WO2009093326A1 - Lentille de contact conditionnée et procédé de conditionnement de lentilles de contact - Google Patents

Lentille de contact conditionnée et procédé de conditionnement de lentilles de contact Download PDF

Info

Publication number
WO2009093326A1
WO2009093326A1 PCT/JP2008/051044 JP2008051044W WO2009093326A1 WO 2009093326 A1 WO2009093326 A1 WO 2009093326A1 JP 2008051044 W JP2008051044 W JP 2008051044W WO 2009093326 A1 WO2009093326 A1 WO 2009093326A1
Authority
WO
WIPO (PCT)
Prior art keywords
contact lens
container
liquid medium
anionic
group
Prior art date
Application number
PCT/JP2008/051044
Other languages
English (en)
Japanese (ja)
Inventor
Yoshitaka Yamada
Takashi Yamamoto
Hiroyuki Yamaguchi
Original Assignee
Menicon Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menicon Co., Ltd. filed Critical Menicon Co., Ltd.
Priority to PCT/JP2008/051044 priority Critical patent/WO2009093326A1/fr
Publication of WO2009093326A1 publication Critical patent/WO2009093326A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/086—Container, accessories or devices therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B25/00—Packaging other articles presenting special problems
    • B65B25/008—Packaging other articles presenting special problems packaging of contact lenses

