WO2009151048A1 - 飼料用組成物およびそれを含有する飼料 - Google Patents
飼料用組成物およびそれを含有する飼料 Download PDFInfo
- Publication number
- WO2009151048A1 WO2009151048A1 PCT/JP2009/060519 JP2009060519W WO2009151048A1 WO 2009151048 A1 WO2009151048 A1 WO 2009151048A1 JP 2009060519 W JP2009060519 W JP 2009060519W WO 2009151048 A1 WO2009151048 A1 WO 2009151048A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- feed
- oil
- cashew nut
- nut shell
- feed composition
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Definitions
- the present invention relates to a feed composition containing cashew nut shell liquid (CNSL) and / or anacardic acids and an oil-absorbing agent, a feed, and a method for breeding ruminants using the same.
- the present invention also relates to a feed composition containing a crushed cashew nut shell and an oil absorbent, a feed, and a method for raising ruminants using the same.
- Ruminants such as cattle and sheep live in the rumen by digesting and fermenting feed with microorganisms and using the fermented products. Therefore, methane generation from rumen results in a loss of feed energy efficiency. Furthermore, since methane is a warming gas that affects global warming, it is important to reduce methane production in ruminant rumen. Methanogens in the rumen use hydrogen to reduce carbon dioxide and produce methane. The contribution rate of methane to global warming is the second highest after carbon dioxide, and methane released from ruminants accounts for 15-20% of total methane emissions.
- Antiophores such as monensin, an antibiotic, are widely used in ruminant feed.
- Monensin has a selective inhibitory effect on rumen microorganisms, and as a result, has a function of reducing methane production and promoting propionic acid production.
- Propionic acid has higher ATP production efficiency than other volatile fatty acids, and feed efficiency is improved by promoting the production of propionic acid.
- Non-patent document 1 plant extract oil
- Non-patent document 2 anti-lactic acid-producing bacteria vaccine
- Non-patent document 3 anti-lactic acid-producing bacteria egg antibody
- Staphylococcus aureus is the causative agent of cattle, sheep, goat mastitis, subcutaneous tumors, abscess, equine rash, swine, chicken arthritis, dermatitis, sepsis.
- Streptococcus suis ( Streptococcus suis ) is a causative agent of swine meningitis, sepsis, endocarditis and arthritis
- Streptococcus bovis is a causative agent of bovine bloating disease.
- Pylosis is a condition in which the gastric fluid does not separate due to foaming of the rumen contents, and the accumulated gas can no longer be discharged out of air, compressing the heart and lungs and dying if left as it is It will end up.
- a large amount of starch and a large amount of starch, such as corn Streptococcus bovis increases in the rumen, and the rumen fluid becomes foamy due to the viscous material produced.
- Non-patent Document 4 Cashew nut shell liquid is known to have an antibacterial action (Non-patent Document 4) and a coccidiosis-reducing action (Patent Document 2).
- Patent Document 6 test tube test results using anacardic acid (Non-Patent Document 6) have been reported, reproducibility in actual animals, application, and optimal content There is no disclosure.
- cashew nut shell liquid is Staphylococcos aureus, Streptococcus mutans, Bacillus subtilis , there is antibacterial activity on Gram-positive bacteria such as Bacillus ammoniagenes, Escherichia coli, Enterobacter aerogenes , Gram-negative bacteria and Saccharomyces cerevisiae, such as Pseudomonas aeruginosa, Candida utilis, It has been reported that fungi such as Penichillium chrysogenum have no antibacterial action (Non-patent Document 5), but the antibacterial action of cashew nut shell liquid against S. bovis is not known, and there is a report on the prevention of bloating disease. Not at all.
- the crushed cashew nut shell is also in a jelly form, and it is necessary to prepare a formulation that can be uniformly mixed with feed.
- the present invention improves the rumen fermentation of ruminants and the like, contributes to the suppression of the generation of global warming gas, and can further suppress bloating, which is a problem in ruminants, and / or cashew nut shell liquid (CNSL) and / or It is an object to formulate anacardic acids or cashew nut shell pulverized products into easy-to-handle powders. Another object is to prevent rash caused by cashew nut shell liquid.
- the inventors of the present invention consisted of cashew nut shell liquid and / or anacardic acids and an oil-absorbing agent, and the cashew nut shell liquid and / or anacardic acids are based on the total amount of the composition for feed. It has been found that a feed composition characterized by containing 25 mass% to 65 mass% can be formulated into a powder that is easy to handle.
- the present inventors also comprise a feed composition comprising a crushed cashew nut shell and an oil-absorbing agent, the crushed cashew nut shell being contained in an amount of 10% to 90% by weight based on the total amount of the feed composition. However, it has been found that it can be formulated into a powder that is easy to handle.
- the present inventors comprise cashew nut shell liquid and / or anacardic acids, an oil-absorbing agent, and a hardened oil, and contain 25% to 65% by weight of the cashew nut shell liquid and / or anacardic acids based on the total amount of the feed composition. It has been found that a feed composition characterized by the above can be formulated into a powder that is easy to handle.
- the present inventors also comprise a feed comprising the crushed cashew nut shell, an oil-absorbing agent, and a hardened oil, the crushed cashew nut shell containing 10% by weight to 90% by weight based on the total amount of the feed composition. It has been found that the composition can be formulated into a powder that is easy to handle. The inventors have thus completed the present invention.
- the present invention is as follows.
- Powder comprising cashew nut shell liquid and / or anacardic acids and an oil-absorbing agent, and containing 25% to 65% by weight of the cashew nut shell liquid and / or anacardic acids based on the total amount of the composition for feed Granular feed composition.
- a powdery feed composition comprising a cashew nut shell pulverized product and an oil absorbent, wherein the cashew nut shell pulverized product is contained in an amount of 10% by mass to 90% by mass based on the total amount of the feed composition.
- a method for raising livestock comprising feeding the feed according to any one of (7) to (9).
- (11) Use of cashew nut shell liquid and / or anacardic acids and an oil-absorbing agent for producing a granular feed composition.
- (12) A method for treating livestock, comprising administering cashew nut shell liquid and / or anacardic acids and an oil-absorbing agent.
- Cashew nut shell oil and / or anacardic acid or cashew nut shell pulverized product is mixed with an oil absorbent and processed into a powder that is easy to handle and does not touch hands, and if necessary, processed into granules such as pellets By doing so, the composition for feed becomes easy to be mixed with feed and safe for the user.
- FIG. 1 shows the back of a rabbit that has been subjected to pretreatment for hair shaving and hair removal and is provided with four application sites.
- the feed composition of the present invention comprises cashew nut shell liquid and / or anacardic acids and an oil-absorbing agent, and contains 25% to 65% by weight of the cashew nut shell oil and / or anacardic acids based on the total amount of the feed composition. It is characterized by.
- the feed composition of the present invention also comprises a cashew nut shell pulverized product and an oil absorbent, and is characterized in that the cashew nut shell crushed product is contained in an amount of 10% by mass to 90% by mass based on the total amount of the feed composition.
- the cashew nut shell liquid used in the present invention is an oily liquid contained in the shell of the cashew nut tree ( Anacardium occidentale L.).
