WO2013125135A1 - Composition favorisant l'absorption d'anthocyane - Google Patents

Composition favorisant l'absorption d'anthocyane Download PDF

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Publication number
WO2013125135A1
WO2013125135A1 PCT/JP2012/082536 JP2012082536W WO2013125135A1 WO 2013125135 A1 WO2013125135 A1 WO 2013125135A1 JP 2012082536 W JP2012082536 W JP 2012082536W WO 2013125135 A1 WO2013125135 A1 WO 2013125135A1
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anthocyanin
acid
unsaturated fatty
oil
anthocyanins
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PCT/JP2012/082536
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English (en)
Japanese (ja)
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孝司 一柳
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株式会社フードエビデンスリサーチ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/55—Linaceae (Flax family), e.g. Linum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Definitions

  • the present invention relates to an anthocyanin-containing composition with improved anthocyanin absorption into a living body.
  • Anthocyanins are widely present in nature, and are widely used as natural pigments in foods, pharmaceuticals, quasi drugs, cosmetics, and the like.
  • bilberry anthocyanins have been used mainly as medicines in Europe.
  • anthocyanin's functionality has attracted attention as a method of use other than anthocyanin pigments, and has a wide range of effects from vision improvement to antioxidant effects. Expected to be added to health foods.
  • Non-patent Document 1 a brain protective action that is considered to be derived from an antioxidant action has been found (Non-patent Document 1), and when administered to humans, Experimental results showing the effect of reducing eye strain by personal computer work have been obtained (Non-patent Document 2), and many health foods containing anthocyanins have appeared.
  • physiologically active substances not limited to anthocyanins
  • anthocyanins are orally administered and then absorbed from the gastrointestinal tract and circulate in the body through the blood to exert their pharmacological effects. Therefore, in order to effectively use the pharmacological effect in the living body, it must be efficiently taken into the living body from the digestive tract. That is, in order to efficiently exhibit pharmacological properties, it is desirable that the absorption rate into the living body is high.
  • Physiologically active substances such as anthocyanins absorbed in the living body are partly accumulated in organs and finally excreted in urine and in stool via bile. Therefore, the recovery rate in urine is proportional to the absorption rate in the body.
  • anthocyanins it has been reported that the recovery rate of non-metabolized and metabolized forms from urine (corresponding to the absorption rate in the living body) is very low. Even if it is high, it is less than 1% of the amount taken orally, and it is 0.1% or less for many anthocyanins. This is a great obstacle for the physiological activity of anthocyanins to be exhibited more effectively.
  • anthocyanins in consideration of the absorption of anthocyanins into the living body, in order to effectively exert physiological activity in humans, at least several hundred mg of anthocyanins must be ingested.
  • the present inventors have so far examined the function of anthocyanins contained in bilberry, and using bilberry extract containing many kinds and amounts as anthocyanins, the migration of anthocyanins to tissues in rats, In vivo absorption (bioavailability) has been reported (non-patent document 3). However, no attempt has been made to improve the absorption rate of anthocyanins into the living body so far.
  • Patent Document 1 studies on improving anthocyanin absorption using phytic acid (Patent Document 1) or lecithin
  • Patent Document 2 an anthocyanin-containing composition that has been nanoparticulate with a dispersant such as glycerin fatty acid ester
  • Patent Document 2 the toxicity of the additive and the like has been recognized, so it cannot be said that it is sufficient. Is the current situation.
  • the present invention aims to enhance in vivo absorbability of anthocyanins with low bioavailability, effectively absorb anthocyanins in vivo, and exhibit sufficient physiological activity with a lower dose of anthocyanins. It is an object of the present invention to provide an anthocyanin-containing composition that improves the absorbability of a living body.
  • bilberry extract was used as an anthocyanin-containing material, and when the composition was mixed with edible oils containing various unsaturated fatty acids or unsaturated fatty acids, The inventors have newly found that the absorbability into the body is remarkably improved, and have completed the present invention.
  • the basic aspect of the present invention is characterized in that the anthocyanin-containing material is mixed with at least one kind of unsaturated fatty acid having 14 or more carbon atoms or edible oil containing the unsaturated fatty acid.
  • An anthocyanin absorption promoting composition is characterized in that the anthocyanin-containing material is mixed with at least one kind of unsaturated fatty acid having 14 or more carbon atoms or edible oil containing the unsaturated fatty acid.
  • the anthocyanin-containing material is an anthocyanin-containing material extract, and in particular, the anthocyanin-containing material is derived from bilberry, blueberry, cassis (black currant), elderberry. Accelerating composition.
