WO2012002863A1 - Mechanical component and method for surface hardening - Google Patents

Mechanical component and method for surface hardening Download PDF

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Publication number
WO2012002863A1
WO2012002863A1 PCT/SE2011/000094 SE2011000094W WO2012002863A1 WO 2012002863 A1 WO2012002863 A1 WO 2012002863A1 SE 2011000094 W SE2011000094 W SE 2011000094W WO 2012002863 A1 WO2012002863 A1 WO 2012002863A1
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WO
WIPO (PCT)
Prior art keywords
hardness
mechanical component
region
hrc
core
Prior art date
Application number
PCT/SE2011/000094
Other languages
English (en)
French (fr)
Inventor
Marco Burtchen
Original Assignee
Aktiebolaget Skf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Skf filed Critical Aktiebolaget Skf
Priority to JP2013518314A priority Critical patent/JP2013532233A/ja
Priority to US13/808,056 priority patent/US20130216856A1/en
Priority to CN2011800391476A priority patent/CN103080343A/zh
Priority to EP11801220.2A priority patent/EP2598662A1/en
Publication of WO2012002863A1 publication Critical patent/WO2012002863A1/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C21METALLURGY OF IRON
    • C21DMODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D1/00General methods or devices for heat treatment, e.g. annealing, hardening, quenching or tempering
    • C21D1/06Surface hardening
    • C21D1/09Surface hardening by direct application of electrical or wave energy; by particle radiation
    • C21D1/10Surface hardening by direct application of electrical or wave energy; by particle radiation by electric induction
    • CCHEMISTRY; METALLURGY
    • C21METALLURGY OF IRON
    • C21DMODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D1/00General methods or devices for heat treatment, e.g. annealing, hardening, quenching or tempering
    • C21D1/34Methods of heating
    • C21D1/42Induction heating
    • CCHEMISTRY; METALLURGY
    • C21METALLURGY OF IRON
    • C21DMODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D9/00Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22CALLOYS
    • C22C38/00Ferrous alloys, e.g. steel alloys
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22CALLOYS
    • C22C38/00Ferrous alloys, e.g. steel alloys
    • C22C38/002Ferrous alloys, e.g. steel alloys containing In, Mg, or other elements not provided for in one single group C22C38/001 - C22C38/60
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22CALLOYS
    • C22C38/00Ferrous alloys, e.g. steel alloys
    • C22C38/02Ferrous alloys, e.g. steel alloys containing silicon
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22CALLOYS
    • C22C38/00Ferrous alloys, e.g. steel alloys
    • C22C38/04Ferrous alloys, e.g. steel alloys containing manganese
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22CALLOYS
    • C22C38/00Ferrous alloys, e.g. steel alloys
    • C22C38/18Ferrous alloys, e.g. steel alloys containing chromium
    • CCHEMISTRY; METALLURGY
    • C21METALLURGY OF IRON
    • C21DMODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D2221/00Treating localised areas of an article
    • C21D2221/10Differential treatment of inner with respect to outer regions, e.g. core and periphery, respectively
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00Technologies related to metal processing
    • Y02P10/25Process efficiency
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/12All metal or with adjacent metals
    • Y10T428/12458All metal or with adjacent metals having composition, density, or hardness gradient

