WO2011019210A9 - Supplément diététique, composition alimentaire et pharmaceutique contenant de la graine de chia et du maca, procédé de préparation correspondant - Google Patents

Supplément diététique, composition alimentaire et pharmaceutique contenant de la graine de chia et du maca, procédé de préparation correspondant Download PDF

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WO2011019210A9
WO2011019210A9 PCT/KR2010/005278 KR2010005278W WO2011019210A9 WO 2011019210 A9 WO2011019210 A9 WO 2011019210A9 KR 2010005278 W KR2010005278 W KR 2010005278W WO 2011019210 A9 WO2011019210 A9 WO 2011019210A9
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maca
group
weight
feed
chia seeds
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PCT/KR2010/005278
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English (en)
Korean (ko)
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WO2011019210A3 (fr
WO2011019210A2 (fr
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김연진
김호준
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Kim Younjin
Kim Hojun
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Priority to US13/390,064 priority Critical patent/US20120141601A1/en
Priority to JP2012524642A priority patent/JP2013501778A/ja
Priority to CN2010800458838A priority patent/CN102573523A/zh
Priority claimed from KR1020100077099A external-priority patent/KR101320374B1/ko
Publication of WO2011019210A2 publication Critical patent/WO2011019210A2/fr
Publication of WO2011019210A3 publication Critical patent/WO2011019210A3/fr
Publication of WO2011019210A9 publication Critical patent/WO2011019210A9/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Definitions

  • the present invention relates to a dietary supplement, a food additive, a feed, a feed additive, a pharmaceutical composition, and a method for manufacturing the same, including a chia seed and maca, wherein the dietary supplement includes weight loss, sexual function, It has significant effects on improving intestinal or liver function, increasing male hormone secretion and improving endurance.
  • the general high-fat diet of modern man increases the content of cholesterol in the living body, thereby causing the whole body abnormalities due to cardiovascular disorders and liver dysfunction, and has been a representative cause of sexual dysfunction with stress.
  • This high-fat diet is not only the sexual dysfunction, but also leads to a decline in endurance in daily life.
  • Papaverine is an opiate alkaloid that relaxes smooth muscles of the ureters and blood vessels
  • phentolamine is an adrenergic inhibitor.
  • Trazotone, yohimbine, and the like are known as oral drugs, but their pharmacological mechanisms are unclear.
  • Citrulline is also known to stimulate blood production by stimulating the production of nitric oxide (NO) to dilate blood vessels.
  • ginseng including red ginseng has hydroxy radical scavenging ability and strong antioxidant power, and has been reported to be used to improve sexual function and improve erectile ability, and thus, research on these substances is being actively conducted. . Although a series of studies are underway, it is still a long way to expect Viagra effects on natural materials. In addition, patients are suffering from diseases as well as the burden of medical expenses. Therefore, there is an urgent need for the development of sexual dysfunction and endurance-improving substances that can be utilized in the clinical field.
  • Examples of patent applications on improving sexual function and enhancing endurance include functional eggs obtained by feeding ginseng cultured roots from Korea Institute of Oriental Medicine, and endurance enhancement in the eggs (Korean Patent Application 2005-0115891), endurance by red ginseng and thorny ginseng microcoxin Improvement (Korean Patent Application No. 1997-0024211), Endurance Enhancement Effect by Glutamine Peptide and Chlorella Growth Factor (Korea Patent Application 1998-0040319), Endurance Enhancement / Improvement by Propolis Extract Powder ( Korean Patent No. 10-0329010), the endurance enhancement effect by octacosanol (Korean Patent 10-0329011) and the like.
  • the present invention has been made on the basis of the fact that the mixed composition of chia seeds and maca enhances the health of the human body and livestock in various aspects, and it is a dietary supplement comprising chia seeds and maca as a main ingredient or Its purpose is to provide food additives.
  • Another object of the present invention is to provide a feed or a feed additive comprising the chia seeds and maca as main ingredients.
