WO2015152119A1 - 立体断層像の容積計測装置、容積計測方法及び容積計測プログラム - Google Patents
立体断層像の容積計測装置、容積計測方法及び容積計測プログラム Download PDFInfo
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- WO2015152119A1 WO2015152119A1 PCT/JP2015/059848 JP2015059848W WO2015152119A1 WO 2015152119 A1 WO2015152119 A1 WO 2015152119A1 JP 2015059848 W JP2015059848 W JP 2015059848W WO 2015152119 A1 WO2015152119 A1 WO 2015152119A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0016—Operational features thereof
- A61B3/0025—Operational features thereof characterised by electronic signal processing, e.g. eye models
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0016—Operational features thereof
- A61B3/0041—Operational features thereof characterised by display arrangements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/103—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
Definitions
- the present invention relates to a volumetric measurement apparatus, volumetric measurement method, and volumetric measurement program for a stereoscopic tomogram for measuring the volume of a predetermined portion of a stereoscopic tomogram composed of a plurality of tomographic images of the fundus obtained by an optical coherence tomography. .
- OCT optical coherence tomography
- a three-dimensional tomographic image is constructed from a plurality of B-scan images (tomographic images) obtained by scanning the fundus, and each lesion of the B-scan image is measured.
- the contour is manually set, and the area of the lesion is calculated by the number of pixels.
- the volume of the lesioned part can be obtained by integrating the calculated number of pixels of the lesioned part area for each B-scan image and multiplying it by the actual area per pixel.
- the actual area per pixel varies depending on the subject. This is because the acquired image region changes if the scan width (field angle) is the same even though the axial length varies depending on the subject. For example, in the case of a subject with myopia, the axial length is longer than that of the subject with standard diopter, so the fundus image obtained by scanning is wide, so the actual area per pixel is the standard diopter It becomes larger than that of the eye to be examined.
- Patent Document 1 discloses a technique of scanning a light on the fundus of a subject's eye and receiving the reflected light to obtain a fundus image.
- the scanning field angle is the same as the eye to be examined with the standard diopter
- the fundus is scanned in a wide range. Expands to a larger area than that of the subject's eye with standard diopter. In such a configuration, there is no problem in a test that qualitatively evaluates the change over time of the same subject, but a quantitative comparison with another person becomes impossible.
- Patent Document 1 information on the axial length of the eye to be examined is acquired, and based on this information, the scanning angle is adjusted so that the fundus image is substantially the same as that of the subject eye with standard diopter, and the axial length In the case of a long-sighted eye, control is performed so that the scanning range is narrowed.
- the eye of the eye to be examined can be obtained even if the measurement object such as the lesion has the same volume. If the axial length is different, different volumes are measured, and there is a problem that quantitative evaluation becomes difficult.
- Patent Document 1 In the configuration of Patent Document 1, the scanning angle is corrected based on the information on the axial length of the eye to be examined, and the fundus image is quantitatively evaluated, so that a quantitative comparison with another person can be performed. .
- Patent Document 1 in the configuration for correcting the scanning angle, there is a problem that complicated control is required because the scanning mechanism is controlled.
- the present invention has been made to solve such a problem, and it is possible to obtain a stereoscopic tomographic image capable of accurately measuring the volume of a predetermined portion of the stereoscopic tomographic image without requiring complicated control. It is an object to provide a volume measuring device, a volume measuring method, and a volume measuring program.
