WO2014136676A1 - Tube pourvu d'un bouchon ayant la structure d'un bouchon de type à pousser - Google Patents

Tube pourvu d'un bouchon ayant la structure d'un bouchon de type à pousser Download PDF

Info

Publication number
WO2014136676A1
WO2014136676A1 PCT/JP2014/055072 JP2014055072W WO2014136676A1 WO 2014136676 A1 WO2014136676 A1 WO 2014136676A1 JP 2014055072 W JP2014055072 W JP 2014055072W WO 2014136676 A1 WO2014136676 A1 WO 2014136676A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
lid
flange
tube body
slit
Prior art date
Application number
PCT/JP2014/055072
Other languages
English (en)
Japanese (ja)
Inventor
新一郎 角田
容子 中鼻
Original Assignee
Kakuda Shinichiro
Nakahana Yoko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kakuda Shinichiro, Nakahana Yoko filed Critical Kakuda Shinichiro
Priority to JP2014527404A priority Critical patent/JP5658849B1/ja
Publication of WO2014136676A1 publication Critical patent/WO2014136676A1/fr

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes

Definitions

  • the present invention relates to a microtube used for storing and storing a large number of samples.
  • the microtube has, for example, applications for storing and storing drug discovery samples in the drug discovery field, and for storing and storing samples and specimens that hold genetic information such as DNA in the medical field.
  • the micro tube array type stores and stores small sample storage bodies called individual micro tubes arranged in an array on a storage rack.
  • Microtubes are plastic storage tubes with a height of several centimeters. Each tube is independent, and can be used alone or as a sample storage body, or stored in an array on a storage rack. By doing so, it can also be used as a microtube array for storing and storing a large number of samples at the same time.
  • Microtubes are plastic storage tubes with a height of several centimeters. Each tube is independent, and can be used alone or as a sample storage body, or stored in an array on a storage rack. By doing so, it can also be used as a microtube array for storing and storing a large number of samples at the same time.
  • the microtube has a structure including an opening on the upper surface and a sample storage body that can store a sample therein, and a lid that firmly seals the upper surface opening of the sample storage body that stores the sample.
  • a threaded screw system For example, a male screw is provided on the outer surface of the upper surface of the sample storage body, a female screw is provided on the inner peripheral wall surface of the lid body, and both of them are screwed to open or close.
  • a male screw is provided on the outer peripheral wall surface and the both are screwed to open and close.
  • a push-in plug system is another example.
  • a plug portion serving as a plug with respect to the upper surface opening of the sample container and an operation unit for pushing the plug portion.
  • the simple shape is a cylindrical stopper that is slightly tapered like a rubber stopper for a flask.
  • a configuration example is known in which a flange is provided in the upper part of the lid so as to contact the edge of the upper surface opening of the sample storage body so that the stopper does not fall inside.
  • each microtube is an independent sample storage body, it is necessary to individually identify each storage body. Attention has been focused on a technique of writing a bar code or the like obtained by encoding various data and management information, and reading and managing the bar code or two-dimensional code in the management process.
  • FIG. 10 is a view showing a conventional push-plug microtube. A part of the structure of the internal microtube is also shown by a broken line for easy understanding of the mechanism.
  • the top opening of the microtube is sealed with a lid, but in the configuration example of FIG. 10, a stopper is provided at the bottom of the lid, and a flange that abuts the top of the sample container is provided at the top of the stopper. It has been. After the sample is put into the sample container, the upper surface of the sample container can be tightly sealed with a stopper by the lid.
  • JP 2001-158450 A Japanese Patent Laid-Open No. 11-113559
  • the conventional push-plug type microtube is widely used.
  • the lid is simply pushed into the top opening of the microtube from above, the lid is plugged.
  • a problem may occur in which the body is unexpectedly detached from the top opening of the microtube.
  • the lid will not be unexpectedly removed from the top opening of the microtube unless the lid rotates. However, when attaching or removing the lid, it must be rotated while gripping the lid. . Even if the work is performed with a robot arm or the like, high work accuracy is required, and the attaching and detaching operations of the lid are costly and time consuming. Therefore, a push-type lid that can be attached simply by pushing from above is excellent in operability, but conversely, the push-in method is more likely to come off than the screw-in method.
  • the push-type lid may come off due to various factors such as changes in atmospheric pressure.
  • One is that the sample is put into the microtube and then the push plug is pushed in. At that time, the internal pressure increases. The lid may be gradually pushed up and removed by the internal pressure. If the internal pressure is high, for example, slight vibration applied from the outside, external force applied inadvertently when attaching / detaching other microtubes, gas generated by the sample body, The lid may come off due to various factors such as changes in atmospheric pressure.
