WO2011098962A3 - Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent - Google Patents

Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent Download PDF

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Publication number
WO2011098962A3
WO2011098962A3 PCT/IB2011/050554 IB2011050554W WO2011098962A3 WO 2011098962 A3 WO2011098962 A3 WO 2011098962A3 IB 2011050554 W IB2011050554 W IB 2011050554W WO 2011098962 A3 WO2011098962 A3 WO 2011098962A3
Authority
WO
WIPO (PCT)
Prior art keywords
functionalised
hydrophobic groups
anionic polysaccharides
spacer
groups supported
Prior art date
Application number
PCT/IB2011/050554
Other languages
English (en)
Other versions
WO2011098962A2 (fr
Inventor
Richard Charvet
Rémi SOULA
Olivier Soula
Original Assignee
Adocia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1000537A external-priority patent/FR2956116A1/fr
Priority claimed from FR1001474A external-priority patent/FR2958647B1/fr
Application filed by Adocia filed Critical Adocia
Priority to JP2012552512A priority Critical patent/JP5950458B2/ja
Priority to CN201180011939.2A priority patent/CN102834117B/zh
Priority to BR112012019580-8A priority patent/BR112012019580A2/pt
Priority to RU2012138454/05A priority patent/RU2575460C2/ru
Priority to EP11710319A priority patent/EP2533812A2/fr
Publication of WO2011098962A2 publication Critical patent/WO2011098962A2/fr
Publication of WO2011098962A3 publication Critical patent/WO2011098962A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
    • C08B11/12—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals, e.g. carboxymethylcellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/14—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals with nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0018—Pullulan, i.e. (alpha-1,4)(alpha-1,6)-D-glucan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates

Abstract

La présente invention concerne de nouveaux dérivés de polysaccharides anioniques en partie fonctionnalisés par au moins deux groupements hydrophobes vicinaux, lesdits groupements hydrophobes identiques ou différents étant portés par un radical ou spacer au moins trivalent. Elle concerne également leurs méthodes de synthèse. L'invention concerne également l'utilisation des polysaccharides fonctionnalisés selon l'invention pour la préparation de compositions pharmaceutiques comprenant l'un des polysaccharides selon l'invention et au moins un principe actif.
PCT/IB2011/050554 2010-02-09 2011-02-09 Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent WO2011098962A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2012552512A JP5950458B2 (ja) 2010-02-09 2011-02-09 少なくとも３価のスペーサーにより保有される少なくとも２つの疎水性基により官能化されたアニオン性多糖類
CN201180011939.2A CN102834117B (zh) 2010-02-09 2011-02-09 通过至少两个由至少三价的间隔物所携带的疏水基团进行官能化的阴离子多糖
BR112012019580-8A BR112012019580A2 (pt) 2010-02-09 2011-02-09 "polissacarídeos antônicos funcionalizados por pelo menos dois grupos hidrofóbicos carreados por pelo menos um espaçador trivalente
RU2012138454/05A RU2575460C2 (ru) 2010-02-09 2011-02-09 Анионные полисахариды, функционализированные по меньшей мере двумя гидрофобными группами, связанными с по меньшей мере трехвалентной промежуточной группировкой
EP11710319A EP2533812A2 (fr) 2010-02-09 2011-02-09 Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FR1000537A FR2956116A1 (fr) 2010-02-09 2010-02-09 Complexes polysaccharide/bmp-7 solubles a ph physiologique
FR1000537 2010-02-09
US28284610P 2010-04-08 2010-04-08
US61/282,846 2010-04-08
FR1001474 2010-04-08
FR1001474A FR2958647B1 (fr) 2010-04-08 2010-04-08 Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent.
IBPCT/IB2010/002970 2010-11-19
PCT/IB2010/002970 WO2011061615A1 (fr) 2009-11-19 2010-11-19 Complexes polysaccharide / bmp solubles a ph physiologique

Publications (2)

Publication Number Publication Date
WO2011098962A2 WO2011098962A2 (fr) 2011-08-18
WO2011098962A3 true WO2011098962A3 (fr) 2012-04-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/050554 WO2011098962A2 (fr) 2010-02-09 2011-02-09 Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent

Country Status (5)

Country Link
EP (1) EP2533812A2 (fr)
JP (1) JP5950458B2 (fr)
CN (2) CN105218685B (fr)
BR (1) BR112012019580A2 (fr)
WO (1) WO2011098962A2 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2980796B1 (fr) * 2011-09-30 2014-07-04 Adocia Oligosaccharides fonctionnalises
FR2943538B1 (fr) 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
WO2012153070A1 (fr) * 2011-05-10 2012-11-15 Adocia Oligosaccharides fonctionnalisés
FR2984749A1 (fr) * 2011-12-23 2013-06-28 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 en combinaison avec une hormone gastro-intestinale a visee therapeutique
KR101810055B1 (ko) * 2011-08-10 2017-12-18 아도시아 하나 이상의 유형의 기저 인슐린의 주사액
FR2978918B1 (fr) * 2011-08-10 2013-12-27 Adocia Solution injectable a ph7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5
EP2773675B1 (fr) * 2011-11-02 2023-03-01 Adocia Formulation à action rapide d'insuline comprenant un oligosaccharide
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
CN113730555A (zh) 2012-01-09 2021-12-03 阿道恰公司 Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液
US20150314003A2 (en) 2012-08-09 2015-11-05 Adocia Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
EA034393B1 (ru) 2012-11-13 2020-02-03 Адосиа Состав инсулина быстрого действия, содержащий замещенное анионное соединение
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
WO2020002162A1 (fr) * 2018-06-29 2020-01-02 Basf Se Sels d'esteramine
CN109851683B (zh) * 2018-12-12 2021-05-11 兰州大学 一种金属配合物、一种金属配合物的制备方法和应用

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WO2007116143A1 (fr) * 2006-04-07 2007-10-18 Adocia Polysaccharides bifonctionnalises
WO2009127940A1 (fr) * 2008-04-14 2009-10-22 Adocia Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation e un support organique
WO2010058106A1 (fr) * 2008-11-19 2010-05-27 Adocia Nouvelle forme d'administration de complexes de protéines ostéogéniques

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Publication number Priority date Publication date Assignee Title
FR2861396A1 (fr) * 2003-10-24 2005-04-29 Commissariat Energie Atomique Derives amphiphiles de cyclodextrines,leur procede de preparation et leurs utilisations
WO2007116143A1 (fr) * 2006-04-07 2007-10-18 Adocia Polysaccharides bifonctionnalises
WO2009127940A1 (fr) * 2008-04-14 2009-10-22 Adocia Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation e un support organique
WO2010058106A1 (fr) * 2008-11-19 2010-05-27 Adocia Nouvelle forme d'administration de complexes de protéines ostéogéniques

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Also Published As

Publication number Publication date
WO2011098962A2 (fr) 2011-08-18
CN102834117A (zh) 2012-12-19
CN102834117B (zh) 2015-11-25
RU2012138454A (ru) 2014-03-20
BR112012019580A2 (pt) 2020-08-18
JP5950458B2 (ja) 2016-07-13
CN105218685B (zh) 2018-12-25
JP2013518978A (ja) 2013-05-23
EP2533812A2 (fr) 2012-12-19
CN105218685A (zh) 2016-01-06

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