WO2010043106A1 - 可注射原位交联水凝胶及其制备方法和用途 - Google Patents
可注射原位交联水凝胶及其制备方法和用途 Download PDFInfo
- Publication number
- WO2010043106A1 WO2010043106A1 PCT/CN2009/001013 CN2009001013W WO2010043106A1 WO 2010043106 A1 WO2010043106 A1 WO 2010043106A1 CN 2009001013 W CN2009001013 W CN 2009001013W WO 2010043106 A1 WO2010043106 A1 WO 2010043106A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- injectable
- crosslinked hydrogel
- cross
- solution
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011531327A JP5657545B2 (ja) | 2008-10-16 | 2009-09-08 | 注射用容器内で架橋した注射用ヒドロゲルの調製方法 |
EP09820182.5A EP2353612B1 (en) | 2008-10-16 | 2009-09-08 | Injectable in-situ crosslinked hydrogel and the preparation method and use thereof |
US13/124,412 US9220676B2 (en) | 2008-10-16 | 2009-09-08 | Injectable in-situ crosslinked hydrogel and methods of making and using thereof |
ES09820182.5T ES2664269T3 (es) | 2008-10-16 | 2009-09-08 | Hidrogel reticulado inyectable in situ y el procedimiento de preparación y uso del mismo |
AU2009304472A AU2009304472B2 (en) | 2008-10-16 | 2009-09-08 | Injectable in-situ crosslinked hydrogel and the preparation method and use thereof |
CA2740136A CA2740136C (en) | 2008-10-16 | 2009-09-08 | Injectable in-situ crosslinked hydrogel and methods of making and using thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200810043845.3 | 2008-10-16 | ||
CN2008100438453A CN101721349B (zh) | 2008-10-16 | 2008-10-16 | 可注射原位交联水凝胶及其制备方法和用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010043106A1 true WO2010043106A1 (zh) | 2010-04-22 |
Family
ID=42106207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2009/001013 WO2010043106A1 (zh) | 2008-10-16 | 2009-09-08 | 可注射原位交联水凝胶及其制备方法和用途 |
Country Status (8)
Country | Link |
---|---|
US (1) | US9220676B2 (zh) |
EP (1) | EP2353612B1 (zh) |
JP (1) | JP5657545B2 (zh) |
CN (1) | CN101721349B (zh) |
AU (1) | AU2009304472B2 (zh) |
CA (1) | CA2740136C (zh) |
ES (1) | ES2664269T3 (zh) |
WO (1) | WO2010043106A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013021249A1 (en) * | 2011-08-10 | 2013-02-14 | Glycores 2000 S.R.L. | Degradation-resistant cross-linked, low-molecular-weight hyaluronate |
US9446067B2 (en) | 2010-09-09 | 2016-09-20 | Bioregen Biomedical (Changzhou) Co. Ltd. | Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2852386C (en) * | 2011-10-17 | 2019-05-21 | Poly-Med, Inc. | Absorbable in situ gel-forming system, method of making and use thereof |
EP2900808B1 (en) | 2012-09-28 | 2019-04-03 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
JP6324395B2 (ja) | 2012-10-29 | 2018-05-16 | スクリップス ヘルス | 軟骨細胞を移植する方法 |
WO2014070797A1 (en) | 2012-10-29 | 2014-05-08 | Scripps Health | Methods of producing pluripotent stem cells from chondrocytes |
CN104128136B (zh) * | 2013-05-03 | 2017-06-30 | 中国科学院化学研究所 | 微纳米凝胶粒子及其可控制备方法与应用 |
CN103665400B (zh) * | 2013-11-12 | 2016-01-13 | 张家界本草科技有限公司 | 白芨止血凝胶的制备方法及应用 |
US10294195B2 (en) | 2014-01-31 | 2019-05-21 | Seikagaku Corporation | Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials |
CN104194008B (zh) * | 2014-08-08 | 2017-09-15 | 陕西佰傲再生医学有限公司 | 一种交联透明质酸凝胶微粒及其制备方法 |
CN105688284B (zh) * | 2014-09-29 | 2019-12-06 | 四川大学华西医院 | 一种仿细胞外基质可注射的原位水凝胶及其制备方法与应用 |
