WO2012013472A1 - Dispositif de transport modulaire à micro-aiguille - Google Patents

Dispositif de transport modulaire à micro-aiguille Download PDF

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Publication number
WO2012013472A1
WO2012013472A1 PCT/EP2011/061547 EP2011061547W WO2012013472A1 WO 2012013472 A1 WO2012013472 A1 WO 2012013472A1 EP 2011061547 W EP2011061547 W EP 2011061547W WO 2012013472 A1 WO2012013472 A1 WO 2012013472A1
Authority
WO
WIPO (PCT)
Prior art keywords
microneedle
module
modular
transport
transport device
Prior art date
Application number
PCT/EP2011/061547
Other languages
German (de)
English (en)
Inventor
Kathrin Van Teeffelen
Original Assignee
Robert Bosch Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch Gmbh filed Critical Robert Bosch Gmbh
Priority to EP11730957.5A priority Critical patent/EP2598198A1/fr
Publication of WO2012013472A1 publication Critical patent/WO2012013472A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150267—Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm

Definitions

  • the present invention relates to a modular microneedle transport device.
  • DE 10 2006 028 781 A1 discloses a method for the production of porous micro-needles arranged on a silicon substrate in an array for the transdermal administration of medicaments.
  • the method includes forming a microneedle array having a plurality of microneedles on the front side of a semiconductor substrate rising from a support region of the semiconductor substrate, and partially porosifying the semiconductor substrate to form porous microneedles, the porosification starting from the front side of the semiconductor substrate and a porous one Reservoir is formed.
  • US 2008/0319392 A1 discloses a microneedle transport device having a reservoir for receiving a transport fluid, a needle assembly, each needle having a bore in fluid communication with the reservoir, a first actuator for driving the needles into the body, and withdrawing the needles from the needle Body and a second actuator, which pumps the transport fluid between the reservoir and the body through the needles, which can be designed bidirectional.
  • US 2009/0099522 A1 discloses a microneedle system with an analysis device.
  • WO 2005/015021 A1 discloses a method for producing a micromechanical component for fluidic applications and a micropump of a pump membrane made of a polysilicon layer.
  • Microneedle arrays comprising, for example, porous silicon micro-needles are generally used in the field of "transdermal drug delivery" as an extension of medicament patches, as a carrier of a vaccine or also for obtaining body fluid (so-called transdermal fluid) for diagnosis and analysis used by body parameters (eg glucose, lactate, ).
  • diabetes mellitus type 1 Millions of people around the world are suffering from illnesses that require long-term, almost constant medication. These include, for example, diabetes mellitus type 1.
  • a drug dosing system in this case an insulin pumping device, which delivers insulin to the human body, is particularly useful in this type 1, as well as the body gentle dosage of the human pancreas and thus long-term consequences can be reduced.
  • the drive unit, the power supply and the control of such known pumps are reused.
  • the patient merely replaces an insulin cartridge and the needle.
  • Refilling is more difficult, if not impossible, for particularly young or elderly patients.
  • the modular microneedle transport device defined in claim 1 has the advantage that the size (flat structure), costs (separation of disposable unit and reusable unit) and operability for the patient over known
  • the microneedle transport device according to the invention can be constructed extremely flat, that is, it is easy to hide under clothing and thus virtually invisible to an outside viewer.
  • the microneedle transport device has a preferred development on its underside, that is, where the microneedle device is provided, a patch, which the patient directly adheres to the skin.
  • it is designed so that the patient can handle the pump extremely easy, annoying refilling of the reservoir is eliminated.
  • microneedle transport device Due to the separation into a first module, which has the fluid reservoir, the microneedle device and the micropump device, and a second module, which has an actuator device and a battery-operated control device, only the inexpensive first module is discarded and then a replacement module with the second Module connected.
  • the micro-needle transport device according to the invention can be equipped with a higher comfort when the reservoir is made of a flexible plastic, who, as the reservoir is pumped over the injection time always empty, over the period of wear is getting smaller. Since the connection of the two modules requires only a mechanical attachment, but no electrical or fluidic connection, the handling is particularly easy for the patient and can avoid sterility problems.
  • a particularly preferred embodiment provides for positively locking or clipping the second module in a recess of the first module.
  • FIG. 1 a-e schematic cross-sectional views for explaining a
  • Fig. 2 shows an example of an application of the microneedle transport device according to
  • Fig. 3 is a schematic cross-sectional view for explaining another
  • Embodiment of the modular microneedle transport device according to the invention Embodiment of the modular microneedle transport device according to the invention.
  • Fig. 1 a-e show schematic cross-sectional views for explaining a
  • Embodiment of the modular microneedle transport device according to the invention Embodiment of the modular microneedle transport device according to the invention.