Definitions

  • the present invention relates to a contact lens packaging product and a contact lens packaging method, and more particularly to a contact lens packaging product suitable for shipment of a contact lens from a manufacturer for provision to a consumer (user) and such a contact.
  • the present invention relates to a contact lens packaging method for advantageously obtaining a lens packaging product.
  • a contact lens is housed in a predetermined sealed container together with a liquid medium such as physiological saline for provision to a consumer who is a consumer (user).
  • a liquid medium such as physiological saline
  • Have been shipped as contact lens packaging products (CL packaging products) see Japanese translations of PCT publication No. 2004-523777 (patent document 1) and JP 2007-44536 (patent document 2). ) Etc.).
  • contact lenses in order to use contact lenses safely, care such as washing treatment for removing dirt such as protein and eye grease adhering to wearing and sterilization treatment to prevent the growth of bacteria and mold, It is necessary to do it on a daily basis.
  • hydrogel soft contact lenses and hydrous contact lenses such as silicone hydrogel contact lenses composed of a hydrophilic monomer and a silicone-based monomer, which are expected to grow in the future.
  • the lens since the lens contains water, it easily becomes a hotbed of bacteria and mold, and particularly appropriate care is required.
  • such a multi-purpose solution contains a suitable bactericide for realizing its purpose.
  • a suitable bactericide for realizing its purpose.
  • the bactericide polyhexamethylene biguanide (PHMB) or polyquaternium (polyquaternium) is used.
  • PHMB polyhexamethylene biguanide
  • polyquaternium polyquaternium
  • Cationic polymer fungicides such as benzalkonium chloride are used.
  • Such a cationic polymer disinfectant can kill various bacteria in a short time, thus effectively preventing the growth of bacteria, mold, etc. on the contact lens and in the preservation solution (MPS). Since the effect is obtained with a small amount (about 1 to 10 ppm), contact lenses treated with MPS containing such a bactericide are directly applied to the eyes without rinsing with other liquid agents. It has the feature that it can be worn.
  • contact lenses soaked in a liquid medium such as physiological saline are taken out from various commercially available contact lens packaging products, and are directly used as various commercially available multi-layers containing a cationic polymer disinfectant.
  • a liquid medium such as physiological saline
  • the cationic polymer disinfectant in the multi-purpose solution is impregnated or adsorbed on the inside or the surface of the contact lens.
  • SPK severe punctate superficial keratitis
  • Non-Patent Document 1 Pubidad.com
  • Stininggrid.jp/index.html Non-Patent Document 2
  • BritishBContact Lens Association “2007 conference”, published in 2007, p. 17, 104, 105, etc.
  • An object of the present invention is to provide a contact lens packaged product, and to provide a method for advantageously obtaining such a packaged product.
  • the present invention accommodates a liquid medium containing at least one anionic compound together with at least one contact lens in a predetermined sealable container.
  • a gist of a contact lens packaging product comprising: immersing the at least one contact lens in a liquid medium and sealing the container; and the container is sterilized. It is.
  • the anionic compound preferably has one or more anionic functional groups selected from the group consisting of a carboxyl group, a sulfo group and a phosphate group.
  • anionic compound those selected from the group consisting of anionic polysaccharides, glycyrrhizic acid and salts thereof, and anionic surfactants are advantageously used.
  • the anionic polysaccharide is preferably selected from the group consisting of chondroitin sulfate and salts thereof, hyaluronic acid and salts thereof, and alginic acid and salts thereof
  • the anionic surfactants include polyoxyethylene alkyl ether carboxylic acid and polyoxyethylene alkyl ether sulfuric acid and salts thereof (however, in any compound, oxyethylene units: 3 to 20, alkyl group Those selected from the group consisting of 6 to 20 carbon atoms are preferably used.
  • the at least one contact lens is shipped and provided to a user of the contact lens. It is also the gist.
  • the gist of the contact lens packaging method is characterized by including a step of sealing the container in the state of being performed.
  • the method further includes a step of heat sterilizing the sealed container.
  • At least one contact lens is immersed in a liquid medium containing at least one anionic compound and sealed in a predetermined container.
  • the contact lens is impregnated or adsorbed on the inside or surface of the contact lens with the anionic compound in the liquid medium sealed in the container.
  • MPS multi-purpose solution
  • cationic polymer disinfectant When contacted with the CL care solution, it will impregnate or adsorb inside or on the surface of the lens. Because are anionic compound, it become so as to effectively eliminate the toxicity of the cationic polymer fungicide in CL care solutions.
  • the contact lens is shipped before the contact lens is brought into contact with the cationic polymer disinfectant and after the contact lens packaging product is manufactured.