- the present invention A tomographic imaging unit that captures a tomographic image of the fundus of the subject's eye and relates to volumetric measurement of a stereoscopic tomogram for measuring the volume of a predetermined part of a stereoscopic tomogram composed of a plurality of tomographic images obtained by scanning the fundus With Focusing the tomographic imaging unit on the fundus according to the diopter of the eye to be examined; Outputting an image correction coefficient corresponding to the diopter of the eye to be inspected obtained from the relationship between the position of the focus optical system at the time of focusing and the size of the fundus image, Processing a signal output from the tomographic imaging unit for each scan to form a tomographic image; Determining a contour of a predetermined portion in the tomographic image for each tomographic image formed by the tomographic image forming unit; Calculating the volume of the predetermined part by correcting each area of the predetermined part determined by the determined contour or its integrated value with the image correction coefficient corresponding to the diopter of the eye
- the volume of a predetermined part is corrected using an image correction coefficient corresponding to the diopter of the eye to be examined, which is obtained from the relationship between the position of the focus optical system at the time of focusing and the size of the fundus image. Even if the subject's eyes have different diopters, the effect of diopter correction is eliminated, and the volume of a predetermined part can be measured more accurately. It becomes possible.
- FIG. 1 is a block diagram showing the entire volume measuring apparatus for measuring the volume of a predetermined part of a three-dimensional tomographic image of the fundus of the eye to be examined.
- Reference numeral 1 denotes a fundus front image photographing unit (fundus camera) 1 that observes and images the fundus (retina) Er of the eye E, and includes an illumination optical system 4, a fundus focus optical system 5, a two-dimensional CCD, and a CMOS.
- the first focus adjustment mechanism 28 are provided.
- the illumination optical system 4 includes an observation light source such as a halogen lamp and a photographing light source such as a xenon lamp. Light from these light sources is guided to the fundus Er via the illumination optical system 4 and the objective lens 10 to illuminate the fundus Er. To do.
- the fundus focus optical system 5 includes optical systems such as a photographing lens and a focusing lens, and guides photographing light reflected by the fundus Er to the imaging device 100 along the photographing optical path to photograph the fundus Er.
- the position of the focusing lens is adjusted so as to match the diopter of the eye to be examined by manually operating the focus knob 28a disposed in the first focus adjustment mechanism 28, and an encoder disposed in the focus knob 28a.
- the position information (diopter information) is output by (not shown).
- the scanning unit 6 includes a known galvanometer mirror 11 for performing a raster scan of light from the low-coherence light source 20 of the tomographic imaging unit (optical coherence tomography) 2 in the x and y directions in FIG. Degree correction lens unit) 27, a second focus adjustment mechanism 29, and the like.
- the fundus scanning method in this embodiment uses raster scanning, but is not limited to raster scanning, and a method of scanning a circle while gradually increasing the radius from the center point, or a method of scanning radially from the center point Etc.
- the scanning unit 6 is optically connected to the tomographic imaging unit 2 that captures a tomographic image of the fundus oculi Er via the connector 7 and the connection line 8.
- the tomographic imaging unit 2 is a well-known one that operates, for example, in the Fourier domain method (spectral domain method), and its detailed configuration is shown in FIG. 2, with a wavelength of 700 nm to 1100 nm, about several ⁇ m to several tens ⁇ m.
- a low-coherence light source 20 that emits light of a temporal coherence length.
- the low coherence light L0 generated by the low coherence light source 20 is guided to the optical coupler 22 by the optical fiber 22a, and is divided into the reference light LR and the signal light LS.
- the reference light LR passes through the optical fiber 22b, the collimator lens 23, the glass block 24, and the density filter 25, and reaches the reference mirror 26 that can move in the optical axis direction for adjusting the optical path length.
- the glass block 24 and the density filter 25 function as delay means for matching the optical path length (optical distance) of the reference light LR and the signal light LS, and as means for matching the dispersion characteristics of the reference light LR and the signal light LS. .
- the signal light LS is guided to the scanning unit 6 through the connector 7 of FIG. 1 by the optical fiber inserted through the connection line 8 through the optical fiber 22c, reaches the fundus Er via the objective lens 10, and reaches the fundus Are scanned in the x and y directions.
- the signal light LS that has reached the fundus oculi is reflected by the fundus oculi Er and returns to the optical coupler 22 by following the above path in reverse.
- the reference light LR reflected by the reference mirror 26 and the signal light LS reflected by the fundus Er are superposed by the optical coupler 22 to become interference light LC.