Definitions

  • the present invention concerns a mechanical component and a method for surface hardening at least one part of a surface of such a mechanical component.
  • Induction hardening is a heat treatment in which a metal component is heated to the ferrite/austenite transformation temperature or higher by induction heating and then quenched. The quenched metal undergoes a martensitic transformation, increasing the hardness and brittleness of the surface of a metal component. Induction hardening may be used to selectively harden areas of a mechanical component without affecting the properties of the component as a whole.
  • US patent no. 4 949 758 discloses a process for hardening the interior surface of a long (8-32 feet i.e. 244 - 975 cm), thin-walled (wall thickness 1/8 to 1 ⁇ 4 inch, i.e.
  • small inside diameter (11 ⁇ 4 to 31 ⁇ 4 inch, i.e. 32 to 83 mm) tubular member More particularly, it relates to a process involving progressive heating with an internally positioned, electromagnetic induction coil, followed by immediate quenching with a quench ring assembly, to develop a martensitic case on the inner surface of the tube.
  • This method is used to obtain a surface having a hardness of at least 58 HRC and a substantially non-hardened core with a sharp demarcation between the hardened surface and the non-hardened case core.
  • surface hardening a surface of a component it is however advantageous to obtain a hardness profile that does not exhibit a sharp demarcation between the hardened surface and the non-hardened core of the component.
  • a smooth demarcation between the hardened surface and the non-hardened core i.e. a transitional region in which the hardness decreases steadily with depth rather than abruptly mimimizes or eliminates any stresses in the material in that region when the component is in use.
  • Such a steadily decreasing hardness profile may be obtained by carburizing the surface of the component.
  • Carburizing is a heat treatment process in which iron or steel is heated in the presence of another material that liberates carbon as it decomposes. The surface or case will have higher carbon content than the original material. When the iron or steel is cooled rapidly by quenching, the higher carbon content on the surface becomes hard, while the core remains soft (i.e. ductile) and tough.
  • An object of the invention is to provide an improved non-through hardened mechanical component.
  • a mechanical component having a flat or non-flat surface, i.e. an interior or exterior surface, at least one part of which has been surface hardened by induction heating.
  • the surface namely comprises a martensitic microstructure produced by induction hardening using an electromagnetic induction coil followed by quenching using a quenching device.
  • a longitudinal or transverse cross section of the mechanical component through the surface exhibits a hardness suriace at the surface and a hardness H ⁇ re at the non-hardened core of the mechanical component (i.e. in the non-hardened base metal of the mechanical component.
  • the hardness profile of the cross section exhibits a first region whose hardness is substantially equal to the hardness H surfaC e at said surface, a third region whose hardness is substantially equal to the hardness Hcore at the non-hardened core of the mechanical component and a second region between said first and third regions.
  • the hardness profile in the first region has an average hardness Yi
  • the hardness profile in the third region has an average hardness Y 3 . If a line is drawn
  • the hardness of the mechanical component in the second region determined along the line decreases by less than 50 HRC per mm.
  • At least one part of the surface of such a non-through hardened mechanical component will exhibit increased surface hardness, increased wear resistance and/or increased fatigue and tensile strength.
  • the induction hardening heat treatment used to produce such a mechanical component is more energy efficient and cost effective than a carburizing heat treatment and it has a shorter cycling time and provides better distortion control than a carburizing heat treatment.
  • properties, such as the hardness, microstructure and residual stress, of the at least one part of the surface may be tailored as desired for a particular application.
  • k is 1.
  • k is 0.1 , 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.1 , 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, or 1.9.
  • the hardness of the mechanical component in the second region determined along said line decreases by less than 30 HRC, less than 25 HRC, less than 20 HRC, less than 15 HRC or less than 10 HRC per mm.
  • the hardness H surface at the surface is between 55-75 HRC on the Rockwell scale, preferably between 58-63 HRC.
  • the hardness Hco re at the non- hardened core of the mechanical component is between 15-30 HRC.
  • the first region extends from the surface to a depth of up to 6 mm below the surface preferably to a depth of 1-4 mm below the surface, i.e. the material of increased hardness may extend to a depth of about 0.5-6 mm below the surface, preferably 1-2 mm below the surface.
  • the mechanical component may be a steel bar, a cylinder, a rod, a piston, a shaft, or a beam.
  • the mechanical component may for example be used in automotive, wind, marine, metal producing or other machine applications which require high wear resistance and/or increased fatigue and tensile strength.
  • the mechanical component has a contact surface that allows a relative movement between the mechanical component and another component, e.g. a second mechanical component.
  • the contact surface comprises the at least one part that has been hardened.
  • the at least one part essentially corresponds to a contact surface.
  • the mechanical component comprises, or consists of a carbon or alloy steel with an equivalent carbon content of 0.40 to 1.10%, preferably a high carbon chromium steel.
  • the mechanical component comprises/consists of 50CrMo4 steel having a composition in weight % 0.50 C, 0.25 Si, 0.70 Mn, 1.10 Cr, 0.20 P, 100Cr6 steel, or SAE 1070.
  • the present invention also concerns a method for surface hardening at least part of the interior or exterior surface of a mechanical component.
