WO2008111485A1 - モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物、核酸、標識物質、核酸検出方法およびキット - Google Patents

モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物、核酸、標識物質、核酸検出方法およびキット Download PDF

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Publication number
WO2008111485A1
WO2008111485A1 PCT/JP2008/054054 JP2008054054W WO2008111485A1 WO 2008111485 A1 WO2008111485 A1 WO 2008111485A1 JP 2008054054 W JP2008054054 W JP 2008054054W WO 2008111485 A1 WO2008111485 A1 WO 2008111485A1
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Prior art keywords
nucleic acid
compound
skeleton
mononucleoside
mononucleotide
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PCT/JP2008/054054
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English (en)
French (fr)
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Akimitsu Okamoto
Shuji Ikeda
Takeshi Kubota
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Riken
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Priority to US12/530,574 priority Critical patent/US8383792B2/en
Priority to EP08721474A priority patent/EP2130835B1/en
Priority to ES08721474T priority patent/ES2385268T3/es
Priority to JP2009504009A priority patent/JP4761086B2/ja
Priority to CN2008800076357A priority patent/CN101631796B/zh
Publication of WO2008111485A1 publication Critical patent/WO2008111485A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　例えば、核酸の二重らせん構造を効果的に検出可能な標識物質を提供する。 　モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物であって、前記構造が下記式（１）、（１ｂ）または（１ｃ）で表される化合物、その互変異性体若しくは立体異性体、またはそれらの塩を提供する。 　例えば、Ｂは、核酸塩基骨格を有する原子団であり、Ｅは、デオキシリボース骨格、リボース骨格、もしくはそれらのいずれかから誘導される構造を有する原子団、またはペプチド構造もしくはペプトイド構造を有する原子団であり、Ｚ１１およびＺ１２は、それぞれ、水素原子、保護基、または蛍光性を示す原子団であり、同一でも異なっていてもよい。  
PCT/JP2008/054054 2007-03-09 2008-03-06 モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物、核酸、標識物質、核酸検出方法およびキット WO2008111485A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/530,574 US8383792B2 (en) 2007-03-09 2008-03-06 Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid
EP08721474A EP2130835B1 (en) 2007-03-09 2008-03-06 Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid
ES08721474T ES2385268T3 (es) 2007-03-09 2008-03-06 Compuesto que tiene una estructura derivada de mononucleósido o mononucleótido, ácido nucleico, sustancia marcadora y método y kit para la detección de ácido nucleico
JP2009504009A JP4761086B2 (ja) 2007-03-09 2008-03-06 核酸、標識物質、核酸検出方法およびキット
CN2008800076357A CN101631796B (zh) 2007-03-09 2008-03-06 具有由单核苷或单核苷酸衍生的结构的化合物、核酸、标记物以及核酸检测方法和试剂盒

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007059921 2007-03-09
JP2007-059921 2007-03-09
JP2007-246253 2007-09-21
JP2007246253 2007-09-21
JP2007-335352 2007-12-26
JP2007335352 2007-12-26

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WO2008111485A1 true WO2008111485A1 (ja) 2008-09-18

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Country Status (6)

Country Link
US (1) US8383792B2 (ja)
EP (1) EP2130835B1 (ja)
JP (2) JP4761086B2 (ja)
KR (1) KR101551985B1 (ja)
ES (1) ES2385268T3 (ja)
WO (1) WO2008111485A1 (ja)

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WO2012091091A1 (ja) 2010-12-28 2012-07-05 独立行政法人理化学研究所 化合物、核酸、核酸の製造方法および核酸を製造するためのキット
WO2014034818A1 (ja) * 2012-08-30 2014-03-06 株式会社ダナフォーム 標的核酸の分析方法、キットおよび分析機器
WO2014038561A1 (ja) * 2012-09-04 2014-03-13 株式会社ダナフォーム 化合物、核酸、標識物質および検出方法
JP5618436B2 (ja) * 2012-07-16 2014-11-05 株式会社ダナフォーム 核酸プローブ、核酸プローブの設計方法、およびターゲット配列の検出方法
WO2015152024A1 (ja) * 2014-03-31 2015-10-08 独立行政法人理化学研究所 蛍光性標識一本鎖核酸及びその用途

