WO2010117248A3 - 피에이치 민감성 그라프트 공중합체, 이의 제조방법 및 이를 이용한 고분자 마이셀 - Google Patents

피에이치 민감성 그라프트 공중합체, 이의 제조방법 및 이를 이용한 고분자 마이셀 Download PDF

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WO2010117248A3
WO2010117248A3 PCT/KR2010/002223 KR2010002223W WO2010117248A3 WO 2010117248 A3 WO2010117248 A3 WO 2010117248A3 KR 2010002223 W KR2010002223 W KR 2010002223W WO 2010117248 A3 WO2010117248 A3 WO 2010117248A3
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graft copolymer
micelles
manufacturing
sensitive
sensitive graft
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PCT/KR2010/002223
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French (fr)
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WO2010117248A2 (ko
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이두성
김민상
김봉섭
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성균관대학교산학협력단
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Priority to US13/263,452 priority Critical patent/US9080049B2/en
Publication of WO2010117248A2 publication Critical patent/WO2010117248A2/ko
Publication of WO2010117248A3 publication Critical patent/WO2010117248A3/ko

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Abstract

본 발명은 질환의 진단 및 치료를 위한 다양한 분자영상용 표지자 및 조영제 그리고 질환에 따른 다양한 치료제 전달을 위한 전달체로서 사용 가능할 수 있는 pH 민감성 그라프트 고분자마이셀의 제조 및 상기 그라프트 공중합체를 포함하는 고분자마이셀형 약물 조성물에 관한 것으로서, 보다 상세하게는 pH에 따라 물에 대한 용해도 특성을 갖지만 자기 조립(self assembly) 현상에 의하여 마이셀을 형성하지 못하는 폴리(β- 아미노 에스터) 화합물과 친수성을 나타내는 폴리에틸렌글리콜 계열 화합물과의 그라프트 공중합체를 유도함으로써, 체내 pH 변화에 따라 표적 지향적인 진단 및 치료제 방출이 가능한 마이셀을 형성하는 pH 민감성 그라프트 공중합체, 이의 제조방법 및 이를 이용한 고분자 마이셀을 제공한다.
PCT/KR2010/002223 2009-04-09 2010-04-09 피에이치 민감성 그라프트 공중합체, 이의 제조방법 및 이를 이용한 고분자 마이셀 WO2010117248A2 (ko)

Priority Applications (1)

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US13/263,452 US9080049B2 (en) 2009-04-09 2010-04-09 PH-sensitive graft copolymer, manufacturing method for same, and polymer micelles using method

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Application Number Priority Date Filing Date Title
KR1020090031022A KR101155577B1 (ko) 2009-04-09 2009-04-09 피에이치 민감성 그라프트 공중합체, 이의 제조방법 및 이를 이용한 고분자 마이셀
KR10-2009-0031022 2009-04-09

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WO2010117248A3 true WO2010117248A3 (ko) 2011-03-31

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KR101420922B1 (ko) * 2012-06-29 2014-07-16 성균관대학교산학협력단 온도 및 피에이치 민감성 다중블록 공중합체 및 이의 제조방법
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