WO2010115530A1 - Vorrichtung und verfahren zum nachweis und zur quantitativen analyse von analyten insbesondere mykotoxinen - Google Patents

Vorrichtung und verfahren zum nachweis und zur quantitativen analyse von analyten insbesondere mykotoxinen Download PDF

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Publication number
WO2010115530A1
WO2010115530A1 PCT/EP2010/001924 EP2010001924W WO2010115530A1 WO 2010115530 A1 WO2010115530 A1 WO 2010115530A1 EP 2010001924 W EP2010001924 W EP 2010001924W WO 2010115530 A1 WO2010115530 A1 WO 2010115530A1
Authority
WO
WIPO (PCT)
Prior art keywords
analytes
cartridge
immunoassay
probes
analyte
Prior art date
Application number
PCT/EP2010/001924
Other languages
German (de)
English (en)
French (fr)
Inventor
Jens Burmeister
Ingmar Dorn
Viktoria Bazilyanska
Ulrich Raczek
Original Assignee
Bayer Cropscience Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AP2011005905A priority Critical patent/AP2011005905A0/xx
Priority to BRPI1015212A priority patent/BRPI1015212A2/pt
Priority to JP2012503889A priority patent/JP2012523549A/ja
Priority to EA201171178A priority patent/EA201171178A1/ru
Priority to EP10712339A priority patent/EP2417436A1/de
Priority to CN2010800257383A priority patent/CN102460127A/zh
Application filed by Bayer Cropscience Aktiengesellschaft filed Critical Bayer Cropscience Aktiengesellschaft
Priority to CA2758065A priority patent/CA2758065A1/en
Priority to AU2010234063A priority patent/AU2010234063A1/en
Priority to US13/263,373 priority patent/US20130203613A1/en
Priority to MX2011010586A priority patent/MX2011010586A/es
Publication of WO2010115530A1 publication Critical patent/WO2010115530A1/de
Priority to ZA2011/07242A priority patent/ZA201107242B/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • G01N33/5304Reaction vessels, e.g. agglutination plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
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    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
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    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0325Cells for testing reactions, e.g. containing reagents
    • G01N2021/0328Arrangement of two or more cells having different functions for the measurement of reactions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0346Capillary cells; Microcells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769Measurement method of reaction-produced change in sensor
    • G01N2021/7786Fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/0332Cuvette constructions with temperature control
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274Calibration, base line adjustment, drift correction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37Assays involving biological materials from specific organisms or of a specific nature from fungi
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02Food
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02Food
    • G01N33/10Starch-containing substances, e.g. dough
PCT/EP2010/001924 2009-04-09 2010-03-26 Vorrichtung und verfahren zum nachweis und zur quantitativen analyse von analyten insbesondere mykotoxinen WO2010115530A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BRPI1015212A BRPI1015212A2 (pt) 2009-04-09 2010-03-26 dispositivo e método para a detecção e para a análise quantitativa de analitos, especialmente micotoxinas
JP2012503889A JP2012523549A (ja) 2009-04-09 2010-03-26 分析物、特にマイコトキシンの検証および定量分析のための装置および方法
EA201171178A EA201171178A1 (ru) 2009-04-09 2010-03-26 Устройство и способ для определения и количественного анализа аналитов, в частности, микотоксинов
EP10712339A EP2417436A1 (de) 2009-04-09 2010-03-26 Vorrichtung und verfahren zum nachweis und zur quantitativen analyse von analyten insbesondere mykotoxinen
CN2010800257383A CN102460127A (zh) 2009-04-09 2010-03-26 用于识别和定量分析被分析物,特别是真菌毒素的装置和方法
AP2011005905A AP2011005905A0 (en) 2009-04-09 2010-03-26 Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins.
CA2758065A CA2758065A1 (en) 2009-04-09 2010-03-26 Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins
AU2010234063A AU2010234063A1 (en) 2009-04-09 2010-03-26 Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins
US13/263,373 US20130203613A1 (en) 2009-04-09 2010-03-26 Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins
MX2011010586A MX2011010586A (es) 2009-04-09 2010-03-26 Dispositivo y procedimiento para la verificacion y para el analisis cuantitativo de analitos, particularmente de micotoxinas.
ZA2011/07242A ZA201107242B (en) 2009-04-09 2011-10-04 Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09157714 2009-04-09
EP09157714.8 2009-04-09

Publications (1)

