Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/38—Cationic compounds
  • C11D1/42—Amino alcohols or amino ethers
  • C11D1/44—Ethers of polyoxyalkylenes with amino alcohols; Condensation products of epoxyalkanes with amines
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/72—Ethers of polyoxyalkylene glycols
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D10/00—Compositions of detergents, not provided for by one single preceding group
  • C11D10/04—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap
  • C11D10/045—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap based on non-ionic surface-active compounds and soap
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/20—Organic compounds containing oxygen
  • C11D3/2075—Carboxylic acids-salts thereof
  • C11D3/2079—Monocarboxylic acids-salts thereof
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

• the invention relates to antimicrobial compositions including carboxylic acids, such as fatty acid antimicrobial agents, and a non-ionic surfactant, such as an ethoxylated amine.
• carboxylic acids such as fatty acid antimicrobial agents
• non-ionic surfactant such as an ethoxylated amine.
• the compositions can be used to clean surfaces, including for example, a solid shower cleaner and disinfectant composition and methods of use thereof.
• the present invention relates to antimicrobial compositions comprising, consisting of and/or consisting essentially of a fatty acid antimicrobial agent and an ethoxylated amine surfactant or coupling agent, and to methods of using such antimicrobial compositions.
• An advantage of the invention provides a compatible coupler for saturated fatty acids, such as decanoic acid, in an aqueous solvent.
• Compositions according to the invention provide a solid, high bio-based, cost- effective, non-irritating and non-corrosive antimicrobial cleaner, which may be used to provide a stable aqueous use solution.
• the invention comprises a composition having from about 0.05 wt-% to about 10 wt-% fatty acid antimicrobial agent and from about 0.15 wt-% to about 55 wt-% ethoxylated amine of one of the following formulas: or
• a method of reducing a microbial population on an object comprises contacting the object with a composition comprising:
• compositions and methods of the invention are especially useful as antimicrobial compositions for use as sterilants, sanitizers, disinfectants, soap scum remover, lime remover, delimer, hand wash and sanitizer and other cleaners.
• the compositions and methods have particular utility as a shower cleaner, disinfectant and sanitizer.
• the antimicrobial compositions and methods have further utility in a variety of healthcare and food service applications.
• compositions according to the invention provide many advantages over conventional cleaning products.
• compositions according to the invention provide a solid, highly bio-based, cost-effective, shower cleaner and disinfectant that is both non-irritating and non- corrosive.
• the present invention provides these numerous advantages along with demonstrating improved efficacy against Staphylococcus aureus and other bacteria.
• the compositions of the invention When applied to microbes ⁇ e.g. , when applied to a surface containing microbes), the compositions of the invention exhibit antimicrobial action. The mechanism by which such action takes place is not completely understood. However, as shown in the Examples set out below, very rapid and substantially complete antimicrobial action is attained according to the compositions and methods according to the invention.
• the term "about,” as used herein, refers to variation in the numerical quantity that can occur, for example, through typical measuring and liquid handling procedures used for making concentrates or use solutions in the real world; through inadvertent error in these procedures; through differences in the manufacture, source, or purity of the ingredients used to make the compositions or carry out the methods; and the like.
• the term “about” also encompasses amounts that differ due to different equilibrium conditions for a composition resulting from a particular initial mixture. Whether or not modified by the term “about”, the claims include equivalents to the quantities refers to variation in the numerical quantity that can occur.
• antimicrobial composition refers to a composition having the ability to cause greater than a 90% reduction (1-log order reduction) in the population of bacteria or spores.
• the antimicrobial compositions of the invention provide greater than a 99% reduction (2-log order reduction), more preferably greater than a 99.99% reduction (4-log order reduction), and most preferably greater than a 99.999% reduction (5-log order reduction) in such population within 10 minutes at 60°C.
• These surfaces can be those typified as "hard surfaces” (such as walls, floors, bed-pans, etc.,), or woven and non- woven surfaces (such as surgical garments, draperies, bed linens, bandages, etc.,), or patient-care equipment (such as respirators, diagnostic equipment, shunts, body scopes, wheel chairs, beds, etc.), or surgical and diagnostic equipment.
• Health care surfaces include articles and surfaces employed in animal health care.
