WO2014077130A1 - 3-ヒドロキシテトラヒドロフランの製造方法、1,3-ブタンジオールの製造方法 - Google Patents
3-ヒドロキシテトラヒドロフランの製造方法、1,3-ブタンジオールの製造方法 Download PDFInfo
- Publication number
- WO2014077130A1 WO2014077130A1 PCT/JP2013/079406 JP2013079406W WO2014077130A1 WO 2014077130 A1 WO2014077130 A1 WO 2014077130A1 JP 2013079406 W JP2013079406 W JP 2013079406W WO 2014077130 A1 WO2014077130 A1 WO 2014077130A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reaction
- catalyst
- hydroxytetrahydrofuran
- hydrogen
- producing
- Prior art date
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- XDPCNPCKDGQBAN-UHFFFAOYSA-N 3-hydroxytetrahydrofuran Chemical compound OC1CCOC1 XDPCNPCKDGQBAN-UHFFFAOYSA-N 0.000 title claims abstract description 179
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 title claims abstract description 138
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 131
- 235000019437 butane-1,3-diol Nutrition 0.000 title abstract description 61
- 238000006243 chemical reaction Methods 0.000 claims abstract description 198
- 239000003054 catalyst Substances 0.000 claims abstract description 194
- 239000001257 hydrogen Substances 0.000 claims abstract description 157
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 157
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 147
- SSYDTHANSGMJTP-ZXZARUISSA-N (3s,4r)-oxolane-3,4-diol Chemical compound O[C@H]1COC[C@H]1O SSYDTHANSGMJTP-ZXZARUISSA-N 0.000 claims abstract description 104
- 229910021476 group 6 element Inorganic materials 0.000 claims abstract description 32
- 229910021474 group 7 element Inorganic materials 0.000 claims abstract description 32
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 94
- 229910052751 metal Inorganic materials 0.000 claims description 88
- 239000002184 metal Substances 0.000 claims description 88
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- 238000000034 method Methods 0.000 claims description 62
- 229910052809 inorganic oxide Inorganic materials 0.000 claims description 50
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 45
- 229910052741 iridium Inorganic materials 0.000 claims description 45
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 45
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 45
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- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 36
- 230000008569 process Effects 0.000 claims description 32
- 239000007809 chemical reaction catalyst Substances 0.000 claims description 29
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- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 24
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- 239000000377 silicon dioxide Substances 0.000 claims description 20
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- 150000001875 compounds Chemical class 0.000 abstract description 16
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- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 1
- 229940077239 chlorous acid Drugs 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- QGUAJWGNOXCYJF-UHFFFAOYSA-N cobalt dinitrate hexahydrate Chemical compound O.O.O.O.O.O.[Co+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O QGUAJWGNOXCYJF-UHFFFAOYSA-N 0.000 description 1
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002503 iridium Chemical class 0.000 description 1
- MVFCKEFYUDZOCX-UHFFFAOYSA-N iron(2+);dinitrate Chemical compound [Fe+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O MVFCKEFYUDZOCX-UHFFFAOYSA-N 0.000 description 1
- SZQUEWJRBJDHSM-UHFFFAOYSA-N iron(3+);trinitrate;nonahydrate Chemical compound O.O.O.O.O.O.O.O.O.[Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O SZQUEWJRBJDHSM-UHFFFAOYSA-N 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 229910052914 metal silicate Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 1
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- AOPCKOPZYFFEDA-UHFFFAOYSA-N nickel(2+);dinitrate;hexahydrate Chemical compound O.O.O.O.O.O.[Ni+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O AOPCKOPZYFFEDA-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
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- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- PUDIUYLPXJFUGB-UHFFFAOYSA-N praseodymium atom Chemical compound [Pr] PUDIUYLPXJFUGB-UHFFFAOYSA-N 0.000 description 1
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- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
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Images
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Definitions
- the present invention relates to a method for producing 3-hydroxytetrahydrofuran using 1,4-anhydroerythritol as a raw material.
- the present invention also relates to a method for producing 1,3-propanediol using 3-hydroxytetrahydrofuran as a raw material.
- glycerol produced as a by-product in producing the biodiesel fuel is a compound composed of three carbon atoms (C3 compound; for example, propylene, 1,2-propanediol, 1,3-propanediol, etc. ) Has also been studied as a basic chemical raw material for producing (see, for example, Non-Patent Document 1).
- C4 compound a technology for producing a compound composed of four carbon atoms (C4 compound) from biomass is also being studied, but has not yet been put into practical use.
- C4 compounds in particular, 1,3-butanediol is formulated as a moisturizing agent for cosmetics, detergents, shampoos, etc., and is also expected to be used as a raw material for pharmaceuticals, food additives, various solvents, etc. Has been. For this reason, development of a technique for producing 1,3-butanediol using biomass as a starting material is strongly demanded.
- the present inventors focused on 3-hydroxytetrahydrofuran, which is also a compound having 4 carbon atoms, as a raw material for 1,3-butanediol, and reacting 3-hydroxytetrahydrofuran with hydrogen to produce 1,3-butanediol. It has been found that there is a possibility of producing diols. However, at present, the production technology of 3-hydroxytetrahydrofuran using biomass as a starting material is not yet known.
- an object of the present invention is to provide a method for producing 3-hydroxytetrahydrofuran that can be used as a raw material for 1,3-butanediol using a compound derivable from biomass as a raw material.
- Another object of the present invention is to provide a method for producing 1,3-butanediol using 3-hydroxytetrahydrofuran as a raw material.
- 1,4-anhydroerythritol which can be easily derived from biomass erythritol, as a raw material, and reacted it with hydrogen to achieve high selectivity. It has been found that 3-hydroxytetrahydrofuran can be produced. The present inventors have also found that 1,3-butanediol can be produced with high selectivity by reacting 3-hydroxytetrahydrofuran as a raw material with hydrogen. The present invention has been completed based on these findings.
- the present invention provides a method for producing 3-hydroxytetrahydrofuran, comprising a step of producing 3-hydroxytetrahydrofuran by a reaction of 1,4-anhydroerythritol and hydrogen.
- reaction between 1,4-anhydroerythritol and hydrogen in the above step was selected from the group consisting of a carrier, an oxide of a Group 6 element and an oxide of a Group 7 element supported on the carrier.
- the method for producing 3-hydroxytetrahydrofuran proceeds in the presence of a catalyst containing at least one oxide.
- the present invention provides a method for producing the 3-hydroxytetrahydrofuran, wherein the carrier is activated carbon or an inorganic oxide.
- the present invention provides the method for producing 3-hydroxytetrahydrofuran, wherein the catalyst further contains a metal other than the Group 6 element and the Group 7 element supported on the carrier.
- the present invention provides the method for producing 3-hydroxytetrahydrofuran, wherein the metal is at least one metal selected from the group consisting of palladium, platinum, iron, cobalt, nickel, and copper.
- the present invention provides the method for producing 3-hydroxytetrahydrofuran, wherein the inorganic oxide is at least one inorganic oxide selected from the group consisting of titania, zirconia, magnesia, silica, and alumina.
- the present invention also relates to a catalyst for hydrogenation reaction of 1,4-anhydroerythritol used in a reaction for producing 3-hydroxytetrahydrofuran by reaction of 1,4-anhydroerythritol and hydrogen, comprising a carrier, There is provided a hydrogenation reaction catalyst comprising at least one oxide selected from the group consisting of Group 6 element oxides and Group 7 element oxides supported on the carrier.
- the hydrogenation reaction catalyst is provided, wherein the carrier is activated carbon or an inorganic oxide.
- the above-mentioned hydrogenation reaction catalyst containing a metal other than the Group 6 element and the Group 7 element supported on the carrier is provided.
- the hydrogenation reaction catalyst is provided, wherein the metal is at least one metal selected from the group consisting of palladium, platinum, iron, cobalt, nickel, and copper.
- the hydrogenation reaction catalyst is provided wherein the inorganic oxide is at least one inorganic oxide selected from the group consisting of titania, zirconia, magnesia, silica, and alumina.
- the present invention also provides a method for producing 1,3-butanediol, which comprises a step of producing 1,3-butanediol by reaction of 3-hydroxytetrahydrofuran with hydrogen.
- reaction of 3-hydroxytetrahydrofuran with hydrogen in the above step is a catalyst containing a support and at least one metal selected from the group consisting of iridium, rhenium, ruthenium, molybdenum, and tungsten supported on the support.
- metal selected from the group consisting of iridium, rhenium, ruthenium, molybdenum, and tungsten supported on the support.
- the present invention provides a method for producing the 1,3-butanediol, wherein the carrier is an inorganic oxide.
- the present invention provides the method for producing 1,3-butanediol, wherein the inorganic oxide is at least one inorganic oxide selected from the group consisting of silica, magnesia, titania, and alumina.
- the present invention provides the method for producing 1,3-butanediol, wherein the 3-hydroxytetrahydrofuran is 3-hydroxytetrahydrofuran produced by the reaction of 1,4-anhydroerythritol and hydrogen.
- the method for producing 1,3-butanediol as described above further comprises a step of producing 3-hydroxytetrahydrofuran by reaction of 1,4-anhydroerythritol and hydrogen before the step.
- the present invention also relates to a catalyst for hydrogenation reaction of 3-hydroxytetrahydrofuran used in a reaction for producing 1,3-butanediol by reaction of 3-hydroxytetrahydrofuran with hydrogen.
- a hydrogenation reaction catalyst comprising at least one metal selected from the group consisting of iridium, rhenium, ruthenium, molybdenum, and tungsten.
- the hydrogenation reaction catalyst is provided in which the carrier is an inorganic oxide.
- the hydrogenation reaction catalyst is provided, wherein the inorganic oxide is at least one inorganic oxide selected from the group consisting of silica, magnesia, titania, and alumina.
- a process for producing 3-hydroxytetrahydrofuran comprising a step of producing 3-hydroxytetrahydrofuran by reaction of 1,4-anhydroerythritol with hydrogen.
- the reaction between 1,4-anhydroerythritol and hydrogen in the above step is selected from the group consisting of a carrier and an oxide of a Group 6 element and an oxide of a Group 7 element supported on the carrier.
- the method for producing 3-hydroxytetrahydrofuran according to (1) which proceeds in the presence of a catalyst containing at least one oxide.
- (10) A ratio (molar ratio, metal conversion) of the Group 6 element and Group 7 element constituting the oxide in the catalyst and the metal [the metal / Group 6 element and Group 7 element]
- (11) The inorganic oxide according to any one of (4) to (10), wherein the inorganic oxide is at least one inorganic oxide selected from the group consisting of titania, zirconia, magnesia, silica, and alumina. -Process for the production of hydroxytetrahydrofuran.
- the molar ratio of hydrogen to 1,4-anhydroerythritol [hydrogen (mol) / 1,4-anhydroerythritol (mol)] to be subjected to the above reaction is 1 to 100 (1) to (14) The method for producing 3-hydroxytetrahydrofuran according to any one of the above. (16) The process for producing 3-hydroxytetrahydrofuran according to any one of (1) to (15), wherein the reaction temperature of 1,4-anhydroerythritol and hydrogen in the reaction is 50 to 250 ° C.
- a catalyst for hydrogenation reaction of 1,4-anhydroerythritol used in a reaction for producing 3-hydroxytetrahydrofuran by reaction of 1,4-anhydroerythritol and hydrogen comprising: a support; and A catalyst for hydrogenation reaction, comprising at least one oxide selected from the group consisting of a supported Group 6 element oxide and Group 7 element oxide.
- the amount of the oxide supported on the carrier (in terms of metal atoms constituting the oxide) is 0.01 to 50% by weight with respect to the total amount of the oxide and the carrier (100% by weight).
- a ratio (molar ratio, metal conversion) of the Group 6 element and Group 7 element constituting the oxide to the metal (the metal / Group 6 element and Group 7 element) is 50 /
- a method for producing 1,3-butanediol comprising a step of producing 1,3-butanediol by reaction of 3-hydroxytetrahydrofuran with hydrogen.
- the reaction between 3-hydroxytetrahydrofuran and hydrogen in the above step includes a support and at least one metal selected from the group consisting of iridium, rhenium, ruthenium, molybdenum, and tungsten supported on the support.
- the method for producing 1,3-butanediol according to (30) which proceeds in the presence of a catalyst.
- the supported amount (total amount) (in terms of metal atom) of at least one metal selected from the group consisting of iridium, rhenium, ruthenium, molybdenum and tungsten on the support is the total amount of the metal and the support.
- the ratio of iridium and rhenium in the catalyst (molar ratio, metal conversion) [Iridium / Rhenium] is 50/1 to 1/6, (1) according to any one of (31) to (37) A method for producing 3-butanediol.
- the molar ratio [hydrogen (mol) / 3-hydroxytetrahydrofuran (mol)] of hydrogen and 3-hydroxytetrahydrofuran to be subjected to the reaction is 1 to 100, according to any one of (30) to (40) Of 1,3-butanediol.
- a catalyst for hydrogenation reaction of 3-hydroxytetrahydrofuran used in a reaction for producing 1,3-butanediol by reaction of 3-hydroxytetrahydrofuran with hydrogen comprising a carrier and iridium supported on the carrier And a catalyst for hydrogenation reaction comprising at least one metal selected from the group consisting of rhenium, ruthenium, molybdenum, and tungsten.
- At least one metal selected from the group consisting of iridium, rhenium, ruthenium, molybdenum and tungsten supported on the carrier (total amount) (in terms of metal atoms) is the total amount of the metal and the carrier (100% by weight)
- the method for producing 3-hydroxytetrahydrofuran of the present invention is a method for producing 3-hydroxytetrahydrofuran from 1,4-anhydroerythritol, which can be easily derived from erythritol, which is a biomass. It greatly contributes to the creation of a sustainable society. Further, according to the above production method, 3-hydroxytetrahydrofuran can be produced with high selectivity, which is advantageous in terms of cost.
- the method for producing 1,3-butanediol according to the present invention is a method for producing 1,3-butanediol using 3-hydroxytetrahydrofuran, which can be derived from erythritol, which is biomass, as a starting material. Is a small contribution to the creation of a sustainable society. Further, according to the above production method, 1,3-butanediol can be produced with high selectivity, which is advantageous in terms of cost.
- FIG. 1 shows an example of the hydrogenation reaction step A in the method for producing 3-hydroxytetrahydrofuran of the present invention or the hydrogenation in the method for producing 1,3-butanediol of the present invention when a trickle bed reactor is used. It is a flowchart which shows an example of the reaction process B.
- a step of producing 3-hydroxytetrahydrofuran by reaction of 1,4-anhydroerythritol and hydrogen (sometimes referred to as “hydrogenation reaction step A”) is essential. It is characterized by including as a process of.
