WO2012137953A1 - Composition de nutriments pour animaux - Google Patents

Composition de nutriments pour animaux Download PDF

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Publication number
WO2012137953A1
WO2012137953A1 PCT/JP2012/059594 JP2012059594W WO2012137953A1 WO 2012137953 A1 WO2012137953 A1 WO 2012137953A1 JP 2012059594 W JP2012059594 W JP 2012059594W WO 2012137953 A1 WO2012137953 A1 WO 2012137953A1
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WIPO (PCT)
Prior art keywords
composition according
composition
animal
coenzyme
coq10
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PCT/JP2012/059594
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English (en)
Japanese (ja)
Inventor
貴史 吉村
池本　一人
賢司 湯浅
雅子 山下
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三菱瓦斯化学株式会社
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Publication of WO2012137953A1 publication Critical patent/WO2012137953A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/20—Feeding-stuffs specially adapted for particular animals for horses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Definitions

  • the present invention relates to a composition for use in enhancing endurance and / or improving fatigue comprising coenzyme Q10.
  • the present invention also relates to a nutritional composition for animals containing coenzyme Q10, a seaweed extract and a branched chain amino acid.
  • the present invention relates to use in racing animals.
  • Coenzyme Q10 (hereinafter sometimes referred to as “CoQ10”) is a physiological component that is widely distributed in the living world and exists as a component of the mitochondrial electron transport system in cells in the living body.
  • CoQ10 is a benzoquinone derivative, and plays a role as a transmission component in the electron transfer system by repeating oxidation and reduction in a living body. Its usefulness is widely known since it exhibits energy production and antioxidant activity in vivo. For example, it is used for pharmaceutical use as a congestive heart failure drug.
  • CoQ10 is fat-soluble, difficult to mix with water, and difficult to make a uniform solution.
  • low dispersibility in water leads to low absorbency, and it is difficult to exert an effect.
  • due to the poor dispersibility in water if it is packed in a container such as a syringe, it will cause separation and clogging.
  • Fluorotannin derived from seaweed is known to have an antioxidant effect, a vasodilatory effect, an anti-inflammatory effect and a preventive effect on heart diseases.
  • Phlorotannins which have a vasodilating effect, function significantly in promoting blood circulation, especially during intense exercise (Patent Documents 1 to 3).
  • amino acids having a branched structure include valine, leucine, and isoleucine. These branched chain amino acids are the only essential amino acids that provide muscle energy. It is an energy source that can be used efficiently when exercising. In addition, this branched chain amino acid has a function of suppressing proteolysis in muscle during intense exercise and is a very useful component for exercise.
  • Patent Document 4 nutritional supplements containing CoQ10, cyanocobalamin, folic acid, and pyridoxine hydrochloride have been known so far.
  • CoQ10's fatigue improving action and endurance enhancing effect are known. Not listed.
  • none of the nutritional components aims to increase anti-fatigue and / or endurance, and supports the effects.
  • the present inventors have found that coenzyme Q10 is effective in enhancing the endurance of animals and / or improving fatigue.
  • the present invention is based on this finding.
  • An object of the present invention is to provide a nutritional composition for animals having endurance enhancing action and anti-fatigue action, that is, a composition for use in animal endurance enhancement and / or fatigue improvement.
  • a composition for use in enhancing endurance and / or improving fatigue comprising coenzyme Q10.
  • coenzyme Q10 is used as a mixture with a soy protein or a hydrolyzate thereof, or an emulsified composition.
  • the composition according to (1) or (2) further comprising a seaweed extract and / or a branched chain amino acid.
  • the composition according to (3), wherein the seaweed extract is an extract from brown algae.
  • the composition according to (4), wherein the brown algae is black, arame, or scabbard.
  • composition according to (3) wherein the branched chain amino acid is valine, leucine or isoleucine.
  • the composition according to any one of (7). (9) The composition according to any one of (1) to (8), further comprising glucosamine, methylsulfonylmethane, chondroitin sulfate, or lactobionic acid. (10) The composition according to any one of (1) to (9), further comprising citrulline.
