WO2011145909A2 - 판두라틴 유도체 또는 보에센베르기아 판두라타 추출물의 근육 증가 촉진, 항-피로 및 운동수행능력 향상에 관한 새로운 용도 - Google Patents
판두라틴 유도체 또는 보에센베르기아 판두라타 추출물의 근육 증가 촉진, 항-피로 및 운동수행능력 향상에 관한 새로운 용도 Download PDFInfo
- Publication number
- WO2011145909A2 WO2011145909A2 PCT/KR2011/003735 KR2011003735W WO2011145909A2 WO 2011145909 A2 WO2011145909 A2 WO 2011145909A2 KR 2011003735 W KR2011003735 W KR 2011003735W WO 2011145909 A2 WO2011145909 A2 WO 2011145909A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- panduratin
- present
- fatigue
- extract
- boesenbergia pandurata
- Prior art date
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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Definitions
- the present invention relates to a novel use for promoting muscle growth, anti-fatigue and exercise performance of panduratin derivatives or boesenbergia pandurata extract, and more specifically, panduratin derivatives or salts thereof.
- Boesenbergia pandurata extract as an active ingredient, promoting muscle performance and promoting fatigue by promoting muscle recovery and fatigue recovery, muscle growth and anti-fatigue composition, panduratin derivatives or salts thereof or
- the present invention relates to a method for improving exercise performance, promoting muscle growth, and anti-fatigue method of administering Boesenbergia pandurata extract to an individual in need thereof.
- Skeletal muscle fibers are generally classified into crab type (Oxidative / slow) and glycolyt ic / fast (fibrous type) fibers. to fatigue).
- Type 1 fibers are rich in mitochondria and mainly use oxidative metabolism for energy generation, so they can provide stable ATP for a long time and can withstand fatigue.
- skeletal muscles rich in type 1 fibers do not cause muscle wasting (Muscle Nerve 2005, 31, P 339-348).
- Type 2 fibers are low in mitochondria and oxidase, and depend on glycolic metabolism as their primary energy source, making them easily fatigued.
- Activated Receptor ⁇ is a major transcription factor that is primarily present in skeletal muscles, especially type 1 fibers (10 times PPARa, 50 times PPARY) and activates enzymes related to beta oxidation of long-chain fatty acids to burn fat in fat cells. It is a regulator (Cell 2003, 113, pl59-170), a transcription factor of system 1 that promotes system type 1 fiber formation. These PPARSs are known to be involved in complex pathways that regulate mitochondrial biosynthesis when activated, enhance motor performance and increase resistance to obesity (PL0S Biology 2004, 2, pl532-1539). Therefore, the U-shaped fibers made adaptively through exercise are known to be fatigue-resistant.
- the present inventors conducted a study to increase the activity of PPARS in muscle and to search for natural products with excellent safety, and extracts of Boesenbergia pandurata, which is a Zingiberaceae family plant, and The panduratin derivative isolated from the increase the expression of PPARS protein in muscle, and confirmed that to enhance the performance of exercise by promoting muscle reinforcement and fatigue recovery to complete the present invention.
- An object of the present invention is to provide a composition for improving exercise performance, comprising a panduratin derivative or a salt thereof as an active ingredient.
- Still another object of the present invention is to provide a composition for promoting muscle growth, comprising the extract of Boesenbergia pandurata as an active ingredient.
- Still another object of the present invention is to provide an anti-fatigue composition
- an anti-fatigue composition comprising a panduratin derivative or a salt thereof as an active ingredient.
- Another object of the present invention is to provide an anti-fatigue composition
- an anti-fatigue composition comprising a boesenbergia pandurata extract as a good ingredient.
- Still another object of the present invention is to provide a method for improving exercise performance, which comprises administering an effective amount of a panduratin derivative or a salt thereof to an individual in need thereof.
- Still another object of the present invention is to provide a use of a panduratin derivative or a salt thereof for the preparation of an agent for improving exercise performance.
- Still another object of the present invention is to provide a method for improving exercise performance, comprising administering an effective amount of Boesenbergia pandurata extract to an individual in need thereof.
- Another object of the present invention is to provide a use of the boesen bergia pandurata extract for the preparation of a preparation for improving athletic performance.
