WO2010053085A1 - Agent de prévention de l'acidose chez des ruminants - Google Patents

Agent de prévention de l'acidose chez des ruminants Download PDF

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Publication number
WO2010053085A1
WO2010053085A1 PCT/JP2009/068812 JP2009068812W WO2010053085A1 WO 2010053085 A1 WO2010053085 A1 WO 2010053085A1 JP 2009068812 W JP2009068812 W JP 2009068812W WO 2010053085 A1 WO2010053085 A1 WO 2010053085A1
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WO
WIPO (PCT)
Prior art keywords
acidosis
cashew nut
nut shell
feed
shell liquid
Prior art date
Application number
PCT/JP2009/068812
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English (en)
Japanese (ja)
Inventor
千枝 鈴木
協 長嶋
正己 望月
Original Assignee
出光興産株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 出光興産株式会社 filed Critical 出光興産株式会社
Priority to JP2010536772A priority Critical patent/JPWO2010053085A1/ja
Publication of WO2010053085A1 publication Critical patent/WO2010053085A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to an acidosis control agent containing cashew nut shell liquid and / or anacardic acid.
  • Rapid mass feeding of fermentable cereal feed to ruminants produces a large amount of lactic acid in the rumen and causes rumen acidosis, mainly acute gastrointestinal disorders. In the field, this disease can be observed even if the food is stolen such as ground corn or starch or overeating them. Natural feeding is not enough to get sick and get sick. It is no exaggeration to say that many cows are in a preparatory state of this disease in Japan, which is a high-concentration feed system.
  • lactic acid producing bacteria such as Streptococcus bovis and Ruminococcus
  • the lactic acid in the stomach content increases, resulting in a pH drop of 6 or less.
  • fiber-degrading bacteria and protozoa will die and disappear.
  • L-lactic acid is metabolized in the liver, but D-lactic acid is not metabolized or is slowly metabolized, so it is absorbed into the body and causes acidosis due to a decrease in blood pH. Mild cases have transient loss of appetite, reduced rumen movement, reduced milk yield and fat content, grayish white stools, and rumen contents are watery.
  • Cashew nut shell liquid and / or anacardic acid are known to have a coccidiosis-reducing action (Patent Document 1) and an antibacterial action (Non-Patent Document 2), but there is absolutely no knowledge about the preventive and therapeutic effects of ruminant acidosis. No. In addition, the effect of cashew nut shell liquid and / or anacardic acid on acidosis has not been confirmed.
  • An object of the present invention is to control ruminant acidosis.
  • the gist of the present invention is as follows.
  • An acidosis control agent comprising cashew nut shell liquid and / or anacardic acid.
  • a composition for a feed for controlling acidosis comprising cashew nut shell liquid and / or anacardic acid.
  • a composition for feed for controlling acidosis comprising the acidosis controlling agent according to (1).
  • a feed for controlling acidosis comprising the composition for feed for controlling acidosis according to (4).
  • a method for controlling acidosis comprising administering cashew nut shell liquid and / or anacardic acid to a ruminant that has developed acidosis.
  • the method for controlling acidosis according to (6) wherein cashew nut shell liquid and / or anacardic acid is administered in an amount of 1 to 1,000 g / head / day.
  • the acidosis control agent of the present invention can treat acidosis by being administered to ruminants that have developed acidosis.
  • the acidosis control agent of the present invention can also prevent acidosis by administering it to ruminants that have not developed acidosis. Since the acidosis control agent of the present invention can control rumen parakeratosis, rumen gastritis, and chronic acidosis that is liable to cause liver abscess, the growth of beef cattle is improved and the milk yield of milking cows is increased.
  • the ruminant acidosis control agent of the present invention is characterized by containing cashew nut shell liquid and / or anacardic acid.
  • control includes prevention and treatment.
  • the cashew nut shell liquid used in the present invention is an oily liquid contained in the shell of the cashew nut tree ( Anacardium occidentale L.).
  • Cashew nut shell oil contains anacardic acid, cardanol, and cardol as its components.
  • anacardic acid is a main component for the expression of its activity, a higher ratio of anacardic acid is preferable.
  • the cashew nut shell oil used in the present invention can be obtained as a vegetable oil extracted by pressing the cashew nut shell.
  • the cashew nut shell oil used in the present invention can also be obtained by, for example, dry distillation or solvent extraction of the cashew nut shell by heating or extraction.
  • the cashew nut shell liquid used in the present invention can also be obtained by the method described in JP-A-8-231410.
  • the cashew nut shell oil used in the present invention may be obtained by crushing and crushing cashew nut shells without heating. Moreover, the shell itself may be sufficient.
