WO2009140897A1 - Absorbant de purifiant sanguin utilisé pour l’élimination d’anticorps - Google Patents

Absorbant de purifiant sanguin utilisé pour l’élimination d’anticorps Download PDF

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Publication number
WO2009140897A1
WO2009140897A1 PCT/CN2009/071714 CN2009071714W WO2009140897A1 WO 2009140897 A1 WO2009140897 A1 WO 2009140897A1 CN 2009071714 W CN2009071714 W CN 2009071714W WO 2009140897 A1 WO2009140897 A1 WO 2009140897A1
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WO
WIPO (PCT)
Prior art keywords
water
ethanol
dissolved
rabbit
dispersed
Prior art date
Application number
PCT/CN2009/071714
Other languages
English (en)
Chinese (zh)
Inventor
贾凌云
任军
Original Assignee
大连理工大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 大连理工大学 filed Critical 大连理工大学
Publication of WO2009140897A1 publication Critical patent/WO2009140897A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption

Abstract

Un absorbant de purifiant sanguin constitué de vecteurs à l’état solide et de ligands fixés chimiquement sur lesdits vecteurs et ayant la structure moléculaire suivante : Parmi les trois atomes A, B, C, l’un étant un atome d’azote, les deux autres étant des atomes de carbone; n étant compris entre 0 et 2. L’absorbant de purifiant sanguin peut être utilisé d’une part pour éliminer les anticorps du plasma et, d’autre part comme diluant dans le processus de purification sanguine pour éliminer les auto-anticorps et le complexe immun du plasma.
PCT/CN2009/071714 2008-05-20 2009-05-08 Absorbant de purifiant sanguin utilisé pour l’élimination d’anticorps WO2009140897A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200810011530.0 2008-05-20
CNA2008100115300A CN101279242A (zh) 2008-05-20 2008-05-20 用于抗体清除的血液净化吸附剂

Publications (1)

Publication Number Publication Date
WO2009140897A1 true WO2009140897A1 (fr) 2009-11-26

Family

ID=40012022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2009/071714 WO2009140897A1 (fr) 2008-05-20 2009-05-08 Absorbant de purifiant sanguin utilisé pour l’élimination d’anticorps

Country Status (2)

Country Link
CN (1) CN101279242A (fr)
WO (1) WO2009140897A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2665358A1 (fr) * 2011-01-06 2013-11-27 Cytosorbents Corporation Sorbant polymère permettant d'éliminer les impuretés présentes dans le sang entier et les produits sanguins
EP2698636A1 (fr) * 2012-08-13 2014-02-19 Fundació Institut d'Investigació Biomèdica de Bellvitge Procédés et réactifs pour la prévention et/ou le traitement d'un rejet de greffe

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101279242A (zh) * 2008-05-20 2008-10-08 大连理工大学 用于抗体清除的血液净化吸附剂
DE102009034150A1 (de) * 2009-07-20 2011-01-27 Fresenius Medical Care Deutschland Gmbh Adsorbens zur Adsorption von Hepcidin
JP6138783B2 (ja) * 2011-08-12 2017-05-31 サイトソーベンツ・コーポレーション 全血および血液製剤から不純物を除去するためのポリマー収着剤
CN103028376B (zh) * 2011-09-29 2015-05-13 佛山市博新生物科技有限公司 一种用于清除血液毒素的血液净化吸附剂及其制备方法
CN103331147B (zh) * 2013-07-08 2014-10-15 大连理工大学 一种特异性清除甲状旁腺激素的血液净化吸附剂的制备方法
CN103933947B (zh) * 2014-04-10 2015-10-14 大连理工大学 用于清除类风湿因子的血液净化材料及其制备方法
CN105170110A (zh) * 2015-05-18 2015-12-23 西北大学 一种磁性复合纳米粒子及其制备方法
CN109092261B (zh) * 2018-08-20 2021-03-26 武汉瑞法医疗器械有限公司 一种用于清除血液中低密度脂蛋白的吸附清除剂及其制备方法
CN110711276B (zh) * 2019-09-06 2022-05-17 武汉瑞法医疗器械有限公司 一种稳定吸附剂吸附性能的保存液
CN110665478B (zh) * 2019-09-06 2022-08-23 武汉瑞法医疗器械有限公司 一种用于稳定吸附剂吸附性能的填充液及其应用
CN113926434A (zh) * 2021-11-03 2022-01-14 上海江夏血液技术有限公司 一种蛋白吸附膜材料及其制备方法和应用

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CN101284224A (zh) * 2008-05-14 2008-10-15 浙江大学 以巯基乙基吡啶和砜基为配基分离抗体的扩张床吸附介质及制备方法

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2665358A1 (fr) * 2011-01-06 2013-11-27 Cytosorbents Corporation Sorbant polymère permettant d'éliminer les impuretés présentes dans le sang entier et les produits sanguins
EP2665358A4 (fr) * 2011-01-06 2014-06-25 Cytosorbents Corp Sorbant polymère permettant d'éliminer les impuretés présentes dans le sang entier et les produits sanguins
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
CN109847403A (zh) * 2011-01-06 2019-06-07 西托索尔本茨公司 用于从全血和血液制品中移除杂质的聚合物吸附剂
EP2698636A1 (fr) * 2012-08-13 2014-02-19 Fundació Institut d'Investigació Biomèdica de Bellvitge Procédés et réactifs pour la prévention et/ou le traitement d'un rejet de greffe
WO2014026950A1 (fr) * 2012-08-13 2014-02-20 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Procédés et réactifs pour la prévention et/ou le traitement d'un rejet de greffe
JP2015528568A (ja) * 2012-08-13 2015-09-28 フンダシオ インスティトゥト ディンベスティガシオ ビオメディカ デベイビジャ（イ デ イ ベ エ エレ エレ）Ｆｕｎｄａｃｉｏ Ｉｎｓｔｉｔｕｔ Ｄ’Ｉｎｖｅｓｔｉｇａｃｉｏ Ｂｉｏｍｅｄｉｃａ Ｄｅ Ｂｅｌｌｖｉｔｇｅ （Ｉｄｉｂｅｌｌ） 移植拒絶の予防および／または治療のための方法および試薬
US9719987B2 (en) 2012-08-13 2017-08-01 Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) Immunoadsorbent compositions comprising hyaluronic acid oligosaccharides

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