  • It is another object of the present invention to provide a pharmaceutical composition comprising the chia seeds and maca as main ingredients.
  • Health supplements, food additives, feed or feed additives of the present invention is characterized in that it comprises 100 parts by weight of chia seeds and 5 to 250 parts by weight of maca to achieve the above object.
  • the chia seeds and maca may each be used by themselves, or may be powdered or extracted, for example, an extract extracted with a solvent selected from the group consisting of water, ethanol, and mixtures thereof.
  • the dietary supplement, food additives, feed or feed additives may further include a mineral selected from the group consisting of germanium, selenium, dietary zinc and mixtures thereof.
  • the content of the mineral is preferably 0.1 to 10 parts by weight per 100 parts by weight of chia seeds.
  • the mineral is not necessarily limited thereto, but is preferably an extract extracted with a solvent selected from the group consisting of water, lower alcohol, ethyl acetate, aromatic hydrocarbons, chlorinated hydrocarbons, and mixtures thereof.
  • the food additive or feed additive is preferably contained in 0.001 to 5% by weight, more preferably 0.5 to 2.5% by weight in the food or feed. Do.
  • the pharmaceutical composition of the present invention for improving sexual function, intestinal function or liver function containing 100 parts by weight of chia seeds and 5 to 250 parts by weight of maca extracted with a solvent selected from the group consisting of water, ethanol and mixtures thereof as an active ingredient. It may be a pharmaceutical composition.
  • the content of the extract contained as an active ingredient may be appropriately determined according to the sex, age, degree of disease, specific type of disease, etc. of the patient, for example, 0.001 to 80% by weight, based on the total weight of the pharmaceutical composition, preferably Preferably 0.01 to 50% by weight.
  • the method for preparing the health supplement, food additive, feed, feed additive, or pharmaceutical composition of the present invention is not particularly limited, but may be prepared by, for example, a method comprising the following steps:
  • the manufacturing method may further comprise the step of (D) grinding the tooth seed and maca to an average particle size of 0.3 to 2 ⁇ m before step (A).
  • the pharmaceutical composition may further include one or more additives selected from the group consisting of pharmaceutically acceptable excipients, adjuvants, diluents, isotonic agents, preservatives, lubricants, and dissolution aids.
  • the pharmaceutical composition is Viagra, Vebita, Cialis, heavy drug, Zydena, green tea, nucleic acid-containing complex, bioactive substance derived from algae, oyster mushroom juice, Zipacic acid extract, microcoxin and mixtures thereof It may further comprise a selected component.
  • the pharmaceutical composition may be a pharmaceutical composition for skin cell activation in addition to improving sexual function, intestinal function or liver function.
  • the pharmaceutical composition may be a pharmaceutical composition for removing the hangover.
  • the pharmaceutical composition may be a pharmaceutical composition for nicotine removal.
  • the pharmaceutical composition may be a pharmaceutical composition for removing bad breath and body odor.
  • the pharmaceutical composition may be a pharmaceutical composition for treating erectile dysfunction.
  • the pharmaceutical composition may be a pharmaceutical composition for improving infertility.
  • the pharmaceutical composition may be a pharmaceutical composition for weight loss.
  • the pharmaceutical composition may be a pharmaceutical composition for fatigue recovery.
  • the pharmaceutical composition may be a pharmaceutical composition for improving endurance.
  • the pharmaceutical composition may be a pharmaceutical composition for improving blood circulation.
  • the pharmaceutical composition may be a pharmaceutical composition for reducing cholesterol.
  • the pharmaceutical composition may be a pharmaceutical composition for increasing immunity.
  • the pharmaceutical composition may be a pharmaceutical composition for enhancing sex hormone.
  • the dietary supplement or food additive may be a dietary supplement or food additive for improving intestinal function, sexual function or liver function.
  • the dietary supplement or food additives may be a tonic, tonic, or fertility supplement or food additive.
  • the feed or feed additive may be a feed or feed additive for improving intestinal function, sexual function or liver function.