  • Composition (12) The composition according to any one of (1) to (11), which is for a race animal. (13) The composition according to (12), wherein the race animal is a horse. (14) An animal feed container filled with the composition according to any one of (1) to (13). (15) The animal feed container according to (14), wherein the container has a syringe shape. (16) A method for enhancing endurance of an animal, comprising administering an effective amount of coenzyme Q10 to the animal. (17) A method for improving fatigue of an animal, comprising administering an effective amount of coenzyme Q10 to the animal. (18) Use of coenzyme Q10 for the manufacture of a medicament for use in endurance enhancement and / or fatigue improvement.
  • an animal nutrition composition having high absorbability, uniformly dispersed, endurance enhancing action and anti-fatigue action, a method for producing the composition, and a container capable of reliably supplying the composition are provided. be able to.
  • the animal nutrition composition of the present invention is particularly effective as a feed for animals for racing.
  • the present invention is advantageous in that it can provide a composition for use in increasing endurance and / or improving fatigue for use in animals, particularly racehorses.
  • FIG. 1 shows a treadmill used in the endurance test of the example.
  • FIG. 2 shows the syringe used in the syringe extrusion test of the example.
  • CoQ10 used in the present invention means a benzoquinone derivative having a methyl group at the 2-position, a methoxy group at the 5-position and the 6-position, and an isoprenoid side chain consisting of 10 isoprene units at the 3-position.
  • the CoQ10 of the present invention may be either a reduced type or an oxidized type. A mixture thereof may be used.
  • Oxidized CoQ10 is a compound represented by the general formula (1).
  • Reduced CoQ10 is a compound represented by general formula (2).
  • the origin and production method of CoQ10 used in the present invention are not limited as long as it is CoQ10 that can be taken or consumed as a medicine or food.
  • a commercially available product may be used, or a product produced by a known method may be used.
  • the content of CoQ10 is, for example, 1 to 25% by weight, preferably 1 to 20% by weight, more preferably 1 to 10% by weight, and further preferably 1 to 5% by weight. be able to.
  • CoQ10 is an oleophilic solid having a low melting point, and is poorly soluble in water and is known to have low absorbability in oral administration. For this reason, it can be used in a form that improves the stability of properties such as the dispersion stability of CoQ10 and the ability to prevent crystal precipitation and the bioabsorbability.
  • CoQ10 can be blended with animal protein, plant protein, or a hydrolyzate thereof. That is, CoQ10 can be used as a mixture of CoQ10 and animal protein or plant protein, or a hydrolyzate thereof.
  • animal proteins include chicken egg protein, milk protein, meat protein, and the like.
  • plant proteins include soy protein and soy peptide.
  • treated seeds eg, ground powder of seed, powder obtained from seed extract, etc.
  • CoQ10 can be blended with a vegetable protein, more preferably a soy protein or a hydrolyzate thereof, and more preferably a soy protein hydrolyzate.
  • the blending ratio of soybean protein and its hydrolyzate is 5 to 99.9%.
  • the weight ratio of CoQ10 to soy protein or a hydrolyzate thereof is 0.1 to 10, preferably 0.2 to 5, more preferably 0.2 to 0.00 when CoQ10 is 1. 5.
  • commercially available BIOQ10-SA manufactured by Mitsubishi Gas Chemical Co., Inc.
  • BIOQ10-SA manufactured by Mitsubishi Gas Chemical Co., Inc.
  • CoQ10 can be used as an inclusion body.
  • the inclusion treatment can be performed using cyclodextrin or the like.
  • the inclusion treatment can be performed according to a known method.
  • CoQ10 can be used as an emulsified composition.
  • the emulsified composition of CoQ10 can be prepared using a known emulsifier.
  • the emulsifier include starch.
  • the starch is not particularly limited.
  • starch such as corn, straw corn, wheat, rice, beans, potato, sweet potato, tapioca, etc., or processed starch obtained by subjecting these starches to physical or chemical treatment (wet Heat-treated starch, starch hydrolyzate, etc.), and modified starch is preferred.
  • the weight ratio of CoQ10 to starch is 0.1 to 10, preferably 0.5 to 5, where CoQ10 is 1.
  • the emulsification treatment can be performed according to a known method.
  • As an emulsified composition of CoQ10 for example, a commercially available MGC PureSorb Q10 (manufactured by Mitsubishi Gas Chemical) can be used.
  • CoQ10 can be adsorbed and dispersed in starch particles in order to improve bioabsorbability.
