WO2009035092A1 - 新規なポリペプチドおよびその製造方法 - Google Patents

新規なポリペプチドおよびその製造方法 Download PDF

Info

Publication number
WO2009035092A1
WO2009035092A1 PCT/JP2008/066568 JP2008066568W WO2009035092A1 WO 2009035092 A1 WO2009035092 A1 WO 2009035092A1 JP 2008066568 W JP2008066568 W JP 2008066568W WO 2009035092 A1 WO2009035092 A1 WO 2009035092A1
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
group
pro
carbonyl group
hyp
Prior art date
Application number
PCT/JP2008/066568
Other languages
English (en)
French (fr)
Inventor
Masao Tanihara
Original Assignee
National University Corporation NARA Institute of Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation NARA Institute of Science and Technology filed Critical National University Corporation NARA Institute of Science and Technology
Priority to EP08830671A priority Critical patent/EP2189476B1/en
Priority to US12/733,621 priority patent/US8357774B2/en
Priority to JP2009532246A priority patent/JP5339534B2/ja
Publication of WO2009035092A1 publication Critical patent/WO2009035092A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Eyeglasses (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

　本発明は、病原体の感染や病原性因子の伝達を生じる危険性や望ましくない副作用を生じる虞がなく、種々の生理活性物質やアパタイト類の担体として有用な新規なポリペプチドおよびその製造方法を提供する。具体的には、本発明は、式：-Pro-X-Gly-（式中、XはProまたはHypを表す）で表されるアミノ酸配列を有するペプチドユニットと、式：-Pro-Hyp(O-Y-Z)-Gly-（式中、Yはカルボニル基、カルボニル基を有するかまたは有しない飽和または不飽和の炭化水素基、または芳香族基を含む、カルボニル基を有するかまたは有しない飽和または不飽和の炭化水素基を表し、Zはカルボキシル基を表す）で表されるアミノ酸配列を有するペプチドユニットとを含むポリペプチドおよびその製造方法を提供する。
PCT/JP2008/066568 2007-09-13 2008-09-12 新規なポリペプチドおよびその製造方法 WO2009035092A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08830671A EP2189476B1 (en) 2007-09-13 2008-09-12 Novel polypeptide and production method thereof
US12/733,621 US8357774B2 (en) 2007-09-13 2008-09-12 Polypeptide and process for producing the same
JP2009532246A JP5339534B2 (ja) 2007-09-13 2008-09-12 新規なポリペプチドおよびその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007238437 2007-09-13
JP2007-238437 2007-09-13

Publications (1)

Publication Number Publication Date
WO2009035092A1 true WO2009035092A1 (ja) 2009-03-19

Family

ID=40452098

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066568 WO2009035092A1 (ja) 2007-09-13 2008-09-12 新規なポリペプチドおよびその製造方法

Country Status (4)

Country Link
US (1) US8357774B2 (ja)
EP (1) EP2189476B1 (ja)
JP (1) JP5339534B2 (ja)
WO (1) WO2009035092A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010125722A1 (ja) * 2009-05-01 2010-11-04 国立大学法人 千葉大学 人工コラーゲンを用いた軟骨培養用基材及び該基材を用いた軟骨再生治療方法
WO2011158864A1 (ja) 2010-06-15 2011-12-22 国立大学法人 奈良先端科学技術大学院大学 レチノール修飾コラーゲン、その製造方法およびそれを含む皮膚外用組成物
JP2012126658A (ja) * 2010-12-13 2012-07-05 Jnc Corp 血小板放出促進剤および血小板放出促進方法
CN102770446A (zh) * 2010-02-26 2012-11-07 奥齿泰种植体股份有限公司 改善成骨细胞分化的寡肽
WO2013002311A1 (ja) * 2011-06-28 2013-01-03 国立大学法人奈良先端科学技術大学院大学 幹細胞培養用基材及びそれを用いた培養方法
JP2014009194A (ja) * 2012-06-29 2014-01-20 Jnc Corp コラーゲン様ポリペプチドの製造方法
CN109069569A (zh) * 2015-12-02 2018-12-21 韩美药品株式会社 使用脂肪酸衍生物的蛋白缀合物及其制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5991624B2 (ja) * 2010-11-26 2016-09-14 国立大学法人東京工業大学 コラーゲン非線維化成形体及びその製造方法
CN109438585B (zh) * 2018-11-14 2021-05-14 北京智飞绿竹生物制药有限公司 一种b型嗜血杆菌多糖的纯化工艺

