WO2008156139A1 - 同位体化合物を標識として使用するタンパク質の分析方法 - Google Patents
同位体化合物を標識として使用するタンパク質の分析方法 Download PDFInfo
- Publication number
- WO2008156139A1 WO2008156139A1 PCT/JP2008/061243 JP2008061243W WO2008156139A1 WO 2008156139 A1 WO2008156139 A1 WO 2008156139A1 JP 2008061243 W JP2008061243 W JP 2008061243W WO 2008156139 A1 WO2008156139 A1 WO 2008156139A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- analysis method
- label
- protein analysis
- isotope compound
- protein
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009520532A JP4883540B2 (ja) | 2007-06-21 | 2008-06-19 | 同位体化合物を標識として使用するタンパク質の分析方法 |
US12/452,233 US8071392B2 (en) | 2007-06-21 | 2008-06-19 | Mass spectrometric analysis of proteins using stable isotopes of pyrylium derivates as labels |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007164249 | 2007-06-21 | ||
JP2007-164249 | 2007-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008156139A1 true WO2008156139A1 (ja) | 2008-12-24 |
Family
ID=40156297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/061243 WO2008156139A1 (ja) | 2007-06-21 | 2008-06-19 | 同位体化合物を標識として使用するタンパク質の分析方法 |
Country Status (3)
Country | Link |
---|---|
US (1) | US8071392B2 (ja) |
JP (1) | JP4883540B2 (ja) |
WO (1) | WO2008156139A1 (ja) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012215556A (ja) * | 2011-03-31 | 2012-11-08 | Univ Of Fukui | アミノ基含有非ペプチド化合物を高効率かつ高感度で多重定量する方法およびそのためのキット |
WO2013147096A1 (ja) | 2012-03-30 | 2013-10-03 | 国立大学法人福井大学 | 同位体標識ピリリウム化合物 |
JP2014522496A (ja) * | 2011-06-06 | 2014-09-04 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 試料中の標的分析物を定量化するための組成物、方法およびキット |
JP2015068762A (ja) * | 2013-09-30 | 2015-04-13 | 大陽日酸株式会社 | タンパク質又はペプチドの解析方法、及び、ピリリウム化ペプチド精製濃縮キット |
JP2015518167A (ja) * | 2012-05-29 | 2015-06-25 | バイオデシックス・インコーポレイテッドBiodesix Inc | 複合的生物試料(例えば、血清)のディープ−malditof質量分析方法およびその使用 |
JP2018077250A (ja) * | 2009-12-11 | 2018-05-17 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 複合試料中のステロイド化合物の質量分析 |
US10267810B2 (en) | 2005-04-06 | 2019-04-23 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
US10429398B2 (en) | 2009-12-03 | 2019-10-01 | Quest Diagnostics Investments Incorporated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
US10753950B2 (en) | 2009-12-11 | 2020-08-25 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin D |
CN112876532A (zh) * | 2019-11-29 | 2021-06-01 | 中国科学院大连化学物理研究所 | 一种基于光化学的蛋白质标记方法 |
US11650216B2 (en) | 2007-11-28 | 2023-05-16 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9027681B2 (en) | 2009-12-04 | 2015-05-12 | Massachusetts Institute Of Technology | Hybrid sensor-enabled electric wheel and associated systems, multi-hub wheel spoking systems, and methods of manufacturing and installing wheel spokes |
JP5427962B2 (ja) * | 2011-01-07 | 2014-02-26 | 株式会社日立ハイテクノロジーズ | 質量分析装置、分析法およびキャリブレーション試料 |
EP2798658B1 (en) * | 2011-12-30 | 2017-03-01 | DH Technologies Development Pte. Ltd. | Systems and methods for sequencing peptides by mass spectrometry |
WO2015154046A1 (en) | 2014-04-04 | 2015-10-08 | Superpedestrian, Inc. | Systems, methods, and devices for the operation of electrically motorized vehicles |
US10308065B2 (en) | 2014-04-04 | 2019-06-04 | Superpedestrian, Inc. | Devices and methods for connecting a spoke to a hub |
WO2016086057A1 (en) | 2014-11-24 | 2016-06-02 | Superpedestrian, Inc. | Devices and methods of a motorized wheel |
CN112630345B (zh) * | 2020-12-14 | 2022-09-30 | 中国计量科学研究院 | 检测氘标记化合物同位素分布与丰度的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003107066A (ja) * | 1998-08-25 | 2003-04-09 | Univ Of Washington | 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析 |
JP2005181011A (ja) * | 2003-12-17 | 2005-07-07 | Yoshio Yamauchi | タンパク質解析方法 |
JP2007127631A (ja) * | 2005-10-17 | 2007-05-24 | Centro De Ingenieria Genetica Y Biotechnologia | 定量的プロテオミクスに適用可能な多重荷電されたペプチドの選択的分離方法 |
-
2008
- 2008-06-19 WO PCT/JP2008/061243 patent/WO2008156139A1/ja active Application Filing
- 2008-06-19 US US12/452,233 patent/US8071392B2/en not_active Expired - Fee Related
- 2008-06-19 JP JP2009520532A patent/JP4883540B2/ja not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003107066A (ja) * | 1998-08-25 | 2003-04-09 | Univ Of Washington | 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析 |