- 1,4-Anhydroerythritol 1,4-Anhydroerythritol (3,4-dihydroxyoxolane) used as a raw material in the hydrogenation reaction step A is a compound represented by the following formula (1).
- 1,4-Anhydroerythritol is a compound having a structure formed by dehydration condensation of the 1- and 4-position hydroxyl groups of erythritol, as shown in Formula (1).
- the 1,4-anhydroerythritol may be, for example, 1,4-anhydroerythritol produced by chemical synthesis, or 1,4-anhydroerythritol derived from a sugar such as glucose by a fermentation technique.
- 1,4-anhydroerythritol induced by the fermentation technique include 1,4-anhydroerythritol, which is produced by intramolecular dehydration of erythritol using erythritol derived from a sugar such as glucose as a raw material. 4-anhydroerythritol etc. are mentioned.
- the intramolecular dehydration reaction can be carried out by a known or conventional method, and is not particularly limited.
- the intramolecular dehydration reaction can be carried out according to the method of the dehydration reaction step described later.
- 1,4-anhydroerythritol 1,4-anhydroerythritol (unreacted 1,4-anhydroerythritol) recovered from the reaction mixture obtained in the hydrogenation reaction step A is reused. You can also
- the hydrogen (hydrogen gas) used in the hydrogenation reaction step A can be used in a substantially hydrogen-only state, or used in a state diluted with an inert gas such as nitrogen, argon or helium. You can also In addition, hydrogen recovered from the reaction mixture obtained as a result of the hydrogenation reaction step A (unreacted hydrogen) can be reused.
- the reaction of 1,4-anhydroerythritol and hydrogen in the hydrogenation reaction step A is performed using a catalyst (a reaction for producing 3-hydroxytetrahydrofuran by reaction of 1,4-anhydroerythritol and hydrogen, It is preferable to proceed in the presence of 4-anhydroerythritol hydrogenation catalyst.
- a catalyst By using a catalyst, the above reaction is promoted, the conversion of 1,4-anhydroerythritol is improved, and the selectivity of 3-hydroxytetrahydrofuran tends to be improved.
- the catalyst is at least selected from the group consisting of a carrier, an oxide of a Group 6 element and an oxide of a Group 7 element supported on the carrier, particularly in terms of the yield of 3-hydroxytetrahydrofuran.
- a catalyst containing a kind of oxide (sometimes referred to simply as “oxide”) (sometimes referred to as “catalyst (1) of the present invention”) is preferred.
- the Group 6 element include chromium (Cr), molybdenum (Mo), tungsten (W), and praseodymium (Pr).
- Examples of the Group 7 element include manganese (Mn), technetium (Tc), rhenium (Re), neodymium (Nd), and the like.
- tungsten is preferable as the metal constituting the oxide (metal oxide) supported on the carrier in the catalyst (1) of the present invention.
- a known or conventional carrier used in the catalyst can be used, and is not particularly limited.
- inorganic carriers such as inorganic oxides and activated carbon, ion exchange resins and the like
- organic substance carriers such as organic substance carriers.
- activated carbon and inorganic oxide are preferable from the viewpoint of reaction activity.
- activated carbon known or commonly used activated carbon can be used, and is not particularly limited. Activated carbon obtained from any raw material such as plant-based, mineral-based, or resin-based can also be used. Examples of the activated carbon include trade name “Vulcan XC72” (manufactured by CABOT), trade name “BP2000” (manufactured by CABOT), trade name “Shirasagi FAC-10” (manufactured by Nippon Enviro Chemicals), trade name Commercially available products such as “Shirasagi M” (manufactured by Nippon Enviro Chemicals Co., Ltd.), product name “Shirasagi C” (manufactured by Nippon Enviro Chemicals Co., Ltd.), and product name “Carboraffin” (manufactured by Nippon Enviro Chemicals Co., Ltd.) You can also
- inorganic oxide known or conventional inorganic oxides can be used and are not particularly limited.
- titania TiO 2
- zirconia ZrO 2
- magnesia MgO
- silica SiO 2
- Alumina Al 2 O 3
- a composite of two or more of these inorganic oxides eg, zeolite.
- at least one inorganic oxide (inorganic metal oxide) selected from the group consisting of titania, zirconia, magnesia, silica, and alumina is preferable.
- inorganic oxide examples include trade name “TIO-4” (titania, manufactured by Nippon Aerosil Co., Ltd.), trade name “500A” (produced by Ube Industries), trade name “G-6” (silica). , Fuji Silysia Chemical Co., Ltd.), trade name “KHO-24” (alumina, manufactured by Sumitomo Chemical Co., Ltd.), trade name “Zirconia” (manufactured by Wako Pure Chemical Industries, Ltd.) You can also
- the specific surface area of the support is not particularly limited, but the oxides and other metals described later are well dispersed, and aggregation of these can be suppressed, and the catalytic activity per unit weight can be improved. And 50 m 2 / g or more (for example, 50 to 1500 m 2 / g, preferably 100 to 1000 m 2 / g) is preferable. When the specific surface area of the carrier is less than the above range, the catalytic activity per unit weight tends to decrease.
- the average particle size of the carrier is not particularly limited, but is preferably from 100 to 10,000 ⁇ m, more preferably from 1000 to 10,000 ⁇ m, in view of reactivity and not accompanied by excessive pressure loss when the reaction is carried out in a continuous flow mode. 10,000 ⁇ m.
- the shape of the carrier may be any of powder, granule, molding (molded body) and the like, and is not particularly limited.
- the amount of the oxide supported on the carrier (when two or more oxides are included, the total amount thereof) (in terms of metal atoms (Group 6 element, Group 7 element) constituting the oxide) is particularly Although not limited, it is preferably 0.01 to 50% by weight, more preferably 0.01 to 20% by weight, still more preferably 0.5 to 15% by weight based on the total amount (100% by weight) of the oxide and the carrier. %, Particularly preferably 1.0 to 10% by weight. If the amount of the oxide supported is less than 0.01% by weight, the conversion of 1,4-anhydroerythritol may be reduced. On the other hand, if the amount of the oxide supported exceeds 50% by weight, it may be uneconomical such as a low yield per unit metal.
- the method of supporting the oxide on the carrier is not particularly limited, and the oxide can be supported on the carrier by a known or conventional supporting method.
- the carrier is impregnated with a solution containing the Group 6 element or Group 7 element constituting the oxide (for example, an aqueous solution of ammonium tungstate in the case of tungsten), and then dried. And further reduced as necessary (reducing the above metals (Group 6 element, Group 7 element)).
- the amount of the oxide supported can be controlled by adjusting the concentration of the solution containing the above Group 6 element or Group 7 element, the number of times the carrier is impregnated and dried. .
- the temperature at which the solution containing the Group 6 element or the Group 7 element is impregnated and the temperature at which the carrier impregnated with the solution is dried are not particularly limited.
- the temperature (firing temperature) when the metal (Group 6 element, Group 7 element) is further reduced after impregnating and drying a solution containing Group 6 element or Group 7 element is preferably 400 to 700 ° C., more preferably 450 to 550 ° C. in a hydrogen atmosphere.
- the above reduction treatment should be carried out particularly when a metal other than palladium and platinum is supported on the support as other metals described later, or when the other metal is not supported on the support. Is preferred.
- passivation may be performed as necessary.
- the handling of the catalyst (1) of the present invention tends to be easy.
- Passivation can be performed by a known or conventional method, and is not particularly limited.
- the passivation can be performed by exposure to an oxygen atmosphere at a temperature near room temperature.
- the catalyst (1) of the present invention preferably further contains a metal other than the Group 6 element and the Group 7 element (metal element: sometimes referred to as “other metal”) supported on the carrier.
- the catalyst (1) of the present invention is a catalyst comprising a support, the oxide supported on the support, and another metal supported on the support (therefore, the support (the same support) is described above). It is preferable that the oxide and the other metal are supported.
- the other metal is not particularly limited as long as it is a metal other than the Group 6 element and the Group 7 element.
- the catalyst (1) of the present invention contains other metal supported on the support, the conversion of 1,4-anhydroerythritol and the selectivity of 3-hydroxytetrahydrofuran tend to be further improved.
- the embodiment of the other metal contained in the catalyst (1) of the present invention is not particularly limited.
- the metal is supported on the carrier as a simple metal, a metal salt, a metal oxide, a metal hydroxide, or a metal complex. And the like are included.
- the method for supporting the other metal on the carrier is not particularly limited, and a known or conventional supporting method can be used. Specifically, for example, it can be supported in the same manner as the above-described method of supporting the oxide on the support, and after impregnating the support with a solution containing the other metal and drying, further, if necessary Reduction (reduction of other metals) and the like. More specifically, for example, impregnated with a solution containing a Group 6 element or a Group 7 element, and then impregnated with a solution containing the other metal to the carrier after drying, Examples of the method include a method of reducing after drying after drying.
- the temperature at which the solution containing the other metal is impregnated, the temperature at which the carrier impregnated with the solution is dried, and the temperature at which the other metal is reduced are not particularly limited.
- the reduction treatment after impregnating the solution containing the above Group 6 element or Group 7 element and the reduction treatment after impregnating the solution containing other metals include, for example, both solutions After impregnation, it can be carried out simultaneously by heating in a hydrogen atmosphere (for example, the heating temperature is preferably 400 to 700 ° C., more preferably 450 to 550 ° C.).
- the catalyst (1) of the present invention contains the other metal supported on the carrier, the group 6 element and the group 7 element constituting the oxide (the total amount of these elements when two or more kinds are contained) ) And other metals (the total amount of these when two or more are included) (molar ratio, metal conversion) [other metals / Group 6 elements and Group 7 elements] is particularly limited However, the ratio is preferably 50/1 to 1/500, more preferably 50/1 to 1/6, and still more preferably 4/1 to 1/4. The amount of the other metal used can be appropriately adjusted within the above range depending on the temperature and time for reacting 1,4-anhydroerythritol with hydrogen.
- the average particle diameter of the catalyst (1) of the present invention is not particularly limited, but is preferably 100 to 10,000 ⁇ m in terms of reactivity and not accompanied by excessive pressure loss when the reaction is carried out in a continuous flow mode. More preferably, the thickness is 1000 to 10,000 ⁇ m.
- the shape of the catalyst (1) of the present invention is not particularly limited, and examples thereof include powder, granule, molding (molded body) and the like.
- the hydrogenation reaction step A in the process for producing 3-hydroxytetrahydrofuran of the present invention is preferably carried out by reacting 1,4-anhydroerythritol with hydrogen in the presence of the catalyst (1) of the present invention. Is a step of generating.
- the reaction between 1,4-anhydroerythritol and hydrogen is performed by reacting gaseous (vaporized) 1,4-anhydroerythritol with hydrogen in the presence of the catalyst (1) (solid) of the present invention.
- the reaction may be a gas-solid two-phase reaction, or a gas-liquid solid three-phase reaction in which liquid 1,4-anhydroerythritol and hydrogen are reacted in the presence of the catalyst (1) (solid) of the present invention. It may be a reaction.
- the above reaction is preferably allowed to proceed in a gas-liquid solid three-phase system.
- the reaction of 1,4-anhydroerythritol and hydrogen in the hydrogenation reaction step A includes, for example, a raw material liquid containing 1,4-anhydroerythritol as an essential component and hydrogen in a reactor. It is possible to proceed by heating in the presence of the catalyst (1) of the present invention.
- the catalyst (1) of this invention can also be used individually by 1 type, and can also be used in combination of 2 or more type.
- the raw material liquid may contain, for example, a solvent such as water or an organic solvent, or may contain substantially no solvent.
- the organic solvent is not particularly limited, and examples thereof include alcohols such as methanol, ethanol, isopropanol, n-butanol, 2-butanol, dimethyl sulfoxide (DMSO), dimethylformamide (DMF), dimethylacetamide (DMAc), 1, 4-dioxane and the like can be mentioned.
- 1,4-dioxane is preferred as the raw material liquid because of its excellent reactivity between 1,4-anhydroerythritol and hydrogen.
- the raw material liquid a reaction mixture obtained by intramolecular dehydration reaction of erythritol in a dehydration reaction step described later, a solution obtained by removing an acid catalyst or the like from the reaction mixture as necessary, and the like can be used.
- the said solvent can also be used individually by 1 type, and can also be used in combination of 2 or more type.
- the concentration of 1,4-anhydroerythritol in the raw material liquid is not particularly limited, but is preferably 5 to 98% by weight, more preferably 8%. It is ⁇ 90 wt%, more preferably 10 to 90 wt%, particularly preferably 15 to 80 wt%.
- concentration of 1,4-anhydroerythritol is less than 5% by weight, the reaction rate (conversion rate) of 1,4-anhydroerythritol may decrease.
- the concentration of 1,4-anhydroerythritol exceeds 98% by weight, the viscosity increases and the operation may become complicated.
- the reaction between 1,4-anhydroerythritol and hydrogen may be allowed to proceed in the presence of a solid acid. That is, the raw material liquid may contain a solid acid in addition to the aforementioned 1,4-anhydroerythritol and the solvent.
- the solid acid is a solid exhibiting the characteristics of Bronsted acid and / or Lewis acid (either one or both of Bronsted acid and Lewis acid), and Hammett acidity function (H 0 ) is 6.8 or less. belongs to.
- the solid acid known or commonly used solid acids can be used, and are not particularly limited.
- inorganic acids and organic acids for example, silica, alumina, zeolite, silica-alumina, etc.
- Solids carrying organic sulfonic acids, etc . crystalline metal silicates such as gallium silicate, aluminosilicate, borosilicate (eg, H-ZSM-5 which is a proton type zeolite); heteropoly acids or salts thereof; carriers (eg, , Silica, alumina, etc.) solids carrying heteropolyacids or salts thereof; acidic metal oxides such as zirconium oxide (ZrO 2 ) and titanium oxide (TiO 2 ); having acid groups such as carboxyl groups and sulfonic acid groups Examples thereof include polymers (for example, cation exchange resins).
- a commercial item can also be utilized as said solid acid.
- the reaction By allowing the reaction to proceed in the presence of a solid acid, the above-described reaction between 1,4-anhydroerythritol and hydrogen can be promoted.
- the said solid acid can also be used individually by 1 type, and can also be used in combination of 2 or more type.
- the amount (content) of the solid acid is not particularly limited, but is preferably 0.1 to 50 parts by weight, more preferably 1 to 20 parts by weight with respect to 100 parts by weight of 1,4-anhydroerythritol. is there.
- a solid acid coexists, it is preferable to provide a step of removing the solid acid by filtration or the like after completion of the reaction.