TWI716365B (zh) * | 2014-11-13 | 2021-01-21 | 德商梅茲製藥有限兩合公司 | 注射型真皮填充劑組合物及其套組、製備方法、與使用 |
US20160303281A1 (en) | 2015-04-17 | 2016-10-20 | Rochal Industries, Llc | Composition and kits for pseudoplastic microgel matrices |
CN104892962B (zh) * | 2015-06-05 | 2017-12-08 | 四川大学 | 一种巯基/二硫键可控自交联透明质酸水凝胶的制备方法及其应用 |
US10265439B2 (en) * | 2015-09-03 | 2019-04-23 | Arizona Board Of Regents On Behalf Of Arizona State University | Injectable cell-laden biohybrid hydrogels for cardiac regeneration and related applications |
WO2018058133A2 (en) * | 2016-09-26 | 2018-03-29 | Duke University | Compositions and systems for intracranial delivery, and methods of making and using the same |
CN107412861B (zh) * | 2017-02-24 | 2021-08-06 | 武汉采思生物科技有限公司 | 重组胶原蛋白复合硫酸软骨素和聚乙二醇的骨修复凝胶 |
JP7216006B2 (ja) | 2017-03-22 | 2023-01-31 | ジェネンテック, インコーポレイテッド | ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法 |
CN107540849A (zh) * | 2017-09-11 | 2018-01-05 | 常州百瑞吉生物医药有限公司 | 明胶化学改性方法及其交联材料和用途 |
CN107501577B (zh) * | 2017-09-21 | 2020-02-18 | 天津工业大学 | 一种可降解原位凝胶的制备方法 |
CN107583104B (zh) * | 2017-10-31 | 2020-12-01 | 无锡中科光远生物材料有限公司 | 一种可注射的用于脊柱修复的凝胶材料 |
CN110343264B (zh) * | 2018-04-03 | 2021-11-26 | 中国科学院苏州纳米技术与纳米仿生研究所 | 壳聚糖水凝胶及其制备方法与应用 |
CN112334166A (zh) * | 2018-06-15 | 2021-02-05 | 克罗马药品有限责任公司 | 包含交联聚合物的水凝胶组合物 |
WO2019238954A1 (en) * | 2018-06-15 | 2019-12-19 | Croma-Pharma Gmbh | Hydrogel composition comprising a crosslinked polymer |
WO2020050205A1 (ja) * | 2018-09-03 | 2020-03-12 | 富士フイルム株式会社 | ゲル形成キット、ゲルおよびゲルの製造方法 |
CA3060806A1 (en) | 2018-11-09 | 2020-05-09 | Winfield Solutions, Llc | Hydrogels as carriers of active ingredients and methods of producing thesame |
CA3060477A1 (en) * | 2018-11-09 | 2020-05-09 | Windfield Solutions, Llc | Hydrogels as rheology modifiers and methods of making the same |
CN111378149B (zh) * | 2018-12-30 | 2021-08-31 | 中国科学院沈阳自动化研究所 | 一种用于3d打印或原位注射的因子缓释中性凝胶系统及其制备方法 |
KR20210121147A (ko) | 2019-01-30 | 2021-10-07 | 보오슈 앤드 롬 인코포레이팃드 | 가교화 중합체 망상구조물 및 이의 용도 |
CN109749098B (zh) * | 2019-01-30 | 2021-05-18 | 福州大学 | 一种物理/化学双交联网络高强度明胶水凝胶及其制备方法 |
CN110464871A (zh) * | 2019-08-21 | 2019-11-19 | 南开大学 | 一种可注射水凝胶及其制备方法 |
CN110787325A (zh) * | 2019-09-21 | 2020-02-14 | 常州百瑞吉生物医药有限公司 | 用于预防腹(盆)腔术后组织粘连的二硫键交联透明质酸凝胶及其制备方法 |
WO2021065995A1 (ja) | 2019-10-01 | 2021-04-08 | 富士フイルム株式会社 | 粘膜下注入材キットおよび粘膜下注入用ゲル |
CN110812253A (zh) * | 2019-10-23 | 2020-02-21 | 常州百瑞吉生物医药有限公司 | 一种用于水光注射的透明质酸凝胶及其使用方法 |
CN110812270B (zh) * | 2019-10-23 | 2021-09-17 | 常州百瑞吉生物医药有限公司 | 一种用于水光注射的透明质酸凝胶组合物及其制备方法 |
CN111253607A (zh) * | 2020-01-19 | 2020-06-09 | 南京工业大学 | 用于软骨修复的可注射聚氨基酸水凝胶及其制备方法 |
GB202005141D0 (en) * | 2020-04-07 | 2020-05-20 | Jellagen Pty Ltd | Jellyfish collagen use |
US20210361570A1 (en) * | 2020-05-19 | 2021-11-25 | Mcmaster University | In situ gelling polysaccharide-based nanoparticle hydrogel compositions, and methods of use thereof |
CN111632198A (zh) * | 2020-06-24 | 2020-09-08 | 四川大学 | 一种自交联透明质酸和明胶复合水凝胶注射剂及其制备方法和应用 |
CN111704730B (zh) * | 2020-07-01 | 2023-03-03 | 王萌燕 | 一种胃内超吸水凝胶初品及其制备方法、胃内超吸水凝胶及其制备方法和减重组合物 |
KR102478594B1 (ko) * | 2020-09-28 | 2022-12-16 | 연세대학교 산학협력단 | 공중합체, 공중합체의 제조 방법, 및 상기 공중합체를 포함하는 산화환원 감응형 하이드로겔 |
CN112587724B (zh) * | 2020-12-02 | 2022-06-03 | 西安医学院 | 一种低溶胀率高分子医用水凝胶及其制备方法 |
