WO2016047499A1

WO2016047499A1 - Guide wire

Info

Publication number: WO2016047499A1
Application number: PCT/JP2015/076135
Authority: WO
Inventors: 大秋友
Original assignee: テルモ株式会社
Priority date: 2014-09-26
Filing date: 2015-09-15
Publication date: 2016-03-31

Abstract

This guide wire has an elongated shape and is provided with a core having a small-diameter tip section. In this guide wire, the tip section is a rod-shape that is not flat and has multiple recessed sections that are formed on the outer circumferential section thereof and that are positioned along the central axis direction of the core. The cross-sectional shape of the tip section is circular in locations offset from the areas where the recessed sections are formed. Further, the multiple recessed sections include, in a guide wire side view, first recessed sections that are on the near side from the central axis, and second recessed sections that are on the far side from the central axis, and both the first recessed sections and the second recessed sections are positioned in different locations in the central axis direction.

Description

Guide wire

The present invention relates to a guide wire.

Guidewires can be used to treat difficult-to-surgical sites, such as PTCA (Percutaneous Transluminal Coronary Angioplasty), or for treatment that is minimally invasive to the human body, Used to guide catheters used for examinations such as angiography. A guide wire used for PTCA surgery is inserted to the vicinity of the target vascular stenosis portion together with the balloon catheter with the tip of the guide wire protruding from the tip of the balloon catheter. Guide to near.

The blood vessel is intricately curved, and the guide wire used to insert the balloon catheter into the blood vessel has moderate flexibility and resilience to bending, and pushability to transmit the proximal end operation to the distal end. In addition, torque transmission properties (collectively referred to as “operability”), tensile strength, kink resistance (bending resistance), and the like are required. Among these properties, as a structure for obtaining moderate flexibility and resilience, a structure having a double metal coil having flexibility for bending around a thin tip core material of the guide wire, or a core material of the guide wire Some use super-elastic wires such as Ni-Ti (for example, see Patent Document 1). It is also known that a reinforcing material is separately provided at the tip of the core material in order to improve torque transmission.

In addition, when used in PTCA surgery, the guide wire has been made to reduce the pushability by thinning the tip of the core material so as to avoid the penetration of the blood vessel wall and be used as safely as possible. In order to maintain sufficient tensile strength to avoid breakage, the cross-sectional area should not be reduced excessively. Furthermore, in the PTCA technique, the tip of the core material may be shaped. In order to facilitate this shaping, it is known to press the tip of the core material into a flat plate shape. This reduces the pushability of the tip and improves safety. However, torque transmission performance is remarkably lowered, and when the reinforcing material is provided separately, torque transmission is improved, but it is difficult to perform such shaping.

As described above, with the conventional guide wire, it is difficult to coexist with ease of shaping at the tip and improvement in torque transmission to the tip while maintaining safe pushability and tensile strength. .

US Patent No. 7785274 B2

An object of the present invention is to provide a guide wire that can be easily shaped at the distal end portion of the guide wire and is excellent in torque transmission to the distal end portion.

Such an object is achieved by the present inventions (1) to (9) below.
(1) A guide wire comprising a core wire having a long shape and a thin tip portion,
The guide wire has a rod shape that is not a flat shape, and has a plurality of recesses formed on an outer peripheral portion thereof and disposed along a central axis direction of the core wire.

(2) The guide wire according to (1), wherein the distal end portion has a circular cross-sectional shape at a position displaced from a portion where the concave portion is formed.

(3) The plurality of recesses include a first recess on the near side of the center axis and a second recess on the back side of the center axis in a side view of the guide wire. ,
The guide wire according to (1) or (2), wherein the first recess and the second recess are arranged at different positions in the central axis direction.

(4) The guide wire according to any one of (1) to (3), wherein each of the recesses has a round bottom.

(5) The guide wire according to any one of (1) to (4), wherein a maximum depth of the concave portion is 1% or more and 50% or less of a maximum outer diameter of the outer peripheral portion.

(6) The guide wire according to any one of (1) to (5), wherein each of the recesses is a groove along a circumferential direction of the outer peripheral portion.

(7) The guide wire according to (6), wherein the length of the groove is 10% or more and 75% or less of the entire circumference of the outer peripheral portion.

(8) The guide wire according to any one of (1) to (7), wherein the size of each of the recesses changes along the central axis.

