WO2015155639A1 - Mélange d'agarose de type gel pour obtenir un produit cosmétique intermédiaire - Google Patents
Mélange d'agarose de type gel pour obtenir un produit cosmétique intermédiaire Download PDFInfo
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- WO2015155639A1 WO2015155639A1 PCT/IB2015/052406 IB2015052406W WO2015155639A1 WO 2015155639 A1 WO2015155639 A1 WO 2015155639A1 IB 2015052406 W IB2015052406 W IB 2015052406W WO 2015155639 A1 WO2015155639 A1 WO 2015155639A1
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- WIPO (PCT)
- Prior art keywords
- agarose
- oil
- vitamin
- admixture
- aqueous solution
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 230000011987 methylation Effects 0.000 description 2
- 238000007069 methylation reaction Methods 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910021653 sulphate ion Inorganic materials 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 2
- 239000010497 wheat germ oil Substances 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical group CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- 229920001938 Vegetable gum Polymers 0.000 description 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 description 1
- 125000005197 alkyl carbonyloxy alkyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 238000013142 basic testing Methods 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 239000012501 chromatography medium Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N glyceric acid Chemical compound OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
- A61Q1/06—Lipsticks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Definitions
- the present invention pertains to a method and composition of a gel-like agarose admixture useful for cosmetics applications, more specifically this invention provides a gel-like agarose admixture as an intermediate cosmetics product.
- cosmetic bases are known for use in cosmetic compositions, such as liquids, creams, gels and lotions.
- these cosmetic bases are formed as emulsions (e.g., water-in- oil, oil-in-water, triple emulsions, microemulsions) to permit the delivery of water and oils to the skin, hair, nails or other surface to be treated.
- Polysaccharides such as agaroses are widely used materials in the life science and biology fields. They can be used as substrates for electrophoresis or as a capture or chromatography media, either directly as a size exclusion material or through the bonding of various capture ligands, such as Protein A to their surfaces or pores.
- Agarose also can have high gel strength at low concentration, thus providing gel networks with high water content.
- the natural agarose polymer contains charged groups, such as pyruvate and sulphate.
- the agarose polysaccharide also contains uncharged methyl groups.
- the extent of natural methylation is directly proportional to the gelling temperature.
- synthetically methylated agaroses have lower, rather than higher, gelling temperatures, and the degree of synthetic methylation is inversely proportional to the melting temperature.
- the natural polymer is modified in order to obtain agarose with different melting and gelling temperatures.
- the sulphate and pyruvate groups are reduced in order to obtain uncharged polymer.
- the charged groups can be substituted with hydroxyethyl or vinyl (allyl) groups to the various extents in order to obtain agarose with low melting temperature. Therefore, there is long felt and unmet need to provide agarose based suspensions having an improved texture and more pleasant skin feel .
- the admixture characterized by a cross-linked network of agarose-agarose comprising the hydrophobic substance intercalated within the cross-linked network of the agarose-agarose. It is another object of the present invention to provide a gel-like agarose admixture useful for cosmetics applications, comprising a hydrophobic substance and aqueous solution of agarose; wherein the hydrophobic substance is admixed with the aqueous solution of agarose in a functionalized cross-linked network ; further wherein when the hydrophobic substance and the aqueous solution of agarose is heated to a temperature range of about 50-70°C the hydrophobic substance is suspended in a network of the aqueous agarose .
- the gel-like admixture additionally comprising at least one ingredient selected from the group consisting of emulsifiers, emollients, thickeners, preservatives, humectants, consistency factors, antioxidants, UV blockers, vitamins, antioxidants, chelating agents, fragrance, active agents, plant extracts, coloring agents, aesthetics enhancers, vegetable oils, animal oils and fats, minerals, proteins, seaweed extracts, and any combination thereof.