- the raw material liquid may contain other components (for example, alcohols and the like) as long as the effects of the present invention are not impaired.
- the raw material liquid includes, for example, impurities derived from raw materials of 1,4-anhydroerythritol (erythritol, raw materials of the erythritol, etc.) (for example, long-chain fatty acids, metal salts, sulfur-containing compounds such as thiols and thioethers) , Nitrogen-containing compounds such as amines) may be contained, but since such impurities may deteriorate the catalyst, known or conventional methods (for example, distillation, adsorption, ion exchange, crystallization, extraction) Etc.) is preferably removed from the raw material liquid.
- the raw material liquid is not particularly limited, and can be obtained by mixing 1,4-anhydroerythritol with a solvent, a solid acid, and other components as necessary.
- a known or conventional stirrer can be used for mixing.
- the molar ratio of hydrogen to 1,4-anhydroerythritol [hydrogen (mol) / 1,4-anhydroerythritol (mol)] subjected to the above reaction is although not limited, it is preferably 1 to 100, more preferably 1 to 50, still more preferably 1 to 30. If the molar ratio is less than 1, the reaction rate (conversion rate) of 1,4-anhydroerythritol may decrease. On the other hand, when the molar ratio exceeds 100, the utility cost for recovering unreacted hydrogen tends to increase.
- the reaction temperature of 1,4-anhydroerythritol and hydrogen in the above reaction is not particularly limited, but is preferably 50 to 250 ° C, more preferably 60 to 220 ° C, and further preferably 70 to 200 ° C. If the reaction temperature is less than 50 ° C., the reaction rate (conversion rate) of 1,4-anhydroerythritol may be lowered. On the other hand, when the reaction temperature exceeds 250 ° C., 1,4-anhydroerythritol is likely to be decomposed (for example, carbon-carbon bond cleavage), and the yield of 3-hydroxytetrahydrofuran may decrease.
- the reaction temperature may be controlled to be constant (substantially constant) in the above reaction, or may be controlled to change stepwise or continuously.
- the reaction time of 1,4-anhydroerythritol and hydrogen in the above reaction is not particularly limited, but is preferably 0.1 to 100 hours, more preferably 0.2 to 80 hours, still more preferably 0.5 to 60 hours. It is. If the reaction time is less than 0.1 hour, the reaction rate (conversion rate) of 1,4-anhydroerythritol may not be sufficiently increased. On the other hand, when the reaction time exceeds 100 hours, the selectivity for 3-hydroxytetrahydrofuran may decrease.
- the reaction pressure of 1,4-anhydroerythritol and hydrogen in the above reaction is not particularly limited, but is preferably 1 to 50 MPa, more preferably 3 to 30 MPa. More preferably, it is 5 to 15 MPa. If the reaction pressure is less than 1 MPa, the reaction rate (conversion rate) of 1,4-anhydroerythritol may decrease. On the other hand, when the reaction pressure exceeds 50 MPa, the reactor needs to have a high pressure resistance, and thus the production cost tends to increase.
- the above reaction can be carried out in an arbitrary format such as a batch format, a semi-batch format, or a continuous distribution format.
- an arbitrary format such as a batch format, a semi-batch format, or a continuous distribution format.
- unreacted 1,4-anhydroerythritol after the reaction is separated and recovered and recycled.
- a process may be employed. If this recycling process is employed, the amount of 3-hydroxytetrahydrofuran produced when a predetermined amount of 1,4-anhydroerythritol is used can be increased.
- a known or conventional reactor can be used as the reactor, and for example, a batch reactor, a fluidized bed reactor, a fixed bed reactor, or the like can be used.
- a trickle bed reactor can be used as the fixed bed reactor.
- the trickle bed reactor has a catalyst packed bed filled with a solid catalyst inside, and the liquid (in the hydrogenation reaction step A, for example, the raw material liquid) and gas (hydrogenation reaction) with respect to the catalyst packed bed.
- the reactor is a reactor (fixed-bed continuous reaction apparatus) that flows in a downward flow (gas-liquid downward parallel flow) from above the reactor together with hydrogen.
- FIG. 1 is a flowchart showing an example of a hydrogenation reaction step A in a method for producing 3-hydroxytetrahydrofuran when a trickle bed reactor is used.
- 1 is a reactor (a trickle bed reactor)
- 2 is a feed line for raw material liquid
- 3 is a supply line for hydrogen.
- 4 is a reaction mixture take-out line
- 5 is a high-pressure gas-liquid separator
- 6 is a hydrogen recycle line.
- the raw material liquid and hydrogen are continuously supplied from above the trickle bed reactor 1, and then 1,4-anhydroerythritol and hydrogen in the raw material liquid are converted into the catalyst in the catalyst packed bed inside the reactor.
- the reaction is carried out in the presence of (the catalyst (1) of the present invention) to produce 3-hydroxytetrahydrofuran (reaction product).
- the reaction mixture containing 3-hydroxytetrahydrofuran is continuously taken out from the reaction mixture take-out line 4 below the trickle bed reactor 1, and then, if necessary, the reaction mixture is separated from the reaction mixture by a high-pressure gas-liquid separator 5.
- 3-hydroxytetrahydrofuran is purified and isolated in a purification step.
- the hydrogen separated by the high-pressure gas-liquid separator 5 can be supplied again to the trickle bed reactor 1 through the hydrogen recycling line 6 and reused for the reaction.
- Adopting a trickle bed reactor as the reactor is advantageous in terms of cost because the reaction can proceed in a gas-liquid solid three-phase system without vaporizing the raw material 1,4-anhydroerythritol. Also, in the trickle bed reactor, the raw material liquid containing 1,4-anhydroerythritol flows downward while forming a thin film on the catalyst surface, so the interface between the raw material liquid and hydrogen (gas-liquid interface) to the catalyst surface. , The diffusion of hydrogen dissolved in the raw material liquid to the catalyst surface is facilitated, and 3-hydroxytetrahydrofuran can be efficiently produced. In addition, a process for separating the catalyst from the reaction product of 1,4-anhydroerythritol and hydrogen is not necessary, and the catalyst regeneration process is easy. Therefore, the production process is simple and the cost is excellent.
- the material, shape, size, etc. are not particularly limited, and are selected from known or conventional trickle bed reactors depending on the scale of the reaction, etc. It can be selected appropriately.
- the trickle bed reactor may be constituted by a single reaction tube or a multi-stage reactor constituted by a plurality of reaction tubes.
- the number of reaction tubes can be selected as appropriate and is not particularly limited.
- the reactor may be one in which a plurality of reaction tubes are installed in series, or a plurality of reaction tubes are arranged in parallel. It may be a thing.
- the catalyst packed bed inside the trickle bed reactor may be divided (separated) into two or more positions, for example, in order to suppress overheating due to reaction heat.
- 3-hydroxytetrahydrofuran is produced as a reaction product of the reaction between 1,4-anhydroerythritol and hydrogen.
- 3-hydroxytetrahydrofuran is represented by the following formula (2).
- the method for producing 3-hydroxytetrahydrofuran of the present invention may include other steps as necessary.
- Other steps include, for example, a step of preparing and purifying the raw material liquid before supplying the raw material liquid and hydrogen to the reactor, and a reaction mixture discharged (outflowed) from the reactor (for example, 1,4-anhydrous).
- a step of separating and purifying a mixture of products such as erythritol, hydrogen, and 3-hydroxytetrahydrofuran.
- the method for producing 3-hydroxytetrahydrofuran of the present invention may include, for example, a step of generating 1,4-anhydroerythritol as a raw material in the step before the hydrogenation reaction step A.
- the step of producing 1,4-anhydroerythritol is particularly preferably a step of producing 1,4-anhydroerythritol by an intramolecular dehydration reaction of erythritol (sometimes referred to as “dehydration reaction step”).
- the intramolecular dehydration reaction of erythritol in the dehydration reaction step can be carried out by a well-known method and is not particularly limited. For example, it can be advanced by heating erythritol in the presence of an acid catalyst.
- the dehydration reaction step may be performed in a separate line from the hydrogenation reaction step A, or may be performed as a series of steps with the hydrogenation reaction step A.
- the erythritol used as a raw material in the dehydration reaction step is not particularly limited, and may be erythritol produced by chemical synthesis or erythritol derived from a sugar such as glucose by a fermentation technique. Among these, from the viewpoint of reducing the burden on the environment, it is preferable to use erythritol derived from a saccharide such as glucose by a fermentation technique. In addition, erythritol (unreacted erythritol) recovered from the reaction mixture obtained by the dehydration reaction step can be reused.
- the acid catalyst used in the dehydration reaction step may be a known or conventional acid, and is not particularly limited.
- hydrochloric acid sulfuric acid, nitric acid, phosphoric acid, polyphosphoric acid, metaphosphoric acid, condensed phosphoric acid.
- Inorganic acids such as hydrobromic acid, perchloric acid, hypochlorous acid and chlorous acid; organic acids such as p-toluenesulfonic acid, trichloroacetic acid, trifluoroacetic acid and trifluoromethanesulfonic acid; cation exchange resin, Examples thereof include solid acids such as zeolite, silica alumina, and heteropolyacid (for example, phosphomolybdic acid).
- a solid acid is preferable because it can be easily separated from a product and regenerated.
- a commercial item can also be used as said acid catalyst, for example, a brand name "Amberlyst” (made by Dow Chemical), a brand name "Nafion” (made by DuPont Co., Ltd.), etc. as a commercial item of a solid acid. Is exemplified.
- an acid (acid catalyst) can also be used individually by 1 type, and can also be used in combination of 2 or more type.
- the above reaction can be allowed to proceed in the absence of a solvent, or can be allowed to proceed in the presence of a solvent.
- the solvent include water; alcohols such as methanol, ethanol, isopropanol, and n-butanol; highly polar organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and dimethylacetamide (DMAc). .
- DMSO dimethyl sulfoxide
- DMF dimethylformamide
- DMAc dimethylacetamide
- a solvent can also be used individually by 1 type and can also be used in combination of 2 or more type.
- the reaction temperature (heating temperature) of the above reaction is not particularly limited, but is preferably 40 to 240 ° C, more preferably 80 to 200 ° C, and still more preferably 120 to 180 ° C. By controlling the reaction temperature within the above range, the intramolecular dehydration reaction of erythritol can proceed more efficiently.
- the reaction temperature may be controlled to be constant (substantially constant) in the reaction, or may be controlled to change stepwise or continuously.
- the time (reaction time) for the above reaction is not particularly limited, but is preferably 1 to 100 hours, more preferably 2 to 50 hours, still more preferably 3 to 30 hours. If the reaction time is less than 1 hour, the reaction rate (conversion rate) of erythritol may not be sufficiently increased. On the other hand, if the reaction time exceeds 100 hours, it may be disadvantageous in terms of cost.
- the above reaction can be carried out in any atmosphere such as an air atmosphere or an inert gas atmosphere such as nitrogen or argon.
- an inert gas atmosphere such as nitrogen or argon.
- the above reaction can be carried out under normal pressure, under pressure, or under reduced pressure.
- it is preferably carried out under pressure.
- the reaction temperature can be raised to 100 ° C. or higher by carrying out the reaction under pressure, so that the conversion rate of erythritol can be increased efficiently.
- the above reaction can be carried out in any format such as a batch format, a semi-batch format, and a continuous flow format.
- the 1,4-anhydroerythritol is produced by the dehydration reaction step.
- the 1,4-anhydroerythritol thus obtained is then used as a raw material in the hydrogenation reaction step A, and is known or commonly used from the reaction mixture obtained in the dehydration reaction step (for example, Distillation, adsorption, ion exchange, crystallization, extraction, etc.) can be used after isolation, or without isolation from the above reaction mixture (after removing acid catalyst, etc., if necessary) You can also
- the method for producing 1,3-butanediol of the present invention comprises a step of producing 1,3-butanediol by the reaction of 3-hydroxytetrahydrofuran and hydrogen (sometimes referred to as “hydrogenation reaction step B”). It is characterized by including as an essential process.
- the use of 3-hydroxytetrahydrofuran (3-hydroxytetrahydrofuran produced by reaction of 1,4-anhydroerythritol and hydrogen) obtained by the former method can contribute to the reduction of environmental burden. it can.
- the hydrogen (hydrogen gas) used in the hydrogenation reaction step B can be used in a substantially hydrogen-only state, or used in a state diluted with an inert gas such as nitrogen, argon or helium. You can also In addition, hydrogen recovered from the reaction mixture obtained as a result of the hydrogenation reaction step B (unreacted hydrogen) can be reused.
- the reaction of 3-hydroxytetrahydrofuran with hydrogen in the hydrogenation reaction step B is a catalyst (hydrogen of 3-hydroxytetrahydrofuran used for the reaction for producing 1,3-butanediol by the reaction of 3-hydroxytetrahydrofuran with hydrogen. It is preferable to proceed in the presence of a catalyst for the oxidization reaction). By using a catalyst, the above reaction is promoted, the conversion of 3-hydroxytetrahydrofuran is improved, and the selectivity of 1,3-butanediol tends to be improved.
- iridium Ir
- rhenium Re
- ruthenium Ru
- molybdenum Mo
- the iridium and the like in the catalyst (2) of the present invention may be supported on a carrier, and the form (state) is not particularly limited.
- the form of iridium examples include a form of a simple metal, a metal salt, a metal oxide, a metal hydroxide, a metal complex, and the like.
- the catalyst (2) of the present invention preferably contains at least iridium or rhenium supported on a support from the viewpoint of the reactivity of the reaction between 3-hydroxytetrahydrofuran and hydrogen, and iridium and rhenium supported on the support. It is particularly preferable that at least be included.
- the carrier can be a known or conventional carrier used as a catalyst carrier, and is not particularly limited. Examples thereof include inorganic carriers such as inorganic oxides and activated carbon, and organic carriers such as ion exchange resins. Can be mentioned.
- an inorganic oxide is preferable because it has excellent reaction activity. Examples of the inorganic oxide include silica (SiO 2 ), titania (TiO 2 ), zirconia (ZrO 2 ), alumina (Al 2 O 3 ), magnesia (MgO), and two or more kinds of these inorganic oxides.
- a composite for example, zeolite etc.) etc. are mentioned.
- the inorganic oxides at least one inorganic oxide selected from the group consisting of silica, magnesia, titania, and alumina is particularly preferable in terms of excellent reaction activity.
- the carrier can be used singly or in combination of two or more.
- the specific surface area of the carrier is not particularly limited, can be arranged iridium in a highly dispersed, it is possible to suppress aggregation of the metal, in that it is possible to improve the catalytic activity per unit weight, 50 m 2 / g or more (for example, 50 to 1500 m 2 / g, preferably 100 to 1000 m 2 / g) is preferable.