- Cashew nut shell oil contains anacardic acid, cardanol, and cardol as its components.
- the cashew nut shell oil used in the present invention can be obtained as a vegetable oil extracted by pressing the cashew nut shell. Heated cashew nut shell oil obtained by heating the non-heated cashew nut shell oil obtained as described above to 70 ° C. or higher, preferably 130 ° C. or higher may be used.
- the cashew nut shell oil used in the present invention can also be obtained by, for example, dry distillation or solvent extraction of the cashew nut shell by heating or extraction. Further, the cashew nut shell oil used in the present invention is charged into the heated cashew nut shell oil heated to 200 to 240 ° C. by the method described in JP-A-8-231410. It can be obtained by extracting heated cashew nut shell oil.
- the heated cashew nut shell liquid can also use a heated commercial product.
- the cashew nut shell oil used in the present invention may be obtained by crushing and crushing cashew nut shells.
- a commercial item can also be used for the cashew nut shell liquid used in this invention.
- the content of cashew nut shell liquid in the feed composition of the present invention is preferably 25% by mass to 65% by mass based on the total amount of the feed composition. If it is 25% by mass or more, the effect of improving rumen fermentation can be efficiently achieved, and if it is 65% by mass or less, hand irritation is eliminated and workability of the improver can be maintained.
- the content of the cashew nut shell pulverized product in the feed composition of the present invention is preferably 10% by mass to 90% by mass. If it is 10% by mass or more, the effect of improving rumen fermentation can be efficiently achieved, and if it is 90% by mass or less, the hand irritation is eliminated and the handling of the improver can be maintained.
- the content of cashew nut shell liquid and / or anacardic acids in the feed of the present invention is preferably 0.02% by mass to 4.0% by mass, more preferably 0.04% by mass to 2.0% by mass, and still more preferably. Is 0.06% by mass to 1.0% by mass. If it is 0.02 mass% or more, the effect of improving rumen fermentation can be efficiently achieved, and if it is 4.0 mass% or less, handleability can be maintained, which is preferable.
- the cashew nut shell oil used in the present invention may be used after being crushed and crushed, but converted into the cashew nut shell oil (CNSL) contained therein (the cashew nut shell contains 30% CNSL).
- the feed composition and the feed content may be within the above ranges.
- anacardic acids used in the present invention include natural products anacardic acid, synthetic anacardic acid, and derivatives thereof. Commercial anacardic acid may also be used.
- anacardic acids are obtained by using cashew nut oil obtained by extracting cashew nut shells with an organic solvent by using, for example, silica gel column chromatography with n-hexane, acetic acid. It can be obtained by changing the ratio of the mixed solvent of ethyl and acetic acid (JP-A-3-240721, JP-A-3-240716, etc.).
- Such anacardic acids can be contained in feed compositions and feeds with the same content as cashew nut shell liquid.
- oil-absorbing agent contained in the feed composition of the present invention examples include magnesium oxide, stearate, talc, zeolite, diatomaceous earth, and silica, and particulate ones are preferred.
- the oil absorbing agent of the present invention is preferably an oil absorbing agent that adsorbs 50 to 300 g of oil per 100 g. Further, when the particle size exceeds 200 ⁇ m, the particles become coarse and separate, so that the particle size is preferably 2 to 200 ⁇ m.
- the preferred mass ratio between the oil-absorbing agent and cashew nut oil is 100: 20 to 100: 180.
- a preferable mass ratio in the case of the oil absorbing agent and the cashew nut shell pulverized product is 15: 100 to 60: 100.
- the dosage form of the feed composition of the present invention can be formulated as a powder by containing an oil absorbent such as silica. That is, the feed composition of the present invention can be produced by mixing cashew nut shell liquid, an oil absorbing agent, and optional components as necessary, and formulating it into a powder. Such a powdery composition for feed according to the present invention can be used as a composition for feed and further as a feed without being mixed with other optional components.
- the composition for feed of the present invention can be made into granules such as pellets in addition to powder.
- granules such as pellets in addition to powder.
- an oil absorbent to CNSL in addition to adding an oil absorbent to CNSL, add hardened oil.
- the hardened oil oil obtained by hardening palm oil, soybean oil, rapeseed oil or the like is used.
- the melting point of the hardened oil is preferably 45 to 65 ° C.
- it can manufacture using a normal extrusion granulator.
- a preferred mass ratio of the oil-absorbing agent, cashew nut oil, and hardened oil is 80 to 120: 60 to 100: 80 to 120, and the oil absorbing agent, cashew nut shell pulverized product, A preferred mass ratio with the hardened oil is 15 to 45:60 to 100: 80 to 120.
- dosage form of the composition for feed “powder”, “granular (pellet)”, and “powder” refer to the state of smoothness that does not solidify even with a strong hand grip. . In this state, most of the CNSL is adsorbed inside the oil absorbent such as silica and is hardly exposed on the surface of the carrier.
- the composition for feed of this invention can be used in order to control bloating.
- it since it exhibits antibacterial activity against Streptococcus bovis , it can be used to control bloating caused by Streptococcus bovis .
- control includes prevention and treatment.
- composition for feed of the present invention is an optional component such as a cashew nut shell liquid and / or an anacardic acid and an oil-absorbing agent, an ingredient effective for promoting the growth of ruminants, a nutritional supplement, and a component that enhances storage stability. May further be included.
- optional components include live bacteria such as Enterococcus bacteria, Bacillus bacteria, and Bifidobacteria; enzymes such as amylase and lipase; vitamins such as L-ascorbic acid, choline chloride, inositol, and folic acid; potassium chloride , Minerals such as iron citrate, magnesium oxide, phosphates, amino acids such as DL-alanine, DL-methionine, L-lysine; organic acids such as fumaric acid, butyric acid, lactic acid, acetic acid and their salts; ethoxyquin, dibutyl Antioxidants such as hydroxytoluene, butylhydroxyanisole, ferulic acid, vitamin C, and vitamin E; fungicides such as calcium propionate; binders such as CMC, sodium caseinate, sodium polyacrylate; lecithin, glycerin fatty acid ester , Emulsifiers such as sorbitan fatty acid ester; Tri
- composition for feed of the present invention is suitably used as a rumen fermentation improving agent for ruminants and also as a bloating control agent.
- control refers to prevention and / or treatment.
- the composition for feed of this invention can be mixed with the other feed component used for normal feed, and can be made into feed.
- the type of feed and ingredients other than cashew nut shell liquid are not particularly limited.
- the feed is preferably for ruminants.
- the content of cashew nut shell liquid and / or anacardic acids in the feed of the present invention is 0.5 to 50,000 mass ppm, preferably 5 to 10,000 mass ppm, more preferably from the viewpoint of effect and cost per dry matter amount of the feed. 50 to 5,000 ppm by mass.
- the feed of the present invention can be produced by adding the feed composition directly to the feed ingredients and mixing them.
- the feed composition may be in a liquid or gel form to facilitate mixing.
- water, vegetable oils such as soybean oil, rapeseed oil and corn oil, liquid animal oils, water-soluble polymer compounds such as polyvinyl alcohol, polyvinyl pyrrolidone and polyacrylic acid can be used as the liquid carrier.