(9) The guide wire according to any one of (1) to (8), wherein an interval between the recesses adjacent in the central axis direction changes along the central axis.

In the guide wire of the present invention, it is preferable that the sizes of the recesses are the same.

According to the present invention, torque can be reliably transmitted to the distal end portion of the guide wire by forming the tip portion of the rod shape which is not a flat shape, that is, excellent torque transmission.

In addition, since the plurality of recesses arranged along the central axis direction of the core wire are formed at the same angle on the outer peripheral portion of the distal end portion, the bending direction at the distal end portion of the guide wire becomes only one direction, and shaping is performed. Becomes easy.

Furthermore, by forming the concave portion by press working, the area decrease in each cross section can be suppressed, so the decrease in tensile strength is reduced.

FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the guide wire of the present invention. FIG. 2 is a view of the core wire (reshaping portion) provided in the guide wire shown in FIG. 1 as viewed from the direction of arrow A in the drawing. FIG. 3 is a perspective view of a core wire (reshaping portion) provided in the guide wire shown in FIG. 4 is a cross-sectional view taken along line BB in FIG. FIG. 5 is a cross-sectional view taken along the line CC in FIG. FIG. 6 is a cross-sectional view of the reshape portion of the core wire provided in the guide wire (second embodiment) of the present invention. FIG. 7 is a cross-sectional view of the reshape part of the core wire provided in the guide wire (second embodiment) of the present invention. FIG. 8 is a plan view of the reshape portion of the core wire provided in the guide wire (third embodiment) of the present invention. FIG. 9 is a plan view of the reshape portion of the core wire provided in the guide wire (fourth embodiment) of the present invention. FIG. 10 is a plan view of the reshape part of the core wire provided in the guide wire (fifth embodiment) of the present invention. FIG. 11 is a plan view of a reshape portion of a core wire included in the guide wire (sixth embodiment) of the present invention.

Hereinafter, the guide wire of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

<First Embodiment>
FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the guide wire of the present invention. FIG. 2 is a view of the core wire (reshaping portion) provided in the guide wire shown in FIG. 1 as viewed from the direction of arrow A in the drawing. FIG. 3 is a perspective view of a core wire (reshaping portion) provided in the guide wire shown in FIG. 4 is a cross-sectional view taken along line BB in FIG. FIG. 5 is a cross-sectional view taken along the line CC in FIG. In the following, for convenience of explanation, the right side in FIGS. 1 to 3 (same as in FIGS. 8 to 11) is referred to as “base end”, and the left side is referred to as “tip”. Also, in FIGS. 1 to 3 (the same applies to FIGS. 8 to 11), for the sake of easy understanding, the length direction of the guide wire is shortened and the thickness direction of the guide wire is exaggerated and schematically illustrated. The ratio between the length direction and the thickness direction is very different from the actual one.

A guide wire 1 shown in FIG. 1 is a guide wire for a catheter that is used by being inserted into the lumen of a catheter (including an endoscope) by PTCA, for example. The total length of the guide wire 1 is not particularly limited, but is preferably about 200 to 5000 mm. The guide wire 1 includes a core wire (wire body) 2 composed of a single long wire, and a spiral coil 5 installed at the tip end portion (tip end portion) of the core wire 2. ing.

The core wire 2 includes a reshape portion 3 located on the distal end side and a main body portion 4 located on the proximal end side of the reshape portion 3.

The reshape portion 3 is a portion that is located at the tip of the core wire 2 and can be reshaped (shaped) with a small diameter. For example, the reshape portion 3 is bent or curved in the arrow direction in FIG. 1 so as to be deformed into a desired shape. Can be used. In general, in order to guide the distal end of a guide catheter or the like to a blood vessel shape, or to select and guide a blood vessel branch appropriately and smoothly, a doctor or the like previously sets the distal end of the guide wire to a desired shape. In this way, bending the tip of the guide wire into a desired shape is called reshaping. And by providing the reshape part 3, reshape can be performed easily and reliably, and the operativity at the time of inserting the guide wire 1 in a biological body improves markedly. In addition, the marker which shows the preferable bending direction of the said front-end | tip part may be attached | subjected to the front-end | tip part of the guide wire 1. FIG.

The main body 4 is a thicker and longer part than the reshape part 3. The main body portion 4 has a tapered portion 41 having a tapered shape in which the outer diameter gradually increases in the proximal direction, and a constant outer diameter portion 42 having a constant outer diameter.