  • the method comprises the steps of heating the at least one part of the surface with an electromagnetic induction coil to the ferrite/austenite transformation temperature or higher by induction heating, maintaining the at least one part of the surface at that temperature in order to allow for sufficient heat transport below the surface resulting in a sufficient austenitization of the at least one part, and quenching the at least one part of the surface in order to obtain a cross section of the mechanical component through the surface which exhibits a hardness H surface at the surface and a hardness ⁇ ⁇ at the non-hardened core of the mechanical component (i.e. in the non-hardened base metal of the mechanical component.
  • the hardness profile of the cross section exhibits a first region whose hardness is substantially equal to the hardness H suriace at said surface, a third region whose hardness is substantially equal to the hardness ⁇ ⁇ at the non- hardened core of the mechanical component and a second region between said first and third regions.
  • the hardness profile in the first region has an average hardness and the hardness profile in the third region has an average hardness Y 3 . If a line is drawn on the
  • the hardness of the mechanical component in the second region determined along the line decreases by less than 50 HRC per mm.
  • conventional induction hardening in which a mechanical component is heated up quickly and/or heat is now allowed to spread through the component, instable in- homogeneous austenite is formed.
  • heat is allowed to spread through the mechanical component for a period of 10 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds or more so that stable, homogeneous austenite is formed.
  • the expression "in order to allow for sufficient heat transport below the surface resulting in a sufficient austenitization of the at least one part,” is therefore intended to mean for a time period sufficient for stable, homogeneous austenite to form in the at least one part of the surface.
  • the hardness of the mechanical component in the second region determined along said line decreases by less than 30 HRC, less than 25 HRC, less than 20 HRC or less than 15 HRC per mm.
  • k is 1. According to another embodiment of the invention k is 0.1 , 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.1 , 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, or 1.9. It should be noted that the expression "an induction coil” as used throughout this document with reference to the mechanical component and method according to the present invention is intended to mean one or more induction coils.
  • a plurality of induction coils operating in the same or a different manner may for example be used to simultaneously or consecutively heat a plurality of parts of an exterior surface and/or an interior surface of a mechanical component, or one or more parts of a plurality of the mechanical components.
  • the induction coil(s) may be arranged to surround one or more parts of a mechanical component that is to be hardened or the entire mechanical component.
  • a quenching device such as a quench spray or ring
  • the mechanical component is removed from the induction coil, and a quenching device, such as a quench spray or ring, is used to immediately quench the at least one part of the surface that has been heat treated.
  • the first region extends from the surface to a depth of up to 6 mm below the surface preferably to a depth of 1-4 mm below the surface.
  • the mechanical component may be a steel bar, a cylinder, a rod, a piston, a shaft, or a beam.
  • Figure 3 shows a cross section of a mechanical component according to an embodiment of the present invention
  • Figures 4 & 5 show hardness profiles of a mechanical component according to an embodiment of the present invention.
  • Figure 6 shows a comparison of hardness profiles obtained using carburization and induction hardening.
  • FIG. 1 schematically shows a thick-walled rotationally symmetrical mechanical component 10 manufactured from steel, namely a cylinder manufactured from a solid steel bar, which is to be used as a shaft, in cross section.
  • the shaft 10 is, for example, 5 made of 50CrMo4 steel and comprises a hole 12 and a uniform circular cross section which extends all the way through the centre of the component in the longitudinal direction thereof.
  • the shaft 10 has a minimum thickness T measured from an interior surface 12a constituting the exterior perimeter of the hole 12 radially outwards to an exterior surface 10a of the shaft 10 (or from 12b to 10b).
  • the minimum thickness T is 7mm, 10 mm, 20 10 mm, 30 mm or more.
  • the hole 12 may alternatively be conical for example and thus have a non-uniform cross sectional size. Alternatively or additionally, the hole 12 may be arranged to have a non-uniform cross sectional shape.
  • An electromagnetic induction coil 14 is used to harden at least one part of the exterior 15 10a, 10b of the shaft 10.
  • a source of high frequency electricity (about 1 kHz to 400 kHz) is used to drive a large alternating current through the induction coil 14.
  • the relationship between operating frequency and current penetration depth and therefore hardness depth is inversely proportional, i.e. the lower the frequency the greater the hardness depth.
  • 25 shaft 10 is heated to the ferrite/austenite transformation temperature or higher by induction heating and preferably maintained at that temperature for 10-40 seconds.
  • the induction coil 14 is then removed and a quenching device 16, such as a quench spray or ring is used to immediately quenching the at least 35 one part of the exterior surface 10a, 10b that has been heat treated.
  • the at least one part of the exterior surface 10a, 10b may for example be quenched to room temperature (20- 25°C) or to 0°C or less.
  • the quenching device 16 is arranged to provide a water-, oil- or polymer-based quench to the heated exterior surface layer 10a, 10b whereupon a martensitic structure which is harder than the base metal of the shaft 10 is formed.
  • the microstructure of the remainder of the shaft 10 remains essentially unaffected by the heat treatment and its physical properties will be those of the bar from which it was machined.
  • a plurality of surfaces of the mechanical component according to the present invention may be surface hardened.
  • at least part of an interior surface 12a, 12b of the mechanical component may also be subjected to the method according to the present invention.
  • the interior surface 12a, 12b may for example be hardened to a depth 1-2mm while the exterior surface 10a, 10b of the mechanical component 10 may be hardened to a depth of 4-6 mm, depending on the application in which the mechanical component 10 is to be used.
