WO2012090058A1 - Dispositif applicateur de liquides médicaux - Google Patents

Dispositif applicateur de liquides médicaux Download PDF

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Publication number
WO2012090058A1
WO2012090058A1 PCT/IB2011/003166 IB2011003166W WO2012090058A1 WO 2012090058 A1 WO2012090058 A1 WO 2012090058A1 IB 2011003166 W IB2011003166 W IB 2011003166W WO 2012090058 A1 WO2012090058 A1 WO 2012090058A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
metering
bearing
fitting tube
tube
Prior art date
Application number
PCT/IB2011/003166
Other languages
English (en)
Portuguese (pt)
Inventor
Esteban MANZIONI
Original Assignee
Denver Farma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denver Farma S.A. filed Critical Denver Farma S.A.
Publication of WO2012090058A1 publication Critical patent/WO2012090058A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

Definitions

  • the present invention relates to the medical field and medical liquid injector devices or applicators, and more particularly relates to a disposable pen-shaped insulin applicator that allows selectively delivering metered doses of medicament.
  • injection applicator devices In the field of medicinal self-applicators, more specifically in insulin and human growth hormone applications, injection applicator devices have been developed that can be manipulated by diabetic and growth-impaired patients, respectively.
  • Type I diabetes patients formerly known as juvenile or insulin-dependent diabetes, have a total dependence on insulin injections or periodic use of insulin pumps, as these patients' pancreas cannot secrete insulin by their own means. Because of this, the development and development of insulin delivery devices has been started so that they can be manipulated daily by sick patients.
  • applicators have been developed in which it is possible to manually adjust the amount of medicine to be applied.
  • a type of pen or pen insulin applicator is described, so that the medicine can be transported discreetly and comfortably, which has a cartridge mounted inside the applicator, where the medicine is deposited, presenting This cartridge is a piston that moves in an axial direction causing the medicine to exit through the needle.
  • CONFIRMATION COPY It is shifted to an initial position, and shortly after adjusting the dose and pressing a switch button that causes the piston to advance rapidly into the cartridge, the drug is delivered.
  • this medication delivery device has three mechanisms that work in tandem with each other, allowing rotation of the switch knob in either direction, increasing or decreasing the dose to be administered to the patient. Due to the number of mechanisms, grooved housings, retaining springs, and the large number of mechanical parts that interact with each rotation of the knob, there is a greater likelihood of rupture, with the ability to discard the device once used. , because of the great cost involved in building one of them.
  • the safety and hygiene rules specify that once the medicine is injected the needle must be discarded and that once the medicine is completely finished inside the cartridge it is necessary to discard the injector or the applicator device. This would imply a high cost for injectors composed of a large number of mechanical parts.
  • this applicator device comprises an axially movable drive and metering mechanism to contact the plunger and push the liquid in the direction of injection, and is also operable for the user to adjust the mechanism so that when actuated inject a metered amount of this liquid.
  • This applicator device includes a graduated metering socket, axially disposed within that housing, which has an outer surface connected in rotation with an inner surface of the same housing by a helical sliding coupling; a thrust fitting tube disposed axially within that metering fitting tube, having a faceted inner and outer surface and including a slidably coupled thread on an inner thread of the housing; an axially disposed inner key piece mounted within that slidingly thrust fitting pipe, and this inner key piece having a faceted outer surface that locks rotation with the faceted inner surface of the pusher fitting tube; a first clutch bearing disposed between a proximal end of the inner key piece and a proximal end of the metering socket tube, such proximal ends of the metering socket tube and inner key piece being coupled together; and a drive button coupled to the first clutch bearing.