  • reference numeral 1 denotes a microneedle transport device in the form of an insulin pumping device with a round geometry.
  • the microneedle transport device 1 has a first module 20, which has a fluid reservoir 23 for receiving a transport fluid F, a microneedle device 22 and a micropump device 24 for pumping the transport fluid F from the fluid reservoir 23 via a micro-conduit means I into the microneedle device 22.
  • used in the first module 20 is a second module 10, which has an actuator device 10a and a battery-operated control device 10b. For reasons of simplification, the battery is not shown separately.
  • the micropump device 24 is a silicon pump chip known per se, which can suck in the transport fluid F in the form of insulin at inlets E and which can inject the transport fluid F via the microlube device I via the microneedle device 22 under the skin of a patient.
  • the microneedle device 22 is, for example, an arrangement of porous silicon needles 25, which rise on a silicon substrate.
  • an adhesive plaster device 21 is provided, which in the present case is penetrated by the microneedles 25 and which allows easy mounting of the microneedle transport device 1 on the skin of the patient.
  • the adhesive plaster device 21 surrounds only the periphery of the microneedle device 22 on the underside U of the first module 20.
  • the locking device R consists of a circumferential groove N in the first module and a corresponding projection V in the second module (see Figure 1 d, e).
  • the second module 10 can thus be inserted into a recess 50 of the first module such that it bears in a form-fitting manner therein and forms a flush upper side O with the first module 20.
  • the second module 10 can apply pressure to the silicon pump chip 24 via the flexible outer wall, such as the first module 20, in a region where the silicon pump chip 24 has a pumping membrane.
  • This pressure P (see FIG. 1 e), which is expended, for example, via a plunger ST, permits actuation of the micropump in the form of the silicon pump chip 24.
  • the battery-operated control unit 10d for example, predetermines a permanently programmed time sequence via a control line 100 or can be actuated from the outside at the top O by a user set or program.
  • FIG. 1 c shows the fluid reservoir 23 for the transport fluid 1 1, which consists of a flexible plastic, a balloon-like behavior.
  • the size of the upper side O becomes smaller as the fill level of the fluid reservoir 23 decreases
  • reference symbol UP denotes a pressure actuation surface on which the plunger ST of the actuator device 10 a shown in FIG. 1 e acts in order to actuate the micropump 24.
  • Fig. 2 shows an example of an application of the microneedle transport device according to FIG. 1 to the human body.
  • FIG. 2 shows a comfortable type of insulin pump device described in connection with FIG. 1 a-e, in which a patient M sticks the microneedle transport device 1 onto his abdominal region with the aid of the adhesive paving device 21.
  • the microneedle transport device 1 according to FIG. 1 a-e can be made extremely flat and therefore offers a comfortable wearing feeling for the patient M, especially as it becomes smaller and smaller as the use increases due to the flexible nature of the fluid reservoir 23.
  • Fig. 3 shows a schematic cross-sectional view for explaining a further embodiment of the modular microneedle transport device according to the invention.
  • a rectangular geometry of the microneedle transport device 1 ' is provided, in which the second module 20' is displaced decentrally.
  • the adhesive patch 21 'and the array of microneedle 25' and fluid reservoir 23 ' have a proper geometry. As indicated in Figure 1 a and 3, can be due to the flexible property of
  • the microneedle device can have both a plurality of needles and only a single one Needle.
  • the fluid reservoir is not limited to the described flexible plastic, but may also be stiff. It may also have an inner coating so that the plastic does not give undefined substances to the transport fluid, for example insulin. Such an inner coating can be made, for example, from Teflon.
  • porous silicon microneedle device may alternatively be realized with a hollow needle device made of steel, plastic, silicon or other materials.
  • the filling of the fluid reservoir is expediently carried out in the manufacture of pumps by the manufacturer, but can also, if desired, be performed by the patient himself.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention concerne un dispositif de transport (1 ; 1') modulaire à micro-aiguille, doté d'un premier module (20 ; 20'), qui présente un réservoir à fluide (23 ; 23') destiné à recevoir un fluide de transport (F), d'un dispositif à micro-aiguille (22) et d'un dispositif à micropompe (24) pour le pompage du fluide de transport (F) du réservoir à fluide (23 ; 23') dans le dispositif à micro-aiguille (22) et/ou inversement ; d'un deuxième module (10; 10'), qui présente un dispositif d'actionnement (10a) et un dispositif commande (10b) à batterie ; le deuxième module (10 ; 10') peut être introduit dans un évidement (50) du première module (20 ; 20'). Le dispositif à micropompe (24), lorsque le deuxième module (10 ; 10') est installé, peut être actionné mécaniquement par le dispositif d'actionnement (10a) via une surface d'actionnement en pression (UP) réalisée dans l'évidement (50).
PCT/EP2011/061547 2010-07-30 2011-07-07 Dispositif de transport modulaire à micro-aiguille WO2012013472A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11730957.5A EP2598198A1 (fr) 2010-07-30 2011-07-07 Dispositif de transport modulaire à micro-aiguille