  • a commercial item can also be used for the cashew nut shell liquid used in this invention.
  • anacardic acid used in the present invention examples include natural products anacardic acid, synthetic anacardic acid, and derivatives thereof. Commercial anacardic acid may also be used.
  • anacardic acid is obtained by using cashew nut oil obtained by extracting cashew nut shells with an organic solvent using, for example, silica gel column chromatography, n-hexane, acetic acid. It can be obtained by changing the ratio of the mixed solvent of ethyl and acetic acid (JP-A-3-240721, JP-A-3-240716, etc.).
  • the content of cashew nut shell liquid and / or anacardic acid in the acidosis control agent of the present invention is preferably 1% by mass to 100% by mass, more preferably 5% by mass to 95% by mass, particularly based on the total amount of the control agent.
  • the content is preferably 10% by mass to 90% by mass. If it is 1 mass% or more, even if a ruminant is grown in an environment in which a concentrated feed is frequently fed, it can be expected to maintain the pH in the rumen in a neutral range. Moreover, foam formation can also be suppressed and the disease can be effectively controlled. If it is 5 mass% or more, Most preferably, it is 10 mass% or more, The tendency becomes remarkable and is preferable.
  • the pH in the lumen can be maintained in a neutral range even at 100% by mass, but it is preferably 95% by mass or less, particularly preferably 90% by mass or less, in order to improve the palatability of ruminants.
  • a stock solution of cashew nut shell liquid and / or anacardic acid can be directly orally administered.
  • the dose of cashew nut shell liquid and / or anacardic acid is preferably 1 to 1,000 g / head / day, more preferably 10 to 200 g / day. Head / day, most preferably 35-100 g / head / day. If it is 1 g / head / day or more, it can be expected that the pH in the rumen will be maintained in the neutral range even when grown in an environment in which a concentrated feed is fed frequently to ruminants.
  • foam formation can also be suppressed and a disease can be controlled effectively. If it is 10 g or more, particularly preferably 35 g or more, the tendency becomes remarkable, which is preferable.
  • the pH within the lumen can be maintained in the neutral range even at 1,000 g or less, it is preferably 200 g or less, particularly preferably 100 g or less, in order to improve the palatability of ruminants.
  • the acidosis control agent of the present invention can be used for controlling acidosis in ruminants.
  • acidosis means that the pH of the rumen content (ruminal fluid) in the rumen of a ruminant falls to 6.5 or less, more strictly 6.0 or less.
  • the acidosis controlling agent in the present invention can be used for controlling acidosis caused by large-scale administration of easily fermentable grain feed or concentrated feed.
  • the acidosis control agent of the present invention is applied to feeds or pharmaceuticals or foods such as lactose, sucrose, D-mannitol, starch, corn starch, crystalline cellulose, silica gel, and light anhydrous silicic acid. Any excipient may be included as long as it can be used.
  • the acidosis control agent of the present invention includes, in addition to cashew nut shell liquid and / or anacardic acid, optional components such as a component effective for promoting the growth of ruminants, a nutritional supplement component, a component that enhances storage stability, and a coating component component. May further be included.
  • optional components include feed raw materials and feed additives, food raw materials and food additives, and pharmaceutical raw materials.
  • live bacteria such as Enterococcus bacteria, Bacillus bacteria, bifidobacteria; enzymes such as amylase and lipase; vitamins such as L-ascorbic acid, choline chloride, inositol and folic acid; potassium chloride, iron citrate, magnesium oxide, Minerals such as phosphates, amino acids such as DL-alanine, DL-methionine, L-lysine; organic acids such as fumaric acid, butyric acid, lactic acid, acetic acid and their salts; ethoxyquin, dibutylhydroxytoluene, butylhydroxyanisole, ferla Antioxidants such as acid, vitamin C, and vitamin E; Antifungal agents such as calcium propionate; Binders such as carboxymethylcellulose (CMC), sodium caseinate, and sodium polyacrylate; lecithin, glycerin fatty acid ester, sorbitan fatty acid ester Emulsifiers such as Examples thereof include pigment
  • the dosage form of the acidosis control agent of the present invention is not particularly limited, and examples thereof include powders, liquids, solids, tablets, capsules, emulsions, pellets, coatings and the like, but powders, liquids, capsules, etc. , Pellets and coatings are preferred.
  • filler can be added to cashew nut shell liquid and / or anacardic acid, and can also be pulverized.
  • cashew nut shell liquid and / or anacardic acid may be used as they are, cashew nut shell liquid and / or anacardic acid may be dissolved in a solvent such as ethanol, or the above-mentioned excipients or optional components are added. It can also be used.
