WO2014061151A1 - Dispositif d'administration de médicament - Google Patents

Dispositif d'administration de médicament Download PDF

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Publication number
WO2014061151A1
WO2014061151A1 PCT/JP2012/077117 JP2012077117W WO2014061151A1 WO 2014061151 A1 WO2014061151 A1 WO 2014061151A1 JP 2012077117 W JP2012077117 W JP 2012077117W WO 2014061151 A1 WO2014061151 A1 WO 2014061151A1
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WO
WIPO (PCT)
Prior art keywords
syringe
holder
administration device
support
exterior member
Prior art date
Application number
PCT/JP2012/077117
Other languages
English (en)
Japanese (ja)
Inventor
小川　淳一
陽一郎 岩瀬
立川　浩一
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to PCT/JP2012/077117 priority Critical patent/WO2014061151A1/fr
Publication of WO2014061151A1 publication Critical patent/WO2014061151A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
    • A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston

Definitions

  • the present invention relates to a drug administration device for administering a drug to the body, various medical devices, infusion containers, and the like.
  • a prefilled syringe (medicine administration device) in which a syringe is preliminarily filled with a chemical solution has been widely used.
  • a prefilled syringe it is not necessary to suck the drug solution from the vial into the syringe at the time of drug solution administration, and the time required for administration can be shortened.
  • a prefilled syringe includes a fixed part and a plunger.
  • the plunger is operated, and the drug filled in the liquid chamber of the fixed part is discharged into the body through an injection needle connected to the cylinder tip of the fixed part.
  • a small prefilled syringe with a small liquid chamber is used when a small amount of medicine is administered.
  • a drug is administered by puncturing the injection needle perpendicular to the skin, a large injection pressure is required, and in order to prevent the drug from leaking, it is necessary to strongly press the prefilled syringe against the skin.
  • the conventional small prefilled syringe does not have a structure suitable for continuing to press against the skin with a strong force and is difficult to use.
  • administering a small amount of drug of about 0.05 to 0.5 ml considering the administration to the upper layer of the skin, even if a small prefilled syringe with a small liquid quality is used, the user moves the plunger. There was a problem that it was difficult to recognize. Therefore, an injection method that can recognize completion of administration is required.
  • Patent Document 1 discloses a drug administration device with improved operability.
  • the drug administration device described in Patent Document 1 includes a cylinder having a liquid chamber for storing a drug, a pusher part that moves inside the cylinder, a gripping part, and a connecting part.
  • the pusher portion includes a rod-shaped plunger and a gasket.
  • the grip portion is provided along the outer periphery of the cylindrical body, and the connecting portion is formed between the cylindrical body and the end portion of the grip portion.
  • the grip portion since the grip portion is provided along the outer periphery of the cylindrical body, the grip portion can be easily gripped, and a force can be strongly applied to the pusher portion.
  • a medicine filling step is required.
  • the dose of drug when administration to the upper skin layer is taken into account is about 0.03 to 0.5 ml.
  • a general-purpose high-speed filling machine is used to fill the syringe with the medicine.
  • a general-purpose high-speed filling machine cannot be used, and the necessity of remodeling the high-speed filling machine, It is conceivable that the filling efficiency is reduced.
  • the present invention has been made in consideration of such a situation, and aims to improve operability with a simple configuration without causing the necessity of remodeling a general-purpose high-speed filling machine or reducing the filling efficiency.
  • An object of the present invention is to provide a drug administration device.
  • a drug administration device of the present invention includes a syringe, an exterior member, and a holder.
  • the syringe is formed at a cylindrical side peripheral part forming a medicine chamber containing a medicine, a discharge part formed at one end in the axial direction of the side peripheral part, and the other end in the axial direction of the side peripheral part. And a flange portion.
  • An exterior member is formed in the cylinder shape which covers the side periphery in a syringe.
  • the holder has a flange support portion, a side periphery support portion, and a locking portion, and is interposed between the syringe and the exterior member.
  • a flange support part supports the flange part of a syringe.
  • a side periphery support part supports the side periphery part of a syringe.
  • the locking portion is locked to a locking receiving portion provided on the exterior member.
  • the diameter of a small syringe having a small liquid chamber can be increased by interposing a holder between the exterior member and the syringe, and the operability can be improved with a simple configuration. Can do. Moreover, since a syringe with a general shape can be used, a general-purpose high-speed filling machine can be used.
  • FIG. 1 is a perspective view showing a drug administration device according to a first embodiment of the present invention.
  • 1 is an exploded perspective view showing a drug administration device according to a first embodiment of the present invention.
  • FIG. 1 is a cross-sectional view showing a drug administration device according to a first embodiment of the present invention. It is sectional drawing which shows the exterior member of the chemical
  • FIG. 16A is sectional drawing which shows the state after administering a chemical
  • FIG. 16B expands and shows the principal part of FIG. It is sectional drawing.
  • a drug administration device according to an embodiment of the present invention will be described below with reference to FIGS.
  • symbol is attached
  • the present invention is not limited to the following form. The description will be given in the following order. 1.
  • FIG. 1 is a perspective view showing a drug administration device of this example.
  • FIG. 2 is an exploded perspective view of the administration device body according to the drug administration device of the present example.
  • FIG. 3 is a cross-sectional view showing the drug administration device of this example.
  • the drug administration device 1 includes an administration device body 2 and a cap 3 that is detachably attached to the administration device body 2.
  • the administration device main body 2 includes a syringe 11, a pusher member 12, an exterior member 13 attached to the syringe 11, and a holder 14 that supports the syringe.
  • the syringe 11 is a prefilled syringe that is pre-filled with a medicine P (see FIG. 3).
  • the syringe 11 has a side peripheral portion 21 formed in a substantially cylindrical shape and a discharge portion 22 formed at one end of the side peripheral portion 21.