- Johnswort stem cells, sugar cane juice, sunflower oil, sweet almond oil, sweet orange oil, tea tree, thyme, tocopherol, tocopheryl acetate, tribehenin, turmeric ubiquinone, ulva lactuca ,vanilla, vitamin A, vitamin B complex, vitamin B factor (Inositol), vitamin B factor (Niacin B3), vitamin C (ascorbic acid), vitamin C (citric acid), vitamin C (ester C), vitamin C (L-ascorbic acid), vitamin C (magnesium ascorbyl phosphate), vitamin D , vitamin E (tocopherol), vitamin E (d-alpha tocopherol), vitamin E (tocopheryl acetate), walnut extract, walnut powder, watercress, wheat germ, wheat protein, white tea, wild thyme, wild yam root, willow bark, witch hazel, xanthan gum, ylang ylang, yucca extract, zingiber zerumbet, zinigiber officinal
- the method additionally comprising step of heating the aqueous solution of agarose with the hydrophobic substance to a temperature in the range of about 50-70°C thereby forming a cross-linked network of agarose-agarose comprising the hydrophobic substance intercalated within the cross-linked network of the agarose-agarose.
- the method additionally comprising step admixing at least one ingredient to produce the gellike agarose admixture selected from the group consisting of emulsifiers, emollients, thickeners, preservatives, humectants, consistency factors, antioxidants, UV blockers, vitamins, antioxidants, chelating agents, fragrance, active agents, plant extracts, coloring agents, aesthetics enhancers, vegetable oils, animal oils and fats, minerals,
- Johnswort stem cells, sugar cane juice, sunflower oil, sweet almond oil, sweet orange oil, tea tree, thyme, tocopherol, tocopheryl acetate, tribehenin, turmeric ubiquinone, ulva lactuca ,vanilla, vitamin A, vitamin B complex, vitamin B factor (Inositol), vitamin B factor (Niacin B3), vitamin C (ascorbic acid), vitamin C (citric acid), vitamin C (ester C), vitamin C (L-ascorbic acid), vitamin C (magnesium ascorbyl phosphate), vitamin D , vitamin E (tocopherol), vitamin E (d-alpha tocopherol), vitamin E (tocopheryl acetate), walnut extract, walnut powder, watercress, wheat germ, wheat protein, white tea, wild thyme, wild yam root, willow bark, witch hazel, xanthan gum, ylang ylang, yucca extract, zingiber zerumbet, zinigiber officinal
- Fig. 1 illustrates a flow chart of a method of preparing a gel-like agarose admixture of the present invention.
- the present invention provides a unique agarose cosmetic composition or vehicle having improved properties for cosmetics applications comprising aqueous solution of agarose and a hydrophobic substance.
- the agarose in water solution and the hydrophobic substance are admixed to form an agarose gel-like admixture or matrix having an improved texture and more pleasant skin feel.
- the agarose gel-like admixture is provided as an intermediate cosmetics product for skin, hair, nails or other surfaces to be treated.
- the term "cosmetic" is as defined under the Federal Food, Drug, and Cosmetic Actl sec. 201 (i) as articles intended to be rubbed, poured, sprinkled, or sprayed on, introduced into, or otherwise applied to the human body for cleansing, beautifying, promoting attractiveness, repeating or altering the appearance of the cosmetic composition.
- X refers to a range 25% less than to 25% more than of X (X + 25%), at times X + 20%, X + 15% and preferably X + 10.
- the present invention provides a gel-like agarose admixture comprising an aqueous solution of agarose as a continuous phase and a hydrophobic substance as a dispersed phase.
- the aqueous solution of agarose comprises agarose particles mixed with the hydrophobic substance e.g a water immiscible phase forming a gel-like agarose three-dimensional cross- linked network comprising a hydrophobic substance intercalated within the cross-linked network of agarose-agarose.
- the cross-linked network structure reduces the intrastrand hydrogen bonds, resulting in lower melting and setting temperature than standard agaroses, thereby forming oil droplets in between the network of the agarose bonds.
- the entire system is cooled below the gel point of agarose and the oil droplets trapped in between the network of the agarose hydrogen bonds forms the gellike agarose admixture.