  • the present invention has been made in view of the above-described problems, and is attached by simply pushing the lid into the upper surface opening of the sample storage body while adopting a push-type lid that is easy to attach and remove.
  • An object of the present invention is to provide a tube with a stopper to which the lid can be firmly attached and the lid in the attached state is not accidentally detached.
  • the stopper-equipped tube of the present invention comprises a tube body that contains a sample body, a plug portion that is pushed into the tube body, and a flange portion that has a larger diameter than the plug portion.
  • a slit portion that receives and holds a part of the outer peripheral piece of the flange in a state in which the plug portion is fitted inside the tube body on a side surface near the upper surface of the tube body; and
  • a locking portion through which the flange portion cannot pass any more is provided at the lower portion, a part of the outer peripheral piece of the flange of the lid body is held by the slit portion, and the lid body can be fixed near the upper surface of the tube body. It is a tube with a stopper.
  • an overhanging portion that protrudes inward so as to prevent passage of a part of the outer peripheral piece of the flange portion is provided on the upper portion of the slit portion, and the flange portion protrudes from the upper side when the lid is pressed from above.
  • the flange portion cannot pass upward if it can be passed over the portion but fits in the slit portion, and the projecting portion is in contact with the plug portion fitted into the tube body. It is preferable that the lid is braked up and down by the portion.
  • the projecting shape of the projecting part to the inside of the tube body includes various three-dimensional projecting planes, three-dimensional projecting curved surfaces, claw-shaped projections, polygonal projections, irregular projections, and combinations thereof. Shape is possible.
  • the projecting shape may be a three-dimensional object that prevents passage of some flange inside the tube body.
  • the slit width of the slit portion matches the thickness of the flange, and the flange fitted to the slit portion is fitted and clamped so as not to move in the vertical direction. It is preferable.
  • the outer peripheral piece of the flange portion gets over the protruding portion, and further, a part of the outer peripheral piece of the flange is in the slit portion below it. Since it fits in, once it fits in a slit part, it can clamp so that a flange part may not move to an up-down direction. As a result, the lid can be fixed so that it cannot be easily removed by simply pushing the lid into the upper surface opening of the tube body.
  • the material of the lid is preferably a thermoplastic or thermosetting material.
  • plastic, natural rubber, synthetic rubber, silicone and the like are preferable. With these materials, the flange portion can be deformed so as to pass through the overhanging portion without breaking, and the shape can be restored after passage and a part of the outer peripheral piece of the flange can be fitted into the slit portion.
  • the tube body may be provided so as to be arranged on the circumference at intervals of 90 degrees.
  • projection part and a slit part is provided it is not specifically limited, Any of circular, a polygon, a curve, or those combinations may be sufficient. While the overhanging portion is provided on the inner side, the outer shape can be variously designed.
  • the robot arm can be easily used as a target for the arm when the lid is operated.
  • the concave portion is provided on the upper surface of the lid, it is possible to adopt a configuration in which a film sheet for sealing the upper surface of the concave portion of the lid is attached. If a concave portion is provided on the upper surface of the lid and stored for a long period of time, foreign substances such as bacteria and fine dust may adhere to the inside. In normal outside air, foreign substances such as bacteria and fine dust are floating, and bacteria and fine dust may enter the recess depending on the storage state.
  • the stopper-equipped tube of the present invention may be provided with an information writing area where an identification code can be printed or pasted on either the side surface or the bottom surface of the tube body, or both. Further, an information writing area where an identification code can be printed or pasted can be provided on the upper surface of the lid.
  • the stopper portion of the sample storage body is simply inserted by pushing the cover body into the upper surface opening of the sample storage body while adopting a push-type cover body that is easy to attach and remove. While sealing the upper surface opening, the flange can get over the overhanging portion, and further, a part of the outer peripheral piece of the flange can be fitted into the slit portion below it, so that the flange can be held vertically. As a result, the lid can be easily fixed without being removed simply by being pushed into the upper opening of the tube body of the sample storage body.
  • FIG. 1 is a diagram simply showing the structure of a tube 100 with a stopper according to the present invention.
  • FIG. 1A is a front view. Note that the rear view, right side view, and left side view are the same as the front view, and are not shown.
  • 1 (b) is a side view rotated 45 degrees to the right around the central axis
  • FIG. 1 (c) is a plan view
  • FIG. 1 (d) is a bottom view
  • FIG. 1 (e) is AA.
  • FIG. 2 is a view showing the sample storage body 120 extracted from the configuration of the tube 100 with stopper.
  • FIG. 2A is a front view.