- a water-soluble polysaccharide such as alginic acid, sodium alginate, xanthan gum, sodium caseinate, gum arabic, guar gum, tamarind seed polysaccharide.
- the feed of the present invention is suitable for breeding ruminants such as cows, goats and sheep.
- the amount of feed to be ingested can be appropriately adjusted according to the kind of animal, body weight, age, sex, health condition, ingredients of the feed, etc., and cashew nut nut shell oil and / or anacardic acids contained in the feed are preferable.
- a method for ingesting and rearing a feed a commonly used method can be employed depending on the type of animal.
- Example 1 Powdered feed composition consisting of CNSL and oil-absorbing agent (1)
- Prototype preparation Cashew nut shells are obtained from Cashew Trading Co., Ltd., and cashew nut shell oil (CNSL) is extracted by pressing and used for the following tests did.
- the composition of CNSL was measured by the following method. That is, HPLC (Waters 600, Nippon Waters Co., Ltd.), detector (Waters 490E, Nihon Waters Co., Ltd.), printer (Chromatopack C-R6A, Shimadzu Corporation), column (SUPELCOSIL LC18, SUPELCO) were used.
- a solvent of acetonitrile: water: acetic acid of 80: 20: 1 (dose ratio) was used, and the flow rate was 2 ml / min. Detection was performed at an absorbance of 280 nm.
- the cashew nut shell liquid contained 61.8% by mass of anacardic acid, 8.2% by mass of cardanol, and 19.9% by mass of cardol.
- CNSL is a liquid or solid at room temperature, and is difficult to remove when attached to human skin, causing rash.
- the primary irritation rate is calculated by dividing the sum of the scores at the non-abraded and abraded sites 24 and 72 hours after removal of the test substance by 4.
- the skin primary irritation index was 0, it was defined as “no irritation”, “mild” when greater than 0 and less than 2, “medium” when 2 or more and less than 5, and “strength” when 5 or more.
- the test was conducted with 6 animals per group, and the results are shown in Table 2.
- Example 2 Powdered feed composition comprising crushed cashew nut shell and oil-absorbing agent
- Trial preparation Cashew nut shell was obtained from Cashew Trading Co., Ltd. and subjected to the following tests.
- Cashew nut shells and silica (trade name Siprnat 22, product of Degussa) were uniformly pulverized with a pulverizer (Oster Blender, product of Aswan) to prepare a powdery feed composition. The results are shown in Table 3.
- test agents of Comparative Examples 1-3 and 1-4 showed mild to strong irritation.
- the test agents of Experimental Examples 1-4 and 1-5 were not irritating. CNSL was adsorbed inside the silica, and the irritation was suppressed in the state of a smooth powder, but the test agents of Comparative Examples 1-3 and 1-4 in which CNSL was not adsorbed showed irritation.
- Example 3 To examine the antibacterial action against S. bovis antimicrobial action CNSL against S. bovis antimicrobial action CNSL against S. bovis in CNSL, Staphylococcos aureus bovine isolates, S. bovis DSM20065 strain, Bacillus subtilis NBRC3009 strain, Escherichia coli ATCC11303 strain, Pseudomonas aeruginosa NBRC12689 strain, and Saccharomyces cerevisiae The NBRC10217 strain was cultured at 37 ° C. for 1 day in a brain heart infusion medium (product of Nissui Pharmaceutical Co., Ltd.). 10 ⁇ L of the inoculated brain heart infusion medium supplemented with CNSL was inoculated and cultured at 37 ° C. for 2 days to calculate the minimum inhibitory concentration (MIC). The results are shown in Table 5.
- CNSL has a high antibacterial activity against S. bovis as well as the Gram-positive bacteria Staphylococcos aureus and Bacillus subtilis . Therefore, it turns out that the powder containing CNSL has the effect which prevents bloating.
- the pH of the rumen solution did not decrease during the administration of the test agents of Experimental Examples 1-1 and 1-5, but decreased when the administration of the test agent of Experimental Examples 1-5 was stopped. It can be seen that the test agents of Experimental Examples 1-1 and 1-5 have the effect of preventing the pH of the rumen solution from being lowered. That is, it can be seen that the test agents of Experimental Examples 1-1 and 1-5 have the effect of preventing rumen acidosis that causes rumen liquid to be acidified and deteriorate the rumen function.
- Table 7 shows the viscosity (CP) of the rumen liquid, the foamability (IVI (%)) and the foam stability (sIVI (%)) of the rumen liquid.
- Bovine bloating is a disease in which the rumen fluid becomes foamy and can no longer feel good, causing gas to accumulate in the lumen and bloating the abdomen. In severe cases, the heart and lungs are compressed, leading to death.
- the viscosity, foamability, and foam stability of the rumen solution were all decreased by administration of the test agents of Experimental Examples 1-1 and 1-5, and increased when the administration was stopped. That is, it can be seen that the test agents of Experimental Examples 1-1 and 1-5 have an effect of preventing bloating.
- Table 8 shows the amount of gas (ml / day / tube) produced when the collected rumen solution was sealed in a test tube and cultured at 37 ° C. for 24 hours.
- the total VFA concentration did not change even when the test agents of Experimental Examples 1-1 and 1-5 were added (the fermentation itself was not suppressed). Furthermore, by adding the test agents of Experimental Examples 1-1 and 1-5, the fermentation pattern changed significantly, acetic acid production was significantly reduced, and propionic acid production was significantly increased. That is, the lumen function improvement effect was recognized.
- Table 10 shows the ammonia concentration (mgN / dl) in the collected rumen fluid.
- Embodiment 5 FIG. Granule (pellet-shaped) feed composition consisting of CNSL, oil absorbent and hydrogenated oil
- Trial preparation Palm extremely hardened oil (trade name: PW-50, product of Yokoseki Oil & Fat Co., Ltd., melting point 50 ° C.) 60
- silica (trade name Siprnat22, a product of Degussa) is added and mixed well, and disk pelleter F-5 type ((stock) ) Technopowder Dalton product).
- pretreatment for hair shaving and hair removal was performed on the back, and four application sites were provided. Of these, the stratum corneum was peeled off at two locations to obtain a scratched site. Lint cloth (1 x 1 inch) so that the mixture of silica and CNSL contained in the pellets wetted and disintegrated with pharmacopoeia water is 0.5 g in each of the non-abrasion and the abrasion area (2 areas in total) And evenly applied to the back. 0.5 ml of purified pharmacopoeia water as a control was applied in the same manner to each of the remaining 1 place (2 places in total). The application time was 4 hours.
- the primary stimulation rate is calculated by dividing the sum of the scores at the non-abraded and abraded sites 24 and 72 hours after removal of the test substance by 4.
- the skin primary irritation index was 0, it was defined as “no irritation”, “mild” when greater than 0 and less than 2, “medium” when 2 or more and less than 5, and “strength” when 5 or more.
- the test was conducted with 6 animals per group, and the results are shown in Table 13.