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RU2452944C1 (ru) * 2010-10-05 2012-06-10 Государственное образовательное учреждение высшего профессионального образования "Самарский государственный университет" Способ оценки подлинности лекарственного растительного сырья и устройство для его осуществления
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JP2014530208A (ja) * 2011-09-28 2014-11-17 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト アゾメディエーター
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JP6923517B2 (ja) 2015-10-09 2021-08-18 ユニバーシティ・オブ・サザンプトン 遺伝子発現の調節及び脱制御されたタンパク質発現のスクリーニング
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US20190160466A1 (en) 2016-08-03 2019-05-30 Kabushiki Kaisha Dnaform Analysis cell, analysis device, analysis apparatus, and analysis system
JP6448695B2 (ja) 2017-03-21 2019-01-09 株式会社東芝 Ｒｎａ増幅方法、ｒｎａ検出方法及びアッセイキット
AU2018300069A1 (en) 2017-07-11 2020-02-27 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
JP7055691B2 (ja) 2017-07-11 2022-04-18 株式会社東芝 短鎖核酸伸長用プライマーセット、アッセイキット、短鎖核酸伸長方法、増幅方法及び検出方法
WO2019028425A1 (en) 2017-08-03 2019-02-07 Synthorx, Inc. CONJUGATES OF CYTOKINE FOR THE TREATMENT OF AUTOIMMUNE DISEASES
SG11202001590RA (en) 2017-08-25 2020-03-30 Stoke Therapeutics Inc Antisense oligomers for treatment of conditions and diseases
KR102627534B1 (ko) * 2018-06-21 2024-01-19 에프. 호프만-라 로슈 아게 전부-lna 올리고뉴클레오티드 혼성화
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WO2010061922A1 (ja) 2008-11-27 2010-06-03 独立行政法人理化学研究所 新規ＭｕｔＳタンパク質およびそれを用いた変異の判定方法
WO2012091091A1 (ja) 2010-12-28 2012-07-05 独立行政法人理化学研究所 化合物、核酸、核酸の製造方法および核酸を製造するためのキット
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JP5618436B2 (ja) * 2012-07-16 2014-11-05 株式会社ダナフォーム 核酸プローブ、核酸プローブの設計方法、およびターゲット配列の検出方法
JPWO2014013954A1 (ja) * 2012-07-16 2016-06-30 株式会社ダナフォーム 核酸プローブ、核酸プローブの設計方法、およびターゲット配列の検出方法
US9862989B2 (en) 2012-07-16 2018-01-09 Kabushiki Kaisha Dnaform Nucleic acid probe, method for designing nucleic acid probe, and method for detecting target sequence
WO2014034818A1 (ja) * 2012-08-30 2014-03-06 株式会社ダナフォーム 標的核酸の分析方法、キットおよび分析機器
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JP5598784B2 (ja) * 2012-08-30 2014-10-01 株式会社ダナフォーム 標的核酸の分析方法、キットおよび分析機器
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JPWO2014038561A1 (ja) * 2012-09-04 2016-08-12 株式会社ダナフォーム 化合物、核酸、標識物質および検出方法
WO2014038561A1 (ja) * 2012-09-04 2014-03-13 株式会社ダナフォーム 化合物、核酸、標識物質および検出方法
US10294261B2 (en) 2012-09-04 2019-05-21 Kabushiki Kaisha Dnaform Compound, nucleic acid, labeling substance, and detection method
EA034342B1 (ru) * 2012-09-04 2020-01-29 КАБУСИКИ КАЙСЯ ДиЭнЭйФОРМ Соединение, нуклеиновая кислота, вещество, несущее метку, и способ обнаружения
JPWO2015152024A1 (ja) * 2014-03-31 2017-04-13 国立研究開発法人理化学研究所 蛍光性標識一本鎖核酸及びその用途
WO2015152024A1 (ja) * 2014-03-31 2015-10-08 独立行政法人理化学研究所 蛍光性標識一本鎖核酸及びその用途
US10428371B2 (en) 2014-03-31 2019-10-01 Kabushiki Kaisha Dnaform Fluorescent labeled single-stranded nucleic acid and use thereof
EA037029B1 (ru) * 2014-03-31 2021-01-28 КАБУСИКИ КАЙСЯ ДиЭнЭйФОРМ Флуоресцентно меченная одноцепочечная нуклеиновая кислота и ее применение

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US8383792B2 (en) 2013-02-26
JP4761086B2 (ja) 2011-08-31
EP2130835A1 (en) 2009-12-09
EP2130835B1 (en) 2012-05-23
JP2011173891A (ja) 2011-09-08
KR101551985B1 (ko) 2015-09-09
ES2385268T3 (es) 2012-07-20
EP2130835A4 (en) 2010-06-16
JPWO2008111485A1 (ja) 2010-06-24
US20100092971A1 (en) 2010-04-15
KR20090117814A (ko) 2009-11-12

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