By forming the taper portion 41 between the reshape portion 3 and the constant outer diameter portion 42, the rigidity (bending rigidity, torsional rigidity) of the core wire 2 can be gradually reduced toward the distal end. As a result, the guide wire 1 can obtain a good stenosis portion passing through and flexibility at the distal end portion, improve followability to a blood vessel and the like, and can be prevented from being bent. In addition, the taper angle (decrease rate of the outer diameter) of the taper portion 41 may be constant along the longitudinal direction of the core wire 2 or may have a portion that varies along the longitudinal direction. For example, a portion where a relatively large taper angle and a relatively small portion are alternately formed a plurality of times may be used.

The outer diameter constant portion 42 has the same outer diameter as the maximum outer diameter of the tapered portion 41, and is a portion having relatively high rigidity. Thereby, the pushing property to the front-end | tip direction of the guide wire 1 becomes favorable. The base end surface 421 of the constant outer diameter portion 42 is preferably rounded.

As shown in FIG. 1, a coil 5 is disposed on the outer periphery of the reshape portion 3 of the core wire 2 so as to cover the reshape portion 3. The coil 5 reduces the contact area of the surface of the core wire 2 with the inner wall of the catheter or the surface of the living body, thereby reducing sliding resistance, and as a result, the operability of the guide wire 1 is further improved.

The reshape portion 3 is inserted through the central portion inside the coil 5, and the reshape portion 3 is not in contact with the inner surface of the coil 5. As a result, a gap 11 is formed between the coil 5 and the reshapable portion 3, and the pushability with respect to the blood vessel wall can be lowered.

The coil 5 is formed by winding a wire 51 in a spiral shape along the circumferential direction of the reshapable portion 3. In this case, one strand 51 may be spirally wound, or a plurality of strands 51 may be spirally wound.

In this embodiment, the adjacent strands 51 of the coil 5 are in contact with each other and are in a so-called densely wound state. These strands 51 generate a force (compression force) that pushes them in the axial direction of the core wire 2 in a natural state where no external force is applied. The guide wire 1 is not limited to this, and there may be a so-called sparsely wound portion where the adjacent strands 51 of the coil 5 are separated from each other.

The constituent material of the strand 51 is not particularly limited, and may be either a metal material or a resin material. Preferable examples of the metal material include X-ray opaque materials such as stainless steel, noble metals such as Au and Pt, and alloys containing the noble metals (for example, Pt—Ni alloys). When an X-ray opaque material is used, X-ray contrast properties are obtained at the distal end portion of the guide wire 1, and it can be inserted into the living body while confirming the position of the distal end portion under X-ray fluoroscopy.

The coil 5 may be a combination of two or more materials. For example, the strand 51 on the distal end side of the coil 5 can be made of an X-ray opaque material such as the Pt—Ni alloy, and the strand 51 on the proximal end side of the coil 5 can be made of stainless steel. In this case, under X-ray fluoroscopy, the part located on the distal end side of the coil 5 (particularly, the part including the reshapable portion 3) can be emphasized more than the part located closer to the proximal end ( Therefore, the position of the most distal portion (the portion where the reshape portion 3 exists) of the guide wire 1 can be visually recognized more clearly.

The wire diameter of the strand 51 of the coil 5 may be the same over the entire length of the coil 5, but the wire diameter of the strand 51 may be different between the distal end side and the proximal end side of the coil 5. For example, the wire diameter of the strand 51 may be smaller (or larger) on the distal end side of the coil 5 than on the proximal end side. Thereby, the softness | flexibility of the guide wire 1 in the front-end | tip part of the coil 5 can be improved more.

Further, the outer diameter of the coil 5 may be the same over the entire length of the coil 5, but the outer diameter of the coil 5 may be different between the distal end side and the proximal end side of the coil 5. For example, the outer diameter of the coil 5 may be smaller on the distal end side of the coil 5 than on the proximal end side. Thereby, the penetration of the lesioned part of the guide wire 1 at the distal end of the coil 5 can be further improved.

As shown in FIG. 1, the coil 5 is fixed to the core wire 2 at two locations. That is, the distal end portion of the coil 5 is fixed to the distal end of the reshapable portion 3 via a fixing material (fixing portion) 52, and the proximal end portion of the coil 5 is located in the middle of the tapered portion 41 via the fixing material (fixing portion) 53. It is fixed. By fixing at a plurality of locations in this way, the coil 5 can be securely fixed to the core wire 2 while preventing the tip portion of the guide wire 1 (the portion where the coil 5 is present) from being impaired. it can.

