WO2009065586A2 - Verfahren und messeinrichtung zur erhebung hinsichtlich der konzentration eines stoffes in einem untersuchungsbereich indikativer signale, insbesondere aus vitalem gewebe - Google Patents

Verfahren und messeinrichtung zur erhebung hinsichtlich der konzentration eines stoffes in einem untersuchungsbereich indikativer signale, insbesondere aus vitalem gewebe Download PDF

Info

Publication number
WO2009065586A2
WO2009065586A2 PCT/EP2008/009827 EP2008009827W WO2009065586A2 WO 2009065586 A2 WO2009065586 A2 WO 2009065586A2 EP 2008009827 W EP2008009827 W EP 2008009827W WO 2009065586 A2 WO2009065586 A2 WO 2009065586A2
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
light
spectrometer
examined
heating
Prior art date
Application number
PCT/EP2008/009827
Other languages
German (de)
English (en)
French (fr)
Inventor
Holger Jungmann
Michael Schietzel
Original Assignee
Mbr Optical Systems Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mbr Optical Systems Gmbh & Co. Kg filed Critical Mbr Optical Systems Gmbh & Co. Kg
Priority to DE112008003122T priority Critical patent/DE112008003122A5/de
Priority to EP08852593A priority patent/EP2283341A2/de
Priority to JP2010534406A priority patent/JP2011522214A/ja
Publication of WO2009065586A2 publication Critical patent/WO2009065586A2/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance

Definitions

  • the invention is directed to a method and a measuring device for collecting signals which as such provide information about the concentration of a substance, in particular within a vital tissue area.
  • the invention has for its object to provide solutions by which measured values can be generated by means of a spectrometric measurement, which in addition to the detection of certain substances provide more comprehensive information, in particular with regard to the amount or concentration of these substances in the tissue section in particular a capillary.
  • This object is achieved according to the invention by a method for generating spectrometric measurement signals in which:
  • Light is coupled into a vital tissue region to be examined
  • Tissue region is fed to a spectrometer device, and the spectrometer device generates measurement signals which as such are the intensity of the
  • Substances in the tissue section is calculated.
  • the active change in the temperature of the tissue region to be examined is effected by irradiation of light.
  • This light is preferably generated by a heat radiator, in particular a heated light source.
  • light in the near infrared range is suitable for the detection of blood constituents.
  • tissue temperature values associated with the respectively recorded spectra can be calculated in particular on the basis of the energy input made in the course of the heating phase, or they can also be measured.
  • the measurement of the temperature can be carried out in particular under the direct evaluation of certain spectral ranges of the recorded spectrum.
  • the heating of the tissue region or the sample to be examined is preferably carried out in pulses.
  • the pulse interval can be determined such that, as part of the subsequent heating pulses, a successive heating of the tissue section to be examined is achieved.
  • a corresponding spectrum is detected and stored in terms of data technology.
  • the present invention is not limited to applications for determining the concentration of substances in vital tissue.
  • the inventive approach for determining the concentration of substances indicative values based on an actively induced thermal distortion can also be applied to other samples, in particular for the in vitro analysis of substance concentrations.
  • FIG. 1 shows a sketch to illustrate a measuring arrangement according to the invention for the subsequent generation of substance spectra, in each case with stepwise heating of the tissue section to be examined,
  • Figure 2 is a diagram illustrating the variation of the absorption coefficient of a substance at different tissue temperatures
  • FIG. 3 shows a diagram for illustrating the successive increase in temperature of the examined tissue region for the active induction of the concentration-indicative changes of the spectra.
  • FIG. 1 shows in a greatly simplified manner a measuring arrangement for generating spectrometric measuring signals.
  • This measuring arrangement comprises a light source 1, preferably embodied as an LED light source, and a receiver system 2 symbolized here only for the purpose of illustration as a prism, by means of which the light L 1 emerging from a sample P can be detected.
  • the receiver system 2 comprises a spectrometer device, by means of which measurement signals are generated, which as such represent the intensity of the remission light L 1 associated with the wavelength.
  • the measuring arrangement according to the invention is operated in such a way that the sample P is heated stepwise over a sufficiently long period of time, several spectra being recorded as part of this heating of the sample P.
  • the concentration of certain substances can be calculated on the basis of a correlation approach.
  • the calculation of the concentrations of these substances is carried out using a phenomenon that consists in the fact that the temperature dependence of the change in the optical density of certain substances within a studied overall system is also dependent on the concentration of the substance in that overall system.
  • the tissue to be examined is heated to include the substance to be detected and at the same time the absorption spectrum is measured.
  • the absorption coefficient A is given by:
  • the concentration of S can be determined.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
PCT/EP2008/009827 2007-11-20 2008-11-20 Verfahren und messeinrichtung zur erhebung hinsichtlich der konzentration eines stoffes in einem untersuchungsbereich indikativer signale, insbesondere aus vitalem gewebe WO2009065586A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE112008003122T DE112008003122A5 (de) 2007-11-20 2008-11-20 Verfahren und Messeinrichtung zur Erhebung hinsichtlich der Konzentration eines Stoffes in einem Untersuchungsbereich indikativer Signale, insbesondere aus vitalem Gewebe
EP08852593A EP2283341A2 (de) 2007-11-20 2008-11-20 Verfahren und messeinrichtung zur erhebung hinsichtlich der konzentration eines stoffes in einem untersuchungsbereich indikativer signale, insbesondere aus vitalem gewebe
JP2010534406A JP2011522214A (ja) 2007-11-20 2008-11-20 被験領域、特に生体組織内の被験領域における物質濃度を示す信号を収集する方法および測定器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007055590.5 2007-11-20
DE102007055590 2007-11-20