- Another object of the present invention is to provide a use of a panduratin derivative or a salt thereof for the preparation of a preparation for promoting muscle growth.
- Still another object of the present invention is to provide a method for promoting muscle growth, comprising administering an effective dose of Boesenbergia pandurata extract to an individual in need thereof.
- Still another object of the present invention is to provide a use of Boesenberg kia pandurata extract for the preparation of a preparation for promoting muscle growth.
- It is another object of the present invention to provide an anti-fatigue method comprising administering an effective dose of Boesenbergia pandurata extract to an individual in need thereof.
- Another object of the present invention is to provide the use of Boesenbergia pandurata extract for the preparation of an anti-fatigue formulation.
- the present invention provides a composition for improving exercise performance including a panduratin derivative or a salt thereof as an active ingredient.
- the present invention provides a composition for improving exercise performance comprising Boesenbergia pandurata extract as an active ingredient.
- the present invention provides a composition for promoting muscle growth comprising a panduratin derivative or a salt thereof as an active ingredient.
- the present invention provides a composition for promoting muscle growth comprising Boessenbergia pandu rata extract as an active ingredient.
- the present invention provides an anti-fatigue composition
- a panduratin derivative or a salt thereof as an active ingredient.
- the present invention provides an anti-fatigue composition
- a boesenbergia pandurata extract as an active ingredient.
- the present invention provides a method for improving athletic performance, comprising administering an effective amount of a panduratin derivative or a salt thereof to an individual in need thereof.
- the present invention provides a use of a panduratin derivative or a salt thereof for the preparation of an agent for improving athletic performance.
- the present invention provides a method for improving exercise performance, comprising administering an effective dose of Boesenbergia pandu rata extract to an individual in need thereof.
- the present invention provides the use of Boesenbergia pandurata extract for the preparation of a preparation for improving exercise performance.
- the present invention provides panduratin derivatives or It provides a method for promoting muscle growth characterized in that the salt thereof is administered to an individual in need thereof in an effective amount.
- the present invention provides the use of a panduratin derivative or a salt thereof for the preparation of a formulation for promoting muscle growth.
- the present invention provides a method for promoting muscle growth, comprising administering an effective dose of Boesenbergia pandu rata extract to a subject in need thereof.
- the present invention provides the use of Boesenbergia pandurata extract for the preparation of a formulation for promoting muscle growth.
- the present invention provides an anti-fatigue method characterized in that an effective amount of a panduratin derivative or a salt thereof is administered to an individual in need thereof.
- the present invention provides the use of panduratin derivatives or salts thereof for the preparation of anti-fatigue preparations.
- the present invention provides an anti-fatigue method comprising administering an effective dose of Boesenbergia pandu rata extract to a subject in need thereof.
- the present invention provides the use of Boesenbergia pandurata extract for the preparation of an anti-fatigue formulation.
- composition of the present invention includes a panduratin derivative or a salt thereof as an active ingredient, which increases the muscle mass by increasing PPARS expression of muscle cells and improves exercise performance by restoring fatigue.
- Panduratin derivatives include panduratin A) represented by Formula 1, 4—hydroxypanduratin A represented by Formula 2, and isopanduratin represented by Formula 3. AGsopanduratin A).
- Pandurarin A is (2,6-dihydroxy-4-methoxyphenyl) [3—methyl-2- (3-methylbut-2-enyl) -5—phenylcyclonux-3-enyl] methanone And the molecular formula is C 26 H 30 0 4 .
- 4-hydroxythoxypanduratin A is (2,4,6—trihydroxypheny [3-methyl-2- (3-methylbut-2-enyl) -6-phenylcyclonux-3-enyl] meta Rice, and the molecular formula is C 25 H 28 0 4.
- Isopanduratin A is (2-methoxy-4, 6-dihydrospecificphenyl H3-methyl -2— (3-methylbut-2-enyl) -6-phenylcyclonux-3-enyl] methionone
- the molecular formula is C 26 H 30 0 4 .
- the panduratin derivative is generally a commercially available material, or may be prepared using a known synthetic method, and is separated and purified from oil obtained by compressing a boesenbergia pandurata extract or a boesenbergia pandurata plant. Can be obtained.