In particular, since the distal end side and the proximal end side of the reshape portion 3 are fixed by the fixing

materials

52 and 53, respectively, the reshape portion 3 can be securely fixed to the coil 5, and the shape of the shaped reshape portion 3 can be secured. Can be held properly.

Each of the fixing

materials

52 and 53 is preferably made of solder (brazing material). In addition, the fixing

materials

52 and 53 may be adhesives. Further, the method for fixing the coil 5 to the core wire 2 is not limited to the above-described fixing material, and for example, welding may be used.

In addition, in order to prevent damage to the inner wall of a body cavity such as a blood vessel, the distal end surface 521 of the fixing material 52 is preferably rounded.

As shown in FIG. 1, a resin coating layer 6 that covers the whole (or a part) of the core wire 2 is provided on the proximal end side of the fixing material 53 of the core wire 2. The resin coating layer 6 can be formed for various purposes. As an example, the operability of the guide wire 1 is reduced by reducing the friction (sliding resistance) of the guide wire 1 and improving the slidability. May be improved.

In order to reduce the friction (sliding resistance) of the guide wire 1, the resin coating layer 6 is preferably made of a material that can reduce friction as described below. Thereby, the frictional resistance (sliding resistance) with the inner wall of the catheter used together with the guide wire 1 is reduced, the slidability is improved, and the operability of the guide wire 1 in the catheter becomes better. Further, since the sliding resistance of the guide wire 1 is lowered, the guide wire 1 can be reliably prevented from being kinked (bent) or twisted when the guide wire 1 is moved and / or rotated in the catheter.

Examples of materials that can reduce such friction include polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polyesters (PET, PBT, etc.), polyamides, polyimides, polyurethanes, polystyrenes, polycarbonates, silicone resins, fluorine resins ( PTFE, ETFE, etc.) or a composite material thereof.

The resin coating layer 6 may be a single layer or a laminate of two or more layers (for example, an inner layer made of a material that is more flexible than an outer layer).

Now, as shown in FIG. 1, in the guide wire 1, the reshape portion 3 is disposed at the most distal end portion of the core wire 2, and the reshape portion 3 is formed integrally with the main body portion 4. Thus, since each part which comprises the core wire 2 is formed integrally, manufacture of the core wire 2 (guide wire 1) becomes easy.

The constituent material of the core wire 2 is not particularly limited. For example, stainless steel (for example, SUS304, SUS303, SUS316, SUS316L, SUS316J1, SUS316J1L, SUS405, SUS430, SUS434, SUS444, SUS429, SUS430F, SUS302, and all other types of SUS. ), Various metal materials such as piano wire can be used, and among these, stainless steel is preferable.

Further, in addition to a material having relatively high rigidity such as stainless steel, a superelastic alloy exhibiting superelasticity in vivo can be used as a constituent material of the core wire 2. Superelastic alloys include any shape of stress-strain curve caused by tension, including those where the transformation point of As, Af, Ms, Mf, etc. can be measured remarkably, and those that cannot be deformed. However, everything that returns to its original shape by removing stress is included. The preferred composition of the superelastic alloy is a Ni—Ti alloy such as a Ni—Ti alloy of 49 to 52 atomic% Ni, a Cu—Zn alloy of 38.5 to 41.5 wt% Zn, 1 to 10 wt% X Cu—Zn—X alloy (X is at least one of Be, Si, Sn, Al, and Ga), Ni-Al alloy of 36 to 38 atomic% Al, and the like. Of these, the Ni—Ti alloy is particularly preferable. When the core wire 2 is made of a superelastic alloy, heat treatment is performed on the portion of the core wire 2 that is to be the reshaped portion 3. Thereby, the physical property in the said part changes, ie, superelasticity reduces or lose | disappears, and the reshape part 3 which can be reshaped can be provided. In addition to the heat treatment, the portion may be cold worked. In addition, a superelastic alloy typified by a Ni—Ti alloy is excellent in adhesion to the resin coating layer 6.

