WO2013038949A1 - Composition anti-allergène - Google Patents

Composition anti-allergène Download PDF

Info

Publication number
WO2013038949A1
WO2013038949A1 PCT/JP2012/072436 JP2012072436W WO2013038949A1 WO 2013038949 A1 WO2013038949 A1 WO 2013038949A1 JP 2012072436 W JP2012072436 W JP 2012072436W WO 2013038949 A1 WO2013038949 A1 WO 2013038949A1
Authority
WO
WIPO (PCT)
Prior art keywords
allergen
tungsten oxide
processed
allergen composition
allergenicity
Prior art date
Application number
PCT/JP2012/072436
Other languages
English (en)
Japanese (ja)
Inventor
圭一郎 乾
酒谷　能彰
Original Assignee
住化エンビロサイエンス株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 住化エンビロサイエンス株式会社 filed Critical 住化エンビロサイエンス株式会社
Publication of WO2013038949A1 publication Critical patent/WO2013038949A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/16—Antifouling paints; Underwater paints
    • C09D5/1606—Antifouling paints; Underwater paints characterised by the anti-fouling agent
    • C09D5/1612—Non-macromolecular compounds
    • C09D5/1618—Non-macromolecular compounds inorganic
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
    • D06M11/32—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/36—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxides; with salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/48—Oxides or hydroxides of chromium, molybdenum or tungsten; Chromates; Dichromates; Molybdates; Tungstates
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M23/00—Treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, characterised by the process
    • D06M23/08—Processes in which the treating agent is applied in powder or granular form

