WO2011070600A1 - Appareil de stérilisation et de désinfection - Google Patents

Appareil de stérilisation et de désinfection Download PDF

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Publication number
WO2011070600A1
WO2011070600A1 PCT/IT2009/000558 IT2009000558W WO2011070600A1 WO 2011070600 A1 WO2011070600 A1 WO 2011070600A1 IT 2009000558 W IT2009000558 W IT 2009000558W WO 2011070600 A1 WO2011070600 A1 WO 2011070600A1
Authority
WO
WIPO (PCT)
Prior art keywords
sterilisation
hydrogen peroxide
environment
vhp
concentration
Prior art date
Application number
PCT/IT2009/000558
Other languages
English (en)
Inventor
Angelo Silvestri
Andrea Minari
Original Assignee
Sidel S.P.A. Con Socio Unico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidel S.P.A. Con Socio Unico filed Critical Sidel S.P.A. Con Socio Unico
Priority to EP09802034A priority Critical patent/EP2509641A1/fr
Priority to US13/514,149 priority patent/US20130028794A1/en
Priority to CN2009801628602A priority patent/CN102802678A/zh
Priority to PCT/IT2009/000558 priority patent/WO2011070600A1/fr
Priority to JP2012542689A priority patent/JP2013513420A/ja
Publication of WO2011070600A1 publication Critical patent/WO2011070600A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/24—Apparatus using programmed or automatic operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment
    • A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour

Definitions

  • the present invention relates to a sterilisation and disinfection apparatus, particularly for the decontamination of food packaging items, such as caps and pre-forms of a thermoplastic material (e.g. of polyethylene terephthalate, polypropylene, etc.) for the manufacture, by a process of blowing or stretching- blowing, of containers, such as bottles, flasks and the like.
  • a thermoplastic material e.g. of polyethylene terephthalate, polypropylene, etc.
  • VHP vaporised hydrogen peroxide
  • VHP is currently used in sterilising and disinfection processes for items such as pharmaceutical basic materials and end products, as well as food packaging items.
  • VHP in a specific concentration is supplied, at a certain pressure into a treatment vessel wherein items to be treated (e.g. packaging materials) are stored, to sterilize and disinfect those items by the action of nascent oxygen and radicals .
  • VHP concentration in the treatment vessel drops as the VHP comes into contact with both items to be treated and the wall of the vessel. Sterilization and disinfection thus becomes ineffective when the VHP concentration falls below a threshold level .
  • VHP concentration in a treatment vessel should rather be controlled and maintained within a predetermined range and long enough to effect sterilization of objects within the vessel.
  • the VHP concentration in the treatment vessel needs to be monitored in real time and with high precision as a sterilisation process proceeds.
  • a number of methods for detecting the concentration of VHP are known, such as controlled potential electrolysis, test-paper photoelectric photometry, and use of detection tubes, which do not enable real-time detection of VHP and are, accordingly, unsuitable for the purposes described above.
  • optical and optochemical sensors which are capable of detecting hydrogen peroxide in the 0.1 to 10.0 mM concentration range, with great precision.
  • their working principle is based on the decomposition of hydrogen peroxide in the presence of a catalyst and on the indirect measurement of the oxygen thereby produced through quenching of the fluorescence of a silica gel- adsorbed dye entrapped in silicone rubber.
  • ⁇ these sensors are extremely costly, sophisticated and delicate, therefore, despite their detection accuracy, their use in a sterilisation and disinfection apparatus is not industrially viable.
  • a sterilisation and disinfection apparatus which enables monitoring in real-time the concentration of VHP as a sterilisation process proceeds, thereby improving the control accuracy thereof and eliminating, or at least significantly reducing, the loss entailed by the use of costly reagents in excess.
  • sterilisation and disinfection apparatuses comprise distinct sources of hydrogen peroxide and of sterile air, respectively, and a mixing device, e.g. a Venturi type device, wherein hydrogen peroxide, which is most commonly available as a solution in water having a predetermined titre, is atomised and mixed with sterile or not sterile air to form a feed mixture.
  • a mixing device e.g. a Venturi type device, wherein hydrogen peroxide, which is most commonly available as a solution in water having a predetermined titre, is atomised and mixed with sterile or not sterile air to form a feed mixture.
  • This feed mixture is subsequently submitted to an evaporator, wherein hydrogen peroxide is vaporised, a gaseous dispersion of vaporised hydrogen peroxide (VHP) thereby being obtained.
  • VHP vaporised hydrogen peroxide
  • the VHP concentration in the gaseous dispersion can be set at the desired value.
  • the reaction by which hydrogen peroxide decomposes exothermically into water and oxygen, which is at the basis of its sterilising action is greatly favoured thermodynamically .
  • commercial grades of hydrogen peroxide are quite stable, typically losing less than 1% relative strength per year, several factors can increase the normally slow rate of hydrogen peroxide decomposition.
  • temperature of the hydrogen peroxide aqueous solution is an important variable, since the decomposition rate is roughly doubled by every 10°C increase.
  • VHP also comprises radical species which are not to be found in a hydrogen peroxide aqueous solution.
  • the gaseous dispersion obtained from the evaporator is generally not fed into a hermetically sealed vessel containing the items to be sterilised, but rather into a sterilisation and disinfection tunnel through which pre-forms are moved from an entrance to an exit of the tunnel, i.e. along a sterilisation path defined by the tunnel itself, the VHP concentration being generally not constant along said path.
  • a sub-atmospheric pressure is generally maintained within the tunnel .
  • Number 1 in Figure 1 indicates as a whole a sterilisation and disinfection apparatus, particularly for sterilising/disinfecting items 2 to be sterilised, such as caps, pre-forms and bottles of a thermoplastic material.
  • apparatus 1 comprises a sterilisation environment 3 into which the items 2 to be sterilised are successively fed, e.g. by means of a conveyor belt or other transfer devices, and through which said items 2 advance as they are sterilised.
  • Figure 1' also shows sterilised times 2' as they are conveyed out of the sterilisation apparatus.
  • Sterilisation and disinfection apparatus 1 comprises a source 4 of hydrogen peroxide in aqueous solution having a predetermined titre, and a source 5 of sterile air. Furthermore, apparatus 1 comprises means for feeding a predetermined flow of hydrogen peroxide and a predetermined flow of sterile air towards the sterilisation environment 3. More particularly, apparatus 1 comprises a mixing device 6, such as a Venturi-type mixer, fluidically connected with both sources 4 and 5, and designed to suction in and atomise the hydrogen peroxide aqueous solution, sterile air being fed to mixing device 6 functioning as the driving fluid. A- gaseous dispersion of atomised liquid hydrogen peroxide in sterile air is thereby obtainable at the exit of mixing device 6.
  • a mixing device 6 such as a Venturi-type mixer
  • Apparatus 1 further comprises an evaporator 7 comprised between, and fluidically connected to, mixing device 6 and sterilisation environment 3, which is designed to receive the flow of the gaseous dispersion obtained at the exit of mixing device 6 and to vaporise the hydrogen peroxide aqueous solution contained therein, thereby producing as an output a flow of a gaseous dispersion of vaporised hydrogen peroxide (VHP) in sterile air, which may be used as a sterilising agent in the sterilisation environment 3.