  • Figure 1 shows a perspective view of the medical liquid dispensing device, such as insulin, relating to the present invention
  • Figure 2 shows a cross-sectional side view of the distal end of the applicator device of Figure 1;
  • Figure 3 shows a sectional side view of an average portion of the applicator device of Figure 1;
  • Fig. 4 shows a sectional side view of the proximal end of the applicator device of Fig. 1;
  • Fig. 5 shows a perspective view of a lower housing from one side of the applicator device of Fig. 1;
  • Fig. 6 shows a perspective view of the lower housing of Fig. 5 from the opposite end;
  • Figure 7 shows a perspective view of a bearing wedge from the lower end of the applicator device of Figure 1;
  • Figure 8 shows a perspective view of the bearing wedge of Figure 7 from the upper end of the applicator device of Figure 1;
  • Figure 9 shows a perspective view of the upper housing of the applicator device of Figure 1
  • Fig. 10 shows a perspective view of the upper housing of the applicator device of Fig. 1 seen from the other side;
  • Figure 11 shows a perspective view of a second clutch bearing or middle bearing of the applicator device of Figure 1;
  • Fig. 12 shows a perspective view of a separator of the applicator device of Fig. 1;
  • Figure 13 shows a perspective view of a metering fitting tube from the lower end of the applicator device of Figure 1;
  • Fig. 14 shows a side view of the metering fitting tube of Fig. 13;
  • Fig. 15 shows a perspective view of the metering fitting tube of Fig. 13 from the upper end of the applicator device of Fig. 1;
  • Figure 16 shows a perspective view of an inner threaded inner part of the applicator device of Figure 1;
  • Figure 17 shows a perspective view of a pusher fitting tube from the lower end of the applicator device of Figure 1;
  • Fig. 18 shows a perspective view of the pusher fitting tube of Fig. 17 from the upper end of the applicator device of Fig. 1;
  • Fig. 19 shows a perspective view of an interior key from the lower end of the applicator device of Fig. 1;
  • Fig. 20 shows a perspective view of the inner key of Fig. 19 from the upper end of the applicator device of Fig. 1;
  • Fig. 21 shows a perspective view of an intermediate key from the lower end of the applicator device of Fig. 1;
  • Figure 22 shows a perspective view of an upper bearing or first bearing from a lower end of the applicator device of Figure 1;
  • Fig. 23 shows a perspective view of the upper bearing of Fig. 22 from an upper end of the applicator device of Fig. 1;
  • Fig. 24 shows a perspective view of a switch button from the lower end of the applicator device of Fig. 1;
  • Figure 25 shows a perspective view of a lock piece from the lower end of the applicator device of Figure 1;
  • Figure 26 shows a perspective view of that lock of Figure 25 from the upper end of the applicator device of Figure 1, and
  • Fig. 27 is a cross-sectional view of the applicator of Fig.
  • the invention consists of a medical liquid applicator device 1, preferably insulin, or other medicaments, such as the administration of human growth hormone, the device being constructed so that it can be used. self-injecting by the patients themselves.
  • device 1 is composed of an outer shell divided into a lower shell 2 and an upper shell 3, relative to the distal end and proximal end of device 1, respectively.
  • three side sectional figures of the device numbered 2, 3 and 4 are shown. This further facilitates the understanding of the structure of the device. device and, subsequently, the functional explanation of actuation and dosing.
  • the lower casing 2 as shown in Figures 5 and 6, consists of a cylindrical body, preferably made of polypropylene, which has a rounded-edge window 4 which allows external visual access to the amount of drug deposited in the cartridge. 5, see Figure 2, provided with a plunger 6 intended to be driven to expel the medical liquid out of the cartridge 5 via an injection needle that connects to a nozzle 7.
  • the cartridge is made of some transparent material, such as glass, and is contained within the lower housing 4 so that the amount of liquid present can be observed.
  • the lower housing 2 At the lower end of the lower housing 2 there is a lower thread 8, inside which the cartridge end 5 is housed with the needle nozzle 7.
  • the housing At the same time, has a perimeter flap 9 next to the lower thread 8 where The flap serves to retain a cap 10 which protects the needle nozzle 7.
  • both the needle nozzle 7, the cap 10 and the cartridge 5 with the plunger 6 may be of any shape as long as they can be coupled to the lower housing 2, either physically, aesthetically and / or functionally; for example, the cap may be the same as a pen having internal slots so that it is retained against the perimeter flap 9 of the lower housing 2.
  • the bearing wedge 13 In an average portion of device 1, more specifically located within, between the carcasses 2 and 3, there is a bearing wedge 13, best shown in Figures 7 and 8.
  • the bearing wedge 13 also has a cylindrical shape. and preferably made of nylon.
  • the wedge 13 has at a lower end I a shallow cutout 14, "U" shaped coincident with the upper edge of the casing window 4, so as not to prevent visual access to the liquid content in the cartridge 5 deposited within that lower end I.