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010038733A DE102010038733A1 (de) 2010-07-30 2010-07-30 Modulare Mikronadel-Transportvorrichtung
DE102010038733.9 2010-07-30

Publications (1)

Publication Number Publication Date
WO2012013472A1 true WO2012013472A1 (fr) 2012-02-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/061547 WO2012013472A1 (fr) 2010-07-30 2011-07-07 Dispositif de transport modulaire à micro-aiguille

Country Status (3)

Country Link
EP (1) EP2598198A1 (fr)
DE (1) DE102010038733A1 (fr)
WO (1) WO2012013472A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018067289A1 (fr) 2016-10-05 2018-04-12 Exxonmobil Chemical Patents Inc. Métallocènes à encombrement stérique, synthèse et utilisation
US10807093B2 (en) 2016-02-05 2020-10-20 Katholieke Universiteit Leuven Microfluidic systems

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021112472A1 (de) 2021-05-12 2022-11-17 Dr. Ing. H.C. F. Porsche Aktiengesellschaft Verfahren zum Betreiben eines Kühlsystems eines Kraftfahrzeugs mit Kühlleistungsregelung

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US20030083618A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Transdermal transport device with an electrolytic actuator
WO2005015021A1 (fr) 2003-07-28 2005-02-17 Robert Bosch Gmbh Procede de production d'un composant micromecanique a utiliser de preference dans la fluidique, et micropompe pourvue d'une membrane constituee d'une couche de polysilicium
DE102005052039A1 (de) 2005-10-31 2007-05-03 Robert Bosch Gmbh Verfahren zur Herstellung einer Mikropumpe und durch dieses Verfahren hergestellte Mikropumpe
DE102006028781A1 (de) 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
US20090099522A1 (en) 2007-08-24 2009-04-16 Deka Products Limited Partneship Microneedle Systems and Apparatus

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CA2534726C (fr) * 2003-08-12 2015-04-28 Becton, Dickinson And Company Dispositif de perfusion de type timbre
EP2043728A2 (fr) * 2006-07-11 2009-04-08 Microchips, Inc. Dispositif multi-réservoirs à pompe pour dialyse, biodétection ou administration de substances

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US20030083618A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Transdermal transport device with an electrolytic actuator
US20080319392A1 (en) 2001-10-26 2008-12-25 Angel Aimee B Microneedle transport device
WO2005015021A1 (fr) 2003-07-28 2005-02-17 Robert Bosch Gmbh Procede de production d'un composant micromecanique a utiliser de preference dans la fluidique, et micropompe pourvue d'une membrane constituee d'une couche de polysilicium
DE102005052039A1 (de) 2005-10-31 2007-05-03 Robert Bosch Gmbh Verfahren zur Herstellung einer Mikropumpe und durch dieses Verfahren hergestellte Mikropumpe
DE102006028781A1 (de) 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
US20090099522A1 (en) 2007-08-24 2009-04-16 Deka Products Limited Partneship Microneedle Systems and Apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2598198A1 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10807093B2 (en) 2016-02-05 2020-10-20 Katholieke Universiteit Leuven Microfluidic systems
WO2018067289A1 (fr) 2016-10-05 2018-04-12 Exxonmobil Chemical Patents Inc. Métallocènes à encombrement stérique, synthèse et utilisation

Also Published As

Publication number Publication date
EP2598198A1 (fr) 2013-06-05
DE102010038733A1 (de) 2012-02-02

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