  • the feed or feed additives for weight loss, fatigue recovery, endurance, blood circulation improvement, cholesterol reduction, inflammation reduction, immunity enhancement, sex hormone increase, skin care, bad breath removal, body odor removal, tonic, or fertility improvement feed Or a feed additive.
  • the tooth seed constituting the dietary supplement of the present invention is rich in dietary fiber, omega-3 fatty acids, including vegetable fats, amino acids, and minerals, and has no cholesterol, so it is excellent in physical strength, health and beauty, and diet. Although it is a food having an effect, there is a problem in that side effects such as diarrhea and increased fatigue and diarrhea caused by weight loss during long-term administration.
  • the present inventors confirmed that by adding and mixing the maca to the chia seeds, not only solve the above problems while maintaining the efficacy of the chia seeds, but also can exhibit additional efficacy.
  • the health supplement, food additive, feed, feed additive, or pharmaceutical composition of the present invention contains chia seeds, maca, powders or extracts thereof derived from plants as a main ingredient, and germanium, selenium, or dietary zinc, if necessary. It can be added in addition to the biological and biochemical aspects of weight loss, fatigue recovery, endurance improvement, blood circulation, cholesterol reduction, inflammation reduction, immunity increase, sex hormone increase, skin care, hangover removal, nicotine removal, bad breath removal It is effective in preventing and improving intestinal, sexual or hepatic dysfunction, such as body deodorization, tonic, or infertility improvement.
  • 1 is a graph showing the weight change by administration of chia seeds and maca.
  • FIG. 2 is a graph showing the effect of the administration of chia seeds and maca on blood pressure.
  • Figure 3 is a graph showing the effect on the endurance of the administration of chia seeds and maca through swimming analysis.
  • Figure 4 is a graph showing the effect of the administration of the tooth seed and maca on the amount of exercise through the field test.
  • Figure 5 is a photograph of the effect of the administration of chia seeds and maca on the movement path of the rat in the field test.
  • Figure 6 is a graph showing the effect of the administration of the tooth seed and maca on spatial perception in the rotarod test.
  • FIG. 7 is a graph showing the change in blood alcohol concentration by administration of chia seeds and maca.
  • 9 is a graph showing the activity of aldehyde dehydrogenase by administration of chia seeds and maca.
  • 10 is a graph showing the whole blood testosterone amount by administration of chia seeds and maca.
  • 11 is a graph showing the amount of testosterone in the tail vein by administration of chia seeds and maca.
  • FIG. 12 is a graph showing the whole blood high density lipoprotein amount by administration of chia seeds and maca.
  • the present inventors have conducted a long study on natural preparations having an effect of improving elderly diseases such as degeneration of the nervous system, endocrine system and cardiovascular disease from various adult diseases such as liver disease, motor dysfunction and renal dysfunction.
  • elderly diseases such as degeneration of the nervous system, endocrine system and cardiovascular disease from various adult diseases such as liver disease, motor dysfunction and renal dysfunction.
  • plant-derived chia seeds and maca, their powders or extracts inhibit weight loss, improve sexual function, increase male hormone secretion, increase endurance, and inhibit liver dysfunction in biochemical, cellular and animal behavioral experiments
  • the present invention was completed by finding out.
  • Chia seed is a seed of Salvia hispanica or Salvia columbariae , and has been used as a traditional food for improving durability, fitness, health and beauty in South America such as Mexico for over 1000 years. Such chia seeds have traditionally been consumed in Mexico, the southeastern United States and South America, but are not widely known in Asia or Europe.
  • Chia seed is gelatinized when added to water, and the volume expands 10 times, and because it expands in the body's digestive juices, it is used as a diet food because it has a effect of maintaining satiety by ingestion. It also reduces the absorption of fat into the body, which further aids in weight loss.