  • VHP vaporised hydrogen peroxide
  • apparatus '1 further comprises sensing means S for detecting a VHP/H 2 O 2 concentration between evaporator 7 and sterilisation environment 3.
  • sensing means S comprise at least a sensing element, or sensor 8 whose surface is capable of chemically adsorbing VHP/H 2 O 2 , the electro-conductivity of the sensing element varying as a function of the amount of VHP adsorbed and, in turn, of the VHP concentration in the gaseous atmosphere the sensing element is exposed to; and a means for heating (directly or indirectly) the sensor element.
  • a variation of the electro-conductivity of the sensing element in response to a variation of the VHP/H 2 O2 concentration is detected as a variation of the resistance in an electric circuit.
  • an increase in electro-conductivity, i.e. a decrease in resistance is converted into the increase in voltage in an electric circuit, which may be promptly detected with a virtually negligible delay.
  • a change in the output of sensing means 8 promptly reflects a change in VHP concentration.
  • the sensing element comprises a semiconductor material, such as a semiconductor oxide, e.g. Sn0 2 , ZnO, NiO, Mn0 2 .
  • a semiconductor oxide e.g. Sn0 2 , ZnO, NiO, Mn0 2 .
  • the adsorbed oxygen species form a potential barrier which affects, the electrical resistance of the semiconductor material and, in turn, of the sensing element of sensing means 8.
  • the variation of electro- conductivity on contact with VHP/H 2 0 2 i.e. the inversely proportional variation of electric resistance of the sensor 8 is converted into a voltage variation in an electric circuit and is output.
  • the output signal of sensing means 8 which is a function ' of an electric entity, may be then advantageously converted into a value of VHP/H 2 O 2 concentration, of which the non-converted output signal serves as an indirect measurement.
  • a conversion rate may be experimentally obtained by measuring the sensor outputs at different known VHP/H 2 O 2 concentrations in an experiment vessel wherein temperature and humidity are maintained at a constant level .
  • Semiconductor oxide sensors have been found to be responsive to VHP concentrations in the range 5000 ⁇ 70 , 000 ppm, which is typical of sterilisation operations in pharmaceutical and food industry. Through accurate calibration a reliable output signal/VHP concentration conversion rate is obtained.
  • the sensor element is heated at temperatures in the range 200 ⁇ 400 °C to accelerate the rate of adsorption of VHP and oxygen to, and desorption from, the surface of the semiconductor material to enhance the gas detection response speed.
  • the sterilisation/disinfection apparatus 1 shall also comprise an exhaust line 9 to discharge an exhaust gas containing VHP residues from the sterilisation environment 3 and to means (not shown) for its after- treatment. Since hydrogen peroxide may become involved in a number of photochemical reactions with hydrocarbons and nitrogen oxides present in the atmosphere, thereby potentially leading to the formation of very harmful pollutant species, the gaseous current leaving sterilisation environment 3 cannot be released as such. ⁇
  • the sterilisation environment 3 may be a sealed vessel suitable for receiving items to be sterilised at the beginning of a batch sterilisation cycle.
  • the sterilisation environment 3 is defined internally by a non-sealed sterilisation tunnel, having an entrance and an exit, into which tunnel a succession of items to be sterilised, such as pre-forms and caps, are fed along a sterilisation path.
  • sterilisation tunnels are operated at a pressure slightly below atmospheric pressure at the interfaces, so that VHP leakages are prevented.
  • the sterile zone is maintained at a pressure above atmospheric pressure in order to prevent any contamination potentially carried by not sterile external air.
  • VHP-containing atmosphere As they proceed through the sterilisation tunnel, items come into contact with the VHP-containing atmosphere and are progressively sterilised as they approach the exit of the tunnel. Accordingly, since hydrogen peroxide decomposes into water and oxygen as it exerts its sterilising action upon the items to be sterilised, a VHP concentration gradient is generally established along the sterilisation path.
  • VHP concentration of the gaseous . dispersion fed into the tunnel and speed of advancement 'of the items through the tunnel shall be set so as to ensure sufficient exposure to the sterilising action of VHP.
  • the sterilisation and disinfection apparatus 1 advantageously comprises at least two further sensors- 8', 8'' of the type described above and located within the sterilisation tunnel, at corresponding distinct positions along the sterilisation path.
  • Sensors 8 ' , 8 ' ' independently detect VHP - concentration at their respective distinct positions within sterilisation environment 3.
  • sensor 8'' is placed proximal to the exit of the sterilisation tunnel .
  • the output signals of sensors, 8', 8'' can be elaborated into information on a variation of VHP concentration within the sterilisation environment 3 as items to be sterilised advance therethrough, i.e. as sterilisation proceeds.
  • this information may be used to assess whether at least a minimum threshold value of VHP concentration is always maintained along the whole of the sterilisation path, i.e. if the whole of the sterilisation path is effectively used for the purpose of sterilisation. If too low a VHP concentration were to be detected upstream of the exit of the sterilisation tunnel, it would appear that a portion of the tunnel proximal to ' the exit .is substantially inactive. In other words, a portion of the sterilisation environment 3 would appear to be operated non-efficiently.
  • the differential data obtainable by elaborating the output signals of sensors 8', 8'' indirectly provides information on the suitability of the VHP concentration set in the sterilisation environment and the exposure time in the sterilisation environment 3, which depends on the speed at which items are advanced in the case of a sterilisation tunnel.