Publications (1)

Publication Number Publication Date
WO2009065586A2 true WO2009065586A2 (de) 2009-05-28

Family

ID=40473402

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/009827 WO2009065586A2 (de) 2007-11-20 2008-11-20 Verfahren und messeinrichtung zur erhebung hinsichtlich der konzentration eines stoffes in einem untersuchungsbereich indikativer signale, insbesondere aus vitalem gewebe

Country Status (5)

Country Link
EP (1) EP2283341A2 (ja)
JP (1) JP2011522214A (ja)
KR (1) KR20100110305A (ja)
DE (2) DE112008003122A5 (ja)
WO (1) WO2009065586A2 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5468089B2 (ja) * 2009-12-18 2014-04-09 パナソニック株式会社 成分濃度計、成分濃度測定方法、出荷検査システム、及び健康管理システム
WO2023090010A1 (ja) * 2021-11-17 2023-05-25 パナソニックＩｐマネジメント株式会社 赤外線センサ、センシングシステム、及び赤外線のセンシング方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102669993B1 (ko) * 2018-10-17 2024-05-27 삼성전자주식회사 대상체의 온도 변화에 따른 스펙트럼 처리 장치 및 방법

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5115133A (en) * 1990-04-19 1992-05-19 Inomet, Inc. Testing of body fluid constituents through measuring light reflected from tympanic membrane
FI96993C (fi) * 1992-01-30 1996-09-25 Vaisala Oy Kalibrointimenetelmä kaasujen pitoisuuden mittausta varten
JPH07284490A (ja) * 1994-02-22 1995-10-31 Minolta Co Ltd グルコース濃度測定装置
JPH0956702A (ja) * 1995-08-18 1997-03-04 Minolta Co Ltd 無侵襲血中成分濃度測定装置
US6072180A (en) * 1995-10-17 2000-06-06 Optiscan Biomedical Corporation Non-invasive infrared absorption spectrometer for the generation and capture of thermal gradient spectra from living tissue
JPH1033512A (ja) * 1996-07-26 1998-02-10 Hitachi Ltd 無侵襲生化学計測装置
JPH11123195A (ja) * 1997-08-22 1999-05-11 Kdk Corp 生体測定方法及び装置
JPH11155840A (ja) * 1997-11-27 1999-06-15 Matsushita Electric Ind Co Ltd 血糖計
JP3798550B2 (ja) * 1998-04-16 2006-07-19 株式会社資生堂 皮膚中の成分の定量方法及び定量装置
JP2000051184A (ja) * 1999-08-09 2000-02-22 Mitsui Mining & Smelting Co Ltd 光学的血糖値非破壊測定装置
JP4362936B2 (ja) * 2000-04-25 2009-11-11 パナソニック電工株式会社 生体中のグルコース濃度の測定装置
DE10027100C2 (de) * 2000-05-31 2002-08-08 Klaus Mueller-Dethlefs Verfahren und Vorrichtung zum Nachweisen von Substanzen in Körperflüssigkeiten
US7167734B2 (en) * 2001-04-13 2007-01-23 Abbott Laboratories Method for optical measurements of tissue to determine disease state or concentration of an analyte
DE10129754A1 (de) * 2001-06-20 2003-01-02 Holger Jungmann Verfahren und Vorrichtung zur Erfassung von Stoffen in vitalem Gewebe
US20050054908A1 (en) * 2003-03-07 2005-03-10 Blank Thomas B. Photostimulation method and apparatus in combination with glucose determination
JP2003265443A (ja) * 2002-03-15 2003-09-24 Shimadzu Corp 無侵襲生体計測装置
US20040132167A1 (en) * 2003-01-06 2004-07-08 Peter Rule Cartridge lance
JP2004321368A (ja) * 2003-04-23 2004-11-18 Olympus Corp グルコース濃度測定装置
JP2004321574A (ja) * 2003-04-25 2004-11-18 Olympus Corp グルコース濃度測定装置
JP3566277B1 (ja) * 2003-06-23 2004-09-15 株式会社日立製作所 血糖値測定装置
JP2005147896A (ja) * 2003-11-17 2005-06-09 Kagawa Univ 混合溶液成分の濃度測定方法および濃度測定装置
JP4880985B2 (ja) * 2005-11-30 2012-02-22 東芝メディカルシステムズ株式会社 グルコースの非侵襲性測定法及びグルコースの非侵襲性測定装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5468089B2 (ja) * 2009-12-18 2014-04-09 パナソニック株式会社 成分濃度計、成分濃度測定方法、出荷検査システム、及び健康管理システム
WO2023090010A1 (ja) * 2021-11-17 2023-05-25 パナソニックＩｐマネジメント株式会社 赤外線センサ、センシングシステム、及び赤外線のセンシング方法