  • the tooth seed contains 28% dietary fiber, which is overwhelmingly higher than lettuce, spinach and agar. Dietary fiber is not digested in the human body, but from the stomach to the small and large intestine, the physical and chemical properties such as water retention, cation exchange, gel formation, adsorption, etc. affects the digestive absorption of other nutrients. If the amount of dietary fiber in the food is excessive, the food may pass too quickly through the digestive tract and digestion and absorption does not occur sufficiently, which may cause weight loss. In addition, due to the excretion in combination with water may be symptoms such as diarrhea or dehydration.
  • chia seeds are about 32% vegetable fat, of which more than 60% is made of linolenic acid, such as omega-3 fatty acids. This omega-3 fatty acid content is much higher than that of other sources of omega-3 fatty acids, fish and flax.
  • Chia Seed is a natural health food that contains abundant 18 amino acids such as glutamine, arginine, asparagine, leucine, valine, and alanine, and is free of cholesterol. Furthermore, it contains abundant mineral components such as calcium, phosphorus, magnesium, potassium, iron, zinc and copper, and also contains natural antioxidants.
  • polysaccharide corresponding to the dietary fiber in the chia seeds is a mixture of polysaccharides having an average molecular weight of 74674, 21722, 8066, 2038, 1050, respectively.
  • These low- and medium-molecular weight mixtures are also composed of porous fibrous shells, which can hold 5 to 40 times as much water, thus leaving them in a gel state for 2 to 30 minutes. Included.
  • chia seed is a food having such excellent efficacy as described above, side effects such as lethargy and increased fatigue due to weight loss may occur when taking longer term for several weeks. Furthermore, about 10% of the dosers have a problem of showing side effects such as diarrhea as mentioned above.
  • the inventors of the present invention while testing the combination with various ingredients to solve the above problems while maintaining the efficacy of the chia seeds, it was confirmed that there are no side effects when mixed with maca, and also can exhibit additional efficacy It was completed.
  • Maca which forms an essential component of the present invention together with the chia seeds, is a herbal medicine for nourishing tonic and fatigue recovery, and its official name is Lepidium meyenii Walp. Wild maca resembles a rose in flower shape, and dried roots and kernels are edible. It is a plant that grows in the harsh climate of high altitudes of more than 4000 meters above sea level since the Inca era, which civilized in the Andes Mountains of South America. Maca is a nutritious and precious food that grows in the natural environment where it is difficult to grow plants, such as intense sunshine during the day, temperatures below freezing at night, low air pressure and strong winds. Maca roots look like potatoes, and kernels also look like potatoes. A thin stem extends from the kernel to one stem.
  • Maca also known as ginseng of the Andes, is known to enhance sexual function, represented by energy.
  • the amino acids lysine and arginine contained in maca activate the reproductive organs to prevent the cause of infertility, such as abnormal ovaries, and to correct the hormone system in women is reported to be effective in menstrual pain or menstrual disorders. Furthermore, it improves menopausal symptoms caused by a rapid hormonal decline in postmenopausal women.
  • Maca also contains large amounts of 'alkaloids' that are effective in stress erectile dysfunction. It also contains 'steroids' related to male hormones that promote the increase of egg and sperm, and 'dextrins' that activate blood flow in the penile arteries.It also contains other active substances such as anthocyanins, saponins, and terpenoids. It contains. These ingredients naturally improve erectile dysfunction in men. Furthermore, Viagra In contrast to the chemical erectile dysfunction represented by the serious side effects, maca has the same effect but is a natural plant has the advantage of no side effects.
  • KFDA's foods are effective in regulating female sex hormones, improving fertility, improving energy, maintaining immune system, improving anemia, chronic fatigue syndrome, lethargy and menopausal syndrome, as well as menstrual cramps. It is listed in the raw materials.
  • Each of the above components may be ingested by itself or may be ingested by powdering, or may be separately extracted to obtain an extract, and these extracts may be mixed, or may be first mixed and then extracted and used together. Alternatively, the necessary herbal ingredients can be added, mixed and extracted together.
  • Example 2 The same procedure as in Example 1 was carried out, 5 g of chia seeds and 10 g of maca were used, and were obtained as an extract filtrate without undergoing a lyophilization step.
