bending section
US11369351B2 (en) 2017-05-26 2022-06-28 Scientia Vascular, Inc. Micro-fabricated medical device having a non-helical cut arrangement
US11406791B2 (en) 2009-04-03 2022-08-09 Scientia Vascular, Inc. Micro-fabricated guidewire devices having varying diameters
US11452541B2 (en) 2016-12-22 2022-09-27 Scientia Vascular, Inc. Intravascular device having a selectively deflectable tip
US12011555B2 (en) 2019-01-15 2024-06-18 Scientia Vascular, Inc. Guidewire with core centering mechanism

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008245852A (ja) * 2007-03-29 2008-10-16 Terumo Corp ガイドワイヤ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008245852A (ja) * 2007-03-29 2008-10-16 Terumo Corp ガイドワイヤ

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10980968B2 (en) 2008-12-08 2021-04-20 Scientia Vascular, Llc Micro-cutting systems for forming cuts in products
US10232141B2 (en) 2008-12-08 2019-03-19 Scientia Vascular, Llc Micro-cutting systems for forming cuts in products
US10363389B2 (en) 2009-04-03 2019-07-30 Scientia Vascular, Llc Micro-fabricated guidewire devices having varying diameters
US11406791B2 (en) 2009-04-03 2022-08-09 Scientia Vascular, Inc. Micro-fabricated guidewire devices having varying diameters
US9950137B2 (en) 2009-04-03 2018-04-24 Scientia Vascular, Llc Micro-fabricated guidewire devices formed with hybrid materials
US10953203B2 (en) 2016-07-18 2021-03-23 Scientia Vascular, Llc Guidewire devices having shapeable polymer tips
US10953202B2 (en) 2016-07-18 2021-03-23 Scientia Vascular, Llc Guidewire devices having distally extending coils and shapeable tips
US11052228B2 (en) 2016-07-18 2021-07-06 Scientia Vascular, Llc Guidewire devices having shapeable tips and bypass cuts
US11207502B2 (en) 2016-07-18 2021-12-28 Scientia Vascular, Llc Guidewire devices having shapeable tips and bypass cuts
US11890434B2 (en) 2016-07-18 2024-02-06 Scientia Vascular, Inc. Guidewire devices having distally extending coils and shapeable tips
US11951267B2 (en) 2016-07-18 2024-04-09 Scientia Vascular, Inc. Guidewire devices having shapeable tips and bypass cuts
US10821268B2 (en) 2016-09-14 2020-11-03 Scientia Vascular, Llc Integrated coil vascular devices
US11452541B2 (en) 2016-12-22 2022-09-27 Scientia Vascular, Inc. Intravascular device having a selectively deflectable tip
US11369351B2 (en) 2017-05-26 2022-06-28 Scientia Vascular, Inc. Micro-fabricated medical device having a non-helical cut arrangement
US11305095B2 (en) 2018-02-22 2022-04-19 Scientia Vascular, Llc Microfabricated catheter having an intermediate preferred bending section
US12011555B2 (en) 2019-01-15 2024-06-18 Scientia Vascular, Inc. Guidewire with core centering mechanism
CN112587782A (zh) * 2020-12-07 2021-04-02 上海璞慧医疗器械有限公司 一种医用导丝

Similar Documents

Publication Publication Date Title
WO2016047499A1 (fr) Fil-guide
JP5020630B2 (ja) ガイドワイヤ
JP6082807B2 (ja) ガイドワイヤ
JP5148936B2 (ja) ガイドワイヤ
JP2008194185A (ja) ガイドワイヤ
JP2008237253A (ja) ガイドワイヤ
EP2937109A1 (fr) Fil-guide
WO2009119387A1 (fr) Fil-guide et procédé de fabrication correspondant
JP6759069B2 (ja) ガイドワイヤ
JP2015159865A (ja) ガイドワイヤ
EP2982405B1 (fr) Bobine, fil-guide, et procédé de fabrication d'une bobine
JP5473677B2 (ja) ガイドワイヤ
JP2018079246A (ja) ガイドワイヤ
JP6701082B2 (ja) ガイドワイヤおよびガイドワイヤの製造方法
JP2007319705A (ja) ガイドワイヤおよびガイドワイヤの製造方法
JP6306994B2 (ja) ガイドワイヤおよびガイドワイヤの製造方法
JP2013208351A (ja) ガイドワイヤ
JP6155199B2 (ja) ガイドワイヤ
US9808604B2 (en) Guide wire
WO2018034072A1 (fr) Fil-guide
WO2014162389A1 (fr) Fil guide
JP5089517B2 (ja) ガイドワイヤ
JP2013154070A (ja) ガイドワイヤ
WO2014162391A1 (fr) Fil-guide
JP2007307423A (ja) ガイドワイヤ

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15844775

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: JP

122 Ep: pct application non-entry in european phase

Ref document number: 15844775

Country of ref document: EP

Kind code of ref document: A1