- the specific surface area of the carrier is less than the above range, the catalytic activity per unit weight tends to decrease.
- the average particle size of the carrier is not particularly limited, but is preferably from 100 to 10,000 ⁇ m, more preferably from 1000 to 10,000 ⁇ m, in view of reactivity and not accompanied by excessive pressure loss when the reaction is carried out in a continuous flow mode. 10,000 ⁇ m.
- the shape of the carrier may be any of powder, granule, molding (molded body) and the like, and is not particularly limited.
- the amount of iridium or the like supported on the carrier (when two or more metals are included, the total amount thereof) (in terms of metal atoms) is not particularly limited, but relative to the total amount of iridium and the carrier and the carrier (100% by weight)
- the content is preferably 0.01 to 50% by weight, more preferably 0.01 to 20% by weight, still more preferably 0.5 to 15% by weight, and particularly preferably 1.0 to 10% by weight. If the supported amount of iridium or the like is less than 0.01% by weight, the conversion rate of 3-hydroxytetrahydrofuran tends to decrease. On the other hand, if the amount of iridium or the like exceeds 50% by weight, it may be uneconomical.
- the method for supporting the iridium or the like (particularly, iridium) on the carrier is not particularly limited, and a known or conventional supporting method can be used. Specifically, for example, it can be supported by a method of impregnating a carrier with a solution containing iridium or the like (for example, an aqueous solution of chloroiridic acid in the case of iridium), then drying and then firing. Note that the amount of iridium or the like supported can be controlled by adjusting the concentration of the solution containing iridium or the like, the number of times the carrier is impregnated, and dried.
- a solution containing iridium or the like for example, an aqueous solution of chloroiridic acid in the case of iridium
- the temperature at which the solution containing iridium or the like is impregnated and the temperature at which the carrier impregnated with the solution is dried are not particularly limited.
- the support can be supported by the above method using two or more kinds of solutions containing iridium or the like.
- the temperature (calcination temperature) at which the carrier after impregnating and drying the solution containing iridium or the like is calcined is not particularly limited, but is preferably 400 to 700 ° C., more preferably 450 to 700 ° C. in the atmosphere. 550 ° C.
- the atmosphere at the time of baking is not limited to air
- the ratio of iridium and rhenium (molar ratio, metal conversion) [iridium / rhenium] is not particularly limited, but 3- From the viewpoint of the conversion rate of hydroxytetrahydrofuran, 50/1 to 1/6 is preferable, more preferably 4/1 to 1/4, and still more preferably 3/1 to 1/3.
- the average particle size of the catalyst (2) of the present invention is not particularly limited, but is preferably 100 to 10,000 ⁇ m in terms of reactivity and not accompanied by excessive pressure loss when the reaction is carried out in a continuous flow mode. More preferably, the thickness is 1000 to 10,000 ⁇ m.
- the shape of the catalyst (2) of the present invention is not particularly limited, and examples thereof include powder, granule, molding (molded body) and the like.
- 1,3-butanediol is preferably reacted by reacting 3-hydroxytetrahydrofuran with hydrogen in the presence of the catalyst (2) of the present invention. It is a process of generating.
- the reaction between 3-hydroxytetrahydrofuran and hydrogen is a gas-solid two-phase system in which gaseous (vaporized) 1,3-hydroxytetrahydrofuran and hydrogen are reacted in the presence of the catalyst (2) (solid) of the present invention.
- a gas-liquid solid three-phase reaction in which liquid 3-hydroxytetrahydrofuran and hydrogen are reacted in the presence of the catalyst (2) (solid) of the present invention.
- the above reaction is preferably allowed to proceed in a gas-liquid solid three-phase system.
- the reaction between 3-hydroxytetrahydrofuran and hydrogen in the hydrogenation reaction step B is performed by, for example, enclosing a raw material liquid containing 3-hydroxytetrahydrofuran as an essential component and hydrogen in a reactor, It can proceed by heating in the presence of catalyst (2).
- the catalyst (2) of the present invention can be used singly or in combination of two or more.
- the raw material liquid may contain, for example, a solvent such as water or an organic solvent in addition to 3-hydroxytetrahydrofuran, or may contain substantially no solvent.
- the organic solvent is not particularly limited, and examples thereof include alcohols such as methanol, ethanol, isopropanol, n-butanol and 2-butanol, dimethyl sulfoxide (DMSO), dimethylformamide (DMF), dimethylacetamide (DMAc) and the like. Examples include polar organic solvents.
- the raw material liquid preferably contains at least water as a solvent in terms of excellent reactivity and easy handling and disposal.
- a solvent can also be used individually by 1 type and can also be used in combination of 2 or more type.
- the concentration of 3-hydroxytetrahydrofuran in the raw material liquid is not particularly limited, but is preferably 5 to 98% by weight, more preferably 8 to 90% by weight, The amount is preferably 10 to 90% by weight, particularly preferably 15 to 80% by weight. If the concentration of 3-hydroxytetrahydrofuran is less than 5% by weight, the reaction rate (conversion rate) of 3-hydroxytetrahydrofuran may decrease. On the other hand, when the concentration of 3-hydroxytetrahydrofuran exceeds 98% by weight, the viscosity increases and the operation may become complicated.
- the above-mentioned reaction between 3-hydroxytetrahydrofuran and hydrogen may proceed in the presence of an acid. That is, the raw material liquid may contain an acid in addition to the above-mentioned 3-hydroxytetrahydrofuran and the solvent.
- the acid is not particularly limited, and examples thereof include known or commonly used acids such as sulfuric acid, phosphoric acid, trifluoromethanesulfonic acid and the like.
- an acid can also be used individually by 1 type, and can also be used in combination of 2 or more type.
- the amount of the acid used (content) is not particularly limited, but is 0.1 to 10 mol times relative to iridium and the like contained in the catalyst (in terms of metal, the total amount of these when two or more are included). And more preferably 0.5 to 3 mole times.
- an acid is allowed to coexist, it is preferable to provide a step of neutralizing the acid after completion of the reaction.
- the raw material liquid may contain other components (for example, alcohols and the like) as long as the effects of the present invention are not impaired.
- the raw material liquid include impurities derived from 3-hydroxytetrahydrofuran raw materials (erythritol, 1,4-anhydroerythritol, and these raw materials) (for example, long-chain fatty acids, metal salts, thiols, thioethers, etc.) Sulfur-containing compounds, nitrogen-containing compounds such as amines, etc.), but since these impurities may deteriorate the catalyst, known or conventional methods (for example, distillation, adsorption, ion exchange, It is preferable to remove from the raw material liquid by crystallization, extraction or the like.
- the raw material liquid is not particularly limited, and can be obtained by uniformly mixing 3-hydroxytetrahydrofuran with a solvent, an acid, and other components as necessary.
- a known or conventional stirrer can be used for mixing.
- the molar ratio [hydrogen (mol) / 3-hydroxytetrahydrofuran (mol)] of hydrogen and 3-hydroxytetrahydrofuran to be subjected to the reaction is not particularly limited, but is preferably 1 to 100, More preferably, it is 1.5-50, and more preferably 2-30. If the molar ratio is less than 1, the reaction rate (conversion rate) of 3-hydroxytetrahydrofuran may decrease. On the other hand, when the molar ratio exceeds 100, the utility cost for recovering unreacted hydrogen tends to increase.
- the reaction temperature of 3-hydroxytetrahydrofuran and hydrogen in the above reaction is not particularly limited, but is preferably 50 to 200 ° C, more preferably 60 to 150 ° C, and further preferably 70 to 130 ° C. If the reaction temperature is less than 50 ° C., the reaction rate (conversion rate) of 3-hydroxytetrahydrofuran may decrease. On the other hand, when the reaction temperature exceeds 200 ° C., decomposition of 3-hydroxytetrahydrofuran (for example, carbon-carbon bond cleavage) tends to occur, and the selectivity for 1,3-butanediol may decrease.
- the reaction temperature may be controlled to be constant (substantially constant) in the above reaction, or may be controlled to change stepwise or continuously.
- the reaction time of 3-hydroxytetrahydrofuran and hydrogen in the above reaction is not particularly limited, but is preferably 0.1 to 100 hours, more preferably 0.2 to 10 hours, and further preferably 0.5 to 8 hours. If the reaction time is less than 0.1 hour, the reaction rate (conversion rate) of 3-hydroxytetrahydrofuran may not be sufficiently increased. On the other hand, when the reaction time exceeds 100 hours, the selectivity for 1,3-butanediol may decrease.
- the reaction pressure of 3-hydroxytetrahydrofuran and hydrogen in the above reaction is not particularly limited, but is preferably 1 to 50 MPa, more preferably 3 to 30 MPa, still more preferably 5 to 15 MPa. If the reaction pressure is less than 1 MPa, the reaction rate (conversion rate) of 3-hydroxytetrahydrofuran may decrease. On the other hand, when the reaction pressure exceeds 50 MPa, the reactor needs to have a high pressure resistance, and thus the production cost tends to increase.
- the above reaction can be carried out in an arbitrary format such as a batch format, a semi-batch format, or a continuous distribution format.
- a process for separating and recovering unreacted 3-hydroxytetrahydrofuran after completion of the reaction and recycling it is adopted. May be. If this recycling process is employed, the amount of 1,3-butanediol produced when a predetermined amount of 3-hydroxytetrahydrofuran is used can be increased.
- FIG. 1 is also a flow chart showing an example of a hydrogenation reaction step B in a method for producing 1,3-butanediol when a trickle bed reactor is used.
- a method for producing 1,3-butanediol using a trickle bed reactor will be briefly described with reference to FIG.
- a raw material liquid and hydrogen are continuously supplied from above the trickle bed reactor 1, and then 3-hydroxytetrahydrofuran and hydrogen in the raw material liquid are supplied inside the reactor in the presence of the catalyst in the catalyst packed bed.
- the reaction mixture containing 1,3-butanediol is continuously taken out from the reaction mixture take-out line 4 below the trickle bed reactor 1, and then, if necessary, the reaction mixture is taken up by the high-pressure gas-liquid separator 5.
- the high-pressure gas-liquid separator 5 After separating hydrogen from 1,3-butanediol is purified and isolated in a purification step.
- the hydrogen separated by the high-pressure gas-liquid separator 5 can be supplied again to the trickle bed reactor 1 through the hydrogen recycling line 6 and reused for the reaction.
- Adopting a trickle bed reactor as the reactor is advantageous in terms of cost because the reaction can proceed in a gas-liquid solid three-phase system without vaporizing the raw material 3-hydroxytetrahydrofuran. Further, in the trickle bed reactor, the raw material liquid containing 3-hydroxytetrahydrofuran flows downward while forming a thin film on the catalyst surface, so the distance from the raw material liquid-hydrogen interface (gas-liquid interface) to the catalyst surface is small. It is short and facilitates diffusion of hydrogen dissolved in the raw material liquid to the catalyst surface, and 1,3-butanediol can be efficiently produced. In addition, a process for separating the catalyst from the reaction product of 3-hydroxytetrahydrofuran and hydrogen is not required, and the catalyst regeneration process is easy. Therefore, the manufacturing process is simple and the cost is excellent.
- the material, shape, size, etc. are not particularly limited, and are selected from known or conventional trickle bed reactors depending on the scale of the reaction, etc. It can be selected appropriately.
- the trickle bed reactor may be constituted by a single reaction tube or a multistage reactor constituted by a plurality of reaction tubes.
- the number of reaction tubes can be selected as appropriate and is not particularly limited.
- the reactor may be one in which a plurality of reaction tubes are installed in series, or a plurality of reaction tubes are arranged in parallel. It may be a thing.
- the catalyst packed bed inside the trickle bed reactor may be divided (separated) into two or more positions, for example, in order to suppress overheating due to reaction heat.
- the method for producing 1,3-butanediol of the present invention may include other steps as necessary.
- Other steps include, for example, a step of preparing and purifying the raw material liquid before supplying the raw material liquid and hydrogen to the reactor, and a reaction mixture discharged (outflowed) from the reactor (eg, 3-hydroxytetrahydrofuran, hydrogen And a mixture of 1,3-butanediol and the like). Note that these steps may be performed in a separate line from the hydrogenation reaction step B, or may be performed as a series of steps (in-line) with the hydrogenation reaction step B.
- the method for producing 1,3-butanediol of the present invention may include, for example, before the hydrogenation reaction step B, a step of producing 3-hydroxytetrahydrofuran as a raw material in this step.
- a step of producing 3-hydroxytetrahydrofuran include hydrogenation reaction step A (or dehydration reaction step and hydrogenation reaction step A) in the above-described method for producing 3-hydroxytetrahydrofuran of the present invention.
- Example 1a [Production of catalyst (9.9 wt% WO x / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Next, carbon black (trade name “Vulcan XC72”, manufactured by CABOT) 0.9013 g was added to the total amount of the above aqueous solution in 5 portions so as to prevent liquid accumulation, and heated and stirred at 70 to 90 ° C. for impregnation. I let you. After impregnation, it was dried overnight at 110 ° C. in a dryer.
- ammonium tungstate manufactured by Wako Pure Chemical Industries, Ltd.
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 500 ° C.
- the reduction treatment was carried out while maintaining the same temperature for 30 minutes. Then, over a period of 30 minutes and cooled to room temperature, then, by switching the hydrogen 2% oxygen (balance He) gas, 2 hours passivation was performed to obtain a catalyst (9.9wt% WO X / C) .
- Example 2a [Production of catalyst (9.9 wt% WO x -Pd / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 0.2818 g of an aqueous palladium (II) nitrate solution (Pd: 5.07%, manufactured by NV Chemcat) was diluted with 5 mL of distilled water was prepared.
- II aqueous palladium
- the total amount of the above ammonium tungstate aqueous solution was added in 5 portions to 0.8870 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT Co., Ltd.), and the mixture was heated and stirred at 70 to 90 ° C. And impregnated. After drying this at 110 ° C. overnight in a dryer, add the entire amount of the above diluted aqueous solution of palladium (II) in two portions so that the liquid does not accumulate, and heat and stir at 70 to 90 ° C. Impregnated. After impregnation, the catalyst was dried in a dryer at 110 ° C. overnight to obtain a catalyst (9.9 wt% WO x -Pd / C).
- Example 3a [Production of catalyst (9.9 wt% WO x -Pt / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, a solution in which 0.0528 g of bis (acetylacetonato) platinum was dissolved in 5 mL of acetone was prepared.
- Example 4a [Production of catalyst (9.9 wt% WO x -Fe / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 0.0542 g of iron (III) nitrate nonahydrate was dissolved in 5 mL of water was prepared.
