WO2011070600A1 - Appareil de stérilisation et de désinfection - Google Patents
Appareil de stérilisation et de désinfection Download PDFInfo
- Publication number
- WO2011070600A1 WO2011070600A1 PCT/IT2009/000558 IT2009000558W WO2011070600A1 WO 2011070600 A1 WO2011070600 A1 WO 2011070600A1 IT 2009000558 W IT2009000558 W IT 2009000558W WO 2011070600 A1 WO2011070600 A1 WO 2011070600A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sterilisation
- hydrogen peroxide
- environment
- vhp
- concentration
- Prior art date
Links
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 134
- 230000001954 sterilising effect Effects 0.000 title description 20
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 108
- 239000006185 dispersion Substances 0.000 claims abstract description 20
- 230000004044 response Effects 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 11
- 239000001301 oxygen Substances 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 239000004065 semiconductor Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000013078 crystal Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 238000005036 potential barrier Methods 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- -1 polyethylene terephthalate Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000012815 thermoplastic material Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
- A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
Definitions
- the present invention relates to a sterilisation and disinfection apparatus, particularly for the decontamination of food packaging items, such as caps and pre-forms of a thermoplastic material (e.g. of polyethylene terephthalate, polypropylene, etc.) for the manufacture, by a process of blowing or stretching- blowing, of containers, such as bottles, flasks and the like.
- a thermoplastic material e.g. of polyethylene terephthalate, polypropylene, etc.
- VHP vaporised hydrogen peroxide
- VHP is currently used in sterilising and disinfection processes for items such as pharmaceutical basic materials and end products, as well as food packaging items.
- VHP in a specific concentration is supplied, at a certain pressure into a treatment vessel wherein items to be treated (e.g. packaging materials) are stored, to sterilize and disinfect those items by the action of nascent oxygen and radicals .
- VHP concentration in the treatment vessel drops as the VHP comes into contact with both items to be treated and the wall of the vessel. Sterilization and disinfection thus becomes ineffective when the VHP concentration falls below a threshold level .
- VHP concentration in a treatment vessel should rather be controlled and maintained within a predetermined range and long enough to effect sterilization of objects within the vessel.
- the VHP concentration in the treatment vessel needs to be monitored in real time and with high precision as a sterilisation process proceeds.
- a number of methods for detecting the concentration of VHP are known, such as controlled potential electrolysis, test-paper photoelectric photometry, and use of detection tubes, which do not enable real-time detection of VHP and are, accordingly, unsuitable for the purposes described above.
- optical and optochemical sensors which are capable of detecting hydrogen peroxide in the 0.1 to 10.0 mM concentration range, with great precision.
- their working principle is based on the decomposition of hydrogen peroxide in the presence of a catalyst and on the indirect measurement of the oxygen thereby produced through quenching of the fluorescence of a silica gel- adsorbed dye entrapped in silicone rubber.
- ⁇ these sensors are extremely costly, sophisticated and delicate, therefore, despite their detection accuracy, their use in a sterilisation and disinfection apparatus is not industrially viable.
- a sterilisation and disinfection apparatus which enables monitoring in real-time the concentration of VHP as a sterilisation process proceeds, thereby improving the control accuracy thereof and eliminating, or at least significantly reducing, the loss entailed by the use of costly reagents in excess.
- sterilisation and disinfection apparatuses comprise distinct sources of hydrogen peroxide and of sterile air, respectively, and a mixing device, e.g. a Venturi type device, wherein hydrogen peroxide, which is most commonly available as a solution in water having a predetermined titre, is atomised and mixed with sterile or not sterile air to form a feed mixture.
- a mixing device e.g. a Venturi type device, wherein hydrogen peroxide, which is most commonly available as a solution in water having a predetermined titre, is atomised and mixed with sterile or not sterile air to form a feed mixture.
- This feed mixture is subsequently submitted to an evaporator, wherein hydrogen peroxide is vaporised, a gaseous dispersion of vaporised hydrogen peroxide (VHP) thereby being obtained.
- VHP vaporised hydrogen peroxide
- the VHP concentration in the gaseous dispersion can be set at the desired value.