JP2005181011A (ja) * | 2003-12-17 | 2005-07-07 | Yoshio Yamauchi | タンパク質解析方法 |
JP2007127631A (ja) * | 2005-10-17 | 2007-05-24 | Centro De Ingenieria Genetica Y Biotechnologia | 定量的プロテオミクスに適用可能な多重荷電されたペプチドの選択的分離方法 |
Non-Patent Citations (3)
Title |
---|
CRAIG D.B. ET AL.: "Determination of picomolar concentrations of proteins using novel amino reactive chameleon labels and capillary electrophoresis laser-induced fluorescence detection", ELECTROPHORESIS, vol. 26, no. 11, 9 May 2005 (2005-05-09), pages 2208 - 2213, XP002504553 * |
GOSHE M.B. ET AL.: "Stable isotope-coded proteomic mass spectrometry", CURRENT OPINION IN BIOTECHNOLOGY, vol. 14, no. 1, February 2003 (2003-02-01), pages 101 - 109, XP009020301 * |
ION GHIVIRGA ET AL.: "Rotation Barriers in Pyridinium Salts Depend on the Number of Available Ground State Conformations", CROATICA CHEMICA ACTA, vol. 77, no. 1-2, 2004, pages 391 - 396 * |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10267810B2 (en) | 2005-04-06 | 2019-04-23 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
US11921122B2 (en) | 2005-04-06 | 2024-03-05 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
US11579154B2 (en) | 2005-04-06 | 2023-02-14 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
US10935558B2 (en) | 2005-04-06 | 2021-03-02 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
US11650216B2 (en) | 2007-11-28 | 2023-05-16 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
US11885820B2 (en) | 2009-12-03 | 2024-01-30 | Quest Diagnostics Investments Incorporated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
US11105821B2 (en) | 2009-12-03 | 2021-08-31 | Quest Diagnostics Investments Incorporated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
US10429398B2 (en) | 2009-12-03 | 2019-10-01 | Quest Diagnostics Investments Incorporated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
US11280799B2 (en) | 2009-12-11 | 2022-03-22 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin D |
US11549954B2 (en) | 2009-12-11 | 2023-01-10 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin D |
US10753950B2 (en) | 2009-12-11 | 2020-08-25 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin D |
US11852636B2 (en) | 2009-12-11 | 2023-12-26 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin D |
US10955424B2 (en) | 2009-12-11 | 2021-03-23 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplexed patient samples |
US11808773B2 (en) | 2009-12-11 | 2023-11-07 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplexed patient samples |
JP2018077250A (ja) * | 2009-12-11 | 2018-05-17 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 複合試料中のステロイド化合物の質量分析 |
JP2012215556A (ja) * | 2011-03-31 | 2012-11-08 | Univ Of Fukui | アミノ基含有非ペプチド化合物を高効率かつ高感度で多重定量する方法およびそのためのキット |
US9768001B2 (en) | 2011-06-06 | 2017-09-19 | Waters Technologies Corporation | Compositions, methods, and kits for quantifying target analytes in a sample |
US10304670B2 (en) | 2011-06-06 | 2019-05-28 | Waters Technologies Corporation | Compositions, methods, and kits for quantifying target analytes in a sample |
JP2014522496A (ja) * | 2011-06-06 | 2014-09-04 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 試料中の標的分析物を定量化するための組成物、方法およびキット |
JPWO2013147096A1 (ja) * | 2012-03-30 | 2015-12-14 | 国立大学法人福井大学 | 同位体標識ピリリウム化合物 |
US9347949B2 (en) | 2012-03-30 | 2016-05-24 | National University Corporation University Of Fukui | Isotope-labeled pyrylium compound |
WO2013147096A1 (ja) | 2012-03-30 | 2013-10-03 | 国立大学法人福井大学 | 同位体標識ピリリウム化合物 |
JP2015518167A (ja) * | 2012-05-29 | 2015-06-25 | バイオデシックス・インコーポレイテッドBiodesix Inc | 複合的生物試料(例えば、血清)のディープ−malditof質量分析方法およびその使用 |
US9606101B2 (en) | 2012-05-29 | 2017-03-28 | Biodesix, Inc. | Deep MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof |
JP2015068762A (ja) * | 2013-09-30 | 2015-04-13 | 大陽日酸株式会社 | タンパク質又はペプチドの解析方法、及び、ピリリウム化ペプチド精製濃縮キット |
CN112876532B (zh) * | 2019-11-29 | 2022-09-30 | 中国科学院大连化学物理研究所 | 一种基于光化学的蛋白质标记方法 |
CN112876532A (zh) * | 2019-11-29 | 2021-06-01 | 中国科学院大连化学物理研究所 | 一种基于光化学的蛋白质标记方法 |
Also Published As
Publication number | Publication date |
---|---|
US8071392B2 (en) | 2011-12-06 |
JP4883540B2 (ja) | 2012-02-22 |
JPWO2008156139A1 (ja) | 2010-08-26 |
US20100190261A1 (en) | 2010-07-29 |
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