- the gel-like agarose admixture is a dispersion of molecules of a liquid within a solid in which the solid is the continuous phase and the liquid is the discontinuous phase.
- the gel-like agarose admixture comprises an agarose polymer in water resulting a solution of about 95-99.9 wt % of water and more preferably approximately 98-99.9%wt of water, thereby imparting skin feel to cosmetics products.
- This matrix functions like an emulsion to deliver water and oil to the skin, hair, nails or other surface to be treated.
- the present invention further provides a method for preparing a gel-like agarose admixture useful for cosmetics applications.
- Reference in now made to Figure 1 which presents a flow chart of the method for preparing a gel-like agarose admixture useful for cosmetics applications.
- the gel-like agarose admixture is prepared by the following steps:
- admixture is not homogeneous thus the admixture is not uniform, in one color or in the same form , additional amount of agarose solution droplets or water-immiscible/oil phase droplets, based on the amount of agarose solution, is admixed to the continues phase respectively , according to the steps described in step iv.
- the admixture is further evaluated and when a desired gel shape physical appearance (e.g viscosity) and visual appearance are achieved the mixture is cooled down to a room temperature forming a gel-like agarose admixture.
- the hardness and the transparent of the agarose gel-like cosmetic admixture of the present invention can be adjusted by altering the blend amount of the water- immiscible/oil phase or the aqueous solution of agarose, respectively
- the aqueous solution of agarose may comprise different types of agarose such as natural agarose, reduced agarose or a substituted agarose with low melting temperature.
- the substituents is selected from the group consisting of hydroxyethyl, hydroxypropyl, methyl, allyl ,acetyl substituents and any mixture thereof.
- the aqueous solution of agarose is heated to temperature depends on the agarose concentration and the agarose type.
- the agarose concentration is at least of about 0.1 wt %.
- the agarose is preferably with a molecular weight of about 10,000 to about 1,500,000 daltons.
- the rupture strength or hardness properties of the agarose gel-like admixture may be measured according to the following procedure:
- the cosmetic transparent gel preparation was left to stand for one hour at 20°C, and then using a Rheometer , a plunger with a diameter of 3 mm may be used to press the sample at a mounting rate of 60 mm/minute, and the maximum stress value is measured and recorded as the rupture strength.
- the transparency of the agarose gel-like admixture may be evaluated based on the ease of readability of a hiragana character "a" (size of character: 1 cm square) positioned 0.5 cm behind a glass bottle containing the sample, when viewed through the bottle.
- the evaluation criteria for the transparency are listed below. A: the character can be read clearly B: the character appears clouded, but can be read
- the Usability of the agarose gel-like admixture may be evaluated as followed: the sample was poured into a mold to prepare a stick-type cosmetic preparation, and following application of the preparation to the lips, the degree of disintegration at the application surface of the stick was evaluated.
- the evaluation criteria are listed below:
- the gel rigidity may be measured and determined according to Shore Durometer Hardness scale.
- Durometer measures the depth of an indentation in the material created by a given force on a standardized presser foot. This depth is dependent on the hardness of the material, its viscoelastic properties, the shape of the presser foot, and the duration of the test.
- ASTM D2240 durometers allows for a measurement of the initial hardness, or the indentation hardness after a given period of time. The basic test requires applying the force in a consistent manner, without shock, and measuring the hardness (depth of the indentation). If a timed hardness is desired, force is applied for the required time and then read.
- the material under test should be a minimum of 6.4 mm
- Table 1 below presents the ASTM D2240 standard which recognizes twelve different durometer scales using combinations of specific spring forces and indentor configurations. These scales are properly referred to as durometer types; i.e., a durometer type is specifically designed to determine a specific scale, and the scale does not exist separately from the durometer. The table below provides details for each of these types, with the exception of Type R.