Definitions

  • the present invention relates to an anti-allergen composition that reduces allergenicity of allergens such as mites and pollen, and paints, coating agents, resin products, wallpaper, nonwoven fabrics, fibers or textile products using the same, and life using them
  • the present invention relates to a method for reducing allergenicity of allergen substances in the environment.
  • Allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis are plagued by many people, and in recent years, the tendency has been increasing.
  • the causes of these allergic diseases are various allergens present in the environment. Among them, mites, pet hair, pollen, and mold that inhabit indoors are typical inhalable allergens. Well known.
  • leopard mites which are dust mites that live in the house, are a major problem as an allergen source.
  • Lion mites become a hotbed for growing textile products in the house such as tatami mats, carpets, bedding, curtains, etc., or seat sheet fabrics of moving vehicles such as trains and cars outdoors.
  • pollen of various plants including cedar (Cryptomeria japonica) pollen scattered in early spring is an allergen, and causes allergic rhinitis in particular.
  • the pollen that scatters is not only cedar pollen in the early spring, but also many kinds of cypress, mugwort, ragweed, camo, etc.
  • cedar pollen scattered in the early spring, but also many kinds of cypress, mugwort, ragweed, camo, etc.
  • There is a state that some kind of pollen is scattered throughout the year, and there is a risk of causing pollen allergies at any time It is thought that there is.
  • the mask is used to prevent inhalation of cedar pollen, but the pollen attached to the mask does not lose allergenicity, so there is a risk that it will be absorbed by re-scattering. .
  • a vacuum cleaner is effective as a method for removing allergens, but a large amount of allergens contained in the sucked garbage is only stored in the dust bag, and there is a risk that the allergen will re-scatter when the dust bag is discarded. Conceivable.
  • tannic acid As a drug for reducing or eliminating allergenicity of allergen substances, tannic acid has been known for a long time, and a method of applying tannic acid has been proposed.
  • tannic acid has a brown color and further has a disadvantage that its use is limited by the progress of coloring over time.
  • various proposals have been made as anti-allergen agents that hardly cause coloring or discoloration. For example, methods using inorganic salts such as zinc and magnesium have been proposed (Patent Documents 1 and 6).
  • these anti-allergen agents are not water-soluble, but when processed using a resin emulsion such as an acrylic emulsion as a binder on non-woven fabrics, fibers, fiber products, plastic products, and wood materials (Patent Document 7), the amount of the binder is low. When it is sufficient, the anti-allergen agent is covered to prevent runoff, but the antiallergen performance itself is not exhibited. If the amount of the binder is small, the runoff cannot be prevented and the effect cannot often be maintained.
  • a resin emulsion such as an acrylic emulsion as a binder on non-woven fabrics, fibers, fiber products, plastic products, and wood materials
  • Patent Documents 3, 4, 5, 7, and 8 those using a photocatalyst such as titanium oxide as an anti-allergen agent have been proposed. There is a risk that the processed substrate itself may deteriorate.
  • the anti-allergen agent is easily washed away (washed out or dropped out) with water, the washing resistance is not sufficient when processed into a fiber or the like.
  • the anti-allergen agent cannot be used in applications that require these functions.
  • the problem of the present invention is to solve the above-mentioned problems of the background art, and to provide an anti-allergen composition that reduces allergenicity of allergen substances such as mites and pollen, and further processed with the anti-allergen composition, Anti-allergenic processed products such as fibers or textile products should retain durability without losing the function of reducing allergenicity even when washed with water, and will not cause coloring or discoloration. It is to be able to efficiently reduce the allergenicity of allergenic substances present in the environment using a product.
  • fine-particle tungsten oxide having an average particle diameter of 5 ⁇ m or less exhibits an excellent effect as an antiallergen agent. Further, the present inventors have found that it is also effective as an antiallergen having water resistance.
  • the present invention is (1) an anti-allergen composition characterized by containing a particulate tungsten oxide having an average particle diameter of 5 ⁇ m or less (preferably 0.01 ⁇ m or more), and (2) tungsten oxide is An anti-allergen composition which is tungsten oxide supporting a transition metal, and (3) an anti-allergen composition wherein the transition metal supported is one or more metals selected from platinum, copper, zinc, nickel and cobalt.
  • the allergen reduction method reduces the allergenicity of allergen substances in the environment.
  • the present invention provides an anti-allergen composition that reduces the allergenicity of allergen substances such as mites and pollen by using an anti-allergen composition characterized by containing tungsten oxide having a predetermined particle size.
  • Non-allergenic processed products such as non-woven fabrics, fibers or fiber products processed with the composition are maintained with good durability without losing the function of reducing allergenicity even when washed with water, and further, do not cause coloring or discoloration, Moreover, there exists an advantage that the allergenicity of the allergenic substance which exists in an environment can be efficiently reduced using processed products, such as these compositions, a filter, and a mask.