- the test agent of Comparative Example 2-4 showed strong irritation because CNSL directly touched the skin, whereas the test agents of Comparative Examples 2-2 and 2-3 showed mild irritation. In contrast, the test agents of Experimental Examples 2-1 to 3 were not irritating. In the hard pellet, CNSL is adsorbed on the silica inside the pellet and the irritation is suppressed, but the test agents of Comparative Examples 2-2 and 2-3 in which CNSL cannot be adsorbed inside the silica showed irritation. . The irritation was also suppressed by the test agent of Comparative Example 2-5.
- Example 6 Granulated (pellet-shaped) feed composition consisting of crushed cashew nut shell, oil absorbent and hydrogenated oil
- a grinder Oled Blender, ASONE
- the pulverized product was added with palm extremely hardened oil previously dissolved, mixed well, and granulated using a disk pelleter F-5 type (Techno-Paul Dalton product). The results are shown in Table 15.
- test agents of Comparative Examples 2-6 and 2-7 showed mild to strong irritation.
- the test agents of Experimental Examples 2-4 and 2-5 were not irritating. CNSL is adsorbed inside the silica, and the irritation is suppressed in the hard pellet state, but the test agent of Comparative Example 2-6 in which CNSL is not adsorbed showed irritation.
- the pH of the rumen solution decreased during the administration of the test agent of Comparative Example 2-5, but was recovered by administering the test agent of Experimental Example 2-2. However, it decreased when administration of the test agent in Experimental Example 2-2 was stopped.
- the test agent of Experimental Example 2-2 has an effect of preventing the pH of the rumen solution from being lowered
- the test agent of Comparative Example 2-5 which was heat-treated at the time of manufacture, has no effect of preventing the pH of the rumen solution from being lowered. I understand. That is, it can be seen that the test agent of Experimental Example 2-2 has an effect of preventing rumen acidosis that causes rumen liquid to be acidified and deteriorate the lumen function.
- Table 18 shows the viscosity (CP) of the rumen liquid, the foamability (IVI (%)) and the foam stability (sIVI (%)) of the rumen liquid.
- Bovine bloating is a disease in which the rumen fluid becomes foamy and can no longer feel good, causing gas to accumulate in the lumen and bloating the abdomen. In severe cases, the heart and lungs are compressed, leading to death. The viscosity, foamability, and foam stability of the rumen fluid all decreased with the administration of the test agent of Experimental Example 2-2, and increased when the administration was stopped. That is, it can be seen that the test agent of Experimental Example 2-2 has an effect of preventing bloating. The effect of preventing bloating was not observed in the test agent of Comparative Example 2-5, which was heat-treated at the time of manufacture. Table 19 shows the amount of gas (ml / day / tube) produced when the collected rumen solution was sealed in a test tube and cultured at 37 ° C. for 24 hours.
- Test agent in Experimental Example 2-2 significantly reduced methane. It is considered that the hydrogen produced by anaerobic fermentation is smoothly transferred to an alternative hydrogen consumption system because there is no accumulation of hydrogen associated with methane reduction.
- the test agent of Comparative Example 2-5 which was heat-treated at the time of manufacture, did not show the effect of preventing methane generation.
- Table 20 shows the total VFA concentration (mmol / dl), acetic acid molar ratio (%), propionic acid molar ratio (%), and butyric acid molar ratio (%) in the collected rumen fluid.
- the total VFA concentration did not change even when the test agent of Experimental Example 2-2 was added (the fermentation itself was not suppressed). Furthermore, the fermentation pattern was remarkably changed by adding the test agent of Experimental Example 2-2, acetic acid production was significantly reduced, and propionic acid production was significantly increased. That is, the lumen function improvement effect was recognized.
- the test agent of Comparative Example 2-5 which was heat-treated at the time of manufacture, did not show the effect of improving the lumen function.