- panduratin derivatives included in the composition of the present invention are dried and extracted Boesenbergia tubedurata rhizome (rhizome) using purified water, ethane and subcritical water or supercritical water carbon dioxide suitable for food processing. It can be obtained or it can be obtained by separating and purifying from the oil obtained by directly compressing the Boesenbergia pandurata plant.
- panduratin derivatives from extracts of Boesenbergia pandurata is characterized by column chromatography and high performance liquid chromatography (HPLC) layered on various synthetic resins such as silica gel and activated alumina.
- HPLC high performance liquid chromatography
- the black and the like can be used alone, but the extraction and separation and purification of panduratin derivatives are not necessarily limited to the above methods.
- composition of the present invention is characterized by having an effect of improving exercise performance.
- exercise performance is closely related to athletes' performance and record improvement and can be improved by improving cardiopulmonary function, promoting energy metabolism, restoring fatigue, and increasing muscle strength.
- the performance of the exercise can be improved by a method of rapidly recovering fatigue and increasing endurance during exercise.
- the composition of the present invention provides a function of increasing the expression of PPAR5 contained in a large amount of type 1 fibers in skeletal muscle fibers.
- PPARS is a factor that promotes the transcription of type 1 fibers, and because lactic acid is produced as a source of energy in muscles with many types 1 fibers. This does not accumulate muscle fatigue, and consequently improves exercise performance.
- Boesenbergia pandurata is a type of plant of the Zingiberaceae family, also called Kaempfer ia pandurata.
- Boesenbergia pandurata extract is composed of inocembr in chalcone, cardamonin, pinocembr in, pinostribin, 4-hydroxyfanduratin A 4-hydroxypadurat ⁇ ), panduratin A and isopanduratin A. These ingredients have anti-cancer effects (Trakoontivakorn, G., et al., J. Arig.
- panduratin A was extracted and separated from Boesenbergia pandurata extract. (See Examples 1 to 2)
- Panduratin derivatives of the invention can be used on their own or in the form of salts or pharmaceutically acceptable salts.
- 1 pharmaceutically acceptable means physiologically acceptable and does not cause an allergic reaction or similar reaction when administered to humans, and the salt is a pharmaceutically acceptable free acid.
- the free acid may be an organic acid or an inorganic acid.
- the organic acid may be, but is not limited to, citric acid, Acetic acid, lactic acid, tartaric acid, maleic acid, fumaric acid, formic acid, propionic acid, oxalic acid, trifluoroacetic acid, benzoic acid, gluconic acid, metasulfonic acid, glycolic acid, succinic acid, 4-roluenesulfonic acid, glutamic acid and aspartic acid.
- the inorganic acid includes, but is not limited to, hydrochloric acid, bromic acid, sulfuric acid and phosphoric acid.
- the composition of the present invention has a toxing effect that has a muscle growth promoting effect.
- Muscle increase is to improve muscle performance, especially among the body components, can increase muscle mass through physical luck and endurance, and increase the muscle mass by administering a substance having an effect of increasing muscles in the body Muscles are not limited to their kind, but the compositions of the present invention have the effect of promoting an increase in crab type skeletal muscle fibers, in particular.
- the composition of the present invention is characterized by having an anti-fatigue effect.
- “Fatigue” is divided into mental fatigue and physical fatigue.
- “fatigue” refers to the physical fatigue accumulated in the muscles after the exercise, which means the muscle lysogen concentration, lactate dehydrogenase activity and citric acid synthesis It is caused by enzyme activity.
- the composition of the present invention promotes the transcription of type 1 skeletal muscle fibers that can be synthesized oxidatively by oxidative metabolism. Increasing the expression of PPAR5 has the effect of less fatigue in the muscles.
- the composition of the present invention may be provided in the form of a pharmaceutical composition or a food composition.
- the pharmaceutical composition of the present invention may include a pharmaceutically effective amount of panduratin derivative or bo essenbergia pandurata extract alone or one or more pharmaceutically acceptable carriers.
- the pharmaceutical composition of the present invention may contain 0.01 to 99.99% of panduratin derivative or boesenbergia pandurata extract, and the remaining amount may be occupied by a pharmaceutically acceptable carrier.
- the pharmaceutically effective amount of the panduratin derivative or boesenbergia panduratata extract according to the present invention is 0.001 to 300 mg / day / kg body weight, preferably 0.01 to 200 mg / day / kg body weight.