  • the fine particulate tungsten oxide used in the present invention can be a fine powder of tungsten oxide available as an industrial raw material. If such tungsten oxide powder is dispersed in water or a solvent, it can be used in various applications. Easy to use. When dispersing, a surfactant or the like as a dispersant can be appropriately added.
  • the metal that is to be supported on tungsten oxide is mixed.
  • it can be obtained by mixing a metal salt to be supported on a compound to be a precursor of tungsten oxide, forming or applying the mixture as necessary, and then firing or irradiating light. .
  • tungsten oxide supporting platinum when preparing tungsten oxide supporting platinum, it is preferable that zero-valent platinum is supported, and metallic platinum can be mixed.
  • a divalent or tetravalent platinum compound is combined with an organic substance.
  • a tungsten oxide carrying platinum is obtained by mixing with a precursor of tungsten oxide and firing it or irradiating it with light.
  • tungsten oxide precursor examples include tungstate, and various tungstates can be used. Examples thereof include tungstates such as sodium tungstate, potassium tungstate, and ammonium tungstate.
  • divalent and tetravalent platinum compounds described above include, but are not limited to, dichlorodiammine platinum (II), dinitroammine platinum (II), tetraammine platinum (II) chloride, platinum chloride (II), tetrachloroplatinum ( II) Potassium acid, hexachloroplatinum (IV) acid and the like can be used.
  • platinum compounds may be used in combination of two or more.
  • organic substance to be mixed to reduce the metal salt there is no particular limitation on the organic substance to be mixed to reduce the metal salt, but carbon materials such as graphite, polyethylene, polypropylene, polymethyl methacrylate, polycarbonate, polystyrene, polyacrylic acid ester, polyimide, epoxy resin, starch Etc. can be used. These organic substances may be used in combination of two or more.
  • the amount of the metal to be supported is suitably 3.0 parts by mass or less, preferably 1.0 parts by mass or less with respect to 100 parts by mass of tungsten oxide.
  • amount of the metal to be supported exceeds 3 parts by mass, an efficient improvement of the antiallergen effect cannot be expected, and practicality is lost in view of the cost and amount of the metal to be supported.
  • metals can be used as the metal to be supported, and examples include transition metals such as copper, zinc, cobalt, nickel, palladium, ruthenium, rhodium, platinum, silver, gold, iridium, and among these, platinum, copper Gold is preferred.
  • transition metals such as copper, zinc, cobalt, nickel, palladium, ruthenium, rhodium, platinum, silver, gold, iridium, and among these, platinum, copper Gold is preferred.
  • transition metals such as copper, zinc, cobalt, nickel, palladium, ruthenium, rhodium, platinum, silver, gold, iridium, and among these, platinum, copper Gold is preferred.
  • transition metals such as copper, zinc, cobalt, nickel, palladium, ruthenium, rhodium, platinum, silver, gold, iridium, and among these, platinum, copper Gold is preferred.
  • These metals can be used in the form of fine particles, oxides, hydroxides, nit
  • a firing apparatus such as an airflow firing furnace, a tunnel furnace, or a rotary furnace can be used.
  • the firing temperature is set in the range of 350 to 750 ° C., preferably in the range of 400 to 550 ° C.
  • the firing time may be appropriately set according to the firing temperature and the type of firing apparatus, but is usually set in the range of 10 minutes to 30 hours, preferably in the range of 30 minutes to 10 hours.
  • the particle diameter of tungsten oxide or tungsten oxide supporting a metal according to the present invention has a higher allergen reducing effect when the average particle diameter is 5 ⁇ m or less.
  • the lower limit of the average particle diameter of tungsten oxide is not particularly recognized from the operational effects of the present invention, but the average particle diameter is preferably 0.01 ⁇ m or more from a practical viewpoint, more preferably. Is 0.03 ⁇ m or more.
  • the average particle size shows a value of 25 ⁇ m or more, but the particle size can be reduced by performing wet grinding using glass beads or zirconia beads. .
  • the average particle size of the ground tungsten oxide or the tungsten oxide supporting the metal needs to be 5 ⁇ m or less, preferably 3 ⁇ m or less, more preferably 1 ⁇ m or less, and still more preferably 0.5 ⁇ m or less. To do.
  • a laser diffraction particle size distribution measuring device In order to measure the average particle size, a laser diffraction particle size distribution measuring device can be used. In Examples described later, a laser diffraction particle size distribution measuring device SALD-2200 manufactured by Shimadzu Corporation is used, and the average particle size is measured. The median diameter was used as the value of. However, other particle size distribution measuring devices such as a centrifugal sedimentation type particle size distribution measuring device can also be used. In this case, it is preferable to keep a correlation with the laser diffraction type particle size distribution measuring device.
  • the measured value of the average particle diameter may differ depending on the difference in equipment manufacturer and the wavelength distribution of the laser light source, and it is preferable to keep correlation between various instruments. .
  • Tungsten oxide and especially tungsten oxide supporting transition metal show the performance as a photocatalyst, but the performance as an anti-allergen agent of the present invention does not necessarily require the presence of light, and the allergen reduction effect even in the dark Demonstrate.