• microorganisms refers to any noncellular or unicellular (including colonial) organism. Microorganisms include all prokaryotes. Microorganisms include bacteria (including cyanobacteria and
• compositions of the present invention can include an antimicrobial agent such as a lipid, a fatty acid and/or a low HLB antimicrobial agent.
• suitable antimicrobial agents include fatty acid or carboxylic acid antimicrobial agents.
• preferred fatty acid antimicrobial agents include medium chain fatty acids, including C6-C16 a i k yi carboxylic acids, such as hexanoic acid, butyric acid, octanoic acid, heptanoic acid, nonionic acid, and decanoic acid.
• the fatty acid antimicrobial agent an C8-C 12 alkyl carboxylic acid, still more preferably C9-C 10 alkyl carboxylic acid, such as decanoic acid (capric acid). It is to be understood that mixtures of antimicrobial agents can be used if desired.
• suitable fatty acid antimicrobial agents include an aliphatic or aromatic fatty acid, either saturated or unsaturated, having from about 6 to about 16 carbon atoms, or mixtures of these fatty acids.
• the aliphatic fatty acid is saturated.
• the fatty acid includes about 8 to about 12 carbon atoms. In an embodiment the fatty acid includes about 9 to about 10 carbon atoms.
• the fatty acid can be linear, branched or cyclic and can contain substituent atoms such as hydroxyl groups or ether linkages as long as the substituents do not affect antimicrobial activity. Suitable fatty acids include, for example, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, myristic acid, or mixtures thereof.
• the fatty acid includes heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, or mixtures thereof. In an embodiment, the fatty acid preferably includes decanoic acid.
• compositions of the invention contain sufficient antimicrobial agent to achieve the desired rate and efficacy for microbial reduction from a solid concentrated composition.
• the antimicrobial agent can be present in a solid concentrated composition 0.1 to about 35 wt-%, about 0.1 to about 30 wt-%, about 0.1 to about 25 wt-%, about 0.1 to about 20 wt-%, about 0.1 to about 15 wt-%, about 0.1 to about 10 wt-%, about 0.5 to about 10 wt-%, about 0.5 to about 7 wt-%, or about 0.5 to about 5 wt-%.
• the antimicrobial agent can be present at any of these amounts not as part of a range and/or at any of these amounts not modified by about.
• the antimicrobial compositions of the invention may optionally be formulated to contain an additional antimicrobial agent.
• This additional antimicrobial agent can be dissolved or dispersed in the antimicrobially- active solvent or in a diluting solvent.
• Suitable additional antimicrobial agents include carboxylic acids, diacids, or triacids (e.g.
• dodecylbenzene sulfonic acid iodo-compounds or active halogen compounds (e.g., iodine, interhalides, polyhalides, metal hypochlorites, hypochlorous acid, metal hypbromites, hypobromous acid, chloro- and bromo-hydantoins, chlorine dioxide and sodium chlorite), active oxygen compounds including hydrogen peroxide, isolated or equilibrium derived or isolated per acids such as chloroperbenzoic acids, peracetic acid, perheptanoic acid, peroctanoic acid, perdecanoic acid, performic acid, percitric acid, perglycolic acid, perlactic acid, perbenzoic acid, and monoester peracids derived from diacids or diesters (e.g., such as adipic, succinic, glutaric, or malonic acid and mixtures thereof), organic peroxides including benzoyl peroxide, alkyl benzoyl peroxides
• compositions can include any of a variety of ethoxylated amines.
• the ethoxylated amine may be branched or unbranched according to one of the following formulas: or
• R can be a straight or branched alkyl or alkylaryl substituent.
• R can be a substituent having from 1 to 24 carbon atoms and each n can be from 1 to 20.
• n is from 1 to 16, from 1 to 15, from 1 to 14, from 1 to 13, from 1 to 12, from 1 to 11, from 1 to 10, from 1 to 9, from 1 to 8, from 1 to 6, from 1 to 5, from 1 to 4, or from 1 to 3.
• R is derived from coconut oil and n is between 1 to
• the R groups of the ethoxylated amine provide sufficient solubility to stabilize and solubilize the fatty acid antimicrobial agent within an aqueous solution.