  • the anionic compound contained therein is sufficiently impregnated or adsorbed on the inside or surface of the contact lens. Therefore, the effect of eliminating the toxicity of the cationic polymer fungicide by the anionic compound described above can be advantageously exhibited.
  • an anionic compound suitable for the contact lens type is selected in advance as the anionic compound contained in the liquid medium in which the contact lens is immersed.
  • the contact lens wearer himself / herself does not need to consider any compatibility issues with the lens, and can easily and reliably use MPS, a preservative, a cleaning solution, a sterilizing solution, and a rinsing solution.
  • MPS MPS
  • a preservative a cleaning solution
  • sterilizing solution a sterilizing solution
  • a rinsing solution As a result, the toxicity of the cationic polymer disinfectant contained in the contact lens treatment solution (care solution) such as the above is effectively eliminated. Occurrence of eye disorders such as keratitis (SPK) can be effectively prevented.
  • FIG. 1 schematically shows an example of a contact lens packaged product (hereinafter also referred to as a CL packaged product) according to the present invention in the form of a longitudinal section.
  • the CL packaged product 2 here is a sealable packaging container 8 composed of a container body 4 and a lid sheet 6, and a container 1 accommodated in such a packaging container 8. It is comprised from the contact lens 10 of 1 sheet
  • the container body 4 has a housing recess 4a that opens upward, and an opening peripheral edge of the housing recess 4a extends outward. Part 4b.
  • the material for forming the container body 4 is not particularly limited, but is generally formed of a plastic material such as polypropylene that is chemically stable and resistant to dissolution with respect to the liquid medium 12 described later. ing.
  • the lid sheet 6 has a laminated structure composed of a base sheet 6a and resin film layers 6b and 6c bonded to the upper surface side and the lower surface side thereof with a known adhesive, respectively.
  • the material for forming the base sheet 6a is not particularly limited, but generally, metal foil, plastic film, synthetic paper and the like are advantageously used, and aluminum foil is particularly preferably used.
  • the material for forming the resin film layers 6b and 6c is not particularly limited, but generally has a sealing property, and the aseptic condition in the container can be advantageously maintained.
  • a synthetic resin such as polyethylene is preferably employed.
  • a lid sheet 6 is overlaid on the upper surface of the flange portion 4b of the container body 4 so as to fluid-tightly cover the opening of the accommodation recess 4a formed in the container body 4 described above, and is publicly known.
  • the packaging container 8 is formed by being attached using an adhesive or the like.
  • the type of contact lens 10 accommodated in the packaging container 8 is not particularly limited.
  • various kinds of soft contact lenses such as non-water-containing, low water-containing, and high water-containing can be used.
  • Any contact lens can be a target, but in the present invention, among these contact lenses, in particular, a hydrous soft contact lens or a contact lens made of silicone hydrogel is advantageously employed. It becomes.
  • liquid media such as the physiological saline conventionally used as a liquid medium which is accommodated in the packaging container 8 with such a contact lens 10, and the contact lens 10 is immersed.
  • the liquid medium 12 in which at least one kind of predetermined anionic compound is contained in the aqueous medium is used.
  • anionic compound to be contained in the liquid medium 12 in the present invention, any known anionic compound that is ophthalmically acceptable can be used as appropriate depending on the type of contact lens and the like.
  • one or more anionic properties selected from the group consisting of a carboxyl group, a sulfo group (sulfonic acid group), and a phosphoric acid group can be used.
  • Those having a functional group are advantageously employed, and specifically, anionic compounds such as anionic polysaccharides, glycyrrhizic acid and salts thereof, and anionic surfactants are advantageously used.
  • the anionic polysaccharide is preferably selected from the group consisting of chondroitin sulfate and salts thereof, hyaluronic acid and salts thereof, and alginic acid and salts thereof, such as chondroitin sulfate, sodium chondroitin sulfate, and hyaluron. Acids, sodium hyaluronate, alginic acid, sodium alginate and the like can be advantageously employed.
  • glycyrrhizic acid and its salt specifically, glycyrrhizic acid, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate and the like are advantageously used.
  • anionic surfactant a polyoxyethylene alkyl ether carboxylic acid having 3 to 20 oxyethylene units and an alkyl group having 6 to 20 carbon atoms, such as POE (6) tridecyl ether, is used.
  • dextran sulfate and its sodium salt L-2-pyrrolidone-5-carboxylic acid and its salt, and the like which are ophthalmically acceptable are known. Any of these anionic compounds can be used. In the present invention, the anionic compounds as described above may be used alone or in combination of two or more.
  • Such an anionic compound is appropriately selected in accordance with the purpose in consideration of various conditions.