  • FIG. 2 (b) is a side view rotated 45 degrees to the right around the central axis
  • FIG. 2 (c) is a plan view
  • FIG. 2 (d) is a bottom view
  • FIG. 2 (e) is a cross-sectional view along line BB
  • FIG. 2 (f) is a cross-sectional view taken along the line CC
  • FIG. 2 (g) is a perspective view showing a three-dimensional structure.
  • FIG. 3 is a view showing the lid 110 taken out of the configuration of the tube 100 with a stopper. The top surface seal 114 is removed.
  • FIG. 3A is a front view.
  • FIG. 3B is a plan view
  • FIG. 3C is a bottom view
  • FIG. 3D is a cross-sectional view taken along line AA.
  • the tube 100 with a stopper is configured to include a lid 110 and a tube body 120 for storing a sample.
  • the lid 110 and the tube body 120 will be described in order.
  • the lid 110 has a lid structure that opens and closes an opening on the upper surface of the sample storage body 120.
  • the lid 110 is attached to the sample storage body 120 by a push-in method.
  • the material of the lid 110 is preferably a thermoplastic or thermosetting material such as plastic, natural rubber, synthetic rubber, or silicone.
  • the lid body 110 needs to pass through the overhanging portion 124 due to the deformation of the flange portion 112, and after the passage, the shape is restored to the original shape and fitted into the slit body 125. Elasticity that spreads out is necessary.
  • a plug portion 111, a flange 112, and a recess portion 113 are provided as a member of the lid body 110.
  • the plug portion 111 has a cylindrical shape in this configuration example, and is a member that becomes a plug to be pushed into from the upper surface opening of the tube body 120.
  • the outer diameter of the plug portion 111 is R4, and the outer diameter of the flange is R5.
  • the outer diameter R4 of the stopper 111 is slightly larger than the inner diameter R1 of the tube body 120.
  • the stopper 111 functions as a kind of stopper when the stopper 111 fits inside the sample storage body 120, and the upper surface opening of the tube 121 is opened. It is a member that can be sealed. That is, the relationship of the following formula 1 is established. [Equation 1] R1 ⁇ R4 ⁇ R5
  • the flange 112 is a hook structure attached to the upper part of the plug part 111, and is a member that comes into contact with and engages with the upper surface edge of the tube body 121.
  • the outer diameter R5 of the flange 112 matches the inner diameter R2 of the cylinder 123 shown in FIG. 2 or is smaller than the inner diameter R2 of the cylinder 123.
  • the flange 112 has the cylinder 123. The size can pass.
  • the outer diameter R5 of the flange 112 is larger than the inner diameter R1 of the tube body 121 of the sample storage body 120, and cannot enter the tube body 121 of the sample storage body 120, and the upper edge of the tube body 120 It is the size which contacts and is locked. That is, the relationship of the following formula 2 is established. [Equation 2] R4 ⁇ R5 ⁇ R2
  • the recess 113 is a recess provided on the upper surface of the lid 110. Although it is not an essential configuration for the present invention, if there is a dent, it becomes a target for fitting the tip of the arm when operating the opening and closing of the lid 110 with the robot arm. In this configuration, the dent 113 is a cylindrical dent, but may be any shape that matches the tip of the robot arm. By inserting the tip of the robot arm into the recess 113 and pushing the robot arm downward as it is, the lid 110 can be surely pushed down by the tip of the robot arm, as will be described later. Easier to push into body 120
  • the recess 113 Another application of the recess 113 is that the sample is stored in the sample storage body 120, sealed, stored, and then inspected after the sample is inspected.
  • a take-out operation in which a syringe is pushed up to pierce the inside of the sample storage body 120 and the sample is sucked, it can also be used as a dent provided so that the syringe needle can be pushed up and pierced easily. That is, since the bottom portion of the recess 113 is thin, it is easy to pierce the recess 113 by pushing the injection needle.
  • a method of attaching the lid 110 to the sample storage body 120 will be described later.
  • the tube body 120 is a test tubular container having an upper surface opening on the upper surface and accommodating a sample.
  • the tube body 120 is an example of a test tubular cylindrical shape, but may have other shapes depending on the application.
  • a configuration example having a structure for fixing a test tubular tube portion and a lid 110 provided in the vicinity of the upper surface opening is provided.
  • the material of the tube body 120 is preferably made of glass or plastic which is a transparent or translucent material in order to visually check the storage state of the sample sealed inside.
  • the transparent plastic material for the tube body 120 may be plastic with high chemical resistance (for example, polypropylene, polyethylene, polyethylene terephthalate, polybutylene terephthalate, polycarbonate, etc.), natural rubber, synthetic rubber, silicone, or the like.
  • a material obtained by selecting and blending a plurality of materials may be used as a raw material. That is, the transparent plastic material may be a polymer alloy composed of two or more kinds of resins.
  • the transparent plastic material is polypropylene.
  • Polypropylene is a chemically stable material, has high chemical resistance and high transparency, and is a suitable material as one member of the sample container.