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1288228A1 (en) * 2001-08-31 2003-03-05 Yoshihiko Nishimura BMP-2-derived peptides having osteogenetic activity and osteogenetic accelerator containing the same
JP2003321500A (ja) * 2002-02-28 2003-11-11 Sentomedo:Kk 新規なポリペプチドおよびその製造方法
JP2004201566A (ja) * 2002-12-25 2004-07-22 Masao Tanihara アポトーシス抑制ペプチド
JP2005060314A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 化粧料
JP2005060315A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 製剤組成物
JP2005058499A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 生体材料
WO2006046569A1 (ja) * 2004-10-26 2006-05-04 National University Corporation NARA Institute of Science and Technology 神経分化促進ペプチド
WO2006098326A1 (ja) * 2005-03-15 2006-09-21 National University Corporation NARA Institute of Science and Technology 生体材料用複合体およびその製造方法
JP2007223981A (ja) * 2006-02-24 2007-09-06 Nara Institute Of Science & Technology ペプチド類の安定化剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005126360A (ja) * 2003-10-23 2005-05-19 Masao Tanihara 新規なポリペプチドで構成されたコラゲナーゼ阻害剤
JP4303137B2 (ja) * 2004-01-23 2009-07-29 株式会社Ｐｈｇ 新規なポリペプチド及びその製造方法
US20070207955A1 (en) * 2006-03-02 2007-09-06 Masao Tanihara Novel polypeptide and process for producing the same, and collagenase inhibitor
US20070207180A1 (en) * 2006-03-02 2007-09-06 Masao Tanihara Synthetic polypeptide-containing bioapplicable material and film-forming material
US20070224251A1 (en) * 2006-03-22 2007-09-27 Masao Tanihara Hemostatic material

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1288228A1 (en) * 2001-08-31 2003-03-05 Yoshihiko Nishimura BMP-2-derived peptides having osteogenetic activity and osteogenetic accelerator containing the same
JP2003321500A (ja) * 2002-02-28 2003-11-11 Sentomedo:Kk 新規なポリペプチドおよびその製造方法
JP2004201566A (ja) * 2002-12-25 2004-07-22 Masao Tanihara アポトーシス抑制ペプチド
JP2005060314A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 化粧料
JP2005060315A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 製剤組成物
JP2005058499A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 生体材料
WO2006046569A1 (ja) * 2004-10-26 2006-05-04 National University Corporation NARA Institute of Science and Technology 神経分化促進ペプチド
WO2006098326A1 (ja) * 2005-03-15 2006-09-21 National University Corporation NARA Institute of Science and Technology 生体材料用複合体およびその製造方法
JP2007223981A (ja) * 2006-02-24 2007-09-06 Nara Institute Of Science & Technology ペプチド類の安定化剤