- the hydrophobic substance is selected from the group consisting of esters of the formula RCO-OR' wherein R and R' are each independently a Ci_ 2 5, preferably a C 4 _ 2 o straight or branched alkyl, alkenyl ,alkoxycarbonylalkyl ,alkylcarbonyloxyalkyl chains any any combination thereof.
- the oil phase can be comprised of tri, di, and mono-glycerides of fatty acids.
- the water phase with the the dissolved agarose is added to the hydrophobic substance as a water-immiscible phase in small portions under vigorous stirring in order to obtain a gel texture.
- the volume ratio of the water phase to the water-immiscible phase is between40:60, and more specifically between 30:70, respectively.
- the volume ratio of the water-immiscible phase to the agarose-water phase may further be in the range of about 0.01% of water-immiscible phase and 99.9% of agarose-water phase, respectively.
- the agarose solution forms aqueous droplets within the water- immiscible phase under vigorous stirring.
- the present invention further provides the step of adding water to the hydrophobic phase under vigorous stirring at 2000 rmp; this particular stirring rate produces particles with diameter of 20-50 ⁇ . In different embodiments of the present invention the particle diameter is smaller than 100 ⁇ .
- the hydrophobic substance as a water- immiscible phase is added to the the water phase with the dissolved agarose in small portions under vigorous stirring in order to obtain a gel texture.
- the volume ratio of the water- immiscible phase to the agarose-water phase is between 40:60, and more specifically between 30:70 respectively.
- the volume ratio of the water-immiscible phase to the agarose-water phase may further be in the range of about 0.01% of water-immiscible phase and 99.9% of agarose-water phase respectively .
- the agarose solution forms aqueous droplets within the water-immiscible phase under vigorous stirring.
- the present invention further provides the step of adding water to the hydrophobic phase under vigorous stirring at 2000 rmp, this particular stirring rate produces particles with diameter of 20-50 ⁇ . In different embodiments of the present invention the particle diameter is smaller than about 100 ⁇ .
- the gel-like agarose admixture may further comprises a thickening agent selected from the group consisting of polyethylene glycol (PEG), synthetic polymers such as carbomer, vegetable gums, various waxes, petroleum jelly and a mixture thereof.
- PEG 1500 is preferably added as a thickening agent.
- the hydrophobic substance may be oil substance selected from the group consisting of natural plant oils such as sweet almond oil, wheat germ oil, and pomegranate oil and any combination thereof.
- the the hydrophobic substance may further comprise additional triglycerides and surfactants.
- the hydrophobic s substance may comprise a mixture of shea butter and almond oil.
- the thickening agent is substituted for a co-solvent such as propylene glycol in order to dissolve shea butter in almond oil.
- the co-solvents may be glycerin, isododecane, octyldodecanol or any other co-solvents that is commonly used in cosmetics products.
- the hydrophobic substance may further comprise a oil emulsifier selected from the group consisting of sorbitan sequiolate, glycerol ether polymer, polyethylene glycol hydrogenated castor oil, sorbitan trioleate, sorbitan monooleate, sorbitan tristearate ,lipophilic-hydrophilic block polymers and a mixture thereof.
- a oil emulsifier selected from the group consisting of sorbitan sequiolate, glycerol ether polymer, polyethylene glycol hydrogenated castor oil, sorbitan trioleate, sorbitan monooleate, sorbitan tristearate ,lipophilic-hydrophilic block polymers and a mixture thereof.
- the emulsion can be passed through a hydrophobic microporous membrane by applying high pressure. The emulsion can be transferred through the membrane at a relatively high flow rate.
- the membrane may be a glass membrane, which has been rendered hydrophobic by the chemical treatment according to the well-
- the membrane is manufactured from an inherently hydrophobic material.
- hydrophobic means that the membrane has sufficient hydrophobicity to allow passage of agarose droplets.
- the membrane can have any type of pore structure such as a network pores or straight cylindrical pores perpendicular to the membrane surface.
- the shape of the membrane can be tubular, hollow fiber, flat sheet or pleated sheet.
