WO2014148847A8 - 히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물 - Google Patents

히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물 Download PDF

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WO2014148847A8
WO2014148847A8 PCT/KR2014/002364 KR2014002364W WO2014148847A8 WO 2014148847 A8 WO2014148847 A8 WO 2014148847A8 KR 2014002364 W KR2014002364 W KR 2014002364W WO 2014148847 A8 WO2014148847 A8 WO 2014148847A8
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hyaluronic acid
preparation
adhesive composition
present
acid prepared
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PCT/KR2014/002364
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English (en)
French (fr)
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WO2014148847A1 (ko
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강대중
김태윤
강재훈
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일동제약주식회사
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Priority to JP2016504255A priority Critical patent/JP6370002B2/ja
Priority to CN201480029053.4A priority patent/CN105324486B/zh
Priority to EP14767484.0A priority patent/EP2977460B1/en
Publication of WO2014148847A1 publication Critical patent/WO2014148847A1/ko
Priority to US14/859,975 priority patent/US20160009828A1/en
Publication of WO2014148847A8 publication Critical patent/WO2014148847A8/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Zoology (AREA)
  • Molecular Biology (AREA)
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  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 체내 저분해 속도를 갖는 히알루론산의 제조방법 및 상기 방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물에 대한 것으로, 더욱 상세하게는 스트랩토코커스 디스갈락티애 9103 균주 (KCTC11818BP)를 탄소원 및 질소원이 포함하는 배지에서 배양하는 단계를 포함하는 체내 저분해 속도를 가지는 히알루론 산의 제조방법 및 상기 방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물을 제공한다. 본 발명의 제조방법으로 제조된 히알루론산은 350만 Da 내지 1000만 Da의 고분자 히알루론산으로, 체내 분해 속도가 느려 유착 방지효과가 탁월하다. 본 발명의 제조방법으로 제조된 히알루론산을 포함하는 본 발명의 유착방지용 조성물은 가교하지 않은 히알루론산을 사용하므로써, 기존의 가교제 및 화합물을 포함하는 유착방지용 조성물이 가진 문제점 및 기존의 히알루론산이 가진 문제점을 개선할 수 있다.
PCT/KR2014/002364 2013-03-20 2014-03-20 히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물 WO2014148847A1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2016504255A JP6370002B2 (ja) 2013-03-20 2014-03-20 ヒアルロン酸の製造方法及び前記製造方法で製造されたヒアルロン酸を含む癒着防止用組成物
CN201480029053.4A CN105324486B (zh) 2013-03-20 2014-03-20 透明质酸的制造方法和含有通过上述制造方法制造的透明质酸的防粘连用组合物
EP14767484.0A EP2977460B1 (en) 2013-03-20 2014-03-20 Preparation method for hyaluronic acid, and anti-adhesive composition comprising hyaluronic acid prepared by same preparation method
US14/859,975 US20160009828A1 (en) 2013-03-20 2015-09-21 Preparation method for hyaluronic acid, and anti-adhesive composition comprising hyaluronic acid prepared by same preparation method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130029876A KR101598329B1 (ko) 2013-03-20 2013-03-20 히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물
KR10-2013-0029876 2013-03-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/859,975 Continuation US20160009828A1 (en) 2013-03-20 2015-09-21 Preparation method for hyaluronic acid, and anti-adhesive composition comprising hyaluronic acid prepared by same preparation method

Publications (2)

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WO2014148847A1 WO2014148847A1 (ko) 2014-09-25
WO2014148847A8 true WO2014148847A8 (ko) 2015-10-22

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PCT/KR2014/002364 WO2014148847A1 (ko) 2013-03-20 2014-03-20 히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물

Country Status (6)

Country Link
US (1) US20160009828A1 (ko)
EP (1) EP2977460B1 (ko)
JP (1) JP6370002B2 (ko)
KR (1) KR101598329B1 (ko)
CN (1) CN105324486B (ko)
WO (1) WO2014148847A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUA20164153A1 (it) 2016-06-07 2017-12-07 Jointherapeutics S R L Composizioni polisaccaridiche impiegabili nella riparazione tissutale
WO2018106924A1 (en) 2016-12-09 2018-06-14 Cummins Inc. Spark plug for an internal combustion engine having a combustion pre-chamber
KR102489403B1 (ko) * 2018-10-29 2023-01-17 엠앤에이치바이오 주식회사 신규한 스트렙토코커스 속 ubc-u46 균주 및 이를 이용한 히알루론산 생산 방법
EP3797800A1 (en) * 2019-05-02 2021-03-31 Institut National De La Sante Et De La Recherche Medicale - Inserm Hyaluronic acid hydrogels with prolonged antimicrobial activity
KR102546437B1 (ko) * 2021-03-15 2023-06-21 금오공과대학교 산학협력단 생체적합성 고분자를 포함하는 파우더형 유착방지제 및 그의 제조방법