Also Published As

Publication number Publication date
KR20100110305A (ko) 2010-10-12
DE102008058294B3 (de) 2011-08-25
DE112008003122A5 (de) 2010-09-23
EP2283341A2 (de) 2011-02-16
JP2011522214A (ja) 2011-07-28

Similar Documents

Publication Publication Date Title
Marques et al. Heat-induced bone diagenesis probed by vibrational spectroscopy
EP3037805B1 (en) Method for measuring a spectral sample response
EP1965193B1 (de) Verfahren und Vorrichtung zur Ermittlung des Alkoholgehaltes von Flüssigkeiten
DE3137658C2 (de) Vorrichtung zur Messung der Konzentration eines IR-, NIR-, VIS- oder UV-Strahlung absorbierenden Gases in einer Gasmatrix
KR101423988B1 (ko) 레이저 플라즈마 스펙트럼을 이용한 시료 내 측정 대상 원소의 정량 분석 방법
DE69125574T2 (de) Vorrichtung zur Auswertung fluoreszenzmarkierter Gelelektrophoresemuster
Lambert et al. Raman analysis of multilayer automotive paints in forensic science: measurement variability and depth profile
DE102011108180B4 (de) Verfahren und Vorrichtung zum Identifizieren eines photolumineszierenden Materials
DE102011055272A1 (de) Verfahren zur Bestimmung eines relaxationszeitabhängigen Parameters zu einem System
WO2000052449A2 (de) Vorrichtung und verfahren zur simultanen in-situ-bestimmung der teilchengrösse und massenkonzentration von fluidgetragenen partikeln
Lauwers et al. In situ Raman mapping of art objects
DE102008058294B3 (de) Verfahren und Messeinrichtung zur Erhebung hinsichtlich der Konzentration eines Stoffes in einem Untersuchungsbereich indikativer Signale, insbesondere aus vitalem Gewebe
Tempesta et al. Standardless, minimally destructive chemical analysis of red beryls by means of Laser Induced Breakdown Spectroscopy
DE102006010100B4 (de) Vorrichtung und Verfahren zur spektroskopischen Messung
EP4028793B1 (de) Detektorvorrichtung und verfahren zur fernanalyse von stoffen sowie mobiles sensorsystem
Angeyo et al. Principal component analysis‐assisted energy dispersive X‐ray fluorescence spectroscopy for non‐invasive quality assurance characterization of complex matrix materials
Sowoidnich et al. Shifted excitation Raman difference spectroscopy for soil component identification and soil carbonate determination in the presence of strong fluorescence interference
DE102005036146A1 (de) Anordnung zur optischen Flammenprüfung
DE19708462A1 (de) Verfahren und Vorrichtung zur zeitaufgelösten optischen Spektralanalyse von laserinduzierten Mikroplasmen
US4692875A (en) Metal alloy identifier
Aalders et al. Investigating the age of blood traces: How close are we to finding the holy grail of forensic science?
EP0786659A1 (de) Verfahren und Vorrichtung zur Atomabsorptionsspektroskopie
AT518433B1 (de) Spektrometer und Verfahren zur Untersuchung der Inhaltsstoffe eines Fluids
WO2018122319A1 (de) Vorrichtung und verfahren zur nicht-invasiven bestimmung von analyten
DE4028408C2 (de) Verfahren zur berührungslosen Temperaturmessung

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08852593

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2010534406

Country of ref document: JP

ENP Entry into the national phase in:

Ref document number: 20107013744

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2008852593

Country of ref document: EP

REF Corresponds to

Ref document number: 112008003122

Country of ref document: DE

Date of ref document: 20100923

Kind code of ref document: P