  • the weight of the normal group without the ingestion of alcohol and extracts was 380.5 ⁇ 13.3 g after 5 weeks, 350.2 ⁇ 11.2 g for the control group with no alcohol but no extract, and 340.2 ⁇ 5.2 g for the group receiving the alcohol and chia seed extract. , 317.1 ⁇ 3.1 g of the group receiving the alcohol and maca extract, and 315.1 ⁇ 7.2 g of the group receiving the mixed extract of alcohol, chia seed and maca. Therefore, it was confirmed that the body weight was decreased by 11 to 18% in the group administered with the mixed extract of chia seeds and / or maca (FIG. 1).
  • Spragus-Dawley male rats did not consume alcohol and extracts
  • the control group was ingested with alcohol but not with extracts
  • 1 wt% octacosanol group 1 wt% chia seed group
  • 0.5 6% of each group was administered for 26 days, divided into groups administered with the wt% maca, 1% by weight of the chia seeds and 0.5% by weight of maca.
  • Feed was administered only normal feed other than drinking water in the normal group, only 25% alcohol and normal feed in the control group, the rest was administered according to the above-described content.
  • the control group is 306.33 ⁇ 6.21 seconds, 147.16 ⁇ 21.71 seconds tended to decrease to about 46% of the normal group.
  • the octacosanol group was 352.66 ⁇ 34.69 seconds
  • the chia seed group was 355.66 ⁇ 34.62 seconds
  • the maca group was 476.00 ⁇ 45.56 seconds
  • the chia seed and maca group was 527.83 ⁇ 25.57 seconds. Endurance tended to increase by 3.2 times and 3.5 times.
  • the momentum of the normal group is 1179.2 ⁇ 21.2 cm
  • the control group showed a 30 ⁇ 21.2 cm tendency to decrease by about 75% than the normal group.
  • the normal group was actively moved over the entire plane, but the control group mainly moved to the center.
  • the octacosanol group was 240.2 ⁇ 12.3 cm
  • the chia seed group was 510.1 ⁇ 21.3 cm
  • the maca group was 718 ⁇ 11.3 cm
  • the chia seed and maca group was 891 ⁇ 17 cm, respectively. 8 times, 17 times, 24 times, 30 times more exercise. From this field test, it can be determined that octacosanol, chia seeds, maca and mixtures of chia seeds and maca increase the momentum, and among them, the mixture of chia seeds and maca most significantly increases the momentum (FIG. 4, FIG. 4). 5).
  • the octacosanol-administered group was 98.16 ⁇ 11.35 sec
  • the chia seed-administered group was 151.50 ⁇ 5.08 sec
  • the maca-administered group was 215.33 ⁇ 13.14 sec
  • the chia seed and maca co-administered group was 240.66 ⁇ 39.30 sec. 5 times, 5 times, 7 times, and 8 times more space perception and endurance. From these spatial perception tests, octacosanol, chia seeds, maca and mixtures of chia seeds and maca increase spatial perception and endurance, and it can be judged that the mixture of chia seeds and maca has the greatest effect (Fig. 6, Table 2).
  • the blood alcohol concentration was measured from the extract obtained according to the method of the present invention.
  • the octacosanol group was 0.034%
  • the chia seed group was 0.024%
  • the maca group was 0.019%
  • the chia seed and maca group was 0.016%. This is because the alcohol level is reduced by 55%, 60%, 69%, 74%, respectively, compared to the control group, and this result is believed to be because it strongly promotes detoxification by activating the alcohol decomposing function of the liver (FIG. 7).
  • alcohol dehydrogenase When alcohol enters the body, it is converted to acetaldehyde, a toxic substance by alcohol dehydrogenase, a primary enzyme, which is in turn toxic to aldehyde dehydrogenase, a secondary enzyme, aldehyde dehydrogenase. Is switched to.
  • the test group of Experimental Example 3 was anesthetized with chloroform and the abdomen was cut to take liver.
  • the liver tissue was placed in a 10-fold volume of 100 mM sodium phosphate buffer (pH 7.4), homogenized with a homogenizer and destroyed again with an ultrasonic grinder.
