WO2014123225A1 - Composition de partie de tétine de bétail, partie de tétine de bétail, coffret de partie de tétine composite de bétail et procédé pour protéger une tétine de bétail - Google Patents

Composition de partie de tétine de bétail, partie de tétine de bétail, coffret de partie de tétine composite de bétail et procédé pour protéger une tétine de bétail Download PDF

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WO2014123225A1
WO2014123225A1 PCT/JP2014/052924 JP2014052924W WO2014123225A1 WO 2014123225 A1 WO2014123225 A1 WO 2014123225A1 JP 2014052924 W JP2014052924 W JP 2014052924W WO 2014123225 A1 WO2014123225 A1 WO 2014123225A1
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nipple
livestock
pack
water
nipple pack
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PCT/JP2014/052924
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English (en)
Japanese (ja)
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浩司 松重
友康 永沢
峰登 長谷
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株式会社トクヤマデンタル
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Priority claimed from JP2013049491A external-priority patent/JP2014168451A/ja
Priority claimed from JP2013182734A external-priority patent/JP2014195448A/ja
Priority claimed from JP2013264041A external-priority patent/JP2015097522A/ja
Application filed by 株式会社トクヤマデンタル filed Critical 株式会社トクヤマデンタル
Publication of WO2014123225A1 publication Critical patent/WO2014123225A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K13/00—Devices for grooming or caring of animals, e.g. curry-combs; Fetlock rings; Tail-holders; Devices for preventing crib-biting; Washing devices; Protection against weather conditions or insects
    • A01K13/003—Devices for applying insecticides or medication

Definitions

  • the present invention is required for a teat pack that has high film-forming power, good adhesion to livestock teats, does not cause over-curing, has little deformation due to drying, and has excellent elasticity, moisture retention, mechanical strength, etc.
  • Livestock teat packs that can maintain various physical properties for a long time and can be easily peeled off after use, livestock composite teat pack kits, livestock teat packs and livestock composite teat pack kits
  • the present invention relates to a pack composition and a method for protecting a domestic teat using the same.
  • the appropriate dry period varies from individual to individual depending on the order of production, milk yield, delivery interval, maternal growth, physical condition, etc., but the general dry period is 60-65 days for first-time cows, It is 50-55 days for cattle.
  • production diseases such as milk fever and mastitis. Therefore, the management of the dry period is a crucial determinant for the productivity and profitability of dairy cows, and particularly mastitis directly affects milk yield.
  • Mastitis is an infectious disease mainly caused by Staphylococcus aureus, environmental streptococci, coliforms (E.
  • mastitis a disease that cannot be eradicated because of its complicated mechanism of development and continues to cause serious economic losses to the dairy industry.
  • mastitis There are various types and symptoms of mastitis, but it is easy to find mastitis with so-called clinical symptoms such as redness of the breast, pain, swelling, fever or appearance of milk soul in milk. As the treatment spreads, it is decreasing worldwide. However, although these clinical symptoms are not observed, abnormalities such as an increase in the number of somatic cells are discovered when milk is examined. Despite this, its control has not progressed slowly.
  • the measure called “5 points” described above is a measure that should be adopted naturally in dairy management, and even with these measures, it is completely prevented that bacteria and other microorganisms enter the breast from the nipple mouth. It is extremely difficult to do.
  • nipples have been wiped off when milking.
  • a work such as wiping with a wet towel etc. and then wiping with a dry paper towel is common.
  • the bacteria adhering to the teat are sterilized by spraying with a chemical solution such as an antibacterial agent, and mastitis-causing bacteria are prevented from entering the teat after milking.
  • the film-forming power after application is small, and dirt immediately on the bed, manure, etc. tend to adhere to the nipple immediately after resting on the side.
  • Patent Document 1 states, “In dairy cows, during the dry period that is susceptible to mastitis, and before parturition, the nipple is immersed in a nipple sealant and kept in a state in which a thin film that closes the nipple mouth is formed on the nipple. According to claim 1, a method for preventing mastitis in dairy cows is characterized in that the infection of mastitis-causing bacteria is physically blocked.
  • Patent Document 1 discloses a nipple sealant for immersing the nipple mouth, a fluorocarbon substitute such as tetrahydrofuran, acetonitrile, trichloroethane, trichloroethylene, and methylene chloride, and an aromatic compound such as toluene and xylene as a solvent.
  • a fluorocarbon substitute such as tetrahydrofuran, acetonitrile, trichloroethane, trichloroethylene, and methylene chloride
  • an aromatic compound such as toluene and xylene as a solvent.
  • Butadiene resin, polyvinyl alcohol, liquid butyl rubber, liquid rubber, natural rubber, butyl rubber, nitrile rubber, chloroprene rubber, vinyl acetate rubber, etc. are dissolved (paragraphs 0017, 0018, etc.).
  • Patent Document 1 since the rubber-based material of Patent Document 1 has insufficient adhesion to the nipple, it is easy to peel off from the nipple, and it is necessary to prevent infection with mastitis-causing bacteria, for a period of about 2 days to about 9 days, There is a problem that the papillary mouth cannot always be blocked.
  • Patent Document 2 discloses “a teat pack containing at least water, a calcium salt, and an alginate and having a viscosity before gelation of 5,000 to 1,500,000 mPa ⁇ s”. Item 1).
  • the gel of alginate described in Patent Document 2 is rich in flexibility and elasticity, has good adhesion to the nipple, is difficult to peel off from the nipple, and is excellent in occlusiveness of the nipple mouth.
  • the invention disclosed in Patent Document 2 has the following disadvantages. (1) As a solvent, only hydrophilic solvents, such as water, alcohol aqueous solution, glycerol, propylene glycol, and ethyl alcohol, are illustrated.
  • nipple packs As one of the important physical properties required for nipple packs, it has mechanical strength that does not cause breakage due to impact when dairy cows exercise, lie down, rest, etc. in barns, pastures, etc. That is.
  • the teat pack made of an alginate gelled product described in Patent Document 2 is not sufficient in terms of mechanical strength.
  • these teat packs are coated on livestock teats in the form of a water blend of uncured gelling material. Therefore, from the viewpoint of operability at that time, it is desirable to have a low viscosity as in Patent Document 2, and therefore it is preferable to increase the water content.
  • Patent Document 2 states that “the gel strength of the teat pack of the present invention is not particularly defined unless it deviates from the gist of the present invention, but it needs to be strong enough to withstand lying (paragraph 0024)”. It is only described here and does not suggest a specific solution. In particular, there is no description or suggestion regarding the molar ratio (M / G ratio) of ⁇ -D-mannuronic acid (M) to ⁇ -L-guluronic acid (G) constituting the alginate that greatly contributes to gel strength. .
  • the objects of the present invention are (a) high film-forming ability, (b) rich in elasticity as a whole, great adhesion to the surface of the nipple and great follow-up to the shape, and (c) intense livestock such as dairy cows. Has sufficient mechanical strength to withstand impacts such as exercise, recumbency, rest, etc.
  • a livestock nipple pack composition containing at least a polysaccharide polymer electrolyte, a gelling reagent and a poorly water-soluble solvent has a high film-forming ability. It is possible to obtain a gel-like nipple pack for livestock that has good adhesion to the nipple surface of livestock and good conformity to the shape, does not cause over-curing, has little deformation due to drying, and can be easily peeled off after use. discovered. Furthermore, it has been found that the development of this domestic nipple pack satisfies all of the objects of the present invention described above. Therefore, the present invention has been made based on these findings.
  • a composition for forming a gel-like pack that is brought into close contact with a domestic teat comprising at least a polysaccharide polymer electrolyte, a gelling reaction agent, and a poorly water-soluble solvent.
  • the base material paste which has a polysaccharide polymer electrolyte and water as a main component and the hardening material paste which has a gelatinization reaction agent and a slightly water-soluble solvent as a main component are included.
  • the non-reducing sugar is a disaccharide.
  • the disaccharide is trehalose.
  • the polysaccharide polymer electrolyte is an alginate or a derivative thereof.
  • the alginate has an M / G ratio, which is a molar ratio of ⁇ -D mannuronic acid to ⁇ -L gluronic acid, in the range of 0.4 to 0.7.
  • the viscosity (23 ° C.) of a kneaded product obtained by kneading a nipple pack composition for livestock in water is set in the range of 80 to 500 dPa ⁇ s.
  • nipple pack composition for livestock described in any one of 1 to 8 above, and b) i) the nipple pack-coated resin container for coating the gelled product of the nipple pack composition for livestock, or ii) It is composed of a resin curable material for forming the nipple pack-coated resin container, and a composite nipple pack kit for livestock is obtained.
  • the teat pack-covered resin container is formed of natural rubber, synthetic rubber or synthetic resin.
  • the resin curable material for forming the nipple pack-coated resin container is an aqueous emulsion containing natural rubber, synthetic rubber or synthetic resin as a dispersoid and water as a dispersion medium. It is a polymer organic solvent solution in which polymer latex or natural rubber, synthetic rubber or synthetic resin is dissolved in an organic solvent.
  • the water kneaded material kneads the base polymer paste mainly composed of the polysaccharide polymer electrolyte and water, and the hardener paste mainly composed of the gelling reaction agent and the hardly water-soluble solvent. Form.
  • the method for protecting the nipple of livestock is to gel the polysaccharide polymer electrolyte after applying the water blend of the nipple pack composition for livestock described in any one of the above 1 to 8 to the nipple. including.
  • the water kneaded product comprises at least a base paste composed mainly of the polysaccharide polymer electrolyte and water, and a curing material paste composed mainly of the gelling reagent and a hardly water-soluble solvent. It is formed by kneading.
  • the method of protecting livestock nipples using the livestock composite nipple pack kit according to Item 9 includes: b) i) a nipple pack-coated resin container; a) the livestock according to any one of Items 1 to 8 above.
  • the surface of the gel-like nipple pack is filled by filling the nipple pack composition with a water mixture and immersing and gelling the domestic nipple in the filled domestic nipple pack composition.
  • the method of protecting livestock nipples using the livestock composite nipple pack kit according to Item 9 includes the steps of: a) applying the livestock nipple pack composition according to any one of Items 1 to 8 above. A water blend is applied and gelled to form a gel nipple pack, and then b) ii) a resin curable material for forming a nipple pack-coated resin container is applied to the surface of the gel nipple pack. And protecting the domestic nipple with a composite nipple pack in which the surface of the gel nipple pack is covered with a nipple pack-coated resin container.
  • a gel-like teat pack that has high film-forming power, good adhesion to livestock teats, does not cause over-curing, has little deformation due to drying, and can be easily peeled off after use is obtained.
  • the nipple pack of the present invention it is possible to prevent infections such as mastitis in livestock, avoid injury and dirt on the nipple, and the like.
  • the composite nipple pack for livestock according to the present invention is manufactured by gelling a composition containing a polysaccharide polymer electrolyte and a gelling agent by synergistic action of the nipple pack and the nipple pack-coated resin container.
  • a defect of the conventional nipple pack consisting of one layer or the conventional rubber nipple pack consisting of a single layer made of natural or various synthetic rubber latex is improved, and the following physical properties are satisfied.
  • B High adhesion to the nipple surface.
  • C High moisture retention.
  • D Less deformation due to drying.
  • (E) It is rich in elasticity as a whole and has good shape followability to the nipple.
  • F Further, the above physical properties are maintained for a long period of time, particularly in the case of dairy cows, considering the preparation period from non-milking period to milking, etc. for 7 days or more, preferably about 2 weeks. It is also possible to do.
  • G To provide a nipple pack for livestock that can be easily peeled off after use, (H) is simple in work, and has a small physiological burden on workers and livestock.
  • the alginate the one having a molar ratio (M / G) of ⁇ -D mannuronic acid to ⁇ -L guluronic acid constituting the alginate is selected in the range of 0.4 to 0.7, Since it is combined with the gelling reaction agent, a material having mechanical strength that can sufficiently withstand impacts and the like generated after wearing the pack, such as resting on the side, is obtained. In particular, even if the water-mixed product has a high water content and low viscosity, which is excellent in the coverage of livestock nipples, a gelled product having excellent mechanical strength is obtained, and the operability and mechanical strength during coating are obtained. Can be compatible. In addition, it has appropriate elasticity, is excellent in such elasticity and maintainability of the excellent mechanical strength, and can protect the teat for a long time.