As shown in FIGS. 1 to 3, the reshapable portion 3 is not flat, that is, in the present embodiment, there are a plurality of circular cross-sectional portions 31 (14 in the configuration shown in FIG. 1) having a circular cross-sectional shape. However, it is a rod-shaped part. These circular cross-sections 31 are intermittently arranged along the central axis O ₂ of the core wire 2. And in the outer peripheral part between adjacent circular cross-section parts 31, the 1st recessed part (1st defect | deletion part) 32 or the 2nd recessed part (2nd defect | deletion part) 33 is formed 1 each. . Each recess can be processed by, for example, press molding.

These concave portions are arranged at equal intervals on the straight line along the central axis O ₂ direction in both the first concave portion 32 and the second concave portion 33, but are different from each other in the central axis O ₂ direction. In other words, the first recesses 32 and the second recesses 33 are alternately arranged so as not to overlap in the side view of the guide wire 1 (hereinafter, this arrangement relationship is referred to as “alternate arrangement”. Say). Therefore, as shown in FIG. 2, the first recess 32 is located on the front side (the front side of the drawing) from the center axis O ₂ and the second recess 33 is the center axis O _{2 as} viewed from the side of the guide wire 1. It will be in the state located in the back side (paper surface back side).

Here, suppose that the reshape portion 3 has a flat shape, that is, a flat plate shape (ribbon shape), and the thickness thereof is smaller than the outer diameter (maximum outer diameter) φd _{31 of the} circular cross section 31. . In this case, the reshapable portion 3 can be easily bent and reshapable, but the torque transmission at the reshapable portion 3 may be significantly reduced. Therefore, for example, even if a torque is applied to the guide wire from the proximal end side so that the distal end portion of the guide wire passes through a stenosis portion (lesioned portion) in the blood vessel, the distal end portion does not rotate 1: 1. As a result, it may be difficult to pass through the constriction. In addition, a minute force applied to the distal end portion of the guide wire 1 by the narrowed portion (distal end portion) is not transmitted to the proximal end portion of the guide wire 1 and it becomes difficult to obtain information such as the hardness of the narrowed portion.

Therefore, as described above, reshapable portion 3 is not a flat shape, and is intended to round sectional portions 31 is intermittently disposed along the central axis O _2. As a result, the reshapable portion 3 as a whole becomes so-called firm, that is, the torsional rigidity is increased and the torque transmission is improved.

As shown in FIGS. 4 and 5, the cross-sectional shape of the portion of the reshapable portion 3 where the first concave portion 32 and the second concave portion 33 are formed (hereinafter referred to as “non-circular cross-sectional portion 34”) is The shape is such that part of the circle is missing. Therefore, the width in the pressing direction of the non-circular cross section 34 is smaller than the thickness of the circular cross section 31. As a result, when the reshaped portion 3 is reshaped into a desired shape, each non-circular cross-sectional portion 34 can be preferentially deformed over each circular cross-sectional portion 31, and thus the shape of the reshaped portion 3. The attachment can be easily and reliably performed in one direction along the non-circular cross section 34, and the shape is maintained.

As described above, the guide wire 1 can be easily shaped at the tip, that is, the reshape portion 3, and has excellent torque transmission to the reshape portion 3.

As described above, the first recesses 32 and the second recesses 33 are arranged alternately. Thereby, since the circular cross-sectional part 31 remains reliably (formed) between the 1st recessed part 32 and the 2nd recessed part 33, the fall of torque performance can be suppressed.

If the first recess 32 and the second recess 33 are arranged so as to overlap in a side view of the guide wire 1, the cross-sectional area of the reshape portion 3 at that portion (noncircular cross-sectional portion 34) is extremely large. The tensile strength is greatly reduced. Moreover, the shape maintenance property (limit load) after shaping (after reshaping) is reduced. However, the alternating arrangement can prevent the thickness of the reshapable portion 3 from becoming extremely thin, thereby preventing a decrease in tensile strength and shape maintainability.

As shown in FIGS. 4 and 5 (the same applies to FIGS. 1 to 3), the first recess 32 and the second recess 33 have the same size. The maximum depth u of each recess is preferably 1% or more and 50% or less of the outer diameter φd ₃₁ (maximum outer diameter of the outer peripheral portion of the reshapable part 3) of the circular cross-section 31, preferably 5% or more. More preferably, it is 20% or less. The width w of each recess is preferably 1% or more and 200% or less, and 50% or more and 100% or less of the outer diameter φd ₃₁ of the circular cross-section 31 (the maximum outer diameter of the outer peripheral portion of the reshapable part 3). More preferably. Due to such a magnitude relationship, for example, the ease of bending is the same when the reshapable portion is bent upward in FIG. 1 and when the reshapable portion is bent downward, thereby improving operability during reshaping.