CN114618010A (zh) * | 2020-12-09 | 2022-06-14 | 四川大学 | 一种具有多功能的角蛋白基水凝胶及其制备方法 |
CN112587475B (zh) * | 2020-12-18 | 2022-09-13 | 华熙生物科技股份有限公司 | 一种载药凝胶及其制备方法 |
CN114656652A (zh) * | 2020-12-23 | 2022-06-24 | 上海其胜生物制剂有限公司 | 一种低溶胀温敏性可注射壳聚糖基水凝胶制备方法 |
CN113354803B (zh) * | 2021-06-10 | 2022-08-12 | 沈阳药科大学 | 一种含醛基侧基的聚碳酸酯/聚乙二醇嵌段共聚物、可注射自修复水凝胶敷料及制备方法 |
CN115702952A (zh) * | 2021-08-10 | 2023-02-17 | 上海交通大学医学院附属第九人民医院 | 基于可注射型水凝胶支架材料构建的可注射骨及其应用 |
WO2023080853A1 (en) * | 2021-11-03 | 2023-05-11 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | Rheologically synovial fluid-like hydrogel formulations for using in intra-articular applications |
CN114177353B (zh) * | 2021-12-20 | 2022-11-29 | 诺一迈尔(山东)医学科技有限公司 | 一种可注射温敏性自固化骨修复材料及其制备方法 |
CN114478829B (zh) * | 2021-12-31 | 2023-07-28 | 常州百瑞吉生物医药有限公司 | 一种透明质酸交联活性材料组合物、制备方法及应用 |
CN114716581A (zh) * | 2022-03-25 | 2022-07-08 | 常州百瑞吉生物医药有限公司 | 一种多重改性透明质酸衍生物及其应用 |
CN114716580A (zh) * | 2022-03-25 | 2022-07-08 | 常州百瑞吉生物医药有限公司 | 一种多重改性透明质酸衍生物的制备方法 |
CN115716924A (zh) * | 2022-11-15 | 2023-02-28 | 西北农林科技大学 | 一种高分子水凝胶及其制备方法、应用 |
CN116474158B (zh) * | 2023-03-09 | 2024-03-22 | 天津大学 | 一种止血凝胶及其制备方法及其在动态止血中的应用 |
CN117180494B (zh) * | 2023-11-07 | 2024-01-23 | 四川大学 | 可减少纤维化瘢痕产生的可注射多糖水凝胶及其制备方法 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4582865A (en) | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
EP0185070A1 (zh) | 1984-06-08 | 1986-06-25 | Pharmacia Ab | |
US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
US6624245B2 (en) | 1999-04-16 | 2003-09-23 | Cohesion Technologies, Inc. | Rapid-gelling biocompatible polymer composition and associated methods of preparation and use |
WO2004037164A2 (en) | 2002-06-21 | 2004-05-06 | University Of Utah Research Foundation | Crosslinked compounds and methods of making and using thereof |
US6884788B2 (en) | 2001-02-22 | 2005-04-26 | Anika Therapeutics, Inc. | Thiol-modified hyaluronan |
WO2005056608A1 (en) | 2003-12-04 | 2005-06-23 | University Of Utah Research Foundation | Modified macromolecules and methods of making and using thereof |
US7196180B2 (en) | 1998-09-18 | 2007-03-27 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
CN101190891A (zh) | 2006-11-24 | 2008-06-04 | 上海百瑞吉生物医药有限公司 | 二酰肼化合物及其制备方法和用途 |
CN101200504A (zh) | 2006-12-11 | 2008-06-18 | 上海百瑞吉生物医药有限公司 | 高分子巯基化改性衍生物及其交联材料 |
WO2008098019A2 (en) | 2007-02-05 | 2008-08-14 | Carbylan Biosurgery, Inc. | Polymer formulations for delivery of bioactive agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6371984B1 (en) * | 1999-09-13 | 2002-04-16 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US8153156B2 (en) | 2002-11-13 | 2012-04-10 | The United States Of America As Represented By The Department Of Veteran Affairs | Hydrogel nanocompsites for ophthalmic applications |
WO2005023331A2 (en) * | 2003-09-04 | 2005-03-17 | The United States Of America As Represented By The Department Of Veterans Affairs | Hydrogel nanocompsites for ophthalmic applications |
EP1606009A2 (en) * | 2003-03-25 | 2005-12-21 | BioCure, Inc. | Hydrogel string medical device |
WO2006034128A2 (en) * | 2004-09-17 | 2006-03-30 | Angiotech Biomaterials Corporation | Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use |
KR100624456B1 (ko) * | 2004-12-31 | 2006-09-19 | 삼성에스디아이 주식회사 | 직접액체연료전지 및 그를 구비한 휴대용 전자 장치 |