  • FIG. 2 is a diagram showing the molecular structure of an MM block composed of ⁇ -D-mannuronic acid (M) continuously bonded.
  • FIG. 2 is a diagram showing the molecular structure of a GG block constituted by continuous binding of ⁇ -L-guluronic acid (G).
  • G ⁇ -L-guluronic acid
  • the present invention provides [a composition for forming a gel-like pack to be in close contact with the nipple of a domestic animal, comprising at least a polysaccharide polymer electrolyte, a gelling reaction agent, and a poorly water-soluble solvent.
  • Nipple pack composition was established as a basic invention, and a method for covering and protecting a domestic nipple with a single layer using this nipple pack composition for livestock (hereinafter, this method is referred to as “single coating method”) was established. Is.
  • the basic invention is further developed, [the nipple pack composition for livestock, and b) i) a nipple pack-coated resin container for coating a gelled product of the nipple pack composition for livestock, or ii) the nipple A resin curable material for forming a pack-coated resin container, and developed into a livestock composite nipple pack kit], and further, a livestock nipple is coated with a composite layer using the livestock composite nipple pack kit -Established a protection method (hereinafter referred to as "double coating method").
  • double coating method hereinafter, the “domestic nipple pack composition”, the “single coating method” using the same, the “livestock compound nipple pack kit”, and the “double coating method” using the same will be described in detail.
  • polysaccharide polymer electrolyte examples include alginic acid or a derivative thereof, cherry, mucopolysaccharide protein (such as hyaluronic acid), sulfonated alkyl cellulose, dextran, carrageenan, and gellan gum.
  • the polysaccharide polymer electrolyte may be a mixture of two or more.
  • alginic acid As the polysaccharide polymer electrolyte, alginic acid or a derivative thereof (hereinafter sometimes simply referred to as “alginic acids”) is preferable.
  • Alginic acid is a linear polymer in which two blocks of ⁇ -D-mannuronic acid (M) and ⁇ -L-guluronic acid (G) are (1-4) -linked, and its derivatives are usually carboxylic acids.
  • M ⁇ -D-mannuronic acid
  • G ⁇ -L-guluronic acid
  • This is a partial reaction product, and examples thereof include alginates, ester derivatives of alginic acid, ether derivatives of alginic acid, and the like.
  • examples of the alginate include alkali metal alginate such as sodium alginate and potassium alginate; ammonium alginate such as ammonium alginate and triethanolamine alginate.
  • examples of the ester derivative of alginic acid include alkylene glycol alginate such as propylene glycol alginate, and examples of the ester derivative of alginic acid include propylene glycol alginate ether.
  • an alginate or a derivative thereof is preferable, an alkali metal alginate is more preferable, sodium alginate and potassium alginate are particularly preferable, and potassium alginate is most preferable from the viewpoint of the strength of the gelled product.
  • Alginic acids can also be used as a mixture of two or more.
  • Alginic acids may be natural products or synthetic products. Typical natural products include Macrocystis on the west coast of the United States, Lessonia in Chile in South America, Ascophyllum in Northern Europe, etc. Any type of seaweed and locality may be used.
  • the extraction method includes an alkali extraction method and a hot water extraction method, but is not particularly defined.
  • the viscosity of the water kneaded product of the present composition prepared to form a gel pack greatly depends not only on the content of alginic acids but also on the molecular weight of alginic acids.
  • potassium alginate is a straight chain in which potassium (K) is bonded to a carboxy group of ⁇ -D-mannuronic acid (M) and a carboxy group of ⁇ -L-guluronic acid (G). It is a polysaccharide polymer, and its molecular weight is usually 20,000 to 250,000.
  • the ionization equilibrium of the —COOK group when potassium alginate is dissolved in water is as follows.
  • Potassium alginate generates four types of ions, —COO ⁇ , K + , H + , and OH ⁇ in the presence of water, and these four types of ions are related to (a), (b), (c) and The four ionization equilibria of (d) are possible.
  • a polyvalent metal ion generated from the gelling agent for example, calcium ion (Ca 2+ )
  • Ca 2+ calcium ion
  • the deprotonated carboxyl group (COO ⁇ ) is ion-bonded to Ca 2+ and 1
  • Two carboxy groups of one repeating unit are ion-bonded with one Ca 2+ as a nucleus, and these GG block chains in the alginate molecule are associated with each other so as to embed calcium ions.
  • a gel with a three-dimensional network structure having an association part (Egg-Box-Junction) is formed.
  • One aspect of the present invention has a mechanical strength that can sufficiently withstand impacts, etc. that occur after wearing the pack, such as when exercising, lying down, resting, etc. among livestock such as dairy cows among the physical properties required for a nipple pack.
  • the water blend is a highly water-containing and low-viscosity product with excellent coverage of livestock nipples, in order to form a gelled product with excellent mechanical strength, as an alginate,
  • the molar ratio (M / G) of ⁇ -D mannuronic acid to ⁇ -L guluronic acid constituting the alginate is selectively used. Therefore, this point will be described in detail.
  • the molar ratio (M / G ratio) of ⁇ -D-mannuronic acid (M) to ⁇ -L-guluronic acid (G) varies depending on the seaweed used as a raw material for alginic acid.
  • the M / G ratio of alginate contained in the raw seaweed is, for example, about 1.3 for Lesesianigrescens, about 0.5 for Lessoniaflavicans, about 1.8 for Macrocystispyrifera, about 1.7 for Eckloniamaxima, about 2 for Laminariajaponica .2, Laminariahyperborean (stem part) about 0.6, Laminariahyperborean (leaf part) about 1.2, Laminariadigitate about 1.2, Durvilleaantarctica about 2.2, Durvilleapotatorum about 2.3, Ascophyllumnodosum about 1 .9.
  • the alginate used for the gelling material for the teat pack material is selected from a wide range of the M / G ratio in a narrow range of 0.4 to 0.7. Is preferably used.
  • the rigidity of the gelled product is improved, so that the resulting teat pack is excellent enough to withstand impacts, etc. that occur after wearing the pack, such as when the cow is resting on the side. It has mechanical strength.
  • the ⁇ -D-mannuronic acid (M) is more than the proportion of the flat MM block (see FIG. 2) constituted by continuous bonding.
  • the ratio of the bowl-shaped GG block (see FIG. 3) constituted by continuous binding of L-guluronic acid (G) becomes relatively large.
  • the alginic acid molecule gels in the presence of calcium ions released from the gelling reagent, the GG block chains in the alginic acid molecules embed calcium ions as illustrated in FIG. It is easy to form a meeting part (Egg-Box-Junction) meeting.
  • the gelled product using the alginate having a low M / G ratio has high rigidity as described above.
  • symbol G means a GG block chain
  • Black circles mean calcium ions.
  • the gelled product becomes rigid, while the elasticity of the gelled product decreases.
  • the gelled material obtained not only has the said outstanding rigidity (mechanical strength), but also becomes excellent also about the elasticity of a gelled material.
  • the reason why the rigidity and elasticity can be compatible in the gelled product by blending the non-reducing sugar is not necessarily clear, but the present inventors presume as follows. That is, non-reducing sugars have high affinity (hydration) with water molecules. Therefore, when the alginate is kneaded with water, the non-reducing sugar is considered to constitute a molecular assembly together with water molecules. The molecular aggregates enter between the molecular chains of the alginate and / or into the molecular chain of the alginate, so that aggregation of these alginate is suppressed, and as a result, the elasticity of the gelled product can be maintained. I think that it will become.
  • the alginate as described above, it is preferable to use an alginate having an M / G ratio in the range of 0.4 to 0.7.
  • the teat pack composition of the present embodiment contains young alginate having an M / G ratio exceeding 0.7 in addition to an alginate having an M / G ratio in the range of 0.4 to 0.7. It may be.
  • the upper limit of the M / G ratio of the alginate is generally about 2.5, and the upper limit can be included.
  • an alginate having an M / G ratio in the range of 0.4 to 0.7 is preferably used as a main component.
  • the M / G ratio with respect to the total amount of an alginate having an M / G ratio in the range of 0.4 to 0.7 and an alginate having an M / G ratio exceeding 0.7 is preferably in the range of 0.4 to 0.7, the alginate content ratio is preferably more than 90% by mass, more preferably 93% by mass or more, and even more preferably 95% by mass or more. preferable.
  • the M / G ratio is 0.4 to
  • the content ratio of the alginate within the range of 0.7 to more than 90% by mass, the mechanical strength of the gelled product can be improved to a more appropriate range.
  • sufficient mechanical strength can be maintained even when the water blend of the livestock nipple pack composition has a high water content and a low viscosity so that the nipples of livestock can be easily coated.
  • the content of alginic acids when the nipple pack composition for livestock is kneaded with water is not particularly limited. Specifically, the content of alginic acids in the kneaded product is as wide as 0.5% by mass to 20% by mass. Can be selected from a range. However, when the above-mentioned specific M / G ratio alginate is used, which provides a gelled product with excellent mechanical strength as alginic acid, the content of alginic acid in the kneaded product is 1% by mass or more and 10% by mass or less. It is preferable to be within the range. By setting the content of alginic acid in the kneaded product to 1% by mass or more, it becomes easy to ensure the strength of the gelled product. Moreover, it becomes easy to ensure the dispersibility at the time of kneading
  • the molecular weight of alginic acids is not particularly limited, but in general, the viscosity measured with a cone plate viscometer of a 23 ° C. aqueous solution containing 1% by weight of alginic acids is within the range of 50 mPa ⁇ sec to 1,000 mPa ⁇ sec. It is preferable to select the molecular weight appropriately depending on the situation.
  • the viscosity indicating the molecular weight of the alginic acids is 80 mPa ⁇ sec to The range is preferably 700 mPa ⁇ sec.
  • the gelling reagent reacts with the polysaccharide polymer electrolyte in the presence of water to form a gel-like pack.
  • a divalent or higher polyvalent metal compound is preferred as the gelling agent. Since the polyvalent metal compound is dissociated to produce a polyvalent metal ion having a valence of 2 or more, it forms a three-dimensional network structure having an ionic bond within or between the molecular chains of the polysaccharide polymer electrolyte.
  • a gelling agent, water, and a poorly water-soluble solvent are mixed and stirred, a kneaded product suitable for forming a gel pack is obtained.
  • polyvalent metal compound examples include (i) calcium sulfate dihydrate, calcium sulfate hemihydrate, calcium sulfate such as anhydrous calcium sulfate, and (ii) sulfuric acid such as calcium chloride, calcium lactate, calcium phosphate, calcium gluconate, and calcium carbonate.
  • the oxide and hydroxide include calcium oxide, magnesium oxide, zinc oxide, titanium oxide, zirconium oxide, tin oxide, calcium hydroxide, magnesium hydroxide, zinc hydroxide, aluminum hydroxide, and hydroxide. Iron etc. are mentioned.
  • These gelation reagents may be a mixture of two or more.
  • the gelling agent is mainly composed of calcium sulfate and a small amount of magnesium oxide and / or zinc oxide. Is preferred.
  • the blending ratio of magnesium oxide and / or zinc oxide is preferably 2 to 40 parts by mass with respect to 100 parts by mass of calcium sulfate.
  • the blending amount of the gelling agent is not particularly limited, but is preferably in the range of 10 parts by weight to 2,000 parts by weight, and in the range of 100 parts by weight to 1,000 parts by weight with respect to 100 parts by weight of the polysaccharide polymer electrolyte. More preferred.
  • the calcium ion is preferably in the range of 100 to 40,000 mol, and in the range of 250 to 30,000 mol, per mol of alginic acid. More preferably.
  • a poorly water-soluble solvent is a gel that forms a gel pack on the nipple and then excessively crosslinks the polysaccharide polyelectrolyte that comes into contact with the nipple mouth due to calcium ions oozing out from the nipple mouth. Curing can be prevented. This is presumably because when the water blend of the nipple pack composition for livestock is cured, the poorly water-soluble solvent is phase-separated and oozes out on the surface of the gelled product to form a hydrophobic film.
  • “slightly water-soluble solvent” means a solvent having a solubility in 1 L of water at a temperature of 20 ° C. of 0.5 mg or less.
  • the solubility is preferably 0.4 mg or less.