  • a liquid chamber 23 for storing the medicine P is formed inside the side peripheral portion 21.
  • the diameter of the side peripheral portion 21 is appropriately set according to the use and the volume of the medicine accommodated in the liquid chamber 23.
  • the outer diameter of the side peripheral portion 21 is preferably set to 8.1 to 9.4 mm.
  • Examples of the chemical solution P include various vaccines for preventing various infectious diseases such as influenza, but are not limited to vaccines.
  • drugs P other than vaccines include glucose injection solutions such as glucose, electrolyte correction injection solutions such as sodium chloride and potassium lactate, vitamin agents, antibiotic injection solutions, contrast agents, steroid agents, and proteolytic enzymes. Inhibitors, fat emulsions, anticancer agents, anesthetics, heparin calcium, antibody drugs and the like.
  • a flange portion 24 is provided at the other end portion of the side peripheral portion 21.
  • the flange portion 24 protrudes radially outward from the outer peripheral surface at the other end portion of the side peripheral portion 21, and the outer peripheral contour is formed in a substantially elliptical shape.
  • the contour of the outer periphery of the flange portion 24 is formed by two arc sides 24a facing each other and two linear sides 24b continuing from the two arc sides 24a and facing each other.
  • the two arc sides 24 a are engaged with an engaging claw 46 described later of the flange support portion 41 constituting the holder 14.
  • the diameter of the circle formed by the two arc sides 24a in the flange portion 24 is set to 13 to 19 mm, for example.
  • the axial length of the side peripheral portion 21 is set in the range of 47 to 60 mm, for example. Further, when the cap 3 to be described later is attached, the length from the flange portion 24 to the tip of the cap 3 is set in the range of 79 to 92 mm, for example.
  • the discharge part 22 is continuous with one end of the side peripheral part 21 and is formed in a substantially cylindrical shape coaxial with the side peripheral part 21.
  • the discharge part 22 is formed in a tapered shape whose diameter continuously decreases toward the tip that is opposite to the side peripheral part 21.
  • the cylindrical hole of the discharge part 22 communicates with the cylindrical hole of the side peripheral part 21.
  • the luer lock part 26 which shows an example of a tip member is joined to the discharge part 22.
  • the luer lock portion 26 includes a cylindrical portion 27 formed in a substantially cylindrical shape coaxial with the discharge portion 22, and a fitting portion 28 provided at an end portion of the cylindrical portion 27 on the side peripheral portion 21 side. .
  • the cylinder part 27 is formed in a substantially hexagonal column shape.
  • the outermost diameter of the cylindrical portion 27 is set larger than the outer diameter of the side peripheral portion 21, and a gap of a predetermined distance is formed between the inner peripheral surface of the cylindrical portion 27 and the outer peripheral surface of the discharge portion 22. It is formed.
  • An internal thread portion 27 a is formed on the inner peripheral surface of the cylindrical portion 27.
  • the fitting portion 28 includes a plurality of protrusions 28 a that protrude radially inward from the inner peripheral surface of the cylindrical portion 27.
  • the plurality of protrusions forming the fitting portion 28 are arranged at an appropriate interval in the circumferential direction of the cylindrical portion 27.
  • the fitting portion 28 is fitted to a base portion (an end portion on the side peripheral portion 21 side) of the discharge portion 22.
  • the tip member attached to the discharge part 22 is not limited to the luer lock part 26, and for example, various other members such as a safety member for improving the safety of drug administration in the drug administration device 1 are applied.
  • Examples of the material of the syringe 11 include polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate. And various resins such as polyester such as butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12). Among them, it is preferable to use a resin such as polypropylene, cyclic polyolefin, polyester, or poly- (4-methylpentene-1) in terms of easy molding. In addition, it is preferable that the material of the syringe 11 is substantially transparent in order to ensure internal visibility.
  • a needle holding member is attached to the discharge portion 22 of the syringe 11.
  • the needle holding member includes a needle tube and a needle hub that holds the needle tube.
  • the needle hub may be directly attached to the discharge part 22, and is attached to the syringe 11 by being screwed to the luer lock part 26.
  • the needle holding member is attached to the discharge portion 22, the needle hole of the needle tube and the inside of the discharge portion 22 are in fluid-tight communication.
  • the drug administration device 1 is not limited to the one used by attaching the needle holding member.
  • the drug administration device 1 may be used by connecting the discharge portion 22 to a connector (a female luer) provided on a medical tube.
  • the pusher member 12 includes a gasket 31 that is movably disposed inside the side peripheral portion 21 of the syringe 11, and a plunger 32 that is connected to the gasket 31. By operating this pusher member 12, the medicine P stored in the syringe 11 is discharged.
  • the gasket 31 is formed in a substantially cylindrical shape.
  • the gasket 31 moves while being in liquid tight contact with the inner peripheral surface of the side peripheral portion 21 of the syringe 11.
  • the gasket 31 partitions the space in the side peripheral portion 21 into two.
  • the space on the discharge portion 22 side of the gasket 31 in the side peripheral portion 21 and the space in the discharge portion 22 become a liquid chamber 23 filled with the medicine P.
  • a plunger main body 34 described later of the plunger 32 is disposed in a space on the other end side of the gasket 31 in the side peripheral portion 21.
  • One end portion of the gasket 31 is formed in a tapered shape whose diameter continuously decreases toward the tip. This taper shape corresponds to the shape of the inner surface at one end of the side peripheral portion 21. Therefore, when the gasket 31 is moved to the one end portion side of the side peripheral portion 21, one end portion of the gasket 31 comes into contact with the inner surface of the one end portion of the side peripheral portion 21 so that no gap is generated.
  • a fitting hole 31 a is provided on the other end surface of the gasket 31.