  • a 60-200kW power supply a frequency of 20-60 kHz, preferably 10-30 kHz or 15-20 kHz a total heating time of 10-40 seconds and a quenching rate and time of 200l/min and quenching time of 40-70s respectively may be used to obtain a mechanical component according to the present invention.
  • Figure 2 shows the position of the quenching device 16 while quenching is taking place. It should be noted that at least one other part of the outside surface 10a, 10b, 10s of the shaft 10 may alternatively be subjected to another surface hardening heat treatment, such as induction hardening flame hardening or any other conventional heat treatment.
  • another surface hardening heat treatment such as induction hardening flame hardening or any other conventional heat treatment.
  • the shaft 10 in the illustrated embodiment has been shown in a horizontal position with the induction coil 14 and quenching device 16 being inserted horizontally, it should be noted that the shaft 10 may be oriented in any position.
  • An induction coil 14 and quenching device 16 may for be moved vertically into place from the same or different ends of the roller 10.
  • An induction coil 14 may for example be vertically lowered into place and a quenching device may be vertically raised as the induction coil 12 is withdrawn by raising it vertically.
  • Figure 3 shows a longitudinal cross section of the shaft 10 after the heat treatment.
  • Part microstructure produced by induction hardening using an electromagnetic induction coil 14 followed by immediate quenching using a quenching device 16.
  • the method according to the present invention results in the formation of a transition zone visible in both hardness and in microstructure.
  • the heat treated part 18 of the exterior surface material 10a, 10b may namely have a hardness within the range of 55-75 HRC on the Rockwell, preferably 59-63 HRC.
  • the material of increased hardness 18 may for example extend to a depth of up to 6 mm, preferably 1-4 mm below the exterior surface 10a, 10b measured radially downwards from the exterior surface 10a, 10b of the shaft 10 towards the interior surface of the shaft 12a, 12b respectively in the illustrated embodiment.
  • Such a shaft 10 may be used for any application in which a part of the exterior surface 10a, 10b is subjected to increased wear, fatigue or tensile stress.
  • the entire exterior surface 10a, 10b may be subjected to the method according to the present invention, depending on the application for which the shaft 10 is to be used.
  • the interior surface 12a, 12b of the shaft 10 may for example comprise a thread (not shown) arranged to mate with a corresponding thread of another component.
  • Figure 4 shows a hardness profile 22 of a longitudinal cross section of a mechanical component according to an embodiment of the invention measured radially through a surface hardened region 18 in the direction of arrow 20 shown in figure 3.
  • the hardness profile 22 exhibits a first region 24 whose hardness is substantially equal to the hardness Hsurface at the outer surface 10a, 10b of the mechanical component 10, between 55-75 HRC, preferably between 58-63 HRC for example.
  • the hardness profile 22 also comprises a third region 26 whose hardness is substantially equal to the hardness H core at the non-hardened core 10c of the mechanical component 10, between 15-30 HRC for example.
  • the hardness profile 22 also comprises a second region 25 between the first region 24 and the third region 26 in which the hardness profile exhibits a smooth transition between the hardness of the first region 24 and the third region 26, i.e. the hardness profile exhibits a transitional region in which hardness decreases steadily with depth below the surface rather than abruptly.
  • the hardness profile in the first region 24 has an average hardness and the hardness profile in the third region 26 has an average hardness Y 3 , and if a line is drawn on the hardness profile in the second region 25 Y + Y - Y, Y + Y, - Y,
  • the hardness of the mechanical component in the second region determined along the line decreases by less than 50 HRC per mm.
  • the interior surface 12a, 12b of the shaft 10 is subjected to a method according to the present invention it will also have a similarly shaped hardness profile although its hardness values may be selected to be different from the hardness values of the exterior surface 10a, 10b of the shaft 10.
  • the depth of the first region 24 and second region 25 may be chosen depending on the application in which the mechanical component 10 is to be used.
  • the dashed line in figure 4 shows a hardness profile 30 having a sharp demarcation between the hardness H surfa ce at the outer surface 10a, 10b of the mechanical component 10 and the hardness H core at the non-hardened core 10c of the mechanical component 10 in which the hardness decreases by more than 50 HRC per mm.
  • Figure 5 shows a hardness profile 22 obtained using the method according to the present invention and determined from measured hardness values (measured using Vicker's Hardness Test or any other suitable method). The values may be extrapolated to a depth of 0 mm in order to obtain the hardness H surf ace at the outer surface 10a, 10b of the mechanical component 10.
  • the hardness of the mechanical component 10 at a depth of 6-8 mm below the surface of the mechanical component 10 may be considered to be the hardness ⁇ at the non-hardened core 10c of the mechanical component 10.
  • Figure 6 shows a comparison between hardness profiles obtained using carburization 24, conventional induction hardening 26 and the method according to the present invention 22. It can be seen that the hardness profile resulting from conventional induction hardening 26 decreases abruptly in the transitional region corresponding to the second region 25, as shown in figure 4. It can also be seen that the hardness profile obtained using the method according to the present invention 22 decreases much more steadily with depth. Further modifications of the invention within the scope of the claims would be apparent to a skilled person. For example, rather than moving an induction coil and/or quenching device into position relative to a stationary mechanical component, a mechanical component may be moved into position relative to a stationary induction coil and/or quenching device.