  • In an average section of the cutout 14 there are a pair of cutout grooves 15, coinciding with the inner ribs 11 of the lower housing 2.
  • the middle flap is larger than the other two, with lower 16 and upper 18 having the same dimensions;
  • the middle flap 17 divides the ends I and S of the wedge 13.
  • the lower perimeter flap 16 is projected radially outwardly from the surface of the wedge 13 so that it is housed in the inner seat 12.
  • the inner ribs 11, coinciding with the cutout slots 15, and the lower perimeter flap 16 housed in the inner slots 12 of the lower housing 2 provide a union between the lower housing 2 and the wedge 13, which is at the same time joined to the upper housing 3 as will be detailed but below.
  • the upper perimeter flap 17 extends outwards, dividing the lower carcasses 2 and upper 3, as shown in Figure 1.
  • the upper perimeter flap 18 is housed in a perimeter seat 19, located inwardly at the lower end of the upper housing 3, so that the two carcasses are held together by the bearing wedge 13.
  • the upper casing 3 has a lower end 20 in the form of a cutout, causing the middle perimeter flap 17 of the wedge 13 to extend outwardly of the device 1.
  • a decrease in inner diameter is produced by forming a central hole 21 and adjacent to that hole 21, an inner toothed surface 22, where a middle bearing or second bearing is housed.
  • clutch gear 23 The second clutch bearing 23, shown in figure 11, preferably constructed of acetal resin, has an elastic tooth set 24 that locks against the inner toothed surface 22 in a preferably counterclockwise direction of rotation.
  • Such a bearing 23 has a faceted hole 25, which is called a facet any outer or inner surface which has a morphology similar to that of a circumference but which additionally has a cut or more than one cut or plane or face on that surface. and such surfaces being in contact, i.e.
  • the bearing 23 is located, as mentioned above, inside the upper end S of the bearing wedge 13, adjacent to the center hole 21. Opposite to this hole 21, still inside the bearing wedge 13, is a separator 26, as illustrated in figure 12.
  • the separator 26 consists of a disc, preferably made of polypropylene, which has an outer edge 27, and an inner edge 28 that defines a center of impact or support 29.
  • the outer edge 27 is in contact with the inner walls of the interior. cartridge 5, which in turn rests within the lower end I of the bearing wedge, as stated above.
  • the outer edge closes on the walls of the cartridge 5 and contacts the plunger 6 so as to move axially together, the plunger 6 being hermetically sealed against the inner walls of the cartridge 5, preventing medical liquid drain towards the separator 26.
  • device 1 can be analyzed as an axially movable drive and metering mechanism to contact this plunger 6 and push the liquid in the direction of injection, and is also operable for the user to adjust the delivery mechanism. so that when triggered, inject a metered amount of that liquid.
  • Such drive and metering mechanism further comprises a graduated metering socket 30 axially disposed within the upper housing 3, having an outer surface 31 connected in rotation with an inner surface 32 of that upper housing 3 via a helical sliding coupling.
  • a helical sliding coupling between the metering socket 30 and the upper housing 3 is formed by a helical fillet 33 on the outside of that socket 30, and a helical groove 34 in that upper housing 3.
  • Metering tube 30, as shown in Figures 13, 14 and 15, is also an analog visual indicator, since on the outer surface 31 is printed a plurality of numbers 35, part of which is illustrated in Figure 14 only. , which assign a volume value to the amount of drug to be administered. Such numbers 35 can be seen from an outer window 36 in the upper housing 3.
  • This socket 30 has a proximal end 37 extending beyond the outer diameter of socket 30 and is comprised of a hand gauge 38 extending beyond upper housing 3 so that the user can pick it up. by rotating this socket 30.
  • Such socket 30 has within that proximal end 37 an inner tooth 39 and at a smaller diameter meter 30 has a inner seat 40 which specifically does not belong to the proximal end 37.
  • the upper shell 3 as described so far with the aid of figures 9 and 10, has an outer surface 41 of polypropylene as well as the entire upper shell 3. At the lower end of this shell, near the lower perimeter seat, there is a a pair of ribs 42 resting on an inner seat 43 consisting of a decrease in the inner diameter of the upper housing 3.
