WO2009066731A1 - 測定試薬、それを用いた免疫比濁法および検体分析用具 - Google Patents

測定試薬、それを用いた免疫比濁法および検体分析用具 Download PDF

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Publication number
WO2009066731A1
WO2009066731A1 PCT/JP2008/071121 JP2008071121W WO2009066731A1 WO 2009066731 A1 WO2009066731 A1 WO 2009066731A1 JP 2008071121 W JP2008071121 W JP 2008071121W WO 2009066731 A1 WO2009066731 A1 WO 2009066731A1
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Prior art keywords
insoluble carrier
carrier particle
measurement reagent
contained
analyte
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PCT/JP2008/071121
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English (en)
French (fr)
Inventor
Hidenori Takagi
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Arkray, Inc.
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Application filed by Arkray, Inc. filed Critical Arkray, Inc.
Priority to JP2009506462A priority Critical patent/JPWO2009066731A1/ja
Priority to EP08851516A priority patent/EP2146207A4/en
Priority to CN200880017706A priority patent/CN101680891A/zh
Priority to US12/599,153 priority patent/US20100240150A1/en
Publication of WO2009066731A1 publication Critical patent/WO2009066731A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　不溶性担体粒子量およびモノクローナル抗体量が抑制され、低濃度範囲の測定対象物に対する測定感度が向上し、広い濃度範囲で測定対象物を測定可能であり、かつ、試験片等の検体分析用具にも適用可能な免疫比濁法に用いる測定試薬を提供する。前記測定試薬は、平均粒子径が異なる２種類の不溶性担体粒子群を含み、一方の不溶性担体粒子群に含まれる不溶性担体粒子は、ポリクローナル抗体およびモノクローナル抗体を担持し、他方の不溶性担体粒子群に含まれる不溶性担体粒子は、ポリクローナル抗体およびモノクローナル抗体の少なくとも一方の抗体を担持する構成とする。前者が小さい平均粒子径の不溶性担体粒子群であり、後者が大きい平均粒子径の不溶性担体粒子群であることが好ましい。
PCT/JP2008/071121 2007-11-21 2008-11-20 測定試薬、それを用いた免疫比濁法および検体分析用具 WO2009066731A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009506462A JPWO2009066731A1 (ja) 2007-11-21 2008-11-20 測定試薬、それを用いた免疫比濁法および検体分析用具
EP08851516A EP2146207A4 (en) 2007-11-21 2008-11-20 MEASUREMENT REAGENT, ITS USE IN IMMUNO NEPHELOMETRY, AND ANALYSIS ANALYSIS INSTRUMENT
CN200880017706A CN101680891A (zh) 2007-11-21 2008-11-20 测定试剂、使用其的免疫比浊法和待测物分析用具
US12/599,153 US20100240150A1 (en) 2007-11-21 2008-11-20 Measuring reagent and turbidimetric immunoassay and sample analysis tool using the same

Applications Claiming Priority (2)

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JP2007302182 2007-11-21
JP2007-302182 2007-11-21

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WO2009066731A1 true WO2009066731A1 (ja) 2009-05-28

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US (1) US20100240150A1 (ja)
EP (1) EP2146207A4 (ja)
JP (1) JPWO2009066731A1 (ja)
CN (1) CN101680891A (ja)
WO (1) WO2009066731A1 (ja)

Cited By (4)

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CN102628868A (zh) * 2011-12-30 2012-08-08 北京九强生物技术股份有限公司 检测非对称二甲基精氨酸含量的胶乳增强免疫比浊法试剂盒
CN104155458A (zh) * 2013-11-27 2014-11-19 新昌县美迪生物科技有限公司 人绒毛膜促性腺激素定量检测试剂盒及其用途
CN106053828A (zh) * 2016-05-26 2016-10-26 安徽伊普诺康生物技术股份有限公司 一种测定全量程‑c反应蛋白的试剂盒及其制备方法
WO2021199178A1 (ja) * 2020-03-30 2021-10-07 デンカ生研株式会社 ラテックス凝集法による目的物質の測定方法、およびその試薬