  • Nuclear and cell debris were removed by centrifugation at 700 G for 10 minutes, and alcohol dehydrogenase and aldehyde dehydrogenase activities in hepatocytes were measured using the supernatant obtained by centrifugation at 9000 G for 20 minutes.
  • the protein concentration of the supernatant was measured by BCA kit to correct the deviation of liver tissue volume between the experimental groups.
  • the activity of alcohol dehydrogenase was 5 min by adding 10 ⁇ l of liver tissue homogenate to 50 mM sodium phosphate buffer (pH 7.4) containing 1 mM NAD + , 5 ⁇ M rotenone (NADPH oxidase inhibitor of mitochondria), 5 mM ethanol. Liver culture was obtained by measuring absorbance at 340 nm. The activity of the aldehyde dehydrogenase is 1 mM NAD + , 5 ⁇ M rotenone, 0.1 mM pyrazole (pyrazole.
  • ALD inhibitor 5 mM propanal, 2 mM 2-mercaptoethanol (2-mercaptoethanol) 10 ⁇ l of liver tissue homogenate was added to 50 mM sodium phosphate buffer (pH 7.4) for 5 minutes, and absorbance was measured at 340 nm.
  • the normal group was 13.8 ⁇ 1.4 mmomle / min / mg protein, 4.7 ⁇ 0.7 mmomle / min / mg protein in control group, 8.9 ⁇ 0.8 mmomle / min / mg protein in octacosanol group, 16 ⁇ 1.2 mmomle / min / mg protein in chia seed group, 14.5 ⁇ 1.0 mmomle / min / mg group in maca group Protein and chia seed and maca co-administrative group were 19 ⁇ 1.2 mmomle / min / mg protein, which showed the greatest increase in alcohol dehydrogenase activity.
  • the reason why the activity of alcohol dehydrogenase was increased in the administration group of chia seeds and the like was considered to be that
  • Testosterone was measured by enzyme-immunoassay (EIA: Roche, USA) through partial blood in the tail vein 25 days after drinking 25% alcohol daily for 25 days in the test group of Experimental Example 3 To measure the concentrations of whole blood testosterone and high-density lipoprotein, it was referred to the Dual Medical Foundation.
  • the total blood testosterone amount was measured from the extract of the present invention, and the normal group was 473.0 ⁇ 223.0 ng / dL, and the control group was 115.1 ⁇ 54.1.
  • the amount of testosterone was shown to be the largest increase (FIG. 10).
  • the reason why the amount of testosterone in the administration group such as chia seed is increased compared to the control group is considered to be that the chia seed and maca components stimulate the testosterone secretion of the testis. As the amount of testosterone is increased it can be seen that the sexual function of these administration groups is improved.
  • Figure 11 shows the amount of testosterone measured in the tail vein shows a similar tendency to whole blood testosterone in the heart.
  • the amount of high-density lipoprotein was measured from the extract of the present invention, and the normal group was 44.7 ⁇ 4.0 mg / dL, and the control group was 29.1. ⁇ 3.8 mg / dL, 32.5 ⁇ 1.5 mg / dL for the octacosanol group, 41.0 ⁇ 4.1 mg / dL for the chia seed group, 44.1 ⁇ 3.6 mg / dL for the maca group, and 45.2 ⁇ 0.6 mg / d for the simultaneous seed and maca group dL.
  • Example 8 For the clinical test, 20 male smokers in their 30s who had problems with sexual function, bowel function, liver function, and the like, were given the composition obtained in Example 8 two to three times a day for one month.
  • composition of the present invention comprising chia seeds and maca (extract) can be usefully used as a pharmaceutical composition as well as dietary supplements or feeds.
  • the amount of use may vary depending on the sex, age, degree of disease, etc. of the patient, but when the chia seeds and maca included therein are used as herbal medicines without being extracted with water or an organic solvent.