- the total amount of the above ammonium tungstate aqueous solution was added in 5 portions to 0.8938 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT Co., Ltd.), and the mixture was heated and stirred at 70 to 90 ° C. And impregnated. After drying this at 110 ° C overnight in a dryer, add the entire amount of the iron nitrate (III) aqueous solution in two portions so that the liquid does not accumulate, and heat and stir at 70 to 90 ° C to impregnate. I let you. After impregnation, it was dried overnight at 110 ° C. in a dryer.
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 500 ° C.
- the reduction treatment was carried out while maintaining the same temperature for 30 minutes. Thereafter, the mixture was cooled to room temperature over 30 minutes, and then hydrogen was switched to 2% oxygen (balanced He) gas and passivation was performed for 2 hours to obtain a catalyst (9.9 wt% WO x —Fe / C).
- Example 5a [Production of catalyst (9.9 wt% WO x -Co / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 0.0391 g of cobalt (II) nitrate hexahydrate was dissolved in 5 mL of water was prepared.
- the carbon black (trade name “Vulcan XC72”, manufactured by CABOT) 0.8938 g
- the total amount of the above ammonium tungstate aqueous solution was added in 5 portions so as to prevent accumulation of liquid, and heated and stirred at 70 to 90 ° C. And impregnated. After drying this at 110 ° C. overnight in a dryer, add the entire amount of the above cobalt (II) nitrate solution in two portions so as to prevent accumulation of liquid, and heat and stir at 70 to 90 ° C. for impregnation. I let you. After impregnation, it was dried overnight at 110 ° C. in a dryer.
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 500 ° C.
- the reduction treatment was carried out while maintaining the same temperature for 30 minutes. Then, it was cooled to room temperature over 30 minutes, and then hydrogen was switched to 2% oxygen (balanced He) gas, and passivation was performed for 2 hours to obtain a catalyst (9.9 wt% WO x —Co / C). .
- Example 6a [Production of catalyst (9.9 wt% WO x -Ni / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. In addition, an aqueous solution in which 0.0391 g of nickel (II) nitrate hexahydrate was dissolved in 5 mL of water was prepared.
- the total amount of the above ammonium tungstate aqueous solution was added in 5 portions to 0.8934 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT) so as to prevent the accumulation of liquid, and heated and stirred at 70 to 90 ° C. And impregnated. After drying this overnight at 110 ° C. in a dryer, add the entire amount of the above nickel (II) nitrate solution in two portions so that the liquid does not accumulate, and heat and stir at 70 to 90 ° C. to impregnate. Let After impregnation, it was dried overnight at 110 ° C. in a dryer.
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 500 ° C.
- the reduction treatment was carried out while maintaining the same temperature for 30 minutes. Thereafter, the mixture was cooled to room temperature over 30 minutes, and then hydrogen was switched to 2% oxygen (balanced He) gas and passivation was performed for 2 hours to obtain a catalyst (9.9 wt% WO x —Ni / C).
- Example 7a [Production of catalyst (9.9 wt% WO x -Cu / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 0.0324 g of copper (II) nitrate trihydrate was dissolved in 5 mL of water was prepared.
- the total amount of the above ammonium tungstate aqueous solution was added in 5 portions to 0.8927 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT Co., Ltd.) so as to prevent liquid accumulation, and heated and stirred at 70 to 90 ° C. And impregnated. After drying this at 110 ° C. overnight in a dryer, add the entire amount of the above copper nitrate (II) aqueous solution in two portions so as to prevent accumulation of liquid, and heat and stir at 70 to 90 ° C. to impregnate. I let you. After impregnation, it was dried overnight at 110 ° C. in a dryer.
- carbon black trade name “Vulcan XC72”, manufactured by CABOT Co., Ltd.
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and after reaching 500 ° C., for 30 min.
- the reduction treatment was carried out while maintaining the same temperature. Thereafter, the mixture was cooled to room temperature over 30 minutes, and then hydrogen was switched to 2% oxygen (balanced He) gas and passivation was performed for 2 hours to obtain a catalyst (9.9 wt% WO x —Cu / C). .
- Example 1-1 [Production of 3-hydroxytetrahydrofuran] A glass autoclave inner cylinder with a stirrer chip, 150 mg of the weighed catalyst (9.9 wt% WO x / C) obtained in Example 1a, 4 g of 1,4-dioxane, and 1,4-anhydroerythritol 1 g was added. The autoclave inner cylinder was placed in a 190 mL autoclave and capped. Next, the operation of evacuating after filling 1 MPa of hydrogen into the autoclave was repeated three times to expel the air inside the autoclave. This autoclave was filled with hydrogen so that the reaction temperature was 8 ° C. at 180 ° C. and 5 MPa at room temperature.
- the autoclave was set in a magnetic stirrer heating apparatus and heated for 16 hours while heating so that the temperature inside the reactor (inside the autoclave) was 180 ° C. Then, it cooled to room temperature, the hydrogen inside an autoclave was released, and it released pressure.
- the solution after the reaction was analyzed using gas chromatography (gas chromatograph apparatus: “GC-2014” (manufactured by Shimadzu Corporation), GC column: TC-WAX, DB-FFAP, detector: FID). From this, the conversion rate of 1,4-anhydroerythritol and the selectivity of the product were calculated. The analysis results are shown in Table 2.
- Examples 1-2 to 1-7 The production of 3-hydroxytetrahydrofuran was carried out in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 1. The results are shown in Table 2.
- the temperature described in the column of “reduction treatment” in Table 1 indicates the temperature of the reduction treatment at the time of catalyst production.
- “None” in the column of “Reduction treatment” in Table 1 means that the reduction treatment was not performed during the production of the catalyst, and the same applies to the following examples.
- M / W in Table 1 means the ratio (molar ratio) between tungsten (W) supported on the carrier and metal (M) other than tungsten.
- Example 8a Production of catalyst (9.9 wt% WO x / C BP2000)
- the catalyst 9.9wt% WO X / C
- Example 9a [Production of catalyst (9.9 wt% WO x / C Shirasagi FAC-10)] Example 1a except that 0.9013 g of the trade name “Shirasagi FAC-10” (carbon black, manufactured by Nippon Enviro Chemicals Co., Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT). In the same manner as above, a catalyst (9.9 wt% WO x / C) was obtained.
- Example 10a [Production of catalyst (9.9 wt% WO x / C Shirasagi M)] The same as Example 1a except that 0.9013 g of the trade name “Shirasagi M” (carbon black, manufactured by Nippon Environmental Chemicals Co., Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT). Thus, a catalyst (9.9 wt% WO x / C) was obtained.
- Example 11a [Production of catalyst (9.9 wt% WO x / C Shirasagi C)] The same as Example 1a except that 0.9013 g of the trade name “Shirasagi C” (carbon black, manufactured by Nippon Environmental Chemicals Co., Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT). Thus, a catalyst (9.9 wt% WO x / C) was obtained.
- Example 12a [Production of catalyst (9.9 wt% WO X / C Carraffin)]
- Example 1a was used except that 0.9013 g of the product name “Carboraffin” (carbon black, manufactured by Nippon Environmental Chemicals Co., Ltd.) was used instead of the product name “Vulcan XC72” (carbon black, manufactured by CABOT).
- a catalyst (9.9 wt% WO x / C) was obtained.
- Example 13a [Production of catalyst (9.9 wt% WO x / TiO 2 )]
- Example 1a was used except that 0.9013 g of the trade name “TIO-4” (Titania, Nippon Aerosil Co., Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT).
- TIO-4 Tiania, Nippon Aerosil Co., Ltd.
- Vulcan XC72 carbon black, manufactured by CABOT
- Example 14a Production of catalyst (9.9 wt% WO x / ZrO 2 )] In the same manner as in Example 1a except that 0.9013 g of zirconia (manufactured by Wako Pure Chemical Industries, Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT), a catalyst (9. 9wt% WO X / ZrO 2) was obtained.
- Example 15a [Production of catalyst (9.9 wt% WO x / MgO)] Example 1a except that 0.9013 g of the trade name “500A” (magnesia, Ube Industries, Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT). A catalyst (9.9 wt% WO x / MgO) was obtained.
- Example 16a [Production of catalyst (9.9 wt% WO x / SiO 2 )] Example 1a except that 0.9013 g of the trade name “G-6” (silica, manufactured by Fuji Silysia Chemical Co., Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT). There was obtained a catalyst (9.9wt% WO X / SiO 2 ).
- Example 17a [Production of catalyst (9.9 wt% WO x / Al 2 O 3 )]
- Example 1a was used except that 0.9013 g of the trade name “KHO-24” (alumina, manufactured by Sumitomo Chemical Co., Ltd.) was used instead of the trade name “Vulcan XC72” (carbon black, manufactured by CABOT).
- KHO-24 alumina, manufactured by Sumitomo Chemical Co., Ltd.
- Vulcan XC72 carbon black, manufactured by CABOT
- Examples 2-1 to 2-11 3-hydroxytetrahydrofuran was produced in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 3. The results are shown in Table 4.
- Example 19a [Production of catalyst (9.9 wt% WO x -Pd / TiO 2 )] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 4.0588 g of an aqueous palladium (II) nitrate solution (Pd: 5.07%, manufactured by NP Chemcat) was diluted with 5 mL of distilled water was prepared.
- II aqueous palladium
- KHO-24 alumina, manufactured by Sumitomo Chemical Co., Ltd.
- Example 21a [Production of catalyst (9.9 wt% WO x -Pd / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 4.0588 g of an aqueous palladium (II) nitrate solution (Pd: 5.07%, manufactured by NP Chemcat) was diluted with 5 mL of distilled water was prepared.
- II aqueous palladium
- the total amount of the above ammonium tungstate aqueous solution is added in 5 portions to 0.8870 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT) so that the liquid does not accumulate, and heated and stirred at 70 to 90 ° C. And impregnated. After drying this at 110 ° C. overnight in a dryer, add the entire amount of the above diluted aqueous solution of palladium (II) in two portions so that the liquid does not accumulate, and heat and stir at 70 to 90 ° C. Impregnated. After impregnation, it was dried overnight at 110 ° C. in a dryer.
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 500 ° C.
- Example 22a [Production of catalyst (9.9 wt% WO x -Pd / TiO 2 )] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 4.0588 g of an aqueous palladium (II) nitrate solution (Pd: 5.07%, manufactured by NP Chemcat) was diluted with 5 mL of distilled water was prepared.
- II aqueous palladium
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 500 ° C.
- KHO-24 alumina, manufactured by Sumitomo Chemical Co., Ltd.
- Examples 3-1 to 3-6 3-hydroxytetrahydrofuran was produced in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 5. The results are shown in Table 6.
- W / Pd in Table 5 means the ratio (molar ratio) between tungsten (W) and palladium (Pd) supported on the carrier.
- Example 24a [Production of catalyst (3.3 wt% WO x -Pd / C)] Except that the amount of ammonium tungstate used was changed to 0.0467 g and the amount of palladium nitrate (II) aqueous solution used was changed to 0.0939 g, a catalyst (3.3 wt% WO x ⁇ Pd / C) was obtained.
- Example 25a [Production of catalyst (6.6 wt% WO x -Pd / C)] Except that the amount of ammonium tungstate used was changed to 0.0935 g and the amount of palladium nitrate (II) aqueous solution used was changed to 0.1879 g, a catalyst (6.6 wt% WO x ⁇ Pd / C) was obtained.
- Example 26a [Production of catalyst (13.2 wt% WO x -Pd / C)] Except that the amount of ammonium tungstate used was changed to 0.1869 g and the amount of palladium nitrate aqueous solution used was changed to 2.1879 g, the catalyst (13.2 wt% WO x ⁇ Pd / C) was obtained.
- Examples 4-1 to 4-4 3-hydroxytetrahydrofuran was produced in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 7.
- the results are shown in Table 8.
- “Pd / W” in Table 7 means the ratio (molar ratio) between tungsten (W) and palladium (Pd) supported on the carrier, and the same applies to the following.
- Example 33a [Production of catalyst (1.4 wt% Pd / C)] 0.2818 g of palladium (II) nitrate aqueous solution (Pd: 5.07%) was diluted with 5 mL of distilled water to prepare an aqueous solution. Next, the above aqueous solution was added in three portions to 0.9857 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT Co., Ltd.) so as to prevent liquid accumulation, and impregnated by heating and stirring at 70 to 90 ° C. It was. After impregnation, the catalyst (1.4 wt% Pd / C) was obtained by drying overnight at 110 ° C. in a dryer.
- carbon black trade name “Vulcan XC72”, manufactured by CABOT Co., Ltd.
- Examples 5-1 to 5-9 3-hydroxytetrahydrofuran was produced in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 9.
- the results are shown in Table 10.
- “(0.25)” in the column of “Pd / W molar ratio” in Example 5-9 in Table 9 indicates the amount of Pd supported on the carrier in the catalyst used (1.4 wt% Pd / C). Means the same amount of Pd supported on the support in the catalyst used in Example 5-5 (9.9 wt% WO x -Pd / C obtained in Example 2a).
- Example 34a [Production of catalyst (9.9 wt% WO x -Pd / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 0.2818 g of an aqueous palladium (II) nitrate solution (Pd: 5.07%, manufactured by NV Chemcat) was diluted with 5 mL of distilled water was prepared.
- II aqueous palladium
- the total amount of the above ammonium tungstate aqueous solution is added in 5 portions to 0.8870 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT) so that the liquid does not accumulate, and heated and stirred at 70 to 90 ° C. And impregnated. After drying this at 110 ° C. overnight in a dryer, add the entire amount of the above diluted aqueous solution of palladium (II) in two portions so that the liquid does not accumulate, and heat and stir at 70 to 90 ° C. Impregnated. After impregnation, it was dried overnight at 110 ° C. in a dryer.
- the total amount of the product obtained above was filled into a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 300 ° C.
- the reduction treatment was carried out while maintaining the same temperature for 30 minutes. Thereafter, the mixture was cooled to room temperature over 30 minutes, and then hydrogen was switched to 2% oxygen (balanced He) gas to perform passivation for 2 hours to obtain a catalyst (9.9 wt% WO x -Pd / C).
- Example 35a [Production of catalyst (9.9 wt% WO x -Pd / C)] 0.1402 g of ammonium tungstate (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 15 mL of distilled water at 70 to 90 ° C. to prepare an aqueous solution. Further, an aqueous solution in which 0.2818 g of an aqueous palladium (II) nitrate solution (Pd: 5.07%, manufactured by NV Chemcat) was diluted with 5 mL of distilled water was prepared.