  • the tube body 120 has a shape like a so-called test tube, but has an opening at the upper end, a body portion of a small cylinder, and a bottom structure having a spindle shape.
  • the inner diameter of the sample storage portion of the tube body 120 is R1.
  • the outer diameter R4 of the plug portion 111 of the lid 110 is slightly larger than the inner diameter R1 of the tube body 120, and the plug portion 111 fits inside the tube body 120. By doing so, the upper surface opening of the tube body 120 is sealed.
  • the height of the tube body 120 is preferably higher than the height of the lattice frame of the storage rack when stored in the storage rack. Since the tube 100 with a stopper is repeatedly stored and taken out from the storage rack, if the tube 100 with the stopper protrudes from the lattice frame, it can be easily taken out by hand or a robot arm.
  • the cylinder body 123, the overhanging portion 124, the slit portion 125, and the locking portion 129 are provided. Yes.
  • the inner diameter R2 of the cylindrical body 123 is equal to the outer diameter R5 of the flange 112 or larger than the outer diameter R5 of the flange 112, and as shown in [Equation 2] above, the lid The flange 112 of the body 110 can easily pass through the cylindrical body 123.
  • the projecting portion 124 is a structure provided on the inner peripheral wall surface side of the cylindrical body 123 and is a structure projecting inward so as to prevent passage of a part of the outer peripheral piece of the flange portion 112.
  • the shape of the edge of the overhanging portion 124 is not particularly limited. It may be a straight line, an inwardly bulging curve, a knurled irregular shape, or the like. That is, there are various shapes such as a three-dimensional projecting plane, a three-dimensional projecting curved surface, a claw-shaped projection, a polygonal projection, an indeterminate projection, and a combination thereof. Things are possible. In this configuration example, a three-dimensional projecting plane having straight edges is formed.
  • the contact area with the flange portion 112 varies depending on the shape of the overhanging portion 124, if the contact area with the flange portion 112 becomes too large, the flange portion 112 cannot pass through the overhanging portion 124, but as shown in FIG. If is linear, the contact area with the flange portion 112 is moderate.
  • the overhanging portion 124 protrudes inward, as shown in FIG. 2 (e), when the facing distance from the surface of the overhanging portion 124 to the facing surface is L1, first, the plug portion 111 passes through the tube body. Since the inside of 120 needs to be sealed, the facing distance L1 needs to be equal to or greater than the outer diameter R4 of the plug portion 111. However, since the projecting portion 124 is a structure projecting inward so as to prevent passage of a part of the outer peripheral piece of the flange portion 112 when the lid 110 passes, the facing distance L1 is the outer diameter R5 of the flange 112. Must be smaller. That is, there is a relationship of the following formula 3.
  • Equation 3 R4 ⁇ L1 ⁇ R5
  • Equation 4 Equation 4
  • the slit portion 125 is a slit provided on a side surface near the upper surface of the tube body 120 and has a structure for receiving and holding a part of the outer peripheral piece of the flange portion 112.
  • the slit width D1 of the slit portion 125 is equal to or slightly larger than the thickness D2 of the flange 112
  • the flange 112 fitted to the slit portion 125 may be fitted and sandwiched so as to brake in the vertical direction. it can.
  • the slit width D1 of the slit portion 125 is slightly larger than the thickness D2 of the flange 112, the flange 112 is likely to be accommodated in the slit portion 125. As shown in FIG.
  • the plug portion 111 is not in the tube body. If the margin in the vertical direction is such that it does not escape from 120, the sealing property of the tube body 120 is maintained, and the storage state of the sample is not affected.
  • the locking portion 129 is a structure that is provided below the slit portion 125 and stops the flange portion 112 from passing further.
  • the engaging portion 129 may be a protruding structure, or may be a shoulder portion of the inner wall surface of the tube body 120. In this configuration example, as shown in FIGS. 2 (f) and 2 (g), the locking portion 129 is a shoulder portion of the inner wall surface of the tube body 120.
  • FIG. 4 is a diagram simply showing how the flange 112 of the lid 110 passes through the overhanging portion 124 and then fits into the slit portion 125.
  • FIG. 4 shows a longitudinal section so that the relationship between the lid 110 and the overhanging portion 124 can be easily understood.
  • 4 (a) to 4 (c) are diagrams showing the relationship between the cylindrical portion 123 where the overhanging portion 124 is not provided and the lid 110, and FIGS. 4 (d) to 4 (f) It is a figure which shows the relationship between the location in which the overhang
  • the cylindrical portion 123 not provided with the overhanging portion 124 has an opposing distance of L1, and is larger than the outer diameter R4 of the plug portion 111 of the lid 110 from the relationship of [Equation 4], and the plug portion 111 passes smoothly. Furthermore, since the inner diameter R2 of the cylindrical portion 123 is equal to or larger than the outer diameter R5 of the flange 112 of the lid body 110, the flange 112 passes smoothly, and the lower edge of the flange 112 is the tube body 120 as shown in FIG. It can approach to the position which contact
  • the plug portion 111 at the lower part of the lid 110 has an outer diameter R4.