- Table 21 shows the ammonia concentration (mgN / dl) in the collected rumen fluid.
- methane is a loss of feed energy and a greenhouse gas
- reducing methane from cattle is an urgent issue in both animal husbandry and environment, but feeds ruminants with cashew nut shell oil.
- methane production can be suppressed.
- Propionic acid has the highest conversion efficiency of feed hexose energy among volatile fatty acids, and is a glycogen that replaces glucose after absorption. Therefore, by promoting the production of propionic acid, other glycogens (such as amino acids) ) Leads to savings.
- the feed containing cashew nut shell liquid can enhance the energy and protein utilization efficiency of livestock.
- bloating can be controlled by feeding ruminants with cashew nut shell liquid.
- the feed composition of the present invention can be processed into a powder or a granule to eliminate the drawback that CNSL is sticky with a viscous liquid and difficult to mix with the bait, and can improve handling properties. .
- the CNSL stock solution does not come off when it adheres to the skin, but by adsorbing to the silica, the oil does not come into contact with the skin and the rash can be prevented.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
ルーメン内のメタン生成菌は水素を利用して二酸化炭素を還元してメタンを生成している。メタンの温暖化に対する寄与率は二酸化炭素に次いで高く、総メタン放出量のうち、反芻動物から放出されるメタンは15~20%を占めるとされる。
抗生物質は、(1)家畜の病原菌感染の予防、(2)代謝の改善、(3)腸内の有害菌の増殖抑制などの効果により成長促進作用を表すとされているが、詳細は依然不明である。その一方、飼料に抗生物質を混ぜることにより結果として抗生物質を広く環境にばら撒くこととなり、そのため発生する抗生物質耐性菌の出現が社会問題となっている。近年、抗生物質の飼料への添加が厳しく規制されるようになってきており、欧州では2006年1月までに成長促進を目的とした抗生物質の使用が禁止されている。また、生産者からも抗生物質を使用しない畜産物に対する要望は強く、抗生物質の代替物のニーズは大きくなってきている。
鼓脹症は第一胃内容液が泡沫状になることでガスと液が分離しなくなり、たまったガスをあい気で外に出せなくなった状態であり、心臓と肺を圧迫し、そのままだと死んでしまう。粗飼料が少なく、トウモロコシなどのデンプン質の多く含まれるエサを与えると、ルーメン内でStreptococcus bovisが増え、産生された粘性物質のためルーメン液が泡沫状になる。
また、カシューナッツ殻油がStaphylococcos aureus、Streptococcus mutans、Bacillus subtilis、Bacillus ammoniagenesのようなグラム陽性菌に抗菌作用があり、Escherichia coli、Enterobacter aerogenes、Pseudomonas aeruginosaのようなグラム陰性菌およびSaccharomyces cerevisiae、Candida utilis、Penichillium chrysogenumのような真菌に抗菌作用が無いことが報告されているが(非特許文献5)、カシューナッツ殻油のS. bovisに対する抗菌作用は知られておらず、鼓脹症予防効果に関しては報告が全く無い。
前記カシューナッツ殻油は室温で液体から固体のため、飼料に均一に混和する事は困難であり製剤化する必要性がある。また、カシューナッツ殻粉砕物もゼリー状であり、飼料に均一に混和できる製剤化が必要である。
本発明者らはまた、カシューナッツの殻粉砕物と吸油剤からなり、前記カシューナッツ殻粉砕物を飼料用組成物全量基準で10質量%~90質量%含有することを特徴とする、飼料用組成物が、取り扱いやすい粉粒状に製剤化できることを見出した。
本発明者らは、カシューナッツ殻油及び/又はアナカルド酸類と吸油剤と硬化油からなり、前記カシューナッツ殻油及び/又はアナカルド酸類を飼料用組成物全量基準で25質量%~65質量%含有することを特徴とする、飼料用組成物が、取り扱いやすい粉粒状に製剤化できることを見出した。
本発明者らはまた、カシューナッツの殻粉砕物と吸油剤と硬化油からなり、前記カシューナッツ殻粉砕物を飼料用組成物全量基準で10質量%~90質量%含有することを特徴とする、飼料用組成物が、取り扱いやすい粉粒状に製剤化できることを見出した。
本発明者らは、このようにして、本発明を完成するに至った。
(1)カシューナッツ殻油及び/又はアナカルド酸類と吸油剤からなり、前記カシューナッツ殻油及び/又はアナカルド酸類を飼料用組成物全量基準で25質量%~65質量%含有することを特徴とする、粉粒状の飼料用組成物。
(2)カシューナッツの殻粉砕物と吸油剤からなり、前記カシューナッツ殻粉砕物を飼料用組成物全量基準で10質量%~90質量%含有することを特徴とする、粉粒状の飼料用組成物。
(3)前記吸油剤が酸化マグネシウム、ステアリン酸塩、タルクおよびシリカの群から選ばれる1種以上であることを特徴とする、(1)又は(2)記載の粉粒状の飼料用組成物。
(4)前記吸油剤が100g当たり50~300gの油を吸着する吸油剤である、(3)記載の粉粒状の飼料用組成物。
(5)前記吸油剤が粒径2~200μmの粒子であることを特徴とする、(4)に記載の粉粒状の飼料用組成物。
(6)さらに硬化油を含む、(1)~(5)のいずれか1項に記載の粉粒状の飼料用組成物。
(7)(1)~(6)のいずれか1項に記載の飼料用組成物を含むことを特徴とする、飼料。
(8)前記カシューナッツ殻油を飼料全量基準で0.02~4.0質量%含有することを特徴とする(7)記載の飼料。
(9)反芻動物用である、(7)又は(8)記載の飼料。
(10)(7)~(9)のいずれか1項記載の飼料を摂取させることを特徴とする家畜の飼育方法。
(11)粉粒状の飼料用組成物を製造するための、カシューナッツ殻油及び/又はアナカルド酸類と吸油剤の使用。
(12)カシューナッツ殻油及び/又はアナカルド酸類と吸油剤を投与することを特徴とする家畜の治療方法。
本発明の飼料用組成物はまた、カシューナッツの殻粉砕物と吸油剤からなり、前記カシューナッツ殻粉砕物を飼料用組成物全量基準で10質量%~90質量%含有することを特徴とする。
また、本発明において使用されるカシューナッツ殻油は、加熱または抽出により、例えば、カシューナッツ殻を乾留又は溶剤抽出して得ることもできる。さらに、本発明において使用されるカシューナッツ殻油は、特開平8-231410号公報に記載されている方法によって、詳細には、200~240℃に加熱した加熱カシューナッツ殻油にカシューナッツの殻を投入し、加熱カシューナッツ殻油を抽出することによって得ることができる。また、加熱カシューナッツ殻油は、加熱済の市販品を用いることもできる。
本発明において使用されるカシューナッツ殻油は、カシューナッツの殻を粉砕・破砕して得られたものであってもよい。
本発明において使用されるカシューナッツ殻油は、市販品を用いることもできる。
また、カシューナッツの殻粉砕物と吸油剤の粉剤を用いる場合には、本発明の飼料用組成物におけるカシューナッツ殻粉砕物の含有量は、好ましくは10質量%~90質量%である。10質量%以上であればルーメン発酵改善効果を効率的に奏することができ、90質量%以下であれば作業上、手のかぶれが解消され、改善剤の取扱性を維持することができるので好ましい。
本発明において使用されるカシューナッツ殻油は、これを粉砕・破砕して用いてもよいが、含有しているカシューナッツ殻油(CNSL)に換算して(カシューナッツ殻にはCNSLが30%含まれている)、飼料用組成物、飼料中の含有量を上記範囲内とすればよい。
本発明の飼料用組成物において、吸油剤とカシューナッツ油の好ましい質量比は、100:20~100:180である。また、吸油剤とカシューナッツ殻粉砕物の場合の好ましい質量比は、15:100~60:100である。
本発明の飼料用組成物において、吸油剤と、カシューナッツ油と、硬化油との好ましい質量比は、80~120:60~100:80~120であり、吸油剤と、カシューナッツ殻粉砕物と、硬化油との好ましい質量比は、15~45:60~100:80~120である。