  • tungsten oxide does not dissolve in water or an organic solvent
  • a flowable agent is suitable for formulation.
  • the flowable agent it is possible to wet pulverize tungsten oxide together with a dispersant.
  • a flowable agent it is usually advantageous to prepare a formulation based on water, but it is also possible to prepare a flowable agent based on a solvent other than water.
  • the content of tungsten oxide in the anti-allergen composition such as a flowable agent can be adjusted in the range of 0.01 to 60%, preferably 0.1 to 50%, more preferably 1 to 30%. If it exceeds 60%, the fluidity of the agent will decrease, and if it is less than 0.01%, the amount of active ingredients will decrease and appropriate processing will be difficult.
  • the solvent used in the anti-allergen composition is not particularly limited, but both nonpolar solvents and polar solvents can be used.
  • examples of such solvents are ethanol, propyl alcohol, isopropyl alcohol, butanol, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, N-methylpyrrolidone, ⁇ -butyrolactone, dimethyl sulfoxide, ethylene glycol, propylene glycol.
  • Butylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol (molecular weight 1000 or less), polypropylene glycol (molecular weight 1000 or less), ethyl acetate, butyl acetate, kerosene, alkylbenzene, diethylhexyl phthalate, diethyl phthalate, dioctyl phthalate, fluid Paraffin etc. are mentioned. These solvents may be used in combination of two or more.
  • an anionic surfactant or a nonionic surfactant, or a combination thereof is usually used, but a cationic surfactant or an amphoteric surfactant may be used.
  • the type of the surfactant is not particularly limited, but examples of the nonionic surfactant include polyoxyethylene alkyl phenyl ether, polyoxyethylene styryl phenyl ether, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, sorbitan fatty acid ester, Examples include polyoxyethylene sorbitan fatty acid esters.
  • anionic surfactant examples include alkyl benzene sulfonate, polyoxyethylene alkyl phenyl ether sulfate, and dialkyl sulfosuccinate.
  • Cationic surfactants include aliphatic amine salts and quaternary ammonium salts, and amphoteric surfactants include betaine surfactants and aminocarboxylates. Further, these nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants may be used alone or in combination of two or more.
  • anti-allergen component it is possible to further add a known anti-allergen component to the anti-allergen composition of the present invention.
  • anti-allergen components include hydroxybenzoic acid compounds such as 2,5-dihydroxybenzoic acid, 2,6-dihydroxybenzoic acid, 2,4,6-trihydroxybenzoic acid, salts thereof, and persimmons. Can be mentioned.
  • the anti-allergen composition of the present invention When used for the purpose of removing allergens from indoor dust mites, the anti-allergen effect can be further maintained by adding an acaricide and processing it.
  • the acaricide used is not particularly limited as long as it has a lethal and repellent effect on indoor dust mites.
  • pyrethroid compounds such as natural pyrethrin, phenothrin, and permethrin
  • organophosphorus compounds such as fenitrothion, malathion, fenthion, and diazinon, dicofol, chlorbenzilate, hexityazox, tebufenpyrad, pyridaben, and amidoflumet are used. be able to.
  • the anti-allergen composition of the present invention can be used after being processed by a method such as dipping, coating, spraying, etc. on a nonwoven fabric, fiber or fiber product.
  • Textiles or textile products include clothing, carpets, sofas, wallpaper, curtains and other interior items, futon sides, futon covers, futon batting, sheets, pillowcases, mats and other bedding, car seats, car mats, and ceiling materials
  • automobile parts such as flooring, stuffed animals, etc.
  • non-woven fabrics include wet wipers for cleaning, masks, filter materials, and dust collection bags for vacuum cleaners.
  • non-woven fabrics and fibers that can process the anti-allergen composition of the present invention.
  • nylon, cotton, polyester, wool and the like are used, and composite fibers using two or more kinds of these fibers. There is no problem.
  • it can be used also for the nonwoven fabric using polyethylene and a polypropylene.
  • the method for processing the anti-allergen composition of the present invention into a non-woven fabric, fiber or fiber product is not particularly limited, and immersion treatment, spray treatment, exhaustion processing, and the like can be performed.
  • the amount of processing into fibers is 0.01 to 10 g / m 2 , preferably 0.05 to 2 g / m 2 as tungsten oxide or tungsten oxide supporting a metal with respect to the weight of the nonwoven fabric, fiber or fiber product. More preferably, it is 0.1 to 1 g / m 2 .
  • a binder may be used in combination in order to further improve washing durability.
  • a binder any type of resin emulsion such as acrylic or urethane can be used.
  • the urethane binder may be any type such as an ester type, an ether type, and a polycarbonate type, and may be anionic, anionic, cationic, or nonionic.
  • the concentration of the binder to be used is not particularly limited, but the amount of the resin to be blended is desirably equal to or less than the equivalent amount of tungsten oxide.
  • the amount of the binder used is too large, the anti-allergen agent is covered and the effectiveness is hardly exhibited.
  • anti-allergen composition of the present invention in addition to the aforementioned surfactant and anti-mite agent, as necessary, chelating agent, anti-rust agent, antibacterial agent, perfume, scale inhibitor, antifoaming agent, It is also possible to add an antistatic agent, a thickener, a softening agent and the like.