  • the amount of starch particles is 5 to 99.9%.
  • cyclodextrin inclusion or emulsification treatment is also possible. That is, CoQ10 can be used as a mixture of CoQ10 and starch, or can be used as an inclusion body or an emulsified composition.
  • CoQ10 when used as an emulsified composition, for example, CoQ10 is dissolved in a sucrose fatty acid ester such as sucrose acetate isobutyrate, a medium chain fatty acid ester or the like as an oil phase component, and a polyhydric alcohol and an emulsifier are added. And can be emulsified.
  • a sucrose fatty acid ester such as sucrose acetate isobutyrate, a medium chain fatty acid ester or the like as an oil phase component
  • a polyhydric alcohol and an emulsifier are added.
  • a polyhydric alcohol and an emulsifier are added.
  • a polyhydric alcohol and an emulsifier are added.
  • a polyhydric alcohol and an emulsifier are added.
  • a polyhydric alcohol and an emulsifier are added.
  • a polyhydric alcohol and an emulsifier are added.
  • a polyhydric alcohol and an emulsifier
  • the drink containing Coenzyme Q10 can enhance endurance. Therefore, Coenzyme Q10 can be used in a composition for use in enhancing endurance and / or improving fatigue. Although not bound by the following theory, it is considered that coenzyme Q10 promotes energy production in the cells and compensates for the lack of energy, thereby realizing increased endurance and improved fatigue.
  • “endurance” means the ability to perform physical activity continuously. For example, the ability of the racehorse to ensure sufficient physical strength for the final game to the middle of the race, the ability to demonstrate the maximum ability for a longer time in the final game, and the like.
  • the composition used for enhancing endurance means a composition exhibiting an action of enhancing endurance.
  • the composition for use in endurance enhancement can be used as an endurance enhancer.
  • fatigue means a quantitative or qualitative decrease in work ability when physical or mental work is continuously performed. For example, there is a decrease in concentration after running on a racehorse. Delayed recovery from fatigue hinders efficient training.
  • the composition used for improving fatigue means a composition exhibiting an action of reducing the fatigue state, an action of restoring the fatigue state, or an action of preventing fatigue.
  • the composition for use in improving fatigue can be used as a fatigue improving agent.
  • the fatigue-improving agent according to the present invention can particularly improve fatigue caused by continuously performing physical work.
  • composition according to the present invention can be preferably used as an endurance enhancer.
  • composition according to the present invention can be used as a nutritional composition for animals.
  • composition according to the present invention can be used as a feed composition.
  • composition or the nutritional composition for animals according to the present invention may further contain a seaweed extract.
  • the seaweed extract used in the present invention may be an extract from seaweed, and is preferably extracted from brown algae and includes a component containing polyphenol phlorotannin.
  • brown algae include chrome, arame, and scabbard.
  • a commercially available seaweed extract may be used. Alternatively, it may be obtained by extraction from seaweed according to a known method.
  • composition according to the present invention or the nutritional composition for animals can further contain a branched chain amino acid.
  • the origin and production method of the branched chain amino acid used in the present invention are not limited as long as it is an amino acid that can be taken or edible as a medicine or food.
  • a commercially available product may be used. Or what was manufactured in accordance with the well-known method may be used.
  • Specific examples of branched chain amino acids include valine, leucine, and isoleucine.
  • the blending ratio of CoQ10, seaweed extract, and branched-chain amino acid is 0.1 to 1, preferably 0.2 to 0.8, more preferably seaweed extract by weight, where CoQ10 is 1. 0.4 to 0.6, and the branched chain amino acid has a weight of 0.05 to 0.5, preferably 0.1 to 0.5, more preferably 0.2 to 0. .3.
  • composition according to the present invention or the animal nutrition composition may further contain glucosamine, methylsulfonylmethane, chondroitin sulfate or lactobionic acid to strengthen the joint.
  • composition according to the present invention or the nutritional composition for animals can further contain citrulline known as a fatigue recovery component.
  • citrulline known as a fatigue recovery component.
  • it can be added as wild watermelon fruit juice containing a large amount of citrulline.
  • the composition according to the present invention or the nutritional composition for animals includes various nutrients, various vitamins (vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, etc.), various minerals, and dietary fiber as necessary.