本明細書中において、飼料用組成物の剤形について、「粉状」、「粒状(ペレット状)」、「粉粒状」とは、手で強く握った状態でも固まらない、サラサラの状態をいう。この状態では、ほとんどのCNSLはシリカなどの吸油剤内部に吸着されており、担体表面にはほとんど露出していない。
飼料を摂取させる方法及び飼育する方法は、動物の種類に応じて、通常用いられる方法をとることができる。
(1)製剤試作
カシュー・トレーディング(株)より、カシューナッツの殻を入手し、圧搾でカシューナッツ殻油(CNSL)を搾油し、以下の試験に使用した。
CNSLの組成は以下の方法で測定した。すなわち、HPLC(Waters600、日本ウォーターズ株式会社)、検出機(Waters490E、日本ウォーターズ株式会社)、プリンタ(クロマトパックC-R6A、(株)島津製作所)、カラム(SUPELCOSIL LC18、SUPELCO社)を用いた。アセトニトリル:水:酢酸が80:20:1(用量比)の溶媒を用い、流速は2ml/分とした。280nmの吸光度で検出した。
カシューナッツ殻油には、アナカルド酸が61.8質量%、カルダノールが8.2質量%、カルドールが19.9質量%含まれていた。
CNSLは室温で液体又は固体であり、ヒトの皮膚に付着すると取れづらく、かぶれを引き起こす。このため、CNSLを担体内部に吸着させ担体の表面にCNSLが露出していない製剤を作成するため、CNSLと平均粒径100μmのシリカ(商品名Siprnat22、degussa社製品)を混合し粉状の飼料用組成物を作成した。
結果を表1に示す。
12週齢のウサギ(Jla:JW)雌40匹を、馴化飼育し、異常の認められない健康と思われる動物を試験に供した。
室温22±4℃、湿度55±15%、明暗各12時間(照明時間:午前8時~午後8時)に設定された飼育室で、金属製ブラケットケージを用いて個別に飼育し、飼料はCR-3(日本クレア株式会社製)及び飲料水を自由摂取させた。
4時間後にリント布を除去し、貼付部位に残存する被験物質を局方精製水で清拭し、除去後1, 24, 48, 72時間後に皮膚の状態を観察した。72時間以降に障害が残存する場合は24時間毎に7日まで観察を継続した。
紅斑および痂皮の形成
紅斑なし 0
非常に軽度の紅斑(かろうじて識別できる) 1
はっきりした紅斑 2
中程度ないし高度紅斑 3
高度紅斑(Beet redness)から僅かな痂皮の形成
(深部損傷)まで 4
浮腫の形成
浮腫なし 0
非常に軽度の浮腫 1
軽度浮腫(はっきりとした膨隆による明確な縁が識別できる) 2
中程度浮腫(約1 mmの膨隆) 3
高度浮腫(1 mmの膨隆と暴露範囲を越えた広がり) 4
最高点 4
(1)製剤試作
カシュー・トレーディング(株)より、カシューナッツの殻を入手し、以下の試験に供した。
カシューナッツ殻とシリカ(商品名Siprnat22、degussa社製品)を、粉砕機(オスターブレンダー、アズワン社製品)で均一に粉砕し、粉状の飼料用組成物を作成した。
結果を表3に示す。
実施例1と同様に皮膚刺激性を評価した。
結果を表4に示す。
CNSLのS. bovisに対する抗菌作用を調べるため、Staphylococcos aureus牛分離菌株、S. bovis DSM20065株、Bacillus subtilis NBRC3009株、Escherichia coli ATCC11303株、Pseudomonas aeruginosa NBRC12689株、およびSaccharomyces cerevisiae NBRC10217株をブレインハートインフュージョン培地(日水製薬(株)製品)で37℃で1日培養した。CNSLを添加したブレインハートインフュージョン培地に10μL植菌し、37℃で2日間培養し最小生育阻止濃度(MIC)を算出した。
結果を表5に示す。
(1)試料
ルーメンカニューレを装着しためん羊4頭に、体重の1.4質量%相当の餌(濃厚飼料:乾草=3:7(体積))を給与した。
実験例1-1の供試剤の投与開始前に一回目のルーメン内容物のサンプリングを行った。初めの2週間は餌に実験例1-1の供試剤を0.4(質量)%給与し、1週間毎2回ルーメン内容物のサンプリングを行った。次の2週間は餌に実験例1-5の供試剤を1.0(質量)%給与し、1週間毎2回ルーメン内容物のサンプリングを行った。次の2週間は無投与で餌のみ給与し、1週間毎2回ルーメン内容物のサンプリングを行った。
ルーメン液のpHを表6に示す。
ルーメン液の粘度(CP)、ルーメン液の起泡性(IVI(%))および泡沫安定性(sIVI(%))を表7に示す。
採取したルーメン液を試験管内に密閉し37℃で24時間培養したときに生成したガス量(ml/日/tube)を表8に示す。
採取したルーメン液中の総VFA濃度(mmol/dl)、酢酸モル比(%)、プロピオン酸モル比(%)および酪酸モル比(%)を表9に示す。
採取したルーメン液中のアンモニア濃度(mgN/dl)を表10に示す。
実際のルーメンの中で、二酸化炭素およびメタンが実験例1-1および1-5の供試剤添加で有意に減少し、この時メタン低下にともなう水素の集積が見られないことから嫌気発酵で生じる水素は代替水素消費系へ円滑に移行していると思われる。また、総VFA濃度は実験例1-1および1-5の供試剤を添加しても変化しなかった(発酵そのものの抑制はない)。しかし発酵パターンは顕著に変化し、酢酸生成が有意に減り、プロピオン酸生成が有意に増えた。すなわちルーメン機能が改善された。
この結果は、メタン生成の低下とよくリンクしており、水素の代替消費系としてプロピオン酸生成が円滑に発達したと考えられる。以上のことが、実際に羊を用いたルーメン内で実証された事から、カシューナッツ殻油は、家畜のエネルギーおよび蛋白質利用効率を高めると考えられる。
(1)製剤試作
パーム極度硬化油(商品名:PW-50、横関油脂工業(株)製品、融点50℃)を60℃のウォーターバスで溶かし、50℃に加温しておいたCNSLと均一に混合後、シリカ(商品名Siprnat22、degussa社製品)を加え、よく混合し、ディスクペレッターF-5型((株)テクノパウダルトン製品)を用い造粒した。
CNSL、200gにシリカ(商品名Siprnat22、degussa社製品)200gを加え、よく混合し、さらにPVA(商品名:ゴーセノールNH26、日本合成化学製品)200gを加えディスクペレッターF-5型((株)テクノパウダルトン製品)を用い造粒した。70℃で40分乾燥する事により充分硬いペレットを得る事ができ、比較例2-5の供試剤とした。
12週齢のウサギ(Jla:JW)雌45匹を、馴化飼育し、異常の認められない健康と思われる動物を試験に供した。
室温22±4℃、湿度55±15%、明暗各12時間(照明時間:午前8時~午後8時)に設定された飼育室で、金属製ブラケットケージを用いて個別に飼育し、飼料はCR-3(日本クレア株式会社製)及び飲料水を自由摂取させた。
4時間後にリント布を除去し、貼付部位に残存する被験物質を局方精製水で清拭し、除去後1, 24, 48, 72時間後に皮膚の状態を観察した。72時間以降に障害が残存する場合は24時間毎に7日まで観察を継続した。
紅斑および痂皮の形成
紅斑なし 0
非常に軽度の紅斑(かろうじて識別できる) 1
はっきりした紅斑 2
中程度ないし高度紅斑 3
高度紅斑(Beet redness)から僅かな痂皮の形成
(深部損傷)まで 4
浮腫の形成
浮腫なし 0
非常に軽度の浮腫 1
軽度浮腫(はっきりとした膨隆による明確な縁が識別できる) 2
中程度浮腫(約1 mmの膨隆) 3
高度浮腫(1 mmの膨隆と暴露範囲を越えた広がり) 4
最高点 4
(1)製剤試作
カシューナッツの殻とシリカ(商品名Siprnat22、degussa社製品)を、粉砕機(オスターブレンダー、アズワン社製品)で均一に粉砕した。粉砕物に、あらかじめ溶かしておいたパーム極度硬化油を加え、よく混合し、ディスクペレッターF-5型((株)テクノパウダルトン製品)を用い造粒した。
結果を表15に示す。
(2)皮膚刺激性
実施例1と同様に皮膚刺激性を評価した。結果を表16に示す。
(1)試料
ルーメンカニューレを装着しためん羊4頭に、体重の1.4質量%相当の餌(濃厚飼料:乾草=3:7(体積))を給与した。
比較例2-5の供試剤の投与開始前に一回目のルーメン内容物のサンプリングを行った。初めの2週間は餌に比較例2-5の供試剤を0.75質量%給与し、1週間毎2回ルーメン内容物のサンプリングを行った。次の2週間は餌に実験例2-2の供試剤を0.75質量%給与し、1週間毎2回ルーメン内容物のサンプリングを行った。次の2週間は無投与で餌のみ給与し、1週間毎2回ルーメン内容物のサンプリングを行った。
ルーメン液のpHを表17に示す。
ルーメン液の粘度(CP)、ルーメン液の起泡性(IVI(%))および泡沫安定性(sIVI(%))を表18に示す。
採取したルーメン液を試験管内に密閉し37℃で24時間培養したときに生成したガス量(ml/日/tube)を表19に示す。
採取したルーメン液中の総VFA濃度(mmol/dl)、酢酸モル比(%)、プロピオン酸モル比(%)および酪酸モル比(%)を表20に示す。
採取したルーメン液中のアンモニア濃度(mgN/dl)を表21に示す。
実際のルーメンの中で、二酸化炭素およびメタンが実験例2-2の供試剤添加で有意に減少し、この時メタン低下にともなう水素の集積が見られないことから嫌気発酵で生じる水素は代替水素消費系へ円滑に移行していると思われる。また、総VFA濃度は実験例2-2の供試剤を添加しても変化しなかった(発酵そのものの抑制はない)。しかし発酵パターンは顕著に変化し、酢酸生成が有意に減り、プロピオン酸生成が有意に増えた。すなわちルーメン機能が改善された。しかしながら、製造時に加熱処理した比較例2-5の供試剤にはルーメン機能改善効果は認められなかった。アナカルド酸は70℃以上に加熱するとカルダノールに変化するが、カルダノールにはルーメン機能改善効果が無いと考えられる。
