Classifications

• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
  • A23L33/105—Plant extracts, their artificial duplicates or their derivatives

Definitions

• the present invention relates to a novel health food comprising chlorella extract, a herbal extract obtained from a mixture of herbs selected from Panax ginseng, Ganoderma lucidum, Valeriana frauriei birq, Poria cocus, Zerumbet, Bupleurum scorzoneraefolium, Glycyrrhiza and along with a malt and honey.
• the novel health food has the enhancement effects of anti-oxidant, immunoenhancing, autonerve-modulating and hematopoiesis.
• Oxidative stress is a stress, caused by free radicals like superoxide occurred by metabolism, various diseases, radioactive rays and the like.
• Free radicals are natural by-products of daily metabolism and contribute to diseases and aging process.
• the presence of free radicals appears to contribute to suppression of the immune system and cells damage.
• the free radicals can suppress the immune cell, or macrophage, which plays essential and pivotal role in immune response.
• Antioxidants can counter the effects of free radicals, thereby enhancing immune function.
• lymphocytes are reduced in humans with immunosupression disorders or likely diseases, and the cytokines are also reduced accordingly. Cytokines play the important role in the immune system.
• the inhibition of the sympathetic nervous system may be used to enhance an immune response when the endogenous immune response is not sufficient, while sthenia of the parasympathetic nervous system may strengthen immune response.
• the immune defence function is enhanced by the immune stimulative, hematopoiesis accelarator and nutrition.
• the major object of the invention is to provide health food that enhances immune defense function to treat, or prevent various diseases.
• the immunomodulators, hematopoiesis-related agents and nutritional supplement enhance immune defences.
• the health food according to the present invention is prepared for the reduction of oxidation stress, activation of immunocyte, the control of autonomic nerve system and the enhance of hematopoiesis system.
• the health food according to the present invention comprises Chlorella extract, herbal extract obtained from a mixture of herbs selected from Panax ginseng, Ganoderma Lucidum, Valeriana fauriei briq, Poria cocus, Zerumbet, Bupleurum scorzoneraefolium, Glycyrrhiza and along with malt and honey.
• the chlorella called hyperaliment, is a single cell green algae, which contains polysaccharide, polysaccharide mixture and active glucan and is used as immune modulation agent.
• the chlorella is also rich in vitamins, mineral, esculent fiber, nucleic acids and amino acids.
• Panax ginseng enhances immune response by stimulating immune cells which secretes cytocine. It promotes fatigue and sanguification preventing hemolyzation. It also has effect on sthenia, exiting systema nervosum, cardiac, sexual stimulation, digestion and absortion, as well as anti-allergy. It also has antioxidative effect.
• Ganoderma lucidum contains ergosterol, protease, various amino acids, organic acids and polysacchrides. It is well kown for its effective treatment for the sedative action, spinal cord, prostate gland, autoimmunity diseases, hematopoiesis function, gastrointestinal tract, small bowel, colon and liver. The glucan and lentinan in ganoderma lucidum raise immune function and are used as antiblastic agent.
• polysccharides derived from chlorella, Panax ginseng, Ganoderma lucidum are known as immune cell-activating agent.
• This' invention is purposed to make the immune-stimulating activity of above-mentioned polysaccharide favorably toward the conditions of treatment for various disease.
• Valeriana frauriei birq has a good indication to improve the palpitation, nervousness, agrypnia and heart disorers, which is known to be so by the effect of its lipid component.
• Poria cocus contains large amount of pakaman belonging polysaccharide, which has aryypina and anetic action.
• Zerumbet contains Volatile oils and materials like oil, by which it is useful for the treatment of stomach ache, vomiting, vomiting of pregnancy, indigestion as the aromatic, stomachic and antemetic drug.
• Bupleurum scorzoneraefolium has antipyretic and sedative actions, by which it is useful for the of malaria, cold, intercostals neuralgia, nervous exhaustion, anxiety and soon and also the treatment of hepatitis, cholecystitis and cholepatia. It is known Such action
• Glycyrrhiza has been used for treatment of other diseases as ulcer and productive cough, and for the detoxification and flavor since long time ago and glycyrrhizin is known as main component of such indiciation.
• the various mineral and perula acids contained in malts are noted for its distinct antioxidant activity and sympathetic nerve-depressing activity.
• the present health food has shown wonderful treatment effect for diseases such as cerebrovascular disease, respiratory system disease, digestive systemdisease, urogenital system disease, metabolism disorders, hepatitis, tuberculosis, obstetrics and gynaecology diseases, autonomic neropathy and climacteric disorders.