  • the type of the contact lens 10 and the details will be described later.
  • a more suitable anionic compound can be advantageously employed, whereby the object of the present invention can be achieved even more advantageously. It will be.
  • the blending ratio of the anionic compound in the liquid medium 12 is not particularly limited, and is appropriately set according to the type of contact lens, anionic compound, or the like. However, generally, a blending ratio of 0.005 to 1 w / w%, preferably 0.02 to 0.5 w / w%, is advantageously employed. If the proportion of the anionic compound is too small, the amount of the anionic compound impregnated into the contact lens 10 or the amount of adsorption will be insufficient, and the above-described effects of the present invention may not be exhibited sufficiently. On the other hand, when the proportion of the anionic compound is too large, a salt composed of the anionic compound and the cationic polymer fungicide in the contact lens care solution such as MPS forms a precipitate. This is not desirable because
  • the liquid medium in which the contact lens 10 is immersed is a liquid in which an anionic compound is contained instead of a liquid medium such as conventional physiological saline. Since the medium 12 is used, the anionic compound contained in the liquid medium 12 is impregnated or adsorbed inside or on the surface of the contact lens 10 in the packaging container 8. Then, such a contact lens 10 is taken out from the CL packaging product 2 and cleaned, rinsed, stored, disinfected, etc. in a CL care solution such as MPS (multipurpose solution) containing a cationic polymer disinfectant. The anionic compound impregnated / adsorbed inside or on the surface of the contact lens 10 ionically binds to the cationic polymer disinfectant in the CL care solution, thereby reducing its toxicity. It will disappear effectively.
  • a CL care solution such as MPS (multipurpose solution) containing a cationic polymer disinfectant.
  • the liquid medium 12 used in the CL package product 2 according to the present invention includes a chelating agent and a tonicity adjusting agent as in the case of the conventional liquid medium for CL package products.
  • Nonionic surfactants, polysaccharide compounds and the like may be blended in the same blending ratio as before.
  • the above chelating agent is added to contact lenses, particularly soft contact lenses, in order to prevent deposition or adsorption of calcium contained in an aqueous medium in the liquid medium 12 or the like.
  • ethylenediaminetetraacetic acid (EDTA), ethylenediaminetetraacetic acid.2 sodium (EDTA.2Na), ethylenediaminetetraacetic acid.3 sodium (EDTA.3Na), etc. are generally about 0.01 to 0.5 w / w%. It is advantageously used at a concentration of.
  • the tonicity adjusting agent is blended in order to reduce irritation to the eye during wearing by adjusting the osmotic pressure of the liquid medium 12 to be close to the osmotic pressure of tear fluid.
  • inorganic salts such as sodium chloride and potassium chloride
  • nonionic tonicity adjusters such as sugars, sugar alcohols, polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol, and ethers and esters thereof are appropriately used.
  • Concentrations such as 0 to 0.2 w / w%, preferably about 0 to 0.1 w / w% for inorganic salts, and 0 to 0.1% for nonionic tonicity adjusters.
  • the osmotic pressure of the liquid medium 12 is in the range of about 0.75 to 1.6, preferably osmotic pressure ratio with respect to physiological saline (assuming the osmotic pressure of physiological saline is 1), preferably It is desirable that the adjustment is made in the range of about 0.8 to 1.5.
  • nonionic surfactant is added to remove dirt such as eye grease or to stably dissolve (solubilize) water-insoluble components in an aqueous medium.
  • the polysaccharide compound is blended in order to adjust the viscosity of the liquid medium 12.
  • cellulose, starch, dextrin, dextran, pullulan, or derivatives thereof are generally 0.002 It is advantageously used at a concentration of about ⁇ 3.0 w / w%.
  • water itself such as tap water, purified water, and distilled water
  • a solution mainly composed of water is highly safe to living bodies and can be sufficiently ophthalmically acceptable. As long as both are available, they can be used.
  • the target contact lens packaging product 2 is configured.
  • the inside of the packaging container 8 is sterilized by performing a treatment such as a heat sterilization treatment as necessary. Such sterilization is important in providing the contact lens 10 to the contact lens wearer in a sterile condition.
  • the packaging container 8 is sealed and the inside of the packaging container 8 is sterilized. It is possible to effectively prevent microorganisms such as bacteria and molds from growing in the packaging container 8 before the opening of the contact lens 10. Hygiene can be advantageously achieved.
  • the contact lens packaging product 2 according to the present invention as described above can be advantageously obtained by packaging the contact lens 10 as follows.
  • the container main body 4 and the lid sheet 6 of the packaging container 8 having the above-described configuration are respectively known in the same manner as a conventionally known method for manufacturing a contact lens packaging container, and a known resin molding operation or sheet laminating operation. It is formed by performing.