  • compositions that may come into contact with people in the living environment such as softeners, deodorants, fungicides, disinfectants, insecticides, etc. It is also possible to reduce allergens in the living environment by adding to paints, adhesives, etc., and materials that humans may come into contact with in the living environment, such as wood, wooden materials, plywood, concrete, It is also possible to reduce allergens in the living environment by processing into building materials such as metal, stone, glass, etc., molded articles made of rubber, paper, resin, plastic, and the like.
  • allergens derived from mites in house dust, pet hair and epithelium such as dogs and cats, cockroaches, feathers, Allergens derived from fungi and pollen such as cedar, mugwort, hargaya, cypress, ragweed, and natural rubber latex can be reduced, and various allergens can be substantially eliminated. Therefore, the present invention works particularly effectively when the allergen in the human living environment is a mite allergen or a plant allergen in house dust.
  • Example 1 30 g of tungsten oxide (manufactured by Wako Pure Chemical Industries, Ltd.), 1 g of an anionic surfactant (manufactured by Kao Corporation: Poise 520) and 69 g of water are mixed, and wet grinding is performed using glass beads having a diameter of 1 mm for 15 minutes. The glass beads were removed with a 30 mesh wire mesh. This dispersion was diluted 3 times with ion-exchanged water to obtain a 10% tungsten oxide dispersion. It was 0.4 micrometer when the average particle diameter of the tungsten oxide was measured with the laser diffraction type particle size distribution measuring apparatus (Shimadzu Corporation make: SALD2200).
  • Example 2 30 g of tungsten oxide (manufactured by Wako Pure Chemical Industries, Ltd.), 1 g of an anionic surfactant (manufactured by Kao Corporation: Poise 520) and 69 g of water are mixed, and wet pulverization is performed using glass beads having a diameter of 1 mm for 2 minutes. The glass beads were removed with a 30 mesh wire mesh. This dispersion was diluted 3 times with ion-exchanged water to obtain a 10% tungsten oxide dispersion. It was 5.0 micrometers when the average particle diameter of the tungsten oxide was measured with the laser diffraction type particle size distribution measuring apparatus.
  • Example 3 According to the method described in Example 1 of WO 11/068095, a dispersion of 10% tungsten oxide supporting platinum was obtained. It was 0.4 micrometer when the average particle diameter of the obtained tungsten oxide was measured with the laser diffraction type particle size distribution measuring apparatus.
  • Examples 1 to 3 and Comparative Examples 1 to 3 are each 10 times with ion-exchanged water for 1 mL of mite allergen Der f2 about 900 ng / mL ⁇ phosphate buffer solution (pH 7.2) ⁇ contained in standard house dust. The diluted solution and 50 ⁇ L of distilled water as a control were reacted in the dark. These samples were measured for the mite allergen reducing effect by the sandwich method of Der f2 enzyme immunoassay (ELISA).
  • ELISA enzyme immunoassay
  • Cry j1 monoclonal antibody 013 diluted to 2 ⁇ g / mL with phosphate buffer (pH 7.4, containing 0.1% by mass NaN 3 ) was added per well of F16 MAXISORP NUNC-IMMUNO MODULE plate (manufactured by NUNC). 100 ⁇ L each was added and sensitized at 4 ° C. for 1 day or longer. After sensitization, the solution was discarded, and a blocking reagent ⁇ 1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 ) ⁇ was added in an amount of 200 ⁇ L per well. Reacted for 1 minute. After the reaction, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate).
  • phosphate buffer pH 7.4, containing 0.1% by mass NaN 3
  • the extract obtained by reacting the cedar pollen allergen and the above composition was added dropwise at 100 ⁇ L per well and reacted at 37 ° C. for 60 minutes.
  • the plate was washed with a phosphate buffer (pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate).
  • Peroxidase-labeled Cry j1 monoclonal antibody 053 was dissolved in distilled water at 200 ⁇ g / mL, and was dissolved in phosphate buffer ⁇ pH 7.2, 1% by weight bovine serum albumin and 0.1% by weight polyoxyethylene (20) sorbitan mono
  • a solution diluted 1200 times with laurate contained ⁇ was added at 100 ⁇ L per well.
  • the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 mass% polyoxyethylene (20) sorbitan monolaurate).
  • Der f2 monoclonal antibody 15E11 diluted to 2 ⁇ g / mL with a phosphate buffer (pH 7.4, containing 0.1 mass% NaN 3 ) was added to each well of F16 MAXISORP NUNC-IMMUNO MODULE plate (manufactured by NUNC). 200 ⁇ L each was added and sensitized at 4 ° C. for 3 days or more. After sensitization, the solution was discarded, and a blocking reagent ⁇ 1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 ) ⁇ was added in an amount of 200 ⁇ L per well. Reacted for 1 minute.
  • a blocking reagent ⁇ 1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 ) ⁇ was added in an amount of 200 ⁇ L per well. Reacted for 1 minute.
  • the plate was washed with a phosphate buffer (pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate).
  • a phosphate buffer pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate.
  • a phosphate buffer pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate.
  • the peroxidase-labeled Der f2 monoclonal antibody was dissolved in distilled water at 200 ⁇ g / mL, and was dissolved in phosphate buffer ⁇ pH 7.2, 1% by weight bovine serum albumin and 0.1% by weight polyoxyethylene (20) sorbitan monolaur.
  • a solution diluted 1000 times with a rate containing ⁇ was added at 100 ⁇ L per well. After reacting at 37 ° C.
  • the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 mass% polyoxyethylene (20) sorbitan monolaurate) and then with distilled water. 100 ⁇ L per well of 13 mL of 0.1 mol / L phosphate buffer (pH 6.2) plus ortho-phenylenediamine dihydrochloride (26 mg Table, manufactured by SIGMA CHEMICAL CO.) And 13 ⁇ L of 30% hydrogen peroxide solution The mixture was added and reacted at 37 ° C. for 5 minutes.