US8828433B2 (en) | 2005-04-19 | 2014-09-09 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
AU2006266741B2 (en) * | 2005-07-06 | 2011-09-01 | Seikagaku Corporation | Drug-introduced photo-crosslinked hyaluronic acid derived gel |
JP5513893B2 (ja) | 2006-12-22 | 2014-06-04 | クローマ−ファルマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 組織増大用インプラント |
-
2008
- 2008-10-16 CN CN2008100438453A patent/CN101721349B/zh active Active
-
2009
- 2009-09-08 US US13/124,412 patent/US9220676B2/en active Active
- 2009-09-08 AU AU2009304472A patent/AU2009304472B2/en active Active
- 2009-09-08 EP EP09820182.5A patent/EP2353612B1/en active Active
- 2009-09-08 WO PCT/CN2009/001013 patent/WO2010043106A1/zh active Application Filing
- 2009-09-08 JP JP2011531327A patent/JP5657545B2/ja active Active
- 2009-09-08 CA CA2740136A patent/CA2740136C/en active Active
- 2009-09-08 ES ES09820182.5T patent/ES2664269T3/es active Active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0185070A1 (zh) | 1984-06-08 | 1986-06-25 | Pharmacia Ab | |
US4582865A (en) | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
US7196180B2 (en) | 1998-09-18 | 2007-03-27 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
US6624245B2 (en) | 1999-04-16 | 2003-09-23 | Cohesion Technologies, Inc. | Rapid-gelling biocompatible polymer composition and associated methods of preparation and use |
US6884788B2 (en) | 2001-02-22 | 2005-04-26 | Anika Therapeutics, Inc. | Thiol-modified hyaluronan |
WO2004037164A2 (en) | 2002-06-21 | 2004-05-06 | University Of Utah Research Foundation | Crosslinked compounds and methods of making and using thereof |
WO2005056608A1 (en) | 2003-12-04 | 2005-06-23 | University Of Utah Research Foundation | Modified macromolecules and methods of making and using thereof |
CN101190891A (zh) | 2006-11-24 | 2008-06-04 | 上海百瑞吉生物医药有限公司 | 二酰肼化合物及其制备方法和用途 |
CN101200504A (zh) | 2006-12-11 | 2008-06-18 | 上海百瑞吉生物医药有限公司 | 高分子巯基化改性衍生物及其交联材料 |
WO2008098019A2 (en) | 2007-02-05 | 2008-08-14 | Carbylan Biosurgery, Inc. | Polymer formulations for delivery of bioactive agents |
Non-Patent Citations (25)
Title |
---|
BENESCH ET AL., PROC NATL ACAD SCI USA, vol. 44, 1958, pages 848 |
CAPOZZI G., MODENA G.: "In The Chemistry of the Thiol Group Part II", 1974, WILEY, pages: 785 - 839 |
CAPOZZI, THE CHEMISTRY OF THE THIOL GROUP PART, vol. 11, 1974, pages 785 |
DRURY, BIOMATERIALS, vol. 24, 2003, pages 4337 |
GIANOLIO, BIOCONJUGATE CHEMICAL, vol. 16, 2005, pages 1512 |
KAFEDJIISKI ET AL., BIOSUBSTANCES, vol. 26, 2005, pages 819 |
KIRKER ET AL., BIOSUBSTANCES, vol. 23, 2002, pages 3661 |
KUJAWA, DEVELOP BIOL, vol. 114, 1986, pages 519 |
LIU ET AL., JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 68, 2004, pages 142 |
LIU YANCHUN ET AL.: "Biocompatibility and stability of disulfide-crosslinked hyaluronan films.", BIOMATERIALS, vol. 26, 2005, pages 4737 - 4746, XP027768277 * |
LIU, JOURNAL OF BIOMEDICAL SUBSTANCES RESEARCH, vol. 68, 2004, pages 142 |
LUTOLF, NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 47 |
NICOLAS ET AL., BIOSUBSTANCES, vol. 8, 1997, pages 807 |
OSSIPOV, MAXROMOLECULES, vol. 41, 2008, pages 3971 |
See also references of EP2353612A4 * |