  • the material of the gasket 31 is not particularly limited, but is preferably made of an elastic material in order to improve the liquid tightness with the side peripheral portion 21.
  • the elastic material include various rubber materials such as natural rubber, isobutylene rubber, and silicone rubber, various thermoplastic elastomers such as olefin and styrene, and mixtures thereof.
  • the plunger 32 has a plunger main body 34 connected to the gasket 31 and an operation unit 36 for operating the plunger main body 34.
  • As the material of the plunger 32 various resins mentioned as the material of the syringe 11 can be applied.
  • the plunger body 34 is formed in a substantially cylindrical shape.
  • a connection projection 37 is provided at one end of the plunger body 34.
  • the connection protrusion 37 is formed in a substantially cylindrical shape coaxial with the plunger main body 34, and is connected by press-fitting into the gasket 31.
  • On the outer peripheral surface of the connection protrusion 37 a male screw portion that is screwed into the female screw portion of the gasket 31 is formed.
  • the connection method of the connection protrusion 37 and the gasket 31 is not limited to the connection by press-fitting of the connection protrusion 37, For example, other connection methods, such as screwing and the connection using an adhesive agent, are employ
  • the operation unit 36 is provided at the other end of the plunger main body 34.
  • the operation unit 36 is formed in a substantially disc shape.
  • the gasket 31 provided at the tip of the plunger 32 moves inside the side peripheral portion 21 of the syringe 11.
  • the exterior member 13 is formed in a substantially cylindrical shape that covers the outer peripheral surface of the side peripheral portion 21 in the syringe 11 and the outer peripheral surface of the cylindrical portion 27 in the luer lock portion 26.
  • the inner diameter of the exterior member 13 is set larger than the outer diameters of the side peripheral portion 21 and the cylindrical portion 27.
  • FIG. 4 is a cross-sectional view showing the exterior member 13.
  • four guide pieces 51 and four locking receiving portions 52 are provided on the inner wall 13 a at the substantially central portion in the axial direction of the exterior member 13.
  • the four guide pieces 51 are arranged on the inner wall 13a of the exterior member 13 at substantially equal intervals.
  • the guide piece 51 is formed in a substantially flat plate shape.
  • the guide piece 51 projects substantially vertically from the inner wall 13 a of the exterior member 13 along the axial direction of the exterior member 13.
  • the four latch receiving portions 52 are provided on one side of the guide piece 51 in the axial direction.
  • the four latch receiving portions 52 are disposed between two adjacent guide pieces 51.
  • the locking receiving portion 52 has an inclined surface 52 a that is inclined from the inner wall 13 a toward the axis of the exterior member 13 as it goes from the other side of the exterior member 13 to one side. Therefore, the inner diameter of the portion of the exterior member 13 where the four locking receiving portions 52 are provided is reduced in diameter as it goes from the other side in the axial direction to the one side by the four locking receiving portions 52. And the recessed part 49 of the holder 14 mentioned later latches to this latching receiving part 52 (refer FIG. 7).
  • an outer flange portion 53 is formed at the other axial end of the exterior member 13.
  • the outer flange portion 53 protrudes from the outer peripheral surface of the exterior member 13 substantially perpendicularly outward in the radial direction.
  • FIG. 5 is a perspective view showing the holder 14.
  • the holder 14 is formed in a substantially cylindrical shape that covers the outer peripheral surfaces of the flange portion 24 and the side peripheral portion 21 of the syringe 11.
  • the holder 14 is interposed between the syringe 11 and the exterior member 13 (see FIG. 3).
  • the holder 14 includes a flange support portion 41 that supports the flange portion 24 of the syringe 11, a side peripheral support portion 42, and a connecting portion 43 that is provided between the flange support portion 41 and the side peripheral support portion 42. Yes.
  • the flange support part 41 is formed in a substantially cylindrical shape. On one side in the axial direction of the flange support portion 41, two arc portions 41a facing each other and two linear portions 41b continuing to the two arc portions 41a and facing each other are provided. The interval in the direction in which the two linear portions 41 b face each other is set so that the linear side 24 b of the flange portion 24 in the syringe 11 is substantially equal to the interval in the direction in which they face each other. Further, on the other side in the axial direction of the flange support portion 41, a ring portion 44 that is continuous with two arc portions and two straight portions is provided.
  • An engagement claw 46 and an opening 47 are provided on the inner walls of the two arc portions 41a.
  • the opening 47 is formed on one end side in the axial direction of the flange support portion 41.
  • the engaging claw 46 is formed on the other side in the axial direction of the flange support 41 than the opening 47.
  • the engaging claw 46 is inclined so as to continuously separate from the inner wall of the flange support portion 41 as it approaches the opening 47.
  • FIG. 6 is a perspective view showing a state in which the holder 14 is attached to the syringe 11. As shown in FIG. 6, the arc side 24 a of the flange portion 24 of the syringe 11 is inserted into the opening 47 provided in the arc portion 41 a of the holder 14, and the engagement claw 46 and the arc side 24 a are engaged. Further, the straight side 24 b of the flange portion 24 is fitted between the two straight portions 41 b of the holder 14.
  • a connecting portion 43 is continuously provided at one end of the flange support portion 41 in the axial direction.
  • the connecting portion 43 is an outer flange that protrudes radially outward from one end of the flange support portion 41 in the axial direction.
  • a side periphery support portion 42 is provided on the end surface of the connecting portion 43 opposite to the flange support portion 41.
  • the side periphery support part 42 is formed in a substantially cylindrical shape.
  • Four cutouts 42a extending in the axial direction are formed in the side support 42.
  • the four notches 42a are provided from one end in the axial direction to the vicinity of the other end.
  • the four notches 42 a are formed at substantially equal intervals along the radial direction of the side periphery support portion 42.