- the interference light LC is guided to the OCT signal detection device 21 by the optical fiber 22d.
- the interference light LC is converted into a parallel light beam by the collimator lens 21a in the OCT signal detection device 21, and then is incident on the diffraction grating 21b and dispersed, and is imaged on the CCD 21d by the imaging lens 21c.
- the OCT signal detection device 21 generates an OCT signal indicating information in the depth direction (z direction) of the fundus oculi based on the dispersed interference light.
- a focus optical system (diopter correction lens unit) 27 provided in the scanning unit 6 includes focus lenses 27a and 27b (FIG. 3), and the focus lens 27b is movable in the direction of the optical axis, and is capable of viewing the eye to be examined.
- the optical system of the tomographic imaging unit 2 is focused on the fundus according to the degree.
- the second focus adjustment mechanism 29 is interlocked with the first focus adjustment mechanism 28, and when the examiner rotates the focus knob 28a provided in the first focus adjustment mechanism 28, the second focus adjustment mechanism 29 is focused on the fundus.
- FIG. 3 shows a specific configuration of the focus optical system 27 together with other optical systems.
- the signal light LS that has passed through the lenses 27 a and 27 b of the focus optical system 27 is scanned in the y-axis direction by the galvanometer 11 of the scanning unit 6, passes through the objective lens 10, and passes from the pupil Ep of the eye E to the fundus Er. Is incident on.
- the one shown in the upper part is an example of an eye E having a standard diopter, and the axial length of the eye to be examined is indicated by X1.
- the figure shown below is an example of an eye E 'to be examined with a myopic eye, and the eye axis length of the eye E' to be examined is indicated by X2 longer than X1.
- diopter information of the fundus focus optical system 5 is transmitted to the second focus adjustment mechanism, the focus lens 27b is moved along the optical axis by a stepping motor (not shown), and as shown in the lower part of FIG. You can focus on the fundus Er of '.
- the three-dimensional tomographic image measuring apparatus is provided with an image processing device 3 constituted by, for example, a microcomputer built in the fundus front image capturing unit 1 or a personal computer connected to the fundus front image capturing unit 1.
- the image processing apparatus 3 is provided with a control calculation unit 30 composed of a CPU, a RAM, a ROM, and the like.
- the control calculation unit 30 executes an image processing program and a volume measurement program, thereby performing overall image processing and volume measurement. Control processing.
- the control calculation unit 30 is connected to the fundus front image capturing unit 1 and outputs an instruction necessary for capturing the fundus or its tomographic image.
- it receives information necessary for the photographing from the fundus front image photographing unit 1, and controls the photographing process of the fundus and its tomographic image, the image processing process, and the volume measuring process.
- the display unit 31 is configured by, for example, a display device such as an LCD, and displays an image generated or processed by the image processing device 3 and accompanying information such as information on the subject.
- the input unit 32 includes, for example, a mouse, a keyboard, an operation panel, and the like, and is used by an operator to give an instruction to the image processing apparatus 3 and the like.
- the image processing apparatus 3 is provided with a tomographic image forming unit 41.
- the tomographic image forming unit 41 is realized by a dedicated electronic circuit that executes a known analysis method such as a Fourier domain method (spectral domain method), or an image processing program that is executed by the above-described CPU.
- a tomographic image of the fundus oculi Er is formed based on the detected OCT signal.
- the tomographic image formed by the tomographic image forming unit 41 is stored in a storage unit 42 configured by, for example, a semiconductor memory or a hard disk device.
- the storage unit 42 further stores the above-described image processing program, volume measurement program, and the like.
- the image processing unit 50 includes a stereoscopic tomographic image forming unit 51 and a contour determining unit 52.
- the stereoscopic tomographic image forming unit 51 has a plurality of two-dimensional tomographic images (B-scan images) obtained by scanning the fundus Er. A three-dimensional three-dimensional tomographic image is formed.
- the contour determining means 52 determines the contour of a predetermined part such as a lesion in the tomographic image for each tomographic image constituting the stereoscopic tomographic image.