  • a phosphate buffer pH 7.2, containing 0.1 mass% polyoxyethylene (20) sorbitan monolaurate
  • the mite allergen reduction rate of Examples 1 and 2 maintains a relatively high value even after washing with water, and the anti-allergen composition reduces allergenicity even when washed with water. It can be seen that it is retained with good durability without losing the function to make it. Further, in Comparative Example 1 using tungsten oxide having a large particle size of 28 ⁇ m, the reduction rate of mite allergen was low from the beginning, and the same result was obtained after washing with water.
  • Cry j1 monoclonal antibody 013 diluted to 2 ⁇ g / mL with phosphate buffer (pH 7.4, containing 0.1% by mass NaN 3 ) was added per well of F16 MAXISORP NUNC-IMMUNO MODULE plate (manufactured by NUNC). 100 ⁇ L each was added and sensitized at 4 ° C. for 1 day or longer. After sensitization, the solution was discarded, and a blocking reagent ⁇ 1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 ) ⁇ was added in an amount of 200 ⁇ L per well. Reacted for 1 minute.
  • the plate was washed with a phosphate buffer (pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate).
  • a phosphate buffer pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate.
  • 100 ⁇ L of a cedar pollen allergen extract solution contacted with the processed non-woven fabric was added dropwise per well and reacted at 37 ° C. for 60 minutes.
  • a phosphate buffer pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate.
  • Peroxidase-labeled Cry j1 monoclonal antibody 053 was dissolved in distilled water at 200 ⁇ g / mL, and the solution was dissolved in phosphate buffer ⁇ pH 7.2, 1% by weight bovine serum albumin and 0.1% by weight polyoxyethylene (20) sorbitan mono
  • a solution diluted 1200 times with laurate contained ⁇ was added at 100 ⁇ L per well. After reacting at 37 ° C.
  • phosphate buffer pH 7.2, containing 0.1 mass% polyoxyethylene (20) sorbitan monolaurate.
  • 100 ⁇ L per well of 13 mL of 0.1 mol / L phosphate buffer (pH 6.2) plus ortho-phenylenediamine dihydrochloride (26 mg Table, manufactured by SIGMA CHEMICAL CO.) And 13 ⁇ L of 30% hydrogen peroxide solution The mixture was added and reacted at 37 ° C. for 5 minutes.
  • the cedar pollen allergen reduction rate of Examples 1 and 2 maintains a relatively high value even after washing with water, and the anti-allergen composition exhibits allergenicity even when washed with water. It can be seen that durability is maintained without losing the function of reducing.
  • Comparative Example 1 using tungsten oxide having a large particle size of 28 ⁇ m the reduction rate of cedar pollen allergen was initially 13%, but it was almost lost after washing, and the effect was lost by washing. I understand that.
  • a non-woven fabric (20 cm ⁇ 20 cm) of 80 g / m 2 was immersed in 50 g of a solution obtained by diluting Example 3 65 times or 130 times with ion-exchanged water for 1 minute, treated at a squeeze rate of 160%, and then at 110 ° C. for 10 minutes. It was dried (the processing amount was about 1 g / m 2 or about 2 g / m 2 ).
  • the nonwoven fabric processed in this way was cut into two pieces, one was immersed in 4 L of ion exchange water, stirred for 30 minutes, taken out, air-dried at room temperature, and used as a sample after washing with water.
  • Der f2 monoclonal antibody 15E11 diluted to 2 ⁇ g / mL with a phosphate buffer (pH 7.4, containing 0.1 mass% NaN 3 ) was added to each well of F16 MAXISORP NUNC-IMMUNO MODULE plate (manufactured by NUNC). 200 ⁇ L each was added and sensitized at 4 ° C. for 3 days or more. After sensitization, the solution was discarded, and a blocking reagent ⁇ 1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 ) ⁇ was added in an amount of 200 ⁇ L per well. Reacted for 1 minute.
  • a blocking reagent ⁇ 1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 ) ⁇ was added in an amount of 200 ⁇ L per well. Reacted for 1 minute.
  • the plate was washed with a phosphate buffer (pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate).
  • a phosphate buffer pH 7.2, containing 0.1% by mass polyoxyethylene (20) sorbitan monolaurate.
  • the peroxidase-labeled Der f2 monoclonal antibody was dissolved in distilled water at 200 ⁇ g / mL, and was dissolved in phosphate buffer ⁇ pH 7.2, 1% by weight bovine serum albumin and 0.1% by weight polyoxyethylene (20) sorbitan monolaur. A solution diluted 1000 times with a rate containing ⁇ was added at 100 ⁇ L per well. After reacting at 37 ° C. for 60 minutes, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 mass% polyoxyethylene (20) sorbitan monolaurate) and then with distilled water.
  • phosphate buffer pH 7.2, containing 0.1 mass% polyoxyethylene (20) sorbitan monolaurate
  • Example 3 using the anti-allergen composition using tungsten-supported platinum, the allergen reduction effect was activated by light irradiation, and the reduction rate was increased.
  • Example 3 had the allergen reduction effect which endures use even if it is not irradiated with light.
  • the allergen reduction effect is not changed before and after washing with or without light irradiation, and even if washed with water, the allergen reduction effect is maintained with good durability without losing the function of reducing allergenicity.
  • the allergenicity of allergenic substances such as mites and pollen can be reduced, and the antiallergen for imparting a function of reducing the allergenicity of a nonwoven fabric, fiber or textile product with durability to washing.
  • Compositions and paints, plastic products, vinyl chloride wallpaper, nonwoven fabrics, fibers or textiles that can reduce allergens can be provided.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Paints Or Removers (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