  • This pair of ribs 42 is housed in a pair of outer slots 44 belonging to an inner piece 45 with internal thread, preferably made of nylon, and illustrated in Figure 16; such part 45 of upper housing 3 is retained within that upper housing 3.
  • Part 45 further has a lower end 46 defined by a decrease in diameter of that part 45, the lower end 46 being within the upper end S of the bearing wedge. 13 adjacent to second bearing 23.
  • Inner part 45 is retained in upper housing 3.
  • Part 45 has a threaded hole 47, inside which is housed a pusher fitting tube 48, axially disposed within said metering fitting tube 30, said pusher fitting tube 48 having a faceted inner surface 49 and a faceted outer surface 50, which includes a thread 51 slidably coupled with that threaded surface of the threaded hole 47 of the inner threaded part 45.
  • the faceted outer surface 50 of that pusher is coupled to the rotation direction within the faceted central hole 25 of this second bearing 23
  • Booster fitting tube 48 illustrated in the figures
  • the thread 51 is preferably a double thread to provide greater rotation accuracy.
  • Such socket 48 has at the distal end an impact tip or pusher 52 and more particularly its surface. outer section has a smooth section 53.
  • the socket 48 when rotating under the drive mechanism, as explained below, slides forward and causes the impact point 52 to strike the center of impact. 29 of the separator 26 by displacing it and thereby also moving the plunger 6 into the cartridge 5, ejecting the medical liquid through the needle nozzle 7.
  • a step is defined, or top surface 85, which operates as top for initial positioning when assembling the entire assembly.
  • An inner key piece 54 is arranged axially within said pusher fitting tube 48, slidably mounted therein and the inner key piece 54 having a faceted outer surface 55 which it locks the rotation with that faceted inner surface 49 of the drive tube 48.
  • Such inner key 54 is preferably made of acetal resin, and has at the distal end a pair of elastic flaps 56, the operation of which will be described below.
  • this inner key 54 may preferably be hollow, so as to represent less weight when axially moving.
  • the proximal end of this key 54 is comprised of a base 57 of greater diameter and breadth than the rest of the key 54.
  • This base 57 has an internal tooth 58.
  • a first set of ribs outside this base 57 is a first set of ribs.
  • radial members 59 extending from the regular diameter of the interior key 54 to a first base edge 60, and a second set of radial ribs 61 extending from the first edge 60 to a second edge 62.
  • a cylindrical shaped intermediate key piece 63 preferably made of acetal resin and arranged axially within that pusher socket 48 and over the inner key part 54, which is inner intermediate key piece 63 and that pusher socket 48 coupled together with axial freedom of movement but prevented from rotating.
  • This coupling is carried out between a faceted outer surface 64 of the key 63 and that faceted inner surface 49 of the pusher socket 48.
  • the intermediate key 63 has a faceted inner surface 65 which mates with the faceted outer surface 55. of the inner key.
  • That faceted inner surface 65 has at the distal end a pair of axial grooves 66, within which the elastic tabs 56 of the inner key are housed, preventing that intermediate key 63 from escaping from the perimeter of the inner key 54 causing decoupling; that is, thus the intermediate key 63 is retained by the inner key 54, but with free axial movement over and along the key 54.
  • a first clutch bearing 67 which at the same time is at the proximal end 37 of that metering socket 30, such proximal end 37 and such base 57 couplable with each other.
  • That first clutch bearing 67 shown in Figures 22 and 23 is preferably made of acetal resin and has a first set of spring teeth 68 and a second set of spring teeth 69, where the first set of spring teeth 68 lock. rotation direction with the inner tooth 39 of the proximal end 37 of the metering socket 30, and where the second set of spring teeth 69 lock in the direction of rotation with the inner tooth 58 of the base 57 of the inner key piece 54.
  • This first set of spring teeth 68 has a central hole 70 which in turn An inner perimeter seat 71 is housed within that hole 70.
  • a distal end 72 is housed 72 of a switch button 73 shown in Figure 24. This button may be of polypropylene or any other type of plastics material.
  • Button 73 has a proximal end 74 of larger diameter and cylindrical shape, and this distal end 72 is also cylindrical in shape, but with a much smaller diameter than the proximal one.
  • Such distal end 72 has a perimeter flap 75 housing on that inner perimeter seat 71 of first bearing 67 so that such switch button 73 rotates uncontrollably on that central bearing hole 70.