- the pharmaceutically effective amount may be appropriately changed depending on various factors such as the disease and its severity, the patient's age, weight, health condition, sex, route of administration and duration of treatment.
- pharmaceutically acceptable means physiologically acceptable and administered to humans. When used, it refers to a non-toxic composition that does not inhibit the action of the active ingredient and does not usually cause allergic reactions such as gastrointestinal disorders, dizziness or similar reactions.
- Such carriers include all kinds of solvents, dispersion media, oil-in-water or water-in-oil emulsions, aqueous compositions, liposomes, microbeads and microsomes.
- the pharmaceutical composition according to the present invention can be formulated with a suitable carrier depending on the route of administration.
- the route of administration of the pharmaceutical composition according to the present invention is not limited thereto, but may be administered orally or parenterally.
- Parenteral routes of administration include, for example, transdermal, nasal, abdominal, muscle, subcutaneous or intravenous routes.
- the pharmaceutical composition of the present invention may be prepared in powder, granule, tablet, pill, dragee, capsule, liquid, gel according to a method known in the art together with a suitable oral carrier.
- a suitable oral carrier Sugar, corn, syrup, suspension, wafer, etc.
- suitable carriers include sugars and corn, including lactose, dextrose, sucrose solbi, mannitol, xylly erythritol, maltitol, and the like.
- Starch including starch, wheat starch, rice starch and potato starch, cellulose, gelatin, cellulose, methyl cellulose, sodium carboxymethyl cellulose, hydroxypropylmethyl-cellulose, etc.
- Fillers such as polyvinylpyridone and the like.
- crosslinked polyvinylpyridone, agar, alginic acid or sodium alginate may be added as a disintegrant.
- the pharmaceutical composition may further include an anticoagulant, a lubricant, a humectant flavor, an emulsifier and a preservative.
- compositions of the present invention may be formulated according to methods known in the art in the form of injections, transdermal and nasal injections, together with suitable parenteral carriers.
- suitable parenteral carriers include, but are not limited to, solvents including water, ethanol, polyols (e.g. glycerin, propylene glycol and liquid polyethylene glycols), combinations thereof and / or vegetable oils, or It may be a dispersion medium.
- suitable carriers include Hanks solution, Ringer's solution, phosphate buffered saline (PBS) containing triethanol amine or sterile water for injection, 10% ethanol, 40% propylene glycol and 5% dextrose. Etc. can be used.
- PBS phosphate buffered saline
- the injection may in most cases further comprise an isotonic agent such as sugar or sodium chloride.
- transdermal administration means that the pharmaceutical composition is administered to the skin topically so that an effective amount of the active ingredient contained in the pharmaceutical composition is delivered into the skin.
- transdermal administration means that the pharmaceutical composition is administered to the skin topically so that an effective amount of the active ingredient contained in the pharmaceutical composition is delivered into the skin.
- the compounds used according to the invention may be prepared using suitable propellants such as dichlorofluoromethane, trichloropolomethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. It can be delivered conveniently in the form of aerosol spray from pressurized pack or nebulizer. In the case of a pressurized aerosol, the dosage unit can be determined by providing a valve to deliver a metered amount.
- gelatin capsules and cartridges for use in inhalers or blowers can be formulated to contain a compound and a powder mixture of a suitable powder base such as lactose or starch.
- compositions according to the invention may contain one or more buffers (e.g. saline or PBS), carbohydrates (e.g. glucose, mannose, sucrose or dextran), antioxidants Agents, bacteriostatic agents, chelating agents (eg EDTA or glutathione), adjuvants (eg aluminum hydroxide), suspending agents, thickening agents and / or preservatives.
- buffers e.g. saline or PBS
- carbohydrates e.g. glucose, mannose, sucrose or dextran
- antioxidants Agents e.g. glucose, mannose, sucrose or dextran
- bacteriostatic agents e.g. EDTA or glutathione
- adjuvants eg aluminum hydroxide
- panduratin derivative or Boesenbergia pandurata extract according to the present invention may be provided in the form of a food composition that promotes muscle strengthening and fatigue recovery to promote exercise performance.
- the food composition of the present invention includes all forms such as functional food, nutritional supplement, health food, food additives and feed, and can be used for animals including humans or livestock. It is for eating. Food compositions of this type can be prepared in various forms according to conventional methods known in the art.