- the contour can be determined, for example, by the user specifying the contour with the mouse of the input unit 32, or can be determined using software for automatically extracting the contour.
- the image correction coefficient output means 53 is composed of a table or a two-dimensional map storing the relationship between the position of the focus optical system at the time of focusing and the size of the fundus image, and an image correction coefficient corresponding to the optical axis position of the focus lens 27b. Is output. This correction coefficient is obtained as follows.
- the diopter information is transmitted to the second focus adjustment mechanism 29, and a stepping motor (not shown) performs FIG. 7, the optical axis position of the focus lens 27b of the focus optical system 27 changes, whereby the measurement length L at the fundus in the y-axis direction at the time of focusing determined by the scanning range of the galvanometer mirror 11 is obtained. And the area of the fundus image changes.
- the measurement length of the eye E to be examined with standard diopter is L
- the measurement length of the eye to be examined E ′ different from the standard diopter is L ′
- L / L ′ is calculated as the volume of the measurement site of the stereoscopic tomographic image.
- the table can be created by experiment or simulation, and when it is obtained by experiment, the diopter and axial length values of a large number of eyes to be examined are measured, and an approximate expression of the distribution is obtained. Since the measurement length at the time of focusing is calculated by tan based on the axial length and the deflection angle of the galvanometer mirror, an expression showing the relationship between the focus knob position and the measurement length is obtained, and the focus knob position R at the time of focusing Then, the ratio of the standard diopter to the measurement length L at that time, that is, the relationship of the correction coefficient ⁇ is obtained as a table.
- the axial length at each diopter is calculated on the model eye, and thereafter the relationship between the focus knob position R at the time of focusing and the correction coefficient ⁇ is obtained as a table by the same operation as described above.
- the table obtained in this way is stored in the form of a two-dimensional map as shown in FIG.
- the volume calculating means 30a calculates the volume of the predetermined part by correcting and integrating each area of the predetermined part determined by the contour determined by the contour determining part 51 with a correction coefficient corresponding to the diopter of the eye to be examined.
- step S1 After the alignment and focus adjustment of the fundus front imaging unit 1 is completed (step S1), the low-coherence light source 20 of the tomographic imaging unit 2 is turned on, and the signal light from the tomographic imaging unit 2 is scanned by the scanning unit 6. , Y direction and raster scan of the fundus Er (step S2). This state is illustrated in FIG. 5, and the region indicated by the alternate long and short dash line where the macular portion of the retina is present is n main scanning lines y1, y2,. A raster scan is performed.
- the signal light LS reflected by the fundus Er is superimposed on the reference light LR reflected by the reference mirror 26 in the tomographic imaging unit 2.
- interference light LC is generated, and an OCT signal is generated from the OCT signal detector 21.
- the image correction coefficient output means 53 When the optical system of the scanning unit 6 is accurately focused on the fundus, the image correction coefficient output means 53 outputs the correction coefficient ⁇ corresponding to the focus knob position R (step S3).
- the focus knob position at the time of focusing is R2
- the image correction coefficient output means 53 has a correction coefficient ⁇ 2 smaller than 1. Is output.
- a tomographic image is taken (step S4), and a tomographic image forming unit 41 is obtained.
- a tomographic image of the fundus oculi Er is formed based on the OCT signal (step S5), and the formed tomographic image is stored in the storage unit.
- the contour determining means 52 has the tomographic images B1, B2, B3, B4. . . . .
- the outline of the predetermined part M such as a lesioned part in the tomographic image is determined every time.
- FIG. 6b shows predetermined portions M1, M2, M3, and M4 of the tomographic images B1, B2, B3, and B4 determined or extracted in this manner.
- the volume calculation means 30a provided in the control calculation unit 30 calculates the area of each part surrounded by the contour line by summing the number of pixels (step S8). Then, the area of each part is multiplied by the correction coefficient obtained by the image correction coefficient output means 53 and integrated to calculate the volume of the predetermined part M (step S9). The volume is calculated by multiplying the area of each part by multiplying the correction coefficient and not adding the corrected areas. You may make it obtain
- the correction coefficient ⁇ 1 in the case of the eye E with standard diopter, the same result as without correction is obtained, but in the case of the eye E ′ for myopia, the correction coefficient is smaller than 1.