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Heat Treatment Of Articles (AREA)
PCT/SE2011/000094 2010-07-02 2011-05-27 Mechanical component and method for surface hardening WO2012002863A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2013518314A JP2013532233A (ja) 2010-07-02 2011-05-27 機械構成要素、および表面硬化方法
US13/808,056 US20130216856A1 (en) 2010-07-02 2011-05-27 Mechanical component and method of surface hardening
CN2011800391476A CN103080343A (zh) 2010-07-02 2011-05-27 机械部件和用于表面硬化的方法
EP11801220.2A EP2598662A1 (en) 2010-07-02 2011-05-27 Mechanical component and method for surface hardening

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1000719-3 2010-07-02
SE1000719 2010-07-02

Publications (1)

Publication Number Publication Date
WO2012002863A1 true WO2012002863A1 (en) 2012-01-05

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PCT/SE2011/000094 WO2012002863A1 (en) 2010-07-02 2011-05-27 Mechanical component and method for surface hardening

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US (1) US20130216856A1 (zh)
EP (1) EP2598662A1 (zh)
JP (1) JP2013532233A (zh)
CN (1) CN103080343A (zh)
WO (1) WO2012002863A1 (zh)

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US11141412B2 (en) 2014-06-30 2021-10-12 Prilenia Neurotherapeutics Ltd. Analogs of pridopidine, their preparation and use
US11207310B2 (en) 2016-08-24 2021-12-28 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating functional decline
US11207308B2 (en) 2012-04-04 2021-12-28 Prilenia Neurotherapeutics Ltd. Pharmaceutical compositions for combination therapy
US11234973B2 (en) 2017-01-20 2022-02-01 Prilenia Neurotherapeutics Ltd. Use of pridopidine for the treatment of fragile X syndrome
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US11471449B2 (en) 2015-02-25 2022-10-18 Prilenia Neurotherapeutics Ltd. Use of pridopidine to improve cognitive function and for treating Alzheimer's disease
US12036213B2 (en) 2017-09-08 2024-07-16 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
US12102627B2 (en) 2016-09-16 2024-10-01 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating rett syndrome

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CN112149333B (zh) * 2020-09-28 2023-10-31 上海交通大学 轴承滚道激光-感应复合淬火工艺参数优化方法

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