Publication Number Publication Date
WO2010115530A1 true WO2010115530A1 (de) 2010-10-14

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Family Applications (1)

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PCT/EP2010/001924 WO2010115530A1 (de) 2009-04-09 2010-03-26 Vorrichtung und verfahren zum nachweis und zur quantitativen analyse von analyten insbesondere mykotoxinen

Country Status (18)

Country Link
US (1) US20130203613A1 (pt-PT)
EP (1) EP2417436A1 (pt-PT)
JP (1) JP2012523549A (pt-PT)
KR (1) KR20120014122A (pt-PT)
CN (1) CN102460127A (pt-PT)
AP (1) AP2011005905A0 (pt-PT)
AR (1) AR076201A1 (pt-PT)
AU (1) AU2010234063A1 (pt-PT)
BR (1) BRPI1015212A2 (pt-PT)
CA (1) CA2758065A1 (pt-PT)
CL (1) CL2011002509A1 (pt-PT)
CO (1) CO6440576A2 (pt-PT)
CR (1) CR20110530A (pt-PT)
EA (1) EA201171178A1 (pt-PT)
EC (1) ECSP11011376A (pt-PT)
MX (1) MX2011010586A (pt-PT)
WO (1) WO2010115530A1 (pt-PT)
ZA (1) ZA201107242B (pt-PT)

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KR101335032B1 (ko) * 2012-11-06 2013-12-02 (주)플렉센스 시료의 정량적 분석을 위한 시료측정 카트리지 및 시료 정량 분석 장치
US9812597B2 (en) * 2014-08-12 2017-11-07 Personal Genomics, Inc. Optical sensor and manufacturing method thereof
MY192651A (en) * 2015-09-14 2022-08-29 Essenlix Corp Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same
WO2018008309A1 (ja) * 2016-07-05 2018-01-11 コニカミノルタ株式会社 生体物質定量方法、画像処理装置、病理診断支援システム及びプログラム
ES2703686T3 (es) * 2016-07-18 2019-03-12 R Biopharm Ag Método para la extracción de micotoxinas a partir de cereales, otros alimentos y piensos
KR101999260B1 (ko) * 2016-09-30 2019-07-12 삼성전자주식회사 검체 분석 장치 및 그 측정방법
NL2021691B1 (en) * 2018-09-24 2020-05-07 Lely Patent Nv Milking system with detection system
CN111742212B (zh) 2019-01-08 2024-02-20 京东方科技集团股份有限公司 流体检测面板和流体检测装置
CN109632660B (zh) * 2019-01-17 2022-04-05 京东方科技集团股份有限公司 流体检测面板
WO2021020072A1 (ja) * 2019-07-29 2021-02-04 エイブル株式会社 センサ素子の製造方法、センサ素子、センサ素子保持体及び蛍光式センサシステム

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WO2004023142A1 (de) 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
DE10313515A1 (de) * 2001-09-28 2004-10-14 Biotez Berlin-Buch Gmbh Biochip zum quantitativen fotometrischen Nachweis von Biomolekülen
WO2005088300A1 (en) 2004-03-16 2005-09-22 Fuji Photo Film Co., Ltd. Assay chip
WO2007079893A1 (de) 2005-12-23 2007-07-19 Bayer Technology Services Gmbh Vorrichtung und verfahren zum nachweis von mykotoxinen

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EP0093613A1 (en) 1982-05-04 1983-11-09 Syva Company Simultaneous calibration heterogeneous immunoassay method, apparatus and diagnostic kit
US5959292A (en) 1994-05-27 1999-09-28 Novartis Corporation Process for detecting evanescently excited luminescence
WO1999052633A1 (en) * 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
WO2001013096A1 (de) 1999-08-13 2001-02-22 Zeptosens Ag Vorrichtung und verfahren zur multianalytbestimmung
DE10313515A1 (de) * 2001-09-28 2004-10-14 Biotez Berlin-Buch Gmbh Biochip zum quantitativen fotometrischen Nachweis von Biomolekülen
WO2004023142A1 (de) 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
WO2005088300A1 (en) 2004-03-16 2005-09-22 Fuji Photo Film Co., Ltd. Assay chip
WO2007079893A1 (de) 2005-12-23 2007-07-19 Bayer Technology Services Gmbh Vorrichtung und verfahren zum nachweis von mykotoxinen

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AU2010234063A1 (en) 2011-11-03
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