  • a hardly water-soluble organic solvent is preferable.
  • known organic solvents can be used as long as they are organic solvents exhibiting the above-mentioned solubility. Examples of such an organic solvent include hydrocarbon compounds, aliphatic alcohols, cyclic alcohols, fatty acids, fatty acid salts, fatty acid esters, and hydrophobic polymers.
  • the poorly water-soluble organic solvent may be a mixture of two or more. Hereinafter, suitable examples of these various poorly water-soluble organic solvents will be shown.
  • hydrocarbon compound either a chain compound or a cyclic compound can be used. 6 or more are preferable, as for carbon number of a hydrocarbon compound, 8 or more are more preferable, and 10 or more are especially preferable. At least a part of the hydrogen atoms of the hydrocarbon compound may be substituted with a halogen atom such as a fluorine atom.
  • hydrocarbon compounds having 6 or more carbon atoms include aliphatic chain carbonization such as hexane, heptane, octane, nonane, decane, undecane, dodecane, tridecane, tetradecane, pentadecane, kerosene, 2,7-dimethyloctane, and 1-octene.
  • aliphatic chain carbonization such as hexane, heptane, octane, nonane, decane, undecane, dodecane, tridecane, tetradecane, pentadecane, kerosene, 2,7-dimethyloctane, and 1-octene.
  • alicyclic hydrocarbon compounds such as hydrogen compounds, cycloheptane and cyclononane, and liquid paraffin which is a mixture of liquid saturated hydrocarbons.
  • the liquid paraffin may be normal paraffin, isoparaffin, cycloparaffin, or a mixture thereof.
  • the liquid paraffin a commercially available mixture mainly composed of normal paraffin, isoparaffin and monocyclic cycloparaffin obtained by highly purifying a relatively light lubricating oil component by washing with sulfuric acid or the like can be used. Including those called light liquid paraffin in the pharmacopoeia).
  • it has passed at least one of the liquid paraffin purity test in the Japanese Pharmacopoeia, the liquid paraffin purity test in the Japanese food additive standards, and the liquid paraffin purity test in the cosmetic ingredient standards. It is suitable in terms of work / hygiene and safety for livestock.
  • the carbon number of the aliphatic alcohol is preferably 6 or more, more preferably 8 or more, and particularly preferably 10 or more. At least a part of the hydrogen atoms of the aliphatic alcohol may be substituted with a halogen atom such as a fluorine atom.
  • a halogen atom such as a fluorine atom.
  • the aliphatic alcohol having 6 or more carbon atoms include saturated aliphatic alcohols such as 1-hexanol, 1-octanol and tridecanol, and unsaturated aliphatic alcohols such as citronellol and oleyl alcohol.
  • the number of carbon atoms of the cyclic alcohol is preferably 6 or more.
  • At least a part of the hydrogen atoms of the cyclic alcohol may be substituted with a halogen atom such as a fluorine atom.
  • a halogen atom such as a fluorine atom.
  • the cyclic alcohol having 6 or more carbon atoms include benzyl alcohol and meta-cresol.
  • the number of carbon atoms of the fatty acid, fatty acid salt and fatty acid ester is preferably 6 or more, more preferably 8 or more, and particularly preferably 10 or more. At least some of the hydrogen atoms of these compounds may be substituted with a halogen atom such as a fluorine atom.
  • the fatty acid having 6 or more carbon atoms include saturated fatty acids such as hexanoic acid and octanoic acid, and unsaturated fatty acids such as oleic acid and linoleic acid.
  • fatty acid ester having 6 or more carbon atoms examples include vegetable oils such as ethyl octoate, butyl phthalate, glyceryl oleate, olive oil and sesame oil, and animal fats such as liver oil and whale oil.
  • Examples of the solvent composed of a hydrophobic polymer include a relatively low molecular weight organosilicon compound.
  • a relatively low molecular weight organosilicon compound a so-called polysiloxane (also known as silicone oil) has a main skeleton composed of polysiloxane, and an organic group is bonded to each silicon atom of the main skeleton to form side chains and terminals. And a part of the side chain and terminal may be hydrogen).
  • Examples of the polysiloxane (silicone oil) include polydimethylsiloxane, polymethylphenylsiloxane, polymethylhydrogensiloxane, polyphenylhydrogensiloxane, and the like.
  • polysiloxanes having an atomic ratio of carbon atoms to silicon atoms in the molecule (C / Si atomic ratio) of 2 or more are particularly excellent in hydrophobicity.
  • a polysiloxane introduced with a halogenated alkyl group such as a fluoroalkyl group may be used in order to obtain a higher degree of hydrophobicity.
  • hydrocarbon compounds and hydrophobic polymers are more preferable, and liquid paraffin and silicone oil are particularly preferable.
  • those having a high boiling point are preferable. This boiling point is preferably 100 ° C. or more at 1 atm, and more preferably 150 to 600 ° C.
  • the poorly water-soluble organic solvent having a boiling point of 100 ° C. or higher include octane, nonane, decane, 1-hexanol, tridecanol, oleic glyceride, liquid paraffin, and silicone oil.
  • the blending amount of the hardly water-soluble solvent is not particularly limited, but is generally preferably in the range of 1 part by weight to 2,000 parts by weight with respect to 100 parts by weight of the gelling reagent, and 20 parts by weight to 200 parts by weight. A range is more preferred.
  • water elutes polyvalent metal ions such as calcium ions from the gelling reaction agent promotes the reaction between the gelation reaction agent and the polysaccharide polymer electrolyte, and holds the pack in a gel form. It has a function. Tap water, ion exchange water, distilled water, etc. can be used for the water.
  • the amount of water in the kneaded product is preferably in the range of 100 parts by mass to 7,000 parts by mass with respect to 100 parts by mass of the polysaccharide polymer electrolyte.
  • the range of 500 to 5,000 parts by mass is more preferable from the viewpoint of making the water blend of the domestic nipple pack composition low in viscosity so that it can be easily coated on the nipples of domestic animals.
  • Water is generally blended as a liquid component when the nipple pack composition for livestock is a powder type, and is blended as a base paste component when the paste type is a paste type.
  • the powder type it is not always necessary to prepare in advance a liquid material mainly composed of water and a hardly water-soluble solvent, and water may be appropriately added at the time of preparing the water blend.
  • Non-reducing sugar in the nipple pack composition for livestock in the present invention by adding non-reducing sugar, shrinkage and deformation at the time of curing are further reduced, adhesion to the teat is higher, and even when used for a long time, it is dry. It is preferable to form a gel-like pack with less deformation.
  • non-reducing sugar any known sugar that does not exhibit reducing properties can be used without particular limitation.
  • “reducing” means a property that exhibits a reducing action on heavy metal ions such as silver and copper in an alkaline aqueous solution.
  • the reducing saccharide is detected by a Torens reagent, a benecto reagent, or a Fering reagent that uses a reducing action on heavy metal ions.
  • non-reducing sugar means a saccharide that cannot be detected by these reagents.
  • non-reducing sugar As the non-reducing sugar exhibiting the above-mentioned characteristics, known non-reducing sugars such as disaccharides such as trehalose and sucrose, oligosaccharides such as raffinose, melezitose, stachyose, and cyclodextrins can be used. However, when the molecular weight of the non-reducing sugar is too large, the polysaccharide polymer electrolyte and the non-reducing sugar may form a hydrogen bond and aggregate. Therefore, as the non-reducing sugar, a sugar composed of 2 to 10 monosaccharide molecules linked by glycosidic bonds is preferable, and a disaccharide is more preferable.
  • disaccharides such as trehalose and sucrose
  • oligosaccharides such as raffinose, melezitose, stachyose, and cyclodextrins
  • a sugar composed of 2 to 10 monosaccharide molecules linked by glycosidic bonds is prefer
  • trehalose is particularly preferable among disaccharides from the viewpoint of molding accuracy and moisture retention.
  • the blending amount of the non-reducing sugar is not particularly limited, but is preferably in the range of 100 parts by mass to 2,000 parts by mass with respect to 100 parts by mass of the polysaccharide polymer electrolyte from the viewpoint of moisture retention. It is particularly preferred that the content be in the range of 1 part by mass to 1,200 parts by mass.
  • additives can be blended in the nipple pack composition for livestock of the present invention as necessary.
  • additives include gelation modifiers, fillers, inorganic fluorine compounds (potassium fluorotitanate, potassium silicofluoride, etc.), amino acid compounds (amino acid / formaldehyde condensates, etc.), unsaturated carboxylic acid polymers (water kneading)
  • surfactants for example, surfactants, fragrances, coloring agents, antibacterial agents, preservatives, pH adjusters, solvents, and trace adjustment materials.
  • typical additives will be described.
  • the thixotropy of the water blend is further improved. That is, the water kneaded product to which the surfactant is added has a property that when applied to the nipple of a domestic animal, it fits finely into the shape of the nipple due to sufficient fluidity and is difficult to drip after application. Therefore, the adhesiveness with respect to the teat of the gel-like pack containing surfactant is very excellent.
  • the surfactant effects such as improvement of kneadability and easy preparation of a paste type curing material paste can be obtained.
  • the surfactant a known one can be used without particular limitation, and any of an anionic surfactant, a cationic surfactant, an amphoteric surfactant and a nonionic surfactant can be used. These can be used alone or in combination of two or more.
  • anionic surfactant examples include alkyl sulfonates, alkyl benzene sulfonates, and alkyl ether carboxylates.
  • examples of the cationic surfactant include alkylamine salts and quaternary ammonium salts.
  • amphoteric surfactants include aminocarboxylates.
  • Nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene-polyoxypropylene block polymer, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyglycerin. Examples include fatty acid esters, sorbitan fatty acid esters, sucrose esters, polyoxydiethylene alkylamines, block polymers of polysiloxanes and polyoxyethylenes, and the like.
  • a nonionic surfactant is preferable, and a polyglycerol fatty acid ester is more preferable.
  • Polyglycerin fatty acid ester is obtained by subjecting polyglycerin and fatty acid to an esterification reaction in a conventional manner at 1: 1 to 1: 4, and a part of the hydroxyl group of polyglycerin is ester-bonded to fatty acid. The thing which has a compound as a main component is mentioned.
  • fatty acid forming the ester examples include those having 8 to 18 carbon atoms such as lauric acid, myristic acid, stearic acid, and oleic acid, and these can be used alone or as a mixture of two or more.
  • polyglycerin fatty acid esters examples include decaglyceryl trioleate.
  • the blending amount of the surfactant is not particularly limited, but is preferably in the range of 1 to 50 parts by mass with respect to 100 parts by mass of the gelling reagent, and preferably in the range of 3 to 20 parts by mass. More preferred.
  • gelation modifiers generally, (i) phosphates containing alkali metals such as trisodium phosphate, tripotassium phosphate, sodium pyrophosphate, sodium tripolyphosphate, (ii) sodium oxalate, potassium oxalate And (iii) carbonates containing alkali metals such as sodium carbonate and potassium carbonate.
  • the gelation modifier may be a mixture of two or more.
  • the blending amount of the gelling modifier can be appropriately selected according to other blending components and required curing time, but is preferably in the range of 1 to 30 parts by mass with respect to 100 parts by mass of the polysaccharide polymer electrolyte. The range of 3 to 15 parts by mass is more preferable.
  • a filler (curing aid) to adjust the physical properties of the gel pack.
  • the filler it is preferable to use viscous minerals such as diatomaceous earth and talc, and metal or semi-metal oxides such as silica and alumina can also be used.
  • the blending amount of the filler is not particularly limited, but is preferably in the range of 50 parts by weight to 2,000 parts by weight, more preferably in the range of 100 parts by weight to 1,000 parts by weight with respect to 100 parts by weight of the polysaccharide polymer electrolyte. .
  • the domestic teat pack of the present invention may contain an antibacterial agent.
  • antibacterial agents include silver, copper, zinc and other metal salts, iodine, tea leaf powder, hinoki powder and chitosan, and metal salts and / or iodine are more preferred, zinc oxide, titanium oxide, At least one of iron oxide and iodine is more preferable, and zinc oxide and / or iodine is most preferable.
  • An antimicrobial agent can be used individually or in combination of 2 or more types. In particular, by using iodine and another antibacterial agent in combination, a further excellent antibacterial action can be obtained.