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US5496726A (en) * 1993-04-16 1996-03-05 Lucky Limited Streptococcus zooepidemicus medium and process for preparing hyaluronic acid
JP3632197B2 (ja) * 1996-10-15 2005-03-23 チッソ株式会社 高分子量ヒアルロン酸もしくはその塩の製造法
CN1101405C (zh) 1997-08-22 2003-02-12 电气化学工业株式会社 透明质酸凝胶的制备方法、用此方法制得的透明质酸及包含这种凝胶的医用材料
DE60014400T2 (de) 1999-07-28 2005-10-06 United States Surgical Corp., Norwalk Antiadhäsionsschicht aus hyaluronsäure
AU2003252566A1 (en) * 2002-08-19 2004-03-03 Kolon Ind. Inc. Microorganism producing hyaluronic acid and purification method of hyaluronic acid
KR20090012439A (ko) 2007-07-30 2009-02-04 주식회사 핸슨바이오텍 기관 유착 방지 특성을 갖는 히알루론산 및카르복시메칠셀룰로즈 복합체 유도체 필름 및 겔 및 그제조방법
EP2031053A1 (en) * 2007-08-31 2009-03-04 The University Of Queensland Production of HA
WO2010010631A1 (ja) * 2008-07-25 2010-01-28 電気化学工業株式会社 ヒアルロン酸の製造方法
KR101087969B1 (ko) * 2008-10-31 2011-12-01 일동제약주식회사 미생물 배양에 의한 히알우론산을 생산하는 방법
KR101062068B1 (ko) * 2008-12-01 2011-09-02 포항공과대학교 산학협력단 유착방지용 조성물
WO2010125069A1 (en) * 2009-04-28 2010-11-04 Pharmasurgics In Sweden Ab Hyaluronic acid for preventing post surgical adhesions
KR101074467B1 (ko) 2009-05-08 2011-10-17 주식회사 휴메딕스 히알루론산 및 ｌ-아르기닌을 함유하는 유착방지제
KR101132114B1 (ko) * 2009-09-15 2012-04-05 일동제약주식회사 히알루론산의 분자량을 조절하는 방법
WO2011109130A1 (en) * 2010-03-01 2011-09-09 Tautona Group Lp Threads of hyaluronic acid and methods of use thereof
KR101091072B1 (ko) 2010-03-04 2011-12-08 신효산업 주식회사 2단 빨대
KR101227248B1 (ko) 2010-04-14 2013-01-28 원제돈 다용도 압력 조리장치
CN101912633A (zh) * 2010-08-03 2010-12-15 孙伟庆 一种透明质酸海绵及其制备方法
WO2012057381A1 (ko) * 2010-10-29 2012-05-03 주식회사 휴메딕스 히알루론산 및 ｌ-아르기닌을 함유하는 유착방지제
TW201313261A (zh) * 2011-08-26 2013-04-01 Lg Life Sciences Ltd 防沾黏劑及使用該防沾黏劑之預防沾黏之方法
KR101322227B1 (ko) * 2011-09-30 2013-10-28 일동제약주식회사 스트렙토코커스 디스갈락티애 ｉｄ9103 균주 및 이를 이용한 히알루론산 생산 방법

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Publication number Publication date
JP6370002B2 (ja) 2018-08-08
CN105324486B (zh) 2020-09-01
KR20140115149A (ko) 2014-09-30
JP2016515821A (ja) 2016-06-02
CN105324486A (zh) 2016-02-10
EP2977460A1 (en) 2016-01-27
EP2977460A4 (en) 2016-11-16
KR101598329B1 (ko) 2016-02-29
WO2014148847A1 (ko) 2014-09-25
EP2977460B1 (en) 2019-05-08
US20160009828A1 (en) 2016-01-14

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