JP5198769B2 - カルボン酸及びアルコキシル化アミンを含む抗微生物組成物 - Google Patents
カルボン酸及びアルコキシル化アミンを含む抗微生物組成物 Download PDFInfo
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- JP5198769B2 JP5198769B2 JP2006522558A JP2006522558A JP5198769B2 JP 5198769 B2 JP5198769 B2 JP 5198769B2 JP 2006522558 A JP2006522558 A JP 2006522558A JP 2006522558 A JP2006522558 A JP 2006522558A JP 5198769 B2 JP5198769 B2 JP 5198769B2
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- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
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- 230000003165 hydrotropic effect Effects 0.000 description 1
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- 239000011777 magnesium Substances 0.000 description 1
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- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
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- FLZHCODKZSZHHW-UHFFFAOYSA-N n,n-dipropyltetradecan-1-amine oxide Chemical compound CCCCCCCCCCCCCC[N+]([O-])(CCC)CCC FLZHCODKZSZHHW-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
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- 235000016046 other dairy product Nutrition 0.000 description 1
- AUONHKJOIZSQGR-UHFFFAOYSA-N oxophosphane Chemical compound P=O AUONHKJOIZSQGR-UHFFFAOYSA-N 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920001748 polybutylene Polymers 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 235000019338 polyoxypropylene-polyoxyethylene polymer Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 150000003109 potassium Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- IKNCGYCHMGNBCP-UHFFFAOYSA-N propan-1-olate Chemical compound CCC[O-] IKNCGYCHMGNBCP-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
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- 229910000077 silane Inorganic materials 0.000 description 1
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- 229940048842 sodium xylenesulfonate Drugs 0.000 description 1
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