  • Polyunsaturated fatty acids other nutrients (carotenoids such as ⁇ -carotene, lycopene, astaxanthin, carnitine, sesamin), dispersants, stabilizers such as emulsifiers, sweeteners, taste ingredients (citric acid, malic acid, etc.)
  • Flavor, royal jelly, propolis, agarics and the like can be blended. You may mix herbs such as peppermint, bergamot, camomile meal, lavender.
  • composition of the present invention or the nutritional composition for animals includes powders, powders, granules, soft capsules, hard capsules, tablets, tablets, chewable tablets, quick-disintegrating tablets, syrups, solutions, suspensions, suppositories, ointments. , Creams, gels, adhesives, inhalants, injections and the like. Preferably, it can be set as a liquid agent.
  • composition of the present invention or animal nutrition composition When used as a powder, it is produced by drying the composition of the present invention or animal nutrition composition by a method such as freeze-drying, spray-drying, or heat-drying. be able to.
  • the powder thus obtained can be further dissolved in water or the like to form a liquid agent.
  • Additives that can be used for formulation include animal oils such as soybean oil, safflower oil, olive oil, germ oil, sunflower oil, beef tallow, sardine oil, polyethylene glycol, propylene glycol, glycerin, sorbitol, etc.
  • Surfactant such as polyhydric alcohol, sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, purified water, lactose, starch, crystalline cellulose, D-mannitol, lecithin, gum arabic, sorbitol solution, sugar Examples include excipients such as liquids, sweeteners, colorants, pH adjusters, and fragrances. The liquid preparation may be dissolved or suspended in water or other appropriate medium when taken. Tablets and granules may be coated by a known method.
  • composition or the nutritional composition for animals according to the present invention can be used for various animals, but can be preferably used for competing animals.
  • competing animals include horses, dogs, chickens, pigeons, camels, and pigs, with horses being preferred.
  • Examples of the method for administering the composition of the present invention or the nutritional composition for animals to an animal include a method of giving it to an animal as it is, a method of giving it by mixing with feed, a method of giving it by dispersing it in a solution such as water, and the like.
  • the administration of the composition of the present invention or the nutritional composition for animals to animals may be oral administration or parenteral administration, but is preferably oral administration.
  • the container In order to give an animal the composition of the present invention or the nutritional composition for animals, it is preferable to fill the container with the composition. When filling, it is preferable that the composition is shaped to match the container.
  • the container used in the present invention is not required to leak the contents to the outside, and preferably has a shape that is squeezed or pushed out by human power when given to an animal such as a horse. In particular, it is preferable to use a syringe-shaped container as shown in FIG.
  • a syringe-shaped container having a cap 1 at the syringe outlet, a protrusion 2 matched to the outlet shape at the push-out portion of the syringe, and a protrusion 3 on the outer tube portion so that the push-out portion does not come out.
  • the cap structure of 1 the leakage from the container can be prevented.
  • the protrusion 2 can be taken out without leaving the contents of the syringe.
  • the protrusion 3 has a structure that prevents the cylinder portion from being directed out of the syringe, and has an effect of preventing an accident due to detachment during transportation and use.
  • the inner volume of the syringe can be 0.1 to 2000 ml depending on the purpose, preferably 25 to 100 ml.
  • the material of the container is not particularly limited and can be used. Metal, glass, plastic and the like can be used, and these can be used alone or in accordance with the place.
  • CoQ10 which is an active ingredient of the composition of the present invention or the nutritional composition for animals, can be used safely for animals.
  • the dosage of the active ingredient according to the present invention can be determined as appropriate.
  • the active ingredient according to the present invention can be administered in the range of 0.5 to 5 mg / kg body weight, preferably 1.5 to 2 mg / kg body weight per day.
  • the total dose may be given at once, or may be given in about 2 to 3 times.
  • the timing of administration is not particularly limited, but daily from about 1 to 2 weeks before physical or mental work (for example, race if a racehorse), and further physical or mental work (for example, race)
  • physical or mental work for example, race if a racehorse
  • race for horses, it is preferable to administer for about a week after the race.
  • a method for enhancing endurance of an animal comprising administering an effective amount of coenzyme Q10 to the animal.