Abstract

La présente invention concerne une composition anti-allergène pour réduire l'allergénicité d'une substance allergène telle que les acariens ou le pollen, et rend possible d'amener un produit traité anti-allergénique tel qu'un tissu non tissé, un textile ou un produit textile, traité avec la composition anti-allergène à conserver une durabilité favorable et à ne pas éprouver de coloration ou de changement de couleur, sans perte de fonction pour réduire l'allergénicité, même lors d'un lavage avec de l'eau, et rend également possible d'utiliser de telles compositions et produits traités pour réduire de façon efficace l'allergénicité d'une substance allergénique présente dans l'environnement. La composition anti-allergène contient de l'oxyde de tungstène micro-particulaire ayant un diamètre moyen de particule de 5 µm ou moins. L'oxyde de tungstène peut être de l'oxyde de tungstène supportant un métal de transition tel que le platine, le cuivre, le zinc, le nickel ou le cobalt, et la composition anti-allergène d'une telle description est traitée pour fabriquer une peinture, un agent de revêtement, un produit de type résine, un papier peint, un tissu non tissé, un textile ou un produit textile. L'invention concerne également un procédé de réduction de l'allergénicité d'une substance allergène et qui comprend l'utilisation de cette composition dans un environnement vivant de personnes.
PCT/JP2012/072436 2011-09-16 2012-09-04 Composition anti-allergène WO2013038949A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011203229A JP5927625B2 (ja) 2011-09-16 2011-09-16 抗アレルゲン組成物
JP2011-203229 2011-09-16