  • the amount of 1.0 g to 50 g per day can be used, when used in the form of extract can be administered once to several times 10 mg to 1000 mg per day. However, it is not necessarily limited thereto.
  • the pharmaceutical composition of the present invention is a conventional Viagra that is already effective in treating reproductive metabolic diseases such as improving sexual function, enhancing endurance, and liver dysfunction.
  • Bebitra Cialis , Heavy-drug , Zydena It may be used in combination with the same, and may also be used in combination with a component selected from the group consisting of green tea, a nucleic acid-containing complex, a bioactive substance derived from algae, oyster mushroom juice, zipaic acid extract, microcoxin and mixtures thereof.
  • Viagra has been reported side effects such as increasing the corpus cavernosum smooth muscle NO (nitric oxide) or raising blood pressure, using the pharmaceutical composition of the present invention in combination with the conventional drug can reduce the amount of the existing drug and therefore It can alleviate problems with drugs.
  • the pharmaceutical composition of the present invention may be prepared by mixing with excipients, adjuvants, analgesics, isotonic agents, preservatives, etc., which are commonly used in the pharmaceutical, and formulated in the form of a pharmaceutically acceptable formulation.
  • Such pharmaceutical preparations include injections, solutions, tablets, capsules, powders, syrups and the like.
  • Example 1 50 mg of the chia seed and maca extract of Example 1 were dissolved in distilled water for injection, adjusted to pH of about 7.6 with 0.1 N sodium hydroxide, the whole was made into 2 ml, and then filled into 2 ml ampoules and sterilized. To prepare acupuncture injections.
  • Example 2 50 mg of the chia seed and maca extract of Example 2 were dissolved in distilled water for injection, adjusted to pH 7.2 with 0.1 N sodium hydroxide, the whole was made up to 2 ml and then filled into 2 ml ampoules and sterilized. To prepare acupuncture injections.
  • Tablets were prepared by mixing 200 mg of chia seeds and maca extract of Example 1, 100 mg of lactose, 100 mg of starch, and magnesium stearate, and tableting according to a conventional tablet preparation method.
  • Tablets were prepared by mixing 10 mg of chia seeds and maca extract of Example 1, 100 mg of lactose, 50 mg of starch, and magnesium stearate, and tableting according to a conventional tablet preparation method.
  • a powder was prepared by mixing 1000 mg of chia seeds and maca extract of Example 5, 100 mg of lactose, and 2 mg of magnesium stearate, and filling and sealing the inside with a polyethylene chloride-coated paper cloth.
  • Capsules were prepared by mixing 400 mg of chia seeds and maca extract of Example 1, 100 mg of lactose, 93 mg of starch, 2 mg of talc, and magnesium stearate, and filling gelatin capsules according to a conventional capsule preparation method.
  • chia seeds and maca extract of Example 1 500 mg of chia seeds and maca extract of Example 1, 50 mg of alendronate (alendronate sodium), 100 mg of lactose, 50 mg of starch, 2 mg of talc and magnesium stearate are mixed and added to the gelatin capsule according to a conventional capsule preparation method.
  • the capsule was prepared by filling.
  • Chia Seed and Maca Extract of Example 1 500 mg, ARICEPT ) 20 mg, lactose 100 mg, starch 50 mg, talc 2 mg and magnesium stearate were mixed and filled into gelatin capsules according to a conventional capsule preparation method to prepare a capsule.
  • chia seed and maca extract of Example 1 500 mg of chia seed and maca extract of Example 1, 10 mg of raloxifene, lactose 50 mg, starch 50 mg, talc 2 mg and magnesium stearate are mixed and filled into gelatin capsules according to a conventional capsule preparation method. To prepare a capsule.
  • 500 mg of the chia seed and maca extract of Example 1 1000 mg of pamidronate disodium, 20 g of sugar, 20 g of isomerized sugar and a suitable amount of lemon flavor were added to purified water to make 100 ml in total, and a conventional liquid formulation. After mixing according to the preparation method, 100 ml of brown bottle was filled and sterilized to prepare a liquid.