- the panduratin derivative or Boesenbergia pandurata extract of the present invention may be prepared in the form of tea, juice and drink for drinking. B, granulated, encapsulated and powdered for ingestion. In addition, it can be prepared in the form of a composition by mixing with panduratin or boesenbergia pandurata extract of the present invention and known active ingredients known to have the effect of promoting muscle enhancement and fatigue recovery to promote athletic performance Can be.
- functional foods include beverages (including alcoholic beverages), fruits and processed foods (eg canned fruit, canned food, jams, marmalade, etc.), fish, meat and processed foods (eg ham, Sausages, corned beef, etc., breads and noodles (e.g. udon noodles, soba noodles, ramen noodles, spaghetti, macaroni, etc.), fruit juices, various drinks, cookies, candy, dairy products (e.g. butter, cheese), edible vegetable oils , Margarine, vegetable protein, retort food, frozen food, various seasonings (eg, miso, soy sauce, etc.) and the like can be prepared by adding the panduratin derivative or boesenbergia pandurata extract of the present invention.
- fruits and processed foods eg canned fruit, canned food, jams, marmalade, etc.
- fish e.g. udon noodles, soba noodles, ramen noodles, spaghetti, macaroni, etc.
- breads and noodles e.g. udon noodles
- panduratin derivative or boesenbergia pandurata extract of the present invention in the form of a food additive, it may be prepared in powder or concentrate form.
- panduratin derivative or boesenbergia pandurata extract of the present invention in the food composition of the present invention is about 0.01 to about the total amount of food.
- the present invention provides a method for improving exercise performance, characterized in that the effective administration of a panduratin derivative or a salt thereof to an individual in need thereof.
- the present invention provides the use of a panduratin derivative or a salt thereof for the preparation of a preparation for improving athletic performance.
- the present invention provides a method for improving exercise performance, characterized in that the administration of Boesenbergia pandurata extract to an individual in need thereof in an effective amount.
- the present invention provides a use of the Boesenbergia panduratata extract for the preparation of a preparation for improving exercise performance.
- the present invention provides a method for promoting muscle growth, characterized in that the administration of a panduratin derivative or a salt thereof in an effective amount to a subject in need thereof.
- the present invention provides the use of a panduratin derivative or salt thereof for the preparation of a formulation for promoting muscle growth.
- the present invention provides a method for promoting muscle growth, characterized in that the Boesenbergia pandurata extract is administered to an individual in need thereof in an effective amount.
- the present invention provides the use of Boesenbergia pandurata extract for the preparation of a formulation for promoting muscle growth.
- the present invention provides an anti-fatigue method characterized in that an effective amount of a panduratin derivative or a salt thereof is administered to an individual in need thereof.
- the present invention provides the use of panduratin derivatives or salts thereof for the preparation of anti-fatigue formulations.
- the present invention provides an anti-fatigue method comprising administering an effective dose of Boesenbergia pandurata extract to a subject in need thereof.
- the present invention provides the use of Boesenbergia pandurata extract for the preparation of an anti-fatigue formulation.
- the effective amount refers to an effective effect in a subject to which the panduratin derivative or salt thereof or Boesenbergia pandurata extract of the present invention is administered, that is, to improve exercise performance or to promote muscle growth or to prevent it.
- the subject may be a subject that needs to improve athletic performance, needs muscle gain, or needs fatigue suppression.
- the present invention provides a composition (or method or use) for promoting muscle growth anti-fatigue and exercise performance, comprising a panduratin derivative or a salt thereof or a boesenbergia pandurata extract.
- the panduratin derivative or boesenbergia pandurata extract of the present invention can be safely used without side effects, and has an excellent effect on improving exercise performance, such as increasing muscle mass, fatigue recovery and increased mobility by increasing the expression of PPAR5 in the muscle.
- Figure 1 is a high fat diet control, Boesenbergia pandurata extract
- Figure 2 is a high fat diet control, Boesenbergia pandurata extract
- KPE 100 The results of the measurement of the increase in muscle mass of 100 mg / kg / day (KPE 100), Boesenbergia pandurata extract 200 mg / kg / day (KPE 200), and panduratin A-administered group (PAN 50).
