WO2010090471A3 - 제1형 당뇨병의 신규한 진단 마커 - Google Patents
제1형 당뇨병의 신규한 진단 마커 Download PDFInfo
- Publication number
- WO2010090471A3 WO2010090471A3 PCT/KR2010/000710 KR2010000710W WO2010090471A3 WO 2010090471 A3 WO2010090471 A3 WO 2010090471A3 KR 2010000710 W KR2010000710 W KR 2010000710W WO 2010090471 A3 WO2010090471 A3 WO 2010090471A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- type
- diabetes mellitus
- trna synthetase
- diagnosis
- antibodies
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
본 발명은 제1형 당뇨병의 신규한 진단 마커에 관한 것으로, 아미노아실 tRNA 합성효소 또는 이에 대한 항체를 유효성분으로 포함하는 제1형 당뇨병의 진단용 조성물, 아미노아실 tRNA 합성효소의 제1형 당뇨병 진단용 제제의 제조를 위한 용도 및 개체의 시료로부터 항-알라닌 tRNA 합성효소 항체, 항-글리신 tRNA 합성효소 항체, 항-아스파라긴 tRNA 합성효소 항체 및 항-트립토판 tRNA 합성효소 항체를 검출하는 제1형 당뇨병 진단 방법에 관한 것이다. 본 발명의 조성물, 키트 및 방법은 환자의 시료로부터 손쉽게 제1형 당뇨병 여부를 진단할 수 있으므로 제1형 당뇨병의 조기 진단 및 확정을 위하여 사용할 수 있다.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011549067A JP5571696B2 (ja) | 2009-02-05 | 2010-02-05 | 第1型糖尿病の新規な診断マーカー |
EP10738755.7A EP2395100B1 (en) | 2009-02-05 | 2010-02-05 | Novel diagnostic marker for type 1 diabetes mellitus |
CN2010800067618A CN102308002A (zh) | 2009-02-05 | 2010-02-05 | 第一型糖尿病的新型诊断标志物 |
US13/198,990 US8563327B2 (en) | 2009-02-05 | 2011-08-05 | Diagnostic marker for type 1 diabetes mellitus |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2009-0009231 | 2009-02-05 | ||
KR1020090009231A KR101067815B1 (ko) | 2009-02-05 | 2009-02-05 | 제1형 당뇨병의 신규한 진단 마커 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/198,990 Continuation US8563327B2 (en) | 2009-02-05 | 2011-08-05 | Diagnostic marker for type 1 diabetes mellitus |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2010090471A2 WO2010090471A2 (ko) | 2010-08-12 |
WO2010090471A3 true WO2010090471A3 (ko) | 2010-11-18 |
WO2010090471A9 WO2010090471A9 (ko) | 2011-01-06 |
Family
ID=42542522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2010/000710 WO2010090471A2 (ko) | 2009-02-05 | 2010-02-05 | 제1형 당뇨병의 신규한 진단 마커 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8563327B2 (ko) |
EP (1) | EP2395100B1 (ko) |
JP (1) | JP5571696B2 (ko) |
KR (1) | KR101067815B1 (ko) |
CN (1) | CN102308002A (ko) |
WO (1) | WO2010090471A2 (ko) |
Cited By (5)
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US8835387B2 (en) | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
US9322009B2 (en) | 2010-06-01 | 2016-04-26 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
US9528103B2 (en) | 2010-04-27 | 2016-12-27 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
US9593323B2 (en) | 2010-05-03 | 2017-03-14 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
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JP5771142B2 (ja) * | 2008-06-11 | 2015-08-26 | エータイアー ファーマ, インコーポレイテッド | チロシル−tRNAシンテターゼポリペプチドの血小板新生活性 |
WO2009158649A1 (en) | 2008-06-26 | 2009-12-30 | Atyr Pharma, Inc. | Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities |
WO2010099477A2 (en) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
DK3255146T3 (da) | 2009-03-16 | 2019-08-19 | Pangu Biopharma Ltd | Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter |
US20100310576A1 (en) * | 2009-03-31 | 2010-12-09 | Adams Ryan A | COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES |
CA2783731C (en) | 2009-12-11 | 2018-03-27 | Atyr Pharma, Inc. | Aminoacyl trna synthetases for modulating inflammation |
US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
US20110150885A1 (en) * | 2009-12-11 | 2011-06-23 | Atyr Pharma, Inc. | Aminoacyl trna synthetases for modulating hematopoiesis |
US8980253B2 (en) | 2010-04-26 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
US8986681B2 (en) | 2010-04-27 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases |
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CN105543400B (zh) * | 2016-02-29 | 2018-12-25 | 北京泱深生物信息技术有限公司 | I型糖尿病的分子标志物 |
JP2020517638A (ja) | 2017-04-20 | 2020-06-18 | エータイアー ファーマ, インコーポレイテッド | 肺の炎症を治療するための組成物および方法 |
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US20060073134A1 (en) * | 2002-03-20 | 2006-04-06 | Syddansk Universitet | Human diabetes-mediating proteins |
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- 2009-02-05 KR KR1020090009231A patent/KR101067815B1/ko active IP Right Grant
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2010
- 2010-02-05 WO PCT/KR2010/000710 patent/WO2010090471A2/ko active Application Filing
- 2010-02-05 CN CN2010800067618A patent/CN102308002A/zh active Pending
- 2010-02-05 EP EP10738755.7A patent/EP2395100B1/en active Active
- 2010-02-05 JP JP2011549067A patent/JP5571696B2/ja active Active
-
2011
- 2011-08-05 US US13/198,990 patent/US8563327B2/en active Active
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9528103B2 (en) | 2010-04-27 | 2016-12-27 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
US9593323B2 (en) | 2010-05-03 | 2017-03-14 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
US9322009B2 (en) | 2010-06-01 | 2016-04-26 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
US8835387B2 (en) | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
Also Published As
Publication number | Publication date |
---|---|
KR20100090003A (ko) | 2010-08-13 |
CN102308002A (zh) | 2012-01-04 |
WO2010090471A2 (ko) | 2010-08-12 |
US8563327B2 (en) | 2013-10-22 |
JP2012517014A (ja) | 2012-07-26 |
US20120015383A1 (en) | 2012-01-19 |
EP2395100B1 (en) | 2014-09-17 |
JP5571696B2 (ja) | 2014-08-13 |
KR101067815B1 (ko) | 2011-09-27 |
EP2395100A2 (en) | 2011-12-14 |
EP2395100A4 (en) | 2012-08-01 |
WO2010090471A9 (ko) | 2011-01-06 |
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