- II aqueous palladium
- the total amount of the above ammonium tungstate aqueous solution is added in 5 portions to 0.8870 g of carbon black (trade name “Vulcan XC72”, manufactured by CABOT) so that the liquid does not accumulate, and heated and stirred at 70 to 90 ° C. And impregnated. After drying this at 110 ° C. overnight in a dryer, add the entire amount of the above diluted aqueous solution of palladium (II) in two portions so that the liquid does not accumulate, and heat and stir at 70 to 90 ° C. Impregnated. After impregnation, it was dried overnight at 110 ° C. in a dryer.
- the total amount of the product obtained above was filled in a flow-through catalytic reduction device having an inner diameter of 0.6 cm, heated at a rate of 10 ° C./min while flowing hydrogen at 30 cc / min, and reached 500 ° C.
- the reduction treatment was carried out while maintaining the same temperature for 30 minutes. Thereafter, the mixture was cooled to room temperature over 30 minutes, and then hydrogen was switched to 2% oxygen (balanced He) gas to perform passivation for 2 hours to obtain a catalyst (9.9 wt% WO x -Pd / C).
- Examples 6-1 to 6-3 3-hydroxytetrahydrofuran was produced in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 11. The results are shown in Table 12.
- Examples 7-1 to 7-4 The production of 3-hydroxytetrahydrofuran was carried out in the same manner as in Example 1-1 except that the catalyst used was changed to the one shown in Table 13 and the amount of the catalyst used was changed as shown in Table 13. The results are shown in Table 14.
- Examples 8-1 to 8-4 The catalyst used was changed to that shown in Table 15, and the same procedure as in Example 1-1 was performed except that the amount of zeolite (H-ZSM-5) shown in Table 15 coexisted in the reaction system. Production of hydroxytetrahydrofuran was carried out. The results are shown in Table 16.
- Examples 9-1 to 9-6 The production of 3-hydroxytetrahydrofuran was carried out in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 17 and the reaction temperature and reaction time were changed as shown in Table 17. The results are shown in Table 18.
- Examples 10-1 to 10-6 The catalyst used was changed to that shown in Table 19, the reaction time was changed as shown in Table 19, and the amount of 1,4-dioxane used (ie, the concentration of 1,4-anhydroerythritol) was changed to Table 19.
- the production of 3-hydroxytetrahydrofuran was carried out in the same manner as in Example 1-1 except for the changes as shown. The results are shown in Table 20.
- Examples 11-1 to 11-3 The catalyst used was changed to the one shown in Table 21, the amount of 1,4-dioxane used was changed to 1 g, and the reaction time and hydrogen pressure were changed as shown in Table 21. Similarly, production of 3-hydroxytetrahydrofuran was carried out. The results are shown in Table 22.
- Examples 12-1 to 12-4 The production of 3-hydroxytetrahydrofuran was carried out in the same manner as in Example 1-1 except that the catalyst used was changed to that shown in Table 23 and the reaction time was changed as shown in Table 23. The results are shown in Table 24.
- Example 13-1 In the same manner as in Example 1-2, 3-hydroxytetrahydrofuran was produced. The results are shown in Table 26.
- Example 36a [Preparation of catalyst (4 wt% Ir—ReO x / SiO 2 )] Silicon dioxide (SiO 2 ) (trade name “G-6”, manufactured by Fuji Silysia Chemical Ltd., specific surface area: 535 m 2 / g) was used as a catalyst support.
- SiO 2 Silicon dioxide
- an aqueous solution of chloroiridate (H 2 IrCl 6 ) prepared so that the iridium (Ir) concentration is 4.47% by weight is added dropwise to wet the entire carrier, and then the carrier is cooled to 110 ° C. And dried for 3 hours.
- Example 14-1 [Production of 1,3-butanediol]
- a stirrer chip, 150 mg of the catalyst (4 wt% Ir—ReO x / SiO 2 ) obtained in Example 36a, and 4 g of water were placed in a glass autoclave inner cylinder.
- the autoclave inner cylinder was placed in an autoclave and covered.
- the operation of filling and exhausting 1 MPa of hydrogen into the autoclave was repeated three times to expel the air inside the autoclave.
- the autoclave was charged with hydrogen so that it showed 8 MPa at 200 ° C., which is the temperature during reduction, and 5 MPa at room temperature.
- the autoclave was set in a magnetic stirrer heating apparatus, and maintained for 1 hour while heating so that the temperature inside the reactor (inside the autoclave) became 200 ° C., thereby reducing the catalyst. Thereafter, the autoclave was once cooled to room temperature, hydrogen was released, and 1 g of 3-hydroxytetrahydrofuran was introduced. Then, the operation of filling and exhausting 1 MPa of hydrogen into the autoclave again was repeated three times to expel the air inside the autoclave. Thereafter, hydrogen was charged into the autoclave so as to show 1 MPa at room temperature, and subsequently heated to 100 ° C. When hydrogen reached 100 ° C., hydrogen was introduced so as to show 8 MPa and held for 6 hours. Thereafter, the mixture was cooled to room temperature, and the internal hydrogen was released and released.
- Examples 14-2 to 14-4 Production of 1,3-propanediol and analysis of the product were carried out in the same manner as in Example 14-1, except that the reaction time was changed as shown in Table 27. The results are shown in Table 27.
- Production Example 1 [Production of 1,4-anhydroerythritol: dehydration reaction step] In an autoclave, 1 g of erythritol, 4 g of water, and 0.15 g of a trade name “Amberlyst 70” as a catalyst were added and reacted under conditions of an argon pressure of 5 MPa and 160 ° C. for 24 hours to obtain 1,4-anhydroerythritol. . The conversion of erythritol was 98.6%, and the selectivity for 1,4-anhydroerythritol was 97.2%.
- THF Tetrahydrofuran 3-HTHF: 3-hydroxytetrahydrofuran 1,4-BuD: 1,4-butanediol 1,2,3-BuT: 1,2,3-butanetriol 1,3-BuD: 1,3-butane Diol 1,2-BuD: 1,2-butanediol 2,3-BuD: 2,3-butanediol 1-BuOH: 1-butanol 2-BuOH: 2-butanol 1,4-AHTRE: 1,4-an Hydroerythritol Others: Other compounds
- the method for producing 3-hydroxytetrahydrofuran of the present invention is a method for producing 3-hydroxytetrahydrofuran from 1,4-anhydroerythritol, which can be easily derived from biomass, erythritol.
- the method for producing 1,3-butanediol according to the present invention is a method for producing 1,3-butanediol using such 3-hydroxytetrahydrofuran as a raw material. 1,3-butanediol obtained by these methods is blended as a moisturizing agent for cosmetics, detergents, shampoos and the like, and is also expected to be used as a raw material for pharmaceuticals, food additives, various solvents and the like.
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Abstract
Description
また、本発明の他の目的は、3-ヒドロキシテトラヒドロフランを原料として、1,3-ブタンジオールを製造する方法を提供することにある。
(1)1,4-アンヒドロエリスリトールと水素との反応により、3-ヒドロキシテトラヒドロフランを生成させる工程を含むことを特徴とする3-ヒドロキシテトラヒドロフランの製造方法。
(2)前記工程における1,4-アンヒドロエリスリトールと水素との反応を、担体と、該担体に担持された第6族元素の酸化物及び第7族元素の酸化物からなる群より選択された少なくとも一種の酸化物とを含む触媒の存在下で進行させる(1)に記載の3-ヒドロキシテトラヒドロフランの製造方法。
(3)前記酸化物がタングステンの酸化物である(2)に記載の3-ヒドロキシテトラヒドロフランの製造方法。
(4)前記担体が、活性炭又は無機酸化物である(2)又は(3)に記載の3-ヒドロキシテトラヒドロフランの製造方法。
(5)前記担体の比表面積が50m2/g以上である(2)~(4)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(6)前記担体の平均粒径が100~10000μmである(2)~(5)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(7)前記触媒における前記酸化物の担体への担持量(前記酸化物を構成する金属原子換算)が、前記酸化物と担体の総量(100重量%)に対して、0.01~50重量%である(2)~(6)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(8)前記触媒が、さらに、前記担体に担持された、第6族元素及び第7族元素以外の金属を含む(2)~(7)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(9)前記金属が、パラジウム、白金、鉄、コバルト、ニッケル、及び銅からなる群より選択された少なくとも一種の金属である(8)に記載の3-ヒドロキシテトラヒドロフランの製造方法。
(10)前記触媒における前記酸化物を構成する第6族元素及び第7族元素と、前記金属との割合(モル比、金属換算)[前記金属/第6族元素及び第7族元素]が、50/1~1/500である(8)又は(9)に記載の3-ヒドロキシテトラヒドロフランの製造方法。
(11)前記無機酸化物が、チタニア、ジルコニア、マグネシア、シリカ、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である(4)~(10)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(12)前記触媒の平均粒径が100~10000μmである(2)~(11)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(13)前記1,4-アンヒドロエリスリトールと水素との反応を、固体酸の共存下で進行させる(1)~(12)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(14)前記固体酸の使用量が、1,4-アンヒドロエリスリトール100重量部に対して、0.1~50重量部である(13)に記載の3-ヒドロキシテトラヒドロフランの製造方法。
(15)前記反応に付す水素と1,4-アンヒドロエリスリトールのモル比[水素(mol)/1,4-アンヒドロエリスリトール(mol)]が1~100である(1)~(14)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(16)前記反応における1,4-アンヒドロエリスリトールと水素の反応温度が50~250℃である(1)~(15)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(17)前記反応における1,4-アンヒドロエリスリトールと水素の反応時間が0.1~100時間である(1)~(16)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(18)前記反応における1,4-アンヒドロエリスリトールと水素の反応圧力(1,4-アンヒドロエリスリトールと水素の反応における水素圧)が1~50MPaである(1)~(17)のいずれか1つに記載の3-ヒドロキシテトラヒドロフランの製造方法。
(19)1,4-アンヒドロエリスリトールと水素との反応により3-ヒドロキシテトラヒドロフランを生成させる反応に用いられる1,4-アンヒドロエリスリトールの水素化反応用触媒であって、担体と、該担体に担持された第6族元素の酸化物及び第7族元素の酸化物からなる群より選択された少なくとも一種の酸化物とを含むことを特徴とする水素化反応用触媒。
(20)前記酸化物がタングステンの酸化物である(19)に記載の水素化反応用触媒。
(21)前記担体が、活性炭又無機酸化物である(19)又は(20)に記載の水素化反応用触媒。
(22)前記担体の比表面積が50m2/g以上である(19)~(21)のいずれか1つに記載の水素化反応用触媒。
(23)前記担体の平均粒径が100~10000μmである(19)~(22)のいずれか1つに記載の水素化反応用触媒。
(24)前記酸化物の担体への担持量(前記酸化物を構成する金属原子換算)が、前記酸化物と担体の総量(100重量%)に対して、0.01~50重量%である(19)~(23)のいずれか1つに記載の水素化反応用触媒。
(25)さらに、前記担体に担持された、第6族元素及び第7族元素以外の金属を含む(19)~(24)のいずれか1つに記載の水素化反応用触媒。
(26)前記金属が、パラジウム、白金、鉄、コバルト、ニッケル、及び銅からなる群より選択された少なくとも一種の金属である(25)に記載の水素化反応用触媒。
