WO2009028248A1 - 環状へプタペプチド及びその用途 - Google Patents

環状へプタペプチド及びその用途 Download PDF

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Publication number
WO2009028248A1
WO2009028248A1 PCT/JP2008/060486 JP2008060486W WO2009028248A1 WO 2009028248 A1 WO2009028248 A1 WO 2009028248A1 JP 2008060486 W JP2008060486 W JP 2008060486W WO 2009028248 A1 WO2009028248 A1 WO 2009028248A1
Authority
WO
WIPO (PCT)
Prior art keywords
same
cyclic heptapeptide
inhibitor
novel cyclic
heptapeptide
Prior art date
Application number
PCT/JP2008/060486
Other languages
English (en)
French (fr)
Inventor
Daisuke Uemura
Kenichiro Shimokawa
Takaaki Iwase
Kaoru Yamada
Original Assignee
National University Corporation Nagoya University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Nagoya University filed Critical National University Corporation Nagoya University
Priority to JP2009530011A priority Critical patent/JP4441621B2/ja
Priority to EP08765299A priority patent/EP2194062B1/en
Priority to US12/675,485 priority patent/US8481484B2/en
Publication of WO2009028248A1 publication Critical patent/WO2009028248A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

　前駆脂肪細胞の分化抑制剤又は脂肪細胞の脂肪蓄積抑制剤として有用な新規環状ヘプタペプチド及びその用途を提供すること。以下の式で表される新規な環状へプタペプチドが提供される。［化１］ 但し、式中のRはCH3、CH2CH(CH3)2、CH2OCH2C6H5、CH(OH)CH3又はCH2OHである。
PCT/JP2008/060486 2007-08-27 2008-06-06 環状へプタペプチド及びその用途 WO2009028248A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009530011A JP4441621B2 (ja) 2007-08-27 2008-06-06 環状へプタペプチド及びその用途
EP08765299A EP2194062B1 (en) 2007-08-27 2008-06-06 Cyclic heptapeptide and use of the same
US12/675,485 US8481484B2 (en) 2007-08-27 2008-06-06 Cyclic heptapeptide and use of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-220131 2007-08-27
JP2007220131 2007-08-27

Publications (1)

Publication Number Publication Date
WO2009028248A1 true WO2009028248A1 (ja) 2009-03-05

Family

ID=40386977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060486 WO2009028248A1 (ja) 2007-08-27 2008-06-06 環状へプタペプチド及びその用途

Country Status (4)

Country Link
US (1) US8481484B2 (ja)
EP (1) EP2194062B1 (ja)
JP (1) JP4441621B2 (ja)
WO (1) WO2009028248A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230391827A1 (en) * 2020-10-30 2023-12-07 University Of Utah Research Foundation Antibacterial cyclopeptides targeting acinetobacter and other gram-negative pathogens

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU517198A1 (ru) 1974-12-17 1979-01-25 Всесоюзный научно-исследовательский институт фитопатологии Способ получени противогрибкового антибиотика
JPH06293796A (ja) 1993-03-24 1994-10-21 Ito Ham Kk 脂肪細胞分化抑制ペプチド及び当該ペプチドを有効成分とする脂肪細胞分化抑制剤
JPH11130656A (ja) 1997-10-24 1999-05-18 Kose Corp 脂肪蓄積抑制剤及びそれを含有する皮膚外用剤
JP2002037738A (ja) 2000-07-25 2002-02-06 Kotobuki Chemical:Kk 脂肪前駆細胞から脂肪細胞への分化抑制剤とこの脂肪細胞への分化抑制剤に用いる活性化乳清及びその活性化乳清の製造方法。
JP2004075640A (ja) 2002-08-22 2004-03-11 Fancl Corp 脂肪細胞分化抑制剤
JP2005220074A (ja) 2004-02-05 2005-08-18 Fancl Corp 脂肪細胞分化抑制剤
JP2006213648A (ja) 2005-02-03 2006-08-17 Fancl Corp 脂肪細胞の脂肪蓄積阻害剤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU517198A1 (ru) 1974-12-17 1979-01-25 Всесоюзный научно-исследовательский институт фитопатологии Способ получени противогрибкового антибиотика
JPH06293796A (ja) 1993-03-24 1994-10-21 Ito Ham Kk 脂肪細胞分化抑制ペプチド及び当該ペプチドを有効成分とする脂肪細胞分化抑制剤
JPH11130656A (ja) 1997-10-24 1999-05-18 Kose Corp 脂肪蓄積抑制剤及びそれを含有する皮膚外用剤
JP2002037738A (ja) 2000-07-25 2002-02-06 Kotobuki Chemical:Kk 脂肪前駆細胞から脂肪細胞への分化抑制剤とこの脂肪細胞への分化抑制剤に用いる活性化乳清及びその活性化乳清の製造方法。
JP2004075640A (ja) 2002-08-22 2004-03-11 Fancl Corp 脂肪細胞分化抑制剤
JP2005220074A (ja) 2004-02-05 2005-08-18 Fancl Corp 脂肪細胞分化抑制剤
JP2006213648A (ja) 2005-02-03 2006-08-17 Fancl Corp 脂肪細胞の脂肪蓄積阻害剤

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ACTA CRYSTALLOGRAPHICA SECTION D, vol. 49, 1993, pages 158 - 167
DAISUKE UEMURA: "Kireaji no yoi tennen yuki bunshi o motomete", 25TH SYMPOSIUM ON MEDICINAL CHEMISTRY ABSTRACTS, 2006, pages 22 *
HALE, K. J.; MANAVIAZAR, S.; DELISSER, V. M., TETRAHEDRON, vol. 50, 1994, pages 9181 - 9188
INTERNATIONAL JOURNAL OF PEPTIDE & PROTEIN RESEARCH, vol. 42, 1993, pages 539 - 549
KEN'ICHIRO SHIMOKAWA ET AL.: "Kawaratake yurai no shibo chikuseki sogai busshitsu ternatin no tanri to kozo", 47TH SYMPOSIUM ON THE CHEMISTRY OF NATURAL PRODUCTS, SYMPOSIUM PAPERS, 2005, pages 607 - 612 *
KEN'ICHIRO SHIMOKAWA ET AL.: "Kawaratake yurai no shibo chikuseki sogai busshitsu", 36TH ANNUAL MEETING OF UNION OF CHEMISTRY-RELATED SOCIETIES, 2005, CHUBU AREA, JAPAN, pages 64 *
PROTEIN NUCLEIC ACID ENZYME, vol. 45, 2000, pages 935 - 940
See also references of EP2194062A4 *
SHIMOKAWA K. ET AL.: "(-)-Ternatin, a highly N-methylated cyclic heptapeptide that inhibits fat accumulation: structure and synthesis", TETRAHEDRON LETTERS, vol. 47, no. 26, 2006, pages 4445 - 4448, XP005458497 *
SHIMOKAWA K. ET AL.: "Convergent synthesis and in vivo inhibitory effect on fat accumulation of (-)-ternatin, a highly N-methylated cyclic peptide", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 16, 15 August 2007 (2007-08-15), pages 4447 - 4449, XP022181844 *
SHIMOKAWA K. ET AL.: "Synthesis and inhibitory effect on fat modified in the beta-OH-D-Leu7 moiety", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 6, no. 1, January 2008 (2008-01-01), pages 58 - 60, XP002598745 *
TETRAHEDRON LETTERS, vol. 47, 2006, pages 4445

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Also Published As

Publication number Publication date
JPWO2009028248A1 (ja) 2010-11-25
EP2194062B1 (en) 2013-03-13
US20100286363A1 (en) 2010-11-11
US8481484B2 (en) 2013-07-09
EP2194062A4 (en) 2010-10-20
EP2194062A1 (en) 2010-06-09
JP4441621B2 (ja) 2010-03-31

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