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010125722A1 (ja) * 2009-05-01 2010-11-04 国立大学法人 千葉大学 人工コラーゲンを用いた軟骨培養用基材及び該基材を用いた軟骨再生治療方法
JP5704344B2 (ja) * 2009-05-01 2015-04-22 国立大学法人 千葉大学 人工コラーゲンを用いた軟骨培養用基材及び該基材を用いた軟骨再生治療方法
JPWO2010125722A1 (ja) * 2009-05-01 2012-10-25 国立大学法人 千葉大学 人工コラーゲンを用いた軟骨培養用基材及び該基材を用いた軟骨再生治療方法
CN102770446B (zh) * 2010-02-26 2014-09-03 奥齿泰种植体股份有限公司 改善成骨细胞分化的寡肽
CN102770446A (zh) * 2010-02-26 2012-11-07 奥齿泰种植体股份有限公司 改善成骨细胞分化的寡肽
US9238688B2 (en) 2010-06-15 2016-01-19 National University Corporation NARA Institute of Science and Technology Retinol-modified collagen, method for producing same, and external composition for skin containing same
WO2011158864A1 (ja) 2010-06-15 2011-12-22 国立大学法人 奈良先端科学技術大学院大学 レチノール修飾コラーゲン、その製造方法およびそれを含む皮膚外用組成物
JP2012126658A (ja) * 2010-12-13 2012-07-05 Jnc Corp 血小板放出促進剤および血小板放出促進方法
WO2013002311A1 (ja) * 2011-06-28 2013-01-03 国立大学法人奈良先端科学技術大学院大学 幹細胞培養用基材及びそれを用いた培養方法
JP2014009194A (ja) * 2012-06-29 2014-01-20 Jnc Corp コラーゲン様ポリペプチドの製造方法
CN109069569A (zh) * 2015-12-02 2018-12-21 韩美药品株式会社 使用脂肪酸衍生物的蛋白缀合物及其制备方法
JP2019501144A (ja) * 2015-12-02 2019-01-17 ハンミ ファーマシューティカル カンパニー リミテッド 脂肪酸誘導体を用いたタンパク質結合体及びその製造方法
CN109069569B (zh) * 2015-12-02 2023-02-14 韩美药品株式会社 使用脂肪酸衍生物的蛋白缀合物及其制备方法

Also Published As

Publication number Publication date
EP2189476B1 (en) 2013-02-13
JP5339534B2 (ja) 2013-11-13
EP2189476A4 (en) 2010-09-01
JPWO2009035092A1 (ja) 2010-12-24
US8357774B2 (en) 2013-01-22
EP2189476A1 (en) 2010-05-26
US20100286368A1 (en) 2010-11-11

Similar Documents

Publication Publication Date Title
WO2009035092A1 (ja) 新規なポリペプチドおよびその製造方法
CY1113684T1 (el) Anti-mikρobiaka πεπτιδια που περιλαμβανουν μια αργινινη (arginine)- kai/ή λυσινη (lysine)- που περιεχουν υποκινητη
MX2008014101A (es) Acidos carboxilicos sustituidos con 4,5-difenil-pirimidinilamino, metodo para su produccion y su uso como medicamentos.
EP2455460A3 (en) Lipase variants for pharmaceutical use
WO2009114702A3 (en) Recombinant production of authentic human proteins using human cell expression systems
MY148483A (en) 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
SG170116A1 (en) Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
MX2020001231A (es) Composiciones que contienen, metodos que incluyen, y usos de derivados de dolastatina enlazados a aminoacidos no naturales.
NZ597692A (en) Anti-IGF antibodies
EP2810661A3 (en) Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
NZ595037A (en) Inhibition of biofilm organisms by combination of cysteamine and repetitive peptides
WO2014105788A3 (en) Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
IN2014CN02050A (ja)
EP3578193A3 (en) Peptides and their use
SG162744A1 (en) Stable active ingredient complex of salts of the o-acetylsalicylic acid with basic amino acids and glycine
WO2007039231A3 (en) Method of producing a modified (poly)peptide
WO2007097903A3 (en) Hiv fusion inhibitor peptides with improved biological properties
EP2998401A3 (en) Plants having enhanced yield-related traits and a method for making the same
WO2007093848A3 (en) Crystalline enoyl-(acyl-carrier-protein) reductase from heliobacter pylori
WO2008113536A8 (en) Neurotrophic peptides
MX2008004899A (es) Compuestos y métodos para partículas de condensado de ácido ribonucleico de péptido para terapéuticos de arn.
WO2010057242A3 (de) Vakzin
WO2008047370A3 (en) Compositions and methods for inducing angiogenesis
WO2010057275A8 (en) Cyclic peptides and uses thereof
WO2008126783A1 (ja) ジペプチドの製造法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08830671

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009532246

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 12733621

Country of ref document: US

Ref document number: 2008830671

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE