WO2008111532A1 - インフルエンザワクチン含有凍結乾燥製剤、及びその製造方法 - Google Patents

インフルエンザワクチン含有凍結乾燥製剤、及びその製造方法 Download PDF

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Publication number
WO2008111532A1
WO2008111532A1 PCT/JP2008/054210 JP2008054210W WO2008111532A1 WO 2008111532 A1 WO2008111532 A1 WO 2008111532A1 JP 2008054210 W JP2008054210 W JP 2008054210W WO 2008111532 A1 WO2008111532 A1 WO 2008111532A1
Authority
WO
WIPO (PCT)
Prior art keywords
influenza vaccine
preparation
aqueous solution
lyophilized preparation
iii
Prior art date
Application number
PCT/JP2008/054210
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English (en)
French (fr)
Inventor
Chikamasa Yamashita
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP08721627A priority Critical patent/EP2119451A4/en
Priority to UAA200910179A priority patent/UA97391C2/ru
Priority to US12/529,893 priority patent/US8216588B2/en
Priority to CA2680193A priority patent/CA2680193C/en
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Priority to JP2009504039A priority patent/JP5388842B2/ja
Priority to MX2009009635A priority patent/MX2009009635A/es
Priority to BRPI0808037-2A2A priority patent/BRPI0808037A2/pt
Priority to RU2009137380/15A priority patent/RU2484847C2/ru
Priority to NZ579395A priority patent/NZ579395A/en
Priority to CN2008800077114A priority patent/CN101631563B/zh
Priority to AU2008225501A priority patent/AU2008225501B2/en
Publication of WO2008111532A1 publication Critical patent/WO2008111532A1/ja
Priority to IL200588A priority patent/IL200588A0/en
Priority to ZA2009/05952A priority patent/ZA200905952B/en
Priority to HK10105830.1A priority patent/HK1139076A1/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16051—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　本発明の目的は、インフルエンザワクチンの安定性が改善されている凍結乾燥製剤を提供することである。 　以下の(A)～(C)の条件を充足する水溶液を凍結乾燥させることにより、インフルエンザワクチンの安定性が顕著に改善された凍結乾燥製剤を得る：(A)(i)インフルエンザワクチン、(ii)疎水性アミノ酸、及び(iii)アルギニン及びその酸付加塩を含む、(B)前記(iii)成分が、得られる凍結乾燥製剤の総量に対して２０～８５重量％となるように配合されている、及び(c)前記(iii)成分を構成するアルギニンとその酸付加塩の比率をコントロールすることによって、ｐＨ８～１０に調整されている。
PCT/JP2008/054210 2007-03-09 2008-03-07 インフルエンザワクチン含有凍結乾燥製剤、及びその製造方法 WO2008111532A1 (ja)

Priority Applications (14)

Application Number Priority Date Filing Date Title
MX2009009635A MX2009009635A (es) 2007-03-09 2008-03-07 Preparacion liofilizada que comprende una vacuna para influenza y metodo para preparacion de la misma.
US12/529,893 US8216588B2 (en) 2007-03-09 2008-03-07 Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
CA2680193A CA2680193C (en) 2007-03-09 2008-03-07 Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
RU2009137380/15A RU2484847C2 (ru) 2007-03-09 2008-03-07 Лиофилизированный препарат, содержащий гриппозную вакцину, и способ его получения
JP2009504039A JP5388842B2 (ja) 2007-03-09 2008-03-07 インフルエンザワクチン含有凍結乾燥製剤、及びその製造方法
UAA200910179A UA97391C2 (ru) 2007-03-09 2008-03-07 Лиофилизированный препарат, содержащий гриппозную вакцину, и способ его получения
BRPI0808037-2A2A BRPI0808037A2 (pt) 2007-03-09 2008-03-07 Preparação liofilizada contendo vacina contra gripe e método para preparação da mesma.
EP08721627A EP2119451A4 (en) 2007-03-09 2008-03-07 LYOPHILIZED PREPARATION COMPRISING THE INFLUENZA VACCINE AND PREPARATION METHOD THEREOF
NZ579395A NZ579395A (en) 2007-03-09 2008-03-07 Influenza vaccine with improved presevation and stability properties comprising a hydrophobic amino acid, arginine and an acid addition salt
CN2008800077114A CN101631563B (zh) 2007-03-09 2008-03-07 含有流感疫苗的冻干制剂及其制备方法
AU2008225501A AU2008225501B2 (en) 2007-03-09 2008-03-07 Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
IL200588A IL200588A0 (en) 2007-03-09 2009-08-26 Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
ZA2009/05952A ZA200905952B (en) 2007-03-09 2009-08-27 Lyophilized preparation comprising influenza vaccine,and method for preparation thereof
HK10105830.1A HK1139076A1 (en) 2007-03-09 2010-06-10 Lyophilized preparation comprising influenza vaccine, and method for preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007059724 2007-03-09
JP2007-059724 2007-03-09

Publications (1)

Publication Number Publication Date
WO2008111532A1 true WO2008111532A1 (ja) 2008-09-18

Family

ID=39759470

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054210 WO2008111532A1 (ja) 2007-03-09 2008-03-07 インフルエンザワクチン含有凍結乾燥製剤、及びその製造方法

Country Status (20)

Country Link
US (1) US8216588B2 (ja)
EP (1) EP2119451A4 (ja)
JP (1) JP5388842B2 (ja)
KR (1) KR20090128463A (ja)
CN (1) CN101631563B (ja)
AR (1) AR065640A1 (ja)
AU (1) AU2008225501B2 (ja)
BR (1) BRPI0808037A2 (ja)
CA (1) CA2680193C (ja)
HK (1) HK1139076A1 (ja)
IL (1) IL200588A0 (ja)
MX (1) MX2009009635A (ja)
MY (1) MY149924A (ja)
NZ (1) NZ579395A (ja)
RU (1) RU2484847C2 (ja)
SG (1) SG179406A1 (ja)
TW (1) TWI428140B (ja)
UA (1) UA97391C2 (ja)
WO (1) WO2008111532A1 (ja)
ZA (1) ZA200905952B (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014523243A (ja) * 2011-06-28 2014-09-11 ロイコケア・アクチェンゲゼルシャフト ウイルスまたは細菌の新規な安定化方法
WO2017090767A1 (ja) * 2015-11-27 2017-06-01 日東電工株式会社 インフルエンザワクチン乾燥製剤、及び、インフルエンザワクチン乾燥製剤の製造方法
US10195242B2 (en) * 2013-01-25 2019-02-05 Wintermute Biomedical, Inc. Therapeutic compounds
JP2019163271A (ja) * 2013-09-03 2019-09-26 ジョージア テック リサーチ コーポレイション 熱安定性ワクチン製剤及びマイクロニードル
US11065220B2 (en) 2017-02-13 2021-07-20 Wintermute Biomedical, Inc. Anti-pathogenic therapeutic compositions
US11103475B2 (en) 2018-10-01 2021-08-31 Wintermute Biomedical, Inc. Therapeutic compositions of undecylenic acid and arginine

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0614460D0 (en) * 2006-07-20 2006-08-30 Novartis Ag Vaccines
GB201314248D0 (en) * 2013-08-08 2013-09-25 Glaxosmithkline Biolog Sa Saccharide vaccine formulation
JP2016534070A (ja) * 2013-10-25 2016-11-04 ロイコケア・アクチェンゲゼルシャフト 安定化ワクチンの製造のための新規方法
WO2017090769A1 (ja) 2015-11-27 2017-06-01 日東電工株式会社 インフルエンザワクチン乾燥製剤、及び、インフルエンザワクチン乾燥製剤の製造方法
WO2017090766A1 (ja) 2015-11-27 2017-06-01 日東電工株式会社 口腔内投与用ワクチン医薬組成物及び口腔内投与用ワクチン医薬組成物の製造方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183628A (ja) * 1982-04-06 1983-10-26 アメリカン・サイアナミド・カンパニ− インフルエンザウイルスワクチンの安定化
JPH05320071A (ja) * 1992-05-22 1993-12-03 Biseibutsu Kagaku Kenkyusho:Kk 牛伝染性鼻気管炎ウイルス感染症、牛ウイルス性下痢−粘膜病ウイルス感染症、パラインフルエンザ３型ウイルス感染症、牛ｒｓウイルス感染症および牛アデノ７型ウイルス感染症５種混合生ワクチン
JPH0665096A (ja) * 1981-05-13 1994-03-08 Inst Pasteur 安定化されたワクチン及びその製造法
WO2001074397A1 (fr) * 2000-03-31 2001-10-11 Kirin Beer Kabushiki Kaisha Preparation en poudre destinee a etre administree par les muqueuses comprenant un medicament de forme polymere et presentant une stabilite de conservation amelioree
WO2006041819A1 (en) * 2004-10-06 2006-04-20 Medimmune Vaccines, Inc. Refrigerator-temperature stable influenza vaccine compositions
JP2006519028A (ja) * 2003-02-25 2006-08-24 メッドイミューン バクシーンズ、インコーポレイティド インフルエンザワクチン組成物を生成する方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07121871B2 (ja) * 1986-10-09 1995-12-25 国立予防衛生研究所長 インフルエンザワクチン凍結乾燥製剤
JPH05229960A (ja) * 1990-10-30 1993-09-07 Dai Ichi Seiyaku Co Ltd 新規インフルエンザワクチン
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
JP2004054555A (ja) * 2002-07-19 2004-02-19 Yokogawa Electric Corp 表示装置
RU2290205C1 (ru) * 2005-09-13 2006-12-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунологическим препаратам "МИКРОГЕН" Министерства здравоохранения Российской Федерации Способ получения живой вакцины для профилактики гриппа

