WO2011089183A2 - Anticoagulant antidotes - Google Patents
Anticoagulant antidotes Download PDFInfo
- Publication number
- WO2011089183A2 WO2011089183A2 PCT/EP2011/050749 EP2011050749W WO2011089183A2 WO 2011089183 A2 WO2011089183 A2 WO 2011089183A2 EP 2011050749 W EP2011050749 W EP 2011050749W WO 2011089183 A2 WO2011089183 A2 WO 2011089183A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dabigatran
- seq
- antibody
- methyl
- group
- Prior art date
Links
- SJIOGTWFPQYLIF-UHFFFAOYSA-N CNc(c([NH+]([O-])[O-])c1)ccc1C(N(CCC(OC)=O)c1ccccc1)=O Chemical compound CNc(c([NH+]([O-])[O-])c1)ccc1C(N(CCC(OC)=O)c1ccccc1)=O SJIOGTWFPQYLIF-UHFFFAOYSA-N 0.000 description 1
- NKZRESTZFYZMSK-UHFFFAOYSA-N C[n]1c(ccc(C(N(CCC(NCCN)=O)c2ncccc2)=O)c2)c2nc1CNc(cc1)ccc1C(N)=N Chemical compound C[n]1c(ccc(C(N(CCC(NCCN)=O)c2ncccc2)=O)c2)c2nc1CNc(cc1)ccc1C(N)=N NKZRESTZFYZMSK-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112012018021-5A BR112012018021B1 (pt) | 2010-01-20 | 2011-01-20 | molécula de anticorpo capaz de neutralizar a atividade de dabigatrano e seu método de fabricação |
MA35080A MA33936B1 (fr) | 2010-01-20 | 2011-01-20 | Antidotes pour anticoagulants |
SG2012052445A SG182552A1 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes |
MEP-2017-29A ME02602B (me) | 2010-01-20 | 2011-01-20 | Antikoagulantni protivotrovi |
EA201201016A EA028371B1 (ru) | 2010-01-20 | 2011-01-20 | Антидоты антикоагулянтов |
AP2012006242A AP2012006242A0 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes. |
AU2011208719A AU2011208719C1 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes |
LTEP11703410.8T LT2525812T (lt) | 2010-01-20 | 2011-01-20 | Antikoaguliantų priešnuodžiai |
CA2787566A CA2787566A1 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes |
NZ599508A NZ599508A (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes |
MX2012008360A MX2012008360A (es) | 2010-01-20 | 2011-01-20 | Antidotos de anticoagulantes. |
ES11703410.8T ES2614992T3 (es) | 2010-01-20 | 2011-01-20 | Antídotos de anticoagulantes |
SI201131156A SI2525812T1 (sl) | 2010-01-20 | 2011-01-20 | Antikoagulantni antidoti |
KR1020127019086A KR101781787B1 (ko) | 2010-01-20 | 2011-01-20 | 항응고제 해독제 |
EP11703410.8A EP2525812B1 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes |
CN201180006616.4A CN102711813B (zh) | 2010-01-20 | 2011-01-20 | 抗凝血剂抗体 |
RS20170195A RS55683B1 (sr) | 2010-01-20 | 2011-01-20 | Antikoagulantni protivotrovi |
JP2012549355A JP5575923B2 (ja) | 2010-01-20 | 2011-01-20 | 抗凝固薬の解毒剤 |
UAA201209779A UA110470C2 (ru) | 2010-01-20 | 2011-01-20 | Антидот антикоагулянта |
DK11703410.8T DK2525812T3 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant. |
ZA2012/02876A ZA201202876B (en) | 2010-01-20 | 2012-04-19 | Anticoagulant antidotes |
IL219427A IL219427B (en) | 2010-01-20 | 2012-04-25 | Anticoagulant antidotes |
TNP2012000366A TN2012000366A1 (en) | 2010-01-20 | 2012-07-18 | Anticoagulant antidotes |
HK13101025.2A HK1173957A1 (en) | 2010-01-20 | 2013-01-23 | Anticoagulant antidotes |
CY20171100361T CY1118875T1 (el) | 2010-01-20 | 2017-03-22 | Αντιδοτα αντιπηκτικων |
HRP20170613TT HRP20170613T1 (hr) | 2010-01-20 | 2017-04-14 | Antikoagulacijski protuotrovi |
NL300882C NL300882I2 (nl) | 2010-01-20 | 2017-07-06 | idarucizumab |
LTPA2017021C LTC2525812I2 (lt) | 2010-01-20 | 2017-07-10 | Antikoaguliantų priešnuodžiai |
CY2017025C CY2017025I2 (el) | 2010-01-20 | 2017-07-10 | Αντιδοτα αντιπηκτικων |
FR17C1026C FR17C1026I2 (fr) | 2010-01-20 | 2017-07-10 | Antidotes d'anticoagulants |
NO2017034C NO2017034I1 (no) | 2010-01-20 | 2017-07-11 | Idarucizumab |