  • the sterilisation and disinfection apparatus 1 comprises a control unit (not shown) which is configured to receive from the sensing means S at least one output signal and elaborate, on the basis thereof, a control signal in response to which actuating means may vary one or more process parameters, such as the mass , flow of hydrogen peroxide aqueous solution, the mass flow of sterile air, the speed at which items to be sterilised are advanced through the sterilisation environment 3 (or the permanence time therein, in the case of a static batch-like operation).
  • process parameters such as the mass , flow of hydrogen peroxide aqueous solution, the mass flow of sterile air, the speed at which items to be sterilised are advanced through the sterilisation environment 3 (or the permanence time therein, in the case of a static batch-like operation).
  • a controlled flow of hydrogen peroxide aqueous solution is suctioned from source 4 into the mixing device 6 by the driving action of a controlled carrier flow of sterile air supplied from source 5.
  • the resulting dispersion of atomised hydrogen peroxide is heated in evaporator 7 , hydrogen peroxide being thereby vaporised.
  • the resulting VHP gaseous, dispersion is fed to the sterilising environment 3 to serve as the sterilising agent.
  • Sensing means 8 detects VHP concentration upstream from the sterilisation environment 3.
  • a first check is carried out to ensure that the gaseous dispersion fed -into the sterilisation environment 3 does have the expected VHP concentration and is therefore capable of exerting on items 2 the necessary sterilising action.
  • the control unit may act, in response to the output signal of sensor 8, on either the mass flow rate of hydrogen peroxide aqueous solution or the sterile air flow rate with a view to adjusting the VHP concentration value upstream from the sterilisation environment.
  • a decrease in the titre of the hydrogen peroxide aqueous solution due e.g.
  • sensor 8 detects a VHP concentration lower than an alarm threshold value, an alarm signal is submitted to the control unit which, in response to this signal, proceeds to interrupt the feed of items 2 to be sterilised to the sterilisation environment 3, at least until conditions for effective sterilisation in the sterilisation environment 3 are restored.
  • sensors 8' and 8'' detect VHP concentration at least at two distinct positions within the sterilisation environment.
  • a second ' check is carried out to ensure that at least a minimum VHP concentration is maintained in the sterilisation environment 3. This may be of particular relevance when the sterilisation environment 3 is large and not hermetically sealed, and even more so if the sterilisation environment 3 is maintained below atmospheric pressure, since the local VHP concentration may differ from the VHP concentration detected upstream by sensor 8, e.g. due to accidental infiltrations or contaminations.
  • a third check is carried out, based on the differential information obtained from the elaboration of the output signals of sensors 8', 8'', to ensure that VHP consumption along the sterilisation path, i.e. as sterilisation progresses, is greater than a threshold value corresponding to a sufficient exposure to the sterilising agent.
  • this third check it may be ensured that all items advancing through the sterilisation environment 3 are exposed to enough sterilising agent and for long enough to achieve the intended sterilised condition.
  • control unit may act, in response to the output signals of sensors 8' and 8'', on either the mass flow rate of hydrogen peroxide aqueous solution or the sterile air flow rate with a view to adjusting the VHP concentration value upstream from the sterilisation environment.
  • an insufficient VHP concentration within the sterilisation environment 3 may be compensated by supplying more hydrogen peroxide.
  • control unit may act, in response to the output signals of sensors 8' and 8' ', on the speed at which items 2 are fed into the sterilisation environment 3 or on the permanence time of items 2 within sterilisation environment 3, when batch-like operated.
  • the sterilisation and disinfection apparatus of the invention enables accurately controlled and effective sterilisation whilst reducing manufacturing and management costs, since the use of excess hydrogen peroxide is significantly limited and the semiconductor oxide sensors are commercially available at prices remarkably lower than other more sophisticated sensors for detecting hydrogen peroxide. Furthermore, real-time monitoring of VHP concentration at different locations along the sterilisation path enables precise control of operating conditions and, consequently, very high standards of hygiene and safety for the sterilised items.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention porte sur un appareil de stérilisation et de désinfection (1) qui comporte un environnement de stérilisation (3) pour recevoir des articles (2) à stériliser, une source (4) de peroxyde d'hydrogène et des moyens (5, 6, 7) d'acheminement, vers ledit environnement de stérilisation (3), d'un flux régulé d'une dispersion gazeuse de peroxyde d'hydrogène vaporisé, ledit appareil étant caractérisé en ce qu'il comporte un moyen de détection (S) dont la conductivité électrique varie en réponse à une variation de la concentration de peroxyde d'hydrogène vaporisé dans l'atmosphère gazeux auquel ledit moyen de détection (S) est exposé, ledit moyen de détection (S) étant exposé à ladite dispersion gazeuse et configuré pour émettre un signal en fonction de la concentration de peroxyde d'hydrogène vaporisé dans ladite dispersion gazeuse.
PCT/IT2009/000558 2009-12-10 2009-12-10 Appareil de stérilisation et de désinfection WO2011070600A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP09802034A EP2509641A1 (fr) 2009-12-10 2009-12-10 Appareil de stérilisation et de désinfection
US13/514,149 US20130028794A1 (en) 2009-12-10 2009-12-10 Sterilising and disinfection apparatus
CN2009801628602A CN102802678A (zh) 2009-12-10 2009-12-10 杀菌消毒装置
PCT/IT2009/000558 WO2011070600A1 (fr) 2009-12-10 2009-12-10 Appareil de stérilisation et de désinfection
JP2012542689A JP2013513420A (ja) 2009-12-10 2009-12-10 滅菌および消毒装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2009/000558 WO2011070600A1 (fr) 2009-12-10 2009-12-10 Appareil de stérilisation et de désinfection