  • the flange 112 at the top of the lid 110 becomes a bottleneck because the outer diameter R5 of the flange 112 is larger than the inner diameter R3 of the overhanging portion 124, and it is gripped.
  • the flange 112 is an elastic material, the flange 112 of the lid 110 cannot easily pass through the overhanging portion 124.
  • FIG. 124 can be passed.
  • the contact area with the flange portion 112 varies depending on the shape of the overhanging portion 124, and if the contact area with the flange portion 112 becomes too large, the flange portion 112 cannot pass through the overhanging portion 124. These edges are straight, and the contact area with the flange portion 112 becomes appropriate and can pass through.
  • the flange 112 has an elastic force even if it is deformed once, and can be restored to its original shape when the external force is lost. That is, as shown in FIG. 4 (f), the flange 112 loses the drag received from the overhanging portion 124 after passing through the overhanging portion 124, so that its shape is restored again by its own elastic force.
  • the slit portion 125 is provided immediately below the overhang portion 124. Therefore, when the shape of the flange 112 is restored as shown in FIG. For example, a part of the outer peripheral piece of the flange 112 is fitted into the slit portion 125.
  • the slit width D1 of the slit portion 125 matches or is slightly larger than the thickness D2 of the flange 112, the flange 112 fitted to the slit portion 125 is fitted and sandwiched so as to brake in the vertical direction. If the slit width D1 of the slit portion 125 is slightly larger than the thickness D2 of the flange 112, the flange 112 is likely to be accommodated in the slit portion 125. As shown in FIG. 1, even when the slit width D1 of the slit portion 125 is larger than the thickness D2 of the flange 112 and there is a margin that allows the flange 112 to move up and down slightly, the plug portion 111 is removed from the tube body 121. If the margin in the vertical direction is such that it does not come out, the sealability of the sample storage body 120 is maintained and the storage state of the sample is not affected.
  • the lower edge of the slit portion 125 is a part of the locking body 129. That is, in a posture in which a part of the outer peripheral piece of the flange 112 is fitted, the lid body 110 is in a state where the plug portion 111 is fitted into the tube body 120 and the upper surface of the tube body 120 is sealed, and the lid body is left as it is. If the posture of 110 is fixed, the tube body 120 is fitted and clamped so as not to move in the vertical direction with the lid 110 attached in a correct posture.
  • the stoppered tube 100 of the present invention with the lid 110 correctly attached is obtained.
  • the tube body 120 of the sample storage body 120 is attached in a state where the tube body 120 is sealed by the stopper portion 111 of the lid body 100 and the flange 112 of the lid body 110 is firmly fitted to the slit portion 125, which is no longer easy.
  • the lid 110 is fixed so as not to be removed.
  • the number and position of the overhanging portion 124 and the slit portion 125 are not limited. However, since the flange 112 of the lid 110 is fixedly held by the slit portion 125, the set of the overhanging portion 124 and the slit portion 125 is evenly arranged with respect to the flange 112. It is preferable to arrange.
  • FIG. 5 shows a variation example of the number and position of the set of the overhanging portion 124 and the slit portion 125.
  • the number of sets of the overhanging portion 124 and the slit portion 125 is two, it is preferable to provide the sets 180 degrees in a circular shape of the cylindrical body 123.
  • the number of sets of the projecting portions 124 and the slit portions 125 is three, it is preferable to provide the sets 120 degrees in a circular shape of the cylindrical body 123.
  • FIG. 5A when the number of sets of the overhanging portion 124 and the slit portion 125 is two, it is preferable to provide the sets 180 degrees in a circular shape of the cylindrical body 123.
  • the number of sets of the projecting portions 124 and the slit portions 125 is three, it is preferable to provide the sets 120 degrees in a circular shape of the cylindrical body 123.
  • the number of sets of the projecting portions 124 and the slit portions 125 when the number of sets of the projecting portions 124 and the slit portions 125 is four, it is preferable to provide the sets 90 degrees in a circular shape of the cylindrical body 123.
  • the number of sets of the overhanging portion 124 and the slit portion 125 when the number of sets of the overhanging portion 124 and the slit portion 125 is six, it is preferable to provide the sets 60 degrees in a circular shape of the cylindrical body 123.
  • the number of sets of the overhanging portion 124 and the slit portion 125 increases, the length of the outer peripheral piece of the flange 112 captured by the slit portion 124 becomes smaller. Therefore, the force for fixing the flange 112 is weakened.
  • a large number is preferred.
  • the number of sets may be about 2 to 8 and provided evenly around the cylinder 123.
  • each tube with a stopper is an independent sample storage body, and therefore it is necessary to identify each storage body individually. Therefore, a barcode or two-dimensional code in which various sample data and management information are coded is written on the side surface and bottom surface of the tube 100 with a stopper, and the barcode and the two-dimensional code are read and managed in the management process. Technology to do is necessary.