As shown in FIG. 3, the bottom 321 of the first recess 32 is rounded in an arc shape, and the bottom 331 of the second recess 33 is also rounded in an arc shape. Thereby, when reshaping, stress concentration near the bottom 321 and the bottom 331 can be reduced or prevented.

Second Embodiment
6 and 7 are cross-sectional views of the reshape portion of the core wire provided in the guide wire (second embodiment) of the present invention (the positions of the cross-section in FIG. 6 and the cross-section in FIG. 7 are respectively , Different in the longitudinal direction of the reshapable part).

Hereinafter, the second embodiment of the guide wire of the present invention will be described with reference to these drawings, but the description will focus on the differences from the above-described embodiment, and the description of the same matters will be omitted.
This embodiment is the same as the first embodiment except that the shape of the recess is different.

As shown in FIGS. 6 and 7, in the present embodiment, the first recess 32 and the second recess 33 are each configured by a groove along the circumferential direction of the outer peripheral portion of the reshapable portion 3. The length _{L 1} of each groove, 10% or more of the total circumference _{L 2} of the outer peripheral portion of the reshapable portion 3, but preferably not more than 75%, 15% or more, more preferably 60% or less.

The formation of the first concave portion 32 and the second concave portion 33 having such a shape can prevent the torque transmission at the reshape portion 3 from being lowered.

<Third Embodiment>
FIG. 8 is a plan view of the reshape portion of the core wire provided in the guide wire (third embodiment) of the present invention.

Hereinafter, the third embodiment of the guide wire of the present invention will be described with reference to this figure, but the description will focus on the differences from the above-described embodiment, and the description of the same matters will be omitted.
This embodiment is the same as the first embodiment except that the arrangement state of the recesses is different.

As shown in FIG. 8, a first recess 32 intervals adjacent to the central axis O ₂ direction, it varies along the central axis O _2. That is, in this embodiment, the first recess 32 the distance between the centers of adjacent to the center axis O ₂ direction (pitch) p ₃₂ are gradually decreased along the distal direction.

Similarly, the interval between the second recess 33 adjacent to the central axis O ₂ direction, varies along the central axis O _2. That is, in this embodiment, distance between centers of the second recess 33 adjacent to the central axis O ₂ direction (pitch) p ₃₃ also gradually decreases along the distal direction.

With such a configuration, the rigidity (bending rigidity) of the reshape part 3 as a whole can be gradually reduced in the distal direction. Therefore, in the reshape part 3, the distal end portion is the proximal end portion. It becomes easier to bend than. This configuration is effective when the reshapable portion 3 is changing in bendability, that is, when it is desired to gradually increase or decrease the size (strength).

<Fourth embodiment>
FIG. 9 is a plan view of the reshape portion of the core wire provided in the guide wire (fourth embodiment) of the present invention.

Hereinafter, the guide wire according to the fourth embodiment of the present invention will be described with reference to the drawings. However, the difference from the above-described embodiment will be mainly described, and the description of the same matters will be omitted.
This embodiment is the same as the first embodiment except that the arrangement state of the recesses is different.

As shown in FIG. 9, the first recess 32 intervals adjacent to the central axis O ₂ direction, it varies along the central axis O _2. That is, in the present embodiment, the center-to-center distance (pitch) p ₃₂ between the first recesses 32 adjacent in the direction of the central axis O ₂ gradually decreases toward the base end direction.

Similarly, the interval between the second recess 33 adjacent to the central axis O ₂ direction, varies along the central axis O _2. That is, in this embodiment, distance between centers of the second recess 33 adjacent to the central axis O ₂ direction (pitch) p ₃₃ also gradually decreases along the proximal direction.

With such a configuration, the rigidity (bending rigidity) of the reshape part 3 as a whole can be gradually decreased in the proximal direction. Therefore, in the reshape part 3, the proximal side part is the distal side part. It becomes easier to bend than the part. This configuration is effective when the reshapable portion 3 is changing in bendability, that is, when it is desired to gradually increase or decrease the size (strength).

