WO2008129730A1 - 経口投与剤の製造方法 - Google Patents

経口投与剤の製造方法 Download PDF

Info

Publication number
WO2008129730A1
WO2008129730A1 PCT/JP2007/074129 JP2007074129W WO2008129730A1 WO 2008129730 A1 WO2008129730 A1 WO 2008129730A1 JP 2007074129 W JP2007074129 W JP 2007074129W WO 2008129730 A1 WO2008129730 A1 WO 2008129730A1
Authority
WO
WIPO (PCT)
Prior art keywords
forming
water
swellable gel
layer
oral administration
Prior art date
Application number
PCT/JP2007/074129
Other languages
English (en)
French (fr)
Inventor
Akio Kabuto
Yusaku Sugiura
Eiji Suzuki
Hideaki Okabe
Original Assignee
Lintec Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lintec Corporation filed Critical Lintec Corporation
Priority to AU2007352009A priority Critical patent/AU2007352009B2/en
Priority to US12/593,896 priority patent/US8303741B2/en
Priority to CA002682300A priority patent/CA2682300A1/en
Priority to JP2009510739A priority patent/JP5199244B2/ja
Priority to CN200780053173.8A priority patent/CN101686898B/zh
Priority to EP07850633.4A priority patent/EP2133060A4/en
Publication of WO2008129730A1 publication Critical patent/WO2008129730A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1002—Methods of surface bonding and/or assembly therefor with permanent bending or reshaping or surface deformation of self sustaining lamina
    • Y10T156/1039—Surface deformation only of sandwich or lamina [e.g., embossed panels]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1002—Methods of surface bonding and/or assembly therefor with permanent bending or reshaping or surface deformation of self sustaining lamina
    • Y10T156/1043—Subsequent to assembly

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

　本発明は、第一の水膨潤性ゲル形成層及び第二の水膨潤性ゲル形成層が最外層に設けられ、第一と第二の水膨潤性ゲル形成層の周縁部どうしが直接又は接着剤層を介して接合されることにより形成された内包部に、薬物が封入されされた経口投与剤の製造方法、又は連続製造方法を提供する。この製造方法又は連続製造方法は、以下の工程を有する。（a）第一の水膨潤性ゲル形成層を形成する工程、（b）第一の水膨潤性ゲル形成層の所定部分に凹部を形成する工程、（c）形成した凹部内に薬物を充填する工程、及び、（d）充填された薬物の上に、直接又は接着剤層を介して、第二の水膨潤性ゲル形成層を形成し、凹部の周縁部を接合する工程。
PCT/JP2007/074129 2007-03-30 2007-12-14 経口投与剤の製造方法 WO2008129730A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2007352009A AU2007352009B2 (en) 2007-03-30 2007-12-14 Process for producing preparation for oral administration
US12/593,896 US8303741B2 (en) 2007-03-30 2007-12-14 Process for producing preparation for oral administration
CA002682300A CA2682300A1 (en) 2007-03-30 2007-12-14 Process for producing preparation for oral administration
JP2009510739A JP5199244B2 (ja) 2007-03-30 2007-12-14 経口投与剤の製造方法
CN200780053173.8A CN101686898B (zh) 2007-03-30 2007-12-14 口服给药制剂的制备方法
EP07850633.4A EP2133060A4 (en) 2007-03-30 2007-12-14 METHOD FOR PRODUCING PREPARATION FOR ORAL ADMINISTRATION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007092217 2007-03-30
JP2007-092217 2007-03-30

Publications (1)

Publication Number Publication Date
WO2008129730A1 true WO2008129730A1 (ja) 2008-10-30

Family

ID=39875268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/074129 WO2008129730A1 (ja) 2007-03-30 2007-12-14 経口投与剤の製造方法

Country Status (8)

Country Link
US (1) US8303741B2 (ja)
EP (1) EP2133060A4 (ja)
JP (1) JP5199244B2 (ja)
CN (1) CN101686898B (ja)
AU (1) AU2007352009B2 (ja)
CA (1) CA2682300A1 (ja)
TW (1) TWI394593B (ja)
WO (1) WO2008129730A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010035656A1 (ja) * 2008-09-29 2010-04-01 リンテック株式会社 経口投与剤
WO2010110320A1 (ja) * 2009-03-25 2010-09-30 リンテック株式会社 固形製剤
WO2010110322A1 (ja) * 2009-03-25 2010-09-30 リンテック株式会社 固形製剤
EP2263661A1 (en) * 2008-03-28 2010-12-22 LINTEC Corporation Oral preparation
US20120082723A1 (en) * 2010-03-31 2012-04-05 Mochida Pharmaceutical Co., Ltd. Easily administrable solid preparation
US9603805B2 (en) 2011-09-30 2017-03-28 Mochida Pharmaceutical Co., Ltd. Easily dosable solid preparation
JPWO2018074261A1 (ja) * 2016-10-17 2019-08-22 第一三共株式会社 封入容器の製造方法及び製造装置