- Figure 3 is a high fat diet control, Boesenbergia pandurata extract
- KPE 100 100mg / kg / day
- PE 200 Boesenbergia pandurata extract 200mg / kg / day
- PAN 50 Panduratin A administration group
- the dried Boesenbergia pandurata extract was pulverized with a mixer, and 100 g of the pulverized Boesenbergia pandurata sample was added to 500 mL of ethane and extracted with stirring at 50 ° C for 30 minutes.
- the extracted sample was filtered using Whatman No. 2 filter paper, the filtered extract was concentrated with a vacuum rotary concentrator to remove the solvent component, and then lyophilized to remove the physical component, thereby obtaining Boesenbergia pandurata extract.
- the concentrated components were loaded on a column packed to 615 cm, and nucleic acids, chloroform and ethyl acetate were separated using a mixed solvent system at a ratio of 15: 5: 1.5 (v / v / v). Each fraction was concentrated to dryness by dividing into six fractions according to the aliquots. All. Thin fraction chromatography (TLC, silica gel 60F254, Merck) using three fractions (fraction 3) of six fractions (fraction 3) using nucleic acid, ethyl acetate, and methanol as a developing solvent of 18: 2: 1 (v / v / v), respectively. The mixture was divided into three fractions according to the order of fractionation and concentrated to dryness.
- 22> In order to structure the single active material separated in Example ⁇ 2-1>, ⁇ -NMR spectrum and 13 C-NMR spectrum were measured at 500 MHz and 125 MHz (solvent: CDC13), respectively. In order to measure the correlation between the obtained 13 ONMR spectrum and the- ⁇ spectrum, the COSY spectrum and — 13 C HSQC spectrum were measured, and each carbon signal was measured with the wavelength emitted through carbon resonance. The result was measured separately.
- EI / MS was also measured for mass spectrometry of the isolated single material.
- This compound ⁇ is found to have a molecular weight of 406 with [M + H +] observed at m / z 407 in EI / MS, and the molecular formula was C 26 H 30 0 4 .
- Example ⁇ 124> Results of more than- ⁇ , 13 C- ⁇ , HH COZY, H- L3 C HSQC and EI / MS and previous published reports (Woo, WS et al., Phytochemi stry, 26: 15421543, 1987) was identified by comparative analysis, the single substance isolated in Example ⁇ 2-1> was (2,6-dihydroxy _4-methoxyphenyl) [3-methyl-2- (3-methylbut — 2—enyl) -5-phenylcyclonux-3janenyl] methanone, which was identified as panduratin A compound represented by the following formula (1). ⁇ 125> [Formula 1]
- panduratin A and boesenbergia pandurata extract were suspended in 0.25% carboxymethylcellulose, and panduratin A was 50 mg / kg (PAN 50) and boesen bergia pandurata extract.
- Two doses of 100 mg / kg body weight (KPE 100) and 200 mg / kg body weight (KPE 200) were administered once a day for 8 weeks.
- the group fed high fat diet to the same amount of 0.25% carboxymethylcellose ingested by the experimental group was used.
- the abdomen was fasted for at least 12 hours, and then the abdomen was cut, and muscle tissue was extracted and stored at -70 ° C until the experiment.
- the muscles of 100 mg isolated from each rat of each group were homogenized using lysis beffer and then detected by Western blot experiment using PPAR- ⁇ antibody.
- the expression level of PPAR5 was increased in the group administered with panduratin A and Boesenbergia pandurata extract compared to the control. Since PPAR5 acts as a transcription factor of type 1 skeletal muscle fibers, it can be predicted that the amount of type 1 skeletal muscle fibers will increase as the expression level of PPARS increases. In addition, since the expression of PPARS was higher in the KPE 200-administered group than in the KPE 100-administered group, it can be seen that the mechanism of regulating PPAR5 expression of Boesenbergia pandurata extract is concentration dependent.
- panduratin A and boesenbergia pandurata extract were suspended in 0.25% carboxymethyl cellulose, and panduratin A was 50 mg / kg (PAN 50) and boesen bergia pandurata.
- the extract was administered at a constant time for 8 weeks at a concentration of two concentrations of 100nig / kg body weight (KPE 100), 200mg / kg (PE 200) body weight once a day.
- the group fed high fat diet to 0.25% carboxymethylcellose in the same amount ingested by the experimental group was used.