LU00028C LUC00028I2 (ru) | 2010-01-20 | 2017-07-12 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10151239.0 | 2010-01-20 | ||
EP10151239 | 2010-01-20 | ||
US38391410P | 2010-09-17 | 2010-09-17 | |
US61/383,914 | 2010-09-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011089183A2 true WO2011089183A2 (en) | 2011-07-28 |
WO2011089183A3 WO2011089183A3 (en) | 2011-11-17 |
Family
ID=42061991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2011/050749 WO2011089183A2 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes |
Country Status (43)
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012098089A1 (en) * | 2011-01-19 | 2012-07-26 | Bayer Pharma Aktiengesellschaft | Binding proteins to inhibitors of coagulation factors |
WO2012130834A1 (en) | 2011-03-30 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Anticoagulant antidotes |
US8486398B2 (en) | 2010-01-20 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds |
WO2015059159A1 (en) * | 2013-10-25 | 2015-04-30 | Boehringer Ingelheim International Gmbh | Anticoagulant antidotes |
EP2980218A1 (en) * | 2014-07-30 | 2016-02-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamer thrombin complex for use as an antidote to direct acting thrombin inhibitors |
US9522892B2 (en) | 2011-11-29 | 2016-12-20 | Perosphere Inc. | Anticoagulant reversal agents |
US9593166B2 (en) | 2013-03-14 | 2017-03-14 | Bayer Healthcare Llc | Monoclonal antibodies against antithrombin β |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2865068T3 (es) | 2011-01-14 | 2021-10-14 | Univ California | Anticuerpos terapéuticos contra la proteína ROR-1 y métodos para usarlos |
TW201623331A (zh) * | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法 |
CN105223348A (zh) * | 2014-05-26 | 2016-01-06 | 北京九强生物技术股份有限公司 | 人抗凝血酶iii的胶乳增强免疫比浊法检测试剂盒 |
WO2016019145A1 (en) * | 2014-07-31 | 2016-02-04 | Haemonetics Corporation | Detection and classification of an anticoagulant using a clotting assay |
WO2016044645A1 (en) * | 2014-09-17 | 2016-03-24 | Elmaleh David R | Anticoagulant derivatives for cardiovascular imaging |
WO2016107605A1 (zh) | 2014-12-31 | 2016-07-07 | 昆明积大制药股份有限公司 | 药物组合物及其制备方法 |
US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
IL275453B1 (en) * | 2017-12-24 | 2024-02-01 | Noile Immune Biotech Inc | An immunocompetent cell expressing a cell surface compound that specifically recognizes human mesothelin, IL-7, and CCL19 |
US11873341B2 (en) | 2018-03-13 | 2024-01-16 | Tusk Therapeutics Ltd. | Anti-CD25 for tumour specific cell depletion |
JP7407742B2 (ja) * | 2018-05-11 | 2024-01-04 | ハルシオン セラピューティクス インコーポレイテッド | Gasp-1顆粒を標的とする結合性タンパク質及びキメラ抗原受容体t細胞並びにそれらの使用 |
KR20210086682A (ko) | 2018-10-29 | 2021-07-08 | 화하이 유에스 인코퍼레이티드 | 신규한 디펩티드 화합물과 이의 용도 |
WO2020180489A1 (en) | 2019-03-06 | 2020-09-10 | University Of Rochester | Anticoagulant compositions and uses thereof |
CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
TW202321311A (zh) * | 2021-08-02 | 2023-06-01 | 日商諾伊爾免疫生物科技股份有限公司 | 與scFv等之連接子結合的抗體 |
US11446286B1 (en) * | 2022-02-28 | 2022-09-20 | King Faisal University | Treatment of fungal infections using dabigatran etexilate |
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WO1988001649A1 (en) | 1986-09-02 | 1988-03-10 | Genex Corporation | Single polypeptide chain binding molecules |
WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
WO1991017271A1 (en) | 1990-05-01 | 1991-11-14 | Affymax Technologies N.V. | Recombinant library screening methods |
WO1994004678A1 (en) | 1992-08-21 | 1994-03-03 | Casterman Cecile | Immunoglobulins devoid of light chains |
