WO2009054091A1 - ガストリン放出ペプチド前駆体に対する抗体及びその使用 - Google Patents

ガストリン放出ペプチド前駆体に対する抗体及びその使用 Download PDF

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Publication number
WO2009054091A1
WO2009054091A1 PCT/JP2008/002716 JP2008002716W WO2009054091A1 WO 2009054091 A1 WO2009054091 A1 WO 2009054091A1 JP 2008002716 W JP2008002716 W JP 2008002716W WO 2009054091 A1 WO2009054091 A1 WO 2009054091A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
sample
releasing peptide
directed against
antibody directed
Prior art date
Application number
PCT/JP2008/002716
Other languages
English (en)
French (fr)
Inventor
Katsumi Aoyagi
Yukiji Izawa
Original Assignee
Advanced Life Science Institute, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Life Science Institute, Inc. filed Critical Advanced Life Science Institute, Inc.
Priority to EP08841363.8A priority Critical patent/EP2214016B1/en
Priority to US12/739,952 priority patent/US8609424B2/en
Priority to ES08841363.8T priority patent/ES2523588T3/es
Priority to JP2009537894A priority patent/JP5391071B2/ja
Priority to KR1020107006037A priority patent/KR101525127B1/ko
Priority to CN200880111723.1A priority patent/CN102084249B/zh
Priority to CA2703787A priority patent/CA2703787C/en
Publication of WO2009054091A1 publication Critical patent/WO2009054091A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/5758—Gastrin releasing peptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

　測定値のばらつきや検体の取扱いなどの作業上の制約などの問題を持たない、高感度の新しいＰｒｏＧＲＰの測定法を提供する。 　配列番号１に示されるアミノ酸配列の４７－６８番目のアミノ酸配列によって提示されるエピトープを認識する２種以上の異なる抗体を用いて、ガストリン放出ペプチド前駆体及び／又はその分解物を測定する方法。本発明の方法は、従来の測定法よりも短時間で、より少量の検体試料から、より高い検出感度をもって、冷蔵保存された検体を対象にしてＰｒｏＧＲＰまたはその分解物を検出することができる。
PCT/JP2008/002716 2007-10-26 2008-09-29 ガストリン放出ペプチド前駆体に対する抗体及びその使用 WO2009054091A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP08841363.8A EP2214016B1 (en) 2007-10-26 2008-09-29 Antibody directed against pro-gastrin releasing peptide, and use thereof
US12/739,952 US8609424B2 (en) 2007-10-26 2008-09-29 Antibody directed against pro-gastrin releasing peptide, and use thereof
ES08841363.8T ES2523588T3 (es) 2007-10-26 2008-09-29 Anticuerpo dirigido contra el péptido liberador de gastrina y uso del mismo
JP2009537894A JP5391071B2 (ja) 2007-10-26 2008-09-29 ガストリン放出ペプチド前駆体に対する抗体及びその使用
KR1020107006037A KR101525127B1 (ko) 2007-10-26 2008-09-29 가스트린　방출　펩타이드　전구체에　대한　항체　및　그의　용도
CN200880111723.1A CN102084249B (zh) 2007-10-26 2008-09-29 针对胃泌素释放肽前体的抗体及其应用
CA2703787A CA2703787C (en) 2007-10-26 2008-09-29 Antibody directed against pro-gastrin releasing peptide, and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007278843 2007-10-26
JP2007-278843 2007-10-26

Publications (1)

Publication Number Publication Date
WO2009054091A1 true WO2009054091A1 (ja) 2009-04-30

Family

ID=40579201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002716 WO2009054091A1 (ja) 2007-10-26 2008-09-29 ガストリン放出ペプチド前駆体に対する抗体及びその使用

Country Status (8)