  • the front end portion 48a which is one side in the axial direction of the four support pieces 48 is formed in a substantially triangular shape.
  • the tip portions 48 a of the four support pieces 48 are continuously inclined toward the axial center of the side peripheral support portion 42 from the other side in the axial direction to one side. That is, one end portion in the axial direction of the side support 42 is formed in a tapered shape whose diameter continuously decreases toward the tip.
  • the diameter of the opening at one end in the axial direction of the side circumferential support portion 42 is set to be substantially equal to the outer diameter of the side circumferential portion 21 of the syringe 11. As shown in FIG. 6, the side peripheral portion 21 of the syringe 11 is supported by the four support pieces 48.
  • the axial length of the support piece 48 is set shorter than the length from the flange portion 24 in the syringe 11 to the gasket 31 inserted in the side peripheral portion 21. Therefore, the outer peripheral surface of the liquid chamber 23 in the syringe 11 is exposed from the tip 48 a of the support piece 48.
  • a concave portion 49 showing an example of a locking portion is provided in the vicinity of the front end portion 48a of the support piece 48.
  • the concave portion 49 is formed along the circumferential direction of the side circumferential support portion 42.
  • the recessed portion 49 is recessed from the outer peripheral surface of the support piece 48 toward the radially inward direction of the side peripheral support portion 42. For this reason, the portion of the side support portion 42 where the recess 49 is formed has a reduced diameter.
  • FIG. 7 is a cross-sectional view showing a state where the holder 14 is mounted on the exterior member 13. As shown in FIG. 7, the guide piece 51 of the exterior member 13 is inserted into the notch 42 a of the side periphery support portion 42 in the holder 14. The recessed portion 49 is engaged with the engagement receiving portion 52 of the exterior member 13.
  • the material of the exterior member 13 and the holder 14 various resins mentioned as the material of the syringe 11 can be applied.
  • the material of the exterior member 13 and the holder 14 is substantially transparent in order to ensure internal visibility.
  • the example which provided the guide piece 51 of the exterior member 13, the notch 42a of the holder 14, and the four support pieces 48 was demonstrated in this example, it is not limited to this.
  • five or more guide pieces 51, notches 42, and support pieces 48 may be provided.
  • the number and positional relationship of the guide piece 51, the notch 42, and the support piece 48 are provided so as to correspond to each other.
  • the cap 3 is formed in a bottomed substantially cylindrical shape having a discharge portion insertion hole 73, and has a large-diameter portion 71 that forms one end portion in the axial direction and the other end portion in the axial direction. And a small-diameter portion 72 that forms the shape.
  • the large diameter portion 71 has a larger diameter than the small diameter portion 72.
  • a plurality of grooves 71 a extending along the axial direction of the cap 3 are formed on the outer peripheral surface of the large diameter portion 71.
  • the groove 71a is provided to increase the frictional resistance generated between the cap 3 and fingers when the user removes the cap 3 from the syringe 11.
  • a male screw portion 72a that is screwed into a female screw portion 27a formed in the luer lock portion 26 of the syringe 11 is formed.
  • the discharge part insertion hole 73 extends along the axial direction of the cap 3. One end of the discharge portion insertion hole 73 is opened in the end face of the small diameter portion 72, and the other end is located in the middle portion of the large diameter portion 71. A packing 76 made of a substantially cylindrical elastic member (for example, rubber) is fitted to the other end side of the discharge portion insertion hole 73.
  • a packing convex portion 77 protruding in the axial direction of the cap 3 is formed at a substantially central portion of the packing 76.
  • the packing convex part 77 seals the discharge port of the discharge part 22. Thereby, it can prevent that the chemical
  • the discharge part 22 of the syringe 11 is inserted into the discharge part insertion hole 73 of the cap 3.
  • the small diameter portion 72 of the cap 3 is inserted into the cylindrical portion 27 of the luer lock portion 26.
  • the cap 3 is rotated in the attaching direction.
  • the male screw portion 72 a of the small diameter portion 72 is screwed into the female screw portion 27 a of the luer lock portion 26, and the packing convex portion 77 seals the discharge port of the discharge portion 22.
  • wearing of the cap 3 to the administration instrument main body 2 of the cap 3 is completed.
  • FIG.8 and FIG.9 is sectional drawing which shows the assembly procedure of the chemical
  • the luer lock portion 26 is joined to the discharge portion 22 of the syringe 11. That is, the fitting portion 28 of the luer lock portion 26 is fitted and fixed to the discharge portion 22. Then, the male screw portion 72 a of the cap 3 is screwed into the female screw portion 27 a of the luer lock portion 26, and the cap 3 is attached to the luer lock portion 26. Thereby, the discharge port of the discharge part 22 in the syringe 11 is sealed by the packing 76.
  • the medicine P is filled into the side peripheral portion 21 of the syringe 11.
  • the gasket 31 of the pusher member 12 is inserted into the side peripheral portion 21 from the other end of the side peripheral portion 21 of the syringe 11.
  • the gasket 31 is inserted into the side peripheral portion 21 by, for example, mechanical plugging or vacuum plugging.
  • the holder 14 is inserted from the opening on the other side in the axial direction of the exterior member 13. That is, the distal end portion 48 a of the support piece 48 is inserted between two adjacent guide pieces 51 of the four guide pieces 51 provided on the exterior member 13. As a result, the guide piece 51 enters the notch 42 a of the side peripheral support portion 42 in the holder 14. Thereby, while the rotation in the circumferential direction in the holder 14 is controlled by the guide piece 51 of the exterior member 13, the holder 14 can be moved in the axial direction without rattling.
  • the syringe 11 attached with the cap 3 is inserted into the holder 14 temporarily attached to the exterior member 13.