• the surfactant does not include an alcohol and is a medium to short chain carbon group having less than 24 carbon atoms.
• the ethoxylated amine is a cocoamine. Ethoxylated cocoamines are commercially available, for example, under tradenames such as Varonic (Evonik Industries) and Toximul (Stepan Company), including Varonic K- 210 and Toximul CA 7.5.
• the ethoxylated cocoamine provides physical stability to a concentrate or use antimicrobial composition, while retaining the solubility and clarity of the concentrate or use solution, and/or without inhibiting action of the fatty acid antimicrobial agent.
• the composition includes an ethoxylated cocoamine as the primary solubilizing (coupling) or emulsifying agent.
• compositions of the invention contain sufficient ethoxylated amine surfactant to achieve the desired solubility of the use solution without interfering with the efficacy of microbial reduction.
• the ethoxylated amine can be present in a use composition, such as a use solution at about 0.005 to about 25 wt-%, about 0.01 to about 20 wt-%, about 0.01 to about 5 wt-%, about 0.015 to about 3 wt-%, about
• antimicrobial agent such as decanoic acid.
• the composition comprises
• the ethoxylated amine and fatty acid antimicrobial agent have a weight ratio of about 5.5: 1 to about 3: 1, and wherein the composition is clear and has effective antimicrobial activity.
• the fatty acid antimicrobial agent comprises octanoic acid, heptanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, myristic acid, isomers thereof, or mixtures thereof and the ethoxylated amine has a hydrophile-lipohile balance (HLB) from about 7.5 to about 14.
• HLB hydrophile-lipohile balance
• the HLB of the ethoxylated amine is from about 10 to about 14 and the R group of the ethoxylated amine is a substituent comprising a mixture of saturated and unsaturated fatty acids with 6-18 carbons. More preferably the R group is a substituent derived from coconut oil. Still further, according to an embodiment the ration of ethoxylated amine and fatty acid antimicrobial agent is about 5.5: 1 to about 3: 1.
• the present compositions can include one or more ingredient to decrease the pH, e.g. one or more acids or acidulants.
• Suitable acids include organic and inorganic acids.
• suitable inorganic acids include phosphoric acid, hydrochloric acid, nitric acid, sulfuric acid, sulfamic acid, mixtures thereof, or the like.
• suitable organic acids include lactic acid, citric acid, propionic acid, acetic acid, hydroxyacetic acid, formic acid, glutaric acid, malic acid, hydroxy propionic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, mixtures thereof, or the like.
• the acid includes phosphoric acid, lactic acid, or a mixture thereof.
• the acid includes phosphoric acid, lactic acid, hydroxyacetic acid, or a mixture thereof.
• the acid includes citric acid, lactic acid, urea hydrochloride, or a mixture thereof.
• a variety of fluids can be used as the diluting solvent, including water in its liquid form.
• the compositions of the invention can be formulated to include the diluting solvent ⁇ e.g., water) as sold, or the diluting solvent can be added at any time up to the time of use.
• the concentrates of the invention contain little or no diluting solvent as sold.
• a variety of dilution ratios can be employed, so long as the diluted composition exhibits the desired antimicrobial behavior when applied to the target microbes.
• the ingredients in the concentrate can represent about 1 to about 99 wt-% of the diluted mixture.
• the diluted composition preferably contains antimicrobially-active solvent in an amount near the solubility limit of the antimicrobially-active solvent in the diluting solvent.
• the diluted antimicrobial compositions preferably are aqueous, contain additional antimicrobial agent, and are clear or quasi-stable. For example, water can be used to dilute an antimicrobial composition to a preferred use concentration of
• the present compositions can include one or more solvents including organic and aqueous solvents.
• suitable organic solvents include isopropanol, other lower alcohols, glycol ethers, mixtures thereof, or the like.
• suitable aqueous solvents include water, mixtures of water with the organic solvent, mixtures thereof, or the like.
• the solvent includes isopropanol, water, or a mixture thereof.
• the present compositions can include one or more surfactants.
• the surfactant or surfactant admixture can include nonionic, semi-polar nonionic, or anionic surface-active agents; or any combination thereof.
• concentration of surfactant or surfactant mixture useful in use solution compositions fall in the range of from about 0.01 to about 30 wt-%, about 1 to about 30 wt-%, about 2 to about 20 wt-%, or about 5 to about 15 wt-%.