- the area of each part becomes a small value, and the volume of the part M, which is an integrated value of the area of each part, becomes small, and the volume value changed for diopter correction can be corrected.
- the volume of a measurement site such as a lesion is corrected using a correction coefficient for correcting an image enlarged or reduced by focus adjustment according to the diopter of the eye to be examined to an image without enlargement or reduction. Therefore, even if the subject's eyes have different diopters, the effect of diopter correction is eliminated, and the subject's eyes having different diopters can be quantitatively compared.
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Abstract
Description
被検眼眼底の断層像を撮影する断層画像撮影ユニットを備え、眼底をスキャンして得られる複数枚の断層像からなる立体断層像の所定部位の容積を測定するための立体断層像の容積計測に関するもので、
前記断層画像撮影ユニットを被検眼の視度に応じて眼底に合焦させること、
合焦時のフォーカス光学系の位置と眼底画像の大きさの関係から得られる被検眼の視度に応じた画像補正係数を出力すること、
前記スキャン毎に断層画像撮影ユニットから出力される信号を処理して断層画像を形成すること、
前記断層画像形成部で形成された各断層画像毎に断層画像内の所定部位の輪郭を決定すること、
前記決定された輪郭で定まる所定部位の各面積あるいはその積算値を被検眼の視度に応じた前記画像補正係数で補正して所定部位の容積を演算すること、
を特徴とする。
2 断層画像撮影ユニット
3 画像処理装置
4 照明光学系
5 眼底フォーカス光学系
6 走査ユニット
20 低コヒーレンス光源
21 OCT信号検出装置
28 第1のフォーカス調整機構
28a フォーカスノブ
29 第2のフォーカス調整機構
30 制御演算部
30a 容積演算手段
31 表示部
32 入力部
41 断層画像形成部
42 記憶部
51 立体断層画像形成手段
52 輪郭決定手段
53 画像補正係数出力手段
Claims (6)
- 被検眼眼底の断層像を撮影する断層画像撮影ユニットを備え、眼底をスキャンして得られる複数枚の断層像からなる立体断層像の所定部位の容積を測定するための立体断層像の容積計測装置であって、
前記断層画像撮影ユニットを被検眼の視度に応じて眼底に合焦させるフォーカス光学系と、
合焦時のフォーカス光学系の位置と眼底画像の大きさの関係から得られる被検眼の視度に応じた画像補正係数を出力する出力手段と、
前記スキャン毎に断層画像撮影ユニットから出力される信号を処理して断層画像を形成する断層画像形成部と、
前記断層画像形成部で形成された各断層画像毎に断層画像内の所定部位の輪郭を決定する輪郭決定手段と、
前記決定された輪郭で定まる所定部位の各面積あるいはその積算値を被検眼の視度に応じた前記画像補正係数で補正して所定部位の容積を演算する演算手段と、
を備えたことを特徴とする立体断層像の容積計測装置。 - 前記画像補正係数は、実験もしくはシミュレーションにより求められる被検眼の視度と眼軸長の値の関係に基づき合焦時のフォーカス位置情報と眼底画像の拡大率から求められることを特徴とする請求項1に記載の立体断層像の容積計測装置。
- 前記所定部位の輪郭は、ユーザーが輪郭を指定することにより決定されることを特徴とする請求項1又は2に記載の立体断層像の容積計測装置。
- 前記所定部位の輪郭は、輪郭を自動抽出するソフトウェアを用いて決定されることを特徴とする請求項1又は2に記載の立体断層像の容積計測装置。
- 被検眼眼底の断層像を撮影する断層画像撮影ユニットを備え、眼底をスキャンして得られる複数枚の断層像からなる立体断層像の所定部位の容積を測定するための立体断層像の容積計測方法であって、
前記断層画像撮影ユニットを被検眼の視度に応じて眼底に合焦させる工程と、
合焦時のフォーカス光学系の位置と眼底画像の大きさの関係から得られる被検眼の視度に応じた画像補正係数を出力する工程と、
前記スキャン毎に断層画像撮影ユニットから出力される信号を処理して断層画像を形成する工程と、
前記断層画像形成部で形成された断層画像毎に断層画像内の所定部位の輪郭を決定する工程と、
前記決定された輪郭で定まる所定部位の各面積あるいはその積算値を被検眼の視度に応じた前記画像補正係数で補正して所定部位の容積を演算する工程と、
を備えたことを特徴とする立体断層像の容積計測方法。 - 請求項5に記載の容積計測方法をコンピュータに実行させることを特徴とする立体断層像の容積計測プログラム。