  • a concave portion 49 that is recessed toward the axial center of the holder 14 is provided in the vicinity of the tip 48 a of the holder 14. For this reason, when the syringe 11 is inserted into the holder 14, the cap 3 attached to the discharge portion 22 side of the syringe 11 comes into contact with the inner wall of the recess 49.
  • the support piece 48 of the holder 14 is pushed by the cap 3 and elastically deforms toward the radially outward direction of the side peripheral support portion 42. Accordingly, the opening on the one end side in the axial direction of the side periphery support portion 42 is enlarged. As a result, as shown in FIG. 9C, the cap 3, the luer lock portion 26 and the side peripheral portion 21 attached to the distal end portion of the syringe 11 protrude from one end in the axial direction of the side peripheral support portion 42 in the holder 14.
  • the arc side 24 a of the flange portion 24 of the syringe 11 gets over the engagement claw 46 provided on the flange support portion 41 and is engaged with the engagement claw 46.
  • the engaging claw 46 is inclined toward the axial center side of the flange support portion 41 as it goes from the other side in the axial direction to one side. Therefore, the arc side 24 a of the flange portion 24 can easily get over the engaging claw 46.
  • the two straight sides 24 b of the flange portion 24 are arranged so as to face the two straight portions 41 b of the flange support portion 41, and the two arc sides 24 a are arcs of the flange support portion 41. It fits into the opening 47 provided in the part 41a.
  • the holder 14 is attached to the syringe 11 in a state where the rotation of the syringe 11 in the circumferential direction is restricted.
  • the latching receiving portion 52 is provided with an inclined surface 52a, and a part of the inner diameter of the exterior member 13 is reduced. Therefore, when the distal end portion 48 a comes into contact with the inclined surface 52 a of the latch receiving portion 52, the support piece 48 is elastically deformed by the latch receiving portion 52, and one side in the axial direction of the side peripheral support portion 42 is reduced in diameter. Thereby, the four front-end
  • connection member such as a connector (a female luer) provided on a needle holding member or a medical tube can be easily attached.
  • the exterior member 13 can be easily attached to a general syringe without changing the shape of the syringe 11.
  • the plunger main body 34 of the pusher member 12 is inserted into the side peripheral portion 21 of the syringe 11, and the gasket 31 and the plunger main body 34 are connected. Thereby, the medicine administration device 1 is assembled.
  • the axial length of the support piece 48 is set to be shorter than the length from the flange portion 24 of the syringe 11 to the gasket 31 inserted into the side peripheral portion 21. That is, the outer peripheral surface of the liquid chamber 23 in the syringe 11 in which the medicine P is accommodated is not covered with the holder 14. Therefore, it is possible to prevent the state of the medicine P accommodated in the liquid chamber 23 of the syringe 11 from becoming difficult to see with the holder 14.
  • FIG. 10 is a perspective view of a drug administration device according to a second embodiment of the present invention.
  • FIG. 11 is an exploded perspective view of the drug administration device according to the second embodiment of the present invention.
  • the drug administration device 81 according to the second embodiment of the present invention has the same configuration as the drug administration device 1 of the first embodiment described above.
  • the difference between the drug administration device 81 and the drug administration device 1 of the first embodiment is the configuration of the exterior member, the pusher member, and the holder. Therefore, here, the exterior member, the pusher member, and the holder will be described, and the same reference numerals are given to the portions that are common to the drug administration device 1, and redundant descriptions are omitted.
  • the drug administration device 81 includes an administration device body 82 and a cap 3.
  • the administration instrument main body 82 includes a syringe 11, a pusher member 12A, an exterior member 83 attached to the syringe 11, and a holder 91 that supports the syringe.
  • the exterior member 83 is formed in a substantially cylindrical shape that covers the outer peripheral surface of the side peripheral portion 21 in the syringe 11.
  • the inner diameter of the exterior member 83 is set to be larger than the outer diameters of the side peripheral portion 21 and the cylindrical portion 27 of the luer lock portion 26.
  • the four locking receiving portions 84 are formed on one side of the exterior member 83 in the axial direction.
  • the four latch receiving portions 84 are openings that penetrate from the inner wall 83a of the exterior member 83 to the outer peripheral surface.
  • the four latch receiving portions 84 are provided at predetermined intervals in the circumferential direction of the exterior member 83.
  • an outer flange portion 86 and a plurality of support protrusions 87 are formed on the other end of the exterior member 83 in the axial direction.
  • the outer flange portion 86 protrudes from the outer peripheral surface of the exterior member 13 substantially perpendicularly outward in the radial direction.
  • FIG. 12 is a perspective view showing the main parts of the exterior member 83 and the pusher member 12A.
  • the plurality of support protrusions 87 are provided on the inner peripheral surface of the exterior member 13 at equal intervals along the circumferential direction. Further, the plurality of support protrusions 87 protrude substantially perpendicularly in the radial inward direction from the inner peripheral surface of the exterior member 13. And the substantially circular opening part is formed by the front-end
  • the plurality of support protrusions 87 engage with a pair of convex portions 39A of a pusher member 12A described later.
  • the pusher member 12 ⁇ / b> A includes a gasket 31 and a plunger 32 ⁇ / b> A, similarly to the pusher member 12 according to the first embodiment. Since the configuration of the gasket 31 is the same as that of the gasket 31 according to the first embodiment, the description thereof is omitted here.
  • the plunger 32A has a plunger main body 34A connected to the gasket 31, an operation part 36A for operating the plunger main body 34A, a hook receiving part 38A, and a pair of convex parts 39A.
  • the plunger main body 34A is formed in a substantially cylindrical shape.
  • a connection projection 37A is provided at one end of the plunger main body 34A.
  • the gasket 31 is connected to the connection protrusion 37A.