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2700480A1 (en) * 2007-09-28 2009-04-02 Lintec Corporation Orally-administered agent
US20110111108A1 (en) * 2008-02-06 2011-05-12 University Of East Anglia Compositions and method for assisting swallowing
CN102711661A (zh) * 2010-01-29 2012-10-03 高露洁-棕榄公司 用于口腔治疗给药的牙条
CN101912613B (zh) * 2010-07-22 2012-01-04 杭州中美华东制药有限公司 掩味制剂
US8632839B2 (en) * 2010-10-19 2014-01-21 Covidien Lp Methods of forming self-supporting films for delivery of therapeutic agents
GB2533669B (en) * 2014-12-23 2016-12-14 Innovate Pharmaceuticals Ltd Salicylate compound composition
DE102017127452A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag Wasserlösliche Polymerklebschichten

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57114407A (en) * 1980-12-27 1982-07-16 Denpei Sakurai Method of packing pt packing
JPS61161215A (ja) * 1985-01-08 1986-07-21 Showa Denko Kk 固形物の易嚥下化処理法
JP2000516222A (ja) * 1996-08-15 2000-12-05 ロザン ファルマ ゲゼルシャフトミットベシュレンクテル ハフツング 嚥下が容易な経口医薬組成物
WO2002087622A1 (fr) 2001-04-24 2002-11-07 Lintec Corporation Preparations orales et supports pour preparations orales
WO2005063217A1 (en) * 2003-12-19 2005-07-14 Pediamed Pharmaceuticals, Inc. Oral medicament delivery system comprising collagen-based fibrous matrix
WO2005074882A2 (de) 2004-02-03 2005-08-18 Schering Ag Flächiges system zur anwendung in der mundhöhle
JP2005289868A (ja) 2004-03-31 2005-10-20 Lintec Corp 経口投与剤
JP2005298471A (ja) 2004-03-17 2005-10-27 Lintec Corp 薬剤の製造方法
JP2007044547A (ja) * 2006-10-12 2007-02-22 Toray Eng Co Ltd マイクロカプセルシート

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8702411D0 (en) * 1987-02-03 1987-03-11 Zyma Sa Swellable pellets
MX2007009430A (es) * 2005-02-03 2007-08-17 Cinv Ag Materiales para suministro de farmacos producidos mediante la tecnologia de sol/gel.

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57114407A (en) * 1980-12-27 1982-07-16 Denpei Sakurai Method of packing pt packing
JPS61161215A (ja) * 1985-01-08 1986-07-21 Showa Denko Kk 固形物の易嚥下化処理法
JP2000516222A (ja) * 1996-08-15 2000-12-05 ロザン ファルマ ゲゼルシャフトミットベシュレンクテル ハフツング 嚥下が容易な経口医薬組成物
WO2002087622A1 (fr) 2001-04-24 2002-11-07 Lintec Corporation Preparations orales et supports pour preparations orales
WO2005063217A1 (en) * 2003-12-19 2005-07-14 Pediamed Pharmaceuticals, Inc. Oral medicament delivery system comprising collagen-based fibrous matrix
WO2005074882A2 (de) 2004-02-03 2005-08-18 Schering Ag Flächiges system zur anwendung in der mundhöhle
JP2005298471A (ja) 2004-03-17 2005-10-27 Lintec Corp 薬剤の製造方法
JP2005289868A (ja) 2004-03-31 2005-10-20 Lintec Corp 経口投与剤
JP2007044547A (ja) * 2006-10-12 2007-02-22 Toray Eng Co Ltd マイクロカプセルシート