Publications (1)

Publication Number Publication Date
WO2013038949A1 true WO2013038949A1 (fr) 2013-03-21

Family

ID=47883180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2012/072436 WO2013038949A1 (fr) 2011-09-16 2012-09-04 Composition anti-allergène

Country Status (2)

Country Link
JP (1) JP5927625B2 (fr)
WO (1) WO2013038949A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006241431A (ja) * 2004-10-29 2006-09-14 Toyobo Co Ltd アレルゲン不活化剤およびそれを用いたフィルタ
JP2011111600A (ja) * 2009-11-30 2011-06-09 Panasonic Electric Works Co Ltd 可視光応答型光触媒コーティング材、コーティング処理物及びアレルゲン不活性化方法
JP2011132626A (ja) * 2009-12-24 2011-07-07 Sumitomo Chemical Co Ltd 光触媒体担持繊維製品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006241431A (ja) * 2004-10-29 2006-09-14 Toyobo Co Ltd アレルゲン不活化剤およびそれを用いたフィルタ
JP2011111600A (ja) * 2009-11-30 2011-06-09 Panasonic Electric Works Co Ltd 可視光応答型光触媒コーティング材、コーティング処理物及びアレルゲン不活性化方法
JP2011132626A (ja) * 2009-12-24 2011-07-07 Sumitomo Chemical Co Ltd 光触媒体担持繊維製品

Also Published As

Publication number Publication date
JP5927625B2 (ja) 2016-06-01
JP2013064058A (ja) 2013-04-11

Similar Documents

Publication Publication Date Title
JP5850484B2 (ja) 抗アレルゲン組成物
JP5099380B2 (ja) 抗アレルゲン剤
JP5434192B2 (ja) 抗アレルゲン性組成物および抗アレルゲン性製品
JP6906257B2 (ja) アレルゲン低減化組成物およびアレルゲン低減化方法
JP5959041B2 (ja) アレルゲン低減化機能を付与する方法
KR20080005510A (ko) 알레르겐 실활제
JP2011256283A (ja) 抗アレルゲン組成物
JP2002326944A (ja) 抗アレルゲン組成物及びアレルゲン不活性化方法
JP4968899B2 (ja) 抗アレルゲン組成物
JP2017075420A (ja) 繊維用アレルゲン低減化組成物
WO2015141712A1 (fr) Composition de réduction d'allergènes, agent à pulvériser et agent de traitement de surface la contenant et procédé de réduction d'allergènes
JP2010116450A (ja) 抗アレルゲン組成物
JP5927625B2 (ja) 抗アレルゲン組成物
JP7048960B2 (ja) アレルゲン低減化組成物
JP5467636B2 (ja) 抗アレルゲン組成物
JP2020164604A (ja) アレルゲン低減化組成物
JP2012107253A (ja) アレルゲン失活剤
JP4780648B2 (ja) 抗アレルゲン組成物
JP7255931B2 (ja) アレルゲン低減化組成物
JP2006193624A (ja) 抗アレルゲン組成物
JP6969776B2 (ja) アレルゲン低減化組成物
JP2018012799A (ja) アレルゲン低減化組成物
JP2006241432A (ja) アレルゲン不活化剤
JP6717772B2 (ja) 抗アレルゲン組成物及び該組成物によって処理された繊維・不織布又は繊維・不織布製品
JP2021134239A (ja) アレルゲン低減化組成物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12831953

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12831953

Country of ref document: EP

Kind code of ref document: A1