  • a capsule cashew nut shell liquid and / or anacardic acid may be packed in a capsule as it is, or the above-mentioned excipients or optional components may be added.
  • filler is added to cashew nut shell liquid and / or anacardic acid, and it can also granulate and pelletize.
  • the coating agent the above excipients may be added to and granulated in cashew nut shell liquid and / or anacardic acid, and then coated with a coating agent or the like.
  • the acidosis control agent of the present invention can be produced by mixing cashew nut shell liquid and / or anacardic acid and, if necessary, an excipient or an optional component and formulating it.
  • the above-described acidosis control agent of the present invention can be obtained by pulverizing and pulverizing cashew nut shells, or by directly mixing cashew nut shells with other optional components without any treatment.
  • the crushed and crushed material itself or the cashew nut shell itself can be used as an acidosis control agent, and the acidosis control agent itself can be used as a feed composition or feed.
  • cashew nut shell liquid and / or anacardic acid can be dissolved in a solvent such as ethanol, and this can be mixed and absorbed in a feed composition or feed.
  • the acidosis control agent of the present invention contains an effective amount of cashew nut shell liquid and / or anacardic acid.
  • the feed composition of the present invention is characterized by containing cashew nut shell liquid and / or anacardic acid.
  • the content of cashew nut shell liquid and / or anacardic acid in the feed composition of the present invention is preferably 0.0005 mass% to 100 mass%, more preferably 0.05 to 95 mass%, particularly preferably based on the total amount. 1 to 90% by mass. If it is 0.0005 mass% or more, even if a ruminant is grown in an environment in which a concentrated feed is frequently fed, it can be expected to maintain the pH in the rumen in a neutral range. Moreover, foam formation can also be suppressed and a disease can be controlled effectively.
  • the acidosis control agent of the present invention can be mixed with other supplement components used in animal supplements (hereinafter referred to as supplements) to obtain supplements.
  • the type of supplement and ingredients other than cashew nut shell liquid and / or anacardic acid are not particularly limited.
  • the feed of the present invention is characterized by containing cashew nut shell liquid and / or anacardic acid.
  • the content of cashew nut shell liquid and / or anacardic acid in the feed of the present invention is preferably 0.5 to 500,000 mass ppm, more preferably 5 to 300,000 mass based on the total amount of dry matter in the feed. ppm, particularly preferably 50 to 100,000 ppm by mass. If it is 0.5 mass ppm or more, even if a ruminant is grown in an environment in which a concentrated feed is frequently fed, it can be expected to maintain the pH in the rumen in a neutral range. Moreover, foam formation can also be suppressed and a disease can be controlled effectively.
  • the pH in the lumen can be maintained in a neutral range even at 500,000 mass ppm, it is preferably 300,000 mass ppm or less, particularly preferably 100,000 mass ppm or less, for improving the palatability of ruminants. .
  • the feed of the present invention can be produced by adding cashew nut shell liquid and / or anacardic acid as they are or adding a feed composition containing cashew nut shell liquid and / or anacardic acid to the feed ingredients and mixing them.
  • the feed composition may be in a liquid or gel form to facilitate mixing.
  • fluid liquids such as water, vegetable oils, liquid animal oils, mineral oils, synthetic oils, and water-soluble polymer compounds can be used as the liquid carrier.
  • water-soluble polysaccharides such as alginic acid, sodium alginate, xanthan gum, sodium caseinate, gum arabic, guar gum, tamarind seed polysaccharide should be added. Is also preferable.
  • the kind of animal that feeds the feed of the present invention is a ruminant.
  • the feed of the present invention is suitable for breeding ruminants such as cows, goats and sheep.
  • the amount of feed to be ingested can be appropriately adjusted according to the type of animal, body weight, age, sex, health condition, feed components, etc.
  • cashew nut nut shell liquid contained in the feed is preferably 1 to 1,000 g. / Head / day, more preferably 10 to 200 g / head / day, still more preferably 35 to 100 g / head / day.
  • a method for ingesting and rearing a feed a commonly used method can be employed depending on the type of animal.
  • a cashew nut shell (500 kg) was obtained from Cashew Trading Co., Ltd. and pressed to produce 158 kg of cashew nut shell oil (CNSL).
  • the composition of cashew nut shell liquid was measured by the following method. Specifically, HPLC (Waters 600, Nippon Waters Co., Ltd.), detector (Waters 490E, Nihon Waters Co., Ltd.), printer (Chromatopack C-R6A, Shimadzu Corporation), column (SUPELCOSIL LC18, SUPELCO) were used.