  • the operation portion 36A is provided at the other end portion of the plunger main body 34A, and is formed in a substantially disc shape.
  • the hook receiving portion 38A is provided in the approximate center of the plunger main body 34A in the axial direction.
  • the hook receiving portion 38A protrudes radially outward from the side surface of the plunger main body 34A.
  • the hook receiving portion 38A is formed in a substantially trapezoidal shape in cross section along the axial direction of the plunger main body 34A (see FIG. 15). And hook receiving part 38A engages with hook piece 98 of holder 91 mentioned below when a medicine is administered (refer to Drawing 16B).
  • the pair of convex portions 39A are provided between the hook receiving portion 38A in the axial direction and the operation portion 36A in the plunger main body 34A.
  • the pair of convex portions 39A are flanges that protrude radially outward from the side surface of the plunger main body 34A.
  • the pair of convex portions 39A is formed at a predetermined interval in the axial direction of the plunger main body 34A.
  • the plunger main body 34 ⁇ / b> A is inserted into the cylindrical hole of the exterior member 83 from the opening formed by the plurality of support protrusions 87 of the exterior member 83.
  • the support protrusion 87 of the exterior member 83 enters between the pair of convex portions 39A, and the pair of convex portions 39A and the support protrusion 87 are engaged.
  • FIG. 13 is an exploded perspective view showing the holder 91
  • FIG. 14 is a perspective view showing a state where the holder 91 is attached to the syringe 11
  • FIG. 15 is a cross-sectional view showing the drug administration device 81.
  • FIG. 16A is a cross-sectional view showing a state after the medicine is administered
  • FIG. 16B is an explanatory view showing an enlarged main part of FIG. 16A.
  • the holder 91 has a first part 92A and a second part 92B. As shown in FIG. 14, the holder 91 is formed in a substantially cylindrical shape by combining the first component 92A and the second component 92B. Since the first component 92A and the second component 92B have the same configuration, only the first component 92A will be described here.
  • the first component 92 ⁇ / b> A has a side periphery support portion 93 and a tip portion 96.
  • the side periphery support part 93 is formed in a semi-cylindrical shape.
  • the curvature radius of the side peripheral support portion 93 is set to be approximately equal to the curvature radius of the inner diameter of the exterior member 83.
  • the outer peripheral surface 93a of the side peripheral support part 93 is formed in a substantially curved surface shape.
  • Two locking claws 94 showing another example of the locking portion are provided on the outer peripheral surface 93a. That is, the holder 91 has four locking claws 94 in combination with the first component 92A and the second component 92B. The four locking claws 94 of the holder 91 are locked to the four locking receiving portions 84 of the exterior member 83.
  • a plurality of protrusions 99 extending along the axial direction of the side periphery support portion 93 are formed on the outer peripheral surface 93a.
  • the plurality of protrusions 99 are arranged at predetermined intervals along the circumferential direction of the outer peripheral surface 93a.
  • a distal end portion 96 is continuously formed at one end of the side periphery support portion 93 in the axial direction.
  • the tip 96 is formed in a semi-conical shape.
  • the curvature radius of the distal end portion 96 on the side peripheral support portion 93 side is set to be larger than the curvature radius of the side peripheral support portion 93. Therefore, a step surface 96 a is formed between the distal end portion 96 and the outer peripheral surface 93 a of the side peripheral support portion 93.
  • tip part 96 are provided with the semi-cylindrical support hole 95 extended along the axial direction.
  • the support hole 95 is formed on the facing surface 93b of the first component 92A that faces the second component 92B.
  • the curvature radius of the support hole 95 is set to be substantially equal to the curvature radius of the side peripheral portion 21 of the syringe 11.
  • the side periphery 21 of the syringe 11 is attached to the support hole 95.
  • an engaging portion 97 indicating a flange supporting portion is provided on the other side in the axial direction of the side peripheral supporting portion 93.
  • the engaging portion 97 is an opening that penetrates from the outer peripheral surface 93 a of the side peripheral support portion 93 to the opposing surface 93 b.
  • the arc portion 24 a of the flange portion 24 in the syringe 11 is engaged with the engaging portion 97.
  • the flange portion 24 is supported by sandwiching the flange portion 24 between the engaging portion 97 of the first component 92A and the engaging portion 97 of the second component 92B.
  • the straight side 24 b of the flange portion 24 abuts on the engaging portion 97. Therefore, the movement of the syringe 11 in the axial direction and the movement of the side peripheral portion 21 around the circumferential direction are restricted.
  • a hook piece 98 is provided at the other end in the axial direction of the side periphery support portion 93.
  • the hook piece 98 protrudes in the axial direction from the other end surface in the axial direction of the side peripheral support portion 93.
  • the hook piece 98 is engaged with a hook piece receiving portion 38A provided on the plunger main body 34A after the pusher member 12 is operated to administer the medicine.
  • the hook piece 98 gets over the hook piece receiving portion 38A, a click feeling is generated. With this click feeling, it is possible to notify the user that the administration of the medicine has been completed.
  • the strength of the click feeling generated by the hook piece 98 and the hook piece receiving portion 38A can be adjusted by the difference in hardness depending on the size and material of the hook piece 98 and the hook piece receiving portion 38A.
  • the lengths in the axial direction of the first component 92A and the second component 92B are set to be shorter than the length from the flange portion 24 in the syringe 11 to the gasket 31 inserted in the side peripheral portion 21 (see FIG. 15). ). Therefore, as shown in FIG. 14, a part of the side peripheral portion 21 of the syringe 11 and the luer lock portion 26 attached to the discharge portion 22 are exposed from the distal end portion 96 of the holder 91.
  • the luer lock part 26 and the cap 3 are attached to the syringe 11 in advance, and the side periphery 21 of the syringe 11 is filled with the medicine P and the gasket 31 is plugged.