- the reaction by which hydrogen peroxide decomposes exothermically into water and oxygen, which is at the basis of its sterilising action is greatly favoured thermodynamically .
- commercial grades of hydrogen peroxide are quite stable, typically losing less than 1% relative strength per year, several factors can increase the normally slow rate of hydrogen peroxide decomposition.
- temperature of the hydrogen peroxide aqueous solution is an important variable, since the decomposition rate is roughly doubled by every 10°C increase.
- VHP also comprises radical species which are not to be found in a hydrogen peroxide aqueous solution.
- the gaseous dispersion obtained from the evaporator is generally not fed into a hermetically sealed vessel containing the items to be sterilised, but rather into a sterilisation and disinfection tunnel through which pre-forms are moved from an entrance to an exit of the tunnel, i.e. along a sterilisation path defined by the tunnel itself, the VHP concentration being generally not constant along said path.
- a sub-atmospheric pressure is generally maintained within the tunnel .
- Number 1 in Figure 1 indicates as a whole a sterilisation and disinfection apparatus, particularly for sterilising/disinfecting items 2 to be sterilised, such as caps, pre-forms and bottles of a thermoplastic material.
- apparatus 1 comprises a sterilisation environment 3 into which the items 2 to be sterilised are successively fed, e.g. by means of a conveyor belt or other transfer devices, and through which said items 2 advance as they are sterilised.
- Figure 1' also shows sterilised times 2' as they are conveyed out of the sterilisation apparatus.
- Sterilisation and disinfection apparatus 1 comprises a source 4 of hydrogen peroxide in aqueous solution having a predetermined titre, and a source 5 of sterile air. Furthermore, apparatus 1 comprises means for feeding a predetermined flow of hydrogen peroxide and a predetermined flow of sterile air towards the sterilisation environment 3. More particularly, apparatus 1 comprises a mixing device 6, such as a Venturi-type mixer, fluidically connected with both sources 4 and 5, and designed to suction in and atomise the hydrogen peroxide aqueous solution, sterile air being fed to mixing device 6 functioning as the driving fluid. A- gaseous dispersion of atomised liquid hydrogen peroxide in sterile air is thereby obtainable at the exit of mixing device 6.
- a mixing device 6 such as a Venturi-type mixer
- Apparatus 1 further comprises an evaporator 7 comprised between, and fluidically connected to, mixing device 6 and sterilisation environment 3, which is designed to receive the flow of the gaseous dispersion obtained at the exit of mixing device 6 and to vaporise the hydrogen peroxide aqueous solution contained therein, thereby producing as an output a flow of a gaseous dispersion of vaporised hydrogen peroxide (VHP) in sterile air, which may be used as a sterilising agent in the sterilisation environment 3.
- VHP vaporised hydrogen peroxide
- apparatus '1 further comprises sensing means S for detecting a VHP/H 2 O 2 concentration between evaporator 7 and sterilisation environment 3.
- sensing means S comprise at least a sensing element, or sensor 8 whose surface is capable of chemically adsorbing VHP/H 2 O 2 , the electro-conductivity of the sensing element varying as a function of the amount of VHP adsorbed and, in turn, of the VHP concentration in the gaseous atmosphere the sensing element is exposed to; and a means for heating (directly or indirectly) the sensor element.
- a variation of the electro-conductivity of the sensing element in response to a variation of the VHP/H 2 O2 concentration is detected as a variation of the resistance in an electric circuit.
- an increase in electro-conductivity, i.e. a decrease in resistance is converted into the increase in voltage in an electric circuit, which may be promptly detected with a virtually negligible delay.
- a change in the output of sensing means 8 promptly reflects a change in VHP concentration.
- the sensing element comprises a semiconductor material, such as a semiconductor oxide, e.g. Sn0 2 , ZnO, NiO, Mn0 2 .
- a semiconductor oxide e.g. Sn0 2 , ZnO, NiO, Mn0 2 .
- the adsorbed oxygen species form a potential barrier which affects, the electrical resistance of the semiconductor material and, in turn, of the sensing element of sensing means 8.
- the variation of electro- conductivity on contact with VHP/H 2 0 2 i.e. the inversely proportional variation of electric resistance of the sensor 8 is converted into a voltage variation in an electric circuit and is output.