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- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 150000004026 tertiary sulfonium compounds Chemical class 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229910001428 transition metal ion Inorganic materials 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicinal Preparation (AREA)
Description
本明細書において使用される「微生物」の語は、いずれかの非細胞又は単細胞(コロニーを含む)生物を意味する。微生物はすべての原核生物を含む。微生物は細菌(シアノバクテリア及び放線菌を含む)、地衣類、微真菌、原虫、ビリノ、ウイロイド、ウイルス、真菌(例えば、カビ及び酵母)、及びいくつかの藻類を含む。本明細書において使用される「微生物」(microbe)の語は微生物(microoganism)と同義である。
本発明は、カルボン酸、例えば、抗微生物剤、及びアルコキシル化アミンを含む抗微生物組成物に関する。ある態様において当該組成物は、安定で且つ透明な濃縮組成物を形成し、且つ抗微生物活性を維持する。当該組成物のある態様は、1又は複数の利益を供することができる。ある態様において、当該組成物は、水性溶媒中にカルボン酸を結合するためにアルコキシル化アミンを利用する。ある態様において、当該アミンはカルボン酸と複合体化又は反応することなく、酸性組成物中にカルボン酸を結合することができる。ある態様において、当該組成物は透明で安定な使用溶液を形成できる。ある態様において、当該組成物はカルボン酸の抗微生物活性を維持することができる。有利には、当該組成物の態様は有効な汚れ除去を供する。
本発明組成物は、いずれかの多様なアルコキシル化アミンを含んでよい。ある態様において、アルコキシル化アミンは一般式I:N(R1)(R2)(R3)(R4)を有し、式中R1、R2、又はR3の少なくとも1つはアルコキシレート又はエーテル部分を含む。R4は、水素、直鎖若しくは分枝鎖アルキル、又は直鎖又は分枝鎖アルキルアリールであってよい。当該アルコキシル化アミンは、一級、二級又は三級アミンであってよい。ある態様において、アルコキシル化アミンは三級アミンである。ある態様において、各R2及びR3は、アルコキシレート部分、例えば、1又は複数のエトキシレート部分、1又は複数のプロポキシレート部分、又はこれらの組み合わせを含み、そしてR4は水素である。例えば、R1、R2、又はR3の1つは、エーテル部分を含み、そして他の2つは1又は複数のエトキシレート、1又は複数のプロポキシレート、又はこれらの組み合わせを含んでよい。ある態様において、各、R1、R2、又はR3は、アルコキシレート部分、例えば、1又は複数のエトキシレート部分、1又は複数のプロポキシレート部分、又はこれらの組み合わせを含み、そしてR4は水素である。
式VIII中、R4は直鎖又は分枝鎖のC1〜C13アリールアルキル又はアルキルであってよく、そしてR5は直鎖又は分枝鎖のC1〜C6アルキルであってよい。
本組成物は、抗微生物剤、例えば、脂質製、脂肪性又は油性、及び/又は低HLB型抗微生物剤を含んでよい。適当な抗微生物剤は、カルボン酸抗微生物剤を含む。カルボン酸抗微生物剤は、いわゆる脂肪酸抗微生物剤を含む。
本組成物は、pHを下げるために1又は複数の成分、例えば、1又は複数の酸又は酸味料を含んでよい。例えば、適当な無機酸は、リン酸、塩酸、硝酸、硫酸、スルファミン酸、又はこれらの混合物等を含む。例えば、適当な有機酸は、乳酸、クエン酸、プロピオン酸、酢酸、ヒドロキシ酢酸、ギ酸、グルタル酸、リンゴ酸、ヒドロキシプロピオン酸、コハク酸、グルタル酸、アジピン酸、フマル酸、又はこれらの混合物等を含む。当該有機酸は、商品名 Sokalan として販売されているアジピン酸、リンゴ酸、及びコハク酸の混合物でよい。ある態様において、当該酸はリン酸、乳酸、ヒドロキシ酢酸、又はこれらの混合物でよい。ある態様において、当該酸はクエン酸、乳酸、ウレア塩酸、又はこれらの混合物でよい。