SHU ET AL., BIOMACROMOLECULES, vol. 3, 2002, pages 1304 |
SHU ET AL., BIOMACRO-MOLECULES, vol. 3, 2002, pages 1304 |
SHU ET AL., BIOMATERIALS, vol. 24, 2003, pages 3825 |
SHU XIAOZHENG ET AL.: "Disulfide Cross-Linked Hyaluronan Hydrogels.", BIOMACROMOLECULES., vol. 3, 2002, pages 1304 - 1311, XP055005444 * |
SHU XIAOZHENG ET AL.: "Disulfide-crosslinked hyaluronan-gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth.", BIOMATERIALS, vol. 24, 2003, pages 3825 - 3834, XP004431163 * |
SHU, BIOMACROMOLECULES, vol. 3, 2002, pages 1304 |
SHU, BIOMATERIALS, vol. 24, 2003, pages 3825 |
SHU, BIOSUBSTANCES, vol. 24, 2003, pages 3825 |
SILVA, CURR TOP DEV BIOL, vol. 64, 2004, pages 181 |
YAMAUCHI, BIOSUBSTANCES, vol. 22, 2001, pages 855 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9446067B2 (en) | 2010-09-09 | 2016-09-20 | Bioregen Biomedical (Changzhou) Co. Ltd. | Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof |
US10064889B2 (en) | 2010-09-09 | 2018-09-04 | Bioregen Biomedical (Changzhou) Co., Ltd. | Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof |
WO2013021249A1 (en) * | 2011-08-10 | 2013-02-14 | Glycores 2000 S.R.L. | Degradation-resistant cross-linked, low-molecular-weight hyaluronate |
Also Published As
Publication number | Publication date |
---|---|
JP5657545B2 (ja) | 2015-01-21 |
AU2009304472B2 (en) | 2016-03-03 |
CN101721349A (zh) | 2010-06-09 |
CN101721349B (zh) | 2011-07-20 |
US20120034271A1 (en) | 2012-02-09 |
CA2740136A1 (en) | 2010-04-22 |
ES2664269T3 (es) | 2018-04-18 |
AU2009304472A1 (en) | 2010-04-22 |
EP2353612B1 (en) | 2018-01-03 |
JP2012505840A (ja) | 2012-03-08 |
EP2353612A1 (en) | 2011-08-10 |
US9220676B2 (en) | 2015-12-29 |
EP2353612A4 (en) | 2012-05-09 |
CA2740136C (en) | 2015-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2010043106A1 (zh) | 可注射原位交联水凝胶及其制备方法和用途 | |
US10064889B2 (en) | Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof | |
US11065365B2 (en) | Preparation and/or formulation of proteins cross-linked with polysaccharides | |
Sultana et al. | TEMPO oxidized nano-cellulose containing thermo-responsive injectable hydrogel for post-surgical peritoneal tissue adhesion prevention | |
AU2008296975B2 (en) | Delayed self-gelling alginate systems and uses thereof | |
JP5489999B2 (ja) | 外科用ハイドロゲル | |
EP1799232B1 (en) | Self-gelling alginate systems and uses thereof | |
WO2009006780A1 (fr) | Procédé pour la formation d'un hydrogel biocompatible à gélification rapide et préparation d'un agent de pulvérisation | |
KR102280553B1 (ko) | 개선된 하이드로젤 지혈제 제조방법 및 그에 따른 지혈제 | |
Cassano et al. | Polysaccharides and proteins-based hydrogels for tissue engineering applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09820182 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2740136 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011531327 Country of ref document: JP Ref document number: 13124412 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 3137/DELNP/2011 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009304472 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009820182 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2009304472 Country of ref document: AU Date of ref document: 20090908 Kind code of ref document: A |