(27)前記酸化物を構成する第6族元素及び第7族元素と、前記金属との割合(モル比、金属換算)[前記金属/第6族元素及び第7族元素]が、50/1~1/500である(25)又は(26)に記載の水素化反応用触媒。
(28)前記無機酸化物が、チタニア、ジルコニア、マグネシア、シリカ、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である(21)~(27)のいずれか1つに記載の水素化反応用触媒。
(29)平均粒径が100~10000μmである(19)~(28)のいずれか1つに記載の水素化反応用触媒。
(30)3-ヒドロキシテトラヒドロフランと水素との反応により、1,3-ブタンジオールを生成させる工程を含むことを特徴とする1,3-ブタンジオールの製造方法。
(31)前記工程における3-ヒドロキシテトラヒドロフランと水素との反応を、担体と、該担体に担持されたイリジウム、レニウム、ルテニウム、モリブデン、及びタングステンからなる群より選択された少なくとも一種の金属とを含む触媒の存在下で進行させる(30)に記載の1,3-ブタンジオールの製造方法。
(32)前記触媒が、前記金属としてイリジウム及びレニウムを含む(31)に記載の1,3-ブタンジオールの製造方法。
(33)前記担体が無機酸化物である(31)又は(32)に記載の1,3-ブタンジオールの製造方法。
(34)前記無機酸化物が、シリカ、マグネシア、チタニア、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である(33)に記載の1,3-ブタンジオールの製造方法。
(35)前記担体の比表面積が50m2/g以上である(31)~(34)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(36)前記担体の平均粒径が100~10000μmである(31)~(35)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(37)前記触媒における、イリジウム、レニウム、ルテニウム、モリブデン、及びタングステンからなる群より選択された少なくとも一種の金属の担体への担持量(総量)(金属原子換算)が、前記金属と担体の総量(100重量%)に対して、0.01~50重量%である(31)~(36)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(38)前記触媒におけるイリジウムとレニウムの割合(モル比、金属換算)[イリジウム/レニウム]が50/1~1/6である(31)~(37)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(39)前記触媒の平均粒径が100~10000μmである(31)~(38)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(40)前記3-ヒドロキシテトラヒドロフランが、1,4-アンヒドロエリスリトールと水素との反応により製造された3-ヒドロキシテトラヒドロフランである(30)~(39)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(41)前記反応に付す水素と3-ヒドロキシテトラヒドロフランのモル比[水素(mol)/3-ヒドロキシテトラヒドロフラン(mol)]が1~100である(30)~(40)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(42)前記反応における3-ヒドロキシテトラヒドロフランと水素の反応温度が50~200℃である(30)~(41)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(43)前記反応における3-ヒドロキシテトラヒドロフランと水素との反応時間が0.1~100時間である(30)~(42)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(44)前記反応における3-ヒドロキシテトラヒドロフランと水素の反応圧力(3-ヒドロキシテトラヒドロフランと水素の反応における水素圧)が1~50MPaである(30)~(43)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(45)前記工程の前に、1,4-アンヒドロエリスリトールと水素との反応により3-ヒドロキシテトラヒドロフランを生成させる工程を含む(30)~(44)のいずれか1つに記載の1,3-ブタンジオールの製造方法。
(46)3-ヒドロキシテトラヒドロフランと水素との反応により1,3-ブタンジオールを生成させる反応に用いられる3-ヒドロキシテトラヒドロフランの水素化反応用触媒であって、担体と、該担体に担持されたイリジウム、レニウム、ルテニウム、モリブデン、及びタングステンからなる群より選択された少なくとも一種の金属とを含むことを特徴とする水素化反応用触媒。
(47)前記金属としてイリジウム及びレニウムを含む(46)に記載の水素化反応用触媒。
(48)前記担体が無機酸化物である(46)又は(47)に記載の水素化反応用触媒。
(49)前記無機酸化物が、シリカ、マグネシア、チタニア、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である(48)に記載の水素化反応用触媒。
(50)前記担体の比表面積が50m2/g以上である(46)~(49)のいずれか1つに記載の水素化反応用触媒。
(51)前記担体の平均粒径が100~10000μmである(46)~(50)のいずれか1つに記載の水素化反応用触媒。
(52)イリジウム、レニウム、ルテニウム、モリブデン、及びタングステンからなる群より選択された少なくとも一種の金属の担体への担持量(総量)(金属原子換算)が、前記金属と担体の総量(100重量%)に対して、0.01~50重量%である(46)~(51)のいずれか1つに記載の水素化反応用触媒。
(53)イリジウムとレニウムの割合(モル比、金属換算)[イリジウム/レニウム]が50/1~1/6である(46)~(52)のいずれか1つに記載の水素化反応用触媒。
(54)平均粒径が100~10000μmである(46)~(53)のいずれか1つに記載の水素化反応用触媒。
同様に、本発明の1,3-ブタンジオールの製造方法は、バイオマスであるエリスリトールを出発原料として誘導可能な3-ヒドロキシテトラヒドロフランを原料として1,3-ブタンジオールを生成させる方法であるため、環境に与える負荷が小さく、持続可能な社会の構築に大きく寄与するものである。また、上記製造方法によると、1,3-ブタンジオールを高い選択率で生成させることができるため、コスト面でも有利である。
本発明の3-ヒドロキシテトラヒドロフランの製造方法は、1,4-アンヒドロエリスリトールと水素との反応により、3-ヒドロキシテトラヒドロフランを生成させる工程(「水素化反応工程A」と称する場合がある)を必須の工程として含むことを特徴としている。
上記水素化反応工程Aにおいて原料として使用される1,4-アンヒドロエリスリトール(3,4-ジヒドロキシオキソラン)は、下記式(1)で表される化合物である。1,4-アンヒドロエリスリトールは、式(1)に示されるように、エリスリトールの1位と4位の水酸基が脱水縮合して形成された構造を有する化合物である。
上記水素化反応工程Aにおいて使用される水素(水素ガス)は、実質的に水素のみの状態で使用することもできるし、窒素、アルゴン、ヘリウム等の不活性ガス等により希釈した状態で使用することもできる。また、上記水素化反応工程Aを経た結果得られる反応混合物から回収した水素(未反応の水素)を再利用することもできる。
上記水素化反応工程Aにおける1,4-アンヒドロエリスリトールと水素との反応は、触媒(1,4-アンヒドロエリスリトールと水素との反応により3-ヒドロキシテトラヒドロフランを生成させる反応に用いられる、1,4-アンヒドロエリスリトールの水素化反応用触媒)の存在下で進行させることが好ましい。触媒を使用することにより上記反応が促進され、1,4-アンヒドロエリスリトールの転化率が向上し、3-ヒドロキシテトラヒドロフランの選択率が向上する傾向がある。
本発明の3-ヒドロキシテトラヒドロフランの製造方法における水素化反応工程Aは、好ましくは本発明の触媒(1)の存在下、1,4-アンヒドロエリスリトールと水素との反応により1,3-ヒドロキシテトラヒドロフランを生成させる工程である。上記1,4-アンヒドロエリスリトールと水素との反応は、本発明の触媒(1)(固体)の存在下、気体状の(気化させた)1,4-アンヒドロエリスリトールと水素とを反応させる気固二相系の反応であってもよいし、本発明の触媒(1)(固体)の存在下、液状の1,4-アンヒドロエリスリトールと水素とを反応させる気液固三相系の反応であってもよい。特に、炭素-炭素結合の開裂による炭素数が3以下の化合物の生成を抑制する観点からは、上記反応を気液固三相系で進行させることが好ましい。
上記脱水反応工程におけるエリスリトールの分子内脱水反応は、周知の方法により実施することができ、特に限定されないが、例えば、酸触媒の存在下でエリスリトールを加熱することにより進行させることができる。なお、上記脱水反応工程は、上記水素化反応工程Aとは別ラインで実施してもよいし、上記水素化反応工程Aと一連の工程として実施してもよい。
本発明の1,3-ブタンジオールの製造方法は、3-ヒドロキシテトラヒドロフランと水素との反応により、1,3-ブタンジオールを生成させる工程(「水素化反応工程B」と称する場合がある)を必須の工程として含むことを特徴としている。
上記水素化反応工程Bにおいて原料として使用される3-ヒドロキシテトラヒドロフランとしては、例えば、上述の本発明の3-ヒドロキシテトラヒドロフランの製造方法(水素化反応工程A、又は、脱水反応工程及び水素化反応工程Aを含む方法)により得られたものを使用することもできるし、その他の方法により得られたものを使用することもできる。中でも、前者の方法で得られた3-ヒドロキシテトラヒドロフラン(1,4-アンヒドロエリスリトールと水素との反応により製造された3-ヒドロキシテトラヒドロフラン)を使用することにより、環境負荷の低減に寄与することができる。
上記水素化反応工程Bにおいて使用される水素(水素ガス)は、実質的に水素のみの状態で使用することもできるし、窒素、アルゴン、ヘリウム等の不活性ガス等により希釈した状態で使用することもできる。また、上記水素化反応工程Bを経た結果得られる反応混合物から回収した水素(未反応の水素)を再利用することもできる。
上記水素化反応工程Bにおける3-ヒドロキシテトラヒドロフランと水素との反応は、触媒(3-ヒドロキシテトラヒドロフランと水素との反応により1,3-ブタンジオールを生成させる反応に用いられる、3-ヒドロキシテトラヒドロフランの水素化反応用触媒)の存在下で進行させることが好ましい。触媒を使用することにより上記反応が促進され、3-ヒドロキシテトラヒドロフランの転化率が向上し、1,3-ブタンジオールの選択率が向上する傾向がある。
本発明の1,3-ブタンジオールの製造方法における水素化反応工程Bは、好ましくは本発明の触媒(2)の存在下、3-ヒドロキシテトラヒドロフランと水素との反応により1,3-ブタンジオールを生成させる工程である。3-ヒドロキシテトラヒドロフランと水素との反応は、本発明の触媒(2)(固体)の存在下、気体状の(気化させた)1,3-ヒドロキシテトラヒドロフランと水素とを反応させる気固二相系の反応であってもよいし、本発明の触媒(2)(固体)の存在下、液状の3-ヒドロキシテトラヒドロフランと水素とを反応させる気液固三相系の反応であってもよい。特に、炭素-炭素結合の開裂による炭素数が3以下の化合物の生成を抑制する観点からは、上記反応を気液固三相系で進行させることが好ましい。
[触媒(9.9wt%WOX/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.9013gに、液だまりができないように上記水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX/C)を得た。
[触媒(9.9wt%WOX-Pd/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸パラジウム(II)水溶液(Pd:5.07%、エヌ・イーケムキャット社製)0.2818gを、蒸留水5mLで希釈した水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8870gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸パラジウム(II)の希釈水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させて、触媒(9.9wt%WOX-Pd/C)を得た。
[触媒(9.9wt%WOX-Pt/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、ビス(アセチルアセトナト)白金0.0528gを、アセトン5mLに溶解させた溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8751gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記ビス(アセチルアセトナト)白金の溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させて、触媒(9.9wt%WOX-Pt/C)を得た。
[触媒(9.9wt%WOX-Fe/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸鉄(III)九水和物0.0542gを、水5mLに溶解させた水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8938gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸鉄(III)水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Fe/C)を得た。
[触媒(9.9wt%WOX-Co/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸コバルト(II)六水和物0.0391gを、水5mLに溶解させた水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8938gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸コバルト(II)水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Co/C)を得た。
[触媒(9.9wt%WOX-Ni/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸ニッケル(II)六水和物0.0391gを、水5mLに溶解させた水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8934gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸ニッケル(II)水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Ni/C)を得た。
[触媒(9.9wt%WOX-Cu/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸銅(II)三水和物0.0324gを、水5mLに溶解させた水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8927gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸銅(II)水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Cu/C)を得た。
[3-ヒドロキシテトラヒドロフランの製造]
ガラス製のオートクレーブ用内筒にスターラーチップと、秤量した実施例1aで得られた触媒(9.9wt%WOX/C)150mgと、1,4-ジオキサン4gと、1,4-アンヒドロエリスリトール1gとを入れた。上記オートクレーブ用内筒を190mLオートクレーブに入れ、蓋をした。次いで、オートクレーブの内部に1MPaの水素を張り込んだ後に排気する操作を3回繰り返し、内部の空気をオートクレーブから追い出した。このオートクレーブに、水素を反応温度である180℃で8MPaを示すよう、室温で5MPaを示すように充填した。
続いて、上記オートクレーブをマグネットスターラー付加熱装置にセットし、反応器内部(オートクレーブ内部)の温度が180℃になるように加熱しながら、16時間加熱した。その後、室温まで冷却し、オートクレーブ内部の水素を解放し、放圧した。
反応後の溶液は、ガスクロマトグラフィー(ガスクロマトグラフ装置:「GC-2014」((株)島津製作所製)、GCカラム:TC-WAX、DB-FFAP、検出器:FID)を用いて分析した。これより、1,4-アンヒドロエリスリトールの転化率、生成物の選択率を算出した。分析結果を表2に示す。
使用した触媒を表1に示すものに変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表2に示す。なお、表1の「還元処理」の欄に記載の温度は触媒製造時の還元処理の温度を示す。表1の「還元処理」の欄における「None」は、触媒製造時に還元処理を行わなかったことを意味し、以下の実施例においても同様である。また、表1の「M/W」は、担体に担持されたタングステン(W)と、タングステン以外の金属(M)の割合(モル比)を意味する。
[触媒(9.9wt%WOX/C BP2000)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「BP2000」(カーボンブラック、CABOT社製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/C)を得た。
[触媒(9.9wt%WOX/C Shirasagi FAC-10)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「Shirasagi FAC-10」(カーボンブラック、日本エンバイロケミカルズ(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/C)を得た。
[触媒(9.9wt%WOX/C Shirasagi M)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「Shirasagi M」(カーボンブラック、日本エンバイロケミカルズ(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/C)を得た。
[触媒(9.9wt%WOX/C Shirasagi C)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「Shirasagi C」(カーボンブラック、日本エンバイロケミカルズ(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/C)を得た。
[触媒(9.9wt%WOX/C Carboraffin)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「Carboraffin」(カーボンブラック、日本エンバイロケミカルズ(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/C)を得た。
[触媒(9.9wt%WOX/TiO2)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「TIO-4」(チタニア、日本アエロジル(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/TiO2)を得た。
[触媒(9.9wt%WOX/ZrO2)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、ジルコニア(和光純薬工業(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/ZrO2)を得た。
[触媒(9.9wt%WOX/MgO)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「500A」(マグネシア、宇部興産(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/MgO)を得た。
[触媒(9.9wt%WOX/SiO2)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「G-6」(シリカ、富士シリシア化学(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/SiO2)を得た。