- the output signal of sensing means 8 which is a function ' of an electric entity, may be then advantageously converted into a value of VHP/H 2 O 2 concentration, of which the non-converted output signal serves as an indirect measurement.
- a conversion rate may be experimentally obtained by measuring the sensor outputs at different known VHP/H 2 O 2 concentrations in an experiment vessel wherein temperature and humidity are maintained at a constant level .
- Semiconductor oxide sensors have been found to be responsive to VHP concentrations in the range 5000 ⁇ 70 , 000 ppm, which is typical of sterilisation operations in pharmaceutical and food industry. Through accurate calibration a reliable output signal/VHP concentration conversion rate is obtained.
- the sensor element is heated at temperatures in the range 200 ⁇ 400 °C to accelerate the rate of adsorption of VHP and oxygen to, and desorption from, the surface of the semiconductor material to enhance the gas detection response speed.
- the sterilisation/disinfection apparatus 1 shall also comprise an exhaust line 9 to discharge an exhaust gas containing VHP residues from the sterilisation environment 3 and to means (not shown) for its after- treatment. Since hydrogen peroxide may become involved in a number of photochemical reactions with hydrocarbons and nitrogen oxides present in the atmosphere, thereby potentially leading to the formation of very harmful pollutant species, the gaseous current leaving sterilisation environment 3 cannot be released as such. ⁇
- the sterilisation environment 3 may be a sealed vessel suitable for receiving items to be sterilised at the beginning of a batch sterilisation cycle.
- the sterilisation environment 3 is defined internally by a non-sealed sterilisation tunnel, having an entrance and an exit, into which tunnel a succession of items to be sterilised, such as pre-forms and caps, are fed along a sterilisation path.
- sterilisation tunnels are operated at a pressure slightly below atmospheric pressure at the interfaces, so that VHP leakages are prevented.
- the sterile zone is maintained at a pressure above atmospheric pressure in order to prevent any contamination potentially carried by not sterile external air.
- VHP-containing atmosphere As they proceed through the sterilisation tunnel, items come into contact with the VHP-containing atmosphere and are progressively sterilised as they approach the exit of the tunnel. Accordingly, since hydrogen peroxide decomposes into water and oxygen as it exerts its sterilising action upon the items to be sterilised, a VHP concentration gradient is generally established along the sterilisation path.
- VHP concentration of the gaseous . dispersion fed into the tunnel and speed of advancement 'of the items through the tunnel shall be set so as to ensure sufficient exposure to the sterilising action of VHP.
- the sterilisation and disinfection apparatus 1 advantageously comprises at least two further sensors- 8', 8'' of the type described above and located within the sterilisation tunnel, at corresponding distinct positions along the sterilisation path.
- Sensors 8 ' , 8 ' ' independently detect VHP - concentration at their respective distinct positions within sterilisation environment 3.
- sensor 8'' is placed proximal to the exit of the sterilisation tunnel .
- the output signals of sensors, 8', 8'' can be elaborated into information on a variation of VHP concentration within the sterilisation environment 3 as items to be sterilised advance therethrough, i.e. as sterilisation proceeds.
- this information may be used to assess whether at least a minimum threshold value of VHP concentration is always maintained along the whole of the sterilisation path, i.e. if the whole of the sterilisation path is effectively used for the purpose of sterilisation. If too low a VHP concentration were to be detected upstream of the exit of the sterilisation tunnel, it would appear that a portion of the tunnel proximal to ' the exit .is substantially inactive. In other words, a portion of the sterilisation environment 3 would appear to be operated non-efficiently.
- the differential data obtainable by elaborating the output signals of sensors 8', 8'' indirectly provides information on the suitability of the VHP concentration set in the sterilisation environment and the exposure time in the sterilisation environment 3, which depends on the speed at which items are advanced in the case of a sterilisation tunnel.
- the sterilisation and disinfection apparatus 1 comprises a control unit (not shown) which is configured to receive from the sensing means S at least one output signal and elaborate, on the basis thereof, a control signal in response to which actuating means may vary one or more process parameters, such as the mass , flow of hydrogen peroxide aqueous solution, the mass flow of sterile air, the speed at which items to be sterilised are advanced through the sterilisation environment 3 (or the permanence time therein, in the case of a static batch-like operation).