• These percentages can refer to percentages of the commercially available surfactant composition, which can contain solvents, dyes, odorants, and the like in addition to the actual surfactant. In this case, the percentage of the actual surfactant chemical can be less than the percentages listed. These percentages can refer to the percentage of the actual surfactant chemical.
• Surfactant can be present at any of these amounts not as part of a range and/or at any of these amounts not modified by about.
• the surfactant includes anionic surfactant, amphoteric surfactant, nonionic surfactant, or mixture thereof.
• the surfactant includes a nonionic surfactant.
• Nonionic surfactants useful in the invention are generally characterized by the presence of an organic hydrophobic group and an organic hydrophilic group and are typically produced by the condensation of an organic aliphatic, alkyl aromatic, fatty alcohol, or
• polyoxyalkylene hydrophobic compound with a hydrophilic alkaline oxide moiety which in common practice is ethylene oxide or a polyhydration product thereof, polyethylene glycol.
• any hydrophobic compound having a hydroxyl, carboxyl, amino, or amido group with a reactive hydrogen atom can be condensed with ethylene oxide, or its polyhydration adducts, or its mixtures with alkoxylenes such as propylene oxide to form a nonionic surface-active agent.
• the length of the hydrophilic polyoxyalkylene moiety which is condensed with any particular hydrophobic compound can be readily adjusted to yield a water dispersible or water soluble compound having the desired degree of balance between hydrophilic and hydrophobic properties.
• the present compositions can include one or more sequestrants.
• Suitable sequestrants include organic chelating compounds that sequester metal ions in solution, particularly transition metal ions.
• Such sequestrants include organic amino- or hydroxy-polyphosphonic acid complexing agents (either in acid or soluble salt forms), carboxylic acids, hydroxycarboxylic acids, or aminocarboxylic acids.
• the present composition can also include any number of adjuvants, including for example, stabilizing agent, wetting agent, thickener, foaming agent, pigment or dye among any number of constituents which can be added to the composition.
• adjuvants can be preformulated with the present composition or added to the system simultaneously, or even after, the addition of the present composition.
• the composition can also contain any number of other constituents as necessitated by the application, which are known and which can facilitate the activity of the present compositions. The types and amounts of such adjuvants and/or constituents will be apparent to those skilled in the art.
• compositions according to the invention that retain a clear one-phase mixtures.
• embodiments of the invention may include a slightly cloudy phase dispersion where the solubility limits of the antimicrobial agents are approached. It is to be understood that compositions having saturated antimicrobial agent solubility could be employed if desired. However, preferred embodiments of the invention achieve antimicrobial agent solubility without having to increase the ratio of surfactant to antimicrobial agent.
• the level of active components in the concentrate composition is dependent on the intended dilution factor and the desired activity of the fatty acid
• a dilution of about 0.1 to about 25 ounces of concentrate composition per gallon of diluent provides a suitable use composition.
• diluent e.g., water
• Higher use dilutions can be employed if elevated use temperature (greater than
• antimicrobial composition can be sprayed or wiped onto a surface; the composition can be caused to flow over the surface, or the surface can be dipped into the composition.
• the compositions can be formulated as liquids, gels, aerosols, waxes, solids, or powders. If steam or another gaseous diluting solvent is employed, then the compositions can be formulated to be applied in a gaseous state.
• the antimicrobial compositions according to the invention can be used for a variety of domestic or industrial applications, e.g., to reduce microbial populations on a surface or object.
• the compositions can be applied in a variety of areas including kitchens, bathrooms, factories, hospitals, dental offices and food plants, and can be applied to a variety of hard or soft surfaces having smooth, irregular or porous topography.
• Suitable hard surfaces include, for example, architectural surfaces (e.g., floors, walls, windows, sinks, tables, counters and signs); eating utensils; hard-surface medical or surgical instruments and devices; and hard-surface packaging.
• Such hard surfaces can be made from a variety of materials comprising, for example, ceramic, metal, glass, wood or hard plastic.

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• Life Sciences & Earth Sciences (AREA)
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• Agricultural Chemicals And Associated Chemicals (AREA)
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