- the total volume and tissue volume of the rats were measured using micro-computed tomography (CT).
- Panduratin A and Boesenbergia pandurata extracts were suspended in 0.25% carboxymethylcellulose, and Panduratin A was 50 mg / kg body weight (PAN 50) and Boesen Bergia pandurata extract Two concentrations of 100 mg / kg body weight (KPE 100) and 200 mg / kg body weight (KPE 200) were administered once a day for 8 weeks.
- the group fed high fat diet to 0.25% carboxymethylcellose of the same amount ingested by the experimental group was used.
- the exercise ability was measured at llm / min rate in a 10% kiln using an Exer-3R treadmill.
- the present invention provides a composition for promoting muscle growth, anti-fatigue and improving exercise performance, including a panduratin derivative or a salt thereof or Boersenbergia pandurata extract.
- the panduratin derivative or boesenbergia panduratata extract of the present invention can be safely used without side effects, and has an excellent effect on the improvement of exercise performance, such as muscle mass increase, fatigue recovery and increased mobility by increasing the expression of PPARS in the muscle. .
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Abstract
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JP2013511120A JP5905874B2 (ja) | 2010-05-20 | 2011-05-20 | パンドラチン誘導体又はボエセンベルギアパンドラター抽出物の筋肉増加促進、抗疲労及び運動遂行能力向上に関する新たな用途 |
CN201180029079.5A CN103037854B (zh) | 2010-05-20 | 2011-05-20 | 潘多汀派生物或提琴形凹唇姜萃取物的促进增加肌肉、抗疲劳及提高运动执行能力相关新用途 |
EP11783791.4A EP2572710B1 (en) | 2010-05-20 | 2011-05-20 | Novel use of panduratin derivatives or an extract of boesenbergia pandurata for promoting muscle mass growth, fighting fatigue, and enhancing exercise performance capability |
US13/682,216 US9198880B2 (en) | 2010-05-20 | 2012-11-20 | Use of panduratin derivatives or an extract of Boesenbergia pandurata for promoting muscle mass growth, fighting fatigue, and enhancing exercise performance capability |
US14/846,204 US9452193B2 (en) | 2010-05-20 | 2015-09-04 | Use of panduratin derivatives or an extract of Boesenbergia pandurata for enhancing muscle mass growth, fighting fatigue, and enhancing exercise performance |
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KR101528023B1 (ko) * | 2012-05-16 | 2015-06-15 | 연세대학교 산학협력단 | 캠페리아 파비플로라 추출물 또는 플라본계 화합물을 함유하는 근육 질환 예방 및 치료용 또는 근 기능 개선용 조성물 |
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KR101776001B1 (ko) * | 2016-03-04 | 2017-09-07 | (주)뉴트리 | 판두라틴 또는 핑거루트(보에센베르기아 판두라타) 추출물을 포함하는 골 손실 질환 치료, 예방 또는 개선용 조성물 |
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WO2008023966A1 (en) * | 2006-08-25 | 2008-02-28 | Industry-Academic Cooperation Foundation, Yonsei University | Novel use of panduratin a or derivatives thereof |
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Cited By (2)
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CN104349786A (zh) * | 2012-06-08 | 2015-02-11 | 花王株式会社 | 骨骼肌慢肌化剂 |
CN104349786B (zh) * | 2012-06-08 | 2021-06-15 | 花王株式会社 | 骨骼肌慢肌化剂 |
Also Published As
Publication number | Publication date |
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EP2572710A2 (en) | 2013-03-27 |
JP5905874B2 (ja) | 2016-04-20 |
US20150374777A1 (en) | 2015-12-31 |
US20130344182A1 (en) | 2013-12-26 |
CN103037854B (zh) | 2015-02-04 |
EP2572710B1 (en) | 2018-04-11 |
US9452193B2 (en) | 2016-09-27 |
CN103037854A (zh) | 2013-04-10 |
WO2011145909A3 (ko) | 2012-03-29 |
EP2572710A4 (en) | 2013-11-27 |
JP2013532133A (ja) | 2013-08-15 |
KR20110127879A (ko) | 2011-11-28 |
US9198880B2 (en) | 2015-12-01 |
KR101698201B1 (ko) | 2017-01-19 |
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