Publications (1)

Publication Number Publication Date
WO2011070600A1 true WO2011070600A1 (fr) 2011-06-16

Family

ID=42066471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2009/000558 WO2011070600A1 (fr) 2009-12-10 2009-12-10 Appareil de stérilisation et de désinfection

Country Status (5)

Country Link
US (1) US20130028794A1 (fr)
EP (1) EP2509641A1 (fr)
JP (1) JP2013513420A (fr)
CN (1) CN102802678A (fr)
WO (1) WO2011070600A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN110191870A (zh) * 2017-01-11 2019-08-30 通用电气公司 使用SiGa和/或Siln合金的熔渗法

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CN103662198A (zh) * 2013-11-12 2014-03-26 苏州苏东庭生物科技有限公司 酒瓶消毒箱
JP6439920B2 (ja) * 2013-11-14 2018-12-19 大日本印刷株式会社 ボトルの殺菌方法及び装置
JP6473057B2 (ja) * 2015-07-23 2019-02-20 三菱重工機械システム株式会社 殺菌剤の気化方法及び気化装置
CN106075516A (zh) * 2016-07-26 2016-11-09 张剑 一种压力蒸汽灭菌过程验证装置及其灭菌效果监测方法
DE102016125027A1 (de) * 2016-12-20 2018-06-21 Krones Ag Vorrichtung zum Behandeln von Anlagenkomponenten und/oder Packmitteln mit verdampftem Wasserstoffperoxid
CN114617999A (zh) 2017-03-27 2022-06-14 里珍纳龙药品有限公司 灭菌方法
CN108686241B (zh) * 2017-04-10 2021-03-26 山东新华医疗器械股份有限公司 灭菌方法和灭菌装置
JP7228950B2 (ja) * 2017-06-05 2023-02-27 四国化工機株式会社 容器の殺菌方法
CN109550180A (zh) * 2018-12-07 2019-04-02 北京欣迪康泰科技有限公司 一种消除封闭环境中g类化学毒剂的方法
IT202000003883A1 (it) * 2020-02-25 2021-08-25 Comecer Spa Metodo e impianto per decontaminare in continuo contenitori rigidi

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WO1998000176A1 (fr) * 1996-07-03 1998-01-08 American Sterilizer Company Controle de regulation de procedes de sterilisation avec des modules de detection semi-conducteurs
GB2331810A (en) * 1997-11-28 1999-06-02 Taiyo Toyo Sanso Co Ltd Temperature and humidity compensation for a semiconductor gas sensor
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Publication number Priority date Publication date Assignee Title
CN110191870A (zh) * 2017-01-11 2019-08-30 通用电气公司 使用SiGa和/或Siln合金的熔渗法

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EP2509641A1 (fr) 2012-10-17
CN102802678A (zh) 2012-11-28
JP2013513420A (ja) 2013-04-22
US20130028794A1 (en) 2013-01-31

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