<Fifth Embodiment>
FIG. 10 is a plan view of the reshape part of the core wire provided in the guide wire (fifth embodiment) of the present invention.

Hereinafter, the fifth embodiment of the guide wire of the present invention will be described with reference to this drawing. However, the description will focus on the differences from the above-described embodiment, and the description of the same matters will be omitted.
This embodiment is the same as the first embodiment except that the size of the recesses is different.

As shown in FIG. 10, in the present embodiment, one of the first recess 32 and the second recess 33 (the second recess 33 in the present embodiment) is omitted. The size of each first recess 32 is changed in accordance along the central axis O _2. That is, in the present embodiment, the width w of each first recess 32 gradually increases toward the proximal direction. The maximum depth u of each first recess 32 is the same, but the curvature R of the bottom 321 is different, that is, gradually decreases toward the proximal direction.

<Sixth Embodiment>
FIG. 11 is a plan view of a reshape portion of a core wire included in the guide wire (sixth embodiment) of the present invention.

Hereinafter, the sixth embodiment of the guide wire according to the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and the description of the same matters will be omitted.
This embodiment is the same as the first embodiment except that the size of the recesses is different.

As shown in FIG. 11, in the present embodiment, one of the first recess 32 and the second recess 33 (the second recess 33 in the present embodiment) is omitted. The size of each first recess 32 is changed in accordance along the central axis O _2. That is, in the present embodiment, the width w of each first recess 32 gradually increases toward the distal end. The maximum depth u of each first recess 32 is the same, but the curvature R of the bottom 321 is different, that is, gradually decreases toward the tip.

As mentioned above, although the guide wire of this invention was demonstrated about embodiment of illustration, this invention is not limited to this, Each part which comprises a guide wire is a thing of arbitrary structures which can exhibit the same function. Can be substituted. Moreover, arbitrary components may be added.

Further, the guide wire of the present invention may be a combination of any two or more configurations (features) of the above embodiments.

The guide wire of the present invention is a guide wire having a long shape and a core wire having a thin tip portion, and the tip portion is formed in a rod shape that is not a flat shape, and is formed on the outer peripheral portion of the guide wire. It has a plurality of recesses arranged along the central axis direction. Therefore, it is easy to shape the tip of the guide wire, and the torque transmission to the tip is excellent.

1 Guide wire 11 Gap 2 Core wire (Wire body)
3 Reshape part 31 Circular cross-sectional part 32 1st recessed part (1st defect | deletion part)
321 bottom 33 second recess (second defect)
331 Bottom portion 34 Non-circular cross section 4 Body portion 41 Taper portion 42 Constant outer diameter portion 421 Base end surface 5 Coil 51

Wire

52, 53 Fixing material (fixing portion)
521 Tip surface 6 Resin coating layer φd ₃₁ outer diameter (maximum outer diameter)
L ₁ length L ₂ full circumference O ₂ center axis p ₃₂ , p ₃₃ center distance (pitch)
R Curvature u Maximum depth w Width

Claims

A guide wire comprising a core wire having an elongated shape and a thin tip portion,
The guide wire has a rod shape that is not a flat shape, and has a plurality of recesses formed on an outer peripheral portion thereof and disposed along a central axis direction of the core wire.
The guide wire according to claim 1, wherein the distal end portion has a circular cross-sectional shape at a position shifted from a portion where the concave portion is formed.
The plurality of recesses include a first recess on the nearer side than the central axis and a second recess on the farther side than the central axis in a side view of the guide wire,
The guide wire according to claim 1 or 2, wherein the first recess and the second recess are arranged at different positions in the central axis direction.
The guide wire according to any one of claims 1 to 3, wherein each of the recesses has a round bottom.
The guide wire according to any one of claims 1 to 4, wherein a maximum depth of the concave portion is 1% or more and 50% or less of a maximum outer diameter of the outer peripheral portion.
The guide wire according to any one of claims 1 to 5, wherein each of the concave portions is a groove along a circumferential direction of the outer peripheral portion.
The guide wire according to claim 6, wherein the length of the groove is 10% or more and 75% or less of the entire circumference of the outer peripheral portion.
The guide wire according to any one of claims 1 to 7, wherein the size of each of the recesses changes along the central axis.
The guide wire according to any one of claims 1 to 8, wherein an interval between recesses adjacent to each other in the central axis direction changes along the central axis.