  • FIG. 6A shows a configuration example in which the color writing film that can be colored by laser marking is attached around the sample storage body 120 on the side surface of the tube body 121 to form the information writing area 127. Information can be written by changing the color of the coloring film by laser marking in the information writing area 127.
  • FIG. 6B a configuration in which an information writing area 128 of the color developing film is provided on the bottom surface 126 of the tube body 120 is also possible. In this configuration example, a one-dimensional code is written in the information writing area 127 of the coloring film on the side surface of the sample body 120, and a two-dimensional code is written in the information writing area 128 of the coloring film on the bottom surface. It shows.
  • the lid 110 is reversibly removed with respect to the mounting operation.
  • the lid 110 is fitted and clamped by the lid fixing portion 122, and only the small lid 110 is moved upward. It is necessary to pull it up with a strong force.
  • the sample holder is pushed up from the top of the lid 110 without opening the lid 110 and the sample storage body. An extraction operation is performed in which an injection needle is inserted into 120 and the sample is sucked.
  • FIG. 7 is a diagram simply showing the state of the take-out operation in which the sample is aspirated from the upper part of the lid 110 without pushing the lid 110, and the needle of the syringe is pushed up.
  • a sample 200 is stored inside the sample storage body 120.
  • the needle 200 or the like of the syringe is protruded from the upper surface to access the sample 200.
  • a seal 114 may be attached to the upper surface thereof.
  • the seal 114 is peeled off. Or may be accessed with the seal 144 attached.
  • FIG. 7 shows a state in which the film seal 114 attached to the upper surface in FIG. 7A is accessed as shown in FIG.
  • the concave portion 113 is provided on the upper surface of the lid 110, the thickness of the portion is thin, so that it is easy to pierce by pushing the injection needle. ing.
  • the sample 200 can be accessed by the injection needle 300, the sample 200 can be aspirated.
  • what is necessary is just to discard the tube 100 with a stopper which completed taking out the sample 200 as what fulfilled the use of sample preservation
  • FIG. 8 is a cross-sectional view illustrating the configuration of the stopper-equipped tubes 100a and 100b according to the second embodiment in an easy-to-understand manner. Similar to FIG. 4 (d), the longitudinal section is a diagram in which a longitudinal section is taken at a place where the overhanging portion is provided.
  • the protruding portion 124a of the lid fixing portion 122a is provided with a taper.
  • the flange 112a of the lid body is easily guided downward, and the deformation of the flange 112a is assisted and the protruding portion is supported. It is easy to pass through the portion 124a and easily fit into the slit portion 125a as shown in FIG.
  • the lid body 110a by the lid body fixing part 122a. The effect of fixing is obtained.
  • the protruding portion 124b of the lid fixing portion 122b is the same as that of the first embodiment, but the taper is formed on the flange 112b side. Is provided.
  • the flange 112b of the lid 110b is tapered, the flange 112b of the lid 110b is easily guided downward, and the flange 112b is also deformed. Assisted and easily passes through the overhanging portion 124b, and easily fits in the slit portion 125b as shown in FIG.
  • a taper is provided on the projecting portion 124 of the lid fixing portion 122 as in the configuration examples of FIGS. 8A to 8C, and FIGS. 8D to 8F.
  • a combination in which the flange 112 of the lid 110 is also tapered as in the configuration example is possible.
  • the point that the upward movement of the flange 112 is braked once the flange 112 fits into the slit portion 125 can be exhibited in the same manner as in FIG.
  • the fixing effect of the lid 110 by the fixing part 122 is obtained.
  • FIG. 9 is a diagram illustrating a configuration example of the tube body 120c of the stopper-equipped tube 100c according to the third embodiment.
  • the portion where the protruding portion 124 and the slit portion 125 that fix the lid 110 are provided is provided on the wall surface near the upper surface of the tube body 120.
  • the lid body 110 is fixed to the upper surface of the tube body 120c.
  • Structures such as the overhanging portion 124c and the slit portion 125c are provided. Looking at the outer wall surface, it appears that an irregular outer wall surface is provided on the cylindrical surface of the tube body 120c.
  • FIG. 2 and FIG. 9 The difference between FIG. 2 and FIG. 9 is only the difference in how far the tube body 120 is viewed, and is common in that the structure of the overhanging portion 124 and the slit portion 125 for fixing the lid 110 is provided near the upper surface. There is no difference between essential and technical thought.
  • the tube with a stopper of the present invention can be widely applied as long as it is a microtube for storing and managing a sample.
  • FIG. It is a figure which shows the structure which attached the color development film which can be colored with a laser marking to the circumference of the sample storage body 120 on the side surface of the tube body 121, and was set as the information writing area
  • FIG. It is a figure which shows simply the mode of the taking-out operation
  • FIG. It is the figure which showed the problem in the prior art microtube array and a prior art.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Closures For Containers (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