- step (vi) emulsion temperature must be lowered slowly at the rate below 2 °C/min under slow stirring (50-200 rpm), such that agarose-in-water droplets are solidified into agarose-in- water gel particles.
- adding PEG 1500 prevents sedimentation of the agarose-in-water gel particles.
- the method of the present invention may optionaly compris the step of decreasing the agarose-in-water droplet size down to 10 ⁇ .
- the reduction of the droplet size may be achieved by passing the pressurized hot emulsion (> 50 °C) through a minute orifice, i.e. by using high pressure homogenizer.
- a sample of gel-like agarose admixture was prepared according to the following procedure: 1 preparation of aqueous solution of agarose: 0.5 g of agarose powder was added to 99.5 g distilled water forming a dispersion of water phase (30%) contained 0.5% of Agarose, the desperation was than heated according to the following regime: lOOw / 40s + 80w / 30s + 80w / 20 s (last heating 2-3 times to get a clear solution).
- the deprecation was cooled down to a temperature in the range of about 65-70°C.
- the aqueous solution of agarose was than mixed with the aqueous solution of the hydrophobic substance prepared above.
- the hydrophobic substance phase: aqueous solution of agarose ration is in the range of 10-15 g of oil phase in 25-30 g of water phase whilst the oil phase is 30-35% of the admixture .
- the admixture was further analyzed according to a desired gel shape, physical appearance (e.g viscosity) and the visual appearance thus when the admixture was homogeneous, with high levels of transparency, the admixture was cooled down to a room temperature forming a gel-like agarose admixture.
- a sample of gel-like agarose admixture was prepared according to the following procedure: 1 preparation of aqueous solution of agarose:
- the aqueous solution of agarose was than mixed with the aqueous solution of the hydrophobic substance prepared above.
- the hydrophobic substance phase: aqueous solution of agarose ration is in the range of 10-15 g of oil phase in 25-30 g of water phase whilst the oil phase is 30-35% of the admixture .
- the admixture was further analyzed according to a desired gel shape, physical appearance (e.g viscosity) and the visual appearance thus when the admixture was homogeneous, the admixture was cooled down to a room temperature forming a gel-like agarose admixture.
- the embodiments were chosen and described to provide the best illustration of the principals of the invention and its practical application, and to enable one of ordinary skill in the art to utilize the invention in various embodiments and with various modifications as are suited to the particular use contemplated. All such modifications and variations are within the scope of the invention as determined by the appended claims when interpreted in accordance with the breadth they are fairly, legally, and equitably entitled.
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- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Insects & Arthropods (AREA)
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- Dermatology (AREA)
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Abstract
On décrit un mélange d'agarose de type gel, utile pour des applications cosmétiques, qui comprend une substance hydrophobe et une solution aqueuse d'agarose. Ce mélange est caractérisé par un réseau réticulé d'agarose-agarose comprenant ladite substance hydrophobe intercalé dans ledit réseau réticulé du réseau d'agarose-agarose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201461976541P | 2014-04-08 | 2014-04-08 | |
US61/976,541 | 2014-04-08 |
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WO2015155639A1 true WO2015155639A1 (fr) | 2015-10-15 |
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PCT/IB2015/052406 WO2015155639A1 (fr) | 2014-04-08 | 2015-04-01 | Mélange d'agarose de type gel pour obtenir un produit cosmétique intermédiaire |
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Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106892747A (zh) * | 2017-02-20 | 2017-06-27 | 深圳市芭田生态工程股份有限公司 | 有机螯合肥料增效剂及其制备方法 |
GB2553192A (en) * | 2016-06-07 | 2018-02-28 | Henkel Ag & Co Kgaa | Emulsion composition containing a cold cream |
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US10251832B2 (en) | 2017-05-26 | 2019-04-09 | Mary Kay Inc. | Cosmetic compositions and methods |
US11534391B2 (en) | 2017-05-26 | 2022-12-27 | Mary Kay Inc. | Cosmetic compositions and methods |
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