  • the arc side 24 a of the flange portion 24 of the syringe 11 is fitted into the engaging portion 97 of the first component 92 ⁇ / b> A, and the arc side 24 a is engaged with the engaging portion 97.
  • approximately half of the circumferential direction of the side peripheral portion 21 of the syringe 11 is fitted into the support hole 95 of the first component 92 ⁇ / b> A.
  • the opposing surface 93b of the first component 92A and the opposing surface 93b of the second component 92B are opposed, and the first component 92A and the second component 92B are overlapped.
  • the remaining arc side 24a is engaged with the engaging portion 97 of the second component 92B.
  • the remaining half of the side peripheral portion 21 in the syringe 11 is fitted into the support hole 95 of the second component 92B.
  • the syringe 11 is supported by the holder 91 in a state where a part of the side peripheral portion 21, the luer lock portion 26 attached to the discharge portion 22 and the cap 3 are exposed from the distal end portion 96.
  • the two arc sides 24a of the flange portion 24 are sandwiched between the first part 92A and the second part 92B from the left and right sides. Furthermore, the curvature radius of the support hole 95 is set to be substantially equal to the curvature radius of the side peripheral portion 21 of the syringe 11. As a result, not only the rotation in the circumferential direction and the movement in the axial direction in the holder 91 in the syringe 11 are restricted, but also the syringe 11 can be prevented from rattling in the holder 91.
  • the side peripheral support portion 93 of the holder 91 attached to the syringe 11 is inserted from an opening on one side in the axial direction of the exterior member 83. Then, the four locking claws 94 provided on the first component 92 ⁇ / b> A and the second component 92 ⁇ / b> B are locked to the locking receiving portion 84 provided on the exterior member 83. Thereby, the holder 91 is interposed between the syringe 11 and the exterior member 83.
  • the stepped surface 96a of the holder 91 abuts on one end surface of the exterior member 83 in the axial direction.
  • the curvature radii of the side support portions 93 of the first component 92A and the second component 92B are set to be substantially equal to the curvature radius of the inner diameter of the exterior member 83.
  • the outer peripheral surface 93a of the holder 91 is provided with a plurality of ridges 99 extending along the axial direction of the side peripheral support portion 93.
  • the plunger body 34 ⁇ / b> A of the pusher member 12 ⁇ / b> A is inserted from the opening formed by the plurality of support protrusions 87 of the exterior member 83.
  • the plunger main body 34A is inserted into the side peripheral portion 21 of the syringe 11, and the gasket 31 and the plunger main body 34A are connected.
  • the pair of convex portions 39A of the plunger main body 34A and the support protrusions 87 of the exterior member 83 are engaged.
  • the drug administration device 81 is assembled.
  • the outer peripheral surface of the liquid chamber 23 in which the medicine P in the syringe 11 is housed is the exterior member 83 and the holder. 91 is not covered. That is, since there is nothing blocking the outer peripheral surface of the liquid chamber 23 of the syringe 11, the state of the medicine P accommodated in the liquid chamber 23 can be easily seen.
  • FIG. 17 is a perspective view of a drug administration device according to a third embodiment.
  • 18 is an exploded perspective view showing the holder, and
  • FIG. 19 is a cross-sectional view showing the drug administration device.
  • the holder and the exterior member of the drug administration device 81 according to the above-described second embodiment are disposed up to the discharge portion 22 in the syringe, that is, the tip member. It is an extension. Therefore, here, the same reference numerals are given to the parts common to the drug administration device 81 according to the second embodiment, and the duplicated description is omitted.
  • the drug administration device 101 includes an administration device main body 102 and a cap (not shown).
  • the administration instrument main body 102 includes a syringe 11A, a pusher member 12A, an exterior member 103 attached to the syringe 11, and a holder 111 that supports the syringe.
  • the flange portion 24A of the syringe 11A according to the third embodiment is formed in a substantially disc shape.
  • the exterior member 103 is formed in a substantially cylindrical shape that covers the syringe 11 ⁇ / b> A on the outer peripheral surface of the side peripheral portion 21 ⁇ / b> A and the peripheral surface of the cylindrical portion 27 in the luer lock portion 26. Further, the inner diameter of the exterior member 103 is set larger than the outer diameters of the side peripheral portion 21 and the cylindrical portion 27.
  • four locking receiving portions 104 are provided on the exterior member. The four latch receiving portions 104 are openings that penetrate from the inner wall to the outer peripheral surface of the exterior member 103.
  • the material of the exterior member 103 is preferably substantially transparent in order to ensure internal visibility. And as a material of the exterior member 103, various resin quoted as a material of the syringe 11A can be applied.
  • the exterior member 103 is provided with an outer flange portion 106 and a support protrusion 107 (see FIG. 19), similarly to the exterior member 83 according to the second embodiment.
  • FIGS. 18 is an exploded perspective view showing the holder 111
  • FIG. 19 is a cross-sectional view showing the drug administration device 101.
  • the holder 111 is formed in a substantially cylindrical shape by combining the first component 112A and the second component 112B.
  • the axial length of the holder 111 is set to be approximately equal to the length from the flange portion 24A to the luer lock portion 26 attached to the discharge portion 22A in the syringe 11A. Therefore, the holder 111 is attached to the syringe 11A so as to cover the outer peripheral surface from the flange portion 24 to the discharge portion 22A, that is, the luer lock portion 26.
  • first component 112A and the second component 112B have the same configuration, only the first component 112A will be described here.
  • the first part 112A has a side periphery support portion 113 and a tip portion 116.
  • the side periphery support part 113 is formed in a semi-cylindrical shape.