  • a method for improving animal fatigue comprising administering to an animal an effective amount of coenzyme Q10.
  • the above-described composition according to the present invention can be used.
  • medical practice can be excluded from these methods.
  • humans can be excluded from animals.
  • coenzyme Q10 for producing a drug for use in endurance enhancement and / or fatigue improvement.
  • the above-mentioned composition according to the present invention can be used as a drug for use in this use for endurance enhancement and / or fatigue improvement.
  • coenzyme Q10 for producing a composition for use in endurance enhancement and / or fatigue improvement.
  • the composition used for endurance enhancement and / or fatigue improvement used in this use the above-described composition according to the present invention can be used.
  • a method for producing a composition for use in enhancing endurance and / or improving fatigue characterized by comprising coenzyme Q10.
  • composition comprising coenzyme Q10 for use in enhancing endurance, wherein coenzyme Q10 is used as a mixture with soy protein or a hydrolyzate thereof.
  • a composition is provided.
  • composition comprising coenzyme Q10 for use in enhancing endurance, wherein coenzyme Q10 is used as an emulsified composition.
  • a composition for a veterinary animal for use in enhancing endurance comprising coenzyme Q10, wherein the coenzyme Q10 comprises soy protein or a hydrolyzate thereof.
  • a composition for use as a mixture of is provided.
  • the racing animal is preferably a horse.
  • a composition for a veterinary animal for running comprising coenzyme Q10, wherein coenzyme Q10 is used as an emulsified composition.
  • the racing animal is preferably a horse.
  • Example 1 80 g of CoQ10 powder (Mitsubishi Gas Chemical Co., Ltd.) and 20 g of soy protein hydrolyzate (Nisshin Oilio Co., Ltd.) were placed in a plastic bag and mixed. This is designated as water-soluble CoQ10 (soy protein).
  • This water-soluble CoQ10 (soy protein) corresponds to BIOQ10-SA (manufactured by Mitsubishi Gas Chemical).
  • the following composition 100g was mix
  • ⁇ Drink agent (Solution A)> Water-soluble CoQ10 (soy protein) 5g Glucosamine 5g Methylsulfonylmethane 3g Chondroitin sulfate 0.5g Hyaluronic acid 0.2g Lactobionic acid 2g Seaweed extract (cyanol) 2g Citric acid 0.5g Leucine 0.5g Isoleucine 0.3g Valine 0.3g NaCl 0.5g Vitamin E 5g 20g of granulated sugar Wild watermelon juice 50.2g Water balance
  • Example 2 40 g of CoQ10 powder (manufactured by Mitsubishi Gas Chemical Co., Inc.), 40 g of starch particles, 15 g of dextrin, and 5 g of glycerin were put in a homogenizer and heated to 60 ° C. to carry out an emulsification treatment. This is designated as water-soluble CoQ10 (starch).
  • the water-soluble CoQ10 (starch) corresponds to MGC PureSorb Q10 (manufactured by Mitsubishi Gas Chemical).
  • a uniform solution B could be prepared.
  • Example 3 When CoQ10 powder (manufactured by Mitsubishi Gas Chemical Co., Inc.) was used and 100 g of the following composition was prepared, CoQ10 was separated and did not form a uniform solution.
  • ⁇ Drink agent> CoQ10 4g Glucosamine 5g Methylsulfonylmethane 3g Chondroitin sulfate 0.5g Hyaluronic acid 0.2g Lactobionic acid 2g Seaweed extract (cyanol) 2g Citric acid 0.5g Leucine 0.5g Isoleucine 0.3g Valine 0.3g NaCl 0.5g Vitamin E 5g 20g of granulated sugar Wild watermelon juice 50.2g Water balance
  • Example 4 Powders could be produced by freeze-drying the solutions prepared in Examples 1 and 2.
  • Example 5 By re-adding 100 ml of water to 0.1 g of the powder obtained in Example 4, a uniform solution could be made.
  • Example 6 Using protein as a thickener, 100 g of the following composition was blended by a usual method to prepare a uniform solution C.
  • Example 7 Using water-soluble CoQ10 (starch), 100 g of the following composition was blended by a usual method. As a result, a uniform solution D could be prepared.