  • the compounding amount of the antibacterial agent is preferably 0.1 to 1,000 parts by mass with respect to 100 parts by mass of the polysaccharide polymer electrolyte.
  • the amount is preferably 10 to 500 parts by mass, more preferably 50 to 400 parts by mass, and most preferably 100 to 300 parts by mass with respect to 100 parts by mass of the polysaccharide polymer electrolyte.
  • the effective iodine concentration is preferably 0.1 to 10 parts by mass with respect to 100 parts by mass of the polysaccharide polymer electrolyte based on the nipple pack composition for livestock.
  • the nipple pack for livestock of the present invention can be blended with a water-soluble solvent as long as it does not impair the over-curing suppression effect of the polysaccharide polymer electrolyte that comes into contact with the nipple mouth by the poorly water-soluble solvent.
  • a water-soluble solvent By blending a water-soluble solvent, the dispersibility of hydrophobic solids such as calcium sulfate in water and water retention are improved, and the elasticity after curing of the pack material tends to be maintained longer.
  • a known solvent having a property that the solubility in water at 20 ° C. is 20 g / 100 ml or more can be used without any limitation.
  • the blending amount of the water-soluble solvent is not particularly limited as long as the effect of the present invention is not impaired, but is preferably in the range of 1 to 20% by mass, based on the total amount of the nipple pack composition for livestock, as 5 to 10% by mass. It is more preferable that it is in the range.
  • Powder Type A nipple pack composition for livestock of a powder type includes a powder material mainly composed of a polysaccharide polymer electrolyte and a gelling reaction agent, and a liquid material mainly composed of water and a hardly water-soluble solvent.
  • Other additives non-reducing sugars, surfactants, gelling modifiers, fillers, antibacterial agents, and other additives
  • the powder material can be prepared uniformly and without unevenness by mixing and stirring the components in any order.
  • the liquid material can be prepared by dispersing and dissolving each component in an arbitrary order. The blending ratio of each component in the powder type may be as described above.
  • Paste type 2-1 Composition of base paste and hardener base Paste-type nipple pack composition for livestock consists of a base paste mainly composed of polysaccharide polymer electrolyte and water, a gelling reagent and a poorly water-soluble solvent. And a curing material paste.
  • the gelling reaction agent cures when it reacts with water, the gelation reaction agent can be stably stored in a paste state for a long time by mixing a poorly water-soluble solvent with the gelation reaction agent.
  • non-reducing sugars can be used depending on their physical properties and form (solid, liquid, etc.) What is necessary is just to mix with a base-material paste and / or a hardening material paste.
  • the non-reducing sugar and the water-soluble solvent are preferably blended in the base paste.
  • the filler is preferably added to both the base paste and the curing agent paste, and the gelling regulator, surfactant, potassium fluoride titanate, celite and the like are preferably added to the curing agent paste.
  • the base paste may contain a fragrance, a minute amount adjusting material, and the like.
  • the mixing ratio of each component in the paste type may be determined in consideration of the mixing ratio of each paste so that each component is in the above range after the base paste and the curing material paste are mixed.
  • the polysaccharide polymer electrolyte in the base paste has a large contribution to the viscosity, and the aqueous solution tends to have a high viscosity. Therefore, in order to adjust the viscosity to be easy to handle, it is necessary to have a high water content.
  • the blending ratio is 20 to 95% by mass, preferably 30 to 95% by mass, based on 100% by mass of the base paste.
  • the viscosity (23 ° C.) of the base paste is a value measured with a cone plate viscometer, and is preferably in the range of 50 to 1,500 dPa ⁇ s, and the base paste is easily coated on the domestic teat. From the viewpoint of reducing the viscosity of the water kneaded material mixed with the hardener paste, it is more preferably in the range of 80 to 1,200 dPa ⁇ s. In particular, when the specific M / G ratio alginate is used, a gelled product having excellent mechanical strength can be obtained as a polysaccharide polymer electrolyte, and the water kneaded product can have both coating properties and mechanical strength.
  • the range of 80 to 500 dPa ⁇ s is most preferable.
  • the viscosity (23 ° C.) of the curing material paste is a value measured with a cone plate viscometer, preferably in the range of 50 to 1,800 dPa ⁇ s, and in the range of 80 to 1,500 dPa ⁇ s. Is more preferable.
  • the range of 80 to 500 dPa ⁇ s is most preferable from the viewpoint of achieving both coating properties and the mechanical strength of the gelled product.
  • the viscosities of the above-mentioned hardener paste and base paste, and further the water blend of the nipple pack composition for livestock are values determined as follows.
  • Paste kneading apparatus for kneading base paste and hardener paste Hereinafter, a paste kneading apparatus for kneading base paste and hardener paste will be described.
  • the base paste and the curing material paste can each be prepared by using the above-described constituent components using a known stirrer / mixer.
  • agitator / mixer for example, a general agitator with agitating blades; a rotating container type mixing kneader such as a ball mill; a ribbon mixer, a kneader, an internal mixer, a screw kneader, a Henschel mixer, a universal mixer, a Ladige mixer,
  • a fixed container type mixer / kneader having a horizontal axis or a vertical axis, such as a butterfly mixer or a planetary mixer, can be used.
  • the base paste after performing the first step of dissolving a component having a relatively high solubility in water such as a non-reducing sugar, subsequently, such as a polysaccharide polymer electrolyte
  • a post-process that dissolves components that are relatively poorly soluble in water, either sequentially or in batches
  • strong shear is applied to the component to be dissolved and the solution in which this component is dissolved.
  • a stirrer in which no force is applied.
  • a portable stirrer having the various stirrer blades, the same stirrer, the same side stirrer, a pipe stirrer, or the like can be used.
  • two or more kinds of the above-mentioned various stirring / mixing machines can be used in combination.
  • the paste kneading device includes a first sealed container 1 for base paste, a second sealed container 2 for hardener paste, a pump P1 driven by a motor M1 to feed the base paste, and a motor M2.
  • the kneading means 3 is driven by a motor M, and has a stirring unit for kneading the base paste and the hardener paste, and a portion for discharging the obtained mixed paste.
  • “Tokuyama AP Mixer III” (trade name: Tokuyama Dental Co., Ltd.) commercially available for dental impression materials can be used.
  • JP-A-2001-112785, JP-A-6-57422, JP-A-61246, JP-A-6-18684, JP-A-2000-140600, and JP-A-2001-299778 describe their mechanisms, operating methods, etc. Since the peripheral technology is described, a detailed description thereof will be omitted here.
  • These published patents and utility models are inventions of Tokuyama Corporation (former trade name Tokuyama Soda), a company closely related to the applicant of the present application.
  • Paste kneading device-2 for kneading base paste and hardener paste As a paste kneading device for kneading the base paste and the hardener paste, a portable kneading device that can be moved to any place of use other than the above-described installation type device schematically shown in FIG. It can also be used. As a typical portable paste kneading device, described in “Painting device including a blending device and a multi-component injector” described in Japanese Patent No. 4916440, or described in JP-T-2010-521384. The “dispensing assembly with removably attachable accessories” can be illustrated.
  • the above-described installation type apparatus uses a pump driven by a motor to discharge the base paste and the hardener paste from the containers filled with the base paste and the hardener paste, and further kneads the base paste and the hardener paste.
  • the kneading means is a mechanism driven by a motor, which is a kind of precision instrument. Therefore, the installation type paste kneading apparatus can be used without any problem in a use environment where the apparatus is constantly cleaned and the apparatus itself is thoroughly maintained and inspected like a dental hospital.
  • the environment for carrying out the present invention is not necessarily an environment suitable for using an installation type paste kneading device mainly in a livestock barn or a pasture.
  • the device described in the patent publication includes a cartridge for individually injecting a plurality of components having different compositions and physical properties, and each component is not driven by a motor via a handle and a trigger. It is a mechanism that mixes and discharges by machine drive. Therefore, considering the advantages that the mechanism is simple, maintenance management is easy, the motor drive part is not required, the power supply is unnecessary, and the mobile environment is not constrained by the use environment, the base material in the present invention. It is suitable for a paste kneading apparatus for kneading paste and hardener paste. In addition, since the mechanism, the operation method, etc. are described in the said patent gazette, it abbreviate
  • the paste type teat pack material is usually provided to users such as dairy farmers in a form in which both the base paste and the hardener paste are hermetically stored in a packaging container such as an aluminum pack.
  • a packaging container such as an aluminum pack.
  • the opening of the packaging container of the base paste is used for the base material of “Tokuyama AP Mixer III” (trade name: Tokuyama Dental Co., Ltd.), which is commercially available, for example, for dental impression materials. It connects with a paste injection port, and connects the opening part of the packaging container of hardening material paste to the hardening material paste injection port of the said kneading apparatus.
  • the mixing ratio Rm of the hardener paste to the base paste is particularly high. Although not limited, it is usually preferably within the range of 1 to 4.
  • the nipple pack for livestock is prepared by preparing a water blend containing at least a polysaccharide polymer electrolyte, a gelling reagent, and a poorly water-soluble solvent, and applying the obtained water blend to a nipple of a domestic animal. It is formed by gelling the electrolyte.
  • the nipple pack for livestock formed in this way can be used as a single layer to cover and protect the nipple of livestock, to prevent infections such as mastitis in livestock, and to avoid injury and dirt on the nipple. Also good (single coating method).
  • a water kneaded material adjustment step (b) a coating step, and (c) a gelation step will be described in detail.
  • the water kneaded product is prepared by kneading the base paste and the hardener paste so as not to contain bubbles. If necessary, kneading may be performed using a known stirrer / mixer as described above. However, the paste kneading apparatus described above, for example, “Tokuyama AP Mixer III” commercially available for use in dental impression materials. "(Trade name: Tokuyama Dental Co., Ltd.) is preferred.
  • the water blend obtained by the said process (I) is apply
  • the application method include a dipping method, a brush coating method, and a spraying method, but are not particularly limited. The dipping method is preferred.
  • the viscosity of the water blend in the case of using an immersion method so that a teat may be easily immersed in a water blend.
  • the viscosity of the water kneaded product when using the dipping method is preferably in the range of 80 to 1,200 dPa ⁇ s as described above.
  • a specific M / G ratio alginate is used as the polysaccharide polymer electrolyte. The most preferable range is 80 to 500 dPa ⁇ s.
  • the viscosity (23 ° C.) of the water blend when using the spraying method is more preferably in the range of 50 to 400 dPa ⁇ s in view of ease of spraying, and the viscosity (23 ° C.) of the curing material paste is 50 to More preferably, it is in the range of 400 dPa ⁇ s.
  • the dipping method When using the dipping method, for example, put a water blend into a cylindrical or cup-shaped container that can hold a domestic teat, move the container toward the base of the teat (pull up), and place the teat on the water blend in the container. After soaking, the container is moved (pulled down) toward the tip of the nipple. The soaking may be performed so that the teat length is 100% and 90% or more, preferably about 95%, of the teat is soaked in the water blend on the basis of the length.
  • the material is not limited, and any of metal, ceramic, plastic, paper, etc. can be used.
  • the container should just have the minimum internal volume required in order to make a water kneaded material adhere to a teat in order to reduce the waste of a water kneaded material.
  • a cylindrical or cup-shaped container one having an inner diameter of about 4 cm to about 6 cm and a height of about 5 cm to about 10 cm can be used. It is convenient to have a mark on the inside of the container that can accommodate an appropriate amount of water blend.
  • the dipping is preferably started immediately after the preparation of the water kneaded product.
  • the time for immersing the nipple in the water blend is the initial curing time of the water blend (the gelation modifier described above)
  • the time until the inflection point at which the viscosity, which has been gradually increasing due to the action of the first, begins to increase rapidly upon the start of full-scale curing, is measured in accordance with JIST6505, preferably 20 to 130 seconds. .) Is preferable.
  • the speed at which the container is moved in the direction of the tip of the nipple after dipping is preferably 10 to 100 mm / second, and preferably 20 to 50 mm / second. More preferred.
  • the time required for gelation is preferably 1 to 10 minutes, more preferably 2 to 8 minutes.
  • the time required for gelation can be adjusted by selecting the mixing ratio of the base paste and the curing material paste, the addition amount of the gelling modifier, and the stirring force when kneading both pastes.
