WO2009069704A1 - 血中尿酸値低減作用を有する乳酸菌 - Google Patents

血中尿酸値低減作用を有する乳酸菌 Download PDF

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Publication number
WO2009069704A1
WO2009069704A1 PCT/JP2008/071559 JP2008071559W WO2009069704A1 WO 2009069704 A1 WO2009069704 A1 WO 2009069704A1 JP 2008071559 W JP2008071559 W JP 2008071559W WO 2009069704 A1 WO2009069704 A1 WO 2009069704A1
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WIPO (PCT)
Prior art keywords
lactic acid
uric acid
acid level
bodies
purine bodies
Prior art date
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PCT/JP2008/071559
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English (en)
French (fr)
Inventor
Hiroshi Tsuboi
Noriko Kaneko
Akina Satou
Akinori Kume
Katsunori Kimura
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Meiji Dairies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Dairies Corporation filed Critical Meiji Dairies Corporation
Priority to US12/745,006 priority Critical patent/US8389266B2/en
Priority to CN2008801259514A priority patent/CN102016004B/zh
Priority to CA2707187A priority patent/CA2707187C/en
Priority to JP2009543849A priority patent/JP5149305B2/ja
Priority to EP08854151.1A priority patent/EP2221360B1/en
Publication of WO2009069704A1 publication Critical patent/WO2009069704A1/ja
Priority to HK11109659.0A priority patent/HK1155481A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/145—Gasseri
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

　飲食品や医薬品用途に適し、血中尿酸値の上昇を抑制可能な乳酸菌を提供する。 　プリン体存在下で各種乳酸菌を培養し、該プリン体の消費量および該プリン体分解物の生産量を測定し、プリン体分解能の顕著な複数の乳酸菌を選抜した。上記選抜によってプリン体分解能が高いと判断された乳酸菌を、プリン体含有飼料で飼育したラットに経口投与し、当該ラットの一般状態および血清尿酸値を測定し、乳酸菌投与による血清尿酸値への影響を検討した。その結果、血清尿酸値の上昇を有意に抑える乳酸菌：Lactobacillus gasseri OLL2922を見出した。
PCT/JP2008/071559 2007-11-30 2008-11-27 血中尿酸値低減作用を有する乳酸菌 WO2009069704A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/745,006 US8389266B2 (en) 2007-11-30 2008-11-27 Lactic acid bacterium having effect of lowering blood uric acid level
CN2008801259514A CN102016004B (zh) 2007-11-30 2008-11-27 具有降低血中尿酸值作用的乳酸菌
CA2707187A CA2707187C (en) 2007-11-30 2008-11-27 Lactic acid bacterium having effect of lowering blood uric acid level
JP2009543849A JP5149305B2 (ja) 2007-11-30 2008-11-27 血中尿酸値低減作用を有する乳酸菌
EP08854151.1A EP2221360B1 (en) 2007-11-30 2008-11-27 Lactic acid bacterium having effect of lowering blood uric acid level
HK11109659.0A HK1155481A1 (en) 2007-11-30 2011-09-14 Lactic acid bacterium having effect of lowering blood uric acid level

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007310892 2007-11-30
JP2007-310892 2007-11-30

Publications (1)

Publication Number Publication Date
WO2009069704A1 true WO2009069704A1 (ja) 2009-06-04

Family

ID=40678596

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071559 WO2009069704A1 (ja) 2007-11-30 2008-11-27 血中尿酸値低減作用を有する乳酸菌

Country Status (8)