  • the present invention also provides an anthocyanin absorption promoting composition wherein the unsaturated fatty acid having 14 or more carbon atoms is selected from myristoleic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid.
  • an edible oil containing unsaturated fatty acid is an anthocyanin absorption promoting composition selected from rice germ oil, linseed oil, perilla oil, fish oil and the like.
  • the present invention relates to the promotion of anthocyanin absorption in which the mixing ratio of an anthocyanin-containing material and an unsaturated fatty acid having 14 or more carbon atoms or an edible oil containing the unsaturated fatty acid is 10: 1 to 10:10 It is a composition.
  • an anthocyanin absorption promoting composition having improved in vivo absorbability with respect to anthocyanins having low in vivo absorbability. Therefore, the composition provided by the present invention can effectively exert the pharmacological effect of anthocyanin with a small amount of anthocyanin intake, and further, the residence time in blood is prolonged, so that the physiological activity of anthocyanin is further increased. It can be sustained for a long time, and is effective for the development of functional foods containing anthocyanins.
  • FIG. 1 is a diagram showing the results of a test example, and shows the results of a mixed composition with edible oil.
  • FIG. 2 is a diagram showing the results of the test examples, and shows the results of the mixed composition with unsaturated fatty acids.
  • the present invention is basically an anthocyanin absorption promoting composition obtained by mixing an anthocyanin-containing material and at least one kind of an unsaturated fatty acid having 14 or more carbon atoms or an edible oil containing the unsaturated fatty acid. It is.
  • anthocyanin-containing material used in the present invention examples include various materials and are not particularly limited.
  • Various examples such as colored rice, black beans and black sesame can be exemplified.
  • those derived from bilberry, blueberry, cassis (black currant) and elderberry are preferable.
  • the anthocyanin-containing material is preferably an extract of the above-mentioned anthocyanin-containing material.
  • the extract can be obtained by a general method for preparing a plant extract, for example, an extraction method using a water-soluble solvent.
  • commercially available anthocyanin-containing extract extracts can also be used.
  • unsaturated fatty acids having 14 or more carbon atoms mixed with the anthocyanin-containing materials or edible oils containing the unsaturated fatty acids include myristoleic acid, palmitoleic acid, oleic acid, and linoleic acid. Linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, and the like. Accordingly, examples of edible oils containing these unsaturated fatty acids include rice germ oil, linseed oil, perilla oil, and fish oil. Needless to say, the unsaturated fatty acid having 14 or more carbon atoms or the edible oil containing the unsaturated fatty acid is not limited to these. Moreover, these C14 or more unsaturated fatty acids or the edible oil containing the said unsaturated fatty acid can be used individually or in combination of 2 or more types.
  • anthocyanin absorption promoting composition is a mixed composition of an anthocyanin-containing material and an unsaturated fatty acid having 14 or more carbon atoms, or an edible oil containing the unsaturated fatty acid. It was found that the mixing ratio of the anthocyanin-containing material and the unsaturated fatty acid having 14 or more carbon atoms or the edible oil containing the unsaturated fatty acid is preferably in the range of 10: 1 to 10:10. . If the ratio is less than 10: 1, the in vivo absorbability of anthocyanins will not be improved, and even if the mixture exceeds 10:10, that is, 1: 1, more in vivo absorbability will not be obtained, which is wasteful. Become.
  • bilberry is a shrub belonging to the genus Vaccinaceae, and many are known such as whortleberry, winberry, blaeberry, and European blueberry. Yes.
  • blueberry is a general term for deciduous shrub fruit trees native to North America that are classified as Cyanobacteria cyanococas section.
  • bilberries are one of the varieties of blueberries. The type is different from blueberries used for food. Further, it is generally known that the amount of anthocyanins contained is twice or more that of blueberries in bilberries.
  • bilberry extract is preferably used as an anthocyanin-containing material.
  • the anthocyanin absorption promoting composition provided by the present invention can be used to prepare various functional health foods.
  • functional health foods include beverages, tablet candy, hard candy, gummy, jelly and other desserts, yogurt, fruit sauce, syrup, water candy, capsule functional health food, etc. Can be mentioned.
  • the form may be solid or liquid as long as it has an effect.
  • the anthocyanin absorption enhancing composition of the present invention can be added to a pharmaceutical composition.
  • Examples of the anthocyanin absorption-promoting composition of the present invention include an eye strain therapeutic agent, a visual loss prevention drug, a myopia therapeutic drug, a blood flow improving drug, and an anticancer drug. It can be added to drugs, antiviral drugs, antiallergic drugs, anticholesterol drugs, antihypertensive drugs, antiarteriosclerotic drugs and the like.
  • Such a material is not particularly limited, and examples thereof include excipients, disintegrants, lubricants, binders, antioxidants, colorants, anti-aggregation agents, stabilizers, and viscosity modifiers. .