- process parameters such as the mass , flow of hydrogen peroxide aqueous solution, the mass flow of sterile air, the speed at which items to be sterilised are advanced through the sterilisation environment 3 (or the permanence time therein, in the case of a static batch-like operation).
- a controlled flow of hydrogen peroxide aqueous solution is suctioned from source 4 into the mixing device 6 by the driving action of a controlled carrier flow of sterile air supplied from source 5.
- the resulting dispersion of atomised hydrogen peroxide is heated in evaporator 7 , hydrogen peroxide being thereby vaporised.
- the resulting VHP gaseous, dispersion is fed to the sterilising environment 3 to serve as the sterilising agent.
- Sensing means 8 detects VHP concentration upstream from the sterilisation environment 3.
- a first check is carried out to ensure that the gaseous dispersion fed -into the sterilisation environment 3 does have the expected VHP concentration and is therefore capable of exerting on items 2 the necessary sterilising action.
- the control unit may act, in response to the output signal of sensor 8, on either the mass flow rate of hydrogen peroxide aqueous solution or the sterile air flow rate with a view to adjusting the VHP concentration value upstream from the sterilisation environment.
- a decrease in the titre of the hydrogen peroxide aqueous solution due e.g.
- sensor 8 detects a VHP concentration lower than an alarm threshold value, an alarm signal is submitted to the control unit which, in response to this signal, proceeds to interrupt the feed of items 2 to be sterilised to the sterilisation environment 3, at least until conditions for effective sterilisation in the sterilisation environment 3 are restored.
- sensors 8' and 8'' detect VHP concentration at least at two distinct positions within the sterilisation environment.
- a second ' check is carried out to ensure that at least a minimum VHP concentration is maintained in the sterilisation environment 3. This may be of particular relevance when the sterilisation environment 3 is large and not hermetically sealed, and even more so if the sterilisation environment 3 is maintained below atmospheric pressure, since the local VHP concentration may differ from the VHP concentration detected upstream by sensor 8, e.g. due to accidental infiltrations or contaminations.
- a third check is carried out, based on the differential information obtained from the elaboration of the output signals of sensors 8', 8'', to ensure that VHP consumption along the sterilisation path, i.e. as sterilisation progresses, is greater than a threshold value corresponding to a sufficient exposure to the sterilising agent.
- this third check it may be ensured that all items advancing through the sterilisation environment 3 are exposed to enough sterilising agent and for long enough to achieve the intended sterilised condition.
- control unit may act, in response to the output signals of sensors 8' and 8'', on either the mass flow rate of hydrogen peroxide aqueous solution or the sterile air flow rate with a view to adjusting the VHP concentration value upstream from the sterilisation environment.
- an insufficient VHP concentration within the sterilisation environment 3 may be compensated by supplying more hydrogen peroxide.
- control unit may act, in response to the output signals of sensors 8' and 8' ', on the speed at which items 2 are fed into the sterilisation environment 3 or on the permanence time of items 2 within sterilisation environment 3, when batch-like operated.
- the sterilisation and disinfection apparatus of the invention enables accurately controlled and effective sterilisation whilst reducing manufacturing and management costs, since the use of excess hydrogen peroxide is significantly limited and the semiconductor oxide sensors are commercially available at prices remarkably lower than other more sophisticated sensors for detecting hydrogen peroxide. Furthermore, real-time monitoring of VHP concentration at different locations along the sterilisation path enables precise control of operating conditions and, consequently, very high standards of hygiene and safety for the sterilised items.