この結果は、メタン生成の低下とよくリンクしており、水素の代替消費系としてプロピオン酸生成が円滑に発達したと考えられる。以上のことが、実際に羊を用いたルーメン内で実証された事から、カシューナッツ殻油は、家畜のエネルギーおよび蛋白質利用効率を高めると考えられる。
本発明の飼料用組成物は、粉剤または粒剤に加工する事により、CNSLが粘稠な液体でべたべたして餌に混合するのが難しいという欠点を解消し、ハンドリング性を向上させることができる。また、CNSL原液は皮膚に付着すると取れずかぶれるが、シリカに吸着させる事により皮膚に油が接触しなくなりかぶれを防ぐことができる。
Claims (12)
- カシューナッツ殻油及び/又はアナカルド酸類と吸油剤からなり、前記カシューナッツ殻油及び/又はアナカルド酸類を飼料用組成物全量基準で25質量%~65質量%含有することを特徴とする、粉粒状の飼料用組成物。
- カシューナッツの殻粉砕物と吸油剤からなり、前記カシューナッツ殻粉砕物を飼料用組成物全量基準で10質量%~90質量%含有することを特徴とする、粉粒状の飼料用組成物。
- 前記吸油剤が酸化マグネシウム、ステアリン酸塩、タルクおよびシリカの群から選ばれる1種以上であることを特徴とする、請求項1又は2記載の粉粒状の飼料用組成物。
- 前記吸油剤が100g当たり50~300gの油を吸着する吸油剤である、請求項3記載の粉粒状の飼料用組成物。
- 前記吸油剤が粒径2~200μmの粒子であることを特徴とする、請求項4に記載の粉粒状の飼料用組成物。
- さらに硬化油を含む、請求項1~5のいずれか1項に記載の粉粒状の飼料用組成物。
- 請求項1~6のいずれか1項に記載の飼料用組成物を含むことを特徴とする、飼料。
- 前記カシューナッツ殻油を飼料全量基準で0.02~4.0質量%含有することを特徴とする請求項7記載の飼料。
- 反芻動物用である、請求項7又は8記載の飼料。
- 請求項7~9のいずれか1項記載の飼料を摂取させることを特徴とする家畜の飼育方法。
- 粉粒状の飼料用組成物を製造するための、カシューナッツ殻油及び/又はアナカルド酸類と吸油剤の使用。
- カシューナッツ殻油及び/又はアナカルド酸類と吸油剤を投与することを特徴とする家畜の治療方法。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK09762478.7T DK2298082T3 (da) | 2008-06-09 | 2009-06-09 | Sammensætning til foder og foder omfattende denne |
CN200980122260.3A CN102056495B (zh) | 2008-06-09 | 2009-06-09 | 饲料用组合物以及含有该饲料用组合物的饲料 |
BRPI0914907A BRPI0914907B8 (pt) | 2008-06-09 | 2009-06-09 | composição particulada para ração e ração |
ES09762478T ES2749386T3 (es) | 2008-06-09 | 2009-06-09 | Composición para pienso, y pienso que comprende la misma |
EP09762478.7A EP2298082B1 (en) | 2008-06-09 | 2009-06-09 | Composition for feed, and feed comprising the same |
JP2010516858A JP5634261B2 (ja) | 2008-06-09 | 2009-06-09 | 飼料用組成物およびそれを含有する飼料 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008150966 | 2008-06-09 | ||
JP2008-150966 | 2008-06-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009151048A1 true WO2009151048A1 (ja) | 2009-12-17 |
Family
ID=41416755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2009/060519 WO2009151048A1 (ja) | 2008-06-09 | 2009-06-09 | 飼料用組成物およびそれを含有する飼料 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2298082B1 (ja) |
JP (1) | JP5634261B2 (ja) |
CN (1) | CN102056495B (ja) |
BR (1) | BRPI0914907B8 (ja) |
DK (1) | DK2298082T3 (ja) |
ES (1) | ES2749386T3 (ja) |
WO (1) | WO2009151048A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012060451A1 (ja) * | 2010-11-05 | 2012-05-10 | 出光興産株式会社 | 安定性が向上したカシューナッツ殻油 |
CN102933696A (zh) * | 2010-06-03 | 2013-02-13 | 出光兴产株式会社 | 稳定性提高的腰果壳油 |
WO2014142113A1 (ja) | 2013-03-13 | 2014-09-18 | 出光興産株式会社 | カシューナッツ殻油等を含有するシリカ製剤 |
JP2016039791A (ja) * | 2014-08-13 | 2016-03-24 | 兼松新東亜食品株式会社 | 牛用の固形混合飼料 |
WO2020162599A1 (ja) | 2019-02-08 | 2020-08-13 | 出光興産株式会社 | 機能性飼料 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011078928A1 (en) | 2009-12-22 | 2011-06-30 | Casella Waste Systems, Inc. | Sorbent containing engineered fuel feed stocks |
PL2807238T3 (pl) | 2012-01-26 | 2018-12-31 | Accordant Energy, Llc | Łagodzenie szkodliwych emisji spalania przy użyciu paliw surowcowych zawierających sorbent |
US20130224320A1 (en) * | 2012-02-23 | 2013-08-29 | Joan Torrent Campmany | Process to improve feed efficiency and carcass characteristics of animals |
CN106387353A (zh) * | 2016-08-31 | 2017-02-15 | 广州市义和化工有限公司 | 一种饲料用组合物及其制造方法 |
EP3843762B1 (en) * | 2018-08-31 | 2023-09-20 | Innophos, LLC | Anti-inflammatory botanical extract of anacardium occidentale |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03240721A (ja) | 1990-02-20 | 1991-10-28 | Mikimoto Seiyaku Kk | 口腔用組成物 |
JPH03240716A (ja) | 1989-10-30 | 1991-10-28 | Union Carbide Chem & Plast Co Inc | スキンケアに有効なポリマー混合物 |
JPH08231410A (ja) | 1995-02-23 | 1996-09-10 | Takasago Internatl Corp | コクシジウム症軽減剤及びそれを含有する飼料 |
WO2001028551A1 (fr) | 1999-10-19 | 2001-04-26 | Fujisawa Pharmaceutical Co., Ltd. | Agents favorisant l'engraissement d'animaux et procede favorisant l'engraissement |
JP2001151675A (ja) * | 1999-11-26 | 2001-06-05 | Nisshin Flour Milling Co Ltd | コクシジウム症の予防および/または治療用飼料 |
WO2006137289A1 (ja) * | 2005-06-21 | 2006-12-28 | Mitsubishi Chemical Corporation | 含油固形物およびその製造方法 |
JP2007209224A (ja) * | 2006-02-08 | 2007-08-23 | Ohta Oil Mill Co Ltd | 飼料用吸着油脂とその製造方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH687053A5 (fr) * | 1993-10-05 | 1996-09-13 | Crina | Additifs pour l'alimentation animale et procédé pour leur préparation. |
JP2003238400A (ja) * | 2002-02-12 | 2003-08-27 | Nippon Zenyaku Kogyo Kk | 抗コクシジウム組成物及びそれを含有する飼料 |