  • the “stirring power” means [maximum output (W) of motor of stirrer / amount of mixture of base paste and hardener paste (substantially inner volume of casing of stirrer) (L)] ⁇ ( Actual rotation speed / maximum rotation speed).
  • the curing time of the water blend becomes slower as the stirring force is lowered, and vice versa. In this way, a gel-like pack having high elasticity and excellent adhesion is formed from the water kneaded material adhering to the nipple.
  • the gel strength of the domestic nipple pack is not particularly determined unless it deviates from the gist of the present invention, but it needs to be strong enough to withstand livestock lying down.
  • the elastic strain represented by the height value (mm) is preferably 10 to 20%, and more preferably 12 to 15%.
  • the thickness of the nipple pack is preferably 0.1 mm to 5 mm, more preferably 0.5 mm to 3.5 mm. By setting it as such thickness, the teat pack which shows the effect of this invention more notably is obtained.
  • the teat pack of the present invention is wrapped in a cloth soaked with emulsion (freshly squeezed raw milk) and kept at 25 ° C. for 24 hours.
  • the volume change is 1.5% or less, preferably 1% or less.
  • the nipple pack usually retains its adhesion and elasticity for at least about 1-2 days, preferably about 3-5 days after sealing the nipple. After its use, it may be peeled off in the form of a gel.
  • the gelled product obtained from the nipple pack composition for livestock described in A above is used not only as a single layer, but also as a composite layer by covering the surface with a nipple pack-coated resin container to protect the nipple of livestock. You may use for.
  • a nipple pack-coated resin container maintains the moisture retaining property of the gel nipple pack accommodated in close contact, and has physical properties that closely adhere to the gel nipple pack accommodated and follow the elastic deformation of the gel nipple pack. It is preferable that the farmer possesses enough toughness so as not to be damaged regardless of the posture of the livestock in the barn or pasture, or whatever exercise.
  • the nipple pack composition for livestock described in A above is used as a) member, and as b) member, i) nipple pack coating for coating the gelated product of the domestic nipple pack composition.
  • a composite nipple pack kit for livestock that combines a resin container, or ii) a resin curable material for forming the nipple pack-coated resin container.
  • the resin curable material for forming the nipple pack resin container is a polymer latex composed of a water-based emulsion using natural rubber, synthetic rubber or synthetic resin as a dispersoid and water as a dispersion medium, as described below, or An organic solvent solution in which natural rubber, synthetic rubber or synthetic resin is dissolved in an organic solvent is desirable.
  • Polymer Latex Polymer latex is a name originally given to milky white water-based emulsions extracted from natural rubber trees. Normally, latex refers to natural rubber latex. However, colloidal sols using synthetic rubber or synthetic resin as a dispersoid and various organic or inorganic water solutions as dispersion media are also called latex. Synthetic rubber aqueous dispersions produced using the emulsion polymerization method are called synthetic rubber latex and sometimes distinguished from natural rubber latex. Emulsions of resins other than rubber are also called resin latex and rubber latex. Sometimes it is distinguished. However, in recent years, the term “polymer latex” has been used as a term encompassing all of natural rubber latex, synthetic rubber latex and resin latex.
  • polymer latex is used in that sense (Soichi Muroi: Chemistry of Polymer Latex, Polymer Publishing Association (1976)). However, in the following description of “polymer latex”, it will be classified into natural rubber latex, synthetic rubber latex and synthetic resin latex.
  • Natural rubber latex The natural rubber latex used in the present invention includes a versatile purified latex. That is, it contains water and linear stereoregular cis-1,4-polyisoprene rubber as a main component, the solid content is about 62%, the rubber content is about 60%, the average molecular weight is 5 ⁇ 10 5 , rubber Is a stable spherical colloidal particle having a particle size of 50 to 1300 nm.
  • the most common concentrated latex is a high ammonia latex (HA latex) with 0.7% ammonia added and a low ammonia content with 0.2% ammonia added as a secondary additive and a small amount of secondary additive.
  • HA latex high ammonia latex
  • LA-SPP ammonia SPP
  • LA-BA to which boric acid is added
  • LA-ZDC to which zinc dithiocarbamate is added
  • LA-TZ tetramethyl disulfide and zinc oxide are added, and the like.
  • These are preferably used in the present invention because they have good storage stability, high wet gel strength, high strength of the dry film, high elongation and high elasticity compared to synthetic rubber latex.
  • the vulcanized rubber latex only needs to be formed into a film and does not require a vulcanization process, so the workability is excellent, and the film has a large protein removal effect by leaching, and it is a viewpoint for countermeasures against latex allergy. Is also preferable.
  • the vulcanized rubber latex includes those pre-vulcanized by sulfur crosslinking and those crosslinked by radiation.
  • the radiation-crosslinked latex is produced by adding n-butyl acrylate and irradiating ⁇ rays or electron beams.
  • deproteinized natural rubber latex can be used.
  • Deproteinized natural rubber latex has been developed as a raw material for latex allergy prevention and can be used substantially as a raw material for allergy-free products.
  • all proteins including those bound to rubber molecules are decomposed and removed, and the stability as a latex is maintained by a surfactant. Therefore, the properties as latex are the same as those of synthetic rubber latex, there is little change with time, and the stability is excellent.
  • the natural rubber inherently excellent strength characteristics are maintained, which is preferable in terms of more flexibility and less odor and coloring.
  • JISK6381 describes the test methods and quality standards for natural rubber latex. JISK6381 was created with reference to ASTM D1076 in principle. At present, various types of natural rubber latex are available from the market. Accordingly, it is possible to select a natural rubber latex of a grade suitable for the purpose of use from satisfying the provisions of JISK6381.
  • Synthetic rubber latex In the case of synthetic rubber, emulsion polymerization can be obtained in the form of latex. However, in the case of solution polymerization or bulk polymerization, it can be obtained as a solution or a solid, and in that case, it must be emulsified and converted into an emulsion state. In such a case, it may be called an emulsion instead of latex, but in the present invention, a synthetic rubber produced by solution polymerization or bulk polymerization is also included in the concept of latex. Currently, a wide variety of synthetic rubber latex is available from the market. The typical synthetic rubber latex that can be used in the present invention is exemplified.
  • SBR styrene / butadiene rubber latex
  • JISK6392 specifies a test method for nitrile rubber latex. Therefore, it is preferable to select a nitrile rubber latex suitable for the purpose of use, from among the requirements of JISK6392.
  • chloroprene rubber latex This is the oldest rubber in synthetic rubber, and its test method is defined in JISK6393. It is preferable to select a chloroprene rubber latex that meets the purpose of use from among the requirements.
  • rubber latex usable in the present invention is exemplified by acrylonitrile / butadiene rubber latex, rubber-like acrylic polymer latex, stereoregular polybutadiene rubber latex, stereoregular polyisoprene rubber latex, There are various types such as ethylene-propylene elastomer latex, methyl methacrylate / butadiene copolymer latex, butyl (isobutyl-isoprene) rubber latex, chlorosulfonated polyethylene rubber latex, polyurethane rubber latex, epichlorohydrin rubber rubber, and silicone rubber latex.
  • a reactive functional group such as a carboxyl group, a hydroxyl group, a sulfate group, an amine, an amide, or an N-methylolamide group can be added to these synthetic latexes in a small amount of 5 mol% or less.
  • Synthetic resin-based latex Typical synthetic resin-based latex that can be used in the present invention is polyvinyl chloride latex, vinyl acetate-butyl acrylate copolymer latex, styrene-butyl acrylate copolymer latex, anionic vinyl acetate-butyl acrylate copolymer Polymer latex, polymethacrylate latex, methyl methacrylate-ethyl acrylate copolymer latex, polybutyl methacrylate latex, styrene-butadiene copolymer latex, carboxylated polystyrene latex, anionic vinylidene chloride-vinyl chloride copolymer latex, vinylidene chloride Polymer latex and the like.
  • vulcanizing agents When using commercially available natural rubber or synthetic rubber latex, vulcanizing agents, vulcanization accelerators, vulcanization acceleration aids and vulcanization retarders, deterioration inhibitors (antioxidants, ozone Inhibitors, etc.), processing aids (plasticizers, softeners, tackifiers, etc.), reinforcing fillers, etc. are blended with almost the same additives as those used for solid rubber, but the latex was dispersed in water.
  • dispersants because it is handled as a colloidal solution, depending on the purpose, dispersants, thickeners, stabilizers (anionic, cationic, amphoteric, nonionic surfactants), creaming agents, tanning agents, coagulants (acids), It is necessary to blend a gelling reagent (calcium nitrate, ammonium nitrate, calcium sulfate, etc.), a heat sensitive agent (zinc ammonium complex salt, polyvinyl methyl ether, etc.) and the like.
  • a gelling reagent calcium nitrate, ammonium nitrate, calcium sulfate, etc.
  • a heat sensitive agent zinc ammonium complex salt, polyvinyl methyl ether, etc.
  • the resin curable material for forming the nipple pack-coated resin container is a polymer organic solvent solution in addition to a water-based emulsion using a polymer compound as a dispersoid and water as a dispersion medium. May be.
  • a polymer compound dissolved in the organic solvent natural rubber, synthetic rubber, or synthetic resin as described in the above polymer latex can be used without limitation.
  • a solution obtained by dissolving polyurethane rubber as a solute in tetrahydrofuran as an organic solvent a solution obtained by dissolving a copolymer of vinyl acetate and another vinyl ester as a dispersoid in xylene as an organic solvent
  • a predetermined amount of the above-mentioned additive to the polymer latex and other various additives for plastics may be blended.
  • Nipple pack coated resin container using resin curable material forms nipple pack coated resin container on the surface of gelled nipple pack formed on livestock nipple A resin curable material is applied, cured, and formed into a film. As a result, a composite nipple pack for livestock in which the surface of the nipple pack is coated with the nipple pack-coated resin container is obtained (double coating method).
  • a resin curable material preferably a polymer
  • a latex or a polymer organic solvent solution may be applied and solidified to form. The following details of this method will be described by taking as an example the case where the resin curable material for forming the nipple pack-coated resin container is a polymer latex.
  • the resin curable material is a polymer organic solvent solution. In this case, it may be carried out according to this.
  • Examples of the method for applying the polymer latex to the surface of the nipple pack include a dipping method, a brush coating method, and a spraying method, but are not particularly limited.
  • the dipping method is preferred.
  • first put the polymer latex into a cylindrical or cup-shaped nipple pack immersion container that can fully accommodate the nipple pack with a margin and the nipple pack immersion container is attached to the nipple pack
  • the container is moved toward the tip of the nipple with the nipple pack attached (lowered). ).
  • the dipping may be performed such that the nipple length is 100% and 90% or more, preferably 95% or more of the nipple is immersed in the polymer latex on the basis of the length.
  • the viscosity of the polymer latex when using the above-described dipping method may be appropriately selected so as to facilitate dipping the nipple with the nipple pack in the polymer latex. Since it is difficult to sag and the operability is deteriorated, the value measured by a cone plate viscometer at 23 ° C. is preferably in the range of 50 to 1,500 dPa ⁇ s. On the other hand, the viscosity of the polymer latex mixture in the case of using the spraying method is preferably in the range of 50 to 400 dPa ⁇ s from the viewpoint of easy spraying.
  • the nipple pack immersion container is clean, its material is not limited and any metal, plastic, paper, etc. can be used. Further, the container only needs to have a minimum internal volume necessary for adhering the polymer latex to the teat in order to reduce waste of the polymer latex. In the case of a cylindrical or cup-shaped container, one having an inner diameter of about 4 cm to about 6 cm and a height of about 5 cm to about 10 cm can be used. It is convenient if a mark is provided inside the container so as to accommodate an appropriate amount of polymer latex. In order to ensure the fluidity of the polymer latex, the immersion is preferably started immediately after the preparation of the polymer latex.
  • the dipping time is within the initial curing time (preferably 20 to 130 seconds) in order to allow the polymer latex to sufficiently adhere to the nipple previously mounted with a nipple pack while the polymer latex has sufficient fluidity. It is preferable that In order to uniformly attach the polymer latex, the speed at which the container is moved in the direction of the nipple tip after dipping (pull-down speed) is preferably 10 to 100 mm / second, and preferably 20 to 50 mm / second. Is more preferable.