本組成物は、1又は複数の界面活性剤を含んでよい。当該界面活性剤又は界面活性剤混合物は、非イオン性界面活性剤、半極性界面活性剤、非イオン性罫面、又は陰イオン性界面活性剤;又はこれらのいずれかの組み合わせを含んでよい。一般的に、本発明の組成物において有用な界面活性剤又は界面活性剤混合物の濃度は、約0.01〜約30wt−%、約0.01〜約5wt−%、約0.03〜約0.3wt−%、約0.05〜約20wt−%、約0.1〜約20wt−%、約0.1〜約10wt−%、約0.1〜約5wt−%、約0.3〜約3wt−%、約0.5〜約15wt−%、約1〜約30wt−%、約1〜約20wt−%、約1〜約10wt−%、約1〜約5wt−%、約2〜約20wt−%、約2〜約10wt−%、約3〜約7wt−%、又は約5〜約15wt−%の範囲にある。界面活性剤は、約1〜約20wt−%、約2〜約10wt−%、又は約3〜約7wt−%において存在してよい。当該界面活性剤は、約1〜約30wt−%、約2〜約20wt−%、又は約5〜約15wt−%において存在してよい。これらのパーセンテージは、商業的に入手可能な界面活性組成物のパーセンテージを意味し、実際の界面活性剤に追加して溶媒、色素、匂い物質等を含んでよい。この場合、実際の界面活性剤活性化学物質のパーセンテージは上に挙げたパーセンテージよりも低くてよい。界面活性剤は、範囲の一部としてでないこれらのいずれかの量及び/又は約の語により修飾されていないこれらのいずれかの量において存在してよい。
本発明に有用な非イオン性界面活性剤は、一般的に有機疎水性基、及び有機親水性基の存在により特徴づけられ、そして典型的には、有機脂肪族、アルキル芳香族、脂肪酸アルコール、又はポリオキシアルキレン疎水性化合物と、慣習的にはエチレンオキシド又はそのポリ水和生成物のポリエチレングリコールである親水性アルカリオキシド部分との縮合により産出される。特に、反応性の水素原子を有するヒドロキシル、カルボキシル、アミノ、又はアミド基を有するいずれかの疎水性化合物は、エチレンオキシド、又はそのポリ水和付加物、又はアルコキシレン、例えば、プロピレンオキシドを伴う混合物と縮合し、非イオン性界面活性剤を形成することができる。いずれかの特定の疎水性化合物と縮合される当該親水性ポリオキシアルキレン部分の長さは、所望する程度の親水性と疎水性特性のバランスを有する水分散性又は水溶性化合物を産出するために、容易に調節することができる。
1.開始反応性水素化合物として、プロピレングリコール、エチレングリコール、グリセロール、トリメチロプロパン、及びエチレンジアミンに基づくポリオキシプロピレン−ポリオキシエチレン重合体化合物ブロック。開始剤としての連続プロポキシル化及びエトキシル化重合体化合物の例は、BASF Corpにより製造される商品名プルロニック(Pluronic)(登録商標)及び テトロニック(Tetronic)(登録商標)において商業的に入手可能である。
5.指定された分子量の親水性部分を供するためにエチレンオキシドをエチレングリコールに付加することにより;及び、それから分子の外側(端)において、疎水性ブロックを得るためにプロピレンオキシドを付加することにより、本質的に逆になった修飾された(1)由来の化合物。当該疎水性タンパク質の分子量は約1,000〜約3,100であり、中心の親水性部分は最終分子の10重量%〜約80重量%を含む。これらの逆プルロニック(Pluronic)(登録商標)は、BASF Corporation により商品名Pluronic(登録商標) R 又は L 界面活性剤として製造されている。
7.1959年9月8日にBrownらによって発行された米国特許第2,903,486号の以下の式により表されるアルキルフェノキシポリエトキシアルカノール:
半極性型の非イオン性界面活性剤は、本発明の組成物において有用な非イオン性界面活性剤である。一般的に、半極性非イオン性は、高フォーマー及び泡安定化剤であり、CIPシステムにおけるこれらの適用を制限しうる。しかしながら、高泡洗浄法のために設計された当該発明の組成態様において、半極性非イオン性は即時の有用性を有する。当該半極性非イオン性界面活性剤は、アミンオキシド、ホスフィンオキシド、スルホキシド、及びこれらのアルコキシル化誘導体を含む。
また、本発明において有用なものは、疎水性部分における電荷が陰性であるために陰イオン性として分類される界面活性物質;又はpHが中性又はそれ以上に上昇しない限り分子の疎水性部位が電荷を保有しない界面活性剤(例えば、カルボン酸)である。カルボン酸塩、スルホン酸塩、スルフェート、及びリン酸塩は、陰イオン性界面活性剤中でみられる極性(親水性)安定化群である。これらの極性群に関するカチオン(カウンターイオン)のナトリウム、リチウム、及びカリウムは、水溶性を与え;アンモニウム及び置換アンモニウムイオンは水溶性及び油溶性を供し;そしてカルシウム、バリウム、及びマグネシウムは油溶性を促進する。