  • a solvent of acetonitrile: water: acetic acid of 80: 20: 1 (volume ratio) was used, and the flow rate was 2 ml / min.
  • CNSL contained 61.8% by mass of anacardic acid, 8.2% by mass of cardanol, and 19.9% by mass of cardol.
  • CNSL (15 kg) was dissolved in 30 L of ethanol, and mixed and absorbed in 75 kg of barley (barley pressure barley, Matsukage Seiwa Co., Ltd. product). The ethanol was removed by lyophilization to obtain 90 kg of barley penne with CNSL.
  • Examples for testing 67 months old, weighing approximately 600 kg, and adult female Holstein cows were used for the test.
  • the administration start day was the 0th day.
  • Feeding of the feed (feed coarse ratio 3: 9) was started on the 0th day, and was adjusted to the concentrated feed.
  • the daily feed was 3 kg of rice straw as rough feed, 8 kg of feed for late fattening (a product of the National Dairy Cooperative Association) and 1 kg of barley as concentrated feed, and was fed from day 0 to day 66.
  • 200 g of barley was removed, and 200 g of barley with CNSL was added instead (CNSL, 33 g / head / day).
  • the pH of the rumen solution was improved by administering 33 g / head / day of cashew nut shell liquid, and the pH of the rumen solution was substantially improved by administering 67 g / head / day of rice. Symptom was completely relieved by administration of 100 g / head / day. Cashew nut shell liquid and / or anacardic acid is considered to have an acidosis control effect.
  • Acidosis can be controlled by administering cashew nut shell liquid and / or anacardic acid to ruminants that have developed acidosis. Moreover, in an acute severe case, it may become a coma and may die, but the acidosis control agent of this invention can control the acidosis of an acute severe case. In chronic acidosis, rumen parakeratosis, rumen gastritis, and liver abscess are likely to occur, and because of poor milk production and reproductive performance and poor growth, good quality meat cannot be obtained and it can not be sold high. Since the acidosis control agent of the invention can control chronic acidosis, productivity can be improved.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Feed For Specific Animals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention porte sur un agent de prévention de l'acidose qui est caractérisé en ce qu'il comprend un baume de cajou et/ou de l'acide anacardique.
PCT/JP2009/068812 2008-11-04 2009-11-04 Agent de prévention de l'acidose chez des ruminants WO2010053085A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010536772A JPWO2010053085A1 (ja) 2008-11-04 2009-11-04 反芻動物のアシドーシス防除剤

Applications Claiming Priority (2)

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JP2008-283066 2008-11-04
JP2008283066 2008-11-04

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WO2010053085A1 true WO2010053085A1 (fr) 2010-05-14

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AR (1) AR074190A1 (fr)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012093533A1 (fr) 2011-01-07 2012-07-12 出光興産株式会社 Agent capable d'améliorer le rendement en lait et/ou la qualité du lait des ruminants, agent préventif ou thérapeutique des maladies périnatales et agent capable d'améliorer l'efficacité de la reproduction
AU2015252032B2 (en) * 2011-01-07 2016-07-07 Sds Biotech K.K. Agent for improving milk yield and/or milk quality of ruminants, preventive or therapeutic agent for perinatal disease, and agent for improving reproductive efficiency
AU2016204291B2 (en) * 2011-01-07 2016-12-22 Sds Biotech K.K. Agent for improving milk yield and/or milk quality of ruminants, preventive or therapeutic agent for perinatal disease, and agent for improving reproductive efficiency
WO2021085584A1 (fr) 2019-10-31 2021-05-06 出光興産株式会社 Inhibiteur de résistance à l'insuline pour animaux ruminants