WO1994013804A1 (en) | 1992-12-04 | 1994-06-23 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
WO1994029348A2 (en) | 1993-06-03 | 1994-12-22 | Therapeutic Antibodies Inc. | Production of antibody fragments |
WO1998025971A1 (en) | 1996-12-10 | 1998-06-18 | Celltech Therapeutics Limited | Monovalent antibody fragments |
WO1998037075A1 (de) | 1997-02-18 | 1998-08-27 | Boehringer Ingelheim Pharma Kg | Disubstituierte bicyclische heterocyclen, ihre herstellung und ihre verwendung als arzneimittel |
US5817309A (en) | 1992-02-11 | 1998-10-06 | Max-Planck-Gesellschaft | Antidote for hirudin and synthetic thrombin inhibitors and method of use |
WO1998048837A1 (en) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Polyalkylene oxide-modified single chain polypeptides |
US6060300A (en) | 1996-02-12 | 2000-05-09 | Basf Aktiengesellschaft | Thrombin muteins as antidotes for thrombin inhibitors |
US6086871A (en) | 1995-06-13 | 2000-07-11 | Baxter Aktiengesellschaft | Prothrombin derivatives |
US6200955B1 (en) | 1996-06-11 | 2001-03-13 | Commonwealth Biotechnologies, Inc. | Heparin binding peptides |
WO2001079258A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
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WO2003050531A2 (en) | 2001-12-11 | 2003-06-19 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
US6624141B1 (en) | 1999-03-17 | 2003-09-23 | The Regents Of The University Of Michigan | Protamine fragment compositions and methods of use |
WO2004003019A2 (en) | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
WO2004041865A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Stabilized single domain antibodies |
WO2004081026A2 (en) | 2003-06-30 | 2004-09-23 | Domantis Limited | Polypeptides |
WO2009042962A2 (en) | 2007-09-28 | 2009-04-02 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
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US6087380A (en) | 1949-11-24 | 2000-07-11 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
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DE19729544A1 (de) * | 1997-07-10 | 1999-01-14 | Basf Ag | Ancrod spezifische monoklonale Antikörper, Antikörperfragmente, deren Mischung oder Derivate und deren Verwendung |
US6440417B1 (en) | 1998-11-06 | 2002-08-27 | Conjuchem, Inc. | Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments |
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US20070031438A1 (en) * | 2001-12-10 | 2007-02-08 | Junghans Richard P | Antibodies as chimeric effector cell receptors against tumor antigens |
AR070141A1 (es) * | 2008-01-23 | 2010-03-17 | Glenmark Pharmaceuticals Sa | Anticuerpos humanizados especificos para el factor von willebrand |
ES2436076T3 (es) | 2009-08-24 | 2013-12-26 | Boehringer Ingelheim International Gmbh | Intervenciones de urgencia de carbón vegetal activo con sobredosificación con etexilato de dabigatrán |
AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
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2011
- 2011-01-19 AR ARP110100179A patent/AR079944A1/es active IP Right Grant
- 2011-01-19 TW TW100102006A patent/TWI513466B/zh active
- 2011-01-20 UY UY0001033196A patent/UY33196A/es active IP Right Grant
- 2011-01-20 MX MX2012008360A patent/MX2012008360A/es active IP Right Grant
- 2011-01-20 CN CN201180006616.4A patent/CN102711813B/zh active Active
- 2011-01-20 MA MA35080A patent/MA33936B1/fr unknown
- 2011-01-20 US US13/010,403 patent/US8486398B2/en active Active
- 2011-01-20 SG SG2012052445A patent/SG182552A1/en unknown
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