双性イオン界面活性剤は、両性界面活性剤のサブセットであると考えられる。双性イオン界面活性剤は二級及び三級アミンの誘導体、複素環式二級及び三級アミンの誘導体、又は四級アンモニウムの誘導体、四級ホスホニウム又は三級スルホニウム化合物として広く記載されている。典型的には双性イオン界面活性剤は、正電荷四級アンモニウム、又はあるケースにおいては、スルホニウム又はホスホニウムイオン;負電荷カルボキシル基;及びアルキル基を含む。双性イオン界面活性剤は、一般的に、分子の等電点領域において同程度にイオン化し、そして正−負電荷中心間に強力な「内部塩」誘引を発生することができる陽イオン性及び陰イオン性基を含む。このような双性イオン合成界面活性剤の例は、脂肪族四級アンモニウム、ホスホニウム、及びスルホニウム化合物の誘導体を含み、脂肪族ラジカルは直鎖又は分枝鎖であってよく、そしてここで脂肪族置換基の1つは8〜18の炭素原子を含み、そして1つは陰イオン性水溶性基、例えば、カルボキシ、スルホネート、スルフェート、ホスフェート、又はホスホネートを含む。ベタイン及びスルタイン界面活性剤は、本明細書における使用のための代表的な双性イオン界面活性剤である。
本組成物は1又は複数の溶媒を含んでよい。適当な溶媒は有機及び水性溶媒を含む。例えば、適当な有機溶媒は、イソプロパノール、他の低級アルコール、グリコールエーテル、これらの混合物等を含む。例えば、適当な水性溶媒は、水、水と有機溶媒の混合物、これらの混合物等を含む。ある態様において、当該溶媒は、イソプロパノール、水、又はこれらの混合物を含む。
本組成物は1又は複数の捕捉剤を含んでよい。適当な捕捉剤は、溶液中の金属イオン、特に遷移金属イオンを捕捉する有機キレート化化合物を含む。これらの捕捉剤は、有機アミノ−、又はヒドロキシ−ポリホスホン酸錯化剤(酸又は可溶酸形態のいずれか)、カルボン酸、ヒドロキシカルボン酸、又はアミノカルボン酸を含む。
本組成物はまた、いずれかの数のアジュバントを含んでよい。特に、当該組成物は、組成物に添加することができるいずれかの数の成分において安定化剤、湿潤剤、増粘剤、発泡剤、ピグメント、又は色素を含んでよい。このようなアジュバントは本組成物で前もって処方することができ、又は本組成物の添加と同時に、又は後に当該系に添加することができる。当該組成物はまた、適用により必要とされる、既知で且つ本組成物の活性を促進できる、いずれかの数の他の成分を含んでよい。
上記組成物はまた、消泡を補助するために必要な追加的な成分を含んでよい。一般的に、本発明に関して使用できる消泡剤は、シリカ及びシリコン;脂肪酸又はエステル;アルコール;スルフェート又はスルホネート;アミン又はアミド;ハロゲン化化合物、例えば、フルオロクロロ炭化水素;植物油、ワックス、ミネラル油、並びにこれらの硫酸化誘導体;並びにホスフェート及びリン酸エステル、例えば、アルキル及びアルカリ性ジホスフェート、及びトリブチルホスフェート等;及びこれらの混合物を含む。
本発明において有用な増粘剤は、酸性系に適合性のものを含む。適当な増粘剤は、
食品又は食品プロセス機器の表面における汚れを残さない。即ち、好ましくは増粘剤又はゲル化剤は、接触部分において、食品又は他のセンシティブな製品に不適合な成分を含まない。
多様な色素、香料を含む匂い物質、及び他の美的増強剤もまた、本組成物中に含んでよい。色素は、組成物の外観を変化させるために、FD&C色素、D&C色素等のいずれかの種類として含んでよい。更に適当な色素は Direct Blue 86 (Miles), Fastusol Blue (Mobay Chemical Corp.), Acid Orange 7 (American Cyanamid), Basic Violet 10 (Sandoz), Acid Yellow 23 (GAF), Acid Yellow 17 (Sigma Chemical), Sap Green (Keyston Analine and Chemical), Metanil Yellow (Keystone Analine and Chemical), Acid Blue 9 (Hilton Davis), Sandolan Blue/Acid Blue 182 (Sandoz), Hisol Fast Red (Capitol Color and Chemical), Fluorescein (Capitol Color and Chemical), Acid Green 25 (Ciba-Geigy), Pylakor Acid Bright Red (Pylam)等を含んでよい。
本発明の組成物は、抗微生物活性物質、アルコキシル化アミン、及びいずれかの他の成分を組み合わせることにより処方できる。例えば、これらの成分は、濃縮物又は超濃縮組成物を形成するために混合することができ、使用組成物を形成するために、使用場所で希釈することができる。
本発明の組成物は、例えば、表面、又は対象における、又は水体、又は水流中の微生物又はウイルスの個体数を減少させるために、多様な家庭的又は工業的な適用に使用できる。当該組成物は、キッチン、バスルーム、工場、病院、歯科、及び食品プラントを含む多様な場所において適用することができ、そして多様な、滑らかな、不規則な又は多孔性の組織分布を有するハード又はソフト表面に適用することができる。