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CN101881777B (zh) * 2010-06-30 2013-10-02 深圳市国赛生物技术有限公司 无需对全血样本进行预处理的超敏c反应蛋白检测方法及试剂盒
CN102175871B (zh) * 2010-12-30 2014-05-07 北京九强生物技术股份有限公司 双胶乳法测定血清或尿液中游离轻链的液体双试剂试剂盒
CN102175870B (zh) * 2011-02-24 2013-07-31 南京基蛋生物科技有限公司 一种胶乳微球交联方式增加胶乳试剂灵敏度的方法
CN102353770B (zh) * 2011-06-03 2013-11-06 宁波美康生物科技股份有限公司 胱氨酸蛋白酶抑制剂c检测试剂盒
CN102590524B (zh) * 2011-12-30 2016-01-06 北京九强生物技术股份有限公司 中性粒细胞明胶酶相关脂质运载蛋白检测试剂盒
CN102628867B (zh) * 2011-12-30 2016-03-23 北京九强生物技术股份有限公司 双抗体胶乳增强视黄醇结合蛋白检测试剂盒
CN102636653A (zh) * 2012-04-19 2012-08-15 上海蓝怡科技有限公司 复合胶乳粒子包被胱抑素c检测试剂盒
CN102866256B (zh) * 2012-04-23 2015-05-20 深圳市希莱恒医用电子有限公司 一种超敏c反应蛋白检测方法及检测试剂
CN102662059B (zh) * 2012-05-11 2014-08-13 北京美康生物技术研究中心 一种用于测定幽门螺杆菌抗体的胶乳增强免疫比浊试剂盒及其制备方法和应用
CN105158476A (zh) * 2015-06-03 2015-12-16 南京闻智生物科技有限公司 一种全量程c反应蛋白胶乳增强免疫比浊检测试剂盒
CN105738617B (zh) * 2016-04-01 2018-05-04 武汉生之源生物科技股份有限公司 一种胱抑素c胶乳增强比浊检测试剂盒及其用途
EP3239709B1 (en) * 2016-04-25 2019-06-05 ARKRAY, Inc. Method of analyzing glycated protein; use of analysis reagent, analysis kit, and test piece for analysis
CN105911297B (zh) * 2016-07-07 2018-03-16 宏葵生物（中国）有限公司 胶乳增强免疫比浊法检测心型脂肪酸结合蛋白的试剂盒
CN106324239B (zh) * 2016-07-28 2018-06-19 武汉景川诊断技术股份有限公司 C-反应蛋白免疫胶乳微球制备方法及应用
CN106290822B (zh) * 2016-07-28 2018-06-19 武汉景川诊断技术股份有限公司 D-二聚体免疫胶乳微球制备方法及应用
CN107656069A (zh) * 2017-09-28 2018-02-02 宁波普瑞柏生物技术股份有限公司 全血中全量程c‑反应蛋白定量检测试剂及方法
CN107561292A (zh) * 2017-09-30 2018-01-09 安徽伊普诺康生物技术股份有限公司 一种孕酮检测试剂盒及其使用方法
CN107727871A (zh) * 2017-09-30 2018-02-23 安徽伊普诺康生物技术股份有限公司 一种孕酮检测试剂盒的制备方法
CN111999505A (zh) * 2020-08-12 2020-11-27 北京安图生物工程有限公司 检测抗链球菌溶血素o的试剂及其制备方法
CN113092790B (zh) * 2021-04-02 2023-12-15 三诺生物传感股份有限公司 一种降钙素原的检测试剂盒及其制备方法
CN112858698B (zh) * 2021-04-25 2021-11-09 北京沃森赛瑟生物技术有限公司 一种d-二聚体胶乳增强免疫比浊试剂盒及其制备方法

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TAKASHI KOBAYASHI: "'LZ Test 'Eiken' CRP-HG' no Kihon Sieno", JOURNAL OF CLINICAL LABORATORY INSTRUMENTS AND REAGENTS, vol. 26, no. 6, 2003, pages 497 - 504, XP008142117 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102628868A (zh) * 2011-12-30 2012-08-08 北京九强生物技术股份有限公司 检测非对称二甲基精氨酸含量的胶乳增强免疫比浊法试剂盒
CN102628868B (zh) * 2011-12-30 2014-09-17 北京九强生物技术股份有限公司 检测非对称二甲基精氨酸含量的胶乳增强免疫比浊法试剂盒
CN104155458A (zh) * 2013-11-27 2014-11-19 新昌县美迪生物科技有限公司 人绒毛膜促性腺激素定量检测试剂盒及其用途
CN106053828A (zh) * 2016-05-26 2016-10-26 安徽伊普诺康生物技术股份有限公司 一种测定全量程‑c反应蛋白的试剂盒及其制备方法
WO2021199178A1 (ja) * 2020-03-30 2021-10-07 デンカ生研株式会社 ラテックス凝集法による目的物質の測定方法、およびその試薬

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EP2146207A1 (en) 2010-01-20
JPWO2009066731A1 (ja) 2011-04-07
EP2146207A4 (en) 2010-12-29
US20100240150A1 (en) 2010-09-23
CN101680891A (zh) 2010-03-24

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