  • the nipple pack immersion container is immediately removed, and the polymer latex mixture is dried to evaporate water as a dispersion medium.
  • the next solidification mechanism that is, the polymer particles agglomerate and emulsifiers, inorganic salts, etc. are concentrated in the voids ⁇ the adsorption protective layer is destroyed and the exposed polymers start to fuse ⁇ polymer A film is formed through a mechanism in which interdiffusion of chains and diffusion of a water-soluble substance into the polymer proceed, and a composite teat pack is obtained.
  • the solidification mechanism is substantially different from the mechanism by which the polymer latex is solidified. Absent.
  • solidification in the case of a polymer latex is one in which water is evaporated and the polymer particles are fused irreversibly to form a film and cured, while in the case of a polymerized organic solvent solution In the solidification, the organic solvent is evaporated and the polymer particles are fused irreversibly to form a film and harden.
  • the nipple pack of the present invention is intended for livestock such as dairy cows, sheep and goats.
  • the organic solvent evaporation step it is preferable to prepare a working environment so that livestock and workers are not adversely affected by the organic solvent.
  • a working environment when working in a limited space such as a dairy barn, it is preferable to prepare a working environment.
  • MFT minimum film-forming temperature
  • the drying temperature of the polymer latex mixture must be determined taking into account the glass transition temperature Tg of the polymer.
  • the film formed can be cross-linked to greatly improve the thermal and mechanical properties, adhesion, and the like. It is common to copolymerize reactive monomers and crosslink using the reactive groups.
  • the composite nipple pack kit of the present invention is for completely adhering and covering livestock, particularly nipples of dairy cows, to protect the nipple, and for that purpose, high film-forming power, good adhesion to domestic nipples, Considering that it does not cause over-curing, has little deformation due to drying, can maintain various physical properties such as elasticity and moisture retention for at least 2 weeks, and must be easily peeled off after use.
  • NR, EBR, SBR, SB, NBR and CR latex are most preferable.
  • nipple pack-coated resin container to be used may be formed into a container shape by a known molding method using natural rubber, synthetic rubber or synthetic resin.
  • a molding method press molding, injection molding, extrusion molding, injection molding, cast molding, or the like may be performed as appropriate.
  • the rubber may be vulcanized using a solid rubber vulcanizing agent (crosslinking agent).
  • a polymer latex composed of an aqueous emulsion using natural rubber, synthetic rubber or synthetic resin as a dispersoid and water as a dispersion medium, or from an organic solvent solution in which natural rubber, synthetic rubber or synthetic resin is dissolved in an organic solvent, You may shape
  • natural latex, synthetic rubber or synthetic resin which is the main raw material used in the manufacturing method of the nipple pack-coated resin container, is used as a dispersoid, a polymer latex composed of an aqueous emulsion using water as a dispersion medium, or natural rubber, synthetic rubber
  • a dispersoid a polymer latex composed of an aqueous emulsion using water as a dispersion medium, or natural rubber, synthetic rubber
  • organic solvent solution in which rubber or synthetic resin is dissolved in an organic solvent, and the additives mentioned in the above section Resin curable material for forming a nipple pack-coated resin container. I can do so, so I will omit the explanation.
  • the nipple pack for livestock of the present invention can be used for protecting the nipple of livestock in the manner described above. Specifically, it can be used for protection from infectious mastitis, protection from environmental mastitis, protection from dirt and other external environmental factors.
  • the livestock is a livestock for milking, for example, dairy cows, goats, and other livestock for which milking is performed.
  • Alginate Alg-K Potassium alginate (viscosity of 1% aqueous solution at 20 ° C .: 600 mPa ⁇ sec)
  • ALG-Na Sodium alginate (viscosity of 1% aqueous solution at 20 ° C .: 120 mPa ⁇ sec)
  • B water distilled water
  • C gelling agent anhydrous gypsum: anhydrous calcium sulfate dihydrate
  • gypsum calcium sulfate dihydrate calcium chloride dihydrate
  • P1 liquid paraffin [viscosity at 20 ° C.
  • Fluid P2 Liquid paraffin [Viscosity at 20 ° C .: 300 mPa ⁇ sec, Solubility in water ⁇ 0.001 mg / L (almost insoluble), boiling point 590 ° C. at 1 atmosphere]
  • SO Silicone oil (polydimethylsiloxane) [Viscosity at 20 ° C .: 300 mPa ⁇ sec, Solubility in water ⁇ 0.001 mg / L (almost insoluble), boiling point 250 ° C.
  • DC decane [solubility in water (20 ° C.): 0.009 mg / L, boiling point 174 ° C. at 1 atm]
  • TDOH Tridecanol [Solubility in water (20 ° C.): 0.38 mg / L, boiling point 160 ° C.
  • the dimensions (width, length, thickness) of the sample piece were measured using a measuring microscope (Olympus "STM6"), and the initial volume (V1 / mm 3 ) of the sample piece was calculated.
  • wrap the sample piece with a cloth soaked with emulsion freshly squeezed raw milk
  • store it in a 25 ° C. incubator for 24 hours take out the sample piece, and visually evaluate the surface condition according to the following evaluation criteria did.
  • Hardened body surface visual evaluation criteria ⁇ : Wrinkles and cracks are not seen at all and are indistinguishable from the initial state. ⁇ : Wrinkles can be confirmed, which is different from the initial state. X: Innumerable wrinkles were confirmed, cracks were also confirmed, and clearly different from the initial state.
  • ⁇ The nipple pack maintains elasticity and can be easily deformed when pinched with fingers.
  • the pack is well bonded (adhered) to the pseudo nipple, and when peeled off, no water separation or the like occurs at the contact portion (inner side) with the nipple.
  • delta The teat pack surface has become a little hard by drying. When it is pinched with a finger to be deformed, a considerable force is required, but the cured body does not break.
  • the pack is well adhered (adhered) to the pseudo nipple, and when peeled off, no water separation or the like occurs at the contact portion (inner side) with the nipple.
  • X The nipple pack is very hard due to drying. Even if it is pinched strongly with a finger, it cannot be deformed at all, and if further force is applied, the cured body will break. Due to the contraction, the pack is peeled off from the pseudo-nipple and easily detached from the pseudo-nipple. When removed, water separation is seen at the contact portion (inside) with the nipple.
  • Example 1 (A) 10 g of Alg-K as an alginate and (C) 40 g of anhydrous gypsum as a gelling agent were weighed and mixed in advance until a uniform powder was obtained to obtain a powder material. Next, 150 g of distilled water as (B) water and 20 g of fluid P as (D) poorly water-soluble solvent were weighed and stirred in advance until a uniform liquid was obtained to obtain a liquid material. The total amount of the obtained powder material and liquid material was put in a kneading cup, and kneaded so that air bubbles would not be mixed until it became a uniform paste using a spatula, to prepare a nipple pack kneaded product. Using the obtained nipple pack kneaded product, the evaluation of the effect of the emulsion and the evaluation of the effect when left for a long period of time were performed.
  • Examples 2 to 30 A nipple pack kneaded product was prepared in the same manner as in Example 1 except that the composition of the nipple pack kneaded product was changed to the contents shown in Tables 1 and 2. Was used to evaluate the effect of the emulsion and the effect of long-term standing.
  • Example 31 (A) 100 g of Alg-K as an alginate and (B) 1,500 g of distilled water as water are weighed and kneaded for 1 hour using a small kneader (Aiko mixer manufactured by Aiko Sangyo Co., Ltd.). Prepared. (C) 400 g of anhydrous gypsum as a gelling reagent and (D) 200 g of liquid paraffin P1 as a slightly water-soluble solvent were weighed and kneaded for 1 hour using the same small kneader to prepare a hardener paste.
  • the nipple pack kneaded product was prepared. Using the obtained nipple pack kneaded product, the effect evaluation of the emulsion and the effect evaluation during long-term standing were performed.
  • Examples 32 to 39 The composition of the nipple pack composition was adjusted to the contents shown in Table 3, and the nipple pack kneaded product was prepared in the same manner as in Example 31. Evaluation and evaluation of effects during long-term standing were performed.
  • Tables 5 to 7 show the results of the evaluation of the effects of the emulsions of the samples of Examples 1 to 39 and Comparative Examples 1 to 8, and the evaluation of the effects when left standing for a long time, respectively.
  • Examples 1 to 39 were adjusted so as to satisfy all the requirements of the present invention, but in any case, the shrinkage of the cured product when contacted with the emulsion was small, and good results were obtained. It was obtained, and after the pseudo nipple was packed, the cured body was not dried for 2 days or more, and peeling from the pseudo nipple was not confirmed.
  • Examples 11 to 30 and Examples 36 to 39 are examples in which (E) non-reducing sugar is blended with the nipple pack kneaded product. It can be seen that the water retention capacity of the kneaded product has been greatly improved.
  • Comparative Example 1 is a case where the (D) poorly water-soluble solvent of the present invention was not used, but a hydrophobic film was not formed on the surface of the cured product of the nipple pack kneaded product, and therefore contacted with the emulsion
  • the alginate in the teat pack on the contact surface is excessively cured, and not only the surface of the cured body is roughened, but also the shrinkage rate of the cured body is greatly increased.
  • the nipple pack shrinks due to drying and peels off from the nipple.
  • the comparative example 2 is a case where a water-soluble solvent is blended instead of using the (D) poorly water-soluble solvent of the present invention, a hydrophobic film is similarly formed on the surface of the cured product of the nipple pack kneaded product Since it is not formed, not only is the surface of the cured body roughened, but the shrinkage of the cured body is greatly increased.
  • Comparative Example 3 is a case where (D) a non-reducing sugar is blended without blending the (D) poorly water-soluble solvent of the present invention, but due to the non-reducing sugar blending effect, the water retention is improved slightly. Although the improvement is seen, only insufficient results have been obtained to supplement the blending effect of the poorly water-soluble solvent.
  • Comparative Examples 4 to 6 are cases where, instead of using the (D) poorly water-soluble solvent of the present invention, a water-soluble solvent was blended, and (E) a non-reducing sugar was blended.
  • a water-soluble solvent was blended, and (E) a non-reducing sugar was blended.
  • Comparative Example 7 is a case where (B) water of the present invention was not blended, but since the alginate and calcium ions cannot react, the teat pack does not harden.
  • Comparative Example 8 is a case where the (C) gelling reagent of the present invention was not blended, but cannot be used because the teat pack does not harden.
  • Alginate Potassium alginate (viscosity at 20 ° C., 1% aqueous solution 600 mPa ⁇ sec)
  • Alg-Na Sodium alginate (20 ° C., 1% aqueous solution viscosity 120 mPa ⁇ sec) 2.
  • Slightly water-soluble solvent [fluid P]: liquid paraffin (20 ° C. viscosity 150 mPa ⁇ sec, solubility in water ⁇ 0.001 mg / L, almost insoluble; boiling point 450 ° C. at 1 atm) 3. 3.
  • Nipple pack elasticity evaluation method (elastic strain measurement method) 1-1: Method for Measuring Initial Elastic Strain A paste obtained by weighing a water blend of each nipple pack composition for domestic animals into a kneading cup and kneading with a spatula so that no bubbles are mixed, A plastic ring A (inner diameter: 31 mm, outer diameter: 38 mm, height: 16 mm) was placed on the upper surface (length 45 mm ⁇ width 45 mm), and then filled in the plastic ring A. At this time, time measurement was started by the first stopwatch.
  • a plastic ring B (inner diameter: 13 mm, outer diameter: 25 mm, height: 20 mm) was further inserted into the plastic ring A filled with the paste, thereby filling the plastic ring B with the paste.
  • the plastic ring B and the two acrylic plates disposed at both ends of the plastic ring B were fixed with a small vise.
  • both ends are pressed and fixed with an acrylic plate by a vise and the plastic ring B filled with the kneaded material is put in a water tank maintained at 35 ° C. 3 minutes after being put in (3 minutes and 30 seconds after the start of time measurement). Thereby, a cylindrical gelled product sample was obtained in the plastic ring B.
  • this columnar gel product sample is set in a compression tester (made by Nippon Mec Co., Ltd., impression material elasticity comparison tester “A-002”) so that a load is applied from the central axis direction.