適当なハード表面は、例えば、建築的表面(例えば、床、壁、窓、シンク、テーブル、カウンター、及び標識);食事用品;ハード表面の医用又は外科用機器及び装置;及びハード表面の包装を含む。このようなハード表面は多様な物質、例えば、セラミック、金属、ガラス、木材、又はハードプラスチックから作製できる。適当なソフト表面は、例えば、紙;フィルターメディア、病院用及び外科用リネン、及び衣服;ソフト表面の医用又は外科用機器及び装置;及びソフト表面の包装を含む。このようなソフト表面は、多様な材料、例えば、紙、繊維、布、又は非布生地、ソフトプラスチック及びエラストマーから作製できる。本発明の組成物はまた、ソフト表面、例えば、食品及び皮膚に適用することもできる。
物質
本実施例で使用される物質は以下を含む:アルコキシル化アミン1、式:R−(PO)2N[EO]2.5−H[EO]2.5−Hにより記載できるC12〜C14プロポキシアミンエトキシレート。アルコキシル化アミン2、式:R−(PO)10N[EO]2.5−H[EO]2.5−Hにより記載できるC12〜C14プロポキシアミンエトキシレート。アルコキシル化アミン3、の式:R−(PO)5N[EO]2.5−H[EO]2.5−Hにより記載できるC12〜C14プロポキシアミンエトキシレート。アルコキシル化アミン4、ポリ(5)オキシエチレンイソデシルオキシプロピルアミンとして知られ、エーテル酸素がない分枝鎖C10H21アルキル基を有する三級エトキシル化アミン。アルコキシル化アミン5、式R−O−CH2CH2CH2N(H)(CH2CH2CH2NH2)(式中Rは分枝鎖C10アルキルである)により記載できるジアミン。アルコキシル化アミン6、イソ−(2−ヒドロキシエチル)イソデシルオキシプロピルアミンとして知られ、エーテル酸素がない分枝鎖C10H21アルキル基を有する三級エトキシル化アミン。
表1〜5は、実施例1において利用されるいくつかの試験組成物において利用される成分及び量を挙げる。当該多様な組成物は、例えば、オーダーリスト中の成分を混合することにより作製した。他に示さない限り、混合は、透明な同様の溶液を産出した。使用のために、濃縮組成物は、手動又は既知の分配機器で希釈した。表に挙げた成分の量は、wt−%で与える。
試験組成物は、アルコキシル化アミン変化量及びタイプで作製した。これらは、2.4wt−%のオクタン酸、21wt−%のリン酸(75%)、8.0wt−%の酢酸、変化量のアルコキシル化アミンを含むように残りの水で作製した。これらの組成物は、表6中に示される可溶化有効特性を示す。
物質
実施例2に使用される物質は、実施例1の組成物のために使用される多くのものを含む。実施例2に使用される物質は、以下を含む:他のアミンとの混合物中に存在することができる、アルコキシル化アミン7、CAS番号68213−26−3による化学名N,N−ビス−2(オメガ−ヒドロキシポリオキシエチレン/ポリオキシプロピレン)エチルアルキルアミン、又はN,N−ビス(ポリオキシエチレン/プロピレン)牛脂アルキルアミンにより、及び/又は化学式C64H130O18により記載されるアルキルアミンエトキシレートプロポキシレート;アルコキシル化アミン8、Tomah E−17−2、ビス(2−ヒドロキシエチル)イソトリデシルオキシプロピルアミン;アルコキシル化アミン9、Tomah E−19−7、直鎖状C12及びC15アルキル鎖を伴うポリ(7)オキシエチレン直鎖状アルキルオキシプロピルアミン;SXS(40%)、キシレンスルホン酸ナトリウム(40%溶液);Tomah AO−455、低起泡性アミンオキシド;Tomah Q−17−2pg、プロピレングリコール中の74%活性イソトリデシルオキシビス(2−ヒドロキシエチルメチルアンモニウムクロリド);Tomah Q−17−2ipa、イソプロパノール中の74%活性イソトリデシルオキシプロピルビス(2−ヒドロキシエチルメチルアンモニウムクロリド);Tomah Q−14−2、プロピレングリコール中の74%活性イソトリデシルビス(2−ヒドロキシエチルメチルアンモニウムクロリド)。
表7〜9は、実施例2において利用されるいくつかの試験組成物において利用される成分及び量を挙げる。当該多様な組成物は、例えば、オーダーリスト中の成分を混合することにより作製した。他に示さない限り、混合は、透明な同様の溶液を産出した。使用のために、濃縮組成物は、手動又は既知の分配機器で希釈した。表に挙げた成分の量は、wt−%で与える。
