WO2009004995A1 - 生理活性物質を定着および発現させる方法 - Google Patents

生理活性物質を定着および発現させる方法 Download PDF

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Publication number
WO2009004995A1
WO2009004995A1 PCT/JP2008/061709 JP2008061709W WO2009004995A1 WO 2009004995 A1 WO2009004995 A1 WO 2009004995A1 JP 2008061709 W JP2008061709 W JP 2008061709W WO 2009004995 A1 WO2009004995 A1 WO 2009004995A1
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WIPO (PCT)
Prior art keywords
active substance
physiologically active
fixing
administered
expressing
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PCT/JP2008/061709
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English (en)
French (fr)
Inventor
Hiroyuki Yoneyama
Kenji Suzuki
Original Assignee
Stelic Institute Of Regenerative Medicine, Stelic Institute & Co.
Niigata University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP18188952.8A priority Critical patent/EP3456357A1/en
Priority to US12/666,983 priority patent/US20100329993A1/en
Priority to EP21163980.2A priority patent/EP3895737A1/en
Priority to EP08790674A priority patent/EP2172226A4/en
Priority to EP15201508.7A priority patent/EP3034095B1/en
Priority to JP2009521604A priority patent/JP5547964B2/ja
Application filed by Stelic Institute Of Regenerative Medicine, Stelic Institute & Co., Niigata University filed Critical Stelic Institute Of Regenerative Medicine, Stelic Institute & Co.
Priority to EP20170385.7A priority patent/EP3711755A1/en
Publication of WO2009004995A1 publication Critical patent/WO2009004995A1/ja
Priority to US14/158,607 priority patent/US20140135379A1/en
Priority to US15/241,830 priority patent/US20160355818A1/en
Priority to US16/269,359 priority patent/US10689650B2/en
Priority to US16/869,812 priority patent/US11485974B2/en

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Cardiology (AREA)
  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
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Abstract

本発明は、標的とする粘膜下組織に生理活性物質を投与することにより、該組織特異的に生理活性物質を定着および発現させる方法を提供する。すなわち本発明者らは、粘膜下組織に対し、担体を利用せず直接生理活性物質を投与することによって、該生理活性物質が消失あるいは拡散したりせず、安全かつ効果的に長期間にわたって投与局所に定着し、さらにはリザーバーのように働き効果を発揮することを見出した。また上述のようにして投与された生理活性物質は投与臓器以外の他の臓器には影響を及ぼさず、治療効果を有することも見出した。
PCT/JP2008/061709 2007-06-29 2008-06-27 生理活性物質を定着および発現させる方法 WO2009004995A1 (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US12/666,983 US20100329993A1 (en) 2007-06-29 2008-06-27 Method of fixing and expressing physiologically active substance
EP21163980.2A EP3895737A1 (en) 2007-06-29 2008-06-27 Method of fixing and expressing physiologically active substance
EP08790674A EP2172226A4 (en) 2007-06-29 2008-06-27 METHOD FOR FIXING AND EXPRESSING A PHYSIOLOGICALLY ACTIVE SUBSTANCE
EP15201508.7A EP3034095B1 (en) 2007-06-29 2008-06-27 Method of fixing and expressing physiologically active substance
JP2009521604A JP5547964B2 (ja) 2007-06-29 2008-06-27 生理活性物質を定着および発現させる方法
EP18188952.8A EP3456357A1 (en) 2007-06-29 2008-06-27 Method of fixing and expressing physiologically active substance
EP20170385.7A EP3711755A1 (en) 2007-06-29 2008-06-27 Method of fixing and expressing physiologically active substance
US14/158,607 US20140135379A1 (en) 2007-06-29 2014-01-17 Method of fixing and expressing physiologically active substance
US15/241,830 US20160355818A1 (en) 2007-06-29 2016-08-19 Method of fixing and expressing physiologically active substance
US16/269,359 US10689650B2 (en) 2007-06-29 2019-02-06 Method of fixing and expressing physiologically active substance
US16/869,812 US11485974B2 (en) 2007-06-29 2020-05-08 Method of fixing and expressing physiologically active substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007171361 2007-06-29
JP2007-171361 2007-06-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/666,983 A-371-Of-International US20100329993A1 (en) 2007-06-29 2008-06-27 Method of fixing and expressing physiologically active substance
US14/158,607 Continuation US20140135379A1 (en) 2007-06-29 2014-01-17 Method of fixing and expressing physiologically active substance

Publications (1)

Publication Number Publication Date
WO2009004995A1 true WO2009004995A1 (ja) 2009-01-08

Family

ID=40226041

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Application Number Title Priority Date Filing Date
PCT/JP2008/061709 WO2009004995A1 (ja) 2007-06-29 2008-06-27 生理活性物質を定着および発現させる方法

Country Status (5)

Country Link
US (5) US20100329993A1 (ja)
EP (7) EP2638917A1 (ja)
JP (1) JP5547964B2 (ja)
ES (1) ES2685636T3 (ja)
WO (1) WO2009004995A1 (ja)

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WO2014013535A1 (ja) * 2012-07-17 2014-01-23 株式会社ステリック再生医科学研究所 粘膜治癒促進剤
JP2015515886A (ja) * 2012-05-01 2015-06-04 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 経皮挿入するための先端装填型マイクロニードルアレイ
WO2018105708A1 (ja) 2016-12-07 2018-06-14 株式会社ステリック再生医科学研究所 慢性疾患の治療及び予防用医薬組成物
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US10646579B2 (en) 2015-11-04 2020-05-12 Tme Therapeutics Inc. Complex comprising RNAi molecule and N-acetylated chitosan
EP3673910A1 (en) * 2007-12-27 2020-07-01 Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. Sugar chain-related gene and use thereof
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US11744927B2 (en) 2009-10-23 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin

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JPWO2009004995A1 (ja) 2010-08-26
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US11485974B2 (en) 2022-11-01
US20140135379A1 (en) 2014-05-15
EP2172226A4 (en) 2010-06-30
US20210040478A1 (en) 2021-02-11
EP3034095B1 (en) 2018-08-08
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