WO2021112171A1 (fr) 2019-12-03 2021-06-10 出光興産株式会社 Agent anti-inflammatoire pour cellule intestinale
WO2022250027A1 (fr) 2021-05-28 2022-12-01 株式会社エス・ディー・エス バイオテック Agent anti-inflammatoire pour cellules intestinales d'un animal domestique

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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015252032B2 (en) * 2011-01-07 2016-07-07 Sds Biotech K.K. Agent for improving milk yield and/or milk quality of ruminants, preventive or therapeutic agent for perinatal disease, and agent for improving reproductive efficiency
JP2014210808A (ja) * 2011-01-07 2014-11-13 出光興産株式会社 反芻動物の周産期病の予防または治療剤
WO2012093533A1 (fr) 2011-01-07 2012-07-12 出光興産株式会社 Agent capable d'améliorer le rendement en lait et/ou la qualité du lait des ruminants, agent préventif ou thérapeutique des maladies périnatales et agent capable d'améliorer l'efficacité de la reproduction
US8859015B2 (en) 2011-01-07 2014-10-14 Idemitsu Kosan Co., Ltd. Milk yield and/or milk quality improving agent, perinatal disease preventive or therapeutic agent, and reproductivity improving agent for ruminant
KR20160132136A (ko) 2011-01-07 2016-11-16 이데미쓰 고산 가부시키가이샤 반추 동물의 유량 및/또는 유질 향상제, 주산기병 예방 또는 치료제, 그리고 번식 효율 개선제
JP2014239690A (ja) * 2011-01-07 2014-12-25 出光興産株式会社 反芻動物の繁殖効率改善剤
JP5651195B2 (ja) * 2011-01-07 2015-01-07 出光興産株式会社 反芻動物の乳量及び／または乳質向上剤、周産期病予防または治療剤、並びに繁殖効率改善剤
AU2016204291B2 (en) * 2011-01-07 2016-12-22 Sds Biotech K.K. Agent for improving milk yield and/or milk quality of ruminants, preventive or therapeutic agent for perinatal disease, and agent for improving reproductive efficiency
CN104288196A (zh) * 2011-01-07 2015-01-21 出光兴产株式会社 反刍动物乳量和/或乳质提高剂、围产期病的预防或治疗剂及繁殖效率改善剂
CN104382970A (zh) * 2011-01-07 2015-03-04 出光兴产株式会社 反刍动物乳量和/或乳质提高剂、围产期病的预防或治疗剂及繁殖效率改善剂
AU2011353949B2 (en) * 2011-01-07 2015-08-06 Sds Biotech K.K. Agent for improving milk yield and/or milk quality of ruminants, preventive or therapeutic agent for perinatal disease, and agent for improving reproductive efficiency
US9238048B2 (en) 2011-01-07 2016-01-19 Idemitsu Kosan Co., Ltd. Milk yield and/or milk quality improving agent, perinatal disease preventive or therapeutic agent, and reproductivity improving agent for ruminant
US8697148B2 (en) 2011-01-07 2014-04-15 Idemitsu Kosan Co., Ltd. Milk yield and/or milk quality improving agent, perinatal disease preventive or therapeutic agent, and reproductivity improving agent for ruminant
CN103313608A (zh) * 2011-01-07 2013-09-18 出光兴产株式会社 反刍动物乳量和/或乳质提高剂、围产期病的预防或治疗剂及繁殖效率改善剂
CN104288195A (zh) * 2011-01-07 2015-01-21 出光兴产株式会社 反刍动物乳量和/或乳质提高剂、围产期病的预防或治疗剂及繁殖效率改善剂
KR20170064566A (ko) 2011-01-07 2017-06-09 이데미쓰 고산 가부시키가이샤 반추 동물의 유량 및/또는 유질 향상제, 주산기병 예방 또는 치료제, 그리고 번식 효율 개선제
KR101751097B1 (ko) * 2011-01-07 2017-06-26 이데미쓰 고산 가부시키가이샤 반추 동물의 유량 및/또는 유질 향상제, 주산기병 예방 또는 치료제, 그리고 번식 효율 개선제
US9694041B2 (en) 2011-01-07 2017-07-04 Idemitsu Kosan Co., Ltd. Milk yield and/or milk quality improving agent, perinatal disease preventive or therapeutic agent, and reproductivity improving agent for ruminant
KR101865525B1 (ko) * 2011-01-07 2018-06-07 이데미쓰 고산 가부시키가이샤 반추 동물의 유량 및/또는 유질 향상제, 주산기병 예방 또는 치료제, 그리고 번식 효율 개선제
EP3466437A1 (fr) 2011-01-07 2019-04-10 Idemitsu Kosan Co., Ltd. Agent préventif ou thérapeutique de maladies périnatales pour ruminant
EP3848042A1 (fr) 2011-01-07 2021-07-14 Idemitsu Kosan Co.,Ltd. Agent agent d'amélioration de la reproductibilité pour ruminant
WO2021085584A1 (fr) 2019-10-31 2021-05-06 出光興産株式会社 Inhibiteur de résistance à l'insuline pour animaux ruminants
KR20220092505A (ko) 2019-10-31 2022-07-01 이데미쓰 고산 가부시키가이샤 반추 동물의 인슐린 저항성 억제제
WO2021112171A1 (fr) 2019-12-03 2021-06-10 出光興産株式会社 Agent anti-inflammatoire pour cellule intestinale
WO2022250027A1 (fr) 2021-05-28 2022-12-01 株式会社エス・ディー・エス バイオテック Agent anti-inflammatoire pour cellules intestinales d'un animal domestique

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