組成物1〜8は、40〜122°Fで、少なくとも7日間透明性を維持した。これらの条件下において、組成物11及び12は、主に僅かに濁った。これらの実験の結果は表10及び11に示す。122°Fにおいて古くさせた組成物は2wt−%の使用溶液に希釈し、これらの外観を記録した。当該使用溶液は、主に濁り又は僅かに濁った。組成物19は、驚くべき有効な抗微生物化性を示した。
Claims (8)
- 0.005〜20重量%の脂肪酸抗微生物剤、0.2〜70重量%のアルコキシル化アミン、及び1又は複数の酸を含む組成物であって、該アルコキシル化アミンが:
式:R−(PO)10N[EO]2.5−H[EO]2.5−HのC12〜C14プロポキシアミンエトキシレート;
式:R−(PO)5N[EO]2.5−H[EO]2.5−HのC12〜C14プロポキシアミンエトキシレート;
式:R−(PO)2N[EO]2.5−H[EO]2.5−HのC12〜C14プロポキシアミンエトキシレート;
エーテル酸素のない分枝C10H21アルキル基を有する、ポリ(5)オキシエチレンイソデシルオキシプロピルアミン;
エーテル酸素のない分枝C10H21アルキル基を有する、イソ−(2−ヒドロキシエチル)イソデシルオキシプロピルアミン;又は、
これらの混合物であり、
該アルコキシル化アミンと脂肪酸抗微生物剤が、1:1〜9:1の重量比において存在し、
ここで該組成物が透明でありかつ有効な抗微生物活性を有することを特徴とする、組成物。 - 前記カルボン酸抗微生物剤が、C6−C14アルキルカルボン酸、又はこれの塩若しくはエステルである、請求項1に記載の組成物。
- 前記C6−C14アルキルカルボン酸が、オクタン酸、ヘプタン酸、デカン酸、ドデカン酸、ミリスチン酸、又はこれらの混合物から成る群から選択される、請求項2に記載の組成物。
- 前記C8−C14アルキルカルボン酸が、オクタン酸である、請求項2に記載の組成物。
- 対象における微生物個体群を減少させる方法であって、該対象を0.005〜20重量%の脂肪酸抗微生物剤、0.2〜70重量%の式III
該アルコキシル化アミンと脂肪酸抗微生物剤が、1:1〜9:1の重量比において存在し、
ここで該組成物が透明でありかつ有効な抗微生物活性を有することを特徴とする、方法。 - 前記アルコキシル化アミンとカルボン酸抗微生物剤の比が3:1である、請求項6に記載の組成物。
- 前記カルボン酸がオクタン酸である、請求項6に記載の組成物。
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US10/634,196 US7341983B2 (en) | 2003-08-04 | 2003-08-04 | Antimicrobial compositions including carboxylic acids and alkoxylated amines |
US10/634,196 | 2003-08-04 | ||
PCT/US2004/020776 WO2005015996A1 (en) | 2003-08-04 | 2004-06-28 | Antimicrobial compositions including carboxylic acids and alkoxylated amines |
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JP2007501228A JP2007501228A (ja) | 2007-01-25 |
JP5198769B2 true JP5198769B2 (ja) | 2013-05-15 |
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JP (1) | JP5198769B2 (ja) |
AU (1) | AU2004264850B2 (ja) |
BR (1) | BRPI0413259B1 (ja) |
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WO (1) | WO2005015996A1 (ja) |
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US7341983B2 (en) | 2008-03-11 |
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AU2004264850A1 (en) | 2005-02-24 |
BRPI0413259A (pt) | 2006-10-03 |
CA2532276A1 (en) | 2005-02-24 |
JP2007501228A (ja) | 2007-01-25 |
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