  • Water-soluble CoQ10 (starch) 35g Glucosamine 5g Methylsulfonylmethane 3g Chondroitin sulfate 0.5g Hyaluronic acid 0.2g Lactobionic acid 2g Seaweed extract (cyanol) 2g Citric acid 0.5g Leucine 0.5g Isoleucine 0.3g Valine 0.3g NaCl 0.5g Vitamin E 3g Granulated sugar 15g Wild watermelon juice 32.2g Water balance
  • Bioabsorbability test The bioabsorbability of the water-soluble CoQ10 prepared in Examples 1 and 2 was confirmed. Feeding method For 8-week-old SD rats (male, 3 animals per group, body weight 250-300 g), each water-soluble CoQ10 prepared in Examples 1 and 2 and normal CoQ10 were added at 100 mg / kg as CoQ10 amount. After orally forcibly ingesting so as to give a rat weight, blood was collected from the tail vein using a heparin-added vacuum blood collection tube 3 hours after administration, and plasma was separated.
  • Table 1 below shows the results of the absorptivity test in rats for each of the water-soluble CoQ10 prepared in Examples 1 and 2 and normal CoQ10 (average value of two animals). It was found that bioabsorbability was improved by using the water-soluble CoQ10 of the present invention.
  • Test Method Male 6-week-old of SPF-ICR mouse (purchased from Charles River Japan Co., Ltd.) was used. The mice were bred in a breeding room set at room temperature: 23 ⁇ 2 ° C., humidity: 55 ⁇ 6%, and lighted for 12 hours and turned off for 12 hours until the test was completed after arrival. Three cages per cage are housed in a polycarbonate case (Toyo Riko Co., Ltd.) with a floor covering for laboratory animals (White Flakes, Nippon Charles River Co., Ltd.), and a steel stand (Nihon Cage Co., Ltd.). Arranged above and reared.
  • mice solid feed MF Oriental Yeast Co., Ltd.
  • tap water were freely ingested.
  • Fig. 1 multiple treadmill system TMS-4, Merquest
  • 4 groups were prepared with 3 animals per group.
  • Endurance measurement was performed 30 minutes after oral administration, and was performed before administration, on the fifth day of administration, on the 12th day of administration, and on the 19th day of administration. Specifically, forced running (inclination 10 degrees, speed 20 m / min) is performed using a treadmill. After a while, the mouse gets tired and rides on the stimulation grid from the treadmill. Usually, the mouse escaped from the stimulation grid, but after forced running, the time from fatigue to fatigue from stopping on the stimulation grid for 1 minute was measured.
  • the mouse that took the drink prepared in Example 2 was 1.5 times to 5 times longer than the mouse that took the sample 1 before it escaped from the stimulation grid for 1 minute. From this, it was found that the drink using CoQ10 can enhance endurance.
  • the animal nutrition composition of the present invention is particularly effective as a feed for racing animals.
  • competing animals include horses, dogs, chickens, pigeons, camels and the like, which can be suitably used in the field of horses.

Abstract

Le but de la présente invention est de produire une composition destinée à être utilisée en vue de créer une endurance et/ou de soulager la fatigue. La présente invention concerne une composition comprenant la coenzyme Q10, notamment une coenzyme Q10, un extrait d'algues et un acide aminé à chaîne ramifiée.
PCT/JP2012/059594 2011-04-08 2012-04-06 Composition de nutriments pour animaux WO2012137953A1 (fr)

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JP2011-086634 2011-04-08
JP2011086634 2011-04-08
JP2011176677A JP2014131961A (ja) 2011-04-08 2011-08-12 動物用栄養組成物
JP2011-176677 2011-08-12

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KR102135295B1 (ko) * 2018-05-10 2020-07-17 한국식품연구원 넓패 추출물을 유효성분으로 하는 근지구력 증강용 조성물
JP7410654B2 (ja) * 2019-05-17 2024-01-10 サンエイ糖化株式会社 アミノ酸成分含有飲食組成物、アミノ酸成分の不快味マスキング剤及びアミノ酸成分に由来する不快味を改善する方法
KR102241762B1 (ko) * 2020-04-21 2021-04-19 한국식품연구원 넓패 추출물을 유효성분으로 하는 우울증 또는 스트레스 개선용 조성물 및 넓패 추출물을 유효성분으로 하는 조성물

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