  • the excipient is not particularly limited, and examples thereof include sucrose, lactose, glucose, corn starch, mannitol, crystalline cellulose, calcium phosphate, calcium sulfate, and magnesium sulfate.
  • the disintegrant is not particularly limited, and examples thereof include starch, agar, calcium citrate, calcium carbonate, sodium hydrogen carbonate, dextrin, crystalline cellulose, carboxymethyl cellulose, tragacanth and the like.
  • Examples of the lubricant include talc, magnesium stearate, polyethylene glycol, silica, hydrogenated vegetable oil, and the like
  • examples of the binder include ethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, tragacanth, shellac, gelatin, and gum arabic.
  • Polyvinyl pyrrolidone polyvinyl alcohol, polyacrylic acid, polymethacrylic acid, sorbitol and the like.
  • antioxidant examples include ascorbic acid, tocopherol, sodium hydrogen sulfite, sodium thiosulfate, sodium pyrosulfite, citric acid and the like, and the coloring agent is permitted to be added to pharmaceuticals and foods.
  • aggregation inhibitor examples include stearic acid, talc, light anhydrous silicic acid, hydrous silicic acid dioxide and the like.
  • examples of the stabilizer include benzoic acid, sodium benzoate, ethyl paraoxybenzoate, propylene glycol, and the like, and examples of the viscosity modifier include beeswax, mole, lanolin, microcrystalline wax, liquid paraffin, and the like. Can be mentioned.
  • Bilberry extract was prepared as an anthocyanin-containing material. That is, the fruit of bilberry (Vaccinium myrtillus) was obtained by immersing it in water or an alcoholic hydrophilic organic solvent and extracting it. A commercially available product (for example, Indena) may be used.
  • Example 2 Preparation of an anthocyanin absorption promoting composition Using the bilberry extract prepared in Example 1 or a commercially available bilberry extract (manufactured by Indena), rice germ oil, flaxseed oil, perilla oil, fish oil, oleic acid, linol Acid, ⁇ -linolenic acid, ⁇ -linolenic acid, eicosapentaenoic acid, docosahexaene and the like were mixed in a conventional manner at a mixing ratio of 10: 5 to prepare the anthocyanin absorption promoting composition of the present invention.
  • the anthocyanin absorption promoting composition of the present invention was examined for in vivo absorption using a mouse. The method followed the method described in Non-Patent Document 3. ddy male mice (6 weeks old) are fasted overnight, and bilberry extract alone and bilberry extract-containing anthocyanin absorption promoting composition (as bilberry extract, dose: equivalent to 300 mg / kg body weight) are forcibly administered to mice, Before administration, the whole amount of urine excreted 8 hours after administration is collected while keeping the acidity, and the whole urine is subjected to solid phase extraction treatment according to the method described in Non-Patent Document 3 to measure the absorbance at 520 nm derived from anthocyanin, and Quantification by HPLC was performed to determine the amount of urinary excretion (mg) of anthocyanin.
  • FIG. 1 is a mixed composition of bilberry extract and edible oil, and the ordinate indicates anthocyanin excretion (mg).
  • FIG. 2 is a mixed composition of bilberry extract and unsaturated fatty acid, and the ordinate indicates anthocyanin excretion (mg).
  • Table 1 is a mixed composition of bilberry extract and unsaturated fatty acid, and the ordinate indicates anthocyanin excretion (mg).
  • Table 1 is a mixed composition of bilberry extract and unsaturated fatty acid, and the ordinate indicates anthocyanin excretion (mg).
  • Table 1 is a mixed composition of bilberry extract and unsaturated fatty acid
  • the anthocyanin absorption enhancing composition of the present invention which is a mixture with edible oil, has a higher urinary excretion and bioabsorbability than the control (test sample 1). Is understood to be improved.
  • the mixture with linseed oil (test sample 3) was excellent in its effect.
  • the mixture with unsaturated fatty acid improves the in vivo absorbability of anthocyanins compared to the control (test sample 10), and oleic acid (test sample) 11) and ⁇ -linolenic acid (test sample 14) were particularly excellent, and it was judged that unsaturated fatty acids were responsible for part of the anthocyanin absorption promoting effect by edible oil.
  • Example 3 Application to functional food (Part 1) To a mixture of 8 parts by weight of beeswax, 2 parts by weight of lecithin, 18 parts by weight of diglycerin monooleate, 70 parts by weight of the anthocyanin absorption promoting composition of the present invention, 1 part by weight of astaxanthin and 1 part by weight of vitamin A are added and mixed. A soft capsule for eating and drinking was obtained by press-fitting into the gelatin film using a rotary type soft capsule manufacturing apparatus.
  • Example 4 Application to functional food (Part 2) After 6 parts by weight of the anthocyanin absorption promoting composition of the present invention is adsorbed on 40 parts by weight of microcrystalline cellulose, 20 parts by weight of corn starch, 8 parts by weight of lactose, 8 parts by weight of carboxymethyl cellulose and 2 parts by weight of magnesium stearate are added thereto. Next, 8 parts by weight of an aqueous solution of polyvinylpyrrolidone was added and granulated. To this was added 8 parts by weight of talc as a lubricant and mixed, and then tableted into tablets to obtain tablet candy.
  • an anthocyanin absorption promoting composition with improved in vivo absorbability is provided for anthocyanins with low in vivo absorbability so far, which will assist in the development of functional foods in the future. Is.