  • a compression test was performed according to the following procedure after 4 minutes had elapsed from the start of the time measurement of one stopwatch. First, at the same time as applying a load of 100 gf / cm 2 to the gelled material sample, the time measurement is started by the second stopwatch, and the dial gauge after the measurement time of the second stopwatch has passed 30 seconds. The value A (mm) was read.
  • elastic strain ( ⁇ e) was determined based on the measured values A and B and the following formula. And the average value of each elastic strain obtained by implementing the same evaluation 3 times about the same teat pack was made into the elastic strain (initial stage) of hardened
  • Elastic strain ( ⁇ e) (AB) / 20 ⁇ 100 (%) 1-2: Measurement method of elastic strain after 14 days
  • a cylindrical gelled sample of a domestic nipple pack composition was obtained by the same method as the method for measuring initial elastic strain.
  • the entire gelled material sample is immediately hidden in a 50 ml glass container filled with 40 ml of the resin curable material.
  • the resin is pulled out and left for 10 seconds to allow the excess resin curable material to drip.
  • compressed air is blown lightly for 30 seconds to volatilize the volatile components. It was confirmed that it was covered with a solidified layer.
  • the gel sample prepared as described above was stored in a 25 ° C. incubator for 14 days.
  • the test pseudo coated with the nipple pack was immediately placed in a 50 ml glass container filled with 40 ml of the resin curable material. After the nipple is inserted until the entire surface is hidden, it is pulled out and allowed to stand for 10 seconds. After the excess of the resin curable material has dropped, the volatile components are volatilized by lightly blowing compressed air for 30 seconds. It was confirmed that it was covered with a solidified layer of a curable material. Seven similar test pieces were prepared, and all the test pieces were stored in a 25 ° C. incubator.
  • test pieces Each time a desired number of days elapses, one of the test pieces was taken out and peeled off from the simulated nipple, and the interior nipple pack was evaluated for dryness and adhesion with the simulated nipple according to the following evaluation criteria.
  • Example 40 12 g of urethane rubber and 88 g of tetrahydrofuran were weighed and stirred until a uniform solution was obtained, thereby preparing a resin curable material for manufacturing a teat pack-coated resin container shown in “a” of Table 8. Next, weigh (A) 10 g of Alg-K as the alginate, (C) 40 g of anhydrous gypsum as the gelling reagent, and (E) 60 g of trehalose as the non-reducing sugar until a uniform powder is obtained. It mixed beforehand and the powder material was obtained. Next, 150 g of distilled water as (B) water and 20 g of fluid P as (D) poorly water-soluble solvent were weighed to obtain a liquid material.
  • nipple pack composition for livestock.
  • nipple pack elasticity evaluation elastic strain
  • peelability evaluation during long-term standing were performed.
  • Examples 41 to 62 The composite nipple pack kit was prepared in the same manner as in Example 40 except that the resin curable material and the composition of the domestic nipple pack composition were changed to the contents shown in Table 13, respectively. Using this, the nipple pack elasticity evaluation (elastic strain) and the peelability evaluation after standing for a long time were performed. [Examples 63 to 70] A nipple pack was obtained in a single-coating mode using only the domestic nipple pack composition having the composition shown in Table 13 without using a resin curable material in combination, and nipple pack elasticity evaluation (elastic strain), and The peelability was evaluated after standing for a long time.
  • Example 71 12 g of urethane rubber and 88 g of tetrahydrofuran were weighed and stirred until a uniform solution was obtained, thereby preparing a resin curable material for manufacturing a teat pack-coated resin container shown in “a” of Table 8.
  • A 100 g of Alg-K as the alginate
  • B 1,500 g of distilled water as the water
  • E 600 g of trehalose as the non-reducing sugar
  • 295 g of diatomaceous earth 295 g of diatomaceous earth as the other components are weighed in small kneading.
  • a base paste was prepared by kneading for 1 hour using a container (Aiko mixer manufactured by Aiko Sangyo Co., Ltd.).
  • the gelling material for the nipple pack was prepared.
  • nipple pack elasticity evaluation elastic strain
  • peelability evaluation during long-term standing were performed.
  • Example 72 to 73 The composite nipple pack kit was prepared in the same manner as in Example 71 except that the resin curable material and the composition of the domestic nipple pack composition were changed to the contents shown in Table 13, respectively.
  • the nipple pack was evaluated for elasticity (elastic strain) and peelability when left for a long period of time.
  • a composite nipple pack kit was prepared in the same manner as in Example 40 except that the composition of the resin curable material and the domestic nipple pack composition was changed to the contents shown in Table 14, and the resulting composite nipple pack was used.
  • the nipple pack elasticity was evaluated (elastic strain), and the peelability was evaluated when left for a long time.
  • Tables 8 and 9 show the compositions of the resin curable materials for producing nipple pack-coated resin containers used in Examples 40 to 73 and Comparative Examples 9 to 18, and Tables 10 show the compositions of the nipple pack compositions for livestock.
  • Table 11 and Table 12 show.
  • Table 13 and Table 14 show the nipple pack elasticity evaluation (elastic strain) of the composite nipple packs of Examples 40 to 73 and Comparative Examples 9 to 18, and the peelability evaluation results when left for a long time, respectively. Show.
  • the number in the leftmost column is not the number of the example but the number indicating the composition.
  • Latex grade manufactured by Tosoh Corporation [Skyplane LA-502], registered trademark) * 5) Made by Hosoi Chemical Co., Ltd .; pure content ⁇ 99.9%; particle size ⁇ 550 * 6) Made by Honjo Chemical Co., Ltd. * 7) Sakai Chemical Industry Co., Ltd. * 8) Heat-resistant anti-aging agent and (D ozone deterioration preventing agent) * 9) Carboxylate * 10) For pH reduction * 11) Whiting * 12) Titanium white * 13) Liquid paraffin: Emulsified and blended into latex. * 14) Add so that the dispersion is 40%.
  • Example 74 The NR latex blends shown in Table 15 were placed in a storage / ripening tank and vulcanized under pre-curing conditions of 45 minutes to 75 ° C., 90 minutes at 75 ° C., and 40 minutes to 20 ° C. Next, it is aged in a storage / aging tank for 24 hours, and further aged for 21 days.
  • the NR latex compounded liquid that had been pre-vulcanized and ripened for 21 days was transferred to an extraction and purification tank (immersion tank) with a transfer pump.
  • the surface of the hard glass immersion mold which has been manufactured in advance in the same shape as the nipple with an average length of 80 mm of Holstein dairy cows, is highly washed.
  • the dipping-drying and dipping-drying cycles were repeated twice, followed by further drying and demolding to produce a nipple pack-coated resin container having a thickness of 0.5 mm.
  • the manufactured nipple pack-covered resin container was inspected by an electrical continuity test, a water leak test, and an air-filling burst test to confirm acceptance.
  • a nipple pack composition for livestock having the same composition as that used in Example 41 was described in Japanese Patent No. 4916440.
  • the nipple pack composition for livestock was gelled by being immersed and supported with a hand or a jig for 5 minutes, and fixed to the nipple pack-coated resin container.
  • an instrument such as a milking cup used in a milker may be diverted.
  • Example 74 Since the domestic nipple pack composition used in Example 74 is the same as that used in Example 41, its [elastic evaluation, elastic strain /%] is in accordance with the evaluation of Example 41 shown in Table 13. Carried out. Further, in accordance with the above-mentioned [Peelability evaluation method for long-term standing], Example 74 [Peelability evaluation for long-time standing] was performed and shown in Table 16.
  • Example 75 to 82 Comparative Example 19 The same steps as in Example 74 were repeated except that the polymer latex formulation, the thickness of the nipple pack-coated resin container, and the nipple pack composition for livestock were changed to the contents shown in Table 16, respectively. Obtained results.
  • Examples 74 to 82 are examples in which nipple pack-coated resin containers were employed. That is, a container made of a polymer latex and having a shape substantially the same as that of a dairy cow's teat is preliminarily prepared, and after the nipple pack composition for livestock is filled in the container, the teat is pressed, immersed, gelled, Is coated with a nipple pack composition for livestock, and the gel nipple pack is further coated with a nipple pack-coated resin container.
  • the advantage of this embodiment is that a nipple pack-coated resin container manufactured in advance in a separate process from the work site is used, so that the nipple pack composition for livestock is applied to the nipple in a narrow barn or a limited work site.
  • the load on workers and livestock is also small, and if a device such as a milking cup used for a milker is used, it can be semi-automated or automated It is a point.
  • Example of using specific M / G ratio alginate for livestock nipple pack composition >> Next, in Examples 83 to 137, when the specific M / G ratio alginate is used as the alginate of the nipple pack composition for livestock, the improvement effect such as the mechanical strength of the obtained nipple pack is described as “Single “Examples by Coating Method” (Examples 83 to 126) and [Examples by Double Coating Method] (Examples 127 to 137) are clarified sequentially.
  • Examples 127 to 135 are cases in which the composite teat pack was manufactured by “ii) Double coating method using a resin curable material”.
  • And 137 are the cases of i) “double coating method using nipple pack-coated resin container”.
  • Non-reducing sugar Cdex ⁇ ⁇ -cyclodextrin
  • Cdex ⁇ ⁇ -cyclodextrin
  • P1 liquid paraffin (20 ° C. viscosity 150 mPa ⁇ sec, solubility in water ⁇ 0.001 mg / L hardly dissolves)
  • Gly glycerin PG: propylene glycol 4.
  • Surfactant Dec-3O Decaglyceryl trioleate Other MgO: Magnesium oxide FTiK: Potassium titanium fluoride
  • ZnO Zinc oxide
  • P3Na Trisodium phosphate MT-10: Amorphous silica with a particle size of 0.02 ⁇ m (treated with methyltrichlorosilane)
  • the first precipitate was re-dispersed in 300 ml of water, 0.1M aqueous sodium hydroxide solution was added to neutralize the pH once to 7.0, and then 0.025M HCl aqueous solution was added. The pH of the mixture was adjusted to 2.8 to 3.0 and stirred for 1 hour. Thereafter, the precipitate (hereinafter referred to as “second precipitate”) and the supernatant (hereinafter referred to as “second supernatant”) are separated and collected by centrifugation (3,000 rpm, 30 minutes). did.
  • the second supernatant was neutralized with 0.1 M aqueous sodium hydroxide so that the pH was 7.0, the liquid was evaporated, and the solid was recovered. And sugar amount X2 (mg) was quantified with respect to this solid content using the phenol sulfuric acid method.
  • the second precipitate was re-dispersed in 100 ml of water and neutralized with 0.1 M aqueous sodium hydroxide so that the pH was 7.0, and then the liquid was evaporated to recover the solid. And sugar amount X3 (mg) was quantified with respect to this solid content using the phenol sulfuric acid method.
  • M1 the existence ratio of MG random blocks
  • M2 the existence ratio of MM blocks
  • M3 the existence ratio of GG block
  • Nipple pack elasticity evaluation method (elastic strain measurement method) Examples of “1. Nipple pack elasticity evaluation method (elastic strain measurement method)” “1-1: Initial elasticity” in the above-mentioned example of “Example of producing a composite nipple pack for livestock by the double coating method and protecting the nipple” The initial elastic strain of the gelled material sample was measured in the same manner as in “Strain Measurement Method”. Further, in the same manner as in “1-2: Measurement method of elastic strain after 14 days”, the elastic strain after 14 days of the nipple pack (an embodiment in which the surface is not coated with a resin curable material for manufacturing a nipple pack-coated resin container) is measured. It was measured. In addition, in the above “1-2: Measurement method of elastic strain after 14 days”, the elastic strain after 7 days of the teat pack is also combined except that the gel sample is stored for 7 days in a 25 ° C. incubator. Measured.
  • the plastic ring B (inner diameter 13 mm, outer diameter 25 mm, height 20 mm) was further inserted into the plastic ring A filled with the kneaded material, thereby filling the plastic ring B with the kneaded material.
  • the plastic ring B and the two acrylic plates disposed at both ends of the plastic ring B were fixed with a small vise.
  • both ends of the plastic ring B are pressed and fixed by an acrylic plate with a vise, and the plastic ring B filled with the kneaded material is immersed in 35 ° C. water.
  • the gelled material sample was taken out from the mold 3 minutes 30 seconds after the start of kneading (initial) and after 7 days. Thereby, a cylindrical gelled sample gelled in the plastic ring B was obtained.