[触媒(9.9wt%WOX/Al2O3)の製造]
商品名「Vulcan XC72」(カーボンブラック、CABOT社製)の代わりに、商品名「KHO-24」(アルミナ、住友化学(株)製)0.9013gを使用したこと以外は実施例1aと同様にして、触媒(9.9wt%WOX/Al2O3)を得た。
使用した触媒を表3に示すものに変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表4に示す。
[触媒(9.9wt%WOX-Pd/C)の製造]
硝酸パラジウム(II)水溶液(Pd:5.07%、エヌ・イーケムキャット社製)の使用量を4.0588gとしたこと以外は実施例2aと同様にして、触媒(9.9wt%WOX-Pd/C;W/Pd=0.25)を得た。
[触媒(9.9wt%WOX-Pd/TiO2)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸パラジウム(II)水溶液(Pd:5.07%、エヌ・イーケムキャット社製)4.0588gを、蒸留水5mLで希釈した水溶液を作製した。次いで、商品名「TIO-4」(チタニア、日本アエロジル(株)製)0.9013gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸パラジウム(II)の希釈水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させて、触媒(9.9wt%WOX-Pd/TiO2;W/Pd=0.25)を得た。
[触媒(9.9wt%WOX-Pd/Al2O3)の製造]
商品名「TIO-4」(チタニア、日本アエロジル(株)製)の代わりに、商品名「KHO-24」(アルミナ、住友化学(株)製)0.9013gを使用したこと以外は実施例19aと同様にして、触媒(9.9wt%WOX-Pd/Al2O3;W/Pd=0.25)を得た。
[触媒(9.9wt%WOX-Pd/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸パラジウム(II)水溶液(Pd:5.07%、エヌ・イーケムキャット社製)4.0588gを、蒸留水5mLで希釈した水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8870gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸パラジウム(II)の希釈水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Pd/C;W/Pd=0.25)を得た。
[触媒(9.9wt%WOX-Pd/TiO2)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸パラジウム(II)水溶液(Pd:5.07%、エヌ・イーケムキャット社製)4.0588gを、蒸留水5mLで希釈した水溶液を作製した。次いで、商品名「TIO-4」(チタニア、日本アエロジル(株)製)0.9013gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸パラジウム(II)の希釈水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Pd/TiO2;W/Pd=0.25)を得た。
[触媒(9.9wt%WOX-Pd/Al2O3)の製造]
商品名「TIO-4」(チタニア、日本アエロジル(株)製)の代わりに、商品名「KHO-24」(アルミナ、住友化学(株)製)0.9013gを使用したこと以外は実施例22aと同様にして、触媒(9.9wt%WOX-Pd/Al2O3;W/Pd=0.25)を得た。
使用した触媒を表5に示すものに変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表6に示す。なお、表5の「W/Pd」は、担体に担持されたタングステン(W)と、パラジウム(Pd)の割合(モル比)を意味する。
[触媒(3.3wt%WOX-Pd/C)の製造]
タングステン酸アンモニウムの使用量を0.0467gに変更し、硝酸パラジウム(II)水溶液の使用量を0.0939gに変更したこと以外は実施例2aと同様にして、触媒(3.3wt%WOX-Pd/C)を得た。
[触媒(6.6wt%WOX-Pd/C)の製造]
タングステン酸アンモニウムの使用量を0.0935gに変更し、硝酸パラジウム(II)水溶液の使用量を0.1879gに変更したこと以外は実施例2aと同様にして、触媒(6.6wt%WOX-Pd/C)を得た。
[触媒(13.2wt%WOX-Pd/C)の製造]
タングステン酸アンモニウムの使用量を0.1869gに変更し、硝酸パラジウム(II)水溶液の使用量を2.1879gに変更したこと以外は実施例2aと同様にして、触媒(13.2wt%WOX-Pd/C)を得た。
使用した触媒を表7に示すものに変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表8に示す。なお、表7の「Pd/W」は、担体に担持されたタングステン(W)と、パラジウム(Pd)の割合(モル比)を意味し、以下も同様である。
[触媒(9.9wt%WOX-Pd/C;Pd/W=0.032)の製造]
硝酸パラジウム(II)水溶液の使用量を0.0352gに変更したこと以外は実施例2aと同様にして、触媒(9.9wt%WOX-Pd/C;Pd/W=0.032)を得た。
[触媒(9.9wt%WOX-Pd/C、Pd/W=0.063)の製造]
硝酸パラジウム(II)水溶液の使用量を0.0705gに変更したこと以外は実施例2aと同様にして、触媒(9.9wt%WOX-Pd/C、Pd/W=0.063)を得た。
[触媒(9.9wt%WOX-Pd/C、Pd/W=0.13)の製造]
硝酸パラジウム(II)水溶液の使用量を0.1409gに変更したこと以外は実施例2aと同様にして、触媒(9.9wt%WOX-Pd/C、Pd/W=0.13)を得た。
[触媒(9.9wt%WOX-Pd/C、Pd/W=0.5)の製造]
硝酸パラジウム(II)水溶液の使用量を0.5636gに変更したこと以外は実施例2aと同様にして、触媒(9.9wt%WOX-Pd/C、Pd/W=0.5)を得た。
[触媒(9.9wt%WOX-Pd/C、Pd/W=1)の製造]
硝酸パラジウム(II)水溶液の使用量を1.1272gに変更したこと以外は実施例2aと同様にして、触媒(9.9wt%WOX-Pd/C、Pd/W=1)を得た。
[触媒(9.9wt%WOX-Pd/C、Pd/W=2)の製造]
硝酸パラジウム(II)水溶液の使用量を2.2544gに変更したこと以外は実施例2aと同様にして、触媒(9.9wt%WOX-Pd/C、Pd/W=2)を得た。
[触媒(1.4wt%Pd/C)の製造]
硝酸パラジウム(II)水溶液(Pd:5.07%)0.2818gを蒸留水5mLで希釈し、水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.9857gに液だまりができないように上記水溶液を3回に分けて全量を加え、70~90℃で加熱及び攪拌して含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させて触媒(1.4wt%Pd/C)を得た。
使用した触媒を表9に示すものに変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表10に示す。なお、表9の実施例5-9における「Pd/Wモル比」の欄の「(0.25)」は、使用した触媒(1.4wt%Pd/C)におけるPdの担体への担持量が実施例5-5で使用した触媒(実施例2aで得られた9.9wt%WOX-Pd/C)におけるPdの担体への担持量と同量であることを意味する。
[触媒(9.9wt%WOX-Pd/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸パラジウム(II)水溶液(Pd:5.07%、エヌ・イーケムキャット社製)0.2818gを、蒸留水5mLで希釈した水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8870gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸パラジウム(II)の希釈水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、300℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Pd/C)を得た。
[触媒(9.9wt%WOX-Pd/C)の製造]
タングステン酸アンモニウム(和光純薬工業(株)製)0.1402gを、70~90℃の蒸留水15mLに溶解させ、水溶液を作製した。また、硝酸パラジウム(II)水溶液(Pd:5.07%、エヌ・イーケムキャット社製)0.2818gを、蒸留水5mLで希釈した水溶液を作製した。次いで、カーボンブラック(商品名「Vulcan XC72」、CABOT社製)0.8870gに、液だまりができないように上記タングステン酸アンモニウム水溶液を5回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。これを乾燥機内にて110℃で一晩乾燥させた後、液だまりができないように上記硝酸パラジウム(II)の希釈水溶液を2回に分けて全量加え、70~90℃で加熱及び攪拌して、含浸させた。含浸させた後、乾燥機内にて110℃で一晩乾燥させた。
次いで、上記で得たものの全量を内径0.6cmの流通型触媒還元装置に充填し、30cc/分で水素を流通させながら10℃/分の速度で昇温させ、500℃に到達した後、30分間同温度で維持し、還元処理を実施した。
その後、30分かけて室温まで冷却し、次いで、水素を2%酸素(バランスHe)ガスに切り替えて、2時間パッシベーションを実施し、触媒(9.9wt%WOX-Pd/C)を得た。
使用した触媒を表11に示すものに変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表12に示す。
使用した触媒を表13に示すものに変更し、触媒の使用量を表13に示すように変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表14に示す。
使用した触媒を表15に示すものに変更し、反応系中に表15に示す量のゼオライト(H-ZSM-5)を共存させたこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表16に示す。
使用した触媒を表17に示すものに変更し、反応温度及び反応時間を表17に示すように変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表18に示す。
使用した触媒を表19に示すものに変更し、反応時間を表19に示すように変更し、1,4-ジオキサンの使用量(即ち、1,4-アンヒドロエリスリトールの濃度)を表19に示すように変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表20に示す。
使用した触媒を表21に示すものに変更し、1,4-ジオキサンの使用量を1gに変更し、反応時間及び水素圧を表21に示すように変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表22に示す。
使用した触媒を表23に示すものに変更し、反応時間を表23に示すように変更したこと以外は実施例1-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表24に示す。
実施例1-2と同様に3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表26に示す。
使用した触媒を表25に示すものに変更し、1,4-アンヒドロエリスリトールの代わりに表25に示す反応基質を使用したこと以外は実施例13-1と同様にして、3-ヒドロキシテトラヒドロフランの製造を実施した。結果を表26に示す。
[触媒(4wt%Ir-ReOX/SiO2)の調製]
二酸化ケイ素(SiO2)(商品名「G-6」、富士シリシア化学(株)製、比表面積:535m2/g)を触媒の担体として使用した。上記担体に、イリジウム(Ir)濃度が4.47重量%となるように調製した塩化イリジウム酸(H2IrCl6)水溶液を滴下して、上記担体全体を湿潤させた後、該担体を110℃で3時間乾燥させた。そして、このような塩化イリジウム酸水溶液の滴下と乾燥を繰り返して、イリジウムの量がSiO2に対して4重量%となるように担持させた。
次に、上記担体(イリジウムを担持させた担体)に、レニウム(Re)濃度が3重量%となるように調製した過レニウム酸アンモニウム(NH4ReO4)水溶液の滴下と乾燥を、先の塩化イリジウム酸水溶液の滴下と乾燥と同様に繰り返して、レニウムとイリジウムのモル比[Re/Ir]が2/1となるようにレニウムを担持させた。その後、乾燥後の担体を、空気雰囲気下(大気中)、500℃、3時間の条件で焼成して、触媒(4wt%Ir-ReOX/SiO2)を調製した。
[1,3-ブタンジオールの製造]
ガラス製のオートクレーブ用内筒にスターラーチップと、実施例36aで得られた触媒(4wt%Ir-ReOX/SiO2)150mgと、水4gとを入れた。上記オートクレーブ用内筒をオートクレーブに入れ、蓋をした。次いで、オートクレーブ内部に1MPaの水素を張り込んで排気する操作を3回繰り返し、内部の空気をオートクレーブから追い出した。このオートクレーブに水素を、還元する際の温度である200℃で8MPaを示すよう、室温で5MPaを示すように充填した。
続いて、上記オートクレーブをマグネットスターラー付加熱装置にセットし、反応器内部(オートクレーブ内部)の温度が200℃になるように加熱しながら1時間保持し、触媒を還元した。
その後、一度オートクレーブを室温まで冷却し、水素を解放して3-ヒドロキシテトラヒドロフラン1gを導入した。そして、再びオートクレーブ内部に1MPaの水素を張り込んで排気する操作を3回繰り返して、内部の空気をオートクレーブから追い出した。その後、上記オートクレーブに水素を室温において1MPaを示すように充填し、続いて100℃まで加熱し、100℃に達したところで8MPaを示すように水素を導入し、6時間保持した。
その後、室温まで冷却し、内部の水素を解放して放圧した。
反応終了後の溶液につき、ガスクロマトグラフィー(ガスクロマトグラフ装置:「GC-2014」((株)島津製作所製)、GCカラム:TC-WAX、DB-FFAP、検出器:FID)により生成物の定量分析を行い、3-ヒドロキシテトラヒドロフランの転化率、テトラヒドロフラン、1,4-ブタンジオール、1,2,3-ブタントリオール、1,2-ブタンジオール、2,3-ブタンジオール、1-ブタノール、2-ブタノール、1,4-アンヒドロエリスリトール、及びその他の生成物の選択率を算出した。結果を表27に示す。なお、生成物の同定は、GC-MS(「QP5050」、(株)島津製作所製)により行った。
反応時間を表27に示すように変更したこと以外は実施例14-1と同様にして、1,3-プロパンジオールの製造及び生成物の分析を実施した。結果を表27に示す。
[1,4-アンヒドロエリスリトールの製造:脱水反応工程]
オートクレーブ中にエリスリトール1g、水4g、及び触媒として商品名「Amberlyst70」0.15gを加え、アルゴン圧5MPa、160℃、24時間の条件で反応させたところ、1,4-アンヒドロエリスリトールを得た。エリスリトールの転化率は98.6%であり、1,4-アンヒドロエリスリトールの選択率は97.2%であった。
THF : テトラヒドロフラン
3-HTHF : 3-ヒドロキシテトラヒドロフラン
1,4-BuD : 1,4-ブタンジオール
1,2,3-BuT : 1,2,3-ブタントリオール
1,3-BuD : 1,3-ブタンジオール
1,2-BuD : 1,2-ブタンジオール
2,3-BuD : 2,3-ブタンジオール
1-BuOH : 1-ブタノール
2-BuOH : 2-ブタノール
1,4-AHTRE : 1,4-アンヒドロエリスリトール
Others : その他の化合物
2:原料液供給ライン
3:水素供給ライン
4:反応混合物取り出しライン
5:高圧気液分離器
6:水素リサイクルライン
Claims (20)
- 1,4-アンヒドロエリスリトールと水素との反応により、3-ヒドロキシテトラヒドロフランを生成させる工程を含むことを特徴とする3-ヒドロキシテトラヒドロフランの製造方法。
- 前記工程における1,4-アンヒドロエリスリトールと水素との反応を、担体と、該担体に担持された第6族元素の酸化物及び第7族元素の酸化物からなる群より選択された少なくとも一種の酸化物とを含む触媒の存在下で進行させる請求項1に記載の3-ヒドロキシテトラヒドロフランの製造方法。
- 前記担体が、活性炭又は無機酸化物である請求項2に記載の3-ヒドロキシテトラヒドロフランの製造方法。
- 前記触媒が、さらに、前記担体に担持された、第6族元素及び第7族元素以外の金属を含む請求項2又は3に記載の3-ヒドロキシテトラヒドロフランの製造方法。
- 前記金属が、パラジウム、白金、鉄、コバルト、ニッケル、及び銅からなる群より選択された少なくとも一種の金属である請求項4に記載の3-ヒドロキシテトラヒドロフランの製造方法。
- 前記無機酸化物が、チタニア、ジルコニア、マグネシア、シリカ、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である請求項3~5のいずれか1項に記載の3-ヒドロキシテトラヒドロフランの製造方法。
- 1,4-アンヒドロエリスリトールと水素との反応により3-ヒドロキシテトラヒドロフランを生成させる反応に用いられる1,4-アンヒドロエリスリトールの水素化反応用触媒であって、担体と、該担体に担持された第6族元素の酸化物及び第7族元素の酸化物からなる群より選択された少なくとも一種の酸化物とを含むことを特徴とする水素化反応用触媒。
- 前記担体が、活性炭又無機酸化物である請求項7に記載の水素化反応用触媒。
- さらに、前記担体に担持された、第6族元素及び第7族元素以外の金属を含む請求項7又は8に記載の水素化反応用触媒。
- 前記金属が、パラジウム、白金、鉄、コバルト、ニッケル、及び銅からなる群より選択された少なくとも一種の金属である請求項9に記載の水素化反応用触媒。
- 前記無機酸化物が、チタニア、ジルコニア、マグネシア、シリカ、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である請求項8~10のいずれか1項に記載の水素化反応用触媒。
- 3-ヒドロキシテトラヒドロフランと水素との反応により、1,3-ブタンジオールを生成させる工程を含むことを特徴とする1,3-ブタンジオールの製造方法。
- 前記工程における3-ヒドロキシテトラヒドロフランと水素との反応を、担体と、該担体に担持されたイリジウム、レニウム、ルテニウム、モリブデン、及びタングステンからなる群より選択された少なくとも一種の金属とを含む触媒の存在下で進行させる請求項12に記載の1,3-ブタンジオールの製造方法。
- 前記担体が無機酸化物である請求項13に記載の1,3-ブタンジオールの製造方法。
- 前記無機酸化物が、シリカ、マグネシア、チタニア、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である請求項14に記載の1,3-ブタンジオールの製造方法。
- 前記3-ヒドロキシテトラヒドロフランが、1,4-アンヒドロエリスリトールと水素との反応により製造された3-ヒドロキシテトラヒドロフランである請求項12~15のいずれか1項に記載の1,3-ブタンジオールの製造方法。
- 前記工程の前に、1,4-アンヒドロエリスリトールと水素との反応により3-ヒドロキシテトラヒドロフランを生成させる工程を含む請求項12~16のいずれか1項に記載の1,3-ブタンジオールの製造方法。
- 3-ヒドロキシテトラヒドロフランと水素との反応により1,3-ブタンジオールを生成させる反応に用いられる3-ヒドロキシテトラヒドロフランの水素化反応用触媒であって、担体と、該担体に担持されたイリジウム、レニウム、ルテニウム、モリブデン、及びタングステンからなる群より選択された少なくとも一種の金属とを含むことを特徴とする水素化反応用触媒。
- 前記担体が無機酸化物である請求項18に記載の水素化反応用触媒。
- 前記無機酸化物が、シリカ、マグネシア、チタニア、及びアルミナからなる群より選択された少なくとも一種の無機酸化物である請求項19に記載の水素化反応用触媒。
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CN105624227A (zh) * | 2016-03-01 | 2016-06-01 | 苏州艾缇克药物化学有限公司 | 一种基于赤藓醇微生物制备(s)-3-羟基四氢呋喃的方法 |
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