  • an anionic compound such as those described above, a chelating agent, a tonicity adjusting agent, and the like are added at a predetermined ratio to an aqueous medium such as purified water, and the liquid medium 12 is added.
  • an aqueous medium such as purified water
  • the liquid medium 12 prepared above is housed together with the single contact lens 10 in the housing recess 4 a of the container body 4 prepared previously, and the contact lens 10 is immersed in the liquid medium 12.
  • the flange portion 4b of the container body 4 and the lid sheet 6 are bonded with an adhesive, and the packaging container 8 is sealed.
  • a heat treatment thermal sterilization treatment
  • an autoclave In the heat treatment by the autoclave, conditions that do not adversely affect the contact lens 10 accommodated in the packaging container 8 are appropriately set.
  • the pressure is 2 atm
  • the temperature is 120 to 120.
  • the conditions of 125 ° C. and processing time: about 10 to 30 minutes are adopted.
  • the contact lens packaged product 2 according to the present invention is obtained.
  • the CL packaged product 2 obtained in this way is shipped after its manufacture in the same manner as a general CL packaged product. Through the distribution process, it will be delivered to the contact lens wearer.
  • the contact lens wearer (user) is provided before the cationic polymer disinfectant and the contact lens 10 are brought into contact with each other.
  • the anionic compound is sufficiently impregnated in the inside or the surface of the contact lens 10 for a long time after the contact lens packaged product 2 is manufactured and before it is opened by the user.
  • an anionic compound selected in advance according to the type of the contact lens 10 other additives in the liquid medium 12, etc. Because it is impregnated and adsorbed, contact lens wearers do not need to consider any compatibility issues with lenses, and they are easily and reliably included in CL care solutions such as MPS. This eliminates the toxicity of the cationic polymer fungicide, which effectively and effectively prevents the occurrence of eye disorders such as punctate superficial keratitis (SPK) caused by the cationic polymer fungicide. You will get.
  • SPK punctate superficial keratitis
  • the packaging container 8 only one contact lens 10 is accommodated in the packaging container 8, but in the present invention, it is sufficient that at least one contact lens 10 is accommodated.
  • the number of the contact lenses 10 that can be accommodated is not particularly limited.
  • the packaging container 8 is not limited to the structure illustrated in FIG. 1, and any of various conventionally known contact lens packaging containers can be appropriately employed depending on the purpose.
  • a contact lens packaging container disclosed in International Publication No. 2006/061886 pamphlet or International Publication No. 2004/019114 pamphlet can be appropriately employed.
  • the packaging container 8 is sealed and then subjected to a heat sterilization process so that the inside of the packaging container 8 is sterilized.
  • the inside of the packaging container 8 is sterilized. If it is in a state, such sterilization treatment is not always necessary, and such sterilization treatment is not limited to the above-described thermal sterilization, but also known sterilization such as sterilization treatment using ultraviolet rays or sterilization treatment using a bactericide. Any processing can be adopted as appropriate. If the sterilized state is maintained until the packaging container 8 is sealed, the sterilization by heating with an autoclave or ultraviolet irradiation may be performed before the packaging container 8 is sealed. Is possible.
  • a contact lens (10) a commercially available silicone hydrogel contact lens (manufactured by Menicon, PremiO) is prepared, while dipotassium glycyrrhizinate as an anionic compound, EDTA as a chelating agent, and tonicity.
  • a liquid medium (12) containing an anionic compound was prepared by containing and dissolving sodium chloride as a regulator in purified water at the blending ratio shown in Table 1 below.
  • the contact lens (10) was immersed in the liquid medium (12) prepared above, and autoclaved at 121 ° C., 2 atm, and 20 min. After the immersion, the lens (10) taken out of the liquid medium (12) was immersed in a commercially available multipurpose solution containing 1.1 ppm of PHMB for 24 hours.
  • the lens (10) was taken out from the multi-purpose solution, worn on the subject's eyes, and after 2 hours, the lens (10) was removed from the eyes. Then, the corneal staining test was performed by staining the ocular tissue after the removal with fluorescein staining. After the test, the anterior segment of the subject was observed visually.
  • Examples 2 to 4 As an anionic compound, it replaced with the dipotassium glycyrrhizinate of Example 1, respectively, except having used the compound shown by following Table 1 in the ratio shown in following Table 1, respectively, it was liquid like Example 1.
  • a medium (12) was prepared, and in the same manner, a staining test and an anterior ocular segment were observed. The results are also shown in Table 1 below.
  • Example 1 A liquid medium (12) was prepared in the same manner as in Example 1 except that an anionic compound was not contained, and a staining test and anterior eye observation were performed in the same manner. The results are also shown in Table 1 below.