  • a locking piece 76 is telescopically placed between the metering fitting tube 30 and the pusher fitting tube 48.
  • Such locking piece 76 is preferably fabricated. polypropylene and, as shown in Figures 25 and 26, this locking part has a cylindrical shape and two well-defined ends, consisting of a distal end 77 in a disc of larger outside diameter than that of the lock body 76. Such an end 77 in disc shape, it rests on the inner seat 43 of the upper housing 3 so that it is retained in that upper housing 3.
  • the distal end 77 has a pair of side indentations 78 coincident with the a pair of ribs 42 of the interior of the upper housing 3, ensuring a fixed position of that lock 76 with respect to the upper housing 3, as mentioned above.
  • This locking piece 76 has a proximal end 79 consisting of a broken tab or broken disc of larger diameter 83 than that of the lock body 76, but of smaller diameter than that of the distal discoid end 77.
  • the patient takes the proximal end 37 of the metering fitting tube 30 to rotate it to adjust the desired dose.
  • Upper housing 3 has an arrow-shaped indicator 80 pointing to the number 35 corresponding to the dose of liquid to be administered.
  • the meter 30 By turning the meter 30 clockwise, it is moved axially outward with respect to the upper housing 3, thanks to the helical sliding coupling between the inner surface 32 of the upper housing 3 and the outer surface 31 of the socket 30, composed of such a coupling. , as has already been said, by the helical thread 33.
  • the metering socket 30 rotates clockwise and moves axially with the first bearing, or upper bearing 67, with the bearing having a perimeter profile.
  • 81 is seated in an inner groove 82 of the proximal end 37 of the metering fitting tube 30, the fitting of such fitting tube 30 and the bearing 67 and, consequently, the pushbutton 73, whose distal end 72 is housed within the hole. 70 of the upper bearing 67.
  • the first set of spring teeth 68 mates with the inner tooth 39 of the meter 30, causing the second set of teeth 69 to fall in the wrong direction.
  • internal toothing 58 causing a characteristic tooth noise that indicates to the user that a dosage grading is taking place.
  • the inner key 54 By axially dragging the inner key 54, it moves axially with respect to the intermediate key 63. In this movement it was taken into account that the inner key 54 could be offset from the intermediate key 63, i.e. that the outer surface 55 is no longer in contact with the inner surface 65 of the intermediate key 63 so that they cannot engage in rotation.
  • the elastic flaps 56 housed in the axial grooves 66 have been arranged so that the intermediate key 63 always has a portion mounted or coupled to the inner key 54.
  • lock 76 In the event of an overdose, which prevents the meter from being extracted from the upper housing 3 is lock 76, since, thanks to that lock 76, the proximal end 79 has the broken retaining disc 83, in the extreme case that a maximum axial retraction of the meter 30 with respect to the upper housing 3 such as broken disc 83 top with an inner disc seat 84 which has meter 30 inside.
  • Such locking piece 76 is axially retained in the housing thanks to its side indentations 78 of the distal end 77 topping the inner seat 43 of that upper housing 3. This ensures correct operation of the drive mechanism in extreme cases. dose.
  • the push-fit tube does not move axially when the inner key 54 for the reasons already exposed is moved between the intermediate key 63 and the inner key 54.
  • the medium bearing 23 is available in the remote case. for the pusher 48 to perform an unwanted rotation that causes it to recede. Such a bearing 23 is locked, preventing the return of the booster 48. Therefore, when a dose correction is desired by turning the meter 30 counterclockwise, the set of elastic teeth 24 rotates with respect to the inner toothed surface. 22 wedge of bearing 13, producing a characteristic noise that indicates to the user that a dose correction is taking place.
  • meter 30 When rotating in the other direction, meter 30 begins to fall axially while rotating counterclockwise. It is important to consider that the race that moves the meter 30 with the inner key 54 is proportional to the race that the piston 6 will perform inside the cartridge 5, but it is not the same race. This rotation-displacement ratio is defined thanks to the double thread 51 of the booster fitting tube 48.
  • the insulin or medicinal liquid containing the cartridge 5 is applied.
  • the inner key 54 is moved axially by a distance Z which is defined between the second base edge 62 and the inner seat 40, the second set of radial ribs is seated in the grooves of that seat 40, communicating the axial movement.