Le problème décrit par la présente invention est de pourvoir à un tube pourvu d'un bouchon conçu de façon qu'un corps de couvercle s'insère fermement dans l'ouverture de face supérieure d'un corps destiné à recevoir un échantillon par simple poussée dudit corps de couvercle dans l'ouverture de face supérieure, et de façon que le corps de couvercle inséré ne se déloge pas accidentellement. La solution selon l'invention porte sur un corps destiné à recevoir un échantillon (120) comprenant : un corps de tube (121) dans lequel l'échantillon est reçu ; et une structure qui solidarise un corps de couvercle (110) à la partie supérieure du corps de tube (121), le corps de couvercle (110) comprenant : une partie bouchon (111) qui sert de bouchon quand il est enfoncé dans le corps destiné à recevoir un échantillon ; et une partie bride (112). Le corps de tube (121) comporte une partie présentant une découpe (125) destinée à recevoir et à maintenir partiellement la partie périphérique extérieure de la partie bride (112) quand le corps de couvercle (110) est enfoncé et que le corps de bouchon (111) est inséré dans le corps de tube (121) et vient au contact de sa surface intérieure. Une partie de la partie bride (112) s'insère dans la partie présentant une découpe (125), solidarisant ainsi le corps de couvercle (110) au corps destiné à recevoir un échantillon (120).
PCT/JP2014/055072 2013-03-03 2014-02-28 Tube pourvu d'un bouchon ayant la structure d'un bouchon de type à pousser WO2014136676A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014527404A JP5658849B1 (ja) 2013-03-03 2014-02-28 押し栓構造を備えたストッパー付きチューブ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-041345 2013-03-03
JP2013041345 2013-03-03