Country Link
US (1) US8609424B2 (ja)
EP (1) EP2214016B1 (ja)
JP (1) JP5391071B2 (ja)
KR (1) KR101525127B1 (ja)
CN (1) CN102084249B (ja)
CA (1) CA2703787C (ja)
ES (1) ES2523588T3 (ja)
WO (1) WO2009054091A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015129361A1 (ja) * 2014-02-26 2015-09-03 コニカミノルタ株式会社 表面プラズモン励起増強蛍光分光測定用センサーチップ
CN114644710A (zh) * 2022-03-16 2022-06-21 中国辐射防护研究院 一种抗前胃泌素释放肽单链抗体及其制备方法与用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104845975A (zh) * 2015-05-29 2015-08-19 郑州大学 小细胞肺癌标志物胃泌素释放肽前体多肽片段的dna核酸适体
CN108279307B (zh) * 2018-01-30 2021-01-26 郑州安图生物工程股份有限公司 保护和稳定血清或血浆中胃泌素释放肽前体的采血管
CN108982858B (zh) * 2018-07-05 2021-06-15 陕西师范大学 一种基于单克隆抗体检测人proGRP的双夹心ELISA试剂盒
CN111349160B (zh) * 2018-12-24 2021-12-03 东莞市朋志生物科技有限公司 一种抗人胃泌素释放肽前体的重组抗体
CN113583124B (zh) * 2021-06-16 2023-12-15 中国辐射防护研究院 一种抗前胃泌素释放肽单克隆抗体及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0698794A (ja) 1992-06-12 1994-04-12 Tonen Corp ヒトガストリン放出ペプチド前駆体に対する抗体及びその使用
EP0811683A1 (en) * 1996-06-03 1997-12-10 Ken Yamaguchi Antibodies to human gastrin-releasing peptide precursor and use thereof
WO2006117994A1 (ja) 2005-04-13 2006-11-09 Advanced Life Science Institute, Inc. ガストリン放出ペプチド前駆体に対する抗体およびその使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
CA2089212C (en) * 1992-06-12 2004-01-20 Ken Yamaguchi Antibodies to human gastrin-releasing peptide precusor and use thereof
US5468494A (en) * 1993-11-12 1995-11-21 Aphton Corp. Immunogenic compositions against human gastrin 17
EP1191096B1 (en) * 1999-06-28 2011-10-12 Yusuke Nakamura Ovel protein and dna thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0698794A (ja) 1992-06-12 1994-04-12 Tonen Corp ヒトガストリン放出ペプチド前駆体に対する抗体及びその使用
JP3210994B2 (ja) 1992-06-12 2001-09-25 株式会社先端生命科学研究所 ヒトガストリン放出ペプチド前駆体に対する抗体及びその使用
EP0811683A1 (en) * 1996-06-03 1997-12-10 Ken Yamaguchi Antibodies to human gastrin-releasing peptide precursor and use thereof
WO2006117994A1 (ja) 2005-04-13 2006-11-09 Advanced Life Science Institute, Inc. ガストリン放出ペプチド前駆体に対する抗体およびその使用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CANCER RESEARCH, vol. 54, 1994, pages 2136 - 2140
HOLST ET AL., J. CLIN. ONCOL., vol. 7, 1989, pages 1831 - 1838
RINSHO KENSA, vol. 39, 1995, pages 981 - 986
See also references of EP2214016A4
SPINDEL ET AL., MOL. ENDOCRINOL., vol. 1, 1987, pages 224 - 232

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015129361A1 (ja) * 2014-02-26 2015-09-03 コニカミノルタ株式会社 表面プラズモン励起増強蛍光分光測定用センサーチップ
JPWO2015129361A1 (ja) * 2014-02-26 2017-03-30 コニカミノルタ株式会社 表面プラズモン励起増強蛍光分光測定用センサーチップ
CN114644710A (zh) * 2022-03-16 2022-06-21 中国辐射防护研究院 一种抗前胃泌素释放肽单链抗体及其制备方法与用途

Also Published As

Publication number Publication date
EP2214016A1 (en) 2010-08-04
CA2703787A1 (en) 2009-04-30
CA2703787C (en) 2016-08-23
JPWO2009054091A1 (ja) 2011-03-03
CN102084249B (zh) 2014-10-29
CN102084249A (zh) 2011-06-01
EP2214016B1 (en) 2014-09-10
ES2523588T3 (es) 2014-11-27
EP2214016A4 (en) 2011-10-19
KR101525127B1 (ko) 2015-06-03
US8609424B2 (en) 2013-12-17
US20100248274A1 (en) 2010-09-30
JP5391071B2 (ja) 2014-01-15
KR20100082764A (ko) 2010-07-19

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