  • the meter 30, to move axially must rotate around the helical grooves 34 of the housing 3, it begins to rotate communicating such rotation to the interior key 54, thereby engaging the key 54 and the meter 30, rotating and descending together .
  • Turning the inner key 54 causes the intermediate key 63 to rotate and at the same time communicates it to the pusher fitting tube 48.
  • the booster fitting 48 rotates within the inner thread 45 which, as explained above, may be part of the housing or a fixed part of that housing. Thus, the booster moves axially as it rotates.
  • a socket 48 cannot be retracted even when the inner key turns at least a quarter turn at the time of dosing, causing the intermediate spanner 63 to rotate and that of the pusher 48.
  • the pusher socket pipe attempt to rotate, communicates the rotation to the middle bearing 23, and this Rolling prevents such movement, whereby the aforementioned structure does not rotate when adjusting the dose.
  • the inner key starts to rotate as already said, communicating the rotary movement to the intermediate key and this to the booster, which when turning and its outer surface 50, more particularly its thread 51, in contact with threaded hole 47 of internal thread 45, begins to move axially to the bottom.
  • Impact tip or pusher 52 contacts the center of impact 29 of separator 25 causing displacement thereof, and thanks to inner and outer edges 28, such separator causes displacement of plunger 6 within the cartridge.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif applicateur de liquides médicaux, comprenant un boîtier extérieur et une cartouche contenant le liquide, cette cartouche étant pourvue d'un piston destiné à être actionné en vue de l'expulsion du liquide vers l'extérieur de la cartouche, à travers une aiguille d'injection. Ce dispositif applicateur comprend un mécanisme d'actionnement et de dosage axialement mobile destiné à entrer en contact avec le piston et à pousser le liquide dans le sens d'injection, ce dispositif applicateur étant constitué par un tube de mesure gradué emboîtable situé dans le boîtier, un tube d'impulsion emboîtable situé dans le tube de mesure emboîtable, une pièce de clé intérieure située dans le tube d'impulsion emboîtable et coulissant dans le sens axial, mais bloquée lorsqu'il s'agit de tourner avec le tube d'impulsion emboîtable, un premier roulement d'embrayage entre la pièce de clé intérieure et le tube de mesure emboîtable, et un bouton d'actionnement accouplé au premier roulement d'embrayage.
PCT/IB2011/003166 2010-12-28 2011-12-28 Dispositif applicateur de liquides médicaux WO2012090058A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ARP100104975 AR079763A1 (es) 2010-12-28 2010-12-28 Dispositivo aplicador de liquidos medicinales
ARP20100104975 2010-12-28

Publications (1)

Publication Number Publication Date
WO2012090058A1 true WO2012090058A1 (fr) 2012-07-05

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2109690A (en) * 1981-02-12 1983-06-08 Robert Charles Turner Dose metering plunger devices for use with syringes
US4395921A (en) * 1981-06-26 1983-08-02 Scientific Manufacturing Industries, Inc. Adjustable volume liquid dispenser
US4592745A (en) * 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
EP0295075A1 (fr) * 1987-06-12 1988-12-14 Hypoguard (Uk) Limited Seringue à doses mesurées
BR9100415A (pt) * 1991-01-31 1992-09-08 Lilly Co Eli Dispositivo aperfeicoado para ajuste da dosagem de liquidos e seringa
US5688251A (en) * 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US6936032B1 (en) * 1999-08-05 2005-08-30 Becton, Dickinson And Company Medication delivery pen

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2109690A (en) * 1981-02-12 1983-06-08 Robert Charles Turner Dose metering plunger devices for use with syringes
US4395921A (en) * 1981-06-26 1983-08-02 Scientific Manufacturing Industries, Inc. Adjustable volume liquid dispenser
US4592745A (en) * 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
EP0295075A1 (fr) * 1987-06-12 1988-12-14 Hypoguard (Uk) Limited Seringue à doses mesurées
BR9100415A (pt) * 1991-01-31 1992-09-08 Lilly Co Eli Dispositivo aperfeicoado para ajuste da dosagem de liquidos e seringa
US5688251A (en) * 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US6936032B1 (en) * 1999-08-05 2005-08-30 Becton, Dickinson And Company Medication delivery pen

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Publication number Publication date
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