Publications (1)

Publication Number Publication Date
WO2014136676A1 true WO2014136676A1 (fr) 2014-09-12

Family

ID=51491195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/055072 WO2014136676A1 (fr) 2013-03-03 2014-02-28 Tube pourvu d'un bouchon ayant la structure d'un bouchon de type à pousser

Country Status (2)

Country Link
JP (1) JP5658849B1 (fr)
WO (1) WO2014136676A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6255538B1 (ja) * 2016-12-19 2017-12-27 神戸バイオロボティクス株式会社 試料収納体
CN109562883A (zh) * 2016-08-11 2019-04-02 仪器实验室公司 双室试剂混合容器
JP2019527339A (ja) * 2016-06-17 2019-09-26 バイオインフラ、カンパニー、リミテッドＢｉｏｉｎｆｒａ Ｃｏ．， Ｌｔｄ． チューブ開閉装置、及びそれを含む分注システム

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102406217B1 (ko) * 2020-06-08 2022-06-07 중앙대학교 산학협력단 응축방지 피씨알 튜브

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05309083A (ja) * 1991-04-18 1993-11-22 Terumo Corp 有底管用密封部材および密封部材付有底管
US20030121878A1 (en) * 2001-12-27 2003-07-03 Finneran James G. Versatile vial and plug system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05309083A (ja) * 1991-04-18 1993-11-22 Terumo Corp 有底管用密封部材および密封部材付有底管
US20030121878A1 (en) * 2001-12-27 2003-07-03 Finneran James G. Versatile vial and plug system

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019527339A (ja) * 2016-06-17 2019-09-26 バイオインフラ、カンパニー、リミテッドＢｉｏｉｎｆｒａ Ｃｏ．， Ｌｔｄ． チューブ開閉装置、及びそれを含む分注システム
US11572263B2 (en) 2016-06-17 2023-02-07 Bioinfra Co., Ltd. Tube opening and closing device and dispensing system including same
CN109562883A (zh) * 2016-08-11 2019-04-02 仪器实验室公司 双室试剂混合容器
JP6255538B1 (ja) * 2016-12-19 2017-12-27 神戸バイオロボティクス株式会社 試料収納体
WO2018116351A1 (fr) * 2016-12-19 2018-06-28 神戸バイオロボティクス株式会社 Récipient à échantillon
US10983030B2 (en) 2016-12-19 2021-04-20 Kobe Bio Robotix Co., Ltd. Sample storage tube

Also Published As

Publication number Publication date
JP5658849B1 (ja) 2015-01-28
JPWO2014136676A1 (ja) 2017-02-09

Similar Documents

Publication Publication Date Title
JP6321884B2 (ja) 試料収納体および試料収納体自動システム
EP2289625B1 (fr) Récipient à échantillons
JP5658849B1 (ja) 押し栓構造を備えたストッパー付きチューブ
CA2641777C (fr) Recipient d'echantillonnage servant a contenir de petites quantites de liquide pour analyses
CN109154624B (zh) 带连结件的试样收纳体
EP2582590B1 (fr) Conteneur comprenant une fermeture et un corps et un procede de stockage d'un echantillon dans le conteneur
US11207692B2 (en) Reagent cartridge
WO2009113694A1 (fr) Contenant de stockage d'échantillon
US8202497B2 (en) Lid element array and a micro tube array for sample storage including the same
JP6013351B2 (ja) 反応容器のアセンブリ、アレイ及びケーシング
US20040226984A1 (en) Tube for storing fluid
US20230052202A1 (en) Cap for a pathogen sample tube
JP2014505856A5 (fr)
JP2005324832A (ja) 試薬容器のキャップ及び試薬の蒸発等の防止法
US20110027150A1 (en) Container for receiving and storing biological material, especially dna
JP2009222443A (ja) データ保存機能を有するテストチューブ
US9475601B2 (en) Devices for containing materials and methods of using and marking same
JP2011153990A (ja) 試薬容器セット及び連結部材
JP5959268B2 (ja) 標本ホルダおよび倒立顕微鏡システム
JP2023543303A (ja) プラスチック製の蓋付容器およびプラスチック製の蓋付容器のマーキング方法
MX2008010089A (en) Sample vessel for accommodating small amounts of liquid for analyses

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2014527404

Country of ref document: JP

Kind code of ref document: A

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14760602

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14760602

Country of ref document: EP

Kind code of ref document: A1