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665096A (ja) * 1981-05-13 1994-03-08 Inst Pasteur 安定化されたワクチン及びその製造法
JPS58183628A (ja) * 1982-04-06 1983-10-26 アメリカン・サイアナミド・カンパニ− インフルエンザウイルスワクチンの安定化
JPH05320071A (ja) * 1992-05-22 1993-12-03 Biseibutsu Kagaku Kenkyusho:Kk 牛伝染性鼻気管炎ウイルス感染症、牛ウイルス性下痢−粘膜病ウイルス感染症、パラインフルエンザ３型ウイルス感染症、牛ｒｓウイルス感染症および牛アデノ７型ウイルス感染症５種混合生ワクチン
WO2001074397A1 (fr) * 2000-03-31 2001-10-11 Kirin Beer Kabushiki Kaisha Preparation en poudre destinee a etre administree par les muqueuses comprenant un medicament de forme polymere et presentant une stabilite de conservation amelioree
JP2006519028A (ja) * 2003-02-25 2006-08-24 メッドイミューン バクシーンズ、インコーポレイティド インフルエンザワクチン組成物を生成する方法
WO2006041819A1 (en) * 2004-10-06 2006-04-20 Medimmune Vaccines, Inc. Refrigerator-temperature stable influenza vaccine compositions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEBORAH A. BUONAGURIO ET AL., VACCINE, vol. 24, 2006, pages 2151 - 2160
ROBERT J. GARMISE ET AL., AAPS PHARMSCITECH, vol. 7, no. 1, 2006, pages E1 - E7
See also references of EP2119451A4
STEPHEN E. ZWEIG, VACCINE, vol. 24, 2006, pages 5977 - 5985

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014523243A (ja) * 2011-06-28 2014-09-11 ロイコケア・アクチェンゲゼルシャフト ウイルスまたは細菌の新規な安定化方法
JP2017123861A (ja) * 2011-06-28 2017-07-20 ロイコケア・アクチェンゲゼルシャフト ウイルスまたは細菌の新規な安定化方法
US10195242B2 (en) * 2013-01-25 2019-02-05 Wintermute Biomedical, Inc. Therapeutic compounds
JP2019163271A (ja) * 2013-09-03 2019-09-26 ジョージア テック リサーチ コーポレイション 熱安定性ワクチン製剤及びマイクロニードル
JP7358068B2 (ja) 2013-09-03 2023-10-10 ジョージア テック リサーチ コーポレイション 熱安定性ワクチン製剤及びマイクロニードル
WO2017090767A1 (ja) * 2015-11-27 2017-06-01 日東電工株式会社 インフルエンザワクチン乾燥製剤、及び、インフルエンザワクチン乾燥製剤の製造方法
US11065220B2 (en) 2017-02-13 2021-07-20 Wintermute Biomedical, Inc. Anti-pathogenic therapeutic compositions
US11103475B2 (en) 2018-10-01 2021-08-31 Wintermute Biomedical, Inc. Therapeutic compositions of undecylenic acid and arginine
US11154524B2 (en) 2018-10-01 2021-10-26 Wintermute Biomedical, Inc. Therapeutic compositions of decanoic acid and arginine

Also Published As

Publication number Publication date
EP2119451A4 (en) 2012-05-16
JPWO2008111532A1 (ja) 2010-06-24
CA2680193A1 (en) 2008-09-18
AU2008225501B2 (en) 2013-08-29
HK1139076A1 (en) 2010-09-10
US8216588B2 (en) 2012-07-10
EP2119451A1 (en) 2009-11-18
UA97391C2 (ru) 2012-02-10
MX2009009635A (es) 2009-09-22
BRPI0808037A2 (pt) 2014-06-17
MY149924A (en) 2013-10-31
CA2680193C (en) 2015-05-05
KR20090128463A (ko) 2009-12-15
NZ579395A (en) 2012-05-25
IL200588A0 (en) 2010-05-17
RU2009137380A (ru) 2011-04-20
TW200848074A (en) 2008-12-16
AR065640A1 (es) 2009-06-17
AU2008225501A2 (en) 2009-09-24
RU2484847C2 (ru) 2013-06-20
CN101631563A (zh) 2010-01-20
US20100104595A1 (en) 2010-04-29
TWI428140B (zh) 2014-03-01
ZA200905952B (en) 2010-11-24
JP5388842B2 (ja) 2014-01-15
SG179406A1 (en) 2012-04-27
CN101631563B (zh) 2013-07-24
AU2008225501A1 (en) 2008-09-18

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