Country Link
US (1) US8389266B2 (ja)
EP (1) EP2221360B1 (ja)
JP (1) JP5149305B2 (ja)
KR (1) KR101584380B1 (ja)
CN (1) CN102016004B (ja)
CA (1) CA2707187C (ja)
HK (1) HK1155481A1 (ja)
WO (1) WO2009069704A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011083276A (ja) * 2009-10-16 2011-04-28 Food Industry Research & Development Inst 可食材のプリン含量を低減する方法
WO2015182155A1 (ja) * 2014-05-29 2015-12-03 日東薬品工業株式会社 新規乳酸菌及び該乳酸菌を含む組成物
WO2016080371A1 (ja) * 2014-11-18 2016-05-26 株式会社明治 プリン体の取り込み能を有する乳酸菌及びその用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2476747B1 (en) * 2007-11-29 2014-09-03 Meiji Co., Ltd Lactic acid bacteria having action of lowering blood uric acid level
WO2009069704A1 (ja) 2007-11-30 2009-06-04 Meiji Dairies Corporation 血中尿酸値低減作用を有する乳酸菌
US9441210B2 (en) 2013-06-26 2016-09-13 Food Industry Research And Development Institute Method of reducing levels of uric acid
US9649347B2 (en) * 2013-11-15 2017-05-16 Jiangnan University Protective effects and application of a Lactobacillus rhamnosus on the alleviation of chronic alcoholic liver injury
US9867857B2 (en) 2014-08-21 2018-01-16 Food Industry Research And Development Institute Acetobacter and gluconacetobacter strains and their metabolites for use in inhibiting xanthine oxidase
US9636368B2 (en) 2014-08-22 2017-05-02 Food Industry Research And Development Institute Strain of Lactobacillus rhamnosus and its metabolites for use in inhibiting xanthine oxidase and treating gout
CN105385640B (zh) * 2015-12-18 2018-07-27 广州市康优元生物科技有限公司 格氏乳球菌及其应用
CN106190908B (zh) * 2016-07-21 2018-11-23 上海清美绿色食品（集团）有限公司 一种植物乳杆菌x7021的应用
CN106754479B (zh) * 2016-11-24 2019-11-08 浙江大学宁波理工学院 一种弯曲乳杆菌及其应用
JP7104169B2 (ja) 2017-12-15 2022-07-20 グリーン・クロス・ウェルビーイング・コーポレーション 腎臓疾患進行抑制及び予防用プロバイオティクス及びこれを含む腎臓疾患進行抑制及び予防用組成物
WO2020006663A1 (zh) * 2018-07-02 2020-01-09 葡萄王生技股份有限公司 用于改善代谢症候群的新颖副干酪乳杆菌 gks6、其培养基、培养方法、用途、医药组合物及可食用组合物
CN110079476B (zh) * 2019-04-24 2020-12-08 杭州娃哈哈科技有限公司 一株可降低血尿酸的发酵乳杆菌
WO2021079869A1 (ja) * 2019-10-21 2021-04-29 ビオフェルミン製薬株式会社 尿毒素軽減剤
TWI788633B (zh) * 2019-12-11 2023-01-01 臺灣菸酒股份有限公司 新穎乳酸菌用於製備嘌呤化合物降解劑之用途
CN112725216B (zh) * 2020-11-10 2022-07-08 扬州大学 一株高效降解嘌呤的鼠李糖乳杆菌YZULr026及其应用
CN113143972B (zh) * 2021-05-19 2023-11-24 吉林省命之元生物科技有限公司 嗜热链球菌timr0705-6在制备抗高尿酸血症和抗痛风药物中的应用
CN115725437B (zh) * 2022-07-20 2024-04-30 江南大学 一株高效利用嘌呤的发酵粘液乳杆菌及其在黄酒酿造中的应用

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011083276A (ja) * 2009-10-16 2011-04-28 Food Industry Research & Development Inst 可食材のプリン含量を低減する方法
US8460724B2 (en) 2009-10-16 2013-06-11 Food Industry Research And Development Institute Method of reducing the purine content of an edible material
WO2015182155A1 (ja) * 2014-05-29 2015-12-03 日東薬品工業株式会社 新規乳酸菌及び該乳酸菌を含む組成物
JPWO2015182155A1 (ja) * 2014-05-29 2017-04-20 日東薬品工業株式会社 新規乳酸菌及び該乳酸菌を含む組成物
WO2016080371A1 (ja) * 2014-11-18 2016-05-26 株式会社明治 プリン体の取り込み能を有する乳酸菌及びその用途

Also Published As

Publication number Publication date
EP2221360A1 (en) 2010-08-25
KR20100109911A (ko) 2010-10-11
EP2221360B1 (en) 2014-03-05
CA2707187A1 (en) 2009-06-04
HK1155481A1 (en) 2012-05-18
CN102016004A (zh) 2011-04-13
JPWO2009069704A1 (ja) 2011-04-14
EP2221360A4 (en) 2011-11-02
JP5149305B2 (ja) 2013-02-20
CA2707187C (en) 2016-05-31
US20100316618A1 (en) 2010-12-16
CN102016004B (zh) 2012-11-28
KR101584380B1 (ko) 2016-01-21
US8389266B2 (en) 2013-03-05

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