AU2003284625A1 (en) * | 2002-11-22 | 2004-06-18 | Kunimine Industries Co., Ltd. | Granular composition and process for producing the same |
-
2009
- 2009-06-09 WO PCT/JP2009/060519 patent/WO2009151048A1/ja active Application Filing
- 2009-06-09 ES ES09762478T patent/ES2749386T3/es active Active
- 2009-06-09 DK DK09762478.7T patent/DK2298082T3/da active
- 2009-06-09 CN CN200980122260.3A patent/CN102056495B/zh active Active
- 2009-06-09 BR BRPI0914907A patent/BRPI0914907B8/pt active Search and Examination
- 2009-06-09 JP JP2010516858A patent/JP5634261B2/ja active Active
- 2009-06-09 EP EP09762478.7A patent/EP2298082B1/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03240716A (ja) | 1989-10-30 | 1991-10-28 | Union Carbide Chem & Plast Co Inc | スキンケアに有効なポリマー混合物 |
JPH03240721A (ja) | 1990-02-20 | 1991-10-28 | Mikimoto Seiyaku Kk | 口腔用組成物 |
JPH08231410A (ja) | 1995-02-23 | 1996-09-10 | Takasago Internatl Corp | コクシジウム症軽減剤及びそれを含有する飼料 |
WO2001028551A1 (fr) | 1999-10-19 | 2001-04-26 | Fujisawa Pharmaceutical Co., Ltd. | Agents favorisant l'engraissement d'animaux et procede favorisant l'engraissement |
JP2001151675A (ja) * | 1999-11-26 | 2001-06-05 | Nisshin Flour Milling Co Ltd | コクシジウム症の予防および/または治療用飼料 |
WO2006137289A1 (ja) * | 2005-06-21 | 2006-12-28 | Mitsubishi Chemical Corporation | 含油固形物およびその製造方法 |
JP2007209224A (ja) * | 2006-02-08 | 2007-08-23 | Ohta Oil Mill Co Ltd | 飼料用吸着油脂とその製造方法 |
Non-Patent Citations (6)
Title |
---|
BENCHAAR ET AL., CAN. J. ANIM. SCI., vol. 86, 2006, pages 91 - 96 |
DILORENZO ET AL., J. ANIM. SCI., vol. 84, 2006, pages 2178 - 2185 |
HIMEJIMA M.; KUBO I., J. AGRIC. FOOD CHEM., vol. 39, 1991, pages 418 - 421 |
MUROI, H. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, 2004, pages 583 - 587 |
SHU ET AL., FEMS IMMUNOLOGY & MEDICAL MICROBIOLOGY, vol. 26, no. 2, 1999, pages 153 - 158 |
VAN NEVEL C. J. ET AL., APPLIED MICROBIOLOGY, vol. 21, 1971, pages 365 - 366 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102933696A (zh) * | 2010-06-03 | 2013-02-13 | 出光兴产株式会社 | 稳定性提高的腰果壳油 |
WO2012060451A1 (ja) * | 2010-11-05 | 2012-05-10 | 出光興産株式会社 | 安定性が向上したカシューナッツ殻油 |
CN103189488A (zh) * | 2010-11-05 | 2013-07-03 | 出光兴产株式会社 | 稳定性提升的腰果壳油 |
WO2014142113A1 (ja) | 2013-03-13 | 2014-09-18 | 出光興産株式会社 | カシューナッツ殻油等を含有するシリカ製剤 |
JP5706053B2 (ja) * | 2013-03-13 | 2015-04-22 | 出光興産株式会社 | カシューナッツ殻油等を含有するシリカ製剤 |
US11382342B2 (en) | 2013-03-13 | 2022-07-12 | Idemitsu Kosan Co., Ltd. | Silica formulation including cashew nut shell liquid or the like |
JP2016039791A (ja) * | 2014-08-13 | 2016-03-24 | 兼松新東亜食品株式会社 | 牛用の固形混合飼料 |
WO2020162599A1 (ja) | 2019-02-08 | 2020-08-13 | 出光興産株式会社 | 機能性飼料 |
CN113412057A (zh) * | 2019-02-08 | 2021-09-17 | 出光兴产株式会社 | 功能性饲料 |
Also Published As
Publication number | Publication date |
---|---|
CN102056495A (zh) | 2011-05-11 |
BRPI0914907B8 (pt) | 2017-05-09 |
ES2749386T3 (es) | 2020-03-20 |
BRPI0914907A8 (pt) | 2016-11-01 |
CN102056495B (zh) | 2014-09-03 |
BRPI0914907A2 (pt) | 2015-08-25 |
DK2298082T3 (da) | 2019-10-14 |
EP2298082A1 (en) | 2011-03-23 |
BRPI0914907B1 (pt) | 2016-12-27 |
EP2298082B1 (en) | 2019-07-31 |
EP2298082A4 (en) | 2011-06-22 |
JP5634261B2 (ja) | 2014-12-03 |
JPWO2009151048A1 (ja) | 2011-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5634261B2 (ja) | 飼料用組成物およびそれを含有する飼料 | |
JP5424401B2 (ja) | 反芻動物の鼓脹症防除剤 | |
AU2010276790B2 (en) | Coated formulation | |
JP5502754B2 (ja) | 家畜のクロストリディウム属細菌による疾病の予防及び/又は治療用飼料、並びに抗クロストリディウム剤 | |
EP3466437B1 (en) | Perinatal disease preventive or therapeutic agent for ruminant | |
WO2009139468A1 (ja) | コクシジウム症防除剤およびそれを含有する飼料 | |
JPWO2015056729A1 (ja) | 機能性飼料 | |
JP2008035760A (ja) | 反芻動物用飼料 | |
AU2015252032B2 (en) | Agent for improving milk yield and/or milk quality of ruminants, preventive or therapeutic agent for perinatal disease, and agent for improving reproductive efficiency |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200980122260.3 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09762478 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010516858 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 30/CHENP/2011 Country of ref document: IN Ref document number: 2009762478 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0914907 Country of ref document: BR Kind code of ref document: A2 Effective date: 20101208 |