  • the curvature radius of the side periphery support portion 113 is set to be approximately equal to the curvature radius of the inner diameter of the exterior member 103. Therefore, as shown in FIG. 19, when the holder 111 and the exterior member 103 are combined, the outer peripheral surface 113 a of the side peripheral support portion 113 comes into contact with the inner wall of the exterior member 103.
  • two locking claws 114 showing another example of the locking portion are provided on the outer peripheral surface 113 a of the side peripheral support portion 113. That is, the holder 111 has four locking claws 114 together with the first part 112A and the second part 112B. As shown in FIG. 17, the four locking claws 114 of the holder 111 are locked to the four locking receiving portions 104 of the exterior member 103.
  • an opening 119 is formed in the facing surface 113b facing and overlapping the second component 112B in the side periphery support portion 113.
  • the opening 119 is formed on one side in the axial direction of the side periphery support portion 113.
  • the opening part 120 is formed by the opening part 119 of the first part 112A and the opening part 119 of the second part 112B by combining the first part 112A and the second part 112B.
  • the opening window 120 is provided at a position facing the liquid chamber 23A in the syringe 11A.
  • the side periphery support part 113 is provided with a semi-cylindrical support hole 115 extending along the axial direction. In the support hole 115, the side peripheral portion 21A of the syringe 11 is mounted.
  • an engagement portion 117 indicating a flange support portion is provided on the other side in the axial direction of the side periphery support portion 113.
  • the engaging portion 117 is a groove portion that is recessed in a substantially arc shape from the facing surface 113b toward the radially outward direction.
  • the engaging portion 117 is engaged with a flange portion 24A in the syringe 11A.
  • the flange portion 24A is supported by sandwiching the flange portion 24A between the engagement portion 117 of the first component 112A and the engagement portion 117 of the second component 112B. Thereby, the movement of the syringe 11A in the axial direction is restricted.
  • a hook piece 118 is provided at the other axial end of the side support 113.
  • the hook piece 118 protrudes in the axial direction from the other end surface in the axial direction of the side peripheral support portion 113. After the drug is administered, the hook piece 118 is engaged with the hook piece receiving portion 38A of the pusher member 12A.
  • a distal end portion 116 is continuously provided at one end in the axial direction of the side periphery support portion 113.
  • the front end portion 116 is provided with a step surface 116 a with which one end of the exterior member 103 in the axial direction abuts.
  • the front end portion 116 is provided with a support recessed portion 116b that is recessed in a substantially trapezoidal shape.
  • the support recess 116 b is formed corresponding to the shape of the outer peripheral surface of the tube portion 27 of the luer lock portion 26.
  • the tip support recess 121 is formed by the support recess 116b of the first component 112A and the support recess 116b of the second component 112B.
  • the tip support recess 121 which is an example of the tip support portion, corresponds to the shape of the cylindrical portion 27 of the luer lock portion 26 and is a substantially hexagonal opening.
  • the outer peripheral surface of the cylindrical portion 27 abuts on the tip support concave portion 121.
  • the tip end side of the syringe 11 ⁇ / b> A in the axial direction is supported by the holder 111.
  • the side surface of the tip support concave portion 121 and the outer peripheral surface of the cylindrical portion 27 are in contact with each other, the rotation of the side peripheral portion 21 in the syringe 11A around the circumferential direction is restricted.
  • the shape of the opening of the tip support recess 121 is not limited to a substantially hexagonal shape, and is appropriately set according to the shape of the cylindrical portion 27 of the luer lock portion 26.
  • the holder 111 supports the flange portion 24A of the syringe 11A by the engaging portion 117 and supports the side peripheral portion 21A of the syringe 11A by the support hole 115. Furthermore, the holder 111 supports the luer lock portion 26 that is the distal end portion of the syringe 11 ⁇ / b> A by the distal end support recessed portion 121.
  • the embodiment of the drug administration device of the present invention has been described including its effects.
  • the drug administration device of the present invention is not limited to the above-described embodiment, and various modifications can be made without departing from the gist of the invention described in the claims.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'administration de médicament ayant une construction simple et un fonctionnement amélioré. Un dispositif d'administration de médicament (1) comprend une seringue (11), un élément extérieur (13) et un support (14). La seringue (11) comprend en outre une partie périphérique latérale tubulaire (21) et une partie de rebord (24) qui est formée sur une autre extrémité de la partie périphérique latérale (21) dans une direction axiale. L'élément extérieur (13) a la forme d'un tube qui couvre la partie périphérique latérale (21). Le support (14) a une partie de support de rebord (41), une partie de support de périphérie latérale (42) et une partie de mise en prise (49) et est interposé entre une seringue (11) et l'élément extérieur (43).
PCT/JP2012/077117 2012-10-19 2012-10-19 Dispositif d'administration de médicament WO2014061151A1 (fr)

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PCT/JP2012/077117 WO2014061151A1 (fr) 2012-10-19 2012-10-19 Dispositif d'administration de médicament

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Application Number Priority Date Filing Date Title
PCT/JP2012/077117 WO2014061151A1 (fr) 2012-10-19 2012-10-19 Dispositif d'administration de médicament

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002500934A (ja) * 1998-01-20 2002-01-15 セルジョ・レステッリ 使い捨て型の安全注射器
JP2008035913A (ja) * 2006-08-01 2008-02-21 Terumo Corp プレフィルドシリンジ及びその製造方法
JP2010535564A (ja) * 2007-08-10 2010-11-25 オーウェン マンフォード リミテッド 注射装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002500934A (ja) * 1998-01-20 2002-01-15 セルジョ・レステッリ 使い捨て型の安全注射器
JP2008035913A (ja) * 2006-08-01 2008-02-21 Terumo Corp プレフィルドシリンジ及びその製造方法
JP2010535564A (ja) * 2007-08-10 2010-11-25 オーウェン マンフォード リミテッド 注射装置

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