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009801628602A CN102802678A (zh) | 2009-12-10 | 2009-12-10 | 杀菌消毒装置 |
US13/514,149 US20130028794A1 (en) | 2009-12-10 | 2009-12-10 | Sterilising and disinfection apparatus |
EP09802034A EP2509641A1 (fr) | 2009-12-10 | 2009-12-10 | Appareil de stérilisation et de désinfection |
PCT/IT2009/000558 WO2011070600A1 (fr) | 2009-12-10 | 2009-12-10 | Appareil de stérilisation et de désinfection |
JP2012542689A JP2013513420A (ja) | 2009-12-10 | 2009-12-10 | 滅菌および消毒装置 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IT2009/000558 WO2011070600A1 (fr) | 2009-12-10 | 2009-12-10 | Appareil de stérilisation et de désinfection |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011070600A1 true WO2011070600A1 (fr) | 2011-06-16 |
Family
ID=42066471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IT2009/000558 WO2011070600A1 (fr) | 2009-12-10 | 2009-12-10 | Appareil de stérilisation et de désinfection |
Country Status (5)
Country | Link |
---|---|
US (1) | US20130028794A1 (fr) |
EP (1) | EP2509641A1 (fr) |
JP (1) | JP2013513420A (fr) |
CN (1) | CN102802678A (fr) |
WO (1) | WO2011070600A1 (fr) |
Cited By (1)
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CN103662198A (zh) * | 2013-11-12 | 2014-03-26 | 苏州苏东庭生物科技有限公司 | 酒瓶消毒箱 |
JP6439920B2 (ja) * | 2013-11-14 | 2018-12-19 | 大日本印刷株式会社 | ボトルの殺菌方法及び装置 |
JP6473057B2 (ja) * | 2015-07-23 | 2019-02-20 | 三菱重工機械システム株式会社 | 殺菌剤の気化方法及び気化装置 |
CN106075516A (zh) * | 2016-07-26 | 2016-11-09 | 张剑 | 一种压力蒸汽灭菌过程验证装置及其灭菌效果监测方法 |
DE102016125027A1 (de) * | 2016-12-20 | 2018-06-21 | Krones Ag | Vorrichtung zum Behandeln von Anlagenkomponenten und/oder Packmitteln mit verdampftem Wasserstoffperoxid |
CA3056223A1 (fr) | 2017-03-27 | 2018-10-04 | Regeneron Pharmaceuticals, Inc. | Methodes de sterilisation de produits medicaux et produits medicaux sterilises |
CN108686241B (zh) * | 2017-04-10 | 2021-03-26 | 山东新华医疗器械股份有限公司 | 灭菌方法和灭菌装置 |
JP7228950B2 (ja) * | 2017-06-05 | 2023-02-27 | 四国化工機株式会社 | 容器の殺菌方法 |
CN109550180A (zh) * | 2018-12-07 | 2019-04-02 | 北京欣迪康泰科技有限公司 | 一种消除封闭环境中g类化学毒剂的方法 |
IT202000003883A1 (it) * | 2020-02-25 | 2021-08-25 | Comecer Spa | Metodo e impianto per decontaminare in continuo contenitori rigidi |
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2009
- 2009-12-10 US US13/514,149 patent/US20130028794A1/en not_active Abandoned
- 2009-12-10 JP JP2012542689A patent/JP2013513420A/ja active Pending
- 2009-12-10 WO PCT/IT2009/000558 patent/WO2011070600A1/fr active Application Filing
- 2009-12-10 CN CN2009801628602A patent/CN102802678A/zh active Pending
- 2009-12-10 EP EP09802034A patent/EP2509641A1/fr not_active Withdrawn
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GB2191585A (en) * | 1986-06-09 | 1987-12-16 | American Sterilizer Co | Sensor indicating and controlling substance concentration |
WO1998000176A1 (fr) * | 1996-07-03 | 1998-01-08 | American Sterilizer Company | Controle de regulation de procedes de sterilisation avec des modules de detection semi-conducteurs |
GB2331810A (en) * | 1997-11-28 | 1999-06-02 | Taiyo Toyo Sanso Co Ltd | Temperature and humidity compensation for a semiconductor gas sensor |
US20040262170A1 (en) * | 2003-06-27 | 2004-12-30 | Steris Inc. | Sensor for sensing a chemical component concentration using an electroactive material |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110191870A (zh) * | 2017-01-11 | 2019-08-30 | 通用电气公司 | 使用SiGa和/或Siln合金的熔渗法 |
Also Published As
Publication number | Publication date |
---|---|
EP2509641A1 (fr) | 2012-10-17 |
JP2013513420A (ja) | 2013-04-22 |
CN102802678A (zh) | 2012-11-28 |
US20130028794A1 (en) | 2013-01-31 |
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