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Abstract

La présente invention concerne une composition contenant de l'anthocyane qui accroît la bioabsorbabilité des anthocyanes, qui présentent une faible biodisponibilité, améliore l'absorption efficace in vivo des anthocyanes dans le corps afin d'engendrer une bioactivité adéquate avec un dosage inférieur d'anthocyanes. Une composition favorisant l'absorption d'anthocyane obtenue en mélangeant à la fois un matériau contenant de l'anthocyane et un acide gras insaturé en C14 ou plus ou au moins un type d'huile alimentaire contenant l'acide gras insaturé, l'acide gras insaturé en C14 ou plus étant sélectionné parmi l'acide myristoléique, l'acide palmitoléique, l'acide oléique, l'acide linoléique, l'acide linolénique, l'acide eicosapentaénoïque, et l'acide docosahexaénoïque, et l'huile alimentaire est sélectionné parmi l'huile de germe de riz, l'huile de lin, l'huile de périlla et l'huile de poisson.
PCT/JP2012/082536 2012-02-24 2012-12-14 Composition favorisant l'absorption d'anthocyane WO2013125135A1 (fr)

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JP2012-038603 2012-02-24

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016182070A (ja) * 2015-03-26 2016-10-20 日清食品ホールディングス株式会社 黒ゴマの製造方法
EP3509437A4 (fr) * 2016-09-07 2020-04-22 Nanosmart Fruit, LLC Compositions comprenant des nanoparticules dérivées de fruit entier
WO2021197971A1 (fr) * 2020-04-01 2021-10-07 Evonik Operations Gmbh Préparation destinée à être utilisée en tant qu'antioxydant

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JPH0640928A (ja) * 1992-05-11 1994-02-15 Idb Holding Spa アントシアノシド類を含有する経口医薬組成物
JP2000032954A (ja) * 1998-07-17 2000-02-02 Gosho:Kk アントシアニン系赤米抽出液・粉末とその製造法
JP2005287376A (ja) * 2004-03-31 2005-10-20 Q P Corp 眼精疲労用飲食品組成物
JP2008500027A (ja) * 2004-05-03 2008-01-10 ノーザン ライツ フード プロセシング，エルエルシー ベリーオイルおよび製品
JP2008035714A (ja) * 2006-08-01 2008-02-21 Wakasa Seikatsu:Kk 健康食品
JP2009046438A (ja) * 2007-08-21 2009-03-05 Api Co Ltd アントシアニン含有組成物及びその製造方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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