Abstract

L'invention concerne une lentille de contact conditionnée qui permet de résoudre le problème des pathologies ophtalmiques engendrées par un bactéricide polymère cationique, et un procédé de production avantageux de cette lentille de contact conditionnée. Le procédé d'obtention de cette lentille de contact conditionnée (2) consiste à mettre une lentille de contact (10) et un milieu liquide (12) renfermant au moins un composé anionique dans un contenant (8) pouvant être fermé hermétiquement, immerger la lentille de contact (10) dans le milieu liquide (12), fermer hermétiquement le contenant (8) et stériliser l'intérieur du contenant (8).
PCT/JP2008/051044 2008-01-25 2008-01-25 Lentille de contact conditionnée et procédé de conditionnement de lentilles de contact WO2009093326A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2008/051044 WO2009093326A1 (fr) 2008-01-25 2008-01-25 Lentille de contact conditionnée et procédé de conditionnement de lentilles de contact

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2008/051044 WO2009093326A1 (fr) 2008-01-25 2008-01-25 Lentille de contact conditionnée et procédé de conditionnement de lentilles de contact

Publications (1)

Publication Number Publication Date
WO2009093326A1 true WO2009093326A1 (fr) 2009-07-30

Family

ID=40900844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051044 WO2009093326A1 (fr) 2008-01-25 2008-01-25 Lentille de contact conditionnée et procédé de conditionnement de lentilles de contact

Country Status (1)

Country Link
WO (1) WO2009093326A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10052916B2 (en) 2013-05-21 2018-08-21 Sumitomo Rubber Industries, Ltd. Pneumatic tire
JP2019219621A (ja) * 2018-06-22 2019-12-26 日油株式会社 コンタクトレンズ用溶液

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11271695A (ja) * 1998-03-25 1999-10-08 Menicon Co Ltd コンタクトレンズ用液剤
JP2001508555A (ja) * 1997-01-10 2001-06-26 アラーガン・セイルズ・インコーポレイテッド コンタクトレンズを保存するための組成物および方法
JP2004515813A (ja) * 2000-12-15 2004-05-27 ボシュ・アンド・ロム・インコーポレイテッド 生体材料への保存剤取り込みの防止

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001508555A (ja) * 1997-01-10 2001-06-26 アラーガン・セイルズ・インコーポレイテッド コンタクトレンズを保存するための組成物および方法
JPH11271695A (ja) * 1998-03-25 1999-10-08 Menicon Co Ltd コンタクトレンズ用液剤
JP2004515813A (ja) * 2000-12-15 2004-05-27 ボシュ・アンド・ロム・インコーポレイテッド 生体材料への保存剤取り込みの防止

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10052916B2 (en) 2013-05-21 2018-08-21 Sumitomo Rubber Industries, Ltd. Pneumatic tire
JP2019219621A (ja) * 2018-06-22 2019-12-26 日油株式会社 コンタクトレンズ用溶液
JP7099077B2 (ja) 2018-06-22 2022-07-12 日油株式会社 コンタクトレンズ用溶液

Similar Documents

Publication Publication Date Title
JP5033657B2 (ja) コンタクトレンズ用液剤及びコンタクトレンズ並びにコンタクトレンズに対する殺菌剤の付着防止方法
TW490483B (en) Method of disinfecting or cleaning and disinfecting a soft contact lens with a multi-purpose solution or effective multi-purpose solution and aqueous solution having a ph from 5 to 8 for treating contact lenses
JP3883739B2 (ja) コンタクトレンズ用殺菌液
JPH11249087A (ja) コンタクトレンズ用液剤
JP2004538096A (ja) ヒドロゲルによるビグアニド抗菌剤の取り込みを阻害するための組成物および方法
JP3894945B2 (ja) コンタクトレンズ用液剤
JP2012189993A (ja) コンタクトレンズ用液体組成物
JP2007513157A (ja) 殺生物効力を強化するためのカチオン性ポリサッカライドの使用
WO2009093326A1 (fr) Lentille de contact conditionnée et procédé de conditionnement de lentilles de contact
US4880601A (en) Hydrogen peroxide disinfecting system for contact lenses
JPH07508523A (ja) 眼科用組成物並びにそれを保存および使用する方法
JP4987170B1 (ja) コンタクトレンズの親水性向上システム及びそれのコンタクトレンズ・パッケージングへの適用
EP0079185B1 (fr) Solution de nettoyage
JP4484468B2 (ja) コンタクトレンズの消毒方法及びそのための消毒液
US4504405A (en) Method of cleaning soft contact lenses
US8227017B2 (en) System and method for enhancing the efficacy of antimicrobial contact lenses and other surfaces
JP5135526B2 (ja) コンタクトレンズ用液剤
EP0819968A1 (fr) Composition desinfectante/lavante pour lentilles de contact et procede de desinfection et de lavage de lentilles de contact a l'aide de cette composition
JPH06118354A (ja) コンタクトレンズ用洗浄保存液及びそれを用いたコンタクトレンズの洗浄、消毒方法
CN109042725B (zh) 一种用于清洁硬性接触镜的护理液及其制备方法
HU209538B (en) Set and cleaning composition for treating contactlenses
JP4519949B2 (ja) コンタクトレンズ用液剤組成物
IE920838A1 (en) Contact lens disinfecting compositions
JPWO2008041439A1 (ja) コンタクトレンズ用液剤
JPS59129299A (ja) コンタクトレンズ洗浄用水性組成物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08703871

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08703871

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP