WO2009014177A1 - ジベンゾフルベン誘導体の淘汰方法 - Google Patents
ジベンゾフルベン誘導体の淘汰方法 Download PDFInfo
- Publication number
- WO2009014177A1 WO2009014177A1 PCT/JP2008/063281 JP2008063281W WO2009014177A1 WO 2009014177 A1 WO2009014177 A1 WO 2009014177A1 JP 2008063281 W JP2008063281 W JP 2008063281W WO 2009014177 A1 WO2009014177 A1 WO 2009014177A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dibenzofulvene
- hydrocarbon solvent
- deprotection
- amino acid
- acid compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Fmoc基で保護されたアミノ酸化合物をアミンと反応させることにより脱保護して得られる、ジベンゾフルベン及び/又はジベンゾフルベンアミン付加体を含む反応混合物を、炭素数5以上の炭化水素溶媒および該炭化水素溶媒に混和しない極性有機溶媒(但し、アミド系有機溶媒を除く。)中で攪拌、分層させ、炭化水素溶媒層を除去することにより、脱保護後に副成するジベンゾフルベン及び/又はジベンゾフルベンアミン付加体を効率的に淘汰することができる。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08791533A EP2181983A4 (en) | 2007-07-25 | 2008-07-24 | METHOD FOR THE SELECTIVE REMOVAL OF A DIBENZOFULVENE DERIVATIVE |
JP2009524510A JP5515738B2 (ja) | 2007-07-25 | 2008-07-24 | ジベンゾフルベン誘導体の淘汰方法 |
US12/692,852 US20100184952A1 (en) | 2007-07-25 | 2010-01-25 | Method for selective removal of dibenzofulvene derivative |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-193153 | 2007-07-25 | ||
JP2007193153 | 2007-07-25 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/692,852 Continuation US20100184952A1 (en) | 2007-07-25 | 2010-01-25 | Method for selective removal of dibenzofulvene derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009014177A1 true WO2009014177A1 (ja) | 2009-01-29 |
Family
ID=40281425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/063281 WO2009014177A1 (ja) | 2007-07-25 | 2008-07-24 | ジベンゾフルベン誘導体の淘汰方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20100184952A1 (ja) |
EP (1) | EP2181983A4 (ja) |
JP (1) | JP5515738B2 (ja) |
WO (1) | WO2009014177A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012029794A1 (ja) | 2010-08-30 | 2012-03-08 | 味の素株式会社 | 分岐鎖含有芳香族化合物 |
WO2013089241A1 (ja) * | 2011-12-15 | 2013-06-20 | 味の素株式会社 | Fmoc基の除去方法 |
CN114585916A (zh) * | 2019-10-15 | 2022-06-03 | 中外制药株式会社 | 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法 |
JP7260725B1 (ja) * | 2021-12-27 | 2023-04-18 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、及び除去剤 |
WO2023127331A1 (ja) * | 2021-12-27 | 2023-07-06 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物 |
WO2024096023A1 (ja) * | 2022-11-01 | 2024-05-10 | 中外製薬株式会社 | ジベンゾフルベンまたはジベンゾフルベン誘導体の除去方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1737889E (pt) | 2004-10-19 | 2010-12-13 | Lonza Ag | Método para síntese de péptidos em fase sólida |
EP2280993A1 (en) * | 2008-05-15 | 2011-02-09 | Novo Nordisk A/S | Purification of peptides prepared by solid phase synthesis |
JP2014517023A (ja) | 2011-06-16 | 2014-07-17 | ロンザ・リミテッド | ペプチドの抽出方法および液相ペプチド合成におけるその使用 |
CN109970609B (zh) * | 2019-03-20 | 2021-05-11 | 广州同隽医药科技有限公司 | 一种组合物及其应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09506336A (ja) * | 1993-09-24 | 1997-06-24 | テラピン テクノロジーズ,インコーポレイテッド | グルタチオンアナログおよびグルタチオン模擬物を含むパラログパネル |
JP2002507576A (ja) * | 1998-03-23 | 2002-03-12 | トリメリス,インコーポレーテッド | ペプチド合成のための方法および組成物 |
WO2003018188A1 (fr) * | 2001-08-24 | 2003-03-06 | Japan Science And Technology Agency | Systeme de solvant multiphase compatible |
JP2005534739A (ja) * | 2002-07-30 | 2005-11-17 | アマシャム バイオサイエンス ユーケイ リミテッド | シアニン染料リポーターを用いたタンパク質の部位特異的標識 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599903A (en) * | 1992-04-03 | 1997-02-04 | Terrapin Technologies, Inc. | Glutathione analogs and paralog panels comprising glutathione mimics |
RU2079491C1 (ru) * | 1995-02-15 | 1997-05-20 | Акционерное общество закрытого типа "Вектор-БиоПродукт" | Nα -2-(4-НИТРОФЕНИЛСУЛЬФОНИЛ)ЭТОКСИКАРБОНИЛ-АМИНОКИСЛОТЫ В КАЧЕСТВЕ Nα -ЗАЩИЩЕННЫХ АМИНОКИСЛОТ ДЛЯ ТВЕРДОФАЗНОГО СИНТЕЗА ПЕПТИДОВ |
US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
CA2453166C (en) * | 2001-04-27 | 2010-01-05 | Japan Science And Technology Corporation | A polymer compound with special optical properties and polymerizing monomer used to synthesize this polymer |
US7256257B2 (en) * | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
GB0217556D0 (en) * | 2002-07-30 | 2002-09-11 | Amersham Biosciences Uk Ltd | Site-specific labelling of proteins using cyanine dye reporters |
HUE036995T2 (hu) * | 2006-05-10 | 2018-08-28 | Sarepta Therapeutics Inc | Az alegységek között kationos kötéssel rendelkezõ oligonukleotid analógok |
-
2008
- 2008-07-24 WO PCT/JP2008/063281 patent/WO2009014177A1/ja active Application Filing
- 2008-07-24 EP EP08791533A patent/EP2181983A4/en not_active Withdrawn
- 2008-07-24 JP JP2009524510A patent/JP5515738B2/ja not_active Expired - Fee Related
-
2010
- 2010-01-25 US US12/692,852 patent/US20100184952A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09506336A (ja) * | 1993-09-24 | 1997-06-24 | テラピン テクノロジーズ,インコーポレイテッド | グルタチオンアナログおよびグルタチオン模擬物を含むパラログパネル |
JP2002507576A (ja) * | 1998-03-23 | 2002-03-12 | トリメリス,インコーポレーテッド | ペプチド合成のための方法および組成物 |
WO2003018188A1 (fr) * | 2001-08-24 | 2003-03-06 | Japan Science And Technology Agency | Systeme de solvant multiphase compatible |
JP2005534739A (ja) * | 2002-07-30 | 2005-11-17 | アマシャム バイオサイエンス ユーケイ リミテッド | シアニン染料リポーターを用いたタンパク質の部位特異的標識 |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012029794A1 (ja) | 2010-08-30 | 2012-03-08 | 味の素株式会社 | 分岐鎖含有芳香族化合物 |
US8546534B2 (en) | 2010-08-30 | 2013-10-01 | Ajinomoto Co., Inc. | Branched chain-containing aromatic compound |
US9499579B2 (en) | 2010-08-30 | 2016-11-22 | Ajinomoto Co., Inc. | Branched chain-containing aromatic compound |
US10711033B2 (en) | 2010-08-30 | 2020-07-14 | Ajinomoto Co., Inc. | Branched chain-containing aromatic compound |
WO2013089241A1 (ja) * | 2011-12-15 | 2013-06-20 | 味の素株式会社 | Fmoc基の除去方法 |
US9334302B2 (en) | 2011-12-15 | 2016-05-10 | Ajinomoto Co., Inc. | Method for removing FMOC group |
CN114585916A (zh) * | 2019-10-15 | 2022-06-03 | 中外制药株式会社 | 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法 |
JP7260725B1 (ja) * | 2021-12-27 | 2023-04-18 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、及び除去剤 |
WO2023127331A1 (ja) * | 2021-12-27 | 2023-07-06 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物 |
WO2024096023A1 (ja) * | 2022-11-01 | 2024-05-10 | 中外製薬株式会社 | ジベンゾフルベンまたはジベンゾフルベン誘導体の除去方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2181983A1 (en) | 2010-05-05 |
JPWO2009014177A1 (ja) | 2010-10-07 |
US20100184952A1 (en) | 2010-07-22 |
JP5515738B2 (ja) | 2014-06-11 |
EP2181983A4 (en) | 2013-01-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009014177A1 (ja) | ジベンゾフルベン誘導体の淘汰方法 | |
ATE388180T1 (de) | Bindemittelgemische aus polyasparaginsäureestern und sulfonatmodifizierten polyisocyanaten | |
GB0803651D0 (en) | A process for purification of trichologalactactosucrose based on direct extraction in organic solvent from reaction mixture followed by evaporative removal | |
WO2007022070A3 (en) | Modified fc molecules | |
Di Gioia et al. | Simple and efficient Fmoc removal in ionic liquid | |
DE502007006970D1 (de) | Verfahren zur Herstellung von Di- und Polyaminen der Diphenylmethanreihe | |
MX271026B (es) | Separacion de una mezcla de sustancias que consiste de cloruro de hidrogeno y fosgeno. | |
PL1948670T3 (pl) | Sposób wydzielania kwasów z chemicznych mieszanin reakcyjnych za pomocą niepolarnych amin trzeciorzędowych | |
WO2008111485A1 (ja) | モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物、核酸、標識物質、核酸検出方法およびキット | |
WO2011126745A3 (en) | Separation system | |
MX2022000665A (es) | Sistema integrado para producir y recuperar biocataliticamente una sustancia organica. | |
JP2011522811A5 (ja) | ||
EP3693377A1 (en) | Method for producing peptide compound | |
UA100125C2 (ru) | Способ выделения и очистки монтелукаста | |
RU2014130277A (ru) | Способ синтеза терапевтических пептидов | |
MX2013005958A (es) | Aminas inhibidas estericamente y metodos asociados. | |
WO2005063799A3 (en) | Peptide synthesis and deprotection with co-solvent | |
WO2008088576A3 (en) | Actinide extraction methods and actinide separation compositions | |
Ruan et al. | Phenylsilane as an active amidation reagent for the preparation of carboxamides and peptides | |
Đud et al. | The utilization of ball milling in synthesis of aryl guanidines through guanidinylation and N-Boc-deprotection sequence | |
WO2007148074A8 (en) | Chemical methods and apparatus | |
WO2007088558A3 (en) | A process for purification of valsartan | |
ATE414733T1 (de) | Verfahren zur rückgewinnung von lösungsmitteln | |
WO2008053037A3 (en) | Process for preparing alkyl aryl sulphonic acids and alkyl aryl sulphonates | |
RU2010115263A (ru) | Способ получения ди- и полиаминов дифенилметанового ряда |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08791533 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2009524510 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008791533 Country of ref document: EP |