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2133060A4

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5453245B2 (ja) * 2008-03-28 2014-03-26 リンテック株式会社 経口投与剤
EP2263661A1 (en) * 2008-03-28 2010-12-22 LINTEC Corporation Oral preparation
EP2263661A4 (en) * 2008-03-28 2011-07-06 Lintec Corp ORAL PREPARATION
AU2009230345B2 (en) * 2008-03-28 2013-01-10 Lintec Corporation Oral preparation
EP2343059A1 (en) * 2008-09-29 2011-07-13 LINTEC Corporation Oral preparation
JPWO2010035656A1 (ja) * 2008-09-29 2012-02-23 リンテック株式会社 経口投与剤
WO2010035656A1 (ja) * 2008-09-29 2010-04-01 リンテック株式会社 経口投与剤
EP2343059A4 (en) * 2008-09-29 2013-01-16 Lintec Corp ORAL PREPARATION
WO2010110320A1 (ja) * 2009-03-25 2010-09-30 リンテック株式会社 固形製剤
WO2010110322A1 (ja) * 2009-03-25 2010-09-30 リンテック株式会社 固形製剤
CN102361634A (zh) * 2009-03-25 2012-02-22 琳得科株式会社 固体制剂
US20120082723A1 (en) * 2010-03-31 2012-04-05 Mochida Pharmaceutical Co., Ltd. Easily administrable solid preparation
US9603805B2 (en) 2011-09-30 2017-03-28 Mochida Pharmaceutical Co., Ltd. Easily dosable solid preparation
US9789068B2 (en) 2011-09-30 2017-10-17 Mochida Pharmaceutical Co., Ltd. Easily dosable solid preparation
JPWO2018074261A1 (ja) * 2016-10-17 2019-08-22 第一三共株式会社 封入容器の製造方法及び製造装置
JP2022164697A (ja) * 2016-10-17 2022-10-27 第一三共株式会社 封入容器の製造方法及び製造装置

Also Published As

Publication number Publication date
US20100126650A1 (en) 2010-05-27
TW200838568A (en) 2008-10-01
TWI394593B (zh) 2013-05-01
AU2007352009B2 (en) 2013-08-01
EP2133060A4 (en) 2013-04-10
JPWO2008129730A1 (ja) 2010-07-22
JP5199244B2 (ja) 2013-05-15
CA2682300A1 (en) 2008-10-30
CN101686898A (zh) 2010-03-31
CN101686898B (zh) 2013-05-29
US8303741B2 (en) 2012-11-06
AU2007352009A1 (en) 2008-10-30
EP2133060A1 (en) 2009-12-16

Similar Documents

Publication Publication Date Title
WO2008129730A1 (ja) 経口投与剤の製造方法
WO2006023444A3 (en) Anti-adhesion barrier
TW200600117A (en) Preparation for oral administration
WO2009010876A3 (en) Oral pouch product having soft edge and method of making
WO2009023672A3 (en) Abuse resistant drugs, method of use and method of making
WO2008046581A3 (de) Substituierte tetrahydropyrrolopyrazin-verbindungen als inhibitoren der monoaminwiederaufnahme und deren verwendung in arzeimitteln
MX339414B (es) Composicion farmaceutica que presenta propiedades anti-inflamatorias.
EP1752127A4 (en) METHOD FOR MANUFACTURING PREPARATION FOR ORAL ADMINISTRATION OF LAMINATED FILM CONTAINING AGGREGATED SUBSTANCE, AND PREPARATION FOR ORAL ADMINISTRATION OF LAMINATED FILM CONTAINING AGGREGATED SUBSTANCE
WO2009010875A3 (en) Oral delivery pouch product with coated seam
EP1740156B8 (de) Verfahren zur herstellung einer gegen missbrauch gesicherten, festen darreinchungsform
AU2003281711A1 (en) Substrate with parallax barrier layer, method for producing substrate with parallax barrier layer, and three-dimensional display
MX2013009416A (es) Conector para la preparacion de bebidas que comprende una lamina perforable mejorada y metodo para preparar una bebida.
WO2008085765A3 (en) Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
WO2010015419A3 (de) Wirkstoffhaltige fasernflächengebilde auf basis von biopolymeren, ihre anwendungen und verfahren zu ihrer herstellung
IL184152A (en) Monoclonal antibodies against nkg2a, preparations containing them, their use in drug preparation, methods of manufacture, and methods used in
WO2004093883A3 (en) Sachet for a pharmaceutical composition
IL197449A0 (en) Packaging for active substance-containing films and method for producing them
EP2324803A3 (en) Adhesive laminates and applications thereof
MY140142A (en) Method for manufacture of a multi-layer pipe
WO2006112717A3 (en) Nutritional supplement for a category of hiv patients
WO2006138735A3 (en) Gel compositions for topical administration
WO2006029845A3 (en) Delivery vehicle containing nanoparticles
WO2009092794A3 (fr) Objet muni d'un element graphique reporte sur un support et procede de realisation d'un tel objet
WO2007144169A3 (en) Entacapone-derivatives
WO2007132296A3 (en) Multilayer tablet

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780053173.8

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07850633

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2009510739

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2007850633

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2007352009

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2682300

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2007352009

Country of ref document: AU

Date of ref document: 20071214

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12593896

Country of ref document: US