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EP15774190.1A EP3127473A4 (en) | 2014-03-31 | 2015-03-30 | Volume measuring device, volume measuring method, and volume measuring program for three-dimensional tomographic images |
US15/300,191 US9820649B2 (en) | 2014-03-31 | 2015-03-30 | Volume measuring device, volume measuring method, and volume measuring program for three-dimensional tomographic image |
JP2016511864A JP6602289B2 (ja) | 2014-03-31 | 2015-03-30 | 立体断層像の容積計測装置、容積計測方法及び容積計測プログラム |
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JP2006122160A (ja) * | 2004-10-27 | 2006-05-18 | Kowa Co | 眼科測定装置 |
JP2006334044A (ja) * | 2005-06-01 | 2006-12-14 | Kowa Co | 眼科測定装置 |
JP2009000354A (ja) * | 2007-06-22 | 2009-01-08 | Nidek Co Ltd | 眼科測定装置 |
JP2012011142A (ja) * | 2010-07-05 | 2012-01-19 | Nidek Co Ltd | 眼底撮影装置 |
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EP1652469A3 (en) | 2004-10-27 | 2006-06-07 | Kowa Company Ltd. | Ophthalmological measuring apparatus |
JP5058627B2 (ja) * | 2007-02-26 | 2012-10-24 | 株式会社トプコン | 眼底観察装置 |
JP4971872B2 (ja) * | 2007-05-23 | 2012-07-11 | 株式会社トプコン | 眼底観察装置及びそれを制御するプログラム |
JP5324839B2 (ja) * | 2008-06-19 | 2013-10-23 | 株式会社トプコン | 光画像計測装置 |
JP5628636B2 (ja) * | 2010-11-09 | 2014-11-19 | 株式会社トプコン | 眼底画像処理装置及び眼底観察装置 |
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- 2015-03-30 JP JP2016511864A patent/JP6602289B2/ja active Active
- 2015-03-30 WO PCT/JP2015/059848 patent/WO2015152119A1/ja active Application Filing
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Patent Citations (4)
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JP2006122160A (ja) * | 2004-10-27 | 2006-05-18 | Kowa Co | 眼科測定装置 |
JP2006334044A (ja) * | 2005-06-01 | 2006-12-14 | Kowa Co | 眼科測定装置 |
JP2009000354A (ja) * | 2007-06-22 | 2009-01-08 | Nidek Co Ltd | 眼科測定装置 |
JP2012011142A (ja) * | 2010-07-05 | 2012-01-19 | Nidek Co Ltd | 眼底撮影装置 |
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JP2019054992A (ja) * | 2017-09-21 | 2019-04-11 | 株式会社トプコン | 眼科装置及びプログラム |
Also Published As
Publication number | Publication date |
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EP3127473A4 (en) | 2018-01-17 |
US20170135578A1 (en) | 2017-05-18 |
JP6602289B2 (ja) | 2019-11-06 |
JPWO2015152119A1 (ja) | 2017-04-13 |
EP3127473A1 (en) | 2017-02-08 |
US9820649B2 (en) | 2017-11-21 |
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