• diseases such as cerebrovascular disease, respiratory system disease, digestive systemdisease, urogenital system disease, metabolism disorders, hepatitis, tuberculosis, obstetrics and gynaecology diseases, autonomic neropathy and climacteric disorders.
• the present invention provides a health food comprising of: Chlorella extract, herbal extract obtained from amixture of herbs selected from Panax ginseng, Ganoderma Lucidum, Valeriana fauriei briq, Poria cocus, Zerumbet, Bupleurum scorzoneraefolium, Glycyrrhiza and along with malt and honey.
• the content of chlorella extract is in the range about 5 mg to 50 mg, preferably 10 mg to 20 mg.
• Panax ginseng is in the range about 14% to 17% of the health food.
• Ganoderma Lucidum is in the range about 13% to 17% of the health food.
• Valeriana fauriei briq is in the range about 12% to 18% of the health food.
• Poria cocus is in the range about 10% to 15% of the health food.
• Zerumbet is in the range about 10% to 13% of the health food.
• Bupleurum scorzoneraefolium is in the range about 5% to 9% of the health food. In an embodiment of the present invention, Glycyrrhiza is in the range about 6% to 7% of the health food.
• the percentage ratio of the malt is in the range of 8 to 10.
• the health food provides antioxidant, autonerve-modulating, immune enhancing, and hematopoiesis properties.
• the present invention also provides a process for preparing the health food which has antioxidant, autonerve-modulating, immune-enhancing, and hematopoiesis properties.
• Example 1 Preparing of the composition according to the present Invention ,-,.;.
• Chloralla extract Dissolve the dried powder of chlorella in ethyl acetate, and extract at 45 0 C for 10 hr. Centrifuge (a)solution to obtain the supernant.
• compositions of the present invention and contents their compenents are shown tables 1, 2, 3 and.
• *mg is chlorella extract add, not w/w.
• DPPH of 5mg was dissolved in 100ml of 60% methanol to prepare a DPPH solution.
• Sample solution mixed solution of the DPPH solution (750/ ⁇ 1) and the UC(2O ⁇ £tl).
• Blank solution mixed solution of 60% methanol (750 ⁇ .1) and UC solution (200 ⁇ tI).
• Control solution mixed solution of the DPPH solution (750 ⁇ , 1) and 60% methanol(200/xl).
• Anti-oxidant activity (%) (C-S)/(C-B) X 100
• C Absorbance of the control
• B Absorbance of the blank
• S Absorbance of the sample
• Invention composition 1 2 3 4 anti-oxidant activity (%) 82 87 83 85
• the present invention compositions showed very high antioxidant activity.
• mice weighing 24-27g were exposed to 2Gy of 60Co, gamma, 0.3ml/kg of UC 2 was orally administered to mice for 30 days. 10 days, 20 days and 3Od ays after irradiation, irrespectively, the mice were killed to harvest the peripheral blood to measure the number of erythrocyte(red blood cell:RBC), leucocytes (white blood celkWBC) and blood ⁇ latelet(BP).
• RBC red blood cell
• leucocytes white blood celkWBC
• BP blood ⁇ latelet
• ECG II electrocardiogram II
• the ratios of LF/HF is reflected the function of sympathetic nerve system.
• UC 2 0.3ml/kg of the UC 2 were orally administrated to patients with insomnia, 2h after administration; LF/HF was measured according to above method.
• the present invention composition showed the effect on the invention of sympathetic nerve system and sthenia of the parasympathe tic nerve system.
• Example5 Effect of the invention composition on phagocytosis of cells from peripheral blood.
• mice A group of mice has been injected intraperitonealy with with PBS(control) or UC. 24 later, mice were scarified, peripheral blood from the orbital plexus was collected into heparine(5iv/ml).
• 0.1ml of heparinzed fresh blood was add to 0.05ml of diluted yeast particles(5*10 8 /ml) and incubated for 60 minutes at 37 0 C with occasional gentle agitation.
• the cell suspension was smeared over microscope slides.
• Cells with at least three engulfed particles were considered to be positive.
• Example 10 Effect of the invention composition on the engulfment of cells from peritoneal cavity
• mice A group of mice has been injected intrapritonealy with PBS(control) or UC. 24 later, mice were scarified, peritoneal cells were collected into medium. After counting the cells in hemocytometer, the peritoneal cells were dilated to l*10 7 cells in medium with 5% fetal calf serum.

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• Life Sciences & Earth Sciences (AREA)
• Botany (AREA)
• Mycology (AREA)
• Health & Medical Sciences (AREA)
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• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Food Science & Technology (AREA)
• Polymers & Plastics (AREA)
• Medicines Containing Plant Substances (AREA)
• Coloring Foods And Improving Nutritive Qualities (AREA)

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• 2008
  • 2008-01-21 WO PCT/KP2008/000012 patent/WO2008143365A1/en active Application Filing
  • 2008-01-21 CN CN2008800165844A patent/CN101686722B/zh not_active Expired - Fee Related

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