  • this columnar gelled sample was set on an autograph (AG-I) manufactured by Shimadzu Corporation so that a load was applied from the center axis direction, and 4 times from the start of the time measurement of the first stopwatch. After 30 minutes, the autograph was started at a crosshead speed of 5 mm / min, and the compressive strength of each gelled product was measured at the beginning and after 7 days.
  • AG-I autograph manufactured by Shimadzu Corporation
  • the pulled-out pseudo nipple is hung in a vertical state and left to stand (15 minutes) until the nipple pack material is cured, and then repeatedly set on the jig of a collision load tester (Tokyo Giken K655) to simulate the cow bed.
  • the evaluation was performed with the number of collisions at the time when the nipple pack was broken or dropped off on the acrylic plate at a speed of 60 times per minute with a stress of 1.5 Kgf.
  • Method of measuring viscosity of kneaded product Weigh a sample in a kneading cup and use a spatula to knead the paste so that no bubbles are mixed. put an appropriate amount to the meter CVO120HR), and starts measuring the viscosity while maintaining at 23 ° C., shear rate 0.1 rpm / viscosity after 100 seconds kneading start at sec ⁇ 23 0.1 / dPa ⁇ s (Deshipasukaru Sec).
  • the measurement conditions for the viscosity were a cone diameter of 2 cm and a cone inclination angle of 1 °.
  • nipple pack composition for livestock is weighed into a kneading cup, and a paste obtained by kneading using a spatula so that no bubbles are mixed, has an inner diameter of 6 cm ⁇ and a length of 8 cm. Filled into a cylindrical container.
  • a soft rubber pseudo nipple shaped like the nipple of a cow (with an inner diameter of 3 cm ⁇ and a length of 4 cm) slowly apply force from the state where it is lightly in contact with the paste filled in a cylindrical container. Then, until all the teats were hidden, they were pulled out immediately.
  • Example 83 (A) 10 g of Alg-1 as an alginate, (B) 60 g of trehalose as a non-reducing sugar, (E) 40 g of anhydrous gypsum as a gelling reagent, and mixed in advance until a uniform powder is obtained. A powder material was obtained. Next, (D) 20 g of fluid P1 as a poorly water-soluble solvent and (C) 150 g of distilled water as water were weighed and stirred in advance until a uniform liquid was obtained to obtain a liquid material.
  • the whole amount of the obtained powder material and liquid material was put into a kneading cup, and kneaded so that air bubbles would not be mixed until it became a uniform paste using a spatula to prepare a water kneaded product of a domestic nipple pack composition. .
  • a water kneaded product of a domestic nipple pack composition for livestock, the initial evaluation of the gelled product, the elasticity evaluation after 7 days and 14 days, and the compressive strength, the simulated nipple repeated stress durability evaluation of the gelled product after 7 days, The kneaded product was subjected to viscosity measurement and applicability evaluation test.
  • Example 84 to 104 A paste was prepared in the same manner as in Example 83, except that the composition of the water-mixed nipple pack composition for livestock was changed to the contents shown in Table 20, respectively. , The elasticity evaluation and compressive strength after 7 days and 14 days after the gelled product, the pseudo-nipple repeated stress durability evaluation of the gelled material after 7 days, the viscosity measurement of the kneaded product, and the applicability evaluation test, respectively. went.
  • Example 105 (A) 100 g of Alg-1 as an alginate, (B) 600 g of trehalose as a non-reducing sugar, (C) 1500 g of distilled water as water and weighed using a small kneader (Aiko mixer manufactured by Aiko Sangyo Co., Ltd.). The substrate paste was adjusted by kneading for 1 hour. (E) 400 g of anhydrous gypsum as a gelling reagent and (D) 200 g of fluid P1 as a hardly water-soluble solvent were weighed and kneaded for 1 hour using the same small kneader to prepare a hardener paste.
  • Example 106 to 119 A paste was prepared in the same manner as in Example 105, except that the composition of the water-mixed nipple pack composition for livestock was changed to the contents shown in Table 20, and the resulting water-mixed nipple pack composition was used.
  • Example 120 to Example 126 A paste was prepared in the same manner as in Example 83, except that the composition of the water kneaded pack for livestock nipple pack composition was changed to the contents shown in Table 21, and each kneaded pack for nipple pack obtained was used, Elasticity evaluation and compressive strength of the gelled material at the beginning and after 7 days, pseudo-nipple repeated stress durability evaluation of the gelled material after 7 days, viscosity measurement of the kneaded material, and applicability evaluation test by the dipping method were performed.
  • Tables 17, 18 and 19 show the compositions of the water blends of the domestic nipple pack compositions in Examples 83 to 126, respectively. Further, in each of the examples 83 to 126, the initial measurement of the gelled product, the elasticity evaluation and compressive strength after 7 days and 14 days passed, each measurement of the pseudo-nipple repeated stress durability evaluation of the gelled product after 7 days, kneaded product Table 20 and Table 21 show the results of viscosity measurement and applicability evaluation test, respectively.
  • the resin curable material for forming the nipple pack-covered resin container had the following composition.
  • [Composition A] 12 parts by mass of solute polyurethane rubber dissolved in 88 parts by mass of solvent tetrahydrofuran.
  • [Composition B] [Natural Rubber N-60R] -Natural Rubber Latex (Rubbex Latex, registered trademark [N-60R]).
  • [Composition C] and [Composition D] Details are shown in Table 22. In Table 22, parts by mass are dry parts by mass.
  • the teat pack covering resin container used in the present embodiment is not a final product itself but a container for covering a gel pack. Therefore, a pre-vulcanization method that contributes to automation and contributes to cost reduction is adopted because a heating step by heating after product processing is not required.
  • the polymer latex blend shown in Table 22 is pre-blended with components necessary for pre-vulcanization.
  • the cylindrical hard glass immersion mold which is the same as the gelled product sample manufactured with the teat pack material in the “(b) Method for measuring elastic strain of gelled product”, is used as the central axis. While rotating in a vertically standing state, it was immersed to a depth that leaves only the upper end surface of the cylinder. Subsequently, the latex compounding liquid which coat
  • a nipple pack-coated resin container produced as described above is filled with a nipple pack kneaded product, gelled for 5 minutes, and the surface of the gelled product sample coated with the nipple-coated resin container.
  • the gelled sample inside after being stored in a 25 ° C. incubator for 7 days and 14 days by the same method as the measurement method of the elastic strain of the composite nipple pack in “1-1.”
  • the elastic strain ( ⁇ e) of each was determined.
  • Example 127 Combining the water blend of the domestic nipple pack composition of [Composition 1] in Example 83 with the resin curable material [Composition A], and combining by “ii) Double coating method using resin curable material” In an embodiment in which the nipple pack was manufactured, an evaluation test of elastic strain and compressive strength was conducted on the nipple pack inside after 7 days and 14 days.
  • Example 127 the composition of the water blend of the nipple pack composition for livestock and the composition of the resin curable material were changed to the contents shown in Table 17, respectively. Except that the composite nipple pack was manufactured by the “coating method”, the test was carried out in the same manner as in Example 127, and an evaluation test of the elastic strain and compressive strength of the gelled product in the composite nipple pack after 7 and 14 days was performed. .
  • Examples 136 to 137 By combining the water-mixed nipple pack composition for livestock of [Composition 1] in Example 83 and the resin curable material [Composition A], according to “i) Double coating method using nipple pack-coated resin container”. In an embodiment for producing a composite teat pack, an evaluation test of elastic strain and compressive strength was performed on the gelled product after 7 days and 14 days.
  • Table 23 shows the compositions of the water-mixed and resin-curable material of the domestic nipple pack composition used in the production of the composite nipple pack in Examples 127 to 137. Furthermore, Table 23 also shows the evaluation test results of the elastic strain and compressive strength of the gelled product inside the composite teat packs of Examples 127 to 137 after 7 days and 14 days.

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une partie de tétine de bétail ou analogue, ayant une force de formation de membrane élevée, une excellente élasticité, une grande adhérence à une surface de tétine, pas de séchage excessif, peu de déformation due au séchage, la capacité à être pelée facilement après utilisation, et une résistance mécanique suffisante pour supporter des impacts et analogues qui surviennent après l'installation de partie lorsqu'une vache laitière ou analogue s'allonge pour se reposer ou pendant un mouvement intense ; en particulier, une partie de tétine ou analogue dans laquelle un produit d'eau triturée forme un produit de gel ayant une excellente résistance mécanique, même lorsque le produit d'eau triturée a une teneur en eau élevée et une faible viscosité ayant une excellente couverture d'une tétine de bétail ; l'élasticité n'est pas facilement perdue en raison du séchage ; et la résistance mécanique élevée est bien conservée. Une composition de partie de tétine de bétail contenant un polysaccharide polyélectrolyte, un agent de réaction gélifiant et un solvant faiblement soluble dans l'eau comme composants principaux ; un récipient en résine de revêtement de partie de tétine pour recouvrir la composition de partie de tétine de bétail et un produit de gel de la composition de partie de tétine de bétail, ou un coffret de partie de tétine composite de bétail comprenant un matériau durcissant en résine pour former le récipient en résine de revêtement de partie de tétine ; ou, soit la composition de partie de tétine de bétail soit le coffret de partie de tétine composite de bétail ; un alginate étant choisi comme polysaccharide polyélectrolyte ; le rapport M/G, qui est le rapport molaire d'acide mannuronique β-D à l'acide guluronique α-L constituant l'alginate, est choisi pour être dans une plage allant de 0,4 à 0,7 ; et du tréhalose est de préférence ajouté comme sucre non-réducteur.
PCT/JP2014/052924 2013-02-07 2014-02-07 Composition de partie de tétine de bétail, partie de tétine de bétail, coffret de partie de tétine composite de bétail et procédé pour protéger une tétine de bétail WO2014123225A1 (fr)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
JP2013-021937 2013-02-07
JP2013021937 2013-02-07
JP2013-046475 2013-03-08
JP2013046475 2013-03-08
JP2013049491A JP2014168451A (ja) 2013-02-07 2013-03-12 家畜用乳頭パック及びそれを形成するための組成物、並びに家畜の乳頭を保護する方法
JP2013-049491 2013-03-12
JP2013057117 2013-03-19
JP2013-057117 2013-03-19
JP2013-182734 2013-09-04
JP2013182734A JP2014195448A (ja) 2013-03-08 2013-09-04 家畜用複合乳頭パックキット、及びこれを用いた家畜の乳頭を保護する方法
JP2013214852 2013-10-15
JP2013-214852 2013-10-15
JP2013264041A JP2015097522A (ja) 2013-03-19 2013-12-20 家畜用乳頭パック材、および家畜用複合乳頭パックキット
JP2013-264041 2013-12-20

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104257684A (zh) * 2014-09-17 2015-01-07 黑龙江省兽医科学研究所 奶牛乳头药浴涂膜剂及其制备方法
JP2016101159A (ja) * 2014-11-17 2016-06-02 株式会社トクヤマ 家畜用乳頭パック材料
CN110559313A (zh) * 2019-09-23 2019-12-13 天津农学院 一种海藻酸钠成膜基质奶牛乳头药浴液及其制备方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
JPH09500098A (ja) * 1993-04-15 1997-01-07 エコラブ インコーポレイテッド イオンバリア乳頭浸液
JP2006050911A (ja) * 2004-08-10 2006-02-23 National Agriculture & Bio-Oriented Research Organization 乳頭パック、乳頭保護方法および乳頭パックの塗布方法。

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09500098A (ja) * 1993-04-15 1997-01-07 エコラブ インコーポレイテッド イオンバリア乳頭浸液
JP2006050911A (ja) * 2004-08-10 2006-02-23 National Agriculture & Bio-Oriented Research Organization 乳頭パック、乳頭保護方法および乳頭パックの塗布方法。

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104257684A (zh) * 2014-09-17 2015-01-07 黑龙江省兽医科学研究所 奶牛乳头药浴涂膜剂及其制备方法
JP2016101159A (ja) * 2014-11-17 2016-06-02 株式会社トクヤマ 家畜用乳頭パック材料
CN110559313A (zh) * 2019-09-23 2019-12-13 天津农学院 一种海藻酸钠成膜基质奶牛乳头药浴液及其制备方法

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