WO2011021846A3 - 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법 - Google Patents

다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법 Download PDF

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WO2011021846A3
WO2011021846A3 PCT/KR2010/005452 KR2010005452W WO2011021846A3 WO 2011021846 A3 WO2011021846 A3 WO 2011021846A3 KR 2010005452 W KR2010005452 W KR 2010005452W WO 2011021846 A3 WO2011021846 A3 WO 2011021846A3
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nucleic acid
acid chip
nanostructure arrays
deposited nucleic
diagnosing
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PCT/KR2010/005452
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WO2011021846A2 (ko
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이상엽
유소영
김도균
박태정
윤정국
이진
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한국과학기술원
(주)아벨리노
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Priority to EP10810154.4A priority Critical patent/EP2468884B1/en
Priority to JP2012525483A priority patent/JP5453534B2/ja
Priority to CN2010800471813A priority patent/CN102648291A/zh
Priority to US13/391,167 priority patent/US9145583B2/en
Publication of WO2011021846A2 publication Critical patent/WO2011021846A2/ko
Publication of WO2011021846A3 publication Critical patent/WO2011021846A3/ko

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Abstract

본 발명은 다중 스팟(multi-spot) 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩에 관한 것으로, 보다 상세하게는 국소 표면 플라즈몬 공명(localized surface plasmon resonance; LSPR) 광학특성을 이용할 수 있는 다중 스팟 금속 증착형 나노구조배열 핵산칩 및 이의 제조방법과 여러 종류의 각막이상증을 진단할 수 있는 BIGH3 유전자 돌연변이 진단용 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩에 관한 것이다.본 발명에 따르면, 금속 증착형 나노구조배열 핵산칩과 광원, 검출기, 분광광도계 및 컴퓨터를 포함하는 분석장치를 결합함으로서 LSPR 광학특성 기반 비표지 광학 바이오센서로서 응용이 가능할 뿐만 아니라, 본 발명에 따른 BIGH3 유전자 돌연변이 진단용 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩을 이용하면 유전적 안과질환인 여러 종류의 각막이상증을 한 번에 진단할 수 있다.
PCT/KR2010/005452 2009-08-18 2010-08-18 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법 WO2011021846A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP10810154.4A EP2468884B1 (en) 2009-08-18 2010-08-18 Multi-spot metal-deposited nucleic acid chip with nanostructure arrays for diagnosing corneal dystrophy
JP2012525483A JP5453534B2 (ja) 2009-08-18 2010-08-18 多重スポット金属蒸着型ナノ構造配列角膜ジストロフィー診断用核酸チップ及びこの製造方法
CN2010800471813A CN102648291A (zh) 2009-08-18 2010-08-18 用于诊断角膜营养不良的多点金属封端的纳米结构阵列核酸芯片及其制备方法
US13/391,167 US9145583B2 (en) 2009-08-18 2010-08-18 Multi-spot metal-capped nanostructure array nucleic acid chip for diagnosis of corneal dystrophy and preparation method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090076300A KR101041606B1 (ko) 2009-08-18 2009-08-18 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법
KR10-2009-0076300 2009-08-18

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WO2011021846A2 WO2011021846A2 (ko) 2011-02-24
WO2011021846A3 true WO2011021846A3 (ko) 2011-06-23

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US (1) US9145583B2 (ko)
EP (1) EP2468884B1 (ko)
JP (2) JP5453534B2 (ko)
KR (1) KR101041606B1 (ko)
CN (1) CN102648291A (ko)
WO (1) WO2011021846A2 (ko)

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