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  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

La présente invention concerne un supplément diététique, un additif alimentaire, un aliment pour animaux, un additif pour alimentation animale et une composition pharmaceutique contenant de la graine de chia et du maca, ainsi qu'un procédé de préparation correspondant. Le supplément diététique et analogues selon la présente invention contient de la graine de chia et du maca dérivé d'une plante, et une poudre ou un extrait de celui-ci en tant que principaux ingrédients, et peut également, le cas échéant, contenir du germanium, du sélénium ou du zinc diététique, et présente des effets remarquables de prévention et d'amélioration de troubles de la fonction intestinale, de la fonction sexuelle ou de la fonction hépatique, tels que la réduction de poids, l'atténuation de fatigue, l'accroissement d'endurance, l'amélioration de la circulation sanguine, la réduction de cholestérol, la réduction d'inflammation, l'activation d'immunité, l'accroissement des hormones sexuelles, les soins de la peau, le soulagement de la gueule de bois, l'élimination de la nicotine, l'élimination de mauvaise haleine, l'élimination d'odeurs corporelles, le traitement de l'effet analeptique ou de la stérilité en termes biologiques ou biochimiques.
PCT/KR2010/005278 2009-08-11 2010-08-11 Supplément diététique, composition alimentaire et pharmaceutique contenant de la graine de chia et du maca, procédé de préparation correspondant WO2011019210A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/390,064 US20120141601A1 (en) 2009-08-11 2010-08-11 Dietary supplement, feed and pharmaceutical composition containing chia seed and maca, and preparation method thereof
JP2012524642A JP2013501778A (ja) 2009-08-11 2010-08-11 チアシード及びマカを含む健康補助食品、飼料、薬学組成物並びにその製造方法
CN2010800458838A CN102573523A (zh) 2009-08-11 2010-08-11 包含奇异子和玛咖的膳食补充剂、饲料和药物组合物及其制备方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2009-0073702 2009-08-11
KR20090073702 2009-08-11
KR1020100077099A KR101320374B1 (ko) 2009-08-11 2010-08-11 치아 시드 및 마카를 포함하는 건강보조식품, 사료, 약학 조성물 및 그 제조방법
KR10-2010-0077099 2010-08-11

Publications (3)

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WO2011019210A2 WO2011019210A2 (fr) 2011-02-17
WO2011019210A3 WO2011019210A3 (fr) 2011-06-16
WO2011019210A9 true WO2011019210A9 (fr) 2011-08-04

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Publication number Priority date Publication date Assignee Title
CN103181563A (zh) * 2012-10-28 2013-07-03 赵言林 黑木耳玛卡(maca)复方
CN105360798B (zh) * 2015-01-29 2018-11-16 华中科技大学 一种增强耐力和爆发力的玛咖组方及其制备方法
CN115581300A (zh) * 2018-08-20 2023-01-10 北京姿美堂生物技术有限公司 一种缓解疲劳增强免疫力的组合物及其制备方法
CN114847377A (zh) * 2022-03-28 2022-08-05 山西振东五和医养堂股份有限公司 一种黄精玛咖代茶饮及其制备方法与应用

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US6093421A (en) * 1999-08-31 2000-07-25 Biotics Research Corporation Maca and antler for augmenting testosterone levels
KR20080049330A (ko) * 2006-11-30 2008-06-04 (주)아모레퍼시픽 포만감을 증가시키는 식품 조성물
KR20080079162A (ko) * 2007-02-26 2008-08-29 김연진 치아시드 또는 그 추출물을 함유하는 배합사료와, 그것을사용한 닭 사육방법과, 그로부터 얻어지는 닭고기
KR20080111365A (ko) * 2007-06-18 2008-12-23 주식회사 김경선 케이스퀘어즈 치아시드 커피
KR20090019964A (ko) * 2007-08-22 2009-02-26 주식회사 엘지생활건강 치아 종자